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Managing patients with treatment-resistant schizophrenia who do not respond adequately to Clozapine poses a challenge. Cariprazine, with its unique mechanism of action, may be an option for such patients. The additional benefits of using Cariprazine as an augmentation strategy include once-daily dosing, ease of titration, and a favourable side-effect profile. The report outlines the authors' experience of six patients with treatment-resistant schizophrenia who did not respond to Clozapine. The addition of Cariprazine was tolerated by all the patients. The majority showed improvement with symptom reduction, and in some cases, the dose of Clozapine could be reduced, thereby decreasing the side-effects of Clozapine. [ABSTRACT FROM AUTHOR]

This article discusses the use of Cariprazine, a third-generation antipsychotic, as an augmentation strategy in a patient with clozapine-resistant schizophrenia. The unique receptor profile of Cariprazine, including its partial agonist action at D2/D3 receptors and preferential binding to the D3 receptor, is believed to contribute to its advantages over other antipsychotics. The patient in the case study had previously tried multiple antipsychotics without success and experienced significant side effects from clozapine. After starting Cariprazine, the patient experienced improvement in symptoms and was able to reduce the dose of clozapine, resulting in a reduction in side effects. The article emphasizes the need for further research on the efficacy and long-term effects of Cariprazine as an augmentation strategy for patients who do not respond to clozapine. [Extracted from the article]

Allocating the right job to the right person is very essential to run a huge system. In the Indian Railways there are several drivers assigned to drive a train route each day for a fixed number of hours. This task can be allocated using the Hungarian method, but the proposed method can handle the load of an additional train route being added or even the shortage of a driver and assign the duty for the same number of drivers. The workload is distributed equally among all the drivers on different days. This new method can also be used to solve any assignment problems. [ABSTRACT FROM AUTHOR]