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1,039 results on '"CLAAS, F."'

2. A paired-kidney allocation study found superior survival with HLA-DR compatible kidney transplants in the Eurotransplant Senior Program

Author

Fijter, J. de, Dreyer, G., Mallat, M., Budde, K., Pratschke, J., Klempnauer, J., Zeier, M., Arns, W., Hugo, C., Rump, L.C., Hauser, I., Schenker, P., Schiffer, M., Grimm, M.O., Kliem, V., Olbricht, C.J., Pisarski, P., Banas, B., Suwelack, B., Hakenberg, O., Berlakovich, G., Schneeberger, S., Wetering, J. van de, Berger, S., Bemelman, F., Kuypers, D., Heidt, S., Rahmel, A., Claas, F., Peeters, P., Oberbauer, R., Hilbrands, L.B., Heemann, U., Krämer, B.K., Fijter, J. de, Dreyer, G., Mallat, M., Budde, K., Pratschke, J., Klempnauer, J., Zeier, M., Arns, W., Hugo, C., Rump, L.C., Hauser, I., Schenker, P., Schiffer, M., Grimm, M.O., Kliem, V., Olbricht, C.J., Pisarski, P., Banas, B., Suwelack, B., Hakenberg, O., Berlakovich, G., Schneeberger, S., Wetering, J. van de, Berger, S., Bemelman, F., Kuypers, D., Heidt, S., Rahmel, A., Claas, F., Peeters, P., Oberbauer, R., Hilbrands, L.B., Heemann, U., and Krämer, B.K.

Abstract

Item does not contain fulltext, The Eurotransplant Senior Program (ESP) has expedited the chance for elderly patients with kidney failure to receive a timely transplant. This current study evaluated survival parameters of kidneys donated after brain death with or without matching for HLA-DR antigens. This cohort study evaluated the period within ESP with paired allocation of 675 kidneys from donors 65 years and older to transplant candidates 65 years and older, the first kidney to 341 patients within the Eurotransplant Senior DR-compatible Program and 334 contralateral kidneys without (ESP) HLA-DR antigen matching. We used Kaplan-Meier estimates and competing risk analysis to assess all cause mortality and kidney graft failure, respectively. The log-rank test and Cox proportional hazards regression were used for comparisons. Within ESP, matching for HLA-DR antigens was associated with a significantly lower five-year risk of mortality (hazard ratio 0.71; 95% confidence interval 0.53-0.95) and significantly lower cause-specific hazards for kidney graft failure and return to dialysis at one year (0.55; 0.35-0.87) and five years (0.73; 0.53-0.99) post-transplant. Allocation based on HLA-DR matching resulted in longer cold ischemia (mean difference 1.00 hours; 95% confidence interval: 0.32-1.68) and kidney offers with a significantly shorter median dialysis vintage of 2.4 versus 4.1 yrs. in ESP without matching. Thus, our allocation based on HLA-DR matching improved five-year patient and kidney allograft survival. Hence, our paired allocation study suggests a superior outcome of HLA-DR matching in the context of old-for-old kidney transplantation.

Published
2023

22. Evidence that cyclosporin A prevents clinical cardiac allograft rejection by blocking both direct and indirect antigen presentation pathways

Author

van Besouw, N. M., Vaessen, L. M. B., Knoop, C. J., Weimar, W., Balk, A. H. M. M., Mochtar, B., Claas, F. H. J., Mühlbacher, Ferdinand, editor, Gnant, M., editor, Klepetko, W., editor, Längle, F., editor, Laufer, G., editor, Sautner, T., editor, Steininger, R., editor, Wamser, P., editor, and Kootstra, G., editor

Published
1996
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25. Improve in-depth immunological risk assessment to optimize genetic-compatibility and clinical outcomes in child and adolescent recipients of parental donor kidney transplants: protocol for the INCEPTION study

Author

Lim, WH, Adams, B, Alexander, S, Bouts, AHM, Claas, F, Collins, M, Cornelissen, E, Dunckley, H, de Jong, H, D'Orsogna, L, Francis, A, Heidt, S, Herman, J, Holdsworth, R, Kausman, J, Khalid, R, Kim, JJ, Kim, S, Knops, N, Kosmoliaptsis, V, Kramer, C, Kuypers, D, Larkins, N, Palmer, SC, Prestidge, C, Prytula, A, Sharma, A, Shingde, M, Taverniti, A, Teixeira-Pinto, A, Trnka, P, Willis, F, Wong, D, Wong, G, Lim, WH, Adams, B, Alexander, S, Bouts, AHM, Claas, F, Collins, M, Cornelissen, E, Dunckley, H, de Jong, H, D'Orsogna, L, Francis, A, Heidt, S, Herman, J, Holdsworth, R, Kausman, J, Khalid, R, Kim, JJ, Kim, S, Knops, N, Kosmoliaptsis, V, Kramer, C, Kuypers, D, Larkins, N, Palmer, SC, Prestidge, C, Prytula, A, Sharma, A, Shingde, M, Taverniti, A, Teixeira-Pinto, A, Trnka, P, Willis, F, Wong, D, and Wong, G

Abstract

BACKGROUND: Parental donor kidney transplantation is the most common treatment option for children and adolescents with kidney failure. Emerging data from observational studies have reported improved short- and medium-term allograft outcomes in recipients of paternal compared to maternal donors. The INCEPTION study aims to identify potential differences in immunological compatibility between maternal and paternal donor kidneys and ascertain how this affects kidney allograft outcomes in children and adolescents with kidney failure. METHODS: This longitudinal observational study will recruit kidney transplant recipients aged ≤18 years who have received a parental donor kidney transplant across 4 countries (Australia, New Zealand, United Kingdom and the Netherlands) between 1990 and 2020. High resolution human leukocyte antigen (HLA) typing of both recipients and corresponding parental donors will be undertaken, to provide an in-depth assessment of immunological compatibility. The primary outcome is a composite of de novo donor-specific anti-HLA antibody (DSA), biopsy-proven acute rejection or allograft loss up to 60-months post-transplantation. Secondary outcomes are de novo DSA, biopsy-proven acute rejection, acute or chronic antibody mediated rejection or Chronic Allograft Damage Index (CADI) score of > 1 on allograft biopsy post-transplant, allograft function, proteinuria and allograft loss. Using principal component analysis and Cox proportional hazards regression modelling, we will determine the associations between defined sets of immunological and clinical parameters that may identify risk stratification for the primary and secondary outcome measures among young people accepting a parental donor kidney for transplantation. This study design will allow us to specifically investigate the relative importance of accepting a maternal compared to paternal donor, for families deciding on the best option for donation. DISCUSSION: The INCEPTION study findings will explo

Published
2021

45. Minor H antigen matches and mismatches are equally distributed among recipients with or without complications after HLA identical sibling renal transplantation

Author

Dierselhuis, M. P., Spierings, E., Drabbels, J., Hendriks, M., Alaez, C., Alberú, J., Alvarez, M. B., Burlingham, W., Campos, E., Christiaans, M., Claas, F., Fasano, M. E., Gerbase-DeLima, M., Gervais, T., Gorodezky, C., Larriba, J., Lardy, N. M., Latinne, D., Morales-Buenrostro, L.-E., Moreno, M. J., Oguz, F., Opelz, G., Sergeant, R., Tambutti, M., Teper, S., Tilanus, M., Turkmen, A., Warrens, A. N., Weimar, W., and Goulmy, E.

Published
2013
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