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1. Relationship of Fatigue, Pain Interference, and Physical Disability in Children Newly Diagnosed With Juvenile Idiopathic Arthritis

Author

Choong, Naomi, Batthish, Michelle, Berard, Roberta A., Chédeville, Gaëlle, Feldman, Brian M., Houghton, Kristin M., Huber, Adam M., James, Sarah, Proulx‐Gauthier, Jean‐Philippe, Rumsey, Dax G., Schmeling, Heinrike, Toupin‐April, Karine, Guzman, Jaime, Cabral, David A., Chédeville, Gaëlle, Duffy, Ciarán M., Gerhold, Kerstin, Guzman, Jaime, Hiraki, Linda, Huber, Adam M., Schmeling, Heinrike, Shiff, Natalie J., Tucker, Lori B., Barsalou, Julie, Basodan, Daniah, Batthish, Michelle, Berard, Roberta A., Blanchette, Nicholas, Boire, Gilles, Bolaria, Roxana, Bruns, Alessandra, Cabral, David, Campillo, Sarah, Cellucci, Tania, Chan, Mercedes, Chédeville, Gaëlle, Chhabra, Amieleena, Couture, Julie, Dancey, Paul, De Bruycker, Jean‐Jacques, Demirkaya, Erkan, Dhalla, Muhammed, Duffy, Ciarán M., El Tal, Talal, Gerschman, Tommy, Guzman, Jaime, Heale, Liane, Herrington, Julie, Houghton, Kristin M., Huber, Adan M., Human, Andrea, Johnson, Nicole, Jurencak, Roman, Lang, Bianca, LeBlanc, Claire, Lim, Lilian, Lim, Lily S. H., Luca, Nadia, McColl, Jeanine, McGrath, Tara, McMillan, Tamara, McPherson, Megan, Miettunen, Paivi, Morishita, Kimberly, Ng, Honyan, Park, Jonathan, Proulx‐Gauthier, Jean‐Philippe, Roth, Johannes, Rozenblyum, Evelyn, Rumsey, Dax G., Schmeling, Heinrike, Scuccimarri, Rosie, Soon, Gordon, Stevenson, Rebeka, Stringer, Elizabeth, Tam, Herman, Tucker, Lori B., Twilt, Marinka, Verstegen, Ruud H. J., and Duffy, Karen Watanabe

Abstract

Our objectives were to quantify the relationships among fatigue, pain interference, and physical disability in children with juvenile idiopathic arthritis (JIA) and to test whether fatigue mediates the relationship between pain interference and physical disability in JIA. Patients enrolled within three months of JIA diagnosis in the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) Registry between February 2017 and May 2023 were included. Their parents completed the Patient‐Reported Outcomes Measurement Information System fatigue and pain interference short proxy questionnaires and the Childhood Health Assessment Questionnaire disability index at registry enrollment. Associations were assessed using Pearson correlations and multiple linear regression. Structural equation modeling (SEM) was used to test if fatigue mediates the relationship between pain interference and physical disability. Among 855 patients (61.4% female, 44.1% with oligoarthritis), most reported fatigue and pain interference scores similar to those in the reference population, but 15.6% reported severe fatigue and 7.3% reported severe pain interference, with wide variation across JIA categories. Fatigue was strongly correlated with pain interference (r = 0.72, P< 0.001) and with physical disability (r= 0.60, P< 0.001). Pain interference (β = 0.027, P< 0.001) and fatigue (β = 0.013, P< 0.001) were both associated with physical disability after controlling for each other and potential confounders. SEM supported our hypothesis that fatigue partially mediates the relationship between pain interference and physical disability. Our findings suggest both fatigue and pain interference are independently associated with physical disability in children newly diagnosed with JIA, and the effect of pain interference may be partly mediated by fatigue.

Published
2024
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2. Higher concentrations of vitamin D in Canadian children with juvenile idiopathic arthritis compared to healthy controls are associated with more frequent use of vitamin D supplements and season of birth

Author

Finch, Sarah L., Rosenberg, Alan M., Kusalik, Anthony J., Maleki, Farhad, Rezaei, Elham, Baxter-Jones, Adam, Benseler, Susanne, Boire, Gilles, Cabral, David, Campillo, Sarah, Chédeville, Gaëlle, Chetaille, Anne-Laure, Dancey, Paul, Duffy, Ciaran, Duffy, Karen Watanabe, Guzman, Jaime, Houghton, Kristin, Huber, Adam M., Jurencak, Roman, Lang, Bianca, Laxer, Ron M., Morishita, Kimberly, Oen, Kiem G., Petty, Ross E., Ramsey, Suzanne E., Roth, Johannes, Schneider, Rayfel, Scuccimarri, Rosie, Stringer, Elizabeth, Tse, Shirley M.L., Tucker, Lori B., Turvey, Stuart E., Szafron, Michael, Whiting, Susan, Yeung, Rae SM, and Vatanparast, Hassan

Published
2021
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3. Parent‐Reported Medication Side Effects and Their Impact on Health‐Related Quality of Life in Children With Juvenile Idiopathic Arthritis

Author

Chédeville, Gaëlle, McGuire, Katherine, Cabral, David A., Shiff, Natalie J., Rumsey, Dax G., Proulx‐Gauthier, Jean‐Philippe, Schmeling, Heinrike, Berard, Roberta A., Batthish, Michelle, Soon, Gordon, Gerhold, Kerstin, Gerschman, Tommy, Bruns, Alessandra, Duffy, Ciaran M., Tucker, Lori B., and Guzman, Jaime

Published
2022
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5. Phenotypic variability and disparities in treatment and outcomes of childhood arthritis throughout the world: an observational cohort study

Author

Abdwani, Reem, Aghighi, Yahya, Aiche, Maya-Feriel, Ailioaie, Constantin, Aktay Ayaz, Nuray, Al-Abrawi, Safiya, Alexeeva, Ekaterina, Anton, Jordi, Apostol, Adriana, Arguedas, Olga, Avcin, Tadej, Barone, Patrizia, Berntson, Lillemor, Boteanu, Alina Lucica, Boyko, Yaryna, Burgos-Vargas, Ruben, Calvo Penades, Inmaculada, Chédeville, Gaëlle, Cimaz, Rolando, Civino, Adele, Consolini, Rita, Constantin, Tamas, Cuttica, Ruben, Dallos, Tomas, Martin, Neil, Magni Manzoni, Silvia, De Cunto, Carmen, Dolezalova, Pavla, Ekelund, Maria, El Miedany, Yasser, Espada, Graciela, Estmann Christensen, Anne, Foeldvari, Ivan, Gallizzi, Romina, Ganser, Gerd, Gerloni, Valeria, Haas, Johannes-Peter, Harel, Liora, Harjacek, Miroslav, Hashad, Soad, Herlin, Troels, Herrera, Cristina, Hofer, Michael, Holzinger, Dirk, Horneff, Gerd, Huppertz, Hans-Iko, Iagăru, Nicolae, Ibanez Estrella, Amparo, Ioseliani, Maka, Joos, Rik, Knupp Oliveira, Sheila, Kamphuis, Sylvia, Kasapcopur, Ozgur, Katsicas, Maria Martha, Khubchandani, Raju, Kondi, Anuela, Kröger, Liisa, La Torre, Francesco, Laday, Matilda, Lahdenne, Pekka, Maggio, Maria Cristina, Magnolia, Maria Greca, Malagon, Clara, Malin, Merja, Martino, Silvana, Melo-Gomes, Jose Antonio, Mesa-del-Castillo, Pablo, Militaru, Andrea, Minden, Kirsten, Miniaci, Angela, Moradinejad, Mohammad Hasan, Morel Ayala, Zoilo, Nikishina, Irina, Norambuena, Ximena, Nordal, Ellen Berit, Pagava, Karaman, Panaviene, Violeta, Pastore, Serena, Pieropan, Sara, Podda, Rosa Anna, Pruunsild, Chris, Putto-Laurila, Anne, Quartier, Pierre, Remesal, Agustin, Rigante, Donato, Ringold, Sarah, Rutkowska-Sak, Lidia, Rygg, Marite, Saurenmann, Rotraud Katharina, Sawhney, Sujata, Scott, Christiaan, Shiari, Reza, Smolewska, Elzbieta, Sozeri, Betul, Swart, Joost Frans, Sztajnbok, Flavio, Torcoletti, Marta, Tsitsami, Elena, Tzaribachev, Nikolay, Unsal, Erbil, Uziel, Yosef, Vähäsalo, Paula, Varbanova, Boriana, Vargova, Veronika, Vesely, Richard, Vijatov-Djuric, Gordana, Vilaiyuk, Soamarat, Vojinovic, Jelena, Vougiouka, Olga, Weiss, Pamela, Wouters, Carine, Consolaro, Alessandro, Giancane, Gabriella, Alongi, Alessandra, van Dijkhuizen, Evert Hendrik Pieter, Aggarwal, Amita, Al-Mayouf, Sulaiman M, Bovis, Francesca, De Inocencio, Jaime, Demirkaya, Erkan, Flato, Berit, Foell, Dirk, Garay, Stella Maris, Lazăr, Călin, Lovell, Daniel J, Montobbio, Carolina, Miettunen, Paivi, Mihaylova, Dimitrina, Nielsen, Susan, Orban, Ilonka, Rumba-Rozenfelde, Ingrida, Magalhães, Claudia Saad, Shafaie, Nahid, Susic, Gordana, Trachana, Maria, Wulffraat, Nico, Pistorio, Angela, Martini, Alberto, Ruperto, Nicolino, and Ravelli, Angelo

Published
2019
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6. A decade of progress in juvenile idiopathic arthritis treatments and outcomes in Canada: results from ReACCh-Out and the CAPRI registry.

Author

Nguyen, Kelly, Barsalou, Julie, Basodan, Daniah, Batthish, Michelle, Benseler, Susanne M, Berard, Roberta A, Blanchette, Nicholas, Boire, Gilles, Bolaria, Roxana, Bruns, Alessandra, Cabral, David A, Cameron, Bonnie, Campillo, Sarah, Cellucci, Tania, Chan, Mercedes, Chédeville, Gaëlle, Chetaille, Anne-Laure, Chhabra, Amieleena, Couture, Julie, and Dancey, Paul

Subjects
JUVENILE idiopathic arthritis, RESEARCH funding, MULTIPLE regression analysis, ANTIRHEUMATIC agents, REPORTING of diseases, TREATMENT effectiveness, DESCRIPTIVE statistics, LONGITUDINAL method, KAPLAN-Meier estimator, COMPARATIVE studies, CONFIDENCE intervals, PROPORTIONAL hazards models, CHILDREN
Abstract

Objective To assess changes in juvenile idiopathic arthritis (JIA) treatments and outcomes in Canada, comparing 2005–2010 and 2017–2021 inception cohorts. Methods Patients enrolled within three months of diagnosis in the Research in Arthritis in Canadian Children Emphasizing Outcomes (ReACCh-Out) and the Canadian Alliance of Pediatric Rheumatology Investigators Registry (CAPRI) cohorts were included. Cumulative incidences of drug starts and outcome attainment within 70 weeks of diagnosis were compared with Kaplan–Meier survival analysis and multivariable Cox regression. Results The 2005–2010 and 2017–2021 cohorts included 1128 and 721 patients, respectively. JIA category distribution and baseline clinical juvenile idiopathic arthritis disease activity (cJADAS10) scores at enrolment were comparable. By 70 weeks, 6% of patients (95% CI 5, 7) in the 2005–2010 and 26% (23, 30) in the 2017–2021 cohort had started a biologic DMARD (bDMARD), and 43% (40, 47) and 60% (56, 64) had started a conventional DMARD (cDMARD), respectively. Outcome attainment was 64% (61, 67) and 83% (80, 86) for inactive disease (Wallace criteria), 69% (66, 72) and 84% (81, 87) for minimally active disease (cJADAS10 criteria), 57% (54, 61) and 63% (59, 68) for pain control (<1/10), and 52% (47, 56) and 54% (48, 60) for good health-related quality of life (≥9/10). Conclusion Although baseline disease characteristics were comparable in the 2005–2010 and 2017–2021 cohorts, cDMARD and bDMARD use increased with a concurrent increase in minimally active and inactive disease. Improvements in parent and patient-reported outcomes were smaller than improvements in disease activity. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Blau Syndrome–Associated Uveitis: Preliminary Results From an International Prospective Interventional Case Series

Author

Sarens, Inge L., Casteels, Ingele, Anton, Jordi, Bader-Meunier, Brigitte, Brissaud, Philippe, Chédeville, Gaelle, Cimaz, Rolando, Dick, Andrew D., Espada, Graciella, Fernandez-Martin, Jorge, Guly, Catherine M., Hachulla, Eric, Harjacek, Miroslav, Khubchandani, Raju, Mackensen, Friederike, Merino, Rosa, Modesto, Consuelo, Naranjo, Antonio, Oliveira-Knupp, Sheila, Özen, Seza, Pajot, Christine, Ramanan, Athimalaipet V., Russo, Ricardo, Susic, Gordana, Thatayatikom, Akaluck, Thomée, Caroline, Vastert, Sebastiaan, Bertin, John, Arostegui, Juan I., Rose, Carlos D., and Wouters, Carine H.

Published
2018
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8. A decade of progress in juvenile idiopathic arthritis treatments and outcomes in Canada: results from ReACCh-Out and the CAPRI registry

Author

Nguyen, Kelly, primary, Barsalou, Julie, additional, Basodan, Daniah, additional, Batthish, Michelle, additional, Benseler, Susanne M, additional, Berard, Roberta A, additional, Blanchette, Nicholas, additional, Boire, Gilles, additional, Bolaria, Roxana, additional, Bruns, Alessandra, additional, Cabral, David A, additional, Cameron, Bonnie, additional, Campillo, Sarah, additional, Cellucci, Tania, additional, Chan, Mercedes, additional, Chédeville, Gaëlle, additional, Chetaille, Anne-Laure, additional, Chhabra, Amieleena, additional, Couture, Julie, additional, Dancey, Paul, additional, De Bruycker, Jean-Jacques, additional, Demirkaya, Erkan, additional, Dhalla, Muhammed, additional, Duffy, Ciarán M, additional, Feldman, Brian M, additional, Feldman, Debbie E, additional, Gerschman, Tommy, additional, Haddad, Elie, additional, Heale, Liane, additional, Herrington, Julie, additional, Houghton, Kristin, additional, Huber, Adam M, additional, Human, Andrea, additional, Johnson, Nicole, additional, Jurencak, Roman, additional, Lang, Bianca, additional, Larché, Maggie, additional, Laxer, Ronald M, additional, LeBlanc, Claire M, additional, Lee, Jennifer J Y, additional, Levy, Deborah M, additional, Lim, Lillian, additional, Lim, Lily S H, additional, Luca, Nadia, additional, McGrath, Tara, additional, McMillan, Tamara, additional, Miettunen, Paivi M, additional, Morishita, Kimberly A, additional, Ng, Hon Yan, additional, Oen, Kiem, additional, Park, Jonathan, additional, Petty, Ross E, additional, Proulx-Gauthier, Jean-Philippe, additional, Ramsey, Suzanne, additional, Roth, Johannes, additional, Rosenberg, Alan M, additional, Rozenblyum, Evelyn, additional, Rumsey, Dax G, additional, Schmeling, Heinrike, additional, Schneider, Rayfel, additional, Scuccimarri, Rosie, additional, Shiff, Natalie J, additional, Silverman, Earl, additional, Soon, Gordon, additional, Spiegel, Lynn, additional, Stringer, Elizabeth, additional, Tam, Herman, additional, Tse, Shirley M, additional, Tucker, Lori B, additional, Turvey, Stuart, additional, Twilt, Marinka, additional, Duffy, Karen Watanabe, additional, Yeung, Rae S M, additional, and Guzman, Jaime, additional

Published
2023
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10. Choosing Wisely: The Canadian Rheumatology Association Pediatric Committee’s List of Items Physicians and Patients Should Question

Author

Lim, Lillian, primary, McMillan, Tara, additional, Chédeville, Gaëlle, additional, Lahiry, Piya, additional, Lee, Jennifer J.Y., additional, Heale, Liane D., additional, Human, Andrea L., additional, McGrath, Tara R., additional, MacQueen, Sue E., additional, Stringer, Elizabeth, additional, Jariwala, Mehul P., additional, Neufeld, Kate M., additional, Soon, Gordon S., additional, Spiegel, Lynn R., additional, and Luca, Nadia J.C., additional

Published
2023
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11. Canadian Rheumatology Association Recommendations for the Screening, Monitoring, and Treatment of Juvenile Idiopathic Arthritis-associated Uveitis

Author

Berard, Roberta, primary, Ng, Hon Yan, additional, Human, Andrea, additional, Piskin, David, additional, Dhalla, Muhammed, additional, Gottlieb, Chloe, additional, Batthish, Michelle, additional, Chédeville, Gaëlle, additional, Forest, Christina, additional, Fortin, Eric, additional, Gardiner, Jane, additional, Gerhold, Kerstin, additional, Jastrzebski, Andre, additional, Lang, Bianca, additional, Miettunen, Paivi M.H., additional, Morgenstern, Sabrina, additional, Morin, Marie-Paule, additional, Rosenberg, Alan, additional, Rumsey, Dax G., additional, Solarte, Carlos E., additional, Tehrani, Nasrin, additional, Watanabe Duffy, Karen, additional, Pardo Pardo, Jordi, additional, Hazlewood, Glen S., additional, and Levy, Deborah M., additional

Published
2022
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13. Trajectories of pain severity in juvenile idiopathic arthritis: results from the Research in Arthritis in Canadian Children Emphasizing Outcomes cohort

Author

Shiff, Natalie J., Tupper, Susan, Oen, Kiem, Guzman, Jaime, Lim, Hyun, Lee, Chel Hee, Bryce, Rhonda, Huber, Adam M., Boire, Gilles, Dancey, Paul, Feldman, Brian, Laxer, Ronald, Miettunen, Paivi, Schmeling, Heinrike, Watanabe Duffy, Karen, Levy, Deborah M., Turvey, Stuart, Bolaria, Roxana, Bruns, Alessandra, Cabral, David A., Campillo, Sarah, Chédeville, Gaëlle, Feldman, Debbie Ehrmann, Haddad, Elie, Houghton, Kristin, Johnson, Nicole, Jurencak, Roman, Lang, Bianca, Larche, Maggie, Morishita, Kimberly, Ramsey, Suzanne, Roth, Johannes, Schneider, Rayfel, Scuccimarri, Rosie, Spiegel, Lynn, Stringer, Elizabeth, Tse, Shirley M., Yeung, Rae, Duffy, Ciarán M., and Tucker, Lori B.

Published
2018
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14. Predictors of persisting pain in children with Juvenile Idiopathic Arthritis: a case control study nested in the ReACCh-Out cohort.

Author

McGrath, Tara, Guzman, Jaime, Tucker, Lori, Shiff, Natalie J., Yaskina, Maryna, Tupper, Susan, Rumsey, Dax G., for the Research in Arthritis in Canadian Children Emphasizing Outcomes (ReACCh-Out) Investigators, Benseler, Susanne, Berard, Roberta, Boire, Gilles, Bolaria, Roxana, Cabral, David, Cameron, Bonnie, Campillo, Sarah, Chan, Mercedes, Chédeville, Gaëlle, Chetaille, Anne-Laure, Dancey, Paul, and Dorval, Jean

Subjects
JUVENILE idiopathic arthritis, RHEUMATOID factor, PAIN measurement, VISUAL analog scale, LOGISTIC regression analysis
Abstract

Background: To identify baseline predictors of persisting pain in children with Juvenile Idiopathic Arthritis (JIA), relative to patients with JIA who had similar baseline levels of pain but in whom the pain did not persist. Methods: We used data from the Research in Arthritis in Canadian Children emphasizing Outcomes (ReACCh-Out) inception cohort to compare cases of 'moderate persisting pain' with controls of 'moderate decreasing pain'. Moderate pain was defined as a Visual Analogue Scale (VAS) for pain measurement score of > 3.5 cm. Follow-up was minimum 3 years. Univariate and Multivariate logistic regression models ascertained baseline predictors of persisting pain. Results: A total of 31 cases and 118 controls were included. Mean pain scores at baseline were 6.4 (SD 1.6) for cases and 5.9 (1.5) for controls. A greater proportion of cases than controls were females (77.4% vs 65.0%) with rheumatoid factor positive polyarthritis (12.9% vs 4.2%) or undifferentiated JIA (22.6% vs 8.5%). Oligoarthritis was less frequent in cases than controls (9.7% vs 33%). At baseline, cases had more active joints (mean of 11.4 vs 7.7) and more sites of enthesitis (4.6 vs 0.7) than controls. In the final multivariate regression model, enthesitis count at baseline (OR 1.40, CI 95% 1.19–1.76), female sex (4.14, 1.33–16.83), and the overall Quality of My Life (QoML) baseline score (0.82, 0.69–0.98) predicted development of persisting pain. Conclusions: Among newly diagnosed children with JIA with moderate pain, female sex, lower overall quality of life, and higher enthesitis counts at baseline predicted development of persisting pain. If our findings are confirmed, patients with these characteristics may be candidates for interventions to prevent development of chronic pain. [ABSTRACT FROM AUTHOR]

Published
2023
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16. Table S1 - Supplemental material for Prevalence and Incidence of Localized Scleroderma: A Qualitative Systematic Review

Author

Mahmood, Farhan, Nguyen, Alex, Muntyanu, Anastasiya, Jfri, Abdulhadi, McCuaig, Catherine, Chédeville, Gaëlle, Piram, Maryam, and Netchiporouk, Elena

Subjects
Medicine
Abstract

Supplemental material, Table S1, for Prevalence and Incidence of Localized Scleroderma: A Qualitative Systematic Review by Farhan Mahmood, Alex Nguyen, Anastasiya Muntyanu, Abdulhadi Jfri, Catherine McCuaig, Gaëlle Chédeville, Maryam Piram and Elena Netchiporouk in Journal of Cutaneous Medicine and Surgery

Published
2022
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17. The risk and nature of flares in juvenile idiopathic arthritis: results from the ReACCh-Out cohort

Author

Guzman, Jaime, Oen, Kiem, Huber, Adam M, Watanabe Duffy, Karen, Boire, Gilles, Shiff, Natalie, Berard, Roberta A, Levy, Deborah M, Stringer, Elizabeth, Scuccimarri, Rosie, Morishita, Kimberly, Johnson, Nicole, Cabral, David A, Rosenberg, Alan M, Larché, Maggie, Dancey, Paul, Petty, Ross E, Laxer, Ronald M, Silverman, Earl, Miettunen, Paivi, Chetaille, Anne-Laure, Haddad, Elie, Houghton, Kristin, Spiegel, Lynn, Turvey, Stuart E, Schmeling, Heinrike, Lang, Bianca, Ellsworth, Janet, Ramsey, Suzanne E, Bruns, Alessandra, Roth, Johannes, Campillo, Sarah, Benseler, Susanne, Chédeville, Gaëlle, Schneider, Rayfel, Tse, Shirley M L, Bolaria, Roxana, Gross, Katherine, Feldman, Brian, Feldman, Debbie, Cameron, Bonnie, Jurencak, Roman, Dorval, Jean, LeBlanc, Claire, St. Cyr, Claire, Gibbon, Michele, Yeung, Rae S M, Duffy, Ciarán M, and Tucker, Lori B

Published
2016
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18. Comparing Canadian paediatric rheumatology practice to the 2019 ACR Juvenile Idiopathic Arthritis guidelines: results from the CAPRI Registry.

Author

Park, Jonathan, Batthish, Michelle, Berard, Roberta A, Chédeville, Gaëlle, Proulx-Gauthier, Jean-Philippe, Rumsey, Dax G, Tucker, Lori B, Wong, Stephanie, Guzman, Jaime, and Investigators, for the CAPRI Registry

Subjects
BIOTHERAPY, RHEUMATOLOGY, NONSTEROIDAL anti-inflammatory agents, JUVENILE idiopathic arthritis, PEDIATRICS, ACQUISITION of data, MEDICAL protocols, COMPARATIVE studies, SURVEYS, RHEUMATOLOGISTS, METHOTREXATE, ANTIRHEUMATIC agents, MEDICAL records, KAPLAN-Meier estimator, DESCRIPTIVE statistics, RESEARCH funding, SACROILIITIS, LONGITUDINAL method
Abstract

Objective To identify differences between baseline Canadian JIA practices and the 2019 ACR guidelines for JIA. Methods Canadian paediatric rheumatologists were surveyed for their opinions on reasonable a priori target adherence rates for JIA guideline recommendations. Prospectively collected data for 266 newly diagnosed children from 2017 to 2019 were analysed to calculate observed adherence rates. Kaplan–Meier survival curves were used to estimate the cumulative incidence of starting synthetic or biologic DMARDs (sDMARD or bDMARD, respectively) for different patient groups. Results A total of 25/61 (41%) eligible physicians answered the survey. Most survey respondents (64%) felt that adherence targets should vary depending on the strength of the recommendation and quality of evidence, from a mean of 84% for strong recommendations with high-quality evidence to 29% for conditional recommendations with very low-quality evidence. Data showed 13/19 (68%) recommendations would have met proposed targets and 10/19 (53%) had ≥80% observed adherence. Exceptions were the use of subcutaneous vs oral MTX (53%) and infrequent treatment escalation from NSAIDs to bDMARDs in patients with sacroiliitis (31%) or enthesitis (0%). By 12 weeks, 95% of patients with polyarthritis received sDMARDs, 38% of patients with systemic JIA received bDMARDs and 22% of patients with sacroiliitis received bDMARDs. Conclusion Canadian paediatric rheumatology practices were in line with many 2019 JIA guideline recommendations before their publication, except for frequent use of oral MTX and infrequent direct escalation from NSAIDs to bDMARDs in sacroiliitis and enthesitis. [ABSTRACT FROM AUTHOR]

Published
2023
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19. The outcomes of juvenile idiopathic arthritis in children managed with contemporary treatments: results from the ReACCh-Out cohort

Author

Guzman, Jaime, Oen, Kiem, Tucker, Lori B, Huber, Adam M, Shiff, Natalie, Boire, Gilles, Scuccimarri, Rosie, Berard, Roberta, Tse, Shirley M L, Morishita, Kimberly, Stringer, Elizabeth, Johnson, Nicole, Levy, Deborah M, Duffy, Karen Watanabe, Cabral, David A, Rosenberg, Alan M, Larché, Maggie, Dancey, Paul, Petty, Ross E, Laxer, Ronald M, Silverman, Earl, Miettunen, Paivi, Chetaille, Anne-Laure, Haddad, Elie, Houghton, Kristin, Spiegel, Lynn, Turvey, Stuart E, Schmeling, Heinrike, Lang, Bianca, Ellsworth, Janet, Ramsey, Suzanne, Bruns, Alessandra, Campillo, Sarah, Benseler, Susanne, Chédeville, Gaëlle, Schneider, Rayfel, Yeung, Rae, Duffy, Ciarán M, Bolaria, Roxana, Gross, Katherine, Feldman, Brian, Feldman, Debbie, Cameron, Bonnie, Jurencak, Roman, Roth, Johannes, Dorval, Jean, LeBlanc, Claire, and St. Cyr, Claire

Published
2015
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21. Canadian Rheumatology Association Recommendations for the Screening, Monitoring, and Treatment of Juvenile Idiopathic Arthritis-Associated Uveitis.

Author

Berard, Roberta, Hon Yan Ng, Human, Andrea, Piskin, David, Dhalla, Muhammed, Gottlieb, Chloe, Batthish, Michelle, Chédeville, Gaëlle, Forest, Christina, Fortin, Eric, Gardiner, Jane, Gerhold, Kerstin, Jastrzebski, Andre, Lang, Bianca, Miettunen, Paivi M. H., Morgenstern, Sabrina, Morin, Marie-Paule, Rosenberg, Alan, Rumsey, Dax G., and Solarte, Carlos E.

Published
2023
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22. International Consensus for the Dosing of Corticosteroids in Childhood-Onset Systemic Lupus Erythematosus With Proliferative Lupus Nephritis

Author

Chalhoub, Nathalie E., Wenderfer, Scott E., Levy, Deborah M., Rouster-Stevens, Kelly, Aggarwal, Amita, Savani, Sonia I., Ruth, Natasha M., Arkachaisri, Thaschawee, Qiu, Tingting, Merritt, Angela, Onel, Karen, Goilav, Beatrice, Khubchandani, Raju P., Deng, Jianghong, Fonseca, Adriana R., Ardoin, Stacy P., Ciurtin, Coziana, Kasapcopur, Ozgur, Jelusic, Marija, Huber, Adam M., Ozen, Seza, Klein-Gitelman, Marisa S., Appenzeller, Simone, Cavalcanti, André, Fotis, Lampros, Lim, Sern Chin, Silva, Rodrigo M., Miramontes, Julia Ramírez, Rosenwasser, Natalie L., Saad-Magalhaes, Claudia [UNESP], Schonenberg-Meinema, Dieneke, Scott, Christiaan, Silva, Clovis A., Enciso, Sandra, Terreri, Maria T., Torres-Jimenez, Alfonso-Ragnar, Trachana, Maria, Al-Mayouf, Sulaiman M., Devarajan, Prasad, Huang, Bin, Brunner, Hermine I., Abulaban, Khalid, Aguiar, Cassyanne, Ahn, Sun-Young, Akoghlanian, Shoghik, Al-Abrawi, Safiya, Aljaberi, Najla, Alperin, Risa, Angeles-Han, Sheila, Ardalan, Kaveh, Bader-Meunier, Brigitte, Balboni, Imelda, Barbar-Smiley, Fatima, Baxter, Sarah, Beary, John, Boneparth, Alexis, Brakeman, Paul, Bridges, John, Burgos-Vargas, Ruben, Cabral, David A., Cameto, Juan, Carter, Caitlin, Chang, Joyce, Chédeville, Gaëlle, Chhakchhuak, Christine, Chiraseveenuprapund, Peter, Cifuentes Alvarado, Mayra, Concannon, Anthony, Cooper, Jennifer, Cron, Randy, De Carvalho, Luciana Martins, De Quattro, Kimberly, De Ranieri, Deirdre, Dizon, Brian, Donnelly Wrigley, Catherine, Duong, Minh Dien, Eberhard, Anne, Ede, Kaleo, Edelheit, Barbara, Edens, Cuoghi, Espada, Graciela, Farhey, Yolanda, Flores, Francisco, Fritz, Deborah, Ganguli, Suhas, Gilbert, Mileka, Gittar, Patsy, Greenbaum, Larry, Grom, Alexei, Gulati, Gaurav, Harry, Onengiya, Hayward, Kristen, Henrickson, Michael, Hersh, Aimee, Hiraki, Linda, Hiskey, Megan, Hoffmann, Sarah, Hollander, Matthew, Hom, Christine, Houk, Lawrence, Houk, J. Brian, Hsieh, Elena W.Y., Hsu, Joyce, Jensen, Paul, Joos, Rik, Jurado, Rosario, Jusan Fiorot, Fernanda, Kallash, Mahmoud, Kamphuis, Sylvia, Keltsev, Vladimir, Khanna, Surabhi, Kim, Susan, Kimseng, Karen Joy, Knight, Andrea, Kunder, Rebecca, Lai, Jamie, Laskin, Benjamin, Lewandowski, Laura, Lim, Lily, Linda, Wagner-Weiner, Lo, Mindy, Lovell, Daniel, Luggen, Michael, Madison, Jacqueline, Mansuri, Asif, Martin, Lorena, Mason, Sherene, Miller, Michael, Mina, Rina, Mohammed, Abdul, Moncrieffe, Halima, Moorthy, Lakshmi, Morgan, Esi, Mosquera, Angela, Muntel, Emily, Muscal, Eyal, Myones, Barry, Nocton, James, Ogbu, Ekemini, Okamura, Daryl, Olson, Judyann, Orrock, Janet, Paim-Marques, Luciana, Pain, Clare, Park, Catherine, Patel, Pooja, Pereira, Maria, Prado, Rogerio do, Radhakrishna, Suhas, Rheault, Michelle, Ridgway, William, Riskalla, Mona, Ronis, Tova, Sadun, Rebecca, Sagcal-Gironella, Anna Carmela, Santos, Maria carolina, Schikler, Kenneth, AL Suwairi, Wafaa, Siddiqi, Nabeela, Silva, Marco Felipe, Singh-Grewal, Davinder, Smitherman, Emily, Smolewska, Elzbieta, Son, Mary Beth, Srinivasalu, Hemalatha, Sule, Sangeeta, Susic, Gordana, Syed, Reema, Thatayatikom, Akaluck, Ting, Tracy, Toth, Mary, Turnier, Jessica, Vashisht, Priyanka, Vega Fernandez, Patricia, Velasquez, Monica, von Scheven, Emily, Wahezi, Dawn, Ware, Avis, Wu, Eveline, Yan, Jacqueline, Yildirim-Toruner, Cagri, Zamparo, Celso, Zhang, Yujuan, Lawson, Erica, Graduate School, Paediatric Infectious Diseases / Rheumatology / Immunology, AII - Inflammatory diseases, University of Cincinnati College of Medicine, Baylor College of Medicine, The Hospital for Sick Children and The University of Toronto, Emory University and Children's Healthcare of Atlanta, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Medical University of South Carolina, KK Women's and Children's Hospital, Cincinnati Children's Hospital Medical Center, Hospital for Special Surgery, Albert Einstein College of Medicine, SRCC Children's Hospital, Capital Medical University and National Center for Children's Health, Universidade Federal do Rio de Janeiro (UFRJ), Nationwide Children's Hospital, University College London, Istanbul University-Cerrahpasa, University of Zagreb School of Medicine, IWK Health Centre and Dalhousie University, Hacettepe University, Northwestern University Feinberg School of Medicine and Ann & Robert H. Lurie Children's Hospital of Chicago, Universidade Estadual de Campinas (UNICAMP), Universidade Federal de Pernambuco (UFPE), National and Kapodistian University of Athens, University Teknologi MARA, Instituto Mexicano del Seguro Social, University of Washington and Seattle Children's Hospital, Universidade Estadual Paulista (UNESP), Amsterdam University Medical Center, Red Cross War Memorial Children's Hospital and University of Cape Town, Universidade de São Paulo (USP), Hospital de la Beneficencia Española, Universidade Federal de São Paulo (UNIFESP), National Medical Center La Raza, Aristotle University of Thessaloniki, King Faisal Specialist Hospital and Research Center and Alfaisal University, and University of Cincinnati College of Medicine and Cincinnati Children's Hospital Medical Center

Subjects
Male, medicine.medical_specialty, Adolescent, medicine.drug_class, Immunology, Lupus nephritis, Renal function, Article, Rheumatology, childhood-onset systemic lupus erythematosus, corticosteroids, lupus nephritis, treatment, Internal medicine, Biopsy, Immunology and Allergy, Medicine, Humans, Lupus Erythematosus, Systemic, Dosing, Age of Onset, Child, Glucocorticoids, Retrospective Studies, Kidney, Proteinuria, medicine.diagnostic_test, business.industry, food and beverages, medicine.disease, Lupus Nephritis, Clinical trial, medicine.anatomical_structure, Corticosteroid, Female, medicine.symptom, business
Abstract

Made available in DSpace on 2022-04-28T19:49:00Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-02-01 Arthritis Foundation Institute of Clinical and Translational Sciences Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institute of Diabetes and Digestive and Kidney Diseases National Center for Advancing Translational Sciences Objective: To develop a standardized steroid dosing regimen (SSR) for physicians treating childhood-onset systemic lupus erythematosus (SLE) complicated by lupus nephritis (LN), using consensus formation methodology. Methods: Parameters influencing corticosteroid (CS) dosing were identified (step 1). Data from children with proliferative LN were used to generate patient profiles (step 2). Physicians rated changes in renal and extrarenal childhood-onset SLE activity between 2 consecutive visits and proposed CS dosing (step 3). The SSR was developed using patient profile ratings (step 4), with refinements achieved in a physician focus group (step 5). A second type of patient profile describing the course of childhood-onset SLE for ≥4 months since kidney biopsy was rated to validate the SSR-recommended oral and intravenous (IV) CS dosages (step 6). Patient profile adjudication was based on majority ratings for both renal and extrarenal disease courses, and consensus level was set at 80%. Results: Degree of proteinuria, estimated glomerular filtration rate, changes in renal and extrarenal disease activity, and time since kidney biopsy influenced CS dosing (steps 1 and 2). Considering these parameters in 5,056 patient profile ratings from 103 raters, and renal and extrarenal course definitions, CS dosing rules of the SSR were developed (steps 3–5). Validation of the SSR for up to 6 months post–kidney biopsy was achieved with 1,838 patient profile ratings from 60 raters who achieved consensus for oral and IV CS dosage in accordance with the SSR (step 6). Conclusion: The SSR represents an international consensus on CS dosing for use in patients with childhood-onset SLE and proliferative LN. The SSR is anticipated to be used for clinical care and to standardize CS dosage during clinical trials. University of Cincinnati College of Medicine Baylor College of Medicine The Hospital for Sick Children and The University of Toronto Emory University and Children's Healthcare of Atlanta Sanjay Gandhi Postgraduate Institute of Medical Sciences Medical University of South Carolina KK Women's and Children's Hospital Cincinnati Children's Hospital Medical Center Hospital for Special Surgery Albert Einstein College of Medicine SRCC Children's Hospital Capital Medical University and National Center for Children's Health Universidade Federal do Rio de Janeiro Nationwide Children's Hospital University College London Cerrahpasa Medical School Istanbul University-Cerrahpasa University of Zagreb School of Medicine IWK Health Centre and Dalhousie University Hacettepe University Northwestern University Feinberg School of Medicine and Ann & Robert H. Lurie Children's Hospital of Chicago University of Campinas Hospital das Clínicas da Universidade Federal de Pernambuco National and Kapodistian University of Athens University Teknologi MARA Instituto Mexicano del Seguro Social University of Washington and Seattle Children's Hospital São Paulo State University Amsterdam University Medical Center Red Cross War Memorial Children's Hospital and University of Cape Town Universidade de São Paulo Hospital de la Beneficencia Española Universidade Federal de São Paulo National Medical Center La Raza Aristotle University of Thessaloniki King Faisal Specialist Hospital and Research Center and Alfaisal University University of Cincinnati College of Medicine and Cincinnati Children's Hospital Medical Center São Paulo State University CNPq: 303422/2015-7 FAPESP: FAPESP 2015/03756-4 National Institute of Arthritis and Musculoskeletal and Skin Diseases: P30-AR-076316 National Institute of Diabetes and Digestive and Kidney Diseases: P50-DK-096418 National Institute of Arthritis and Musculoskeletal and Skin Diseases: R34-AR-071651 National Center for Advancing Translational Sciences: T32-AR-050958

Published
2021

23. Additional file 1 of Clinical and psychosocial stress factors are associated with decline in physical activity over time in children with juvenile idiopathic arthritis

Author

Heale, Liane D., Houghton, Kristin M., Rezaei, Elham, Baxter-Jones, Adam D. G., Tupper, Susan M., Muhajarine, Nazeem, Benseler, Susanne M., Boire, Gilles, Cabral, David A., Campillo, Sarah, Chédeville, Gaëlle, Chetaille, Anne-Laure, Dancey, Paul, Duffy, Ciaran, Duffy, Karen Watanabe, Ellsworth, Janet, Guzman, Jaime, Huber, Adam M., Jurencak, Roman, Lang, Bianca, Laxer, Ronald M., Morishita, Kimberly, Oen, Kiem G., Petty, Ross E., Ramsey, Suzanne E., Roth, Johannes, Schneider, Rayfel, Scuccimarri, Rosie, Spiegel, Lynn, Stringer, Elizabeth, Tse, Shirley M. L., Tucker, Lori B., Turvey, Stuart E., Yeung, Rae S. M., and Rosenberg, Alan M.

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2021
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24. Development and validation of the Kids Disability Screen for children with juvenile idiopathic arthritis: results from the CAPRI Registry.

Author

Houghton, Kristin, McPherson, Meghan, Surjanovic, Nikola, Loughin, Thomas, Berard, Roberta, Proulx-Gauthier, Jean-Phillipe, Chédeville, Gaëlle, Rumsey, Dax, Schmeling, Heinrike, Luca, Nadia, Johnson, Nicole, Gerschman, Tommy, Miettunen, Paivi, Tam, Herman, Lim, Lillian, Morishita, Kimberly, Scuccimarri, Rosie, Roth, Johannes, Duffy, Ciaran, and Tucker, Lori

Subjects
EXPERIMENTAL design, RESEARCH methodology, RESEARCH methodology evaluation, JUVENILE idiopathic arthritis, REGRESSION analysis, FUNCTIONAL assessment, PSYCHOMETRICS, DESCRIPTIVE statistics, SENSITIVITY & specificity (Statistics), LONGITUDINAL method, DISEASE complications
Abstract

Objective The aim of this study was to develop and validate a brief disability screen for children with JIA, the Kids Disability Screen (KDS). Methods A total of 216 children enrolled in the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) Registry in 2017–2018 formed a development cohort, and 220 children enrolled in 2019–2020 formed a validation cohort. At every clinic visit, parents answered two questions derived from the Childhood Health Assessment Questionnaire (CHAQ): 'Is it hard for your child to run and play BECAUSE OF ARTHRITIS?' ('Hard' 0–10), and 'Does your child usually need help from you or another person BECAUSE OF ARTHRITIS?' ('Help', 0–10). We used 36-fold cross-validation and tested nine different mathematical methods to combine the answers and optimize psychometric properties. The results were confirmed in the validation cohort. Results Expressed as the mean of the two answers, KDS best balanced ease of use and psychometric properties, while a LASSO regression model combining the two answers with other patient characteristics [estimated CHAQ [eCHAQ]) had the highest responsiveness. In the validation cohort, 22.7%, 25.9% and 28.6% of patients had a score of 0 at enrolment for the KDS, eCHAQ and CHAQ, respectively. Responsiveness was 0.67, 0.74 and 0.62, respectively. Sensitivity to detect a CHAQ > 0 was 0.90 and specificity 0.56, KDS detecting some disability in 44% of children with a CHAQ = 0. Conclusion This simple KDS has psychometric properties comparable with those of a full CHAQ and may be used at every clinic visit to identify those children who need a full disability assessment. [ABSTRACT FROM AUTHOR]

Published
2022
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25. Incidence, prevalence, and mortality of localized scleroderma in Quebec, Canada: a population-based study

Author

Ghazal, Stephanie, Muntyanu, Anastasiya, Aw, Katherine, Kaouache, Mohammed, Khoury, Lauren, Piram, Maryam, McCuaig, Catherine, Chédeville, Gaëlle, Rahme, Elham, Osman, Mohammed, Schachter, Jordana, Bertrand, Janie, and Netchiporouk, Elena

Abstract

Localized scleroderma is an understudied autoimmune disease characterized by fibrosis of the skin and/or subcutaneous tissue. Only 6 articles report incidence and/or prevalence estimates globally, with significant design limitations and risk of bias. None of the studies originated from Canada or investigated mortality/geospatial epidemiology. We aimed to study the incidence, prevalence, mortality and spatiotemporal trends of localized scleroderma in Quebec, Canada, stratified by sex and age.

Published
2025
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26. Predicting Which Children with Juvenile Idiopathic Arthritis Will Not Attain Early Remission with Conventional Treatment: Results from the ReACCh-Out Cohort

Author

Guzman, Jaime, Henrey, Andrew, Loughin, Thomas, Berard, Roberta A., Shiff, Natalie J., Jurencak, Roman, Huber, Adam M., Oen, Kiem, Gerhold, Kerstin, Feldman, Brian M., Scuccimarri, Rosie, Houghton, Kristin, Chédeville, Gaëlle, Morishita, Kimberly, Lang, Bianca, Dancey, Paul, Rosenberg, Alan M., Barsalou, Julie, Bruns, Alessandra, Duffy, Karen Watanabe, Benseler, Susanne, Duffy, Ciaran M., Tucker, Lori B., Bolaria, Roxana, Gross, Katherine, Turvey, Stuart E., Cabral, David, Petty, Ross, and Ellsworth, Janet

Subjects
Male, Pediatrics, medicine.medical_specialty, Adolescent, Immunology, Arthritis, Early remission, Logistic regression, Severity of Illness Index, Decile, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, medicine, Humans, Immunology and Allergy, Juvenile, Treatment Failure, 030212 general & internal medicine, Child, Risk stratification, 030203 arthritis & rheumatology, Biological Products, business.industry, Remission Induction, Conventional treatment, Juvenile idiopathic arthritis, Prognosis, medicine.disease, Arthritis, Juvenile, Logistic Models, Treatment Outcome, Antirheumatic Agents, Child, Preschool, Cohort, Cohort studies, Female, Prediction, business, Cohort study
Abstract

Objective.To estimate the probability of early remission with conventional treatment for each child with juvenile idiopathic arthritis (JIA). Children with a low chance of remission may be candidates for initial treatment with biologics or triple disease-modifying antirheumatic drugs (DMARD).Methods.We used data from 1074 subjects in the Research in Arthritis in Canadian Children emphasizing Outcomes (ReACCh-Out) cohort. The predicted outcome was clinically inactive disease for ≥ 6 months starting within 1 year of JIA diagnosis in patients who did not receive early biologic agents or triple DMARD. Models were developed in 200 random splits of 75% of the cohort and tested on the remaining 25% of subjects, calculating expected and observed frequencies of remission and c-index values.Results.Our best Cox logistic model combining 18 clinical variables a median of 2 days after diagnosis had a c-index of 0.69 (95% CI 0.67–0.71), better than using JIA category alone (0.59, 95% CI 0.56–0.63). Children in the lowest probability decile had a 20% chance of remission and 21% attained remission; children in the highest decile had a 69% chance of remission and 73% attained remission. Compared to 5% of subjects identified by JIA category alone, the model identified 14% of subjects as low chance of remission (probability < 0.25), of whom 77% failed to attain remission.Conclusion.Although the model did not meet our a priori performance threshold (c-index > 0.70), it identified 3 times more subjects with low chance of remission than did JIA category alone, and it may serve as a benchmark for assessing value added by future laboratory/imaging biomarkers.

Published
2019
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30. Predictors of Early Inactive Disease in a Juvenile Idiopathic Arthritis Cohort: Results of a Canadian Multicenter, Prospective Inception Cohort Study

Author

OEN, KIEM, TUCKER, LORI, HUBER, ADAM M., MIETTUNEN, PAIVI, SCUCCIMARRI, ROSIE, CAMPILLO, SARAH, CABRAL, DAVID A., FELDMAN, BRIAN M., TSE, SHIRLEY, CHéDEVILLE, GAëLLE, SPIEGEL, LYNN, SCHNEIDER, RAYFEL, LANG, BIANCA, ELLSWORTH, JANET, RAMSEY, SUZANNE, DANCEY, PAUL, SILVERMAN, EARL, CHETAILLE, ANNE-LAURE, CAMERON, BONNIE, JOHNSON, NICOLE, DORVAL, JEAN, PETTY, ROSS E., DUFFY, KAREN WATANABE, BOIRE, GILLES, HADDAD, ELIE, HOUGHTON, KRISTIN, SAINT-CYR, CLAIRE, TURVEY, STUART E., BENSELER, SUSANNE, CHEANG, MARY, YEUNG, RAE S. M., and DUFFY, CIARáN M.

Published
2009
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34. Parent‐ReportedMedication Side Effects and Their Impact on Health‐RelatedQuality of Life in Children With Juvenile Idiopathic Arthritis

Author

Chédeville, Gaëlle, McGuire, Katherine, Cabral, David A., Shiff, Natalie J., Rumsey, Dax G., Proulx‐Gauthier, Jean‐Philippe, Schmeling, Heinrike, Berard, Roberta A., Batthish, Michelle, Soon, Gordon, Gerhold, Kerstin, Gerschman, Tommy, Bruns, Alessandra, Duffy, Ciaran M., Tucker, Lori B., and Guzman, Jaime

Abstract

To describe the frequency and severity of parent‐reported medication side effects (SEs) in children with juvenile idiopathic arthritis (JIA) relative to physician‐reported actionable adverse events (AEs), and to assess their impact on health‐related quality of life (HRQoL). Newly diagnosed JIA patients recruited between 2017 and 2019 to the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) Registry were included. Parents reported presence and severity (0 = no problem, 10 = very severe) of medication SEs at every clinic visit. Physicians were asked to report any actionable AE. HRQoL was assessed using the Quality of My Life (QoML) questionnaire (0 = the worst, 10 = the best) and parent's global assessment (0 = very well, 10 = very poor). Analyses included proportion of visits with SEs or actionable AEs, cumulative incidence by Kaplan‐Meier methods, and HRQoL impact measured with longitudinal mixed‐effects models. SEs were reported at 371 of 884 (42%) visits (95% confidence interval [95% CI] 39, 45%) in 249 patients, with a median of 2 SEs per visit (interquartile range [IQR] 1–3), and median severity of 3 (IQR 1.5–5). Most SEs were gastrointestinal (32.5% of visits) or behavioral/psychiatric (22.4%). SE frequency was lowest with nonsteroidal antiinflammatory drugs alone (34.7%) and highest with prednisone and methotrexate combinations (66%). SE cumulative incidence was 67% (95% CI 59, 75) within 1 year of diagnosis, and 36% (95% CI 28, 44) for actionable AEs. Parent global and QoML scores were worse with SEs present; the impact persisted after adjusting for pain and number of active joints. Parents report that two‐thirds of children with JIA experience SEs impacting their HRQoL within 1 year of diagnosis. SE mitigation strategies are needed in managing JIA.

Published
2022
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35. Munc13-4 Is Essential for Cytolytic Granules Fusion and Is Mutated in a Form of Familial Hemophagocytic Lymphohistiocytosis (FHL3)

Author

Feldmann, Jérôme, Callebaut, Isabelle, Raposo, Graça, Certain, Stéphanie, Bacq, Delphine, Dumont, Cécile, Lambert, Nathalie, Ouachée-Chardin, Marie, Chedeville, Gaëlle, Tamary, Hannah, Minard-Colin, Véronique, Vilmer, Etienne, Blanche, Stéphane, Le Deist, Françoise, Fischer, Alain, and de Saint Basile, Geneviève

Published
2003
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36. Clinical and associated inflammatory biomarker features predictive of short-term outcomes in non-systemic juvenile idiopathic arthritis

Author

Rezaei, Elham, primary, Hogan, Daniel, additional, Trost, Brett, additional, Kusalik, Anthony J, additional, Boire, Gilles, additional, Cabral, David A, additional, Campillo, Sarah, additional, Chédeville, Gaëlle, additional, Chetaille, Anne-Laure, additional, Dancey, Paul, additional, Duffy, Ciaran, additional, Watanabe Duffy, Karen, additional, Gordon, John, additional, Guzman, Jaime, additional, Houghton, Kristin, additional, Huber, Adam M, additional, Jurencak, Roman, additional, Lang, Bianca, additional, Morishita, Kimberly, additional, Oen, Kiem G, additional, Petty, Ross E, additional, Ramsey, Suzanne E, additional, Scuccimarri, Rosie, additional, Spiegel, Lynn, additional, Stringer, Elizabeth, additional, Taylor-Gjevre, Regina M, additional, Tse, Shirley M L, additional, Tucker, Lori B, additional, Turvey, Stuart E, additional, Tupper, Susan, additional, Yeung, Rae S M, additional, Benseler, Susanne, additional, Ellsworth, Janet, additional, Guillet, Chantal, additional, Karananayake, Chandima, additional, Muhajarine, Nazeem, additional, Roth, Johannes, additional, Schneider, Rayfel, additional, and Rosenberg, Alan M, additional

Published
2020
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37. Kaposi’s sarcoma in a child with Wiskott-Aldrich syndrome

Author

Picard, Capucine, Mellouli, Fethi, Duprez, Renan, Chédeville, Gaëlle, Neven, Bénédicte, Fraitag, Sylvie, Delaunay, Jean, Le Deist, Françoise, Fischer, Alain, Blanche, Stéphane, Bodemer, Christine, Gessain, Antoine, Casanova, Jean-Laurent, and Bejaoui, Mohamed

Published
2006
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38. Feasibility and safety of a 6-month exercise program to increase bone and muscle strength in children with juvenile idiopathic arthritis

Author

Houghton, Kristin M., Macdonald, Heather M., McKay, Heather A., Guzman, Jaime, Duffy, Ciarán, Tucker, Lori, Berard, Roberta, Boire, Gilles, Bruns, Alessandra, Campillo, Sarah, Chédeville, Gaëlle, Dancey, Paul, Ellsworth, Janet, Feldman, Debbie, Huber, Adam, Johnson, Nicole, Jurencak, Roman, Leblanc, Claire, Levy, Deborah, Miettunen, Paivi, Morishita, Kimberly, Ramsey, Suzanne, Rosenberg, Alan, Roth, Johannes, Rumsey, Dax, Schmeling, Heinrike, Scuccimarri, Rosie, Shiff, Natalie, and Stringer, Elizabeth

Subjects
Male, lcsh:Diseases of the musculoskeletal system, Childhood arthritis, Arthritis, Radius bone, Cohort Studies, 0302 clinical medicine, Absorptiometry, Photon, Quality of life, Bone Density, Immunology and Allergy, 030212 general & internal medicine, Longitudinal Studies, Quantitative computed tomography, Child, medicine.diagnostic_test, lcsh:RJ1-570, Exercise Therapy, medicine.anatomical_structure, Treatment Outcome, Muscle, Female, medicine.symptom, Exercise prescription, Research Article, medicine.medical_specialty, Canada, Adolescent, Juvenile arthritis, 03 medical and health sciences, Rheumatology, Internal medicine, medicine, Humans, Muscle Strength, Bone, Exercise, 030203 arthritis & rheumatology, business.industry, Physical activity, Muscle weakness, lcsh:Pediatrics, medicine.disease, Arthritis, Juvenile, Pediatrics, Perinatology and Child Health, Physical therapy, Quality of Life, Feasibility Studies, Patient Compliance, lcsh:RC925-935, business, Tomography, X-Ray Computed
Abstract

Background Arthritis in childhood can be associated with muscle weakness around affected joints, low bone mass and low bone strength. Exercise is recognized as an important part of management of children with juvenile idiopathic arthritis (JIA) but the exercise prescription to best promote bone and muscle health is unknown. We therefore aimed to: 1. assess feasibility and safety of a 6-month home- and group-based exercise program for children with JIA; 2. estimate the effect of program participation on bone mass and strength, muscle function and clinical outcomes and 3. determine if any positive changes in bone and muscle outcomes are maintained 6 months later. Methods We recruited 24 children with JIA who were part of the Linking Exercise, Physical Activity and Pathophysiology in Childhood Arthritis (LEAP) study to participate in a 6-month home-based exercise program involving jumping and handgrip exercises, resistance training and one group exercise session per month. We assessed lumbar spine bone mass (dual energy X-ray absorptiometry), distal tibia and radius bone microarchitecture and strength (high-resolution peripheral quantitative computed tomography), muscle function (jumping mechanography, dynamometry) and clinical outcomes (joint assessment, function, health-related quality of life) at baseline, 6- and 12-months. Adherence was assessed using weekly activity logs. Results Thirteen children completed the 6-month intervention. Participants reported 9 adverse events and post-exercise pain was rare (0.4%). Fatigue improved, but there were no other sustained improvements in muscle, bone or clinical outcomes. Adherence to the exercise program was low (47%) and decreased over time. Conclusion Children with JIA safely participated in a home-based exercise program designed to enhance muscle and bone strength. Fatigue improved, which may in turn facilitate physical activity participation. Prescribed exercise posed adherence challenges and efforts are needed to address facilitators and barriers to participation in and adherence to exercise programs among children with JIA. Trial registration Data of the children with JIA are from the LEAP study (Canadian Institutes of Health Research (CIHR; GRANT# 107535). http://www.leapjia.com/ Electronic supplementary material The online version of this article (10.1186/s12969-018-0283-4) contains supplementary material, which is available to authorized users.

Published
2018

39. Real‐World Effectiveness of Common Treatment Strategies for Juvenile Idiopathic Arthritis: Results From a Canadian Cohort

Author

Chhabra, Amieleena, Oen, Kiem, Huber, Adam M., Shiff, Natalie J., Boire, Gilles, Benseler, Susanne M., Berard, Roberta A., Scuccimarri, Rosie, Feldman, Brian M., Lim, Lily Siok Hoon, Barsalou, Julie, Bruns, Alessandra, Cabral, David A., Chédeville, Gaëlle, Ellsworth, Janet, Houghton, Kristin, Lang, Bianca, Morishita, Kimberly, Rumsey, Dax G., Rosenberg, Alan M., Tse, Shirley M., Watanabe Duffy, Karen, Duffy, Ciaran M., Guzman, Jaime, Bolaria, Roxana, Gross, Katherine, Turvey, Stuart E., Chan, Mercedes, Tucker, Lori B., Petty, Ross, Johnson, Nicole, Luca, Nadia, Miettunen, Paivi, Schmeling, Heinrike, Gerhold, Kerstin, Larché, Maggie, Levy, Deborah M., Laxer, Ronald M., Feldman, Debbie, Spiegel, Lynn, Schneider, Rayfel, Silverman, Earl, Cameron, Bonnie, Yeung, Rae S. M., Roth, Johannes, Jurencak, Roman, Gibbon, Michele, Chetaille, Anne‐Laure, Dorval, Jean, Campillo, Sarah, LeBlanc, Claire, Chédeville, Gaëlle, Haddad, Elie, Cyr, Claire St., Ramsey, Suzanne E., Stringer, Elizabeth, and Dancey, Paul

Abstract

Undervaluing the effectiveness of conventional treatments may lead to overtreatment with biologic medications in children with juvenile idiopathic arthritis (JIA). Using data from a nationwide inception cohort and strict methods to control bias, the aim of our study was to estimate the real‐world effectiveness of simple JIAtreatment strategies recommended in current guidelines. Children with JIAwho were recruited at 16 Canadian centers from 2005 to 2010 were followed for up to 5 years. For each child, all observed treatment changes over time were assessed by independent physicians using prospectively collected data and published response criteria. Success was defined as attainment of inactive disease or maintenance of this state when stepping down treatment; minimally active disease was deemed acceptable for children with polyarticular JIA. Success rates were calculated for treatments tried ≥25 times, and logistic regression analysis identified features associated with success. A total of 4,429 treatment episodes were observed in 1,352 children. Nonsteroidal antiinflammatory drug (NSAID) monotherapy was attempted 697 times, mostly as initial treatment when <5 joints were involved, with a 54.4% success rate (95% confidence interval [95% CI] 50.3–58.6). NSAIDs plus joint injections had a 64.7% success rate (95% CI59.8–69.7). Adding methotrexate to NSAIDs and/or joint injections (attempted 566 times) had a 60.5% success rate (95% CI55.7–65.3). In adjusted analyses, each additional active joint reduced chances of success for treatment with NSAIDs (odds ratio [OR] 0.90 [95% CI0.85–0.94]) and for methotrexate combinations (OR0.96 [95% CI0.94–0.99]). Each additional year after disease onset reduced chances of success for treatment with methotrexate combinations (OR0.83 [95% CI0.72–0.95]). These real‐world effectiveness estimates show that conventional nonbiologic treatment strategies that are recommended in current guidelines are effective in achieving treatment targets in many children with JIA.

Published
2020
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40. SAT0613 CHANGING TREATMENTS AND OUTCOMES FOR JUVENILE IDIOPATHIC ARTHRITIS: INITIAL FINDINGS FROM A NEW CANADIAN INCEPTION COHORT

Author

Guzman, Jaime, primary, Batthish, Michelle, additional, Berard, Roberta, additional, Bolaria, Roxana, additional, Cabral, David, additional, Chédeville, Gaëlle, additional, Duffy, Ciaran, additional, Gerhold, Kerstin, additional, Gerschman, Tommy, additional, Huber, Adam, additional, Proulx-Gauthier, Jean-Philippe, additional, Rosenberg, Alan, additional, Rumsey, Dax, additional, Schmeling, Heinrike, additional, Shiff, Natalie, additional, Soon, Gordon, additional, and Tucker, Lori, additional

Published
2019
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41. Phenotypic variability and disparities in treatment and outcomes of childhood arthritis throughout the world: an observational cohort study

Author

Consolaro, Alessandro, primary, Giancane, Gabriella, additional, Alongi, Alessandra, additional, van Dijkhuizen, Evert Hendrik Pieter, additional, Aggarwal, Amita, additional, Al-Mayouf, Sulaiman M, additional, Bovis, Francesca, additional, De Inocencio, Jaime, additional, Demirkaya, Erkan, additional, Flato, Berit, additional, Foell, Dirk, additional, Garay, Stella Maris, additional, Lazăr, Călin, additional, Lovell, Daniel J, additional, Montobbio, Carolina, additional, Miettunen, Paivi, additional, Mihaylova, Dimitrina, additional, Nielsen, Susan, additional, Orban, Ilonka, additional, Rumba-Rozenfelde, Ingrida, additional, Magalhães, Claudia Saad, additional, Shafaie, Nahid, additional, Susic, Gordana, additional, Trachana, Maria, additional, Wulffraat, Nico, additional, Pistorio, Angela, additional, Martini, Alberto, additional, Ruperto, Nicolino, additional, Ravelli, Angelo, additional, Abdwani, Reem, additional, Aghighi, Yahya, additional, Aiche, Maya-Feriel, additional, Ailioaie, Constantin, additional, Aktay Ayaz, Nuray, additional, Al-Abrawi, Safiya, additional, Alexeeva, Ekaterina, additional, Anton, Jordi, additional, Apostol, Adriana, additional, Arguedas, Olga, additional, Avcin, Tadej, additional, Barone, Patrizia, additional, Berntson, Lillemor, additional, Boteanu, Alina Lucica, additional, Boyko, Yaryna, additional, Burgos-Vargas, Ruben, additional, Calvo Penades, Inmaculada, additional, Chédeville, Gaëlle, additional, Cimaz, Rolando, additional, Civino, Adele, additional, Consolini, Rita, additional, Constantin, Tamas, additional, Cuttica, Ruben, additional, Dallos, Tomas, additional, Martin, Neil, additional, Magni Manzoni, Silvia, additional, De Cunto, Carmen, additional, Dolezalova, Pavla, additional, Ekelund, Maria, additional, El Miedany, Yasser, additional, Espada, Graciela, additional, Estmann Christensen, Anne, additional, Foeldvari, Ivan, additional, Gallizzi, Romina, additional, Ganser, Gerd, additional, Gerloni, Valeria, additional, Haas, Johannes-Peter, additional, Harel, Liora, additional, Harjacek, Miroslav, additional, Hashad, Soad, additional, Herlin, Troels, additional, Herrera, Cristina, additional, Hofer, Michael, additional, Holzinger, Dirk, additional, Horneff, Gerd, additional, Huppertz, Hans-Iko, additional, Iagăru, Nicolae, additional, Ibanez Estrella, Amparo, additional, Ioseliani, Maka, additional, Joos, Rik, additional, Knupp Oliveira, Sheila, additional, Kamphuis, Sylvia, additional, Kasapcopur, Ozgur, additional, Katsicas, Maria Martha, additional, Khubchandani, Raju, additional, Kondi, Anuela, additional, Kröger, Liisa, additional, La Torre, Francesco, additional, Laday, Matilda, additional, Lahdenne, Pekka, additional, Maggio, Maria Cristina, additional, Magnolia, Maria Greca, additional, Malagon, Clara, additional, Malin, Merja, additional, Martino, Silvana, additional, Melo-Gomes, Jose Antonio, additional, Mesa-del-Castillo, Pablo, additional, Militaru, Andrea, additional, Minden, Kirsten, additional, Miniaci, Angela, additional, Moradinejad, Mohammad Hasan, additional, Morel Ayala, Zoilo, additional, Nikishina, Irina, additional, Norambuena, Ximena, additional, Nordal, Ellen Berit, additional, Pagava, Karaman, additional, Panaviene, Violeta, additional, Pastore, Serena, additional, Pieropan, Sara, additional, Podda, Rosa Anna, additional, Pruunsild, Chris, additional, Putto-Laurila, Anne, additional, Quartier, Pierre, additional, Remesal, Agustin, additional, Rigante, Donato, additional, Ringold, Sarah, additional, Rutkowska-Sak, Lidia, additional, Rygg, Marite, additional, Saurenmann, Rotraud Katharina, additional, Sawhney, Sujata, additional, Scott, Christiaan, additional, Shiari, Reza, additional, Smolewska, Elzbieta, additional, Sozeri, Betul, additional, Swart, Joost Frans, additional, Sztajnbok, Flavio, additional, Torcoletti, Marta, additional, Tsitsami, Elena, additional, Tzaribachev, Nikolay, additional, Unsal, Erbil, additional, Uziel, Yosef, additional, Vähäsalo, Paula, additional, Varbanova, Boriana, additional, Vargova, Veronika, additional, Vesely, Richard, additional, Vijatov-Djuric, Gordana, additional, Vilaiyuk, Soamarat, additional, Vojinovic, Jelena, additional, Vougiouka, Olga, additional, Weiss, Pamela, additional, and Wouters, Carine, additional

Published
2019
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43. Clinical and psychosocial stress factors are associated with decline in physical activity over time in children with juvenile idiopathic arthritis.

Author

Heale, Liane D., Houghton, Kristin M., Rezaei, Elham, Baxter-Jones, Adam D. G., Tupper, Susan M., Muhajarine, Nazeem, Benseler, Susanne M., Boire, Gilles, Cabral, David A., Campillo, Sarah, Chédeville, Gaëlle, Chetaille, Anne-Laure, Dancey, Paul, Duffy, Ciaran, Duffy, Karen Watanabe, Ellsworth, Janet, Guzman, Jaime, Huber, Adam M., Jurencak, Roman, and Lang, Bianca

Subjects
JUVENILE idiopathic arthritis, PHYSICAL activity, PSYCHOSOCIAL factors, TALLIES, JUVENILE diseases, PAIN, DISEASE duration
Abstract

Background: Physical activity (PA) patterns in children with juvenile idiopathic arthritis (JIA) over time are not well described. The aim of this study was to describe associations of physical activity (PA) with disease activity, function, pain, and psychosocial stress in the 2 years following diagnosis in an inception cohort of children with juvenile idiopathic arthritis (JIA). Methods: In 82 children with newly diagnosed JIA, PA levels, prospectively determined at enrollment, 12 and 24 months using the Physical Activity Questionnaire for Children (PAQ-C) and Adolescents (PAQ-A) raw scores, were evaluated in relation to disease activity as reflected by arthritis activity (Juvenile Arthritis Disease Activity Score (JADAS-71)), function, pain, and psychosocial stresses using a linear mixed model approach. Results in the JIA cohort were compared to normative Pediatric Bone Mineral Accrual Study data derived from healthy children using z-scores. Results: At enrollment, PA z-score levels of study participants were lower than those in the normative population (median z-score − 0.356; p = 0.005). At enrollment, PA raw scores were negatively associated with the psychosocial domain of the Juvenile Arthritis Quality of Life Questionnaire (r = − 0.251; p = 0.023). There was a significant decline in PAQ-C/A raw scores from baseline (median and IQR: 2.6, 1.4–3.1) to 24 months (median and IQR: 2.1, 1.4–2.7; p = 0.003). The linear mixed-effect model showed that PAQ-C/A raw scores in children with JIA decreased as age, disease duration, and ESR increased. The PAQ-C/A raw scores of the participants was also negatively influenced by an increase in disease activity as measured by the JADAS-71 (p < 0.001). Conclusion: Canadian children with newly diagnosed JIA have lower PA levels than healthy children. The decline in PA levels over time was associated with disease activity and higher disease-specific psychosocial stress. [ABSTRACT FROM AUTHOR]

Published
2021
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44. Soluble Low-density Lipoprotein Receptor-related Protein 1 in Juvenile Idiopathic Arthritis.

Author

Rezaei, Elham, Newkirk, Marianna M., Zhenhong Li, Gordon, John R., Oen, Kiem G., Benseler, Susanne M., Boire, Gilles, Cabral, David A., Campillo, Sarah, Chédeville, Gaëlle, Chetaille, Anne-Laure, Dancey, Paul, Duffy, Ciaran, Watanabe Duffy, Karen, Houghton, Kristin, Huber, Adam M., Jurencak, Roman, Lang, Bianca, Morishita, Kimberly A., and Petty, Ross E.

Published
2021
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45. Health-Related Quality of Life in an Inception Cohort of Children With Juvenile Idiopathic Arthritis: A Longitudinal Analysis

Author

Oen, Kiem, Guzman, Jaime, Dufault, Brenden, Tucker, Lori B, Shiff, Natalie J, Duffy, Karen Watanabe, Lee, Jennifer J Y, Feldman, Brian M, Berard, Roberta A, Dancey, Paul, Huber, Adam M, Scuccimarri, Rosie, Cabral, David A, Morishita, Kimberly A, Ramsey, Suzanne E, Rosenberg, Alan M, Boire, Gilles, Benseler, Susanne M, Lang, Bianca, Houghton, Kristin, Miettunen, Paivi M, Chédeville, Gaëlle, Levy, Deborah M, Bruns, Alessandra, Schmeling, Heinrike, Haddad, Elie, Yeung, Rae S M, Duffy, Ciarán M, and The Research in Arthritis in Canadian Children emphasizing Outcomes (ReACCh-Out) investigators

Subjects
Male, Pediatrics, Time Factors, Arthritis, Child Behavior, Disability Evaluation, 0302 clinical medicine, Child Development, Quality of life, Surveys and Questionnaires, Medicine, longitudinal studies, Longitudinal Studies, 030212 general & internal medicine, Child, Pain Measurement, Oligoarthritis, adolescent development, Age Factors, Prognosis, humanities, female, arthritis, Predictive value of tests, Child, Preschool, Cohort, Female, Polyarthritis, medicine.medical_specialty, age factors, Canada, Adolescent, disability evaluation, adolescent behavior, pain measurement, preschool, 03 medical and health sciences, Rheumatology, Predictive Value of Tests, Humans, Survival analysis, 030203 arthritis & rheumatology, business.industry, Adolescent Development, medicine.disease, Child development, Arthritis, Juvenile, juvenile, quality of life, Adolescent Behavior, Quality of Life, business
Abstract

Objective To describe changes in health-related quality of life (HRQoL) over time in children with juvenile idiopathic arthritis (JIA), relative to other outcomes, and to identify predictors of unfavorable HRQoL trajectories. Methods Children with JIA in the Research in Arthritis in Canadian Children emphasizing Outcomes (ReACCh-Out) cohort were included. The Juvenile Arthritis Quality of Life Questionnaire (JAQQ, a standardized instrument), health-related Quality of My Life (HRQoML, an instrument based on personal valuations), and JIA core variables were completed serially. Analyses included median values, Kaplan-Meier survival curves, and latent trajectory analysis. Results A total of 1,249 patients enrolled at a median of 0.5 months after diagnosis were followed for a median of 34.2 months. The degree of initial HRQoL impairment and probabilities of reaching the best possible HRQoL scores varied across JIA categories (best for oligoarthritis, worst for rheumatoid factor–positive polyarthritis). Median times to attain best possible HRQoL scores (JAQQ 59.3 months, HRQoML 34.5 months), lagged behind those for disease activity, pain, and disability measures. Most patients followed trajectories with minimal or mild impairment; however, 7.6% and 13.8% of patients, respectively, followed JAQQ and HRQoML trajectories with persistent major impairment in HRQoL. JIA category, aboriginal ethnicity, and baseline disease activity measures distinguished between membership in trajectories with major and minimal impairments. Conclusion Improvement in HRQoL is slower than for disease activity, pain, and disability. Improvement of a measure based on respondents’ preferences (HRQoML) is more rapid than that of a standardized measure (JAQQ). Higher disease activity at diagnosis heralds an unfavorable HRQoL trajectory.

Published
2018

46. A new Canadian inception cohort for juvenile idiopathic arthritis: The Canadian Alliance of Pediatric Rheumatology Investigators Registry.

Author

Batthish, Michelle, Berard, Roberta, Cabral, David, Bolaria, Roxana, Chédeville, Gaëlle, Duffy, Ciaran, Gerhold, Kerstin, Gerschman, Tommy, Huber, Adam, Proulx-Gauthier, Jean-Philippe, Rosenberg, Alan, Rumsey, Dax, Schmeling, Heinrike, Shiff, Natalie, Soon, Gordon, Bruns, Alessandra, Tucker, Lori, Guzman, Jaime, and Investigators, for The Canadian Alliance of Pediatric Rheumatology

Subjects
BIOTHERAPY, REPORTING of diseases, DRUG side effects, JUVENILE idiopathic arthritis, TREATMENT effectiveness, CONTENT mining, KAPLAN-Meier estimator
Abstract

Objectives The aim was to describe the design, methods and initial findings of a new Canadian inception cohort of children with JIA, The Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) JIA Registry. Methods The CAPRI JIA Registry was started in 2017 to collect information prospectively on children enrolled within 3 months of JIA diagnosis across Canada. The registry has a non-traditional modular design, with no artificially set times for registry visits to occur, streamlined multi-method data collection that requires 2–4 min per visit, and reports cumulative incidence of treatments, outcomes and adverse events calculated by Kaplan–Meier survival methods. Results A total of 166 patients, enrolled a median of 6 weeks after JIA diagnosis at 10 centres, were included. The median age at diagnosis was 9 years [interquartile range (IQR) 3, 13], 61% were female and 51% had oligoarticular JIA. The median three-variable clinical Juvenile Arthritis Disease Activity Score was 6.5 (IQR 4, 10) at enrolment, and the median time to first attainment of clinically inactive disease (CID) was 24 weeks (by 1 year, 81%). Within 1 year of diagnosis, 70% of patients had started a DMARD and 35% a biologic agent. The rates of adverse events and serious adverse events were 60 and 5.8 per 100 patient-years, respectively. Conclusion This streamlined and flexible registry minimizes the burden of data collection and interference with clinic operations. Initial findings suggest that treatments for newly diagnosed patients with JIA in Canada have intensified, and now 81% of patients attain CID within 1 year of diagnosis. [ABSTRACT FROM AUTHOR]

Published
2020
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47. Associations of clinical and inflammatory biomarker clusters with juvenile idiopathic arthritis categories.

Author

Rezaei, Elham, Hogan, Daniel, Trost, Brett, Kusalik, Anthony J, Boire, Gilles, Cabral, David A, Campillo, Sarah, Chédeville, Gaëlle, Chetaille, Anne-Laure, Dancey, Paul, Duffy, Ciaran, Duffy, Karen Watanabe, Eng, Simon W M, Gordon, John, Guzman, Jaime, Houghton, Kristin, Huber, Adam M, Jurencak, Roman, Lang, Bianca, and Laxer, Ronald M

Subjects
BIOMARKERS, CLUSTER analysis (Statistics), INFLAMMATION, JUVENILE idiopathic arthritis, DESCRIPTIVE statistics, KRUSKAL-Wallis Test
Abstract

Objective To identify discrete clusters comprising clinical features and inflammatory biomarkers in children with JIA and to determine cluster alignment with JIA categories. Methods A Canadian prospective inception cohort comprising 150 children with JIA was evaluated at baseline (visit 1) and after six months (visit 2). Data included clinical manifestations and inflammation-related biomarkers. Probabilistic principal component analysis identified sets of composite variables, or principal components, from 191 original variables. To discern new clinical-biomarker clusters (clusters), Gaussian mixture models were fit to the data. Newly-defined clusters and JIA categories were compared. Agreement between the two was assessed using Kruskal–Wallis analyses and contingency plots. Results Three principal components recovered 35% (three clusters) and 40% (five clusters) of the variance in patient profiles in visits 1 and 2, respectively. None of the clusters aligned precisely with any of the seven JIA categories but rather spanned multiple categories. Results demonstrated that the newly defined clinical-biomarker lustres are more homogeneous than JIA categories. Conclusion Applying unsupervised data mining to clinical and inflammatory biomarker data discerns discrete clusters that intersect multiple JIA categories. Results suggest that certain groups of patients within different JIA categories are more aligned pathobiologically than their separate clinical categorizations suggest. Applying data mining analyses to complex datasets can generate insights into JIA pathogenesis and could contribute to biologically based refinements in JIA classification. [ABSTRACT FROM AUTHOR]

Published
2020
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48. Trajectories of pain severity in juvenile idiopathic arthritis: results from the Research in Arthritis in Canadian Children Emphasizing Outcomes cohort

Author

Shiff, Natalie J., primary, Tupper, Susan, additional, Oen, Kiem, additional, Guzman, Jaime, additional, Lim, Hyun, additional, Lee, Chel Hee, additional, Bryce, Rhonda, additional, Huber, Adam M., additional, Boire, Gilles, additional, Dancey, Paul, additional, Feldman, Brian, additional, Laxer, Ronald, additional, Miettunen, Paivi, additional, Schmeling, Heinrike, additional, Watanabe Duffy, Karen, additional, Levy, Deborah M., additional, Turvey, Stuart, additional, Bolaria, Roxana, additional, Bruns, Alessandra, additional, Cabral, David A., additional, Campillo, Sarah, additional, Chédeville, Gaëlle, additional, Feldman, Debbie Ehrmann, additional, Haddad, Elie, additional, Houghton, Kristin, additional, Johnson, Nicole, additional, Jurencak, Roman, additional, Lang, Bianca, additional, Larche, Maggie, additional, Morishita, Kimberly, additional, Ramsey, Suzanne, additional, Roth, Johannes, additional, Schneider, Rayfel, additional, Scuccimarri, Rosie, additional, Spiegel, Lynn, additional, Stringer, Elizabeth, additional, Tse, Shirley M., additional, Yeung, Rae, additional, Duffy, Ciarán M., additional, and Tucker, Lori B., additional

Published
2017
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49. Growth and weight gain in children with juvenile idiopathic arthritis: results from the ReACCh-Out cohort

Author

Guzman, Jaime, primary, Kerr, Tristan, additional, Ward, Leanne M., additional, Ma, Jinhui, additional, Oen, Kiem, additional, Rosenberg, Alan M., additional, Feldman, Brian M., additional, Boire, Gilles, additional, Houghton, Kristin, additional, Dancey, Paul, additional, Scuccimarri, Rosie, additional, Bruns, Alessandra, additional, Huber, Adam M., additional, Watanabe Duffy, Karen, additional, Shiff, Natalie J., additional, Berard, Roberta A., additional, Levy, Deborah M., additional, Stringer, Elizabeth, additional, Morishita, Kimberly, additional, Johnson, Nicole, additional, Cabral, David A., additional, Larché, Maggie, additional, Petty, Ross E., additional, Laxer, Ronald M., additional, Silverman, Earl, additional, Miettunen, Paivi, additional, Chetaille, Anne-Laure, additional, Haddad, Elie, additional, Spiegel, Lynn, additional, Turvey, Stuart E., additional, Schmeling, Heinrike, additional, Lang, Bianca, additional, Ellsworth, Janet, additional, Ramsey, Suzanne E., additional, Roth, Johannes, additional, Campillo, Sarah, additional, Benseler, Susanne, additional, Chédeville, Gaëlle, additional, Schneider, Rayfel, additional, Tse, Shirley M. L., additional, Bolaria, Roxana, additional, Gross, Katherine, additional, Feldman, Debbie, additional, Cameron, Bonnie, additional, Jurencak, Roman, additional, Dorval, Jean, additional, LeBlanc, Claire, additional, St. Cyr, Claire, additional, Gibbon, Michele, additional, Yeung, Rae S. M., additional, Duffy, Ciarán M., additional, and Tucker, Lori B., additional

Published
2017
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50. Worse Quality of Life, Function, and Pain in Children With Enthesitis, Irrespective of Their Juvenile Arthritis Category.

Author

Rumsey, Dax G., Guzman, Jaime, Rosenberg, Alan M., Huber, Adam M., Scuccimarri, Rosie, Shiff, Natalie J., Bruns, Alessandra, Feldman, Brian M., Eurich, Dean T., Benseler, Susanne, Berard, Roberta, Boire, Gilles, Bolaria, Roxana, Cabral, David, Cameron, Bonnie, Campillo, Sarah, Chan, Mercedes, Chédeville, Gaëlle, Chetaille, Anne‐Laure, and Dancey, Paul

Subjects
RESEARCH, PAIN, RESEARCH methodology, JUVENILE idiopathic arthritis, EVALUATION research, MEDICAL cooperation, COMPARATIVE studies, QUALITY of life, QUESTIONNAIRES, LONGITUDINAL method
Abstract

Objective: To estimate the impact of enthesitis on patient-reported outcomes in children with juvenile idiopathic arthritis (JIA), irrespective of JIA category.Methods: Children enrolled in the Research in Arthritis in Canadian Children Emphasizing Outcomes cohort were studied. Entheseal tenderness by physician examination in 33 defined locations, Juvenile Arthritis Quality of Life Questionnaire (JAQQ), Quality of My Life (QoML) Questionnaire, Childhood Health Assessment Questionnaire (C-HAQ), and a pain visual analog scale were completed at enrollment, every 6 months for 2 years, and then yearly up to 5 years. Analyses consisted of descriptive statistics, linear mixed models for longitudinal data, and analysis of covariance.Results: Among 1,371 patients followed for a median of 35.3 months (interquartile range 22.1, 49.2), 214 (16%) had enthesitis, of whom 137 (64%) were classified as having enthesitis-related arthritis. After adjusting for JIA category and covariates, children with enthesitis reported higher JAQQ (mean raw score 2.71 versus 2.16, adjusted difference 0.41 points; 95% confidence interval [95% CI] 0.22, 0.59), higher C-HAQ (0.47 versus 0.31, adjusted difference 0.14 points; 95% CI 0.07, 0.22), higher pain (3.01 versus 1.68, adjusted difference 0.94 points; 95% CI 0.64, 1.25), and lower QoML (7.02 versus 8.23, adjusted difference -0.80 points; 95% CI -1.09, -0.51) scores than children without enthesitis. These differences persisted up to 5 years.Conclusion: Children with enthesitis, regardless of JIA category, report worse patient-reported outcomes than those without enthesitis. Thus, enthesitis should be assessed in all children with JIA. [ABSTRACT FROM AUTHOR]

Published
2020
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