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Introduction: Walking stands as the most prevalent physical activity in the daily lives of individuals and is closely associated with physical functioning and the aging process. Nonetheless, the precise cause-and-effect connection between walking and aging remains unexplored. The epigenetic clock emerges as the most promising biological indicator of aging, capable of mirroring the biological age of the human body and facilitating an investigation into the association between walking and aging. Our primary objective is to investigate the causal impact of walking with epigenetic age acceleration (EAA). Methods: We conducted a two-sample two-way Mendelian randomization (MR) study to investigate the causal relationship between walking and EAA. Walking and Leisure sedentary behavior data were sourced from UK Biobank, while EAA data were gathered from a total of 28 cohorts. The MR analysis was carried out using several methods, including the inverse variance weighted (IVW), weighted median, MR-Egger, and robust adjusted profile score (RAPS). To ensure the robustness of our findings, we conducted sensitivity analyses, which involved the MR-Egger intercept test, Cochran's Q test, and MR-PRESSO, to account for and mitigate potential pleiotropy. Results: The IVW MR results indicate a significant impact of usual walking pace on GrimAge (BETA = − 1.84, 95% CI (− 2.94, − 0.75)), PhenoAge (BETA = − 1.57, 95% CI (− 3.05, − 0.08)), Horvath (BETA = − 1.09 (− 2.14, − 0.04)), and Hannum (BETA = − 1.63, 95% CI (− 2.70, − 0.56)). Usual walking pace is significantly associated with a delay in epigenetic aging acceleration (EAA) (P < 0.05). Moreover, the direction of effect predicted by the gene remained consistent across RAPS outcomes and sensitivity MR analyses. There is a lack of robust causal relationships between other walking conditions, such as walking duration and walking frequency, on EAA (P > 0.05). Conclusion: Our evidence demonstrates that a higher usual walking pace is associated with a deceleration of the acceleration of all four classical epigenetic clocks acceleration. Key messages: In recent years, observational studies have found that there is a correlation between walking and aging, but the specific relationship is not clear We used a Mendelian randomization approach to test the causal effect of walking and sedentarism on epigenetic clock acceleration Mendelian randomization studies have found that faster walking speed may delay physiological aging through causal analysis at the genetic level [ABSTRACT FROM AUTHOR]

Corn straw is an important non-grain feed resource, which is not suitable for feeding animals directly because of its high crude fiber content. Biological fermentation technology can reduce the content of anti-nutrient factors in corn stalk, improve its nutritional value and feeding value, and is widely used in the chemical production in corn stalk feed because of its simple operation and green environmental protection. The bio-fermented corn stalk plays a significant role in regulating animal health and has a broad application prospect in animal breeding. The nutritional characteristics of corn stalk before and after biological fermentation, the methods of biological fermentation of corn stalk and its application in animal feed were reviewed in this paper to provide a reference for the rational application of corn stalk in animal production. [ABSTRACT FROM AUTHOR]

Background: Requirements of blood transfusions rise rapidly in China. Improving the efficiency of blood donation could help maintaining sufficient blood supplement. We conducted a pilot research to investigate the reliability and safety of collecting more units of red blood cell by apheresis. Methods: Thirty‐two healthy male volunteers were randomized into two groups: red blood cell apheresis (RA) (n = 16) and whole blood (WB) donation (n = 16). RA group donated individualized RBC volumes by apheresis according to the volunteers' basal total blood volumes and haematocrit levels, WB group donated 400 mL whole blood. All volunteers were scheduled seven visit times in 8 weeks' study period. The cardiovascular functions were assessed by laboratory examinations, echocardiography and cardiopulmonary functional tests. All results were compared between groups at the same visit time and compared between visit 1(before donation) and other visit times within the same group. Results: The average donated RBC volume in RA group and in WB group was 627.25 ± 109.74 mL and 175.28 ± 8.85 mL, respectively(p < 0.05); the RBC, haemoglobin and haematocrit levels changed significantly between times and between groups (p < 0.05). Cardiac biomarker levels such as NT‐proBNP, hs‐TnT and CK‐MB did not change significantly between times or between groups (p > 0.05). The echocardiographic and cardiopulmonary results did not change significantly between times or between groups during the whole study period(p > 0.05). Conclusions: We provided an efficient and secure method for RBC apheresis. By harvesting more RBC volumes at one single‐time, the cardiovascular functions did not change significantly compared with traditional whole blood donation. [ABSTRACT FROM AUTHOR]

We investigate the ionospheric responses to the 2014–2015 sudden stratospheric warming (SSW) event in winter and summer hemisphere by using ionosondes distributed in Equatorial Ionization Anomaly (EIA) crests. Daily mean value of foF2 at each station shows obvious semimonthly lunar tide (∼14.5‐day period) modulation from lower to higher latitude in both hemispheres during SSW period. Besides, lunar tide modulation in summer hemisphere is later than that in winter hemisphere, which can be explained by the planetary wave penetrating across the equator from winter to summer hemisphere. In addition, lunar semidiurnal tide extracted from foF2 presents evident enhancement after warming onset. Our results demonstrate the quasi 16‐day periodic oscillations in F region of EIA crests are caused by the enhanced lunar tide in dynamo wind of mesosphere and lower thermosphere region, which is due to the disturbances in the zonal mean wind distribution in connection with SSW.Plain Language Summary: The sudden stratospheric warming (SSW) is a large‐scale meteorological event in the winter polar stratosphere, and the connection between SSW and ionosphere variability is now well established observationally, however, the mechanisms responsible for generating the ionosphere disturbances remains an active area of research. In this study, we try to investigate the lunar tide modulation in ionospheric Equatorial Ionization Anomaly crest in both hemispheres and its latitudinal dependence during a minor SSW event. We analyze the possible mechanism for explaining the enhanced lunar modulation which occurs successively from lower to higher latitude.Key Points: Semimonthly lunar tide modulation in foF2 occurs in sequence from lower to higher latitude in Equatorial Ionization Anomaly crest of both hemispheres during sudden stratospheric warming (SSW)The peak of quasi 16‐day oscillation in foF2 also appears from lower to higher latitude in both hemispheres in sequenceLunar effect on foF2 in winter hemisphere is earlier than that in summer hemisphere during SSW [ABSTRACT FROM AUTHOR]