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AIM: To investigate the role of histidine-rich glycoprotein(HRG)in the neovascularization of diabetic retinopathy in rats.METHODS: Streptozocin(STZ)-induced diabetic Sprague-Dawley(SD)rats were utilized as an experimental model, the protein expression of HRG and vascular endothelial growth factor(VEGF)in the retinas of normal(Wild type, WT)and diabetic(diabetic mellitus, DM)groups was detected using Western blot(WB). The protein expression of HRG in high-glucose-induced human retinal microvascular endothelial cells(hRMECs)was verified by WB after transfection with HRG small interfering RNA(siRNA)low-expression sequences. The optimal si-HRG#298 sequence was selected for further experiments. In the animal experiment, HRG gene silencing was achieved using an adeno-associated virus(AAV)vector, with AAV2-sh-NC and AAV2-sh-HRG#298 serving as the HRG gene silencing group and the HRG empty vector control group, respectively. The protein expression of HRG and VEGF in each group was then detected by WB following the verification of HRG protein expression. Retinal structural changes were observed by HE staining, and neovascularization changes were observed by PAS staining.RESULTS: HE staining found that the retinal structure in the DM group was disordered, the number of cells in the ganglion cell layer decreased, the number of cells in the inner and outer nuclear layers decreased, and the total retinal thickness also decreased(P

As one kind of advanced high temperature structural and functional materials, it is necessary for fiber reinforced silicon carbide matrix composites (SiC CMCs) in the field of thermal management (TM) to combine the efficient heat transfer and high temperature heat resistance. Common fibers reinforced SiC CMCs, such as carbon fibers reinforced SiC CMCs (Cf/SiC or Cf/C-SiC), silicon carbide based fiber reinforced SiC CMCs (SiCf/SiC), etc., have a low degree of graphitization of the reinforcing fiber and are difficult to form an effective heat transport network. The latest research progress on the preparation and properties of fiber reinforced SiC CMCs with highly thermal conductivity was reviewed in this paper. The heat transport ability of fiber reinforced SiC CMCs can be improved by introducing highly thermal conductive phase, optimizing interfacial structure, making silicon carbide crystal coarse-grained, and designing preform structure. Moreover, the development of the fiber reinforced SiC CMCs with highly thermal conductivities was prospected, that is, comprehensively considering the factors that affect the performance of SiC CMCs, flexibly using the structure-activity relationship between the microstructure and properties of the composites, in order to prepare fiber reinforced SiC CMCs with stable size, excellent properties.

We explore the kinetic energy partitions between electrons and ions in the 2-D magnetostatic equilibria called Arnold–Beltrami–Childress (ABC) fields, using particle-in-cell (PIC) numerical simulations. We cover a wider range of ion–electron temperature combinations and get different results compared to previous studies of the Harris-layer-type magnetic reconnection simulations. We find that the initial ion–electron enthalpy ratio is an important indicator. The particle species that dominates the total enthalpy will also dominate the kinetic energy gains and the momentum distribution peaks, but the other species have higher nonthermal energy fractions because both species show similar maximum energies.

Volatile organic compounds (VOC) are important sources of environmental pollution. Several commonly used techniques for the treatment of VOC are reviewed. Recovery techniques can be classified into absorption, adsorption, condensation and membrane separation. Destruction techniques include biodegradation, photocatalysis, low-temperature plasma and combustion. The basic principle, applicable conditions, advantages and disadvantages of the above technologies are discussed. By contrast, the rotational regenerative combustion method has a broad prospect. Suggestions on the improvement of rotary regenerative combustion technology are presented. The treatment of VOC requires comprehensive consideration of the advantages and disadvantages of various technologies.

A mathematical model of a 10 MeV industrial electron accelerator was established by using GEANT4 Monte Carlo software package, and the dose distribution of homogeneous products under different densities were obtained by simulation calculation. Combined with the Qt interface design and development platform, the calculated data were designed by C++ programming. The dose distribution and dose uniformity ratio of different product densities and thicknesses were obtained. In addition, Qt was used to interface the product irradiation dose and the conveyor device transmission speed calculation, daily process management, and dose field distribution data drawing, forming the irradiation process interface software. The accuracy of GEANT4 simulation calculation results and process software was verified by using dose distribution tests and industry research results. The experimental results revealed that the calculation results and test results are in good agreement. The irradiation technology interface software, which can be applied to calculate the irradiation effect and transmission speed of products and other main process parameters in real time, is a useful tool for product irradiation technology design.

The Beijing genotype is the most common type of tuberculosis in Jiangxi Province, China. The association of population characteristics and their prevalence in the development of recent transmission is still unclear. 1,433 isolates were subjected to drug-resistant tests and MIRU-VNTR analysis. We compared differences in demographic characteristics and drug resistance patterns between the Beijing and non-Beijing family strains. We also explored the association of the clustering rate with the Beijing genotype of Mycobacterium tuberculosis. The Beijing genotype was dominant (78.16%). The results of MIRU-VNTR showed that 775 of 1,433 strains have unique patterns, and the remaining gather into 103 clusters. A recent transmission rate was 31.54% (452/1,433). The Beijing genotype strains were more likely to spread among the recurrent population (p = 0.004), people less than 50 years of age (p = 0.02 or 0.003), and the personnel in the northern regions (p = 0.03). Drug resistance patterns did not show significant differences between Beijing and non-Beijing genotype isolates. Furthermore, we found that HIV-positive cases had a lower clustering rate (p = 0.001). Our results indicated that the recurrent population and people under 50 years of age were more likely to be infected with the Beijing genotype of M. tuberculosis. The strains from the Beijing family were easier to cluster compared to strains isolated from the non-Beijing family. Social activity and AIDS substantially impacted the clustering rate of the Beijing genotype of M. tuberculosis. Multidrug resistant M. tuberculosis affected Beijing genotype transmission.

Aims: (1) Quantitatively characterize the Pseudo Fibrosis Burden (PFB) of Left Atrial Appendage (LAA) Trabecular Musculi Pectinati (TMP) in patients with atrial fibrillation based on histological analysis; (2) Explore the passive dynamic properties of LAA TMP based on uniaxial tensile experiments and determine the hyperelastic constitutive parameters; (3) Explore samples Effects of different storage conditions on the mechanical properties of left atrial appendage TMP. Methods: Fifty TMP were isolated from the resected LAAs of 21 patients with atrial fibrillation and stored (23 strips in the -78°C cryopreservation group and 27 strips in the 4°C normal temperature storage group). The TMP stress-strain curve was obtained through uniaxial tension. According to this curve, the elastic modulus of the low strain zone (EMLS) and the high strain zone (EMHS) were respectively defined. The correlation between the TMP’s diameter and its mechanical properties and the impact of storage temperature on TMP mechanics were analyzed. Four strain energy functions were used to fit the TMP stress-strain curve to obtain the hyperelastic model constitutive parameters. Histological analysis of the axial and transverse microstructure of TMP was performed using Verhoeff-Van Gieson double staining method of Elastic fibers and collagen fibers (EVG) and Masson staining respectively, and the Pseudo Fiber Burden (PFB) was calculated. Analyze the correlation between mechanical properties and PFB. Results: Cryopreservation reduced the elastic modulus in the hyperelastic stage of TMP mechanical properties. EMLS (r=-0.7228, P

Introduction Depression is the most dominant non-motor symptom of Parkinson’s disease (PD), with a prevalence of up to 50%, and can lead to a range of psychiatric and psychological problems that can affect quality of life and overall functioning. While several randomised controlled trials (RCTs) have tested the effect of certain non-pharmacological interventions on the outcome of PD depression symptoms, the comparative benefits and harms of these remain unclear. We will conduct a systematic review and network meta-analysis to compare the efficacy and safety of different non-pharmacological interventions for patients with PD depression.Methods and analysis We will search PubMed, Web of Science, Cochrane, Embase, Google Scholar, the Chinese National Knowledge Infrastructure, the Chinese Biomedical Literature Database, WanFang Data and the Chongqing VIP Database from their inception date to June 2022. The studies will be limited to results published in English or Chinese. The primary outcomes will be the changes in the depressive symptoms, while secondary outcomes will include adverse effects and the quality of life. Two researchers will screen those documents that meet the inclusion criteria, extracting data according to the preset table and evaluating the methodological quality of the included studies using the Cochrane Risk of Bias 2.0 Tool. The STATA and ADDIS statistical software will be used to conduct a systematic review and network meta-analysis. A traditional pairwise meta-analysis and a network meta-analysis will be performed to compare the efficacy and safety of different non-pharmacological interventions, ensuring the robustness of the findings. The Grading of Recommendations Assessment, Development and Evaluation system will be used to assess the overall quality of the body of evidence associated with the main results. The publication bias assessment will be conducted using comparison-adjusted funnel plots.Ethics and dissemination All the data for this study will be extracted from published RCTs. As a literature-based systematic review, this study does not require ethical approval. The results will be disseminated through peer-reviewed journals and national/international conference presentations.PROSPERO registration number CRD42022347772.

BackgroundIt is still controversial whether or not serum uric acid, a key risk for coronary heart disease, is significantly associated with prognosis of acute myocardial infarction (AMI) . And there are rare large-scale and multicenter studies on serum uric acid and long prognosis of AMI in China.ObjectiveTo investigate the relationship between serum uric acid and long-term prognosis in AMI patients.MethodsOne thousand and ninety-eight AMI patients from 9 hospitals (Chengdu First People's Hospital, Chengdu Second People's Hospital, the Third People's Hospital of Chengdu, the First Affiliated Hospital of Chengdu Medical College, Dujiangyan Medical Center, Pidu District People's Hospital, Chengdu, Shuangliu District First People's Hospital, Jintang First People's Hospital, the People's Hospital of Pengzhou) in Chengdu during September 2016 to July 2019 were consecutively reSScruited. Baseline data were collected via the electronic medical record system of each hospital by trained professionals, including: (1) demographic data: age, gender, prevalence of smoking; (2) clinical complications and related information: hypertension, diabetes, blood pressure, heart rate, Killip class, AMI type (NSTEMI or STEMI) , prevalence of percutaneous coronary intervention (PCI) ; (3) laboratory parameters: serum SScreatinine (Scr) , uric acid (UA) , triglyceride (TG) , total cholesterol (TC) , low-density lipoprotein cholesterol (LDL-C) , high-density lipoprotein cholesterol (HDL-C) , estimated glomerular filtration rate (eGFR) ; (4) post-discharge medication: aspirin, clopidogrel/tigrelol, statins, Beta-blockers, ACEI/ARB, diuretics. Baseline data were compared between patients with and without major adverse cardiovascular and cerebrovascular events (MACCE) during post-discharge follow-up. Then, prognosis was compared aSScross UA tertile subgroups〔A: UA

In this paper, we establish equivalent parameter conditions for the validity of multiple integral half-discrete Hilbert-type inequalities with the nonhomogeneous kernel G(nλ1∥x∥m,ρλ2)G\left({n}^{{\lambda }_{1}}\parallel x{\parallel }_{m,\rho }^{{\lambda }_{2}}\hspace{-0.16em}) (λ1λ2>0{\lambda }_{1}{\lambda }_{2}\gt 0) and obtain best constant factors of the inequalities in specific cases. In addition, we also discuss their applications in operator theory.

A comprehensive study of the multiscale homogenized thermal conductivities and thermomechanical properties is conducted towards the filament groups of European Advanced Superconductors (EAS) strand via the recently proposed Multiphysics Locally Exact Homogenization Theory (LEHT). The filament groups have a distinctive two-level hierarchical microstructure with a repeating pattern perpendicular to the axial direction of Nb3Sn filament. The Nb3Sn filaments are processed in a very high temperature between 600 and 700°C, while its operation temperature is extremely low, −269°C. Meanwhile, Nb3Sn may experience high heat flux due to low resistivity of Nb3Sn in the normal state. The intrinsic hierarchical microstructure of Nb3Sn filament groups and Multiphysics loading conditions make LEHT an ideal candidate to conduct the homogenized thermal conductivities and thermomechanical analysis. First, a comparison with a finite element analysis is conducted to validate effectiveness of Multiphysics LEHT and good agreement is obtained for the homogenized thermal conductivities and mechanical and thermal expansion properties. Then, the Multiphysics LEHT is applied to systematically investigate the effects of volume fraction and temperature on homogenized thermal conductivities and thermomechanical properties of Nb3Sn filaments at the microscale and mesoscale. Those homogenized properties provide a full picture for researchers or engineers to understand the Nb3Sn homogenized properties and will further facilitate the material design and application.

This study aimed to develop a multi-long noncoding RNA (lncRNA) signature for the prediction of gastric cancer (GC) based on differential gene expression between recurrence and nonrecurrence patients.

Citrus is an important agricultural product in China and globally, and citrus production in China plays a vital role in global citrus patterns; specifically, spatial changes in these patterns affect the supply of citrus in China and have an important impact on the international citrus trade. In this study, the industrial concentration, exploratory data analysis, industrial gravity model, and spatial Durbin model were used to analyze the spatial evolution characteristics of and factors driving citrus production in China. The results showed that, from 1978 to 2015, China's citrus production space showed an expanding trend, which could be divided into a rapid growth period (1978-1991), low growth period (1992-2000), and steady growth period (2001-2015). The citrus production space in China is mainly concentrated in Southwest, Central South, and East China, with a spatial structure of "cold in the north and hot in the South." Citrus production space has a significant positive spatial autocorrelation on the provincial scale, showing a significant geographical agglomeration; the agglomeration first drops sharply, following which it fluctuates and rises. Since 2000, the center of the production space has continuously moved to the Southwest; the trend of "moving to the West and expanding to the South" is evident. China's citrus production space has gradually changed from the original natural drive to the "natural society" drive. The endowment of natural resources determines the basic space of citrus production in China, where social and economic factors are important reasons for changes in citrus production space. Among the market location factors, road transportation and fruit consumption significantly affect the citrus production space positively. The increase in road network density improves the economic location of the production area, and the increase in residents' incomes expands the demand for citrus consumption; therefore, for each 1% increase in road network density and income, the citrus area increases by 0.192% and 0.107%, respectively. Among the production factors, labor input and water conservancy irrigation have positive effects on citrus production space; with a 1% increase in these factors, the citrus area increases by 0.934% and 0.094%, respectively. Regarding social and economic factors, the loss of rural labor as a result of non-agricultural employment opportunities has a strong negative effect on the production space of citrus. The citrus area is reduced by 1.365% for each 1% increase. New varieties and new technologies brought about by scientific and technological progress positively affect citrus production space, and the citrus area increases by 0.058% for every 1% increase in this factor. The direct effect of per capita grain possession is negative, and the indirect effect is positive, indicating that with regard allocating limited land resources, local land must first meet the food security and inhibit the increase in citrus area. The increase in the per capita share in neighboring areas can meet the local food security and promote the increase of citrus area through food circulation.

Lacunopsis Deshayes, 1876 is restricted to South Asia and shows a remarkable regional distribution. Fifteen species have been reported from the lower Mekong River area of Laos, Cambodia, Thailand and Vietnam. Two species Lacunopsis auris Y.-Y. Liu, Y.-X. Wang & W.-Z. Zhang, 1980 and L. yunnanensis Y.-Y. Liu, Y.-X. Wang & W.-Z. Zhang, 1980 occurred in the Yunnan Province of China. The most recent treatments of Lacunopsis date back to the 1970's and the 1980's, therefore detailed information on anatomy and DNA analysis is lacking.A new species of freshwater snail (Gastropoda, Pomatiopsidae), L. yuxiensis sp. nov., is described, based on samples collected from Fuxian Lake (Yunnan, China). The new species is characterized by a solid shell and dark red and yellow spiral ribs on the whorls, reminiscent of marine gastropods of the family Trochidae. In addition to a description of the shell morphology and radula, molecular data are presented for the first time. This compilation of faunal and taxonomic data provides relevant information for use in conservation efforts. Additional molecular data may prove helpful for both refining current knowledge on the morphological variability within this species and verifying the degree of cryptic diversity of this genus.

The locally-exact homogenization theory is further extended to investigate the homogenized and localized electric behavior of unidirectional composite and porous materials. Distinct from the classical and numerical micromechanics models, the present technique is advantageous by developing exact analytical solutions of repeating unit cells (RUC) with hexagonal and rhomboid geometries that satisfy the internal governing equations and fiber/matrix interfacial continuities in a point-wise manner. A balanced variational principle is proposed to impose the periodic boundary conditions on mirror faces of an RUC, ensuring rapid convergence of homogenized and localized responses. The present simulations are validated against the generalized Eshelby solution with electric capability and the finite-volume direct averaging micromechanics, where excellent agreements are obtained. Several micromechanical parameters are then tested of their effects on the responses of composites, such as the fiber/matrix ratio and RUC geometry. The efficiency of the theory is also proved and only a few seconds are required to generate a full set of properties and concomitant local electric fields in an uncompiled MATLAB environment. Finally, the related programs may be encapsulated with an input/output (I/O) interface such that even non-professionals can execute the programs without learning the mathematical details.

As the most important safety component of the construction elevators, the periodic detection of anti-falling safety devices is particularly important. The embedded detection system based on the Android platform of the SAJ30/40 gear progressive anti-falling safety device was designed, the angle sensor was used to measure the rotation angle of cone hub of the anti-falling safety device and the speed sensor was used to measure the real-time running speed of the elevator respectively, the data was processed by the upper computer analysis software, the braking distance and the operating speed of the anti-falling safety device were output. The test results of the method of the field test frame show that the detection system can measure the braking distance of the anti-falling safety device and other testing parameters accurately, and the measurement accuracy of the braking distance is ±1 millimeter.

NAC (for NAM, ATAF1-2, and CUC2) proteins are one of the largest transcription factor families in plants. They have various functions and are closely related to developmental processes of fruits. Tomato (Solanum lycopersicum) is a model plant for studies of fruit growth patterns. In this study, the functional characteristics and action mechanisms of a new NAC-type transcription factor, SlNAC3 (SGN-U568609), were examined to determine its role in tomato development and ripening. The SlNAC3 protein was produced by prokaryotic expression and used to immunize New Zealand white rabbits to obtain a specific polyclonal antibody against SlNAC3. By co-immunoprecipitation and MALDI-TOF-MS assays, we showed that there was an interaction between the SlNAC3 protein and Polygalacturonase-2 (PG-2), which is related to the ripening and softening of fruit. Chromatin immunoprecipitation assays revealed the genome of the highly stress-tolerant Solanum pennellii chromosome 10 (sequence ID, HG975449.1), further demonstrating that SlNAC3 is a negative regulator of drought and salinity stress resistance in tomato, consistent with previous reports. These results indicate that SlNAC3 is not only involved in abiotic stress, but also plays a necessary role in mediating tomato ripening.

Transformer can effectively model long rang dependency, but suffer from uncapable to extract local feature patterns. While CNNs exploit local features effectively. In this paper, we seek to combine convolution and Transformers improves over using them individually, and propose improved features using convolution-augmented transformers for keyword spotting. The convolution-augmented transformers are constructed with a ResNet front-end and a convolution-augmented transformers back-end in series. Using this improved feature for keyword spotting task. The results show that the improved features using convolution- augmented transformers can yield at least 3% improvement compared with other features.

C31H58ClN7, monoclinic, P21/c (no. 14), a = 29.9370(18) Å, b = 15.6432(8) Å, c = 14.2792(8) Å, β = 90.819(2)°, V = 6686.4(6) Å3, Z = 8, Rgt(F) = 0.0671, wRref(F2) = 0.1925, T = 173(2) K.

It can change magnitude and direction of fault current of distributed network after distributed generation was connected to power distribution system, which made fault diagnosis of power distribution system complicated. For the above problem, a fault diagnosis method of distribution network based on power direction criterion and Petri net was proposed. The method uses uploading and measured double fault information to realize redundant error correcting, and can accurately and quickly diagnose fault areas, so as to improve fault diagnosis accuracy and fault tolerance of distribution system with distributed generation. At the same time, the method uses unique graphic description and parallel processing ability of Petri nets to ensure universality of fault location model and rapidity of fault diagnosis. The example simulation results verify feasibility and effectiveness of the proposed method.