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268 results on '"CHEN, LUKUI"'

8. Beijing Declaration of International Association of Neurorestoratology (2023 Xi'an version)

Author

Huang, Hongyun, Chen, Lin, Sanberg, Paul R., Dimitrijevic, Milan, Shetty, Ashok K., Sharma, Hari Shanker, Wu, Ping, Bryukhovetskiy, Andrey, Al-Zoubi, Ziad M., Chopp, Michael, Young, Wise, Saberi, Hooshang, Moviglia, Gustavo, Sarnowska, Anna, Sharma, Alok, He, Xijing, Muresanu, Dafin F., Jeon, Sang Ryong, Feng, Shiqing, Cho, Kyoung-Suok, Alvarez, Edgardo O., Kuźma-Kozakiewicz, Magdalena, Kuffler, Damien, Otom, Ali, Herrera-Marschitz, Mario, Moniche, Francisco, Koliakos, Georgios, Ao, Qiang, Guo, Xiaodong, von Wild, Klaus R.H., Cheng, Liming, Al-Zoubi, Adeeb, Zhao, Jianhua, Guo, Xiaoling, Mao, Gengsheng, Han, Fabin, Hu, Yong, Xue, Mengzhou, Song, Jinggui, Zhang, Xinzhong, Chen, Xu, Chen, Lukui, Zheng, Zuncheng, Wang, Dong, Zhang, Wenchuan, Qiao, Liyan, Xiang, Guanghong, Liu, Jing, Zhao, Robert Chunhua, and Zhang, Qiqing

Published
2023
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9. Spinal Cord Injury or Dysfunction Quality of Life Rating Scale (SCIDQLRS) (IANR 2022 version)

Author

Huang, Hongyun, Sharma, Hari Shanker, Saberi, Hooshang, Chen, Lin, Sanberg, Paul R., Xue, Mengzhou, Sharma, Alok, Chen, Di, Siniscalco, Dario, Ramón-Cueto, Almudena, Xi, Haitao, Chen, Lukui, Feng, Shiqing, He, Xijing, Sun, Tiansheng, Li, Jianjun, Guo, Xiaoling, Feng, Yaping, Shen, Yixin, Wang, Fangyong, Zheng, Zuncheng, Guo, Xiaodong, Hu, Jianzhong, and Al Zoubi, Ziad M.

Published
2022
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13. Neural stem cell-derived exosomes: a cell-free transplant for potential cure of neurological diseases.

Author

HUANG, JIAJUN, WANG, WEI, LIN, WENTONG, CAI, HENGSEN, ZHU, ZHIHAN, AHMED, WAQAS, ZHANG, QIANKUN, LIU, JIALE, ZHANG, YIFAN, LI, RONG, LI, ZHINUO, KHAN, AHSAN ALI, LU, DENG, HU, YONG, and CHEN, LUKUI

Subjects
NEUROLOGICAL disorders, NEURONS, STEM cell transplantation, NERVOUS system, CELL communication
Abstract

Degeneration and death of nerve cells are inevitable with the occurrence and progression of nervous system disorders. Researchers transplanted neural stem cells into relevant areas, trying to solve the difficulty of neural cell loss by differentiating neural stem cells into various nerve cells. In recent years, however, studies have shown that transplanted neural stem cells help neural tissues regenerate and return to normal through paracrine action rather than just replacing cells. Exosomes are essential paracrine mediators, which can participate in cell communication through substance transmission. In this regard, this review mainly discusses the current research progress of neural stem cell-derived exosomes. This paper mainly introduces the self-regulation of neural stem cells (NSCs)-derived exosomes on neural stem cells to clarify the role of NSCs-derived exosomes in the nervous system; the therapeutic effect of NSCs-derived exosomes on various neurological diseases; introduces different studies of NSCs-derived exosomes, showing more in-depth research results of NSCs-derived exosomes. It presents some ideas to provide a reference for subsequent research on neural stem cell-derived exosomes. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Neural Stem Cell-Derived Small Extracellular Vesicles: key Players in Ischemic Stroke Therapy – A Comprehensive Literature Review

Author

Zhu,Zhihan, Zhang,Qiankun, Feng,Jia, Zebaze Dongmo,Sonia, Zhang,Qianqian, Huang,Songze, Liu,Xiaowen, Zhang,Guilong, Chen,Lukui, Zhu,Zhihan, Zhang,Qiankun, Feng,Jia, Zebaze Dongmo,Sonia, Zhang,Qianqian, Huang,Songze, Liu,Xiaowen, Zhang,Guilong, and Chen,Lukui

Abstract

Zhihan Zhu,1,* Qiankun Zhang,1,* Jia Feng,1 Sonia Zebaze Dongmo,1 Qianqian Zhang,1 Songze Huang,1 Xiaowen Liu,1 Guilong Zhang,2 Lukui Chen1 1Department of Neurosurgery, Southern Medical University Hospital of Integrated Traditional Chinese and Western Medicine, Southern Medical University, Guangzhou, Guangdong Province, People’s Republic of China; 2Department of Neurosurgery, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lukui Chen, Department of Neurosurgery, Southern Medical University Hospital of Integrated Traditional Chinese and Western Medicine, Southern Medical University, Guangzhou, People’s Republic of China, Email neuro_clk@hotmail.com Guilong Zhang, Department of Neurosurgery, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of China, Email longshe05@sina.comAbstract: Ischemic stroke, being a prominent contributor to global disability and mortality, lacks an efficacious therapeutic approach in current clinical settings. Neural stem cells (NSCs) are a type of stem cell that are only found inside the nervous system. These cells can differentiate into various kinds of cells, potentially regenerating or restoring neural networks within areas of the brain that have been destroyed. This review begins by providing an introduction to the existing therapeutic approaches for ischemic stroke, followed by an examination of the promise and limits associated with the utilization of NSCs for the treatment of ischemic stroke. Subsequently, a comprehensive overview was conducted to synthesize the existing literature on the underlying processes of neural stem cell-derived small extracellular vesicles (NSC-sEVs) transplantation therapy in the context of ischemic stroke. These mechanisms encompass neuroprotection, inflammatory response suppression, and endogenous n

Published
2024

21. Innovations in Breaking Barriers: Liposomes as Near-Perfect Drug Carriers in Ischemic Stroke Therapy

Author

Zhang,Qiankun, Huang,Songze, Liu,Xiaowen, Wang,Wei, Zhu,Zhihan, Chen,Lukui, Zhang,Qiankun, Huang,Songze, Liu,Xiaowen, Wang,Wei, Zhu,Zhihan, and Chen,Lukui

Abstract

Qiankun Zhang,* Songze Huang,* Xiaowen Liu, Wei Wang, Zhihan Zhu, Lukui Chen Department of Neurosurgery, Southern Medical University Hospital of Integrated Traditional Chinese and Western Medicine, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lukui Chen, Department of Neurosurgery, Southern Medical University Hospital of Integrated Traditional Chinese and Western Medicine, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China, Email neuro_clk@hotmail.comAbstract: Liposomes, noted for their tunable particle size, surface customization, and varied drug delivery capacities, are increasingly acknowledged in therapeutic applications. These vesicles exhibit surface flexibility, enabling the incorporation of targeting moieties or peptides to achieve specific targeting and avoid lysosomal entrapment. Internally, their adaptable architecture permits the inclusion of a broad spectrum of drugs, contingent on their solubility characteristics. This study thoroughly reviews liposome fabrication, surface modifications, and drug release mechanisms post-systemic administration, with a particular emphasis on drugs crossing the blood-brain barrier (BBB) to address lesions. Additionally, the review delves into recent developments in the use of liposomes in ischemic stroke models, offering a comparative evaluation with other nanocarriers like exosomes and nano-micelles, thereby facilitating their clinical advancement. Keywords: liposome, BBB, ischemic stroke, drug carrier, liposome-based engineering

Published
2024

36. Supplementary Table 1 and Materials and Methods from Targeting the Synthetic Vulnerability of PTEN-Deficient Glioblastoma Cells with MCL1 Inhibitors

Author

Chen, Chao, primary, Zhu, Sichao, primary, Zhang, Xia, primary, Zhou, Tingting, primary, Gu, Jing, primary, Xu, Yurong, primary, Wan, Quan, primary, Qi, Xiao, primary, Chai, Yezi, primary, Liu, Xiaorong, primary, Chen, Lukui, primary, Yan, Jie, primary, Hua, Yunfen, primary, and Lin, Fan, primary

Published
2023
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38. Hemimasticatory Spasm: Does Microvascular Decompression of Trigeminal Motor Root Work?

Author

Chen, Lukui, Wu, Guojian, Wang, Hong, Guo, Xiaoyuan, and Chitkara, Naveen

Subjects
Decompression (Physiology) -- Methods, Trigeminal nerve -- Health aspects, Blood vessels -- Surgery, Nervous system -- Surgery, Hemifacial spasm -- Care and treatment, Health
Abstract

Byline: Lukui. Chen, Guojian. Wu, Hong. Wang, Xiaoyuan. Guo, Naveen. Chitkara Hemimasticatory spasm (HMS) is a very rare disorder characterized by paroxysmal brief twitches or spasms of unilateral chewing muscles, [...]

Published
2021

39. Extracellular vesicles from medicated plasma of Buyang Huanwu decoction-preconditioned neural stem cells accelerate neurological recovery following ischemic stroke

Author

Long, Jun, primary, Gu, Chenyang, additional, Zhang, Qiankun, additional, Liu, Jiale, additional, Huang, Jiajun, additional, Li, Yajing, additional, Zhang, Yifan, additional, Li, Rong, additional, Ahmed, Waqas, additional, Zhang, Jianfeng, additional, Khan, Ahsan Ali, additional, Cai, Hengsen, additional, Hu, Yong, additional, and Chen, Lukui, additional

Published
2023
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45. Comparison of ketamine/xylazine and isoflurane anesthesia on the establishment of mouse middle cerebral artery occlusion model

Author

GU, Chenyang, primary, LIU, Jiale, additional, LI, Yajing, additional, ZHANG, Qiankun, additional, LIN, Chaoqun, additional, HUANG, Jiajun, additional, DUAN, Wenjie, additional, DENG, Yushu, additional, AHMED, Waqas, additional, LI, Rong, additional, LONG, Jun, additional, KHAN, Ahsan Ali, additional, and CHEN, Lukui, additional

Published
2022
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