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3 results on '"CHUK protein"'

1. The I kappa B kinase is a key factor in triggering influenza A virus-induced inflammatory cytokine production in airway epithelial cells

Author

M. Gabriella Santoro, Carla Amici, Angela Ianaro, Simone La Frazia, and Daniela Bernasconi

Subjects
Chemokine, Epidemiology, Molecular biology, medicine.medical_treatment, Overabundant production, Electrophoretic Mobility Shift Assay, IκB kinase, Epithelial cells, medicine.disease_cause, Biochemistry, respiratory epithelium, Influenza A virus, Pathology, cytokine, virus infection, animal, primer DNA, enzyme inhibition, Lung, biology, article, NF-kappa B, cell line, lung alveolus epithelium, Protein-Serine-Threonine Kinases, Settore MED/07 - Microbiologia e Microbiologia Clinica, Enzymes, enzyme activity, virology, I-kappa B Kinase, Cytokine, immunoglobulin enhancer binding protein, priority journal, I kappa B kinase, Viruses, dog, cytokine production, IKBKE protein, medicine.symptom, Inflammation Mediators, influenza, autacoid, Cells, cell specificity, Inflammation, interleukin 8, Protein Serine-Threonine Kinases, Influenza virus A, gel mobility shift assay, Virus, Proinflammatory cytokine, Dogs, Cytology, Influenza, Proinflammatory cytokines, delta12 prostaglandin J2, CHUK protein, human, IKBKB protein, human, IKBKE protein, human, protein serine threonine kinase, controlled study, enzyme activation, epithelium cell, human, human cell, inflammation, protein expression, biosynthesis, cytology, lung, metabolism, nucleotide sequence, Influenza virus, Animals, Base Sequence, Cell Line, DNA Primers, Humans, Interleukin-8, medicine, A549 cell, Cell Biology, CHUK protein, IKBKB protein, Immunology, biology.protein
Abstract

Influenza A viruses continue to represent a severe threat worldwide, causing large epidemics and pandemics responsible for thousands of deaths every year. Excessive inflammation due to overabundant production of proinflammatory cytokines by airway epithelial cells is considered an important factor in disease pathogenesis. Here we report that influenza A virus induced IkappaB kinase (IKK) activity in human airway epithelial A549 cells, resulting in persistent activation of nuclear factor-kappaB (NF-kappaB), a critical regulator of the inflammatory response. Although lung epithelial cells are highly sensitive to stimulation of the IKK/NF-kappaB pathway by influenza virus infection, NF-kappaB was not activated in several non-pulmonary cells permissive to the virus, indicating a cell-specific response. Moreover, NF-kappaB was not essential for virus replication but triggered the expression of proinflammatory cytokines in infected lung cells and was directly responsible for production of high levels of interleukin-8, a chemokine associated with influenza-induced inflammation and airway pathology. We also report that 9-deoxy-delta9,delta12-13,14-dihydro-prostaglandin D2, a cyclopentenone prostanoid with therapeutic efficacy against influenza in preclinical studies, was a powerful inhibitor of influenza virus-induced IKK activity and interleukin-8 production by human pulmonary cells. The results identify IKK as an important factor in triggering influenza virus-induced inflammatory reactions in pulmonary epithelium, suggesting novel therapeutic approaches in the treatment of influenza.

Published
2005

2. A hypermorphic I kappa B alpha mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency

Author

Courtois, G, Smahi, A, Reichenbach, J, Doffinger, R, Cancrini, C, Bonnet, M, Puel, A, Chable Bessia, C, Yamaoka, S, Feinberg, J, Dupuis Girod, S, Bodemer, C, Livadiotti, S, Novelli, F, Rossi, P, Fischer, A, Israel, A, Munnich, A, Le Deist, F, and Casanova, Jl

Subjects
Male, CD40 ligand, complementary DNA, cytokine, genomic DNA, I kappa B alpha, I kappa B kinase, I kappa B kinase gamma, immunoglobulin enhancer binding protein, interleukin 18, interleukin 1beta, T lymphocyte receptor, tumor necrosis factor alpha, tumor necrosis factor receptor, unclassified drug, CHUK protein, human, I kappa B, I kappa B beta, IKBKB protein, human, IKBKE protein, human, lymphocyte antigen receptor, protein serine threonine kinase, anhidrosis, anhidrotic ectodermal dysplasia, article, autosomal dominant disorder, case report, cellular immunity, controlled study, disease association, ectodermal dysplasia, gene, gene mutation, human, human cell, IKBA gene, immune deficiency, immunogenetics, infant, male, priority journal, T lymphocyte, X chromosome linked disorder, child, genetic transcription, genetics, immunology, mutation, physiology, signal transduction, Child, Ectodermal Dysplasia, Humans, I-kappa B Kinase, I-kappa B Proteins, Immunologic Deficiency Syndromes, Mutation, NF-kappa B, Protein-Serine-Threonine Kinases, Receptor-CD3 Complex, Antigen, T-Cell, Signal Transduction, T-Lymphocytes, Transcription, Genetic, Tumor Necrosis Factor-alpha, Receptor-CD3 Complex, Antigen, IKBKE protein, Transcription, Genetic, Settore MED/38 - Pediatria Generale e Specialistica, CHUK protein, T-Cell, IKBKB protein
Published
2003

3. Activation of I kappa B kinase by herpes simplex virus type 1 - A novel target for anti-herpetic therapy

Author

Amici, C, Belardo, G, Rossi, A, and Santoro, Mg

Subjects
antivirus agent, Human herpesvirus 1, protein synthesis, larynx tumor, Anti-Inflammatory Agents, Acyclovir, prostaglandin A, Virus Replication, Biochemistry, Neuroblastoma, Methionine, nonsteroid antiinflammatory agent, cytokine, virus infection, Simplexvirus, animal, genetics, Cycloheximide, Enzyme Inhibitors, transcription factor, Cultured, Herpes simplex virus 1, drug effect, article, NF-kappa B, gene control, gene expression regulation, Chemical activation, Protein-Serine-Threonine Kinases, Settore MED/07 - Microbiologia e Microbiologia Clinica, Recombinant Proteins, Enzymes, I-kappa B Kinase, Tumor Cells, immunoglobulin enhancer binding protein, Fungal, priority journal, I kappa B kinase, Viruses, Dactinomycin, IKBKE protein, Non-Steroidal, Derivatives, signal transduction, Human, drug design, enzyme inhibitor, Cercopithecus, Biosynthesis, Transfection, Antiviral Agents, Cercopithecus aethiops, protein serine threonine kinase, Transcription factors, Animals, Humans, controlled study, Laryngeal Neoplasms, Vero Cells, cell culture, Prostaglandins A, Vero cell, Herpesvirus 1, human cell, prostaglandin A1, Drug products, enzyme activation, CHUK protein, Genes, Gene expression, aciclovir, cyclopentanone derivative, CHUK protein, human, cycloheximide, dactinomycin, IKBKB protein, human, IKBKE protein, human, methionine, recombinant protein, gene expression, human, inflammation, virus replication, genetic transfection, kinetics, metabolism, neuroblastoma, physiology, DNA viruses, Anti-Inflammatory Agents, Non-Steroidal, Drug Design, Enzyme Activation, Gene Expression Regulation, Fungal, Herpesvirus 1, Human, Kinetics, Tumor Cells, Cultured, IKBKB protein
Published
2001

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