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Your search keyword '"CHIARI, ERMANNA"' showing total 137 results
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137 results on '"CHIARI, ERMANNA"'

6. 278 Cardiac involvement in a 23 years old patient with granulomatosis with polyangiitis (GPA)

Author

Cimino, Giuliana, Colombo, Giada, Bellicini, Maria Giulia, Amore, Ludovica, Cersosimo, Angelica, Mario Lombardi, Carlo, Vizzardi, Enrico, Raddino, Riccardo, Danesi, Rossella, Chiari, Ermanna, Gregorini, Gina, and Metra, Marco

Subjects
Vessel Diseases, AcademicSubjects/MED00200, Cardiology and Cardiovascular Medicine
Abstract

Aims Granulomatosis with polyangiitis (GPA) is a systemic necrotizing vasculitis, which could potentially affect any organ system. However, there have only been a few reports on cardiac involvement. In fact, it most commonly involves the sinuses, lungs, and kidneys with necrotizing granulomatous vasculitis. In 12% of a large series of patients with GPA there was cardiac involvement, largely manifested by pericarditis and coronary arteritis. Methods and results We describe a rare case of a 23-year-old girl, with no pathological history, at exception of a recent flu-like syndrome for which she carried out the search for SARS-CoV-2 RNA through nasopharyngeal swab, results negative. After a month, she went to the emergency department for a syncopal episode and subsequent head trauma. On this occasion, echocardiogram performed showed the presence of left ventricular systolic dysfunction due to hypokinesia of the middle distal segments; CT angiography of the chest revealed the presence of pulmonary embolism. For this reason, the patient was admitted to the cardiac intensive care unit, where EKG shown anterolateral myocardial infarction with ST elevation and immediately was performed coronary angiography, that evidenced two-vessel disease, with subsequent ineffective attempt to angioplasty. Due to the intercurrent appearance of hyposthenia and paraesthesia in the left upper limb, CT angiography of the brain was performed with detection of lower right pre central frontal hypodensity, suspected for recent ischaemic lesion and hypodensity of the right carotid artery as recent thrombosis. In light of the multi-organ involvement of ischaemic nature and the young age of the patient, rheumatological evaluation was carried out, with execution of a laboratory tests that showed the presence of positivity for ANCA anti-PR3 antibodies, on the basis of which was diagnosed GPA, and rituximab therapy was immediately initiated, with clinical benefit. Conclusions Cardiac involvement of GPA was first reported by Wegener in 1936. Classical or generalized GPA is characterized by necrotizing granulomatous vasculitis of the upper and lower respiratory tract together with glomerulonephritis. Widespread disseminated vasculitis involving both small arteries and veins occurs to a greater or lesser degree as the disease progresses. A localized form of GPA limited primarily to the upper and lower respiratory tracts has been described. Despite histopathological diagnosis of GPA, with autoantibodies against to circulatory neutrophilic cytoplasmic antigens, we can diagnose GPA easily and early. GPA must be kept in mind as the differential diagnosis of new onset cardiomyopathy, especially in the existence of pulmonary and renal pathologies. The clinical presentation of GPA can be so diverse that the list of differential diagnoses is vast, ranging from infections (fungal, bacterial, and mycobacterial) to other vasculitides, including Henoch–Schönlein purpura, sarcoidosis, Behcet syndrome, and malignancies. Despite that involving the heart is well described, significant cardiac complications occurring during the course of the disease are rare.

Published
2021

7. 261 A case of metastatic myxoid liposarcoma causing cardiac tamponade

Author

Cimino, Giuliana, primary, Bisegna, Stefano, additional, Cersosimo, Angelica, additional, Amore, Ludovica, additional, Vizzardi, Enrico, additional, Lombardi, Carlo Mario, additional, Raddino, Riccardo, additional, Danesi, Rossella, additional, Chiari, Ermanna, additional, Repossini, Alberto, additional, and Metra, Marco, additional

Published
2021
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13. Left ventricular reverse remodelling predicts long‐term outcomes in patients with functional mitral regurgitation undergoing MitraClip therapy: results from a multicentre registry

Author

Adamo, Marianna, primary, Godino, Cosmo, additional, Giannini, Cristina, additional, Scotti, Andrea, additional, Liga, Riccardo, additional, Curello, Salvatore, additional, Fiorina, Claudia, additional, Chiari, Ermanna, additional, Chizzola, Giuliano, additional, Abbenante, Alessandro, additional, Visco, Emanuele, additional, Branca, Luca, additional, Fiorelli, Francesca, additional, Agricola, Eustachio, additional, Stella, Stefano, additional, Lombardi, Carlo, additional, Colombo, Antonio, additional, Petronio, Anna Sonia, additional, Metra, Marco, additional, and Ettori, Federica, additional

Published
2018
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15. Self-expanding transcatheter aortic valve implantation for degenerated small Mitroflow bioprosthesis: early and midterm outcomes

Author

Adamo, Marianna, primary, Fiorina, Claudia, additional, Curello, Salvatore, additional, Chizzola, Giuliano, additional, Pezzotti, Elena, additional, Gavazzi, Emanuele, additional, Branca, Luca, additional, Chiari, Ermanna, additional, Quinzani, Filippo, additional, Rinaldi, Michele, additional, Metra, Marco, additional, and Ettori, Federica, additional

Published
2017
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16. Mitraclip therapy in patients with functional mitral regurgitation and missing leaflet coaptation: is it still an exclusion criterion?

Author

Adamo, Marianna, Chiari, Ermanna, Curello, Salvatore, Maiandi, Cristian, Chizzola, Giuliano, Fiorina, Claudia, Frontini, Mario, Cuminetti, Giovanni, Pezzotti, Elena, Rovetta, Riccardo, Lombardi, Carlo Mario, Manzato, Aldo, Metra, Marco, and Ettori, Federica

Subjects
Heart Valve Prosthesis Implantation, Male, Mitraclip implantation, Mitral Valve Insufficiency, Functional mitral regurgitation, Leaflet coaptation, Long-term outcome, Middle Aged, Surgical Instruments, Heart Valves, Treatment Outcome, Heart Valve Prosthesis, Humans, Mitral Valve, Female, Aged, Retrospective Studies
Abstract

The aim of this study was to investigate the feasibility, safety, and efficacy of Mitraclip therapy in patients with functional mitral regurgitation (MR) and missing leaflet coaptation (MLC).Out of 62 consecutive patients with functional MR undergoing Mitraclip implantation, 22 had MLC defined as the presence of a 'gap' between two mitral leaflets or insufficient coaptation length (2 mm), according to the EVEREST II criterion. Compared with the control group, the MLC population had a significantly higher effective regurgitant orifice area (0.67 ± 0.31 vs. 0.41 ± 0.13 cmThe Mitraclip procedure could be extended to patients with functional MR who do not fulfil the coaptation length EVEREST II criterion and who would otherwise be excluded from this treatment.

Published
2015

17. Left ventricular reverse remodelling predicts long-term outcomes in patients with functional mitral regurgitation undergoing MitraClip therapy: results from a multicentre registry.

Author

Adamo, Marianna, Godino, Cosmo, Giannini, Cristina, Scotti, Andrea, Liga, Riccardo, Curello, Salvatore, Fiorina, Claudia, Chiari, Ermanna, Chizzola, Giuliano, Abbenante, Alessandro, Visco, Emanuele, Branca, Luca, Fiorelli, Francesca, Agricola, Eustachio, Stella, Stefano, Lombardi, Carlo, Colombo, Antonio, Petronio, Anna Sonia, Metra, Marco, and Ettori, Federica

Subjects
MITRAL valve insufficiency, VENTRICULAR remodeling, HEART failure, ELECTRONIC publications, LEFT heart ventricle, COMPARATIVE studies, ECHOCARDIOGRAPHY, HEART physiology, HEART ventricles, PROSTHETIC heart valves, LONGITUDINAL method, RESEARCH methodology, MEDICAL cooperation, PROGNOSIS, PROSTHETICS, RESEARCH, TIME, EVALUATION research, TREATMENT effectiveness, ACQUISITION of data, RETROSPECTIVE studies
Abstract

Aims: To explore whether left ventricular reverse remodelling (LVRR) is a predictor of outcomes in patients with functional mitral regurgitation (FMR) undergoing MitraClip procedure.Methods and Results: We analysed 184 consecutive patients with FMR who underwent successful MitraClip procedure. LVRR was defined as a reduction in left ventricular end-systolic volume ≥ 10% from baseline to 6 months. LVRR was observed in 79 (42.9%) patients. Compared with non-LVRR, LVRR patients were more likely to be females, less likely to have an ischaemic aetiology of mitral regurgitation or a prior (<6 months) heart failure (HF) hospitalization, and had smaller left ventricular dimensions. New York Heart Association class improved from baseline up to 1-year follow-up in both groups. Higher rates of overall survival (87.3% vs. 75.2%, P = 0.039), freedom from HF hospitalization (77.2% vs. 60%, P = 0.020), and freedom from the composite endpoint (cardiovascular mortality or HF hospitalization) (74.7% vs. 55.2%; P = 0.012) were observed in LVRR vs. non-LVRR patients at 2-year follow-up. LVRR was associated with a significant reduction of the adjusted relative risk of mortality, HF hospitalization and composite endpoint [hazard ratio (HR) 0.44; 95% confidence interval (CI) 0.20-0.96, P = 0.040; HR 0.55; 95% CI 0.32-0.97, P = 0.038; and HR 0.54; 95% CI 0.32-0.92, P = 0.023, respectively]. Female gender, absence of diabetes, freedom from prior HF hospitalization, non-ischaemic aetiology of mitral regurgitation, and left ventricular end-diastolic diameter < 75 mm were found to be independent predictors of LVRR.Conclusions: Left ventricular reverse remodelling is associated with better long-term outcomes in patients with FMR successfully treated with MitraClip. A careful patient selection may be useful as specific baseline features predict favourable left ventricular remodelling. [Correction added on 17 January 2019, after online publication: the preceding sentence has been changed.]. [ABSTRACT FROM AUTHOR]

Published
2019
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18. Mitraclip therapy in patients with functional mitral regurgitation and missing leaflet coaptation: is it still an exclusion criterion?

Author

Adamo, Marianna, primary, Chiari, Ermanna, additional, Curello, Salvatore, additional, Maiandi, Cristian, additional, Chizzola, Giuliano, additional, Fiorina, Claudia, additional, Frontini, Mario, additional, Cuminetti, Giovanni, additional, Pezzotti, Elena, additional, Rovetta, Riccardo, additional, Lombardi, Carlo Mario, additional, Manzato, Aldo, additional, Metra, Marco, additional, and Ettori, Federica, additional

Published
2016
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23. Role of different vascular approaches on transcatheter aortic valve implantation outcome

Author

Adamo, Marianna, primary, Fiorina, Claudia, additional, Curello, Salvatore, additional, Maffeo, Diego, additional, Chizzola, Giuliano, additional, Di Matteo, Gerardo, additional, Mastropierro, Rosa, additional, Nardi, Matilde, additional, Cervi, Edoardo, additional, De Cicco, Giuseppe, additional, Chiari, Ermanna, additional, Curnis, Antonio, additional, Bonardelli, Stefano, additional, Coletti, Giuseppe, additional, Manzato, Aldo, additional, Metra, Marco, additional, and Ettori, Federica, additional

Published
2015
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27. TCT-776 Safety of Axillary and TransAortic Approaches for Transcatheter Aortic Valve Replacement in patients older than 85 years old: Results from Italian CoreValve Registry

Author

Fiorina, Claudia, primary, De Carlo, Marco, additional, De Marco, Federico, additional, Tamburino, Corrado, additional, Ussia, Gian Paolo, additional, Testa, Luca, additional, Bedogni, Francesco, additional, Colombo, Antonio, additional, Chiari, Ermanna, additional, Lipartiti, Felicia, additional, Petronio, Anna Sonia, additional, maffeo, Diego, additional, and Ettori, Federica, additional

Published
2013
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29. A pinball game in the left atrium

Author

Raddino, Riccardo, primary, Caretta, Giorgio, additional, Gorga, Elio, additional, Della Pina, Paolo, additional, Rambaldini, Manfredo, additional, Chiari, Ermanna, additional, and Dei Cas, Livio, additional

Published
2012
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37. The role of plasma biomarkers in acute heart failure. Serial changes and independent prognostic value of NT-proBNP and cardiac troponin-T

Author

Metra, Marco, primary, Nodari, Savina, additional, Parrinello, Giovanni, additional, Specchia, Claudia, additional, Brentana, Loretta, additional, Rocca, Patrizia, additional, Fracassi, Francesco, additional, Bordonali, Tania, additional, Milani, Patrizia, additional, Danesi, Rossella, additional, Verzura, Giulia, additional, Chiari, Ermanna, additional, and Cas, Livio Dei, additional

Published
2007
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39. Results of minimally invasive, video-assisted mitral valve repair in advanced Barlow's disease with bileaflet prolapse†.

Author

Muneretto, Claudio, Bisleri, Gianluigi, Bagozzi, Lorenzo, Repossini, Alberto, Berlinghieri, Nicola, and Chiari, Ermanna

Subjects
INFANTILE scurvy, MITRAL valve surgery, MITRAL valve prolapse, MINIMALLY invasive procedures, THORACIC surgery, TREATMENT of endocarditis, POLYTEF
Abstract

OBJECTIVES Minimally invasive mitral valve (MV) surgery has recently gained popularity as the standard approach for MV repair, albeit there could be potential concerns about the feasibility of complex repair in the presence of extreme Barlow's disease via a minimally invasive route. METHODS Fifty consecutive patients with advanced Barlow's disease and bileaflet prolapse underwent minimally invasive, video-assisted MV repair via a 5 cm right antero-lateral thoracotomy with peripheral cannulation and external aortic clamping. Mean age, left ventricular ejection fraction and New York Heart Association class were 53 ± 11 years, 62 ± 7% and 3.1 ± 0.8, respectively. Logistic EuroSCORE (mean) was 3.1. Either Custodiol (36 patients; 72%) or crystalloid (14 patients; 28%) cardioplegia were utilized. Complete rings (CE Classic or Physio) were implanted. Chordal reimplantation was carried out by means of polytetrafluoroethylene (PTFE) chordae. RESULTS All procedures were successfully performed with null/mild residual mitral regurgitation (MR) intraoperatively. A repair strategy of posterior leaflet resection and PTFE chordae implant (for anterior leaflet) or no-resect approach (only PTFE chordae on both leaflets) was performed in 62% (31 patients) and 38% (19 patients) of cases, respectively. Mean aortic cross-clamp and cardiopulmonary bypass times were 98 ± 23 and 131 ± 41 min, respectively. Hospital mortality was 0%. At a median follow-up of 761 days, 2 patients (4%) required reoperation (infective endocarditis: 1 patient; partial ring detachment: 1 patient) and valve rerepair was achieved in both. All patients are alive with a freedom from ≥2+ degree of MR of 100% at the latest echocardiographic evaluation. CONCLUSIONS Minimally invasive approach for complex MV repair is feasible and safe and provided excellent early and mid-term results. [ABSTRACT FROM PUBLISHER]

Published
2015
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43. Dynamic mild subaortic left ventricular obstruction caused by an accessory mitral valve attached to the anterior mitral valve in a young pregnant woman.

Author

D'Aloia, Antonio, Vizzardi, Enrico, Chiari, Ermanna, Fracassi, Francesco, Zanini, Gregoriana, Faggiano, Pompilio, and Cas, Livio Dei

Abstract

Accessory mitral valve tissue is an extremely rare congenital cardiac anomaly of embryologic development of the endocardial cushion. This anomaly is often associated with left ventricular outflow tract obstruction (LVOTO). A 26-year-old pregnant female was referred to our Department of Cardiology with exertional shortness of breath and tachycardia. Transthoracic and transesophageal echocardiography revealed a flexible circular (1.3 × 1.4 cm), mobile structure attached to the ventricular side of anterior mitral valve leaflet, with chordal attachments structure from anterior papillary muscle. This picture is compatible with a parachute-like accessory mitral valve tissue. We performed an echocardiographic exercise test that shows a systolic flow turbulence starting immediately proximal to this structure, resulting in a small increase in left ventricular outflow tract (LVOT) gradient (30 mmHg). Therefore we started low dose of beta-blocker therapy in order to decrease heart frequency and reduce the future risk of a worsening of an LVOT dynamic obstruction. [ABSTRACT FROM PUBLISHER]

Published
2008
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