Search

Your search keyword '"CETINEL, Sule"' showing total 284 results
Start Over Author "CETINEL, Sule"
284 results on '"CETINEL, Sule"'

7. Apocynin exhibits an ameliorative effect on endothelial dysfunction/ atherosclerosis-related factors in high-fat diet-induced obesity in rats.

Author

BULBUL AYCİ, Nurdan, ERTAS, Busra, KELEŞ KAYA, Rumeysa, KOCYIGIT SEVİNÇ, Sevgi, AMURAN, Gokce Gullu, ERCAN, Feriha, ŞENER, Göksel, ORUN, Oya, AKKIPRIK, Mustafa, and CETINEL, Sule

Subjects
BIOLOGICAL models, HIGH density lipoproteins, NUCLEOSIDES, LEPTIN, RESEARCH funding, APOPTOSIS, ATHEROSCLEROSIS, ENDOTHELIUM, DIETARY fats, INSULIN, OXIDATIVE stress, RATS, LOW density lipoproteins, OXIDOREDUCTASES, ANIMAL experimentation, CHOLESTEROL, GLYCOSIDES, TRIGLYCERIDES, OBESITY, CELLS, THORACIC aorta
Abstract

Objective: The aim of this study was to reveal the effect of apocynin (APO) on the factors involved in obesity-related endothelial dysfunction (ED) and atherosclerosis (AS). Materials and Methods: Male Wistar albino rats were divided into control (CNT), high-fat diet (HFD) and HFD+APO groups. HFD and HFD+APO groups were fed HFD for sixteen weeks. APO (25 mg/kg) was administered to the HFD+APO group for the last four weeks. The effects of APO on: AS-related metabolic parameters (triglyceride, total cholesterol, high-density lipoprotein-cholesterol, insulin and leptin), oxidative stress (OS), [ malondialdehyde, glutathione, nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase-2, oxidised-low-density lipoprotein (ox-LDL) and 8-hydroxy-2-deoxyguanosine], low-density lipoprotein and ox-LDL uptake potential (activin receptor-like kinase-1 and lectin-like oxidized low-density lipoprotein receptor-1, respectively), tissue inflammation (myeloperoxidase, monocyte-chemoattractant-protein-1, tumor necrosis factor-alpha), ED (endothelial-nitric oxide synthase, inducible-nitric oxide synthase, nitric oxide), programmed cell death (terminal deoxynucleotidyl-transferase-dUTP-nick-end labeling, cleaved-poly-ADP-ribose-polymerase, gasdermin-D N-terminal fragment, caspase-1), smooth muscle cell transformation (alpha-smooth muscle actin), histology and ultrastructure of thoracic aorta were evaluated. Results: In obesity, APO had an ameliorative effect on metabolic parameters, OS, inflammation, ED, programmed cell death and ox-LDL uptake potential, but not on foam cell formation and LDL uptake potential. Conclusion: Apocynin may improve ED and AS in obesity by suppressing OS-linked factors involved in the early stage of AS. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

8. Apocynin exhibits an ameliorative effect on endothelial dysfunction/ atherosclerosis-related factors in high-fat diet-induced obesity in rats

Author

Bülbül Aycı, Nurdan, primary, Ertaş, Büşra, additional, Keles Kaya, Rumeysa, additional, Kocyigit Sevinc, Sevgi, additional, Güllü Amuran, Gökçe, additional, Ercan, Feriha, additional, Şener, Göksel, additional, Orun, Oya, additional, Akkiprik, Mustafa, additional, and Cetinel, Sule, additional

Published
2023
Full Text
View/download PDF

9. The effect of Myrtus communis L. extract on nephrolithiasis model in rats.

Author

Ertas, Busra, Dorucu, Dogancan, Gulerturk, Oznur, Sen, Ali, Cevik, Ozge, Cetinel, Sule, Eker, Pinar, Akgun, Asuman, Sener, Tarik Emre, and Sener, Goksel

Subjects
KIDNEY stones, RATS, OXIDATIVE stress, KIDNEY failure, HISTOPATHOLOGY
Abstract

OBJECTIVE: Nephrolithiasis is a common urological disease that can lead to renal failure. Oxidative stress has been shown to be a contributing factor for nephrolithiasis and many agents have been studied to prevent and treat oxidative stress-related nephrolithiasis and renal damage. Myrtus communis (MC) extract has been shown to be an important antioxidant in different animal models. In this study, MC extract was administered preventively or therapeutically to rats with kidney stones, and its effectiveness was investigated. METHODS: Wistar albino rats were divided into four groups (n=8); control (C), ethylene glycol (EG), EG+preventive MC, and EG+curative MC groups. The nephrolithiasis model was created by adding 0.75% EG to drinking water for 8 weeks. Ultimately, 24-hour urine was collected to measure calcium, citrate, and creatinine levels. After decapitation, kidney tissues were harvested for histological analyses, measurement of osteopontin and 8-hydroxydeoxyguanosine (8-OHdG) levels, and N-acetyl-β-glucosaminidase (NAG), myeloperoxidase (MPO) and caspase-3 activities. RESULTS: In 24-hour urine samples, calcium, citrate and creatinine levels were decreased in the EG group, while oxalate levels were increased and in treatment groups these parameters returned to control levels. MPO, 8-OHdG, caspase-3 and NAG activity were significantly increased in tissue and these changes were reversed in both MC groups. Histological findings also supported the biochemical parameters. CONCLUSION: MC can reduce oxidative stress and histopathological changes in kidney tissues in rat nephrolithiasis model when used as either a preventive or therapeutic agent. If supported with further clinical trials, MC might have clinical implications in preventing oxidative renal cell injury and ultimately kidney stone formation. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

36. Chronic nicotine toxicity is prevented by aqueous garlic extract

Author

Sener, Goksel, Sehirli, A. Ozer, Ipci, Yesim, Cetinel, Sule, Cikler, Esra, and Gedik, Nursal

Subjects
Garlic -- Health aspects, Garlic -- Nutritional aspects, Garlic -- Analysis, Nicotine -- Complications and side effects, Oxidative stress -- Research, Oxidative stress -- Analysis, Health
Published
2005

44. Endothelin receptor blockers reduce I/R-induced intestinal mucosal injury: role of blood flow

Author

Oktar, Berna K., Gulpinar, M. Ali, Bozkurt, Ayhan, Ghandour, Salah, Cetinel, Sule, Moini, Hadi, Yegen, Berrak C., Bilsel, Serpil, Granger, D. Neil, and Kurtel, Hizir

Subjects
Endothelin -- Physiological aspects, Ischemia -- Physiological aspects, Mucous membrane -- Injuries, Biological sciences
Abstract

The aim of the present study was to assess the role of endothelin (ET) in ischemia-reperfusion (I/R)-induced mucosal injury. Mucosal permeability ([sup.51]Cr-EDTA clearance) and tissue myeloperoxidase (MPO) activity were significantly increased after 30 rain of ischemia followed by 30 min of reperfusion. The I/R-induced increases in mucosal permeability and polymorphonuclear leukocyte (PMN) infiltration were significantly attenuated by pretreatments with E[T.sub.A] (BQ-485) and/or E[T.sub.B] (BQ-788) receptor antagonists. Monoclonal antibody (MAb) directed against intercellular adhesion molecule-1 (ICAM-1; MAb 1A29) and superoxide dismutase (SOD) pretreatments significantly attenuated the increased mucosal permeability and PMN infiltration in a similar manner as with ET receptor antagonists. Superior mesenteric artery blood flow was significantly reduced during the reperfusion period. Both ET receptor antagonists caused a significant rise in blood flow compared with an untreated I/R group. In conclusion, our data suggest that E[T.sub.A] and/or E[T.sub.B] receptors, ICAM-1, and superoxide play an important role in I/R-induced mucosal dysfunction and PMN infiltration. Furthermore, ET is involved in the pathogenesis of postreperfusion-induced damage and beneficial effects of ET receptor antagonism are related to an improvement of disturbed blood flow during the reperfusion period. mucosal permeability; mucosal injury; BQ-485; BQ-788; superoxide dismutase

Published
2002

Catalog

Books, media, physical & digital resources
See catalog results