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1. Neuromuscular and Metabolic Responses during Repeated Bouts of Loaded Downhill Walking

Author

Chalchat, Emeric, Siracusa, Julien, Peñailillo, Luis, Malgoyre, Alexandra, Bourrilhon, Cyprien, Charlot, Keyne, Martin, Vincent, and Garcia-Vicencio, Sebastian

Subjects
Quantitative Biology - Tissues and Organs
Abstract

The aim of this study was to compare vastus lateralis (VL) and rectus femoris (RF) muscles for their nervous and mechanical adaptations during two bouts of downhill walking (DW) with load carriage performed two weeks apart. Moreover, we investigated cardio-metabolic and perceived exertion responses during both DW bouts. Methods Seventeen participants performed two 45-min sessions of loaded DW (30% of body mass; slope: -25 %; speed: 4.5 km$\times$h -1 ) separated by two weeks. Rating of perceived exertion (RPE), cost of walking (C w ), heart rate (HR), and EMG activity of thigh muscles were assessed during the DW. Muscle shear elastic modulus ($\mu$) of RF and VL were assessed before each exercise bout. Maximal voluntary contraction (MVC) torque was assessed before (PRE), immediately after (POST), 24 and 48 h after the two exercise bouts. Results MVC torque decreased from POST (-23.7 $\pm$ 9.2%) to 48 h (-19.2 $\pm$ 11.9%) after the first exercise (Ex1), whereas it was significantly reduced only at POST (-14.6 $\pm$ 11.0%) after the second exercise (Ex2) (p < 0.001). RPE (Ex1: 12.3 $\pm$ 1.9; Ex2: 10.8 $\pm$ 2.0), HR (Ex1: 156 $\pm$ 23 bpm; Ex2: 145 $\pm$ 25 bpm), C w (Ex1: 4.5 $\pm$ 0.9 J$\times$m -1 $\times$kg -1 ; Ex2: 4.1 $\pm$ 0.7 J$\times$m -1 $\times$kg -1 ) and RF EMG activity (Ex1: 0.071 $\pm$ 0.028 mV; Ex2: 0.041 $\pm$ 0.014 mV) were significantly decreased during Ex2 compared to Ex1 (p < 0.01). RF $\mu$ was significantly greater in Ex2 (0.44 $\pm$ 0.18) compared to Ex1 (0.56 $\pm$ 0.27; p < 0.001). Conclusions The RF muscle displayed specific mechanical and nervous adaptations to repeated DW bouts as compared to VL. Moreover, the muscle adaptations conferred by the first bout of DW could have induced greater exercise efficiency, inducing lesser perceived exertion and cardio-metabolic demand when the same exercise was repeated two weeks later., Comment: Medicine and Science in Sports and Exercise, 2023

Published
2023
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2. Cognitive performance during exposure to moderate normobaric hypoxia after sleep restriction: Relationship to physiological and stress biomarkers

Author

Fabries, Pierre, Pontiggia, Anaïs, Comte, Ulysse, Beauchamps, Vincent, Quiquempoix, Michael, Guillard, Mathias, Ayounts, Haïk, Van Beers, Pascal, Drogou, Catherine, Touron, Julianne, Erkel, Marie-Claire, Gignoux-Huon, Françoise, Nespoulous, Olivier, Pinalie, Théo, Charlot, Keyne, Malgoyre, Alexandra, Sauvet, Fabien, Koulmann, Nathalie, Gomez-Merino, Danielle, and Chennaoui, Mounir

Published
2024
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8. Twenty four-hour passive heat and cold exposures did not modify energy intake and appetite but strongly modify food reward.

Author

Coca, Maxime, Besançon, Louis, Erblang, Mégane, Bourdon, Stéphanie, Gruel, Arnaud, Lepetit, Benoît, Beauchamps, Vincent, Tavard, Blandine, Oustric, Pauline, Finlayson, Graham S., Thivel, David, Malgoyre, Alexandra, Tardo-Dino, Pierre-Emmanuel, Bourrilhon, Cyprien, and Charlot, Keyne

Subjects
COLD (Temperature), REPEATED measures design, FOOD consumption, LEPTIN, DATA analysis, QUESTIONNAIRES, GLUCAGON-like peptide 1, FOOD security, APPETITE, PEPTIDE hormones, HUNGER, DESCRIPTIVE statistics, HEAT, REWARD (Psychology), LUNCHEONS, GHRELIN, FOOD habits, FRIEDMAN test (Statistics), ANALYSIS of variance, STATISTICS, FOOD preferences, COMPARATIVE studies, DATA analysis software, TIME, BREAKFASTS
Abstract

Effects of acute thermal exposures on appetite appear hypothetical in reason of very heterogeneous methodologies. The aim of this study was therefore to clearly define the effects of passive 24-h cold (16°C) and heat (32°C) exposures on appetitive responses compared with a thermoneutral condition (24°C). Twenty-three healthy, young and active male participants realised three sessions (from 13.00) in a laboratory conceived like an apartment dressed with the same outfit (Clo = 1). Three meals composed of three or four cold or warm dishes were served ad libitum to assess energy intake (EI). Leeds Food Preference Questionnaires were used before each meal to assess food reward. Subjective appetite was regularly assessed, and levels of appetitive hormones (acylated ghrelin, glucagon-like peptite-1, leptin and peptide YY) were assessed before and after the last meal (lunch). Contrary to the literature, total EI was not modified by cold or heat exposure (P = 0·120). Accordingly, hunger scores (P = 0·554) were not altered. Levels of acylated ghrelin and leptin were marginally higher during the 16 (P = 0·032) and 32°C (P < 0·023) sessions, respectively. Interestingly, implicit wanting for cold and low-fat foods at 32°C and for warm and high-fat foods at 16°C were increased during the whole exposure (P < 0·024). Moreover, cold entrées were more consumed at 32°C (P < 0·062) and warm main dishes more consumed at 16°C (P < 0·025). Thus, passive cold and hot exposures had limited effects on appetite, and it seems that offering some choice based on food temperature may help individuals to express their specific food preferences and maintain EI. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Weight regain, body composition, and metabolic responses to weight loss in weight cycling athletes: A systematic review and meta‐analyses.

Author

Bagot, Sarah, Pélissier, Léna, Pereira, Bruno, Chanséaume Bussiere, Emilie, Duclos, Martine, Dulloo, Abdul, Miles‐Chan, Jennifer, Charlot, Keyne, Boirie, Yves, Thivel, David, and Isacco, Laurie

Subjects
WEIGHT loss, BODY composition, BODY mass index, ADIPOSE tissues, BODY weight, ENDURANCE athletes
Abstract

Depending on the nature of their sports, athletes may be engaged in successive weight loss (WL) and regain, conducing to "weight cycling." The aims of this paper were to systematically (and meta‐analytically when possible) analyze the post‐WL recovery of (i) body weight and (ii) fat mass; fat‐free mass; and performance and metabolic responses in weight cycling athletes (18–55 years old, body mass index < 30 kg.m−2). MEDLINE, Embase, and SPORTDiscus databases were explored. The quality and risk of bias of the 74 included studies were assessed using the quality assessment tool for quantitative studies. Thirty‐two studies were eligible for meta‐analyses. Whatever the type of sports or methods used to lose weight, post‐WL body weight does not seem affected compared with pre‐WL. While similar results are observed for fat‐free mass, strength sports athletes (also having longer WL and regain periods) do not seem to fully recover their initial fat mass (ES: −0.39, 95% CI: [−0.77; −0.00], p = 0.048, I2 = 0.0%). Although the methods used by athletes to achieve WL might prevent them from a potential post‐WL fat overshooting, further studies are needed to better understand WL episodes consequences on athletes' performance as well as short‐ and long‐term physical, metabolic, and mental health. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Appropriateness of indirect markers of muscle damage following lower limbs eccentric-biased exercises: A systematic review with meta-analysis

Author

Chalchat, Emeric, primary, Gaston, Anne-Fleur, additional, Charlot, Keyne, additional, Peñailillo, Luis, additional, Valdés, Omar, additional, Tardo-Dino, Pierre-Emmanuel, additional, Nosaka, Kazunori, additional, Martin, Vincent, additional, Garcia-Vicencio, Sebastian, additional, and Siracusa, Julien, additional

Published
2022
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23. Appropriateness of indirect markers of muscle damage following lower limbs eccentric-biased exercises: A systematic review with meta-analysis

Author

Chalchat, Emeric, Gaston, Anne Fleur, Charlot, Keyne, Peñailillo, Luis, Valdés, Omar, Tardo-Dino, Pierre Emmanuel, Nosaka, Kazunori, Martin, Vincent, Garcia-Vicencio, Sebastian, Siracusa, Julien, Chalchat, Emeric, Gaston, Anne Fleur, Charlot, Keyne, Peñailillo, Luis, Valdés, Omar, Tardo-Dino, Pierre Emmanuel, Nosaka, Kazunori, Martin, Vincent, Garcia-Vicencio, Sebastian, and Siracusa, Julien

Abstract

Purpose The aim of this review was to (1) characterize the time-course of markers of exercise-induced muscle damage (EIMD) based on the level of maximal voluntary contraction torque loss at 24-48h post-exercise (MVCloss24-48h), (2) identify factors (e.g., exercise and population characteristics) affecting the level of MVCloss24-48h, and (3) evaluate the appropriateness of EIMD markers as indicators of MVCloss24-48h. Methods Magnitude of change of each EIMD markers was normalized using the standardized mean differences method to compare the results from different studies. Time-course of EIMD markers were characterized according to three levels of MVCloss24-48h based on a clustering analysis of the 141 studies included. Association between MVCloss24-48h levels and participant´s characteristics or exercise type/modalities were assessed. Meta-regressions were performed to investigate the associations between MVCloss24-48h and EIMD markers changes at <6h, 24h, 48h, 72h and > 96h after exercise. Results Time-course of EIMD markers recovery differs between levels of MVCloss24-48h. Training status and exercise type/modality were associated with MVCloss24-48h level (p < 0.05). MVCloss24-48h was correlated to changes in myoglobin concentration ( < 6h), jump height (24h) and range of motion (48h) (p < 0.001). Conclusion As the exercise could differently affect markers as function of the EIMD severity (i.e., MVCloss24-48h levels), different markers should be used as function of the timing of measurement. Mb concentration should be used during the first hours after the exercise ( < 6h), whereas jump height (24h) and range of motion (48h) could be used as surrogate for maximal voluntary contraction later. Moreover, training status and exercise type/modality could influence the magnitude of MVCloss24-48h

Published
2022

24. Exacerbation of oxidative stress during sickle vaso‐occlusive crisis is associated with decreased anti‐band 3 autoantibodies rate and increased red blood cell‐derived microparticle level: a prospective study

Author

Hierso, Régine, Lemonne, Nathalie, Villaescusa, Rinaldo, LalanneMistrih, MarieLaure, Charlot, Keyne, EtienneJulan, Maryse, Tressières, Benoit, Lamarre, Yann, Tarer, Vanessa, Garnier, Yohann, Hernandez, Ada Arce, Ferracci, Serge, Connes, Philippe, Romana, Marc, and HardyDessources, MarieDominique

Published
2017
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27. Retinal atrophy and markers of systemic and cerebrovascular severity in homozygous sickle cell disease

Author

Martin, Gilles C., primary, Brousse, Valentine, additional, Connes, Philippe, additional, Grevent, David, additional, Kossorotoff, Manoelle, additional, Da Costa, Lydie, additional, Bourdeau, Hélène, additional, Charlot, Keyne, additional, Boutonnat-Faucher, Bénédicte, additional, Allali, Slimane, additional, De Montalembert, Mariane, additional, Bremond-Gignac, Dominique, additional, Vidal, Pierre-Paul, additional, and Robert, Matthieu P., additional

Published
2022
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28. Repeated bout effect: Neuromuscular and cardiorespiratory responses during downhill walking in relation to muscle function loss

Author

Garcia-Vicencio, Sebastian, Chalchat, Emeric, Siracusa, Julien, Charlot, Keyne, Vincent, Martin, Institut de Recherche Biomédicale des Armées (IRBA), Laboratoire de Biologie de l'Exercice pour la Performance et la Santé (LBEPS), Université d'Évry-Val-d'Essonne (UEVE)-Université Paris-Saclay-Institut de Recherche Biomédicale des Armées (IRBA), Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne (UCA)-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Auvergne (UFR STAPS - UCA), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Martin, Vincent, Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), and Université d'Évry-Val-d'Essonne (UEVE)-Université Paris-Saclay-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA)

Subjects
exercise, [SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], muscle function, muscle architecture, eccentric exercise, load carriage, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], wave elastography, shear, induced muscle damage, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2021

29. Validity of the indirect biomarkers used in exercise-induced muscle damage: A systematic review with meta-analysis

Author

Chalchat, Emeric, Gaston, Anne fleur, Charlot, Keyne, Peñailillo, Luis, Valdès, Omar, Tardo-Dino, Pierre-Emmanuel, Nosaka, Kazunori, Vincent, Martin, Garcia-Vicencio, Sebastian, Siracusa, Julien, Institut de Recherche Biomédicale des Armées (IRBA), Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne (UCA)-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Auvergne (UFR STAPS - UCA), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), Laboratoire Européen Performance Santé Altitude (LEPSA), Université de Perpignan Via Domitia (UPVD), Laboratoire de Biologie de l'Exercice pour la Performance et la Santé (LBEPS), Université d'Évry-Val-d'Essonne (UEVE)-Université Paris-Saclay-Institut de Recherche Biomédicale des Armées (IRBA), Universidad Finis Terrae, Centre for Exercise and Sports Science Research, School of Medical and Health Sciences, Edith Cowan University, Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Martin, Vincent, Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), and Université d'Évry-Val-d'Essonne (UEVE)-Université Paris-Saclay-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA)

Subjects
[SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], creatine kinase, eccentric exercise, EIMD, myoglobin, rhabdomyolysis, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], DOMS, regression, meta, neuromuscular function, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2021

31. Physical activity level is not a determinant of autonomic nervous system activity and clinical severity in children/adolescents with sickle cell anemia: A pilot study

Author

Charlot, Keyne, Moeckesch, Berenike, Jumet, Stéphane, Romana, Marc, Waltz, Xavier, Divialle-Doumdo, Lydia, Hardy-Dessources, Marie-Dominique, Petras, Marie, Tressières, Benoît, Pichon, Aurélien, Tarer, Vanessa, Hue, Olivier, Etienne-Julan, Maryse, Antoine-Jonville, Sophie, and Connes, Philippe

Published
2015
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34. Circulating microRNAs after a 24‐h ultramarathon run in relation to muscle damage markers in elite athletes

Author

Chalchat, Emeric, primary, Charlot, Keyne, additional, Garcia‐Vicencio, Sebastian, additional, Hertert, Pierre, additional, Baugé, Stéphane, additional, Bourdon, Stéphanie, additional, Bompard, Julie, additional, Farges, Cédric, additional, Martin, Vincent, additional, Bourrilhon, Cyprien, additional, and Siracusa, Julien, additional

Published
2021
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36. Brain injury pathophysiology study by a multimodal approach in children with sickle cell anemia with no intra or extra cranial arteriopathy

Author

Brousse, Valentine, primary, Pondarre, Corinne, additional, Kossorotoff, Manoelle, additional, Arnaud, Cecile, additional, Kamdem, Annie, additional, de Montalembert, Mariane, additional, Boutonnat-Faucher, Benedicte, additional, Allali, Slimane, additional, Bourdeau, Hélène, additional, Charlot, Keyne, additional, Bertil, Sebastien, additional, Da Costa, Lydie, additional, Connes, Philippe, additional, Grévent, David, additional, and Verlhac, Suzanne, additional

Published
2021
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37. Loss of alpha globin genes is associated with improved microvascular function in patients with sickle cell anemia

Author

Romana, Marc, primary, Reminy, Karen, additional, Moeckesch, Berenike, additional, Charlot, Keyne, additional, Hardy‐Dessources, Marie‐Dominique, additional, Doumdo, Lydia, additional, Tressieres, Benoit, additional, Etienne‐Julan, Maryse, additional, Lemonne, Nathalie, additional, Denton, Christopher, additional, Coates, Thomas, additional, Petras, Marie, additional, Antoine‐Jonville, Sophie, additional, and Connes, Philippe, additional

Published
2021
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38. Circulating MicroRNAs : Biomarkers of muscle damage after a 24-hour ultramarathon run in elite athletes

Author

Chalchat, Emeric, Charlot, Keyne, Garcia-Vicencio, Sebastian, Hertert, Pierre, Bourdon, Stéphanie, Baugé, Stéphane, Dechambre, Julie, Farges, Cédric, Vincent, Martin, Bourrilhon, Cyprien, Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Auvergne (UFR STAPS - UCA), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Institut de Recherche Biomédicale des Armées (IRBA), Laboratoire de Biologie de l'Exercice pour la Performance et la Santé (LBEPS), Université d'Évry-Val-d'Essonne (UEVE)-Université Paris-Saclay-Institut de Recherche Biomédicale des Armées (IRBA), Fédération Française d'Athlétisme (FFA), Hôpital d'instruction des Armées Percy, Service de Santé des Armées, Centre hospitalier d'AlbiAlbi, France, Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), Université d'Évry-Val-d'Essonne (UEVE)-Université Paris-Saclay-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), and Chalchat, Emeric

Subjects
[SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2020

39. Brain injury pathophysiology study by a multimodal approach in children with sickle cell anemia with no intra or extra cranial arteriopathy

Author

Charlot, Keyne, Brousse, Valentine, Pondarre, Corinne, Kossorotoff, Manoelle, Arnaud, Cecile, Kamdem, Annie, Montalembert, Mariane De, Boutonnat-Faucher, Benedicte, Allali, Slimane, Bourdeau, Hélène, Ne Charlot, Key, Bertil, Sebastien, da Costa, Lydie, Connes, Philippe, Grévent, David, Verlhac, Suzanne, Laboratoire de Biologie de l'Exercice pour la Performance et la Santé (LBEPS), and Université d'Évry-Val-d'Essonne (UEVE)-Université Paris-Saclay-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA)

Subjects
medicine.medical_specialty, Adolescent, Anemia, Perfusion scanning, Anemia, Sickle Cell, Hemolysis, Endothelial activation, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Humans, Endothelial dysfunction, Child, business.industry, Hematology, Cerebral Infarction, medicine.disease, Magnetic Resonance Imaging, Sickle cell anemia, Decreased blood pressure, Brain Injuries, Cardiology, Complication, business, Perfusion, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, 030215 immunology
Abstract

Despite its high prevalence in children with sickle cell anemia (SCA), the pathophysiology of silent cerebral infarcts (SCI) remains elusive. The main objective of this study was to explore the respective roles of major determinants of brain perfusion in SCA children with no past or current history of intracranial or extracranial vasculopathy. We used a multimodal approach based notably on perfusion imaging arterial spin labeling (ASL) magnetic resonance imaging (MRI) and near infra-red spectroscopy (NIRS), as well as biomarkers reflecting blood rheology and endothelial activation. Out of 59 SCA patients (mean age 11.4±3.9 yrs), eight (13%) had a total of 12 SCI. Children with SCI had a distinctive profile characterized by decreased blood pressure, impaired blood rheology, increased P-selectin levels, and marked anemia. Although ASL perfusion and oximetry values did not differ between groups, comparison of biological and clinical parameters according to the level of perfusion categorized in terciles showed an independent association between high perfusion and increased sP-selectin, decreased red blood cell deformability, low hemoglobin F level, increased blood viscosity and no a-thalassemia deletion. NIRS measurements did not yield additional novel results. Altogether, these findings argue for early MRI detection of SCI in children with no identified vasculopathy and suggest a potential role for ASL as an additional screening tool. Early treatment targeting hemolysis, anemia and endothelial dysfunction should reduce the risk of this under diagnosed and serious complication.

Published
2020

44. One-Fifth of Children with Sickle Cell Anemia Show Exercise-Induced Hemoglobin Desaturation: Rate of Perceived Exertion and Role of Blood Rheology

Author

Brousse, Valentine, primary, Pondarre, Corinne, additional, Arnaud, Cecile, additional, Kamden, Annie, additional, de Montalembert, Mariane, additional, Boutonnat-Faucher, Benedicte, additional, Bourdeau, Hélène, additional, Charlot, Keyne, additional, Grévent, David, additional, Verlhac, Suzanne, additional, da Costa, Lydie, additional, and Connes, Philippe, additional

Published
2020
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45. Metabolic response to oral glucose tolerance test performed in neutral and warm environmental temperature

Author

Antoine-Jonville, Sophie, El Khoury, Dalia, Faure, Cécile, Charlot, Keyne, Hue, Olivier, Hardy-Dessources, Marie-Dominique, Adaptation, Climat Tropical, Exercice et Santé (ACTES), Université des Antilles (UA), Adaptations au Climat Tropical, Exercice et Santé (ACTES), Université des Antilles et de la Guyane (UAG), Biologie intégrée du globule rouge (BIGR), Université des Antilles et de la Guyane (UAG)-Institut National de la Transfusion Sanguine [Paris] (INTS)-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Guelph, Biologie Intégrée du Globule Rouge (BIGR (UMR_S_1134 / U1134)), Institut National de la Transfusion Sanguine [Paris] (INTS)-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles (UA), Antoine-Jonville, Sophie, Adaptation, Climat Tropical, Exercice et Santé [URp5_4] (ACTES), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles (UA)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Université de La Réunion (UR)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Transfusion Sanguine [Paris] (INTS), and Gros, Olivier

Subjects
[SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Adult, Male, lcsh:Medical technology, [SDV]Life Sciences [q-bio], Temperature, Administration, Oral, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Glucose Tolerance Test, oral glucose tolerance test, Young Adult, Metabolism, lcsh:R855-855.5, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Humans, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Female, glucoregulation, glucose, environment, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, ComputingMilieux_MISCELLANEOUS
Abstract

International audience; Objective: Hot environments are associated with impaired glucose metabolism at rest in healthy humans. The purpose of this study was to explore the contribution of key glucoregulatory hormones and biomarkers to this altered glucose tolerance. Methods: The effects of ambient temperature on glucose tolerance and its determinants were assessed with a 3-hr oral glucose tolerance test (OGTT) administered to 19 healthy young men and women at 22 °C and 31 °C. Results: The glucose response amplitude was greater in warm environment (AUC 904 ± 151 vs. 721 ± 89 mmol/l·180 min at 31 °C and 22 °C, respectively, p .17). The cortisol response to the glucose load was reduced 30, 60, 90 and 120 minutes postload at 31 °C compared with 22 °C (p = .001). The interleukin-6 concentration was also lower in the session at 31 °C (p = .043). Conclusion: We conclude that the effects of environmental temperature on the glucoregulatory hormones and biomarkers reported in this study do not explain the exaggerated increase in blood glucose after a glucose load taken in a warm environmental temperature. Precis statement: This work demonstrates in healthy men and women that the ingestion of glucose elicits an exaggerated increase in blood glucose when the environmental temperature is warm.

Published
2019

47. Proliferative retinopathy and maculopathy are two independent conditions in sickle cell disease: Is there a role of blood rheology?1

Author

Beral, Laurence, primary, Lemonne, Nathalie, additional, Romana, Marc, additional, Charlot, Keyne, additional, Billaud, Marie, additional, Acomat, Malik, additional, Zorobabel, Coralie, additional, Nader, Elie, additional, Etienne-Julan, Maryse, additional, David, Thierry, additional, and Connes, Philippe, additional

Published
2019
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