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Abstract Accurately predicting rock tensile strength under varying strain rates is crucial for tunnel construction, as rock often fails in tension. This study examines the effect of rock mesostructure on tensile strength using a breakable grain-based model (GBM) implemented within the UDEC software. The Brazilian disk model was established to simulate the quasi-static and dynamic tensile behaviors of rocks under varying mineral average grain sizes, grain size distributions, and grain roundness, respectively. Simulation outcomes indicate that mesostructure significantly influences rock tensile strength. The breakable GBM effectively captures the tensile failure process under high strain rates, revealing the role of grain structure heterogeneity in strain rate effects. Additionally, the study evaluates the applicability of different dynamic increase factor (DIF) models, confirming the effectiveness of the normalized DIF model for predicting the dynamic tensile strength of granite. These findings underscore the importance of considering rock mesostructure for accurate prediction and enhancement of rock performance under dynamic loading conditions.

Abstract Mammary epithelial cells, the only milk-producing cell type in the mammary gland, undergo dynamic proliferation and differentiation during pregnancy, culminating in lactation postpartum. The East FriEsian sheep ranks among the world’s most prolific dairy breeds, while the Sewa sheep, a unique dual-purpose breed autochthonous to the Qinghai-Tibet Plateau, exhibits significantly lower milk production. Employing tissue culture methods, we successfully established mammary epithelial cell lines from both breeds. Morphological assessment of mammary epithelial cells and immunofluorescence identification of Cytokeratin 7 and Cytokeratin 8 confirmed the epithelial identity of the isolated cells. Subsequent RNA-seq analysis of these in vitro epithelial cell lines revealed 1813 differentially expressed genes (DEGs). Among these, 1108 were significantly up-regulated and 705 were down-regulated in Sewa epithelial sheep cells compared to East FriEsian epithelial cells. KEGG enrichment analysis identified cellular processes, environmental information processing, human diseases, metabolism, and organismal systems as the primary functional categories associated with DEGs. Gene ontology (GO) terms annotation, categorized into molecular function, biological processes, and cellular component, yielded “binding and catalytic activity,” “molecular function regulator activity,” and “cellular process,” “biological regulation,” and “regulation of biological process” as the top three terms within each domain, respectively. Clusters of Orthologous Groups of proteins (KOG) classification further revealed that “signal transduction mechanisms” accounted for the largest proportion of DEGs among all KOG categories. Finally, based on these analyses, ATF3 and MPP7 were identified as promising candidate genes for regulating lactation.

Glioblastoma (GBM) is the central nervous system tumor with the most aggressive behavior, and no definitive therapy has yet been found. The tumor microenvironment of GBM is immunosuppressive and is considered a ‘cold tumor’ with low lymphocytic infiltration, but is characterized by a high proportion of glioma-associated macrophages/microglia (GAMs). GAMs promote tumor growth and also affect treatment resistance in GBM. In this review, we describe the origin and classification of GAMs in humans and describe the mechanisms of their activation and the cell-cell interactions between tumor cells and GAMs. We also describe the history of GAM detection methods, especially immunohistochemistry, and discusses the merits and limitations of these techniques. In addition, we summarized chemotactic factors for GAMs and the therapies targeting these factors. Recent single-cell RNA analysis and spatial analysis add new insights to our previous knowledge of GAMs. Based on these studies, GBM therapies targeting GAMs are expected to be further developed.

To explore the interaction between holes and fractures in defective white sandstone, uniaxial compression tests were conducted on samples with varying horizontal distances between holes and fractures. The technique known as Digital Image Correlation (DIC) was employed to analyze the deformation patterns, while CT scanning technology was implemented to elucidate the interior crack propagation features. Discrete Element Method (DEM) simulations were performed to investigate the micro-scale fracture evolution. The findings demonstrate that load-bearing capacity and deformation resistance decreased as the horizontal hole-fracture distance increased. The failure mode transitioned from a mixed tensile-shear failure to a more rapid tensile failure. Tensile wing fractures caused by tensile failure reinforced the merging of rock bridges. Furthermore, the trajectories of fracture propagated from the outside to the inside of the rocks progressively simplify, resulting in accelerated instability and collapse. DEM simulations indicate that the augmentation of horizontal distance between holes and fractures influenced the displacement field and the orientation of micro-fractures inside the samples. The formation of micro-fractures progressively adhered to a “clusteringexpansion-coalescence” sequence along the paths of the hole-fracture structures. The maximum strength of the samples declined in a three-phase pattern: gradual decline, steep decline, and gradual decline. These findings provide valuable insights for engineering applications, such as tunnel excavation and mining operations.

With the goal of examining the micromechanics damage characteristics of freeze-thaw red sandstone under the influence of cyclic loads, a model of freeze-thaw cyclic rock particles is developed based on Discrete Element Method numerical simulation in order to investigate and study the micromechanics response mechanism of rocks under the coupling effect of freeze-thaw and cyclic loads. The findings demonstrate that lower rock elastic modulus and higher irreversible strain are driven by longer loading/unloading durations and more frequent freeze-thaw cycles. Its bearing capacity and resistance to deformation are diminished by the damage brought on by freeze-thaw; Rock anisotropy and the spatial organisation of microcracks are significantly altered by different loading techniques; In freeze-thaw rocks, the frequency and intensity of acoustic emission breaking follow the law of normal distribution. Under cyclic stress, samples exposed to several freeze-thaw cycles exhibit an escalation in large-scale fractures, accompanied by a concentrated spatial distribution of acoustic emission events. Three phases may be distinguished in the energy evolution of red sandstone: the initial, accumulation, and release phases. The energy storage capacity is compromised by freeze-thaw degradation, resulting in an elevated conversion rate of dissipative energy and rendering the energy conversion mechanism more unstable. The previously described study results possess considerable relevance for rock engineering construction and catastrophe mitigation in cold climates.

ABSTRACT Improving livestock growth and raising the quality of livestock products have attracted much attention owing to the market’s growing need for livestock products. Bupleuri Radix branches powder (BR) has a variety of health characteristics, but its effects on ruminant growth and animal product quality are still uncertain. This study explored the effects of BR on growth performance, health status, gut microbiota, and muscle lipid metabolism of Shaanxi fine-wool sheep (SFS), and examined the interaction between gut microbiota and lipid metabolism through correlation analysis. The results indicated that BR can regulate the immune function, intestinal VFAs, and enzyme activity of FSF by improving the gut microbiota, thereby affecting its muscle lipid metabolism. The lipid metabolite TG showed a strong positive correlation with the gut microbes Bacteroides and Fibrobacter, while Phosphatidylethanolamine and Phosphatidyl serine (PE and PS) showed a significant negative correlation with Fibrobacter. The above results indicate that gut microbiota and lipid metabolites interact with each other. BR has the effects of promoting SFS growth, improving body health, and improving meat quality. These findings offer new insights into improve animal growth performance and livestock product quality in modern farming.IMPORTANCEEnhancing livestock growth performance and improving meat quality are important guidelines for the development of the current animal husbandry industry; thus, we explored a comprehensive study of Bupleuri Radix (BR) on growth performance, gut microbiology, and muscle lipid metabolism in Shaanxi fine-wool sheep (SFS). Our research has found that BR could improve the growth performance of SFS and meat quality by affecting gut microbes. This study provides new solutions to improve the economic efficiency of animal husbandry.

Abstract Triboelectric nanogenerator (TENG) operates on the principle of utilizing contact electrification and electrostatic induction. However, visualization and standardized quantification of surface charges for triboelectric materials remain challenging. Here, we report a surface charge visualization and standardized quantification method using electrostatic surface potential measured by Kevin probe and the iterative regularization strategy. Moreover, a tuning strategy on surface charge is demonstrated based on the corona discharge with a three-electrode design. The long-term stability and dissipation mechanisms of the injected negative or positive charges demonstrate high dependence on deep carrier traps in triboelectric materials. Typically, we achieved a 70-fold enhancement on the output voltage (~135.7 V) for the identical polytetrafluoroethylene (PTFE) based TENG (neg-PTFE/PTFE or posi-PTFE/PTFE triboelectric pair) with stable surface charge density (5% decay after 140 days). The charged PTFE was demonstrated as a robot e-skins for non-contact perception of object geometrics. This work provides valuable tools for surface charge visualization and quantification, giving a new strategy for a deeper understanding of contact electrification.

Using renewable steam-exploded poplar (SEP) as carbon source, nickel metal doped carbon hybrid materials were designed to synthesize catalysts (Ni/SEP) with certain oxygen evolution reaction (OER) properties and were compared with nickel catalysts supported on metal organic framework structure (ZIF67-Ni). The roles of SEP support in Ni-based catalyst were considered. Scanning electron microscope (SEM) images confirmed that the fiber could better hinder the aggregation of metal particles. Fourier transform infrared spectroscopy (FT-IR) indicated the presence of surface OH groups after the reduction process. X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) analyses confirmed the major form of metallic Ni in the resulting Ni catalysts. Carbon materials as carriers, the synergetic effect of Ni-doped, and carbon carrier played an important role in facilitating the kinetics of OER, which was similar to the carrier of metal-organic frame material. Notably, the Ni/SEP (11.3 mF/cm-2) and ZIF67-Ni (37.2 mF/cm-2) with better OER performance exhibited a smaller double layer capacitances (Cdl), suggesting the intrinsic OER catalytic activity of the Ni/SEP and ZIF67-Ni were much higher in comparison to the ZIF67-Ni/SEP. Moreover, the inferior performance of Ni/SEP further indicated that the synergistic effect between carbon and Ni/NiO contributes to the enhanced OER activity.

Abstract Background Photodynamic therapy (PDT) is an antitumor therapy and has traditionally been regarded as a localized therapy in itself. However, recent reports have shown that it not only exerts a direct cytotoxic effect on cancer cells but also enhances body's tumor immunity. We hypothesized that the immunological response induced by PDT could potentially enhance the efficacy of programmed death‐1 (PD‐1) / programmed death‐ligand 1 (PD‐L1) blockade. Methods The cytotoxic effects of PDT on colon 26 cells were investigated in vitro using the WST assay. We investigated whether the antitumor effect of anti‐PD‐1 antibodies could be amplified by the addition of PDT. We performed combination therapy by randomly allocating tumor‐bearing mice to four treatment groups: control, anti‐PD‐1 antibodies, PDT, and a combination of anti‐PD‐1 antibodies and PDT. To analyze the tumor microenvironment after treatment, the tumors were resected and pathologically evaluated. Results The viability rate of colon 26 cells decreased proportionally with the laser dose. In vivo experiments for combined PDT and anti‐PD‐1 antibody treatment, combination therapy showed an enhanced antitumor effect compared with the control. Immunohistochemical findings of the tumor microenvironment 10 days after PDT indicated that the number of CD8+ cells, the area of Iba‐1+ cells and the area expressing PD‐L1 were significantly higher in tumors treated with combination therapy than in tumors treated with anti‐PD‐1 antibody alone, PDT alone, or the control. Conclusions PDT increased immune cell infiltration into the tumor microenvironment. The immunological response induced by PDT may enhance the efficacy of PD‐1/PD‐L1 blockade.

Abstract The surface charge accumulation on the basin insulator is a particular problem in high‐voltage direct current (HVDC) gas insulated switchgears (GIS) and gas insulated transmission lines (GIL), which restricts the development and application of extra/ultra high‐voltage (EHV/UHV) technology. The surface charge distribution and anti‐flashover performance are closely related to the insulator shape. To obtain the optimal basin insulator, a shape optimisation model based on artificial bee colony algorithm was established, and the minimisation objective functions based on capacitive (initial) electric field distribution and resistive (steady‐state) electric field distribution were respectively constructed. The optimisation results of the two objective functions were calculated, and the electric field and charge distribution on the surface of the insulator before and after optimisation were evaluated and compared using the simulation model. The results indicated that the optimisation based on the capacitive electric field can significantly inhibit the surface charge accumulation, and the optimised insulator can significantly reduce the surface normal electric field and make the distribution of the tangential electric field more uniform, and the maximum tangential electric field can be reduced by 10%; the optimisation based on resistive electric field can achieve similar results, but requires more computational resources. Based on the results, the ‘anti‐charge’ basin insulator structure suitable for the DC field was given.

Cyclic annulation involving diaryliodonium salts is an efficient tool for the construction of two or more chemical bonds in a one-pot process. Ortho-functionalized diaryliodonium salts have showcased distinct reactivity in the exploration of benzocyclization or arylocyclization. With this strategy of ortho-ester-substituted diaryliodonium salts, herein, we utilized a copper catalyst to activate the C–I bond of diaryliodonium salts in the generation of aryl radicals, thus resulting in an annulation reaction with naphthols and substituted phenols. This approach yielded a diverse array of 3,4-benzocoumarin derivatives bearing various substituents.

As a promising anode material for magnesium ion rechargeable batteries, magnesium metavanadate (MgV2O6) has attracted considerable research interest in recent years. A MgV2O6 sample was synthesized via a facile solid-state reaction by multistep-firing stoichiometric mixtures of MgO and V2O5 powder under an air atmosphere. The solid-state phase transition from α-MgV2O6 to β-MgV2O6 occurred at 841 K and the enthalpy change was 4.37 ± 0.04 kJ/mol. The endothermic effect at 1014 K and the enthalpy change was 26.54 ± 0.26 kJ/mol, which is related to the incongruent melting of β-MgV2O6. In situ XRD was performed to investigate phase transition of the as-prepared MgV2O6 at high temperatures. The cell parameters obtained by Rietveld refinement indicated that it crystallizes in a monoclinic system with the C2/m space group, and the lattice parameters of a = 9.280 Å, b = 3.501 Å, c = 6.731 Å, β = 111.76°. The solid-state phase transition from α-MgV2O6 to β-MgV2O6 was further studied by thermal kinetics, indicating that this process is controlled first by a fibril-like mechanism and then by a spherulitic-type mechanism with an increasing heating rate. Additionally, the enthalpy change of MgV2O6 at high temperatures was measured utilizing the drop calorimetry, heat capacity was calculated and given as: Cp = 208.3 + 0.03583T-4809000T−2 (298 – 923 K) (J mol−1 K−1), the high-temperature heat capacity can be used to calculate Gibbs free energy of MgV2O6 at high temperatures.

Abstract The interactions between the rumen microbiota and the host are crucial for the digestive and absorptive processes of ruminants, and they are heavily influenced by the climatic conditions of their habitat. Owing to the harsh conditions of the high-altitude habitat, little is known about how ruminants regulate the host transcriptome and the composition of their rumen microbiota. Using the model species of goats, we examined the variations in the rumen microbiota, transcriptome regulation, and climate of the environment between high altitude (Lhasa, Xizang; 3650 m) and low altitude (Chengdu, Sichuan, China; 500 m) goats. The results of 16 S rRNA sequencing revealed variations in the abundance, diversity, and composition of rumen microbiota. Papillibacter, Quinella, and Saccharofermentans were chosen as potential microbes for the adaptation of Xizang goats to the harsh climate of the plateau by the Spearman correlation study of climate and microbiota. Based on rumen transcriptome sequencing analysis, 244 genes were found to be differentially expressed between Xizang goats and low-altitude goats, with 127 genes showing up-regulation and 117 genes showing down-regulation. SLC26A9, GPX3, ARRDC4, and COX1 were identified as potential candidates for plateau adaptation in Xizang goats. Moreover, the metabolism of fatty acids, arachidonic acids, pathway involving cytokines and their receptors could be essential for adaptation to plateau hypoxia and cold endurance. The expression of GPX3, a gene linked to plateau acclimatization in Xizang goats, was linked to the abundance of Anaerovibrio, and the expression of SLC26A9 was linked to the quantity of Selenomonas, according to ruminal microbiota and host Spearman correlation analysis. Our findings imply that in order to adapt harsh plateau conditions, Xizang goats have evolved to maximize digestion and absorption as well as to have a rumen microbiota suitable for the composition of their diet.

Abstract Background Solid nodules (SN) had more aggressive features and a poorer prognosis than part-solid nodules (PSN). This study aimed to evaluate the specific impacts of nodule radiological appearance (SN vs. PSN) on lymph node metastasis and prognosis based on solid size in cT1 non-small cell lung cancer (NSCLC). Methods Patients with cT1 NSCLC who underwent anatomical resection between 2010 and 2019 were retrospectively screened. Univariable and multivariable logistic regression analyses were adopted to evaluate the associations between nodule radiological appearance and lymph node metastasis. The log-rank test and Cox regression analyses were applied for prognostic evaluation. The cumulative recurrence risk was evaluated by the competing risk model. Results There were 958 and 665 NSCLC patients with PSN and SN. Compared to the PSN group, the SN arm had a higher overall lymph node metastasis rate (21.7% vs. 2.7%, P

The stability analysis of spherical hybrid sliding bearings includes exploring its dynamic characteristics and critical speed, its stiffness and damping coefficient have an important impact on the stability of the bearing-rotor system, and the study of critical speed can effectively avoid whirl instability in the bearing-rotor system. The boundary slip conditions are considered to analyze the stability of spherical hybrid sliding bearings. Taking the flow of the small hole restrictor into the oilcavity equal to the flow out of the oil sealing edge as the boundary condition, the Reynolds equation in the boundary slip state is solved to obtain the oil cavity pressure and the oil sealing edge pressure. For the transient Reynolds equation in the boundary slipstate, the equation uses the small perturbation method to derive the partial differential equation of the perturbation pressure, and combines the finite difference method and the relaxation iterative method to solve the equation to obtain the stiffness and damping coefficient of the ball bearing under the state of boundary slip, and then establish the shafting trajectory equation to solve the instability speed. The influence of slip coefficient, oil supply pressure, rotor speed on the dynamic characteristics of the bearingand the variation law of the instability speed on the slip coefficient are discussed. The results show that the increase of the slipcoefficient will lead to the decrease of the four stiffness coefficients and the cross damping coefficients, and the increase of thedirect dampings. The increase of the oil supply pressure will lead to the increase of the eight dynamic characteristic coefficients, and the increase of the rotational speed will lead to the increase of the stiffness and the decrease of the dampings, and the occurrence of slip effect does not affect the above rules. The instability speed decreases with the increase of slip coefficient, so the system stability decreases.

Abstract The prognosis of osteosarcoma (OS) has remained stagnant over the past two decades, requiring the exploration of new therapeutic targets. Cytokines, arising from tumor-associated macrophages (TAMs), a major component of the tumor microenvironment (TME), have garnered attention owing to their impact on tumor growth, invasion, metastasis, and resistance to chemotherapy. Nonetheless, the precise functional role of TAMs in OS progression requires further investigation. In this study, we investigated the interaction between OS and TAMs, as well as the contribution of TAM-produced cytokines to OS advancement. TAMs were observed to be more prevalent in lung metastases compared with that in primary tumors, suggesting their potential support for OS progression. To simulate the TME, OS and TAMs were co-cultured, and the cytokines resulting from this co-culture could stimulate OS proliferation, migration, and invasion. A detailed investigation of cytokines in the co-culture conditioned medium (CM) revealed a substantial increase in IL-8, establishing it as a pivotal cytokine in the process of enhancing OS proliferation, migration, and invasion through the focal adhesion kinase (FAK) pathway. In an in vivo model, co-culture CM promoted OS proliferation and lung metastasis, effects that were mitigated by anti-IL-8 antibodies. Collectively, IL-8, generated within the TME formed by OS and TAMs, accelerates OS proliferation and metastasis via the FAK pathway, thereby positioning IL-8 as a potential novel therapeutic target in OS.

We herein present a case of a ruptured giant omphalocele with congenital short small intestine. Vacuum-sealing drainage and carboxymethylcellulose silver dressing promoted wound healing after repair, avoided abdominal compartment syndrome, and reduced the risks of multiple procedures. We review the perioperative management of omphaloceles in congenital short small intestines.

Objective To explore diagnosis points of carotid artery ultrosound in patients of internal carotid artery (ICA) absence and other imaging features. Methods and Results Total 14 patients diagnosed with ICA absence in Tianjin Huanhu Hospital from January 2014 to May 2023 were retrospectively analyzed. Ten patients were male and 4 patients were female. The age of patients ranged from 13 to 79 years. Imaging exam: the CTA and (or) MRA of all patients showed absence of carotid canal, no development of the entire ICA, combined with intracranial vascular abnormalities. Eight of 14 patients had left ICA absence, 5 had right ICA absence, and one had bilateral ICA absence. According to collateral compensation LIE typing, 6 cases were type A, 2 cases were similar to type A with the existent of the A1 segment of ipsilateral anterior cerebral artery (ACA), 2 cases were type B, one case was type C, and one case was similar to type D as ipsilateral ACA was supplied by opposite through the anterior communicating artery, the ipsilateral middle cerebral artery (MCA) was supplied from the clinoid process of the contralateral ICA. Carotid artery ultrasound: all the 14 patients showed thin vessels in the extracranial segment of the common carotid artery (CCA) without bifurcation, which directly continued into external carotid artery (ECA), indicating the absence of one or both ICA absence; carotid artery bifurcation was not detected in multi⁃angle scanning of both 2D scan and color Doppler flow imaging, and the CCA directly continued into a single artery ECA with multiple branches; a "sawtooth" spectrum of the ipsilateral ECA was observed when tap the superficial temporal artery, which indicated that the artery was ECA; blood flow spectrum of the ipsilateral CCA was consistent with ipsilateral ECA. Conclusions Carotid artery ultrasound has high accuracy in the initial diagnosis of ICA absence. It is suitable for clinical application.

ObjectiveTo analyze the community structure and dynamics of parasitic fleas on the body surface of host animals and nested fleas in different seasons in the natural foci of wild rat plague in Yulong County，Yunnan Province， to explore the relationship between seasonal fluctuation of fleas and the prevalence of plague among animals， so as to provide evidence for plague prevention and control in the natural foci.MethodsNanxi Village， Huangshan Town， the core area of plague epidemic in Yulong County， was selected as the monitoring sample area in December 2019 （winter）， August 2020（summer）， October 2020（autumn） and March 2021（spring）. Host animals were captured by rattrap at night and rat nests were excavated for collecting parasitic fleas on host animals and rat nest fleas in different seasons. Excel 2010 and SPSS 26.0 software were used to analyze the data， and Chi square test was used to compare the rate. Community ecological indicators were used to analyze the community structure and species diversity of the host animals and their parasitic fleas.ResultsA total of 355 vector fleas were captured， belonging to 7 species of 5 genera in 2 families. 441 small animals were captured and 138 rat body fleas were detected with the flea infection rate of 14.51% and the flea index 0.31. 96 effective rat holes were excavated and 217 fleas were detected with the flea infection rate of 35.42% and the flea index 2.26. Among the four seasons， the flea infection rates of rat body and rat nests were higher in summer and winter， showing a significant difference in general （χ2=15.851， P

Background: The posterior procedure utilizing growth-friendly techniques is the golden standard for patients with early-onset scoliosis combined with thoracic insufficiency syndrome (EOS + TIS). Pulmonary hypoplasia is the main cause of dying prematurely in the EOS + TIS. This study assessed the therapeutic impact of a novel growth-friendly system on the pulmonary development of piglet's EOS + TIS model. Methods: The animal procedure period lasts 12 weeks, of which the construction of the EOS + TIS was performed at 0–8 weeks, and implantation of a novel growth-friendly system was applied at 8–12 weeks. During the animal procedure, X-rays and CT were performed to observe scoliosis, thorax, and lungs. After 12 weeks, pathological changes in lung tissue were assessed using HE and IHC staining. RNA-seq characterized novel growth-friendly system-associated differentially expressed genes (DEGs) and validated using RT-qPCR, western blotting, and IHC. Results: Implantation of the novel growth-friendly system increased body weight, body length, and total lung volume, as well as decreased the coronal and sagittal Cobb angles for the EOS + TIS model. It also ameliorated EOS + TIS-induced thickening of the alveolar wall, increased alveolar spaces, and decreased alveolar number and diameter. In lung tissue, a total of 790 novel growth-friendly system-associated DEGs were identified, and they were mainly involved in the regulation of immune, inflammatory, calcium transport, and vascular development. Among these DEGs, BDKRB1, THBS1, DUSP1, IDO1, and SPINK5 were hub genes, and their differential expression was consistent with RNA-seq results in lung tissues. Conclusion: The novel growth-friendly system has mitigated scoliosis and pulmonary hypoplasia in the EOS + TIS model. We further elucidate the molecular mechanisms underlying the amelioration of pulmonary hypoplasia.

Abstract The relationship between strain and elastic energy is simplified by introducing a stress state parameter based on the generalised Hooke’s law. It is assumed that the micro-element strengths satisfy the Weibull distribution and a new model for the non-linear evolution of energy is developed by introducing the concept of rock micro-element strengths. A sensitivity analysis of the model parameters is carried out on this basis. The results show that the model agrees well with the experimental data. The model is close to the deformation and damage laws of the rock and is able to reflect the relationship between the elastic energy and strain of the rock. By comparing with other model curves, the model of this paper is more suitable for the experimental curve. They show that the improved model could better describe the stress–strain relationship of rock. Finally, according to the analysis of the influence of the distribution parameter on the variation pattern of the elastic energy of the rock, the magnitude of the distribution parameter can directly reflect the peak energy of the rock.

Intracerebral hemorrhage (ICH) is a critical condition characterized by a high prevalence, substantial mortality rates, and unpredictable clinical outcomes, which results in a serious threat to human health. Improving the timeliness and accuracy of prognosis assessment is crucial to minimizing mortality and long-term disability associated with ICH. Due to the complexity of ICH, the diagnosis of ICH in clinical practice heavily relies on the professional expertise and clinical experience of physicians. Traditional prognostic methods largely depend on the specialized knowledge and subjective judgment of healthcare professionals. Meanwhile, existing artificial intelligence (AI) methodologies, which predominantly utilize features derived from computed tomography (CT) scans, fall short of capturing the multifaceted nature of ICH. Although existing methods are capable of integrating clinical information and CT images for prognosis, the effectiveness of this fusion process still requires improvement. To surmount these limitations, the present study introduces a novel AI framework, termed the ICH Network (ICH-Net), which employs a joint-attention cross-modal network to synergize clinical textual data with CT imaging features. The architecture of ICH-Net consists of three integral components: the Feature Extraction Module, which processes and abstracts salient characteristics from the clinical and imaging data, the Feature Fusion Module, which amalgamates the diverse data streams, and the Classification Module, which interprets the fused features to deliver prognostic predictions. Our evaluation, conducted through a rigorous five-fold cross-validation process, demonstrates that ICH-Net achieves a commendable accuracy of up to 87.77%, outperforming other state-of-the-art methods detailed within our research. This evidence underscores the potential of ICH-Net as a formidable tool in prognosticating ICH, promising a significant advancement in clinical decision-making and patient care.

To investigate the mechanical properties and energy evolution laws of rocks under true triaxial unloading conditions, a study was conducted using a true triaxial rock testing system on three different types of rocks: coal, sandy mudstone, and siltstone. The study examined the mechanical behavior, failure patterns, and fractal dimensions of these rocks under true triaxial unloading conditions. The tests revealed significant variations in stress–strain curves and failure patterns among the different rock types. Observation indicated that rocks with lower peak strength exhibited higher fractal dimensions and increased fragmentation upon failure. Subsequently, based on the experimental data of siltstone, the impact of the unloading rate and particle size distribution on the energy evolution under true triaxial single-sided unloading paths was further investigated using the three-dimensional particle flow software PFC3D 6.0, revealing the micro-mechanisms of rock energy evolution. The study revealed that when the initial stress unloading level was low, the total energy and strain energy at the peak strength exhibited a strong linear relationship with the unloading rate. Before the stress peak, the dissipative energy was mainly composed of frictional energy. After the stress peak, the dissipative energy consisted of frictional energy, damping energy, and kinetic energy. The heterogeneity of rock significantly affected the distribution of dissipative energy, with an increase in rock heterogeneity leading to a decrease in frictional energy and an increase in kinetic energy.

Abstract Objectives C‐reactive protein (CRP) is a well‐known acute‐phase protein that increases remarkably under various inflammatory conditions and is elevated in patients with malignant tumors. In this study, we investigated the influence of CRP on the tumor microenvironment in clear cell renal cell carcinoma (ccRCC). Methods This study explored CRP's role in ccRCC by co‐culturing human macrophages with ccRCC cells and employing antibody blocking, RNA sequencing and in vitro experiments for functional insights. We also analysed The Cancer Genome Atlas Program (TCGA) data to link CD64 expression with ccRCC prognosis and used immunohistochemistry to associate CD64+ macrophages with tumor severity and systemic CRP levels. Results A co‐culture study using human macrophages and RCC cell lines showed that CRP‐stimulated macrophages secrete IL‐6, which induces RCC proliferation via STAT3 activation. CRP‐induced protumor activation of macrophages was suppressed by CD64 blocking antibodies. Furthermore, CRP elevates PD‐L1 expression in macrophages via the CD64‐STAT1 signalling pathway. Statistical analysis of TCGA data indicated that increased CD64 expression was associated with a worse clinical course in ccRCC. Immunohistochemical analysis of pathological specimens revealed that high CD64 expression in tumor‐associated macrophages (TAMs), and a high density of CD64+ TAMs, was linked to high nuclear grade and stage. High CD64 expression was also correlated with increased serum CRP levels. Conclusions The CRP‐CD64 signal was linked to the protumor activation of TAMs and could be a promising target for anticancer immunotherapy in ccRCC.

In order to study the mode I crack propagation mechanism of coal gangue concrete with different contents, the digital image correlation (DIC) method was used to carry out the three-point bending fracture tests on coal gangue concrete with different contents. The results show that the process of the mode I crack propagation of coal gangue concrete with different contents can be divided into three stages as follows: the elastic stage before crack initiation, extended viscoelastic stage, and extended fracture stage. The amount of coal gangue has a significant impact on the crack propagation path. The more the amount of coal gangue, the more the crack penetrates through the coal gangue coarse aggregate, the smaller the bending degree of the failure path, and the faster the crack propagation to the penetration speed. The crack initiation load, ultimate load, external force work, gravity work, and fracture energy all decrease with the increase of the coal gangue content. The data obtained by the DIC method and displacement extensometer are in good agreement, which proves that the DIC method is feasible. Based on the DIC method, before reaching the horizontal displacement on both sides of the crack tip, the horizontal displacement of the horizontal pixel is very small and there is a jump increase after the ultimate load. There are obvious inflection points on the left and right, and the horizontal displacement remains unchanged after the inflection point. After the horizontal displacement field of crack propagation reaches the limit load, there is an obvious limit; the limit gradually extends upward, and the corresponding crack tip strain field is also gradually enhanced. The more the coal gangue is added, the smaller the corresponding horizontal displacement and strain field is at the same limit load moment. The shape of the crack generation area of coal gangue concrete takes the crack tip as the axis of symmetry and is “gourd shaped.” The more the content of the crack, the larger the crack generation area.

Deep-hole bench blasting is the primary method for aggregate extraction in mines. However, factors such as complex geological conditions and suboptimal blasting parameters often result in uneven rock fragmentation and high fines content. This not only increases the cost and energy consumption of subsequent aggregate processing but also has adverse environmental implications. In this study, based on the Changjiu Shenshan limestone aggregate mining project in China, large-scale blasting experiments were conducted to investigate the influence of rock properties and blasting parameters on the size distribution of post-blast fragments and fines content. The results of the blasting experiments indicate that by controlling the size of the crushing zone and adjusting explosive performance, it is possible to significantly reduce fines content while improving mining efficiency. Recommended values for drilling and blasting parameters have been proposed based on geological conditions to more effectively control the generation of fines. The results highlight the importance of optimizing blasting parameters and charge structure for large-scale mining operations to achieve uniform rock fragmentation and low fines content. By adopting explosive performance adjustment methods based on reasonable control of the crushing zone, improving explosive performance can improve the economic benefits of mining operations, reduce energy consumption, and contribute to environmental protection.

To improve the utilization efficiency of renewable energy and adaptability of composite materials, a new mineral-based composite phase change material (Ag-Mica/CNF/PW) was designed and prepared by chemically modifying natural mica, attaching silver nanoparticles to the mica surface as functionalized support material, and using paraffin wax as the phase change functional medium. As expected, the thermal conductivity of the composite phase change material (CPCMs) increased significantly to 0.9 W/m k, which was 330.1% higher relative to pure paraffin. With the addition of silver-modified mica, the volume resistivity of CPCMs reached 11.9 × 1012 Ω cm. The relative enthalpy efficiency achieved 104.8%, and the photothermal conversion efficiency reached 91.3%, proving that the silver-modified mica-based CPCM was successful and feasible. The heat resistance index of CPCMs was 137.2 °C, and the enthalpy loss rate after 50 cycles was only 0.7 %, indicating that CPCMs have excellent thermal stability. The designed CPCMs are a promising candidate for developing thermal storage and building thermal management, electrical insulation and solar energy conversion.

Abstract Different stress creep tests are conducted on the sandstone in this study to better describe the creep properties of rocks under different stress states. A model that describes the rock creep process is established. The various stages of creep can be described by combining the creep properties of the creep elements of the model. A new method for determining creep parameters is proposed by using the special point on the creep curve and the definition of creep deformation. The relationship between the creep parameters, stress, and time is analyzed. An improved creep model that considers the effects of stress state and time on the creep parameters is developed. This model is verified using experimental data and calculation results. Results shows that the improved creep model better describes the creep properties of rocks and provides a new method for determining future model parameters. The shear modulus of elastic model controls the instantaneous deformation. The shear modulus of viscoelastic model governs the limit of viscoelastic deformation. The shear viscoelastic coefficient of viscoelastic model increases with the increase in stress. The coefficient of viscoplastic model controls the viscoplastic creep rate. The coefficient of a nonlinear Newtonian dashpot mainly controls the accelerated creep deformation of rock. The calculation results of the proposed model agree well with the experimental data under the action of different stress levels. This model accurately reflects the creep characteristics of the primary and steady-state creep stages, and overcomes the shortcomings of the traditional Nishihara model in describing accelerated creep.

The oil film temperature of the spherical hybrid sliding bearings would increase due to the friction and shear of the lubricating oil at high speed or super high speed, which leads to the thermal deformation of bearing and rotor. As a result, the deformation seriously affects the rotation accuracy of the spindle, because it is in the same order of magnitude as the oil film thickness. Therefore, the fluid lubrication mathematical model is established by taking the spherical hybrid sliding bearings with orifice throttling mode as the research object, and the Reynolds equation and energy equation of lubricating oil film are derived. The pressure distribution and temperature distribution of oil film of the spherical hybrid sliding bearings are calculated by combining the finite difference method and relaxation iteration method. The influence of working parameters on bearing capacity and oil film temperature rise was investigated. The results show that the oil film shear effect is stronger and the temperature rise increases with the increase of rotating speed and the decrease of oil film thickness. When the speed is 3 000 r/min and the oil film thickness is 28 μm, the maximum temperature rise of the bearing is 18.65 K higher than that of 1 000 r/min. When the speed is 3 000 r/min and the oil film thickness is 20 μm, the maximum temperature rise of the bearing is 27.685 K higher than that of the oil film thickness of 28 μm.

The construction of the future energy structure of China under the 2050 carbon-neutral vision requires compact direct current (DC) gas-insulation equipment as important nodes and solutions to support electric power transmission and distribution of long-distance and large-capacity. This paper reviews China's 10-year progress in DC gas-insulated equipment. Important progresses in basic research and industry perspective are presented, with related scientific issues and technical bottlenecks being discussed. The progress in DC gas-insulated equipment worldwide (Europe, Japan, America) is also reported briefly.

The mesostructure of brittle rocks, such as granite, plays a vital role in determining their mechanical properties and failure mode. Understanding the influence of rock mesostructure on mechanical behavior requires a realistic representation of grain size distribution, grain shape, and average grain size. In this study, we developed a breakable polygonal discrete element model that incorporates mineralogical composition, grain size distributions, and grain shape to simulate the rock mesostructure. Numerical specimens with varying mesostructures were created to represent different grain size, shape, and distribution characteristics. Quasi-static uniaxial compressive loading tests were conducted on these specimens to analyze their peak strength and macroscopic failure modes. The results revealed a strong linear relationship between the quasi-static compressive strength of the rock and mesostructure parameters, including average grain size, grain size coefficient, and grain roundness. Additionally, the simulation results demonstrated that the rock mesostructure significantly influenced the quasi-static compression failure mode. The proposed breakable polygonal discrete element model has the potential to predict the macroscopic behavior of brittle rocks accurately. It provides a reliable method for studying the effect of mesostructure on the quasi-static compressive mechanical behavior of rocks.

Saliva plays a crucial role in shaping the compatibility of piercing–sucking insects with their host plants. Understanding the complex composition of leafhopper saliva is important for developing effective and eco-friendly control strategies for the tea green leafhopper, Empoasca flavescens Fabrecius, a major piercing–sucking pest in Chinese tea plantations. This study explored the saliva proteins of tea green leafhopper adults using a custom collection device, consisting of two layers of Parafilm stretched over a sucrose diet. A total of 152 proteins were identified using liquid chromatography–tandem mass spectrometry (LC-MS/MS) following the filter-aided sample preparation (FASP). These proteins were categorized into six groups based on their functions, including enzymes, transport proteins, regulatory proteins, cell structure proteins, other proteins, and unknown proteins. Bioinformatics analyses predicted 16 secreted proteins, which were successfully cloned and transcriptionally analyzed across various tissues and developmental stages. Genes encoding putative salivary secretory proteins, including Efmucin1, EfOBP1, EfOBP2, EfOBP3, Efmucin2, low-density lipoprotein receptor-related protein (EfLRP), EFVg1, and EFVg2, exhibited high expressions in salivary gland (SG) tissues and feeding-associated expressions at different developmental stages. These findings shed light on the potential elicitors or effectors mediating the leafhopper feeding and defense responses in tea plants, providing insights into the coevolution of tea plants and leafhoppers. The study’s conclusions open avenues for the development of innovative leafhopper control technologies that reduce the reliance on pesticides in the tea industry.

Oxidative stress (OS) in ruminants is closely associated with disease; thus, improving antioxidant capacity is an important strategy for maintaining host health. Bupleuri Radix (BR) could significantly improve host health and stress levels. However, the clear antioxidant mechanism of the function of BR remains unknown. In the current study, LC-MS metabolomics combined with 16S rRNA gene sequencing was employed to explore the effects of BR on rumen microbiota and metabolites in Shanbei Fine-Wool Sheep (SFWS), and Spearman correlation analyses of rumen microbiota, metabolites, and OS were performed to investigate the mechanism of antioxidant function of BR. Our results indicated that as SFWS grows, levels of OS and antioxidant capacity increase dramatically, but providing BR to SFWS enhances antioxidant capacity while decreasing OS. Rumen microbiota and OS are strongly correlated, with total antioxidant capacity (T-AOC) showing a significant negative correlation with Succiniclasticum and a positive correlation with Ruminococcus. Importantly, the Chao1 index was significantly negatively correlated with malondialdehyde (MDA) and positively correlated with superoxide dismutase (SOD) and T-AOC. Two biomarkers connected to the antioxidant effects of BR, 5,6-DHET and LPA (a-25:0/0:0), were screened according to the results of metabolomics and Spearman analysis of rumen contents, and a significant relationship between the concentration of rumen metabolites and OS was found. Five metabolic pathways, including glycerolipid, glutathione, nucleotide, D-amino acid, and inositol phosphate metabolism, may have a role in OS. The integrated results indicate that rumen microbiota and metabolites are strongly related to OS and that BR is responsible for reducing OS and improving antioxidant capacity in post-weaned SFWS. These findings provide new strategies to reduce OS occurring during SFWS growth.

Abstract Ever since immune checkpoint inhibitors have been approved for anti-cancer therapy in several cancers, including triple-negative breast cancer, the significance of programmed death-1 ligand 1 (PD-L1) expression in the tumor immune microenvironment has been a topic of interest. In the present study, we investigated the detailed mechanisms of PD-L1 overexpression on tumor-associated macrophages (TAMs) in breast cancer. In in vitro culture studies using human monocyte-derived macrophages, lymphocytes, and breast cancer cell lines, PD-L1 overexpression on macrophages was induced by the conditioned medium (CM) of activated lymphocytes, but not that of cancer cells. Granulocyte–macrophage colony-stimulating factor (GM-CSF) derived from activated lymphocytes was found to be involved in PD-L1 overexpression, in addition to interferon (IFN)-γ, via STAT3 pathway activation. Macrophages suppressed lymphocyte activation, and this inhibition was impaired by PD-1 blocking. The CM of activated lymphocytes also induced the overexpression of PD-L2, but GM-CSF did not affect PD-L2 expression. In the murine E0771 breast cancer model, anti-GM-CSF therapy did not affect PD-L1 expression on TAMs, and the mechanisms of PD-L1 expression on TAMs might differ between humans and mice. However, not only PD-L1, but also PD-L2 was overexpressed on TAMs in the E0771 tumor model, and their expression levels were significantly lower in the tumors in nude mice than in wild-type mice. Anti-PD-L1 antibody and anti-PD-L2 antibody synergistically inhibited E0771 tumor development. In conclusion, PD-L1 and PD-L2 were overexpressed on TAMs, and they potentially contributed to immunosuppression. The GM-CSF-STAT3 pathway is thought to represent a new mechanism of PD-L1 overexpression on TAMs in human breast cancer microenvironment.

Wild castor grows in the high-altitude tropical desert of the African Plateau, a region known for high ultraviolet radiation, strong light, and extremely dry condition. To investigate the potential genetic basis of adaptation to both highland and tropical deserts, we generated a chromosome-level genome sequence assembly of the wild castor accession WT05, with a genome size of 316 Mb, a scaffold N50 of 31.93 Mb, and a contig N50 of 8.96 Mb, respectively. Compared with cultivated castor and other Euphorbiaceae species, the wild castor exhibits positive selection and gene family expansion for genes involved in DNA repair, photosynthesis, and abiotic stress responses. Genetic variations associated with positive selection were identified in several key genes, such as LIG1, DDB2, and RECG1, involved in nucleotide excision repair. Moreover, a study of genomic diversity among wild and cultivated accessions revealed genomic regions containing selection signatures associated with the adaptation to extreme environments. The identification of the genes and alleles with selection signatures provides insights into the genetic mechanisms underlying the adaptation of wild castor to the high-altitude tropical desert and would facilitate direct improvement of modern castor varieties.

Circular RNAs (circRNAs), as endogenous non-coding RNA with unique closed ring structure, is closely related to animal reproduction, and understanding the expression of circRNA in yak and cattleyak epididymal tissues is of great significance for understanding cattleyak sterility. Based on this, we screened and identified the differentially expressed circRNA in the epididymis of three yaks and two cattleyak. A total of 1,298 circRNAs were identified in the epididymis of yak and cattleyak, of which 137 differentially expressed (DE) circRNAs and the functions of some of them were elucidated in this research, as well as qPCR verification to 6 circRNAs from the 137 DE circRNAs. Gene Ontology (GO) enrichment analysis suggested that DE circRNAs were mainly related to metabolic process, development process, immune system process, reproductive process, reproduction, biological adhesion and growth. COG classification analysis showed that the DE circRNAs derived genes were mainly related to replication, recombination and repair. KEGG pathway analysis suggested that DE circRNAs were mainly involved in RNA degradation. In addition, we also screened Bta-mir-103, which is a circRNA binding miRNA related to sperm activity.

To study the fatigue failure of an intermittent jointed rock mass under repeated stress waves, numerical models of jointed rock masses with different joint angles were created using Autodyne software, and crack propagation behavior was simulated using the Drucker–Prager strength model and cumulative damage failure criteria. In this numerical simulation, the influence of stress wave amplitude and the mode of disturbance on fatigue failure of the rock mass were analyzed. The simulation results showed a significant difference between the failure process of jointed rock masses subjected to repeated stress waves and those exposed to a single stress wave, including crack initiation locations, propagation paths, and rock mass failure patterns. With increasing angles of inclination, the fatigue life of the rock mass first decreased and then increased under repeated stress waves. As the joint inclination angle, β, increased from 20° to 50°, it had a significant influence on the fatigue life of the rock mass, which decreased rapidly with increases in β. The variation in the disturbance form (the change in amplitude of the stress waves from small to large, or from large to small) did not affect the final macro failure pattern of the rock mass; but the extent of damage to the rock mass was affected.

We propose a novel cell structure of spin–orbit torque (SOT) magnetic random-access memory (MRAM), which consists of three transistors and two canted-type x SOT magnetic tunnel junctions (3T2M) with opposite canting angle (+φ/-φ) on a shared heavy-metal, enabling a self-referencing scheme. Owing to the canting-angle-dependent switching polarity, the 3T2M unit keeps switching to complementary states without any complex structure, corroborating an excellent application potential for practical CMOS integration. Moreover, upon tailoring the canting angle and the ratio of field-like over damping-like torque in the free layer, the developed architecture demonstrates efficient and reliable field-free magnetization switching with a significantly improved read sensing margin (230 mV and 160 mV for reading “1” and “0”) and outstanding thermal stability (Δ∼70). The 3T2M cell exhibits 0.25 ns ultra-fast write speed, a 6 × reduced write energy of 35.41 fJ, and 23.65 fJ for “1” and “0” than the state-of-the-art.

In order to reduce the energy consumption of pure electric vehicles and improve the driving range of electric vehicles， a new dual-motor nutating dynamic coupling system is taken as the research object， and a control strategy with the minimum electric power as the target is proposed. Based on the entire control strategy framework， the control strategy is divided into upper， middle， and lower layers. The upper control strategy is the calculation of demand torque. According to the driver's intention， road information， battery information， etc.， the vehicle's demand torque is accurately obtained. The middle control strategy is drive mode division and power distribution. The mode division is based on the vehicle speed as the logical threshold and the minimum electric power as the target to develop a dual-motor speed and torque distribution strategy to achieve dual-motor power system power distribution. The lower-level control strategy is mode switching process control. In order to reduce the power drop of mode switching， in the process of switching from single motor mode to dual motor mode， power reduction processing is adopted. Finally， a simulation model of dual-motor dynamic coupling system is established in Matlab/Simulink， which verifies the reliability of the control strategy.

Abstract Background Liver fibrosis (LF) is a common pathological process characterized by the activation of hepatic stellate cells (HSCs) and accumulation of extracellular matrix. Severe LF causes cirrhosis and even liver failure, a major cause of morbidity and mortality worldwide. Transplantation of human placental mesenchymal stem cells (hPMSCs) has been considered as an alternative therapy. However, the underlying mechanisms and the appropriate time window for hPMSC transplantation are not well understood. Methods We established mouse models of CCl4-injured LF and administered hPMSCs at different stages of LF once a week for 2 weeks. The therapeutic effect of hPMSCs on LF was investigated, according to histopathological and blood biochemical analyses. In vitro, the effect of hPMSCs and the secretomes of hPMSCs on the inhibition of activated HSCs was assessed. RNA sequencing (RNA-seq) analysis, real-time PCR array, and western blot were performed to explore possible signaling pathways involved in treatment of LF with hPMSCs. Results hPMSC treatment notably alleviates experimental hepatic fibrosis, restores liver function, and inhibits inflammation. Furthermore, the therapeutic effect of hPMSCs against mild-to-moderate LF was significantly greater than against severe LF. In vitro, we observed that the hPMSCs as well as the secretomes of hPMSCs were able to decrease the activation of HSCs. Mechanistic dissection studies showed that hPMSC treatment downregulated the expression of fibrosis-related genes, and this was accompanied by the upregulation of Caveolin-1 (Cav1) (p < 0.001). This suggested that the amelioration of LF occurred partly due to the restoration of Cav1 expression in activated HSCs. Upregulation of Cav1 can inhibit the TGF-β/Smad signaling pathway, mainly by reducing Smad2 phosphorylation, resulting in the inhibition of activated HSCs, whereas this effect could be abated if Cav1 was silenced in advance by siRNAs. Conclusions Our findings suggest that hPMSCs could provide multifaceted therapeutic benefits for the treatment of LF, and the TGF-β/Cav1 pathway might act as a therapeutic target for hPMSCs in the treatment of LF.

In this work, a sialic acid (SA)-imprinted thermo-responsive hydrogel layer was prepared for selective capture and release of cancer cells. The SA-imprinting process was performed at 37 °C using thermo-responsive functional monomer, thus generating switchable SA-recognition sites with potent SA binding at 37 °C and weak binding at a lower temperature (e.g., 25 °C). Since SA is often overexpressed at the glycan terminals of cell membrane proteins or lipids, the SA-imprinted hydrogel layer could be used for selective cancer cell recognition. Our results confirmed that the hydrogel layer could efficiently capture cancer cells from not only the culture medium but also the real blood samples. In addition, the captured cells could be non-invasively released by lowing the temperature. Considering the non-invasive processing mode, considerable capture efficiency, good cell selectivity, as well as the more stable and durable SA-imprinted sites compared to natural antibodies or receptors, this thermo-responsive hydrogel layer could be used as a promising and general platform for cell-based cancer diagnosis.

Energy storage film is one of the most important energy storage materials, while the performance of commercial energy storage films currently cannot meet the growing industrial requirements. Hence, this work presents a h-BN/PVDF/h-BN sandwich composite structure film prepared by laminating a large area of ultrathin hexagonal boron nitride (h-BN) and polyvinylidene fluoride (PVDF), the existence of which was confirmed by using an optical microscope and elemental composition analysis based on scanning electron microscopy and X-ray diffraction. This film has an ultrahigh dielectric strength of 464.7 kV/mm and a discharged energy density of up to 19.256 J/cm3, which is much larger than the commercial energy storage film biaxially oriented polypropylene (BOPP) (

A simple and effective method for preparing a non-metallic ion-doped nickel-supported catalyst is reported. Using economical and recyclable fibre raw materials as carriers, nickel-supported catalysts were prepared by adsorption and reduction at room temperature. The nanoparticles dispersed and anchored on a rational support, efficiently inhibiting their aggregation and thus enhancing the catalytic activity. For the model catalytic hydrogenation of 4-nitrophenol by NaBH4, the N-B-NiP/steam-exploded poplar (SEP) and N-B-Ni5Fe5P/SEP catalysts exhibited much better catalytic performances than the other recently reported catalysts in terms of the catalytic activity (the reaction was completed within 10 min for both aforementioned catalysts), reaction rate constant (0.19 and 0.344 min−1, respectively) and the activity factor K (19 and 34.4 min−1·g−1, respectively). The catalysts showed activities for electrocatalytic hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) under ambient conditions. In general, the reported preparation method of nickel-supported catalysts is convenient, economical and environment-friendly, and is agreement with many green chemistry and sustainable development principles; further, it employs widely available starting materials.

Partial discharge (PD) as one of well-known signatures of defects in the insulation system of high voltage equipment has been studied over eight decades. It is of a great interest to power grid operators and owners to identify and distinguish local weak spots in insulation system of the key components of power system by using the obtained PD information to make timely decision thus to avoid any unexpected failures in the system. This article reviews the research progress of PD in high voltage apparatus, including motors and generators, cables, transformers and gas insulated equipment, with attempts to assess the severity of different types of PD initiating defects as well as key PD features that can be selected for classifying defects. Experimental and on-site test results for each type of discharge and defect associated are summarized and discussed. Also, development of these defects during operation of equipment caused by changes in physical and chemical parameters of defect and/or insulation, and its impact on phase-resolved PD pattern variation are thoroughly explained. It is expected that this paper can provide a comprehensive guideline for PD data analysis of available PD information extracted by conventional PD acquisition instruments for both engineers and asset managers of high voltage apparatus.

Purpose: This study evaluated the diagnostic values of the extent of lung injury manifested in non-contrast enhanced CT (NCCT) images, the inflammatory and immunological biomarkers C-reactive protein (CRP) and lymphocyte for detecting acute cardiac injury (ACI) in patients with COVID-19. The correlations between the NCCT-derived parameters and arterial blood oxygen level were also investigated. Methods: NCCT lung images and blood tests were obtained in 143 patients with COVID-19 in approximately two weeks after symptom onset, and arterial blood gas measurement was also acquired in 113 (79%) patients. The diagnostic values of normal, moderately and severely abnormal lung parenchyma volume relative to the whole lungs (RVNP, RVMAP, RVSAP, respectively) measured from NCCT images for detecting the heart injury confirmed with high-sensitivity troponin I assay was determined. Results: RVNP, RVMAP and RVSAP exhibited similar accuracy for detecting ACI in COVID-19 patients. RVNP was significantly lower while both RVMAP and RVSAP were significantly higher in the patients with ACI. All of the NCCT-derived parameters exhibited poor linear and non-linear correlations with PaO2 and SaO2. The patients with ACI had a significantly higher CRP level but a lower lymphocyte level compared to the patients without ACI. Combining one of these two biomarkers with any of the three NCCT-derived parameter further improved the accuracy for predicting ACI in patients with COVID-19. Conclusion: The NCCT-delineated normal and abnormal lung parenchmyma tissues were statistically significant predictors of ACI in patients with COVID-19, but both exhibited poor correlations with the arterial blood oxygen level. The incremental diagnostic values of lymphocyte and CRP suggested viral infection and inflammation were closely related to the heart injury during the acute stage of COVID-19.

The Hangzhou White Chrysanthemum (Chrysanthemum morifolium Ramat) is one of the “Zhejiang eight flavors” in traditional Chinese medicine. The phosphatidylethanolamine-binding protein (PEBP) plays an important role in flowering and floral organ development. Even so, the biological role of PEBPs in the Hangzhou White Chrysanthemum has not been studied, which attracted us. Here, nine CmPEBP genes that contain the PF01161 domain were identified in the Hangzhou White Chrysanthemum for the first time, and their biological role in flowering was preliminarily studied. A phylogenetic analysis classified the CmPEBP genes into three subfamilies: MFT-like, TFL-like, and FT-like genes. The differential expression analysis was performed under different tissues and different stressors using qRT-PCR. It showed that each CmPEBP displayed tissue-specific expression patterns. Expression patterns in response to different temperatures and hormone stressors were investigated. They were finally demonstrated to be differentially expressed. TFL-like gene expression, which delayed reproductive growth, was upregulated under heat stress. Conversely, FT-like gene expression was upregulated under low temperatures. CmFT1 expression could be inhibited by GA (gibberellin), 6-BA (benzylaminopurine), ET (ethylene), and MeSA (methyl salicylate) but could be activated by IAA (indole-3-aceticacid), ABA (abscisic acid), and SA (salicylic acid) in the dark, whereas CmFT2 and CmFT3 expression levels were upregulated by ET, MeJA (methyl jasmonate), and ABA but were downregulated by 6-BA, SA, and MeSA. GA, IAA, SA, and MeSA inhibited CmTFL gene expression under light and dark treatments. Further research on CmPEBP genes in the Hangzhou White Chrysanthemum could better determine their roles in flowering and floral organ development, especially in response to the prolonged spraying of exogenous hormones.

To overcome the strikes from the tremendous noise of pseudorange and the integer ambiguity of carrier phase observation, we developed a novel dual-domain filtering method that integrates the traditional observation- and an innovative position- domain filtering method. The novel method employed the conventional Hatch's smoother to improve the precision of pseudorange at the observation-domain filtering part. At the position- domain filtering part, the proposed method constructs an accurate dynamical model for KF (Kalman filter) or ARKF (adaptive-robust KF) that relies on the TDCP (time differential carrier phase) velocity measurement technology. To assess the effectiveness of the novel method, we compared it with other methods under various system integration by measured data from IGS (International GNSS Service) MGEX (Multi-GNSS Experiment) and dynamic data collected at CUMT (China University of Mining and Technology). The static numerical experiments obtained from IGS datasets show that the ARKF improves the precision of 60/84 and 55/84 situations' directions compared with the LS method based on OP (original pseudorange) and SP (smoothed pseudorange), respectively, and Hatch's smother improves the precision of all situations' directions. The experiment results prove that both types of observation- and position- domain filtering methods can improve positioning precision. Also, the novel dual-domain filtering improved the precision of 80/84 situations' directions compared with the LS method. Moreover, the dynamic experiment shows that the novel method can improve all of the situations' directions except the N (North) direction provided by KF base on SP under GC and U (Upon) direction provided by LS base on SP under GR. The average of improved accuracy is 0.212m, 0.346m, and 0.588m at the E (East), N, U direction and its corresponding average percentage of improved accuracy is 30.2%, 60.2%, and 26.7%, respectively, which proves the novel dual-domain filtering method provided the best performance among the tested algorithms.

In electrical engineering, it is of great importance to monitor partial discharge (PD) of high voltage apparatus. However, on-site PD signal easily gets corrupted by white noise, and hence denoising the measured PD signal is necessary to acquire pure PD. In traditional method, single wavelet and regular thresholding are utilized. By combining wavelets of the same family, dual-tree complex wavelet pairs can be constructed. Specific combinations are approximately translation invariant, and they are also able to achieve better denoising effect without sophisticated computation. Meanwhile, considering the correlation between adjacent wavelet coefficients, the block thresholding is employed. In this paper, it is proposed to combine wavelet pair and block thresholding for PD denoising. There are four combinations based on single wavelet/wavelet pair and regular thresholding/block thresholding, and they are compared with each other. Based on a numerical study, the results demonstrate that the proposed algorithm outperforms the traditional method.