Search

Your search keyword '"CLAVENZANI, PAOLO"' showing total 291 results
Start Over Author "CLAVENZANI, PAOLO"
291 results on '"CLAVENZANI, PAOLO"'

1. Distribution, quantification, and characterization of substance P enteric neurons in the submucosal and myenteric plexuses of the porcine colon.

Author

Mazzoni, Maurizio, Cabanillas, Luis, Costanzini, Anna, Caremoli, Filippo, Million, Mulugeta, Larauche, Muriel, Clavenzani, Paolo, De Giorgio, Roberto, and Sternini, Catia

Subjects
Cholinergic and nitrergic transmission, Excitatory motor neurons, Inhibitory motor neurons, Interneurons, Secretomotor neurons, Humans, Swine, Animals, Myenteric Plexus, Submucous Plexus, Substance P, Neurons, Colon, Choline O-Acetyltransferase
Abstract

The pig is an important translational model for studying intestinal physiology and disorders for its many homologies with humans, including the organization of the enteric nervous system (ENS), the major regulator of gastrointestinal functions. This study focused on the quantification and neurochemical characterization of substance P (SP) neurons in the pig ascending (AC) and descending colon (DC) in wholemount preparations of the inner submucosal plexus (ISP), outer submucosal plexus (OSP), and myenteric plexus (MP). We used antibodies for the pan-neuronal marker HuCD, and choline acetyltransferase (ChAT) and neuronal nitric oxide synthase (nNOS), markers for excitatory and inhibitory transmitters, for multiple labeling immunofluorescence and high-resolution confocal microscopy. The highest density of SP immunoreactive (IR) neurons was in the ISP (222/mm2 in the AC, 166/mm2 in the DC), where they make up about a third of HuCD-IR neurons, compared to the OSP and MP (19-22% and 13-17%, respectively, P

Published
2024

4. Quantitative analysis of enteric neurons containing choline acetyltransferase and nitric oxide synthase immunoreactivities in the submucosal and myenteric plexuses of the porcine colon

Author

Mazzoni, Maurizio, Caremoli, Filippo, Cabanillas, Luis, de los Santos, Janira, Million, Mulugeta, Larauche, Muriel, Clavenzani, Paolo, De Giorgio, Roberto, and Sternini, Catia

Subjects
Biomedical and Clinical Sciences, Neurosciences, Digestive Diseases, Animals, Cell Count, Choline O-Acetyltransferase, Colon, Enteric Nervous System, Male, Myenteric Plexus, Neurons, Nitric Oxide Synthase, Submucous Plexus, Swine, Swine, Miniature, Enteric nervous system, Excitatory motor neurons, Inhibitory motor neurons, Secretomotor neurons, Interneurons, Medical Physiology, Neurology & Neurosurgery, Medical physiology
Abstract

The enteric nervous system (ENS) controls gastrointestinal functions. In large mammals' intestine, it comprises an inner (ISP) and outer (OSP) submucous plexus and a myenteric plexus (MP). This study quantifies enteric neurons in the ISP, OSP, and MP of the pig ascending (AC) and descending colon (DC) using the HuC/D, choline acetyltransferase (ChAT), and neuronal nitric oxide synthase (nNOS) neuronal markers in whole mount preparations with multiple labeling immunofluorescence. We established that the ISP contains the highest number of HuC/D neurons/mm2, which were more abundant in AC vs. DC, followed by OSP and MP with similar density in AC and DC. In the ISP, the density of ChAT immunoreactive (IR) neurons was very similar in AC and DC (31% and 35%), nNOS-IR neurons were less abundant in AC than DC (15% vs. 42%, P

Published
2021

5. Clinical and Pathological Features of Severe Gut Dysmotility

Author

Bianco, Francesca, Bonora, Elena, Lattanzio, Giulia, Clavenzani, Paolo, Guarino, Matteo, Mazzoni, Maurizio, Baldassarro, Vito Antonio, Lorenzini, Luca, Caio, Giacomo, Stanghellini, Vincenzo, Sternini, Catia, Farrugia, Gianrico, Giardino, Luciana, Calzà, Laura, De Giorgio, Roberto, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, Spencer, Nick J., editor, Costa, Marcello, editor, and Brierley, Stuart M., editor

Published
2022
Full Text
View/download PDF

7. Impact of Dry Aging on Quality Parameters and Microbiological Safety of Beef

Author

Savini, Federica, primary, Indio, Valentina, additional, Panseri, Sara, additional, Chiesa, Luca, additional, Negri, Armando, additional, Grassi Scalvini, Francesca, additional, De Cesare, Alessandra, additional, Mazzoni, Maurizio, additional, Clavenzani, Paolo, additional, Prandini, Laura, additional, Tomasello, Federico, additional, Terefe Mekonnen, Yitagele, additional, Giacometti, Federica, additional, and Serraino, Andrea, additional

Published
2024
Full Text
View/download PDF

8. Expression of the Bitter Taste Receptor, T2R38, in Enteroendocrine Cells of the Colonic Mucosa of Overweight/Obese vs. Lean Subjects.

Author

Latorre, Rocco, Huynh, Jennifer, Mazzoni, Maurizio, Gupta, Arpana, Bonora, Elena, Clavenzani, Paolo, Chang, Lin, Mayer, Emeran A, De Giorgio, Roberto, and Sternini, Catia

Subjects
Intestinal Mucosa, Colon, Humans, Obesity, Cholecystokinin, Peptide YY, Receptors, G-Protein-Coupled, RNA, Messenger, Adult, Middle Aged, Female, Male, Enteroendocrine Cells, Overweight, Glucagon-Like Peptide 1, Chromogranin A, Young Adult, RNA, Messenger, Receptors, G-Protein-Coupled, General Science & Technology
Abstract

Bitter taste receptors (T2Rs) are expressed in the mammalian gastrointestinal mucosa. In the mouse colon, T2R138 is localized to enteroendocrine cells and is upregulated by long-term high fat diet that induces obesity. The aims of this study were to test whether T2R38 expression is altered in overweight/obese (OW/OB) compared to normal weight (NW) subjects and characterize the cell types expressing T2R38, the human counterpart of mouse T2R138, in human colon. Colonic mucosal biopsies were obtained during colonoscopy from 35 healthy subjects (20 OW/OB and 15 NW) and processed for quantitative RT-PCR and immunohistochemistry using antibodies to T2R38, chromogranin A (CgA), glucagon like peptide-1 (GLP-1), cholecystokinin (CCK), or peptide YY (PYY). T2R38 mRNA levels in the colonic mucosa of OW/OB were increased (> 2 fold) compared to NW subjects but did not reach statistical significance (P = 0.06). However, the number of T2R38 immunoreactive (IR) cells was significantly increased in OW/OB vs. NW subjects (P = 0.01) and was significantly correlated with BMI values (r = 0.7557; P = 0.001). In both OW/OB and NW individuals, all T2R38-IR cells contained CgA-IR supporting they are enteroendocrine. In both groups, T2R38-IR colocalized with CCK-, GLP1- or PYY-IR. The overall CgA-IR cell population was comparable in OW/OB and NW individuals. This study shows that T2R38 is expressed in distinct populations of enteroendocrine cells in the human colonic mucosa and supports T2R38 upregulation in OW/OB subjects. T2R38 might mediate host functional responses to increased energy balance and intraluminal changes occurring in obesity, which could involve peptide release from enteroendocrine cells.

Published
2016

10. Effects of Bioactive Peptides from Atlantic Salmon Processing By-Products on Oxyntopeptic and Enteroendocrine Cells of the Gastric Mucosa of European Seabass and Gilthead Seabream

Author

Clavenzani, Paolo, primary, Lattanzio, Giulia, additional, Bonaldo, Alessio, additional, Parma, Luca, additional, Busti, Serena, additional, Oterhals, Åge, additional, Romarheim, Odd Helge, additional, Aspevik, Tone, additional, Gatta, Pier Paolo, additional, and Mazzoni, Maurizio, additional

Published
2023
Full Text
View/download PDF

13. Poly(l-lactic acid) Scaffold Releasing an α4β1 Integrin Agonist Promotes Nonfibrotic Skin Wound Healing in Diabetic Mice

Author

Baldassarro, Vito Antonio, primary, Giraldi, Valentina, additional, Giuliani, Alessandro, additional, Moretti, Marzia, additional, Pagnotta, Giorgia, additional, Flagelli, Alessandra, additional, Clavenzani, Paolo, additional, Lorenzini, Luca, additional, Giardino, Luciana, additional, Focarete, Maria Letizia, additional, Giacomini, Daria, additional, and Calzà, Laura, additional

Published
2022
Full Text
View/download PDF

15. The evolution of vimentin and desmin in Pectoralis major muscles of broiler chickens supports their essential role in muscle regeneration

Author

Soglia, Francesca, primary, Bordini, Martina, additional, Mazzoni, Maurizio, additional, Zappaterra, Martina, additional, Di Nunzio, Mattia, additional, Clavenzani, Paolo, additional, Davoli, Roberta, additional, Meluzzi, Adele, additional, Sirri, Federico, additional, and Petracci, Massimiliano, additional

Published
2022
Full Text
View/download PDF

26. Evidence of enteric angiopathy and neuromuscular hypoxia in patients with mitochondrial neurogastrointestinal encephalomyopathy

Author

Boschetti, Elisa, primary, D’Angelo, Roberto, additional, Tardio, Maria Lucia, additional, Costa, Roberta, additional, Giordano, Carla, additional, Accarino, Anna, additional, Malagelada, Carolina, additional, Clavenzani, Paolo, additional, Tugnoli, Vitaliano, additional, Caio, Giacomo, additional, Righi, Valeria, additional, Garone, Caterina, additional, D'Errico, Antonietta, additional, Cenacchi, Giovanna, additional, Dotti, Maria Teresa, additional, Stanghellini, Vincenzo, additional, Sternini, Catia, additional, Pironi, Loris, additional, Rinaldi, Rita, additional, Carelli, Valerio, additional, and De Giorgio, Roberto, additional

Published
2021
Full Text
View/download PDF

28. Aspetti Morfo-Fisiologici dell’Apparato Digerente nei Mammiferi

Author

Clavenzani, Paolo, Stanzani, Agnese <1990>, Clavenzani, Paolo, and Stanzani, Agnese <1990>

Abstract

La tesi verte sullo studio morfo-fisiologico e/o patologico del tratto gastrointestinale (GI) di mammiferi. La prima ricerca è basata sull’identificazione, attraverso metodiche di next generation sequencing, di geni coinvolti nell’insorgenza di acalasia sporadica nell’uomo. Tale patologia risulta caratterizzata dalla presenza di anomalie a carico di neuroni del plesso mienterico e cellule interstiziali di Cajal (ICC), che esita in una compromissione della peristalsi del tratto esofageo. É emerso che nei pazienti con acalasia vs controlli il gene C-KIT è down-regolato, mentre INPP4B è up-regolato. Questi geni risultano essere importanti per lo sviluppo e differenziamento neuronale e delle ICC. Il secondo argomento verte allo studio dei processi di de- e fosforilazione della proteina Tau in condizioni fisiologiche e neurodegenerative. Nell’Alzheimer si osserva un accumulo irreversibile di phospho-Tau che induce neurotossicità. Nell’encefalo di animali letargici la proteina Tau viene iperfosforilata in ipotermia, ma defosforila al rientro della normotermia. Inducendo torpore sintetico nel ratto si è osservato che nel sistema nervoso centrale e nel tratto gastrointestinale la phospho-Tau si accumula durante lo stato ipotermico, ma defosforila al ripristino delle temperature fisiologiche. Comprendere le modificazioni associate alla Tau può rappresentare un valido supporto per meglio comprendere quali meccanismi sono alterati in condizioni patologiche. L’ultima parte delle ricerche è stata finalizzata allo studio della distribuzione dei recettori per cannabinoidi quali CB1R, CB2R, GPR55, PPARα, PPARγ, TRPA1 e 5-HT1aR, nel tratto GI di gatto attraverso metodiche immunoistochimiche. Molti autori riportano come l’attivazione di questi recettori svolga un ruolo chiave nei processi infiammatorie ed in generale sulla sensibilità viscerale. La conoscenza della presenza e distribuzione di questi recettori può rappresentare un efficace contributo per future applicazioni in campo f, The thesis is focused on a morpho-physiological and pathological study on the gastrointestinal tract (GT) in mammals. The first research talks about the identification, through next generation sequencing, of new genes involved in human sporadic achalasia. This pathology is characterized by abnormalities in myenteric plexus neurons and interstitial cells of Cajal (ICC), that caused esophageal peristalsis impairment. This genetic analysis revealed that achalasia patients vs controls have a downregulation of C-KIT gene and an upregulation of INPP4B. these genes are really important for neuronal and ICC development and differentiation. The second research talks about the processes of de- and phosphorilation of Tau protein in physiological and neurodegenerative conditions. It has been observed that in Alzheimer disease there is an irreversible accumulation of Phospho-Tau that induces neuro-toxicity. In the brain of letargic animals there is a reversible accumulation of phospho-Tau in hypothermia, that is de-phosphorilated when the animals turns to normothermia. It has been observed in a rat artificial model of syntetic torpor that phospho-Tau is accumulated in brain and GT during the hypothermic state, and it’s completely de-phosphorilated turning into normothermia. Understanding the meaning of these modifications associated with Tau protein could be a good tool to discover the mechanisms alterated in pathological neurodegenerative conditions. The third research talks about the distribution on cannabinoid receptors in the cat GI through immunohistochemistry. The receptors studied are CB1R, CB2R, GPR55, PPARα, PPARγ, TRPA1 e 5HT1-aR. Many authors stated that the activation of these receptors has a key role in inflammatory processes and in visceral sensibility. The knowledge of the distribution of these receptors could be helpful for the application in a phamacological/therapeutical field. The last part of the thesis contains all the other projects where I joined, most of

Published
2020

33. Quantitative analysis of enteric neurons containing choline acetyltransferase and nitric oxide synthase immunoreactivities in the submucosal and myenteric plexuses of the porcine colon

Author

Mazzoni, Maurizio, primary, Caremoli, Filippo, additional, Cabanillas, Luis, additional, de los Santos, Janira, additional, Million, Mulugeta, additional, Larauche, Muriel, additional, Clavenzani, Paolo, additional, De Giorgio, Roberto, additional, and Sternini, Catia, additional

Published
2020
Full Text
View/download PDF

35. Quantitative analysis of enteric neurons containing choline acetyltransferase and nitric oxide synthase immunoreactivities in the submucosal and myenteric plexuses of the porcine colon v1

Author

Mazzoni, Maurizio, primary, Caremoli, Filippo, additional, Cabanillas, Luis, additional, de, Janira, additional, Million, Mulugeta, additional, Larauche, Muriel, additional, Clavenzani, Paolo, additional, De, Roberto, additional, and Sternini, Catia, additional

Published
2020
Full Text
View/download PDF

40. Enteric neuron density correlates with clinical features of severe gut dysmotility

Author

Boschetti, Elisa, primary, Malagelada, Carolina, additional, Accarino, Anna, additional, Malagelada, Juan R., additional, Cogliandro, Rosanna F., additional, Gori, Alessandra, additional, Bonora, Elena, additional, Giancola, Fiorella, additional, Bianco, Francesca, additional, Tugnoli, Vitaliano, additional, Clavenzani, Paolo, additional, Azpiroz, Fernando, additional, Stanghellini, Vincenzo, additional, Sternini, Catia, additional, and De Giorgio, Roberto, additional

Published
2019
Full Text
View/download PDF

41. Gut epithelial and vascular barrier abnormalities in patients with chronic intestinal pseudo‐obstruction

Author

Boschetti, Elisa, primary, Accarino, Anna, additional, Malagelada, Carolina, additional, Malagelada, Juan R., additional, Cogliandro, Rosanna F., additional, Gori, Alessandra, additional, Tugnoli, Vitaliano, additional, Giancola, Fiorella, additional, Bianco, Francesca, additional, Bonora, Elena, additional, Clavenzani, Paolo, additional, Volta, Umberto, additional, Caio, Giacomo, additional, Sternini, Catia, additional, Stanghellini, Vincenzo, additional, Azpiroz, Fernando, additional, and De Giorgio, Roberto, additional

Published
2019
Full Text
View/download PDF

43. New Insights into Molecular Mechanisms of Enteric Neuro-Epithelial Pathology: From Damage to Protection

Author

Clavenzani, Paolo, Bianco, Francesca <1984>, Clavenzani, Paolo, and Bianco, Francesca <1984>

Abstract

Backgrond: Functional gastrointestinal disorders (FGID) are chronic conditions characterized by symptoms for which no overt organic cause can be found. They affect up to 20% of western populations with evidence suggesting they are equally common in the Third World (Spiller 2005). Although symptoms are generally mild or moderate, a small subset of cases shows severe manifestations, i.e. nausea, vomiting, bloating, abdominal distension, intractable constipation and chronic pain, with such an intensity hampering normal feeding and compromising considerably patients’ quality of life. In addition, this subset of patients may also have recurrent intestinal sub-occlusive episodes, which occur in the absence of demonstrable mechanical causes, leading to numerous hospitalizations as well as useless and potentially harmful surgical interventions. This condition is referred to as chronic intestinal pseudo-obstruction (CIPO), a rare and intractable chronic digestive disease with symptoms and signs of intestinal obstruction without demonstrable mechanical cause. CIPO can result from derangements affecting the integrity of a variety of regulatory cells/tissues, i.e. smooth muscle cells, the interstitial cells of Cajal (ICC) (pace-makers of gut motility), and neurons (either intrinsic – the enteric nervous system- or extrinsic nerve pathways). Aims and experimental studies: The present thesis was conceived to provide a thorough account of the molecular defects underlying CIPO and highlight new strategies of neuro-epithelial protection to prevent enteric neurodegeneration. The experimental studies are based on genetic analysis of CIPO patients and characterization of RAD21 in the ENS of human and mouse intestine. Other studies are focus on 5-hydroxytryptamine-4 (5-HT4) receptor particularly studying whether the activation of colonic epithelial 5-HT4 protects against experimentally induced inflammation of the mouse colon. Conclusion: My thesis focuses on both mechanisms of neurodege

Published
2018

44. Interdisciplinary Approach to Teaching: How Economics Can Benefits?

Author

ARAGRANDE, MAURIZIO, STANCAMPIANO, LAURA, PAGLIARANI, ALESSANDRA, BOMBARDI, CRISTIANO, CHIOCCHETTI, ROBERTO, CLAVENZANI, PAOLO, CANALI, MASSIMO, DALL'OLIO, STEFANIA, GUARNIERO, ILARIA, ISANI, GLORIA, TASSINARI, MARCO, TROMBETTI, FABIANA, Bouda Vosough Ahmadi , Jonathan Rushton , Barbara Haesler , George John Gunn and Henk Hogeveen, Maurizio Aragrande, Laura Stancampiano, Alessandra Pagliarani, Cristiano Bombardi, Roberto Chiocchetti, Paolo Clavenzani, Massimo Canali, Stefania Dall’Olio, Ilaria guarniero, Gloria Isani, Marco Tassinari, and Fabiana Trombetti

Subjects
education, Interdisciplinarity, Veterinary students
Abstract

Veterinary students tend to disregard some disciplines in favour of those directly involved in the medical and clinical practice resulting in low course attendance and poor learning outcomes. To increase discipline’s attractiveness, an experiment of interdisciplinary teaching was developed at the Veterinary Faculty of the University of Bologna in 2016

Published
2017

45. Novel Mutations in Neurogenic Chronic Intestinal Pseudo-Obstruction Identified by High-Throughput Sequencing

Author

Bonora, Elena, primary, Bianco, Francesca, additional, Agnese, Stanzani, additional, Diquigiovanni, Chiara, additional, Rinaldi, Rita, additional, D'Angelo, Roberto, additional, Cogliandro, Rosanna, additional, Smith, Joshua D., additional, Nickerson, Deborah, additional, Bamshad, Mike, additional, Assadi, Ghazaleh, additional, Clavenzani, Paolo, additional, Lindberg, Greger, additional, D'Amato, Mauro, additional, Graziano, Claudio, additional, Stanghellini, Vincenzo, additional, Seri, Marco, additional, and De Giorgio, Roberto, additional

Published
2017
Full Text
View/download PDF

48. Effect of Mucine 4 and Fucosyltransferase 1 genetic variants on gut homoeostasis of growing healthy pigs.

Author

Luise, Diana, Motta, Vincenzo, Bertocchi, Micol, Salvarani, Chiara, Clavenzani, Paolo, Fanelli, Flaminia, Pagotto, Uberto, Bosi, Paolo, and Trevisi, Paolo

Subjects
SWINE, GUT microbiome, GENETIC markers, BLOOD plasma, GENE expression, INTESTINAL mucosa
Abstract

Putative genetic markers have been associated with ETEC F4 (Mucine 4 [MUC4]; MUC4GG;CG as susceptible; MUC4CC as resistant) and F18 (Fucosyltransferase 1 [FUT1]; FUT1GG;AG as susceptible; FUT1AA as resistant) resistances respectively. In this study, 71 post‐weaning pigs were followed from d0 (35 days old) to d42 (77 days of age) to investigate the effect of MUC4 or FUT1 genotypes on the mid‐jejunal microbiota composition, pigs expression of genes related to inflammation (IL8, GPX2, REG3G, TFF3, CCL20 and LBPI) and glycomic binding pattern profile (Ulex europaeus agglutinin I [UEA] fucose‐binding lectin and peanut agglutinin [PNA] galactose‐specific), and on blood plasma targeted metabolomics profile, faecal score and performance parameters of growing healthy pigs. The MUC4 and FUT1 resistant genotypes improved the pigs' growth performance and had firmed faecal score susceptible genotypes in d0–d21 period. Pigs with MUC4GG genotype had a higher jejunal expression of genes relate to immune function (CCL20 and REG3G) than MUC4CG and MUC4CC pigs (p < 0.05). MUC4CG pigs had higher expression of TFF3 (implicated in mucosal integrity) than MUC4GG and MUC4CC (p < 0.05). FUT1 influenced the alpha‐ and beta‐jejunal microbial indices. The FUT1AA group had a higher number of operational taxonomic units (OTUs) belonging to Lactobacillus genus, while FUT1GG group had a higher number of OTUs belonging to Veillonella genus. MUC4CC pigs had lower scores for UEA on brush borders and goblet cells in villi than MUC4GG (p < 0.05). FUT1AA pigs had lower UEA positivity and higher PNA positivity on brush borders and goblet cells than FUT1AG and FUT1GG (p < 0.05). Both FUT1 and MUC4 influenced the metabolic profile of healthy pigs. Results highlight the role of MUC4 and FUT1 on pig intestinal homoeostasis and improved the knowledge regarding the potential interaction between host genetics, gut microbiota composition and host metabolism in a healthy status. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

49. CLINICAL AND NEUROCHEMICAL FEATURES OF CHRONIC CONSTIPATION IN PATIENTS WITH PARKINSON DISEASE

Author

GIANCOLA, FIORELLA, LATORRE, ROCCO, SORTENI, CATERINA, BARBARA, GIOVANNI, CREMON, CESARE, CHIOCCHETTI, ROBERTO, CLAVENZANI, PAOLO, STANGHELLINI, VINCENZO, DE GIORGIO, ROBERTO, Torresan, F., Ioannou, A., Guarino, M., Vallorani, C., Sternini, C., Giancola, F., Latorre, R., Sorteni, C., Torresan, F., Ioannou, A., Guarino, M., Barbara, G., Cremon, C., Chiocchetti, R., Vallorani, C., Clavenzani, P., Stanghellini, V., Sternini, C., and De Giorgio, R.

Subjects
CHRONIC CONSTIPATION, PARKINSON DISEASE
Published
2014

50. A PIONEER OF ITALIAN NEUROSCIENCE: THE ACADEMIC LIFE OF RUGGERO BORTOLAMI

Author

CLAVENZANI, PAOLO, CHIOCCHETTI, ROBERTO, GRANDIS, ANNAMARIA, BOMBARDI, CRISTIANO, MAZZONI, MAURIZIO, N. De Sordi, F. Rambaldi, DE GIORGIO, ROBERTO, P. Clavenzani, R. Chiocchetti, A. Grandi, C. Bombardi, M. Mazzoni, N. De Sordi, F. Rambaldi, and R. De Giorgio.

Abstract

Ruggero Bortolami, emeritus professor of Systematic and Comparative Veterinary Anatomy of the University of Bologna, passed away in July 2014 after a long life spent loving from the bottom of his hearth anatomy and neuroscience in most of its aspects. He was born in Padua on June 30, 1926 and in 1949 he graduated with honors in Veterinary Medicine at the University of Bologna. In 1959 he became full professor of Veterinary Anatomy at the University of Sassari and in 1968 and then he moved to the University of Bologna as professor of Systematic and Comparative Veterinary Anatomy, a position he held until his retirement in 1999. During his long and prestigious career Prof. Bortolami studied several topics including proprioception of the eye muscles; the morphological and functional relationships between the trigeminal nerve and the motor nerves of the eye and the synapses of primary afferents neurons, via the ventral roots of the spinal cord. His activity resulted in about 350 papers mainly in international peer-reviewed journals. He was the Editor of the Italian version of the Robert Barone treatise of veterinary anatomy and co-Author of the volume dedicated to the central nervous system. He funded the Italian Association of Veterinarian Morphologists and became member of several national and international scientific societies, e.g., the World Association of Veterinary Anatomists, of which he was Vice President from 1971 to 1973. We owe him a lot for launching and co-founding our beloved Italian Group for the Study of Neuromorphology (GISN) that he continued to support in any circumstances, with his high reputation and strong intellectual energy. The GISN will always remember Prof. Bortolami forever for his outstanding scientific achievements and devoted passion for science to innovation and progression of comparative anatomy and neuroscience. We are proud to be in his scientific legacy.

Published
2014

Catalog

Books, media, physical & digital resources
See catalog results