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1. Quantum Simulation of the Bosonic Kitaev Chain

Author

Busnaina, J. H., Shi, Z., McDonald, A., Dubyna, D., Nsanzineza, I., Hung, Jimmy S. C., Chang, C. W. Sandbo, Clerk, A. A., and Wilson, C. M.

Subjects
Quantum Physics, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

Superconducting quantum circuits are a natural platform for quantum simulations of a wide variety of important lattice models describing topological phenomena, spanning condensed matter and high-energy physics. One such model is the bosonic analogue of the well-known fermionic Kitaev chain, a 1D tight-binding model with both nearest-neighbor hopping and pairing terms. Despite being fully Hermitian, the bosonic Kitaev chain exhibits a number of striking features associated with non-Hermitian systems, including chiral transport and a dramatic sensitivity to boundary conditions known as the non-Hermitian skin effect. Here, using a multimode superconducting parametric cavity, we implement the bosonic Kitaev chain in synthetic dimensions. The lattice sites are mapped to frequency modes of the cavity, and the $\textit{in situ}$ tunable complex hopping and pairing terms are created by parametric pumping at the mode-difference and mode-sum frequencies, respectively. We experimentally demonstrate important precursors of nontrivial topology and the non-Hermitian skin effect in the bosonic Kitaev chain, including chiral transport, quadrature wavefunction localization, and sensitivity to boundary conditions. Our experiment is an important first step towards exploring genuine many-body non-Hermitian quantum dynamics.

Published
2023
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3. Quantum Simulation of the Bosonic Creutz Ladder with a Parametric Cavity

Author

Hung, Jimmy S. C., Busnaina, J. H., Chang, C. W. Sandbo, Vadiraj, A. M., Nsanzineza, I., Solano, E., Alaeian, H., Rico, E., and Wilson, C. M.

Subjects
Quantum Physics
Abstract

There has been a growing interest in realizing quantum simulators for physical systems where perturbative methods are ineffective. The scalability and flexibility of circuit quantum electrodynamics (cQED) make it a promising platform to implement various types of simulators, including lattice models of strongly-coupled field theories. Here, we use a multimode superconducting parametric cavity as a hardware-efficient analog quantum simulator, realizing a lattice in synthetic dimensions with complex hopping interactions. The coupling graph, \textit{i.e.} the realized model, can be programmed \textit{in situ}. The complex-valued hopping interaction further allows us to simulate, for instance, gauge potentials and topological models. As a demonstration, we simulate a plaquette of the bosonic Creutz ladder. We characterize the lattice with scattering measurements, reconstructing the experimental Hamiltonian and observing emerging topological features. This platform can be easily extended to larger lattices and different models involving other interactions., Comment: 10 pages, 3 figures

Published
2021
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4. Engineering the Level Structure of a Giant Artificial Atom in Waveguide Quantum Electrodynamics

Author

Vadiraj, A. M., Ask, Andreas, McConkey, T. G., Nsanzineza, I., Chang, C. W. Sandbo, Kockum, Anton Frisk, and Wilson, C. M.

Subjects
Quantum Physics, Condensed Matter - Superconductivity
Abstract

Engineering light-matter interactions at the quantum level has been central to the pursuit of quantum optics for decades. Traditionally, this has been done by coupling emitters, typically natural atoms and ions, to quantized electromagnetic fields in optical and microwave cavities. In these systems, the emitter is approximated as an idealized dipole, as its physical size is orders of magnitude smaller than the wavelength of light. Recently, artificial atoms made from superconducting circuits have enabled new frontiers in light-matter coupling, including the study of "giant" atoms which cannot be approximated as simple dipoles. Here, we explore a new implementation of a giant artificial atom, formed from a transmon qubit coupled to propagating microwaves at multiple points along an open transmission line. The nature of this coupling allows the qubit radiation field to interfere with itself leading to some striking giant-atom effects. For instance, we observe strong frequency-dependent couplings of the qubit energy levels to the electromagnetic modes of the transmission line. Combined with the ability to in situ tune the qubit energy levels, we show that we can modify the relative coupling rates of multiple qubit transitions by more than an order of magnitude. By doing so, we engineer a metastable excited state, allowing us to operate the giant transmon as an effective lambda system where we clearly demonstrate electromagnetically induced transparency., Comment: 12 pages, 8 figures

Published
2020
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5. Tripartite Genuine Non-Gaussian Entanglement in Three-Mode Spontaneous Parametric Downconversion

Author

Agustí, Andrés, Chang, C. W. Sandbo, Quijandría, Fernando, Johansson, Göran, Wilson, Christopher M., and Sabín, Carlos

Subjects
Quantum Physics
Abstract

We show that the states generated by a three-mode spontaneous parametric downconversion (SPDC) interaction Hamiltonian possess tripartite entanglement of a different nature to other paradigmatic three-mode entangled states generated by the combination of two-mode SPDCs interactions. While two-mode SPDC generates gaussian states whose entanglement can be characterized by standard criteria based on two-mode quantum correlations, these criteria fail to capture the entanglement generated by three-mode SPDC. We use criteria built from three-mode correlation functions to show that the class of states recently generated in a superconducting-circuit implementation of three-mode SPDC ideally have tripartite entanglement, contrary to recent claims in the literature. These criteria are suitable for triple SPDC but we show that they fail to detect tripartite entanglement in other states which are known to possess it, which illustrates the existence of two fundamentally different notions of tripartite entanglement in three-mode continuous variable systems., Comment: 5 pages and 4 figures

Published
2020
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6. Observation of Three-Photon Spontaneous Parametric Downconversion in a Superconducting Parametric Cavity

Author

Chang, C. W. Sandbo, Sabín, Carlos, Forn-Díaz, P., Quijandría, Fernando, Vadiraj, A. M., Nsanzineza, I., Johansson, G., and Wilson, C. M.

Subjects
Quantum Physics, Condensed Matter - Superconductivity
Abstract

Spontaneous parametric downconversion (SPDC) has been a key enabling technology in exploring quantum phenomena and their applications for decades. For instance, traditional SPDC, which splits a high energy pump photon into two lower energy photons, is a common way to produce entangled photon pairs. Since the early realizations of SPDC, researchers have thought to generalize it to higher order, e.g., to produce entangled photon triplets. However, directly generating photon triplets through a single SPDC process has remained elusive. Here, using a flux-pumped superconducting parametric cavity, we demonstrate direct three-photon SPDC, with photon triplets generated in a single cavity mode or split between multiple modes. With strong pumping, the states can be quite bright, with flux densities exceeding 60 photon/s/Hz. The observed states are strongly non-Gaussian, which has important implications for potential applications. In the single-mode case, we observe a triangular star-shaped distribution of quadrature voltages, indicative of the long-predicted "star state". The observed star state shows strong third-order correlations, as expected for a state generated by a cubic Hamiltonian. By pumping at the sum frequency of multiple modes, we observe strong three-body correlations between multiple modes, strikingly, in the absence of second-order correlations. We further analyze the third-order correlations under mode transformations by the symplectic symmetry group, showing that the observed transformation properties serve to "fingerprint" the specific cubic Hamiltonian that generates them. The observed non-Gaussian, third-order correlations represent an important step forward in quantum optics and may have a strong impact on quantum communication with microwave fields as well as continuous-variable quantum computation., Comment: 11 pages, 7 figures

Published
2019
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7. Receiver Operating Characteristics for a Prototype Quantum Two-Mode Squeezing Radar

Author

Luong, David, Chang, C. W. Sandbo, Vadiraj, A. M., Damini, Anthony, Wilson, C. M., and Balaji, Bhashyam

Subjects
Quantum Physics, Electrical Engineering and Systems Science - Signal Processing
Abstract

We have built and evaluated a prototype quantum radar, which we call a quantum two-mode squeezing radar (QTMS radar), in the laboratory. It operates solely at microwave frequencies; there is no downconversion from optical frequencies. Because the signal generation process relies on quantum mechanical principles, the system is considered to contain a quantum-enhanced radar transmitter. This transmitter generates a pair of entangled microwave signals and transmits one of them through free space, where the signal is measured using a simple and rudimentary receiver. At the heart of the transmitter is a device called a Josephson parametric amplifier (JPA), which generates a pair of entangled signals called two-mode squeezed vacuum (TMSV) at 6.1445 GHz and 7.5376 GHz. These are then sent through a chain of amplifiers. The 7.5376 GHz beam passes through 0.5 m of free space; the 6.1445 GHz signal is measured directly after amplification. The two measurement results are correlated in order to distinguish signal from noise. We compare our QTMS radar to a classical radar setup using conventional components, which we call a two-mode noise radar (TMN radar), and find that there is a significant gain when both systems broadcast signals at -82 dBm. This is shown via a comparison of receiver operator characteristic (ROC) curves. In particular, we find that the quantum radar requires 8 times fewer integrated samples compared to its classical counterpart to achieve the same performance., Comment: 17 pages, 17 figures; submitted to IEEE Transactions on Aerospace and Electronic Systems

Published
2019
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8. Quantum-Enhanced Noise Radar

Author

Chang, C. W. Sandbo, Vadiraj, A. M., Bourassa, J., Balaji, B., and Wilson, C. M.

Subjects
Quantum Physics
Abstract

We propose a novel protocol for quantum illumination: a quantum-enhanced noise radar. A two-mode squeezed state, which exhibits continuous-variable entanglement between so-called signal and idler beams, is used as input to the radar system. Compared to existing proposals for quantum illumination, our protocol does not require joint measurement of the signal and idler beams. This greatly enhances the practicality of the system by, for instance, eliminating the need for a quantum memory to store the idler. We perform a proof-of-principle experiment in the microwave regime, directly comparing the performance of a two-mode squeezed source to an ideal classical noise source that saturates the classical bound for correlation. We find that, even in the presence of significant added noise and loss, the quantum source outperforms the classical source by as much as an order of magnitude., Comment: 5 pages, 4 figures

Published
2018
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11. Generating Multimode Entangled Microwaves with a Superconducting Parametric Cavity

Author

Chang, C. W. Sandbo, Simoen, M., Aumentado, José, Sabín, Carlos, Forn-Díaz, P., Vadiraj, A. M., Quijandría, Fernando, Johansson, G., Fuentes, I., and Wilson, C. M.

Subjects
Quantum Physics
Abstract

In this Letter, we demonstrate the generation of multimode entangled states of propagating microwaves. The entangled states are generated by parametrically pumping a multimode superconducting cavity. By combining different pump frequencies, applied simultaneously to the device, we can produce different entanglement structures in a programable fashion. The Gaussian output states are fully characterized by measuring the full covariance matrices of the modes. The covariance matrices are absolutely calibrated using an in situ microwave calibration source, a shot noise tunnel junction. Applying a variety of entanglement measures, we demonstrate both full inseparability and genuine tripartite entanglement of the states. Our method is easily extensible to more modes., Comment: 5 pages, 1 figures, 1 table

Published
2017
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12. On-demand microwave generator of shaped single photons

Author

Forn-Díaz, P., Warren, C. W., Chang, C. W. S., Vadiraj, A. M., and Wilson, C. M.

Subjects
Quantum Physics, Condensed Matter - Superconductivity
Abstract

We demonstrate the full functionality of a circuit that generates single microwave photons on demand, with a wave packet that can be modulated with a near-arbitrary shape. We achieve such a high tunability by coupling a superconducting qubit near the end of a semi-infinite transmission line. A dc superconducting quantum interference device shunts the line to ground and is employed to modify the spatial dependence of the electromagnetic mode structure in the transmission line. This control allows us to couple and decouple the qubit from the line, shaping its emission rate on fast time scales. Our decoupling scheme is applicable to all types of superconducting qubits and other solid-state systems and can be generalized to multiple qubits as well as to resonators., Comment: 10 pages, 7 figures. Published version

Published
2017
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13. Intrinsic fluence non-uniformity in D3He backlit proton radiography.

Author

Johnson, T. M., Shan, J., Kishimori, R., Cufari, M. J., Adrian, P. J., Buschmann, B., Chang, C. W., Dannhoff, S. G., DeVault, A., Evans, T. E., Foo, B., Kunimune, J. H., Lawrence, Y., Pearcy, J. A., Reichelt, B. L., Russell, L., Sutcliffe, G. D., Vanderloo, N. L., Vargas, J., and Wink, C.

Subjects
NUCLEAR track detectors, PARTICLE physics, PHYSICS experiments, PROTONS, MAGNETIC fields
Abstract

Proton radiography is an essential diagnostic for studying magnetic fields in high energy density physics experiments. Protons are born in a fusion implosion, traverse the plasma, and are detected on CR-39 solid state nuclear track detectors. Here, it is shown that there is an intrinsic non-uniformity in ∼ 15 MeV D3He proton radiography data. The increasing angle between the proton trajectory and the center of the detector results in the proton traveling through more detector stack material. As the protons travel through more material and lose energy, the proton energy spectrum gets wider. Protons at the lower end of the spectrum can therefore be lost. The nominal filtering results in protons being ranged out at large angles, causing the intrinsic non-uniformity. This angular effect is confirmed with both OMEGA experiments and Geant4 simulations. It is found that reducing the filtering between the pieces of CR-39 in the detector stack mitigates this effect. Results from accelerator experiments show that this reduced filtering does not impact the detection efficiency of the CR-39. Accounting for this intrinsic fluence non-uniformity is essential for magnetic field reconstruction techniques using proton radiographs. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Characterization of a multimode coplanar waveguide parametric amplifier

Author

Simoen, M., Chang, C. W. S., Krantz, P., Bylander, Jonas, Wustmann, W., Shumeiko, V., Delsing, P., and Wilson, C. M.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

We characterize a novel Josephson parametric amplifier based on a flux-tunable quarter-wavelength resonator. The fundamental resonance frequency is ~1GHz, but we use higher modes of the resonator for our measurements. An on-chip tuning line allows for magnetic flux pumping of the amplifier. We investigate and compare degenerate parametric amplification, involving a single mode, and nondegenerate parametric amplification, using a pair of modes. We show that we reach quantum-limited noise performance in both cases, and we show that the added noise can be less than 0.5 added photons in the case of low gain.

Published
2014
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17. TR-SFX MmCPDII-DNA complex: 500 ns time-point collected in SACLA. Includes 500 ns, dark, and extrapolated structure factors

Author

Maestre-Reyna, M., primary, Wang, P.-H., additional, Nango, E., additional, Hosokawa, Y., additional, Saft, M., additional, Furrer, A., additional, Yang, C.-H., additional, Ngura Putu, E.P.G., additional, Wu, W.-J., additional, Emmerich, H.-J., additional, Engilberge, S., additional, Caramello, N., additional, Wranik, M., additional, Glover, H.L., additional, Franz-Badur, S., additional, Wu, H.-Y., additional, Lee, C.-C., additional, Huang, W.-C., additional, Huang, K.-F., additional, Chang, Y.-K., additional, Liao, J.-H., additional, Weng, J.-H., additional, Gad, W., additional, Chang, C.-W., additional, Pang, A.H., additional, Gashi, D., additional, Beale, E., additional, Ozerov, D., additional, Milne, C., additional, Cirelli, C., additional, Bacellar, C., additional, Sugahara, M., additional, Owada, S., additional, Joti, Y., additional, Yamashita, A., additional, Tanaka, R., additional, Tanaka, T., additional, Luo, F.J., additional, Tono, K., additional, Kiontke, S., additional, Spadaccini, R., additional, Royant, A., additional, Yamamoto, J., additional, Iwata, S., additional, Standfuss, J., additional, Essen, L.-O., additional, Bessho, Y., additional, and Tsai, M.-D., additional

Published
2023
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18. TR-SFX MmCPDII-DNA complex: 250 ps snapshot. Includes 250 ps, dark, and extrapolated structure factors

Author

Maestre-Reyna, M., primary, Wang, P.-H., additional, Nango, E., additional, Hosokawa, Y., additional, Saft, M., additional, Furrer, A., additional, Yang, C.-H., additional, Ngura Putu, E.P.G., additional, Wu, W.-J., additional, Emmerich, H.-J., additional, Engilberge, S., additional, Caramello, N., additional, Wranik, M., additional, Glover, H.L., additional, Franz-Badur, S., additional, Wu, H.-Y., additional, Lee, C.-C., additional, Huang, W.-C., additional, Huang, K.-F., additional, Chang, Y.-K., additional, Liao, J.-H., additional, Weng, J.-H., additional, Gad, W., additional, Chang, C.-W., additional, Pang, A.H., additional, Gashi, D., additional, Beale, E., additional, Ozerov, D., additional, Milne, C., additional, Cirelli, C., additional, Bacellar, C., additional, Sugahara, M., additional, Owada, S., additional, Joti, Y., additional, Yamashita, A., additional, Tanaka, R., additional, Tanaka, T., additional, Luo, F.J., additional, Tono, K., additional, Kiontke, S., additional, Spadaccini, R., additional, Royant, A., additional, Yamamoto, J., additional, Iwata, S., additional, Standfuss, J., additional, Essen, L.-O., additional, Bessho, Y., additional, and Tsai, M.-D., additional

Published
2023
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19. TR-SFX MmCPDII-DNA complex: 2 ns snapshot. Includes 2 ns, dark, and extrapolated structure factors

Author

Maestre-Reyna, M., primary, Wang, P.-H., additional, Nango, E., additional, Hosokawa, Y., additional, Saft, M., additional, Furrer, A., additional, Yang, C.-H., additional, Ngura Putu, E.P.G., additional, Wu, W.-J., additional, Emmerich, H.-J., additional, Engilberge, S., additional, Caramello, N., additional, Wranik, M., additional, Glover, H.L., additional, Franz-Badur, S., additional, Wu, H.-Y., additional, Lee, C.-C., additional, Huang, W.-C., additional, Huang, K.-F., additional, Chang, Y.-K., additional, Liao, J.-H., additional, Weng, J.-H., additional, Gad, W., additional, Chang, C.-W., additional, Pang, A.H., additional, Gashi, D., additional, Beale, E., additional, Ozerov, D., additional, Milne, C., additional, Cirelli, C., additional, Bacellar, C., additional, Sugahara, M., additional, Owada, S., additional, Joti, Y., additional, Yamashita, A., additional, Tanaka, R., additional, Tanaka, T., additional, Luo, F.J., additional, Tono, K., additional, Kiontke, S., additional, Spadaccini, R., additional, Royant, A., additional, Yamamoto, J., additional, Iwata, S., additional, Standfuss, J., additional, Essen, L.-O., additional, Bessho, Y., additional, and Tsai, M.-D., additional

Published
2023
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20. TR-SFX MmCPDII-DNA complex: 100 ps snapshot. Includes 100ps, dark, and extrapolated structure factors

Author

Maestre-Reyna, M., primary, Wang, P.-H., additional, Nango, E., additional, Hosokawa, Y., additional, Saft, M., additional, Furrer, A., additional, Yang, C.-H., additional, Ngura Putu, E.P.G., additional, Wu, W.-J., additional, Emmerich, H.-J., additional, Engilberge, S., additional, Caramello, N., additional, Wranik, M., additional, Glover, H.L., additional, Franz-Badur, S., additional, Wu, H.-Y., additional, Lee, C.-C., additional, Huang, W.-C., additional, Huang, K.-F., additional, Chang, Y.-K., additional, Liao, J.-H., additional, Weng, J.-H., additional, Gad, W., additional, Chang, C.-W., additional, Pang, A.H., additional, Gashi, D., additional, Beale, E., additional, Ozerov, D., additional, Milne, C., additional, Cirelli, C., additional, Bacellar, C., additional, Sugahara, M., additional, Owada, S., additional, Joti, Y., additional, Yamashita, A., additional, Tanaka, R., additional, Tanaka, T., additional, Luo, F.J., additional, Tono, K., additional, Kiontke, S., additional, Spadaccini, R., additional, Royant, A., additional, Yamamoto, J., additional, Iwata, S., additional, Standfuss, J., additional, Essen, L.-O., additional, Bessho, Y., additional, and Tsai, M.-D., additional

Published
2023
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21. TR-SFX MmCPDII-DNA complex: 10 ns time-point collected in SACLA. Includes 10 ns, dark, and extrapolated structure factors

Author

Maestre-Reyna, M., primary, Wang, P.-H., additional, Nango, E., additional, Hosokawa, Y., additional, Saft, M., additional, Furrer, A., additional, Yang, C.-H., additional, Ngura Putu, E.P.G., additional, Wu, W.-J., additional, Emmerich, H.-J., additional, Engilberge, S., additional, Caramello, N., additional, Wranik, M., additional, Glover, H.L., additional, Franz-Badur, S., additional, Wu, H.-Y., additional, Lee, C.-C., additional, Huang, W.-C., additional, Huang, K.-F., additional, Chang, Y.-K., additional, Liao, J.-H., additional, Weng, J.-H., additional, Gad, W., additional, Chang, C.-W., additional, Pang, A.H., additional, Gashi, D., additional, Beale, E., additional, Ozerov, D., additional, Milne, C., additional, Cirelli, C., additional, Bacellar, C., additional, Sugahara, M., additional, Owada, S., additional, Joti, Y., additional, Yamashita, A., additional, Tanaka, R., additional, Tanaka, T., additional, Luo, F.J., additional, Tono, K., additional, Kiontke, S., additional, Spadaccini, R., additional, Royant, A., additional, Yamamoto, J., additional, Iwata, S., additional, Standfuss, J., additional, Essen, L.-O., additional, Bessho, Y., additional, and Tsai, M.-D., additional

Published
2023
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22. TR-SFX MmCPDII-DNA complex: 25 us time-point collected in SACLA. Includes 25 us, dark, and extrapolated structure factors

Author

Maestre-Reyna, M., primary, Wang, P.-H., additional, Nango, E., additional, Hosokawa, Y., additional, Saft, M., additional, Furrer, A., additional, Yang, C.-H., additional, Ngura Putu, E.P.G., additional, Wu, W.-J., additional, Emmerich, H.-J., additional, Engilberge, S., additional, Caramello, N., additional, Wranik, M., additional, Glover, H.L., additional, Franz-Badur, S., additional, Wu, H.-Y., additional, Lee, C.-C., additional, Huang, W.-C., additional, Huang, K.-F., additional, Chang, Y.-K., additional, Liao, J.-H., additional, Weng, J.-H., additional, Gad, W., additional, Chang, C.-W., additional, Pang, A.H., additional, Gashi, D., additional, Beale, E., additional, Ozerov, D., additional, Milne, C., additional, Cirelli, C., additional, Bacellar, C., additional, Sugahara, M., additional, Owada, S., additional, Joti, Y., additional, Yamashita, A., additional, Tanaka, R., additional, Tanaka, T., additional, Luo, F.J., additional, Tono, K., additional, Kiontke, S., additional, Spadaccini, R., additional, Royant, A., additional, Yamamoto, J., additional, Iwata, S., additional, Standfuss, J., additional, Essen, L.-O., additional, Bessho, Y., additional, and Tsai, M.-D., additional

Published
2023
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23. TR-SFX MmCPDII-DNA complex: 3.35 ns snapshot. Includes 3.35 ns, dark, and extrapolated structure factors

Author

Maestre-Reyna, M., primary, Wang, P.-H., additional, Nango, E., additional, Hosokawa, Y., additional, Saft, M., additional, Furrer, A., additional, Yang, C.-H., additional, Ngura Putu, E.P.G., additional, Wu, W.-J., additional, Emmerich, H.-J., additional, Engilberge, S., additional, Caramello, N., additional, Wranik, M., additional, Glover, H.L., additional, Franz-Badur, S., additional, Wu, H.-Y., additional, Lee, C.-C., additional, Huang, W.-C., additional, Huang, K.-F., additional, Chang, Y.-K., additional, Liao, J.-H., additional, Weng, J.-H., additional, Gad, W., additional, Chang, C.-W., additional, Pang, A.H., additional, Gashi, D., additional, Beale, E., additional, Ozerov, D., additional, Milne, C., additional, Cirelli, C., additional, Bacellar, C., additional, Sugahara, M., additional, Owada, S., additional, Joti, Y., additional, Yamashita, A., additional, Tanaka, R., additional, Tanaka, T., additional, Luo, F.J., additional, Tono, K., additional, Kiontke, S., additional, Spadaccini, R., additional, Royant, A., additional, Yamamoto, J., additional, Iwata, S., additional, Standfuss, J., additional, Essen, L.-O., additional, Bessho, Y., additional, and Tsai, M.-D., additional

Published
2023
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24. TR-SFX MmCPDII-DNA complex: dark state as collected in SACLA

Author

Maestre-Reyna, M., primary, Wang, P.-H., additional, Nango, E., additional, Hosokawa, Y., additional, Saft, M., additional, Furrer, A., additional, Yang, C.-H., additional, Ngura Putu, E.P.G., additional, Wu, W.-J., additional, Emmerich, H.-J., additional, Engilberge, S., additional, Caramello, N., additional, Wranik, M., additional, Glover, H.L., additional, Franz-Badur, S., additional, Wu, H.-Y., additional, Lee, C.-C., additional, Huang, W.-C., additional, Huang, K.-F., additional, Chang, Y.-K., additional, Liao, J.-H., additional, Weng, J.-H., additional, Gad, W., additional, Chang, C.-W., additional, Pang, A.H., additional, Gashi, D., additional, Beale, E., additional, Ozerov, D., additional, Milne, C., additional, Cirelli, C., additional, Bacellar, C., additional, Sugahara, M., additional, Owada, S., additional, Joti, Y., additional, Yamashita, A., additional, Tanaka, R., additional, Tanaka, T., additional, Luo, F.J., additional, Tono, K., additional, Kiontke, S., additional, Spadaccini, R., additional, Royant, A., additional, Yamamoto, J., additional, Iwata, S., additional, Standfuss, J., additional, Essen, L.-O., additional, Bessho, Y., additional, and Tsai, M.-D., additional

Published
2023
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25. Dark, fully reduced structure of the MmCPDII-DNA complex as produced at SwissFEL

Author

Maestre-Reyna, M., primary, Wang, P.-H., additional, Nango, E., additional, Hosokawa, Y., additional, Saft, M., additional, Furrer, A., additional, Yang, C.-H., additional, Ngura Putu, E.P.G., additional, Wu, W.-J., additional, Emmerich, H.-J., additional, Engilberge, S., additional, Caramello, N., additional, Wranik, M., additional, Glover, H.L., additional, Franz-Badur, S., additional, Wu, H.-Y., additional, Lee, C.-C., additional, Huang, W.-C., additional, Huang, K.-F., additional, Chang, Y.-K., additional, Liao, J.-H., additional, Weng, J.-H., additional, Gad, W., additional, Chang, C.-W., additional, Pang, A.H., additional, Gashi, D., additional, Beale, E., additional, Ozerov, D., additional, Milne, C., additional, Cirelli, C., additional, Bacellar, C., additional, Sugahara, M., additional, Owada, S., additional, Joti, Y., additional, Yamashita, A., additional, Tanaka, R., additional, Tanaka, T., additional, Luo, F.J., additional, Tono, K., additional, Kiontke, S., additional, Spadaccini, R., additional, Royant, A., additional, Yamamoto, J., additional, Iwata, S., additional, Standfuss, J., additional, Essen, L.-O., additional, Bessho, Y., additional, and Tsai, M.-D., additional

Published
2023
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26. DF-SFX MmCPDII-DNA complex: steady state oxidized complex

Author

Maestre-Reyna, M., primary, Wang, P.-H., additional, Nango, E., additional, Hosokawa, Y., additional, Saft, M., additional, Furrer, A., additional, Yang, C.-H., additional, Ngura Putu, E.P.G., additional, Wu, W.-J., additional, Emmerich, H.-J., additional, Engilberge, S., additional, Caramello, N., additional, Wranik, M., additional, Glover, H.L., additional, Franz-Badur, S., additional, Wu, H.-Y., additional, Lee, C.-C., additional, Huang, W.-C., additional, Huang, K.-F., additional, Chang, Y.-K., additional, Liao, J.-H., additional, Weng, J.-H., additional, Gad, W., additional, Chang, C.-W., additional, Pang, A.H., additional, Gashi, D., additional, Beale, E., additional, Ozerov, D., additional, Milne, C., additional, Cirelli, C., additional, Bacellar, C., additional, Sugahara, M., additional, Owada, S., additional, Joti, Y., additional, Yamashita, A., additional, Tanaka, R., additional, Tanaka, T., additional, Luo, F.J., additional, Tono, K., additional, Kiontke, S., additional, Spadaccini, R., additional, Royant, A., additional, Yamamoto, J., additional, Iwata, S., additional, Standfuss, J., additional, Essen, L.-O., additional, Bessho, Y., additional, and Tsai, M.-D., additional

Published
2023
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27. TR-SFX MmCPDII-DNA complex: 6 ns snapshot. Includes 6 ns, dark, and extrapolated structure factors

Author

Maestre-Reyna, M., primary, Wang, P.-H., additional, Nango, E., additional, Hosokawa, Y., additional, Saft, M., additional, Furrer, A., additional, Yang, C.-H., additional, Ngura Putu, E.P.G., additional, Wu, W.-J., additional, Emmerich, H.-J., additional, Engilberge, S., additional, Caramello, N., additional, Wranik, M., additional, Glover, H.L., additional, Franz-Badur, S., additional, Wu, H.-Y., additional, Lee, C.-C., additional, Huang, W.-C., additional, Huang, K.-F., additional, Chang, Y.-K., additional, Liao, J.-H., additional, Weng, J.-H., additional, Gad, W., additional, Chang, C.-W., additional, Pang, A.H., additional, Gashi, D., additional, Beale, E., additional, Ozerov, D., additional, Milne, C., additional, Cirelli, C., additional, Bacellar, C., additional, Sugahara, M., additional, Owada, S., additional, Joti, Y., additional, Yamashita, A., additional, Tanaka, R., additional, Tanaka, T., additional, Luo, F.J., additional, Tono, K., additional, Kiontke, S., additional, Spadaccini, R., additional, Royant, A., additional, Yamamoto, J., additional, Iwata, S., additional, Standfuss, J., additional, Essen, L.-O., additional, Bessho, Y., additional, and Tsai, M.-D., additional

Published
2023
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28. TR-SFX MmCPDII-DNA complex: 650 ps snapshot. Includes 650ps, dark, and extrapolated structure factors

Author

Maestre-Reyna, M., primary, Wang, P.-H., additional, Nango, E., additional, Hosokawa, Y., additional, Saft, M., additional, Furrer, A., additional, Yang, C.-H., additional, Ngura Putu, E.P.G., additional, Wu, W.-J., additional, Emmerich, H.-J., additional, Engilberge, S., additional, Caramello, N., additional, Wranik, M., additional, Glover, H.L., additional, Franz-Badur, S., additional, Wu, H.-Y., additional, Lee, C.-C., additional, Huang, W.-C., additional, Huang, K.-F., additional, Chang, Y.-K., additional, Liao, J.-H., additional, Weng, J.-H., additional, Gad, W., additional, Chang, C.-W., additional, Pang, A.H., additional, Gashi, D., additional, Beale, E., additional, Ozerov, D., additional, Milne, C., additional, Cirelli, C., additional, Bacellar, C., additional, Sugahara, M., additional, Owada, S., additional, Joti, Y., additional, Yamashita, A., additional, Tanaka, R., additional, Tanaka, T., additional, Luo, F.J., additional, Tono, K., additional, Kiontke, S., additional, Spadaccini, R., additional, Royant, A., additional, Yamamoto, J., additional, Iwata, S., additional, Standfuss, J., additional, Essen, L.-O., additional, Bessho, Y., additional, and Tsai, M.-D., additional

Published
2023
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29. TR-SFX MmCPDII-DNA complex: 450 ps snapshot. Includes 450ps, dark, and extrapolated structure factors

Author

Maestre-Reyna, M., primary, Wang, P.-H., additional, Nango, E., additional, Hosokawa, Y., additional, Saft, M., additional, Furrer, A., additional, Yang, C.-H., additional, Ngura Putu, E.P.G., additional, Wu, W.-J., additional, Emmerich, H.-J., additional, Engilberge, S., additional, Caramello, N., additional, Wranik, M., additional, Glover, H.L., additional, Franz-Badur, S., additional, Wu, H.-Y., additional, Lee, C.-C., additional, Huang, W.-C., additional, Huang, K.-F., additional, Chang, Y.-K., additional, Liao, J.-H., additional, Weng, J.-H., additional, Gad, W., additional, Chang, C.-W., additional, Pang, A.H., additional, Gashi, D., additional, Beale, E., additional, Ozerov, D., additional, Milne, C., additional, Cirelli, C., additional, Bacellar, C., additional, Sugahara, M., additional, Owada, S., additional, Joti, Y., additional, Yamashita, A., additional, Tanaka, R., additional, Tanaka, T., additional, Luo, F.J., additional, Tono, K., additional, Kiontke, S., additional, Spadaccini, R., additional, Royant, A., additional, Yamamoto, J., additional, Iwata, S., additional, Standfuss, J., additional, Essen, L.-O., additional, Bessho, Y., additional, and Tsai, M.-D., additional

Published
2023
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30. TR-SFX MmCPDII-DNA complex: 10 ns snapshot. Includes 10 ns, dark, and extrapolated structure factors. Collected at SwissFEL

Author

Maestre-Reyna, M., primary, Wang, P.-H., additional, Nango, E., additional, Hosokawa, Y., additional, Saft, M., additional, Furrer, A., additional, Yang, C.-H., additional, Ngura Putu, E.P.G., additional, Wu, W.-J., additional, Emmerich, H.-J., additional, Engilberge, S., additional, Caramello, N., additional, Wranik, M., additional, Glover, H.L., additional, Franz-Badur, S., additional, Wu, H.-Y., additional, Lee, C.-C., additional, Huang, W.-C., additional, Huang, K.-F., additional, Chang, Y.-K., additional, Liao, J.-H., additional, Weng, J.-H., additional, Gad, W., additional, Chang, C.-W., additional, Pang, A.H., additional, Gashi, D., additional, Beale, E., additional, Ozerov, D., additional, Milne, C., additional, Cirelli, C., additional, Bacellar, C., additional, Sugahara, M., additional, Owada, S., additional, Joti, Y., additional, Yamashita, A., additional, Tanaka, R., additional, Tanaka, T., additional, Luo, F.J., additional, Tono, K., additional, Kiontke, S., additional, Spadaccini, R., additional, Royant, A., additional, Yamamoto, J., additional, Iwata, S., additional, Standfuss, J., additional, Essen, L.-O., additional, Bessho, Y., additional, and Tsai, M.-D., additional

Published
2023
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31. TR-SFX MmCPDII-DNA complex: 1 ns snapshot. Includes 1 ns, dark, and extrapolated structure factors

Author

Maestre-Reyna, M., primary, Wang, P.-H., additional, Nango, E., additional, Hosokawa, Y., additional, Saft, M., additional, Furrer, A., additional, Yang, C.-H., additional, Ngura Putu, E.P.G., additional, Wu, W.-J., additional, Emmerich, H.-J., additional, Engilberge, S., additional, Caramello, N., additional, Wranik, M., additional, Glover, H.L., additional, Franz-Badur, S., additional, Wu, H.-Y., additional, Lee, C.-C., additional, Huang, W.-C., additional, Huang, K.-F., additional, Chang, Y.-K., additional, Liao, J.-H., additional, Weng, J.-H., additional, Gad, W., additional, Chang, C.-W., additional, Pang, A.H., additional, Gashi, D., additional, Beale, E., additional, Ozerov, D., additional, Milne, C., additional, Cirelli, C., additional, Bacellar, C., additional, Sugahara, M., additional, Owada, S., additional, Joti, Y., additional, Yamashita, A., additional, Tanaka, R., additional, Tanaka, T., additional, Luo, F.J., additional, Tono, K., additional, Kiontke, S., additional, Spadaccini, R., additional, Royant, A., additional, Yamamoto, J., additional, Iwata, S., additional, Standfuss, J., additional, Essen, L.-O., additional, Bessho, Y., additional, and Tsai, M.-D., additional

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2023
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32. MmCPDII-DNA complex containing low-dosage, light induced repaired DNA.

Author

Maestre-Reyna, M., primary, Wang, P.-H., additional, Nango, E., additional, Hosokawa, Y., additional, Saft, M., additional, Furrer, A., additional, Yang, C.-H., additional, Ngura Putu, E.P.G., additional, Wu, W.-J., additional, Emmerich, H.-J., additional, Engilberge, S., additional, Caramello, N., additional, Wranik, M., additional, Glover, H.L., additional, Franz-Badur, S., additional, Wu, H.-Y., additional, Lee, C.-C., additional, Huang, W.-C., additional, Huang, K.-F., additional, Chang, Y.-K., additional, Liao, J.-H., additional, Weng, J.-H., additional, Gad, W., additional, Chang, C.-W., additional, Pang, A.H., additional, Gashi, D., additional, Beale, E., additional, Ozerov, D., additional, Milne, C., additional, Cirelli, C., additional, Bacellar, C., additional, Sugahara, M., additional, Owada, S., additional, Joti, Y., additional, Yamashita, A., additional, Tanaka, R., additional, Tanaka, T., additional, Luo, F.J., additional, Tono, K., additional, Kiontke, S., additional, Spadaccini, R., additional, Royant, A., additional, Yamamoto, J., additional, Iwata, S., additional, Standfuss, J., additional, Essen, L.-O., additional, Bessho, Y., additional, and Tsai, M.-D., additional

Published
2023
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34. A Mira-GFP screen : looking for missing genes in bicoid mRNA localisation

Author

Chang, C-W.

Subjects
591.35
Abstract

During Drosophila oogenesis, bicoid mRNA is localised to the anterior of the oocyte, where it is translated after egg deposition to pattern the head. However, only a few genes involved in the bcd mRNA localisation have been identified in classic genetic screens. In this thesis, I describe a genetic screen for suppressors of Miranda-GFP, which was designed to identify missing genes required for the bcd mRNA localisation. Mira is not endogenously expressed during oogenesis. However, when Mira-GFP is expressed in the female germ line, the resulting embryos show a maternal-effect lethal bicaudal phenotype. oskar mRNA is localised to both anterior and posterior ends of these embryos and co-localises with Staufen to both ends of the oocyte. Stau is double-strand RNA binding protein and is required for osk and bcd mRNA localisation during oogenesis and asymmetrical prospero mRNA localisation in neuroblasts. Mira functions as an adaptor to couple Stau/pros mRNA to the basal side of neuroblasts. Mutants in genes required for bcd mRNA localisation, such as exuperantia and swallow, suppress the Mira-GFP bicaudal phenotype. Osk mRNA diffuses from the anterior of these oocytes in a similar way to bcd mRNA, indicating that Mira-GFP couples Stau/osk mRNA to the anterior localisation pathway. I further confirmed this by showing that the anterior localisation of Mira-GFP is microtubule-dependent, like bcd mRNA. In order to find genes required for bcd mRNA localisation, I performed a screen for dominant suppressors of the Mira-GFP bicaudal phenotype. I have identified and characterised a number of interesting mutants from this screen, and have shown that several of them cause defects in bcd mRNA localisation.

Published
2007

40. First Demonstration of Heterogeneous L-shaped Field Effect Transistor (LFET) for Angstrom Technology Nodes

Author

Yang, C.-Y., primary, Sung, P.-J., additional, Chuang, M.-H., additional, Chang, C.-W., additional, Shih, Y.-J., additional, Huang, T.-Y., additional, Lu, D. D., additional, Hong, T.-C., additional, Yu, X.-R., additional, Lu, W.-H., additional, Chang, S.-W., additional, Tsai, J.-J., additional, Huang, M.-K., additional, Cho, T.-C., additional, Lee, Y.-J., additional, Luo, K.-L., additional, Wu, C.-T., additional, Su, C.-J., additional, Kao, K.-H., additional, Chao, T.-S., additional, Wu, W.-F., additional, and Wang, Y.-H., additional

Published
2022
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41. Prediction of plan adaptation in head and neck cancer proton therapy using clinical, radiographic, and dosimetric features

Author

Bohannon, D., Janopaul-Naylor, J., Rudra, S., Yang, X., Chang, C. W., Wang, Y., Ma, C., Patel, S. A., McDonald, M. W., and Zhou, J.

Abstract

Because proton head and neck (HN) treatments are sensitive to anatomical changes, plan adaptation (re-plan) during the treatment course is needed for a significant portion of patients. We aim to predict re-plan at plan review stage for HN proton therapy with a neural network (NN) model trained with patients’ dosimetric and clinical features. The model can serve as a valuable tool for planners to assess the probability of needing to revise the current plan. Mean beam dose heterogeneity index (BHI), defined as the ratio of the maximum beam dose to the prescription dose, plan robustness features (clinical target volume (CTV), V100 changes, and V100 > 95% passing rates in 21 robust evaluation scenarios), as well as clinical features (e.g., age, tumor site, and surgery/chemotherapy status) were gathered from 171 patients treated at our proton center in 2020, with a median age of 64 and stages from I-IVc across 13 HN sites. Statistical analyses of dosimetric parameters and clinical features were conducted between re-plan and no-replan groups. A NN was trained and tested using these features. Receiver operating characteristic (ROC) analysis was conducted to evaluate the performance of the prediction model. A sensitivity analysis was done to determine feature importance. Mean BHI in the re-plan group was significantly higher than the no-replan group (p < .01). Tumor site (p < .01), chemotherapy status (p < .01), and surgery status (p < .01) were significantly correlated to re-plan. The model had sensitivities/specificities of 75.0%/77.4%, respectively, and an area under the ROC curve of .855. There are several dosimetric and clinical features that correlate to re-plans, and NNs trained with these features can be used to predict HN re-plans, which can be used to reduce re-plan rate by improving plan quality.

Published
2023
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49. VERONICA: Randomized Phase II Study of Fulvestrant and Venetoclax in ER-Positive Metastatic Breast Cancer Post-CDK4/6 Inhibitors - Efficacy, Safety, and Biomarker Results

Author

Lindeman, GJ, Fernando, TM, Bowen, R, Jerzak, KJ, Song, X, Decker, T, Boyle, F, McCune, S, Armstrong, A, Shannon, C, Bertelli, G, Chang, C-W, Desai, R, Gupta, K, Wilson, TR, Flechais, A, Bardia, A, Lindeman, GJ, Fernando, TM, Bowen, R, Jerzak, KJ, Song, X, Decker, T, Boyle, F, McCune, S, Armstrong, A, Shannon, C, Bertelli, G, Chang, C-W, Desai, R, Gupta, K, Wilson, TR, Flechais, A, and Bardia, A

Abstract

PURPOSE: Despite promising activity in hematopoietic malignancies, efficacy of the B-cell lymphoma 2 (BCL2) inhibitor venetoclax in solid tumors is unknown. We report the prespecified VERONICA primary results, a randomized phase II clinical trial evaluating venetoclax and fulvestrant in estrogen receptor (ER)-positive, HER2-negative metastatic breast cancer, post-cyclin-dependent kinase (CDK) 4/6 inhibitor progression. PATIENTS AND METHODS: Pre-/postmenopausal females ≥18 years were randomized 1:1 to venetoclax (800 mg orally daily) plus fulvestrant (500 mg intramuscular; cycle 1: days 1 and 15; subsequent 28-day cycles: day 1) or fulvestrant alone. The primary endpoint was clinical benefit rate (CBR); secondary endpoints were progression-free survival (PFS), overall survival, and safety. Exploratory biomarker analyses included BCL2 and BCL extra-large (BCLXL) tumor expression, and PIK3CA circulating tumor DNA mutational status. RESULTS: At primary analysis (cutoff: August 5, 2020; n = 103), venetoclax did not significantly improve CBR [venetoclax plus fulvestrant: 11.8% (n = 6/51; 95% confidence interval (CI), 4.44-23.87); fulvestrant: 13.7% (7/51; 5.70-26.26); risk difference -1.96% (95% CI, -16.86 to 12.94)]. Median PFS was 2.69 months (95% CI, 1.94-3.71) with venetoclax plus fulvestrant versus 1.94 months (1.84-3.55) with fulvestrant (stratified HR, 0.94; 95% CI, 0.61-1.45; P = 0.7853). Overall survival data were not mature. A nonsignificant improvement of CBR and PFS was observed in patients whose tumors had strong BCL2 expression (IHC 3+), a BCL2/BCLXL Histoscore ratio ≥1, or PIK3CA-wild-type status. CONCLUSIONS: Our findings do not indicate clinical utility for venetoclax plus fulvestrant in endocrine therapy-resistant, CDK4/6 inhibitor-refractory metastatic breast tumors, but suggest possible increased dependence on BCLXL in this setting.

Published
2022

50. Temporal associations between problematic use of the internet and self-stigma among people with substance use disorders : A cross-lagged model across one year

Author

Chen, I. -H, Chang, K. -C, Chang, C. -W, Huang, S. -W, Potenza, M. N., Pakpour, Amir H., Lin, C. -Y, Chen, I. -H, Chang, K. -C, Chang, C. -W, Huang, S. -W, Potenza, M. N., Pakpour, Amir H., and Lin, C. -Y

Abstract

Self-stigma is a common experience for people with substance use disorders (SUDs). Understanding factors associated with self-stigma may aid in intervention development. This study investigated the reciprocal relationship between three types of problematic use of the internet [PUI; i.e. problematic use of social media (PUSM), problematic smartphone use (PSPU), and problematic gaming (PG)] and self-stigma among people with SUDs. This longitudinal study involved five waves of a survey given to individuals with SUDs in Taiwan. A total of 319 participants (85% male), with a mean age of 42.2 years (SD = 8.9), were recruited. The Smartphone Application-Based Addiction Scale, Bergen Social Media Addiction Scale, Internet Gaming Disorder-Short Form, and Self-Stigma Scale-Short Form were used. No significant associations between PUI and self-stigma were found in early waves (i.e., Waves 1 and 2). The earliest significant finding was identified between Wave 2 PSPU (smartphone) and Wave 3 self-stigma. Additionally, Wave 3 PSPU (smartphone) and PG (gaming) were associated with Wave 4 self-stigma, and Wave 4 PSPU (smartphone), PG (gaming), and PUSM (social media) were associated with Wave 5 self-stigma. Therefore, all three types of PUI (internet) may elevate self-stigma at different time points for individuals with SUDs. However, the reciprocal effects between self-stigma and PUI (internet) only occurred in PUSM (social media) at a later stage (i.e., from Wave 4 to Wave 5). In conclusion, people with SUDs who have PUI (internet) are at increased likelihood of developing more self-stigma, which may then increase subsequent PUSM (social media), forming a vicious cycle.

Published
2022
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