Search

Your search keyword '"CHEN T H"' showing total 1,195 results
Start Over Author "CHEN T H"
1,195 results on '"CHEN T H"'

5. Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study

Author

Gottlieb, DJ, Hek, K, Chen, T-H, Watson, NF, Eiriksdottir, G, Byrne, EM, Cornelis, M, Warby, SC, Bandinelli, S, Cherkas, L, Evans, DS, Grabe, HJ, Lahti, J, Li, M, Lehtimäki, T, Lumley, T, Marciante, KD, Pérusse, L, Psaty, BM, Robbins, J, Tranah, GJ, Vink, JM, Wilk, JB, Stafford, JM, Bellis, C, Biffar, R, Bouchard, C, Cade, B, Curhan, GC, Eriksson, JG, Ewert, R, Ferrucci, L, Fülöp, T, Gehrman, PR, Goodloe, R, Harris, TB, Heath, AC, Hernandez, D, Hofman, A, Hottenga, J-J, Hunter, DJ, Jensen, MK, Johnson, AD, Kähönen, M, Kao, L, Kraft, P, Larkin, EK, Lauderdale, DS, Luik, AI, Medici, M, Montgomery, GW, Palotie, A, Patel, SR, Pistis, G, Porcu, E, Quaye, L, Raitakari, O, Redline, S, Rimm, EB, Rotter, JI, Smith, AV, Spector, TD, Teumer, A, Uitterlinden, AG, Vohl, M-C, Widen, E, Willemsen, G, Young, T, Zhang, X, Liu, Y, Blangero, J, Boomsma, DI, Gudnason, V, Hu, F, Mangino, M, Martin, NG, O'Connor, GT, Stone, KL, Tanaka, T, Viikari, J, Gharib, SA, Punjabi, NM, Räikkönen, K, Völzke, H, Mignot, E, and Tiemeier, H

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Human Genome, Sleep Research, Genetics, Health Disparities, 2.1 Biological and endogenous factors, Good Health and Well Being, Adult, Black or African American, Aged, Dyssomnias, Female, Genetic Association Studies, Genome-Wide Association Study, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Self Report, Sleep, White People, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Clinical sciences, Biological psychology, Clinical and health psychology
Abstract

Usual sleep duration is a heritable trait correlated with psychiatric morbidity, cardiometabolic disease and mortality, although little is known about the genetic variants influencing this trait. A genome-wide association study (GWAS) of usual sleep duration was conducted using 18 population-based cohorts totaling 47 180 individuals of European ancestry. Genome-wide significant association was identified at two loci. The strongest is located on chromosome 2, in an intergenic region 35- to 80-kb upstream from the thyroid-specific transcription factor PAX8 (lowest P=1.1 × 10(-9)). This finding was replicated in an African-American sample of 4771 individuals (lowest P=9.3 × 10(-4)). The strongest combined association was at rs1823125 (P=1.5 × 10(-10), minor allele frequency 0.26 in the discovery sample, 0.12 in the replication sample), with each copy of the minor allele associated with a sleep duration 3.1 min longer per night. The alleles associated with longer sleep duration were associated in previous GWAS with a more favorable metabolic profile and a lower risk of attention deficit hyperactivity disorder. Understanding the mechanisms underlying these associations may help elucidate biological mechanisms influencing sleep duration and its association with psychiatric, metabolic and cardiovascular disease.

Published
2015

33. Deep Learning for Financial Engineering

Author

Chen, M.-Y., Sangaiah, A.K., Chen, T.-H., Lughofer, E.D., Egrioglu, E., Chen, M.-Y., Sangaiah, A.K., Chen, T.-H., Lughofer, E.D., and Egrioglu, E.

Published
2022

50. Cabauw Experimental Results from the Project for Intercomparison of Land-Surface Parameterization Schemes

Author

Chen, T. H., Henderson-Sellers, A., Milly, P. C. D., Pitman, A. J., Beljaars, A. C. M., Polcher, J., Abramopoulos, F., Boone, A., Chang, S., Chen, F., Dai, Y., Desborough, C. E., Dickinson, R. E., Dümenil, L., Ek, M., Garratt, J. R., Gedney, N., Gusev, Y. M., Kim, J., Koster, R., Kowalczyk, E. A., Laval, K., Lean, J., Lettenmaier, D., Liang, X., Mahfouf, J.-F., Mengelkamp, H.-T., Mitchell, K., Nasonova, O. N., Noilhan, J., Robock, A., Rosenzweig, C., Schaake, J., Schlosser, C. A., Schulz, J.-P., Shao, Y., Shmakin, A. B., Verseghy, D. L., Wetzel, P., Wood, E. F., Xue, Y., Yang, Z.-L., and Zeng, Q.

Published
1997

Catalog

Books, media, physical & digital resources
See catalog results