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3. Thermal Uses of Geothermal Energy, Country Update for Italy

Author

Bargiacchi E.[1, Conti P.[1, Manzella A.[1, Vaccaro M.[1], Cerutti P.[4], and Cesari G.[4]

Subjects
thermal uses, district heating, Ground Source Heat Pump (GSHP), thermal balneology, agricultural applications, fish farming, industrial processes, development, market, support measures
Abstract

This paper presents an overview on the development of thermal applications of geothermal energy in Italy since the last WGC2015. The Italian situation is described till the end of 2017, being this the most recent year for which data are available at the writing date of this report. The total installed capacity amounts to 1424 MWt, with a corresponding heat energy use of about 10915 TJ/yr. The main share is held by the space heating sector (42% of the total energy, 52% of the overall installed capacity), followed by thermal balneology (32% in both values) and fish farming (18% and 9% namely). Agricultural applications, industrial processes and other minor uses together account for around 8% of the total geo-heat use. Additionally, the paper presents a brief overview on the national geothermal potential, the current regulatory framework, and the main international research activities with Italian participation. The data show an overall stagnant situation for direct uses in Italy with respect to what described in WGC2015. The main drawbacks of the slow increase of geothermal thermal applications, to be overcome to ensure a new development phase for the geothermal energy in Italy, are presented and discussed.

Published
2021

6. Factors Influencing Depression Endpoints Research (FINDER): baseline results of Italian patients with depression

Author

Grassi, L, Rossi, A, Barraco, A, Italian Finder Group, Aguglia, E, Ambrosio, LA, Rossi, NB, Bellomo, A, Belloni, G, Biza, M, Bucci, N, Cappuccio, R, Carboni, MG, Cesari, G, Ciappi, F, Cipriani, AM, Cordioli, L, Delcuratolo, V, Di Cello, A, Di Fiorino, M, Di Lauro, A, Falabella, V, Falavolti, S, Farina, G, Federico, T, Gabrielli, F, Gazzera, G, Mariani, G, Minnai, G, Nano, D, Nicolo, G, Parnetti, L, Pierri, G, Puoti, M, Riccio, A, Romeo, A, Veneto, V, Lugo, I, Prodi, PR, Serrano, M, Sorbi, S, Toniolo, E, Venanzini, R, Vender, S, Venuta, M, Volpe, M., FERRARESE, CARLO, Grassi, L, Rossi, A, Barraco, A, Italian Finder, G, Aguglia, E, Ambrosio, L, Rossi, N, Bellomo, A, Belloni, G, Biza, M, Bucci, N, Cappuccio, R, Carboni, M, Cesari, G, Ciappi, F, Cipriani, A, Cordioli, L, Delcuratolo, V, Di Cello, A, Di Fiorino, M, Di Lauro, A, Falabella, V, Falavolti, S, Farina, G, Federico, T, Ferrarese, C, Gabrielli, F, Gazzera, G, Mariani, G, Minnai, G, Nano, D, Nicolo, G, Parnetti, L, Pierri, G, Puoti, M, Riccio, A, Romeo, A, Veneto, V, Lugo, I, Prodi, P, Serrano, M, Sorbi, S, Toniolo, E, Venanzini, R, Vender, S, Venuta, M, and Volpe, M

Subjects
Sertraline, medicine.medical_specialty, education.field_of_study, Visual analogue scale, business.industry, lcsh:RC435-571, Population, Depression Outcome, Depression, HRQoL, Hospital Anxiety and Depression Scale, Psychiatry and Mental health, Psychiatric history, lcsh:Psychiatry, depression, medicine, Escitalopram, Anxiety, medicine.symptom, Primary Research, business, Psychiatry, education, Depression (differential diagnoses), medicine.drug
Abstract

Background Factors Influencing Depression Endpoints Research (FINDER) is a 6-month, prospective, observational study carried out in 12 European countries aimed at investigating health-related quality of life (HRQoL) in outpatients receiving pharmacological treatment for a first or new depressive episode. Baseline characteristics of patients enrolled in Italy are presented. Methods All treatment decisions were at the discretion of the investigator. Data were collected at baseline and after 3 and 6 months of treatment. Baseline evaluations included demographics, medical and psychiatric history, and medications used in the last 24 months and prescribed at enrolment. The Hospital Anxiety and Depression Scale (HADS), was adopted to evaluate depressive symptoms, while somatic and painful physical symptoms were assessed by using the Somatic Symptom Inventory (SSI) and a 0 to 100 mm visual analogue scale (VAS), HRQoL via 36-item Short Form Health Survey (SF-36), and the European Quality of Life 5-Dimensions (EQ-5D) instrument. Results A total of 513 patients were recruited across 38 sites. The mean ± standard deviation (SD) age at first depressive episode was 38.7 ± 15.9 years, the mean duration of depression 10.6 ± 12.3 years. The most common psychiatric comorbidities in the previous 24 months were anxiety/panic (72.6%) and obsessive/compulsive disorders (13.4%), while 35.9% had functional somatic syndromes. Most patients (65.1%) reported pain from any cause. Monotherapy with selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs) was prescribed at enrolment in 64.5% and 6.4% of the cases, respectively. The most commonly prescribed agents were sertraline (17.3%), escitalopram (16.2%), venlaflaxine (15.6%) and paroxetine (14.8%). The mean HADS subscores for depression and anxiety were 13.3 ± 4.2 and 12.2 ± 3.9, respectively; 76.4% of patients could be defined as being 'probable cases' for depression and 66.2% for anxiety. The mean total score of VAS-pain in the last week was 42.9 ± 27.1, with highest scores reported in the 'interference of pain with daily activities' and in 'amount of time patient was awake and had pain'. From SF-36, the worst health status was found for role limitations due to emotional problem, mental health and social functioning. A mean score < 50 (that is, below the standardised population norm) was also found in all remaining domains. The SF-36 summary scores and EQ-5D (health status and VAS) were lower in patients with moderate/severe pain than in those with no or mild pain. Conclusion The baseline results of patients enrolled in the FINDER study in Italy show clinical and functional impairments, and poor HRQoL. The results obtained after 6 months of therapy will permit better understanding the effects of different variables on clinical outcomes and HRQoL.

Published
2009

11. Sintesi di derivati politiofenici ad alta versatilità strutturale

Author

Paganin, L., Costa Bizzarri, P., Lanzi, M., Cesari, G., Bertinelli, F., Cagnoli, Rita, Mucci, Adele, AIM (ASSOCIAZIONE ITALIANA DI SCIENZA E TENOLOGIA DELLE MACROMOLECOLE), L. Paganin, P. Costa Bizzarri, M. Lanzi, G. Cesari, F. Bertinelli, R. Cagnoli, and A. Mucci

Subjects
Synthesis, polythiophenes, characterization, oxidative coupling, GPC, solvatochromism, NMR spectroscopy
Published
2005

12. Extension of Guidelines for Seismically Isolated Reactors

Author

Sano', T., Olivieri, M., Martelli, A., Marioni, A., Forni, M., Di Pasquale, G., Cesari, G. F., Carpani, B., Bonacina, G., Sano', T., Olivieri, M., Martelli, A., Marioni, A., Forni, M., Di Pasquale, G., Cesari, G. F., Carpani, B., and Bonacina, G.

Subjects
Sistemi antisismici innovativi
Published
1993

23. Residues of rotenone, azadirachtin, pyrethrins and copper used to control Bactrocera oleae (Gmel.) in organic olives and oil.

Author

Simeone, V., Baser, N., Perrelli, D., Cesari, G., El Bilali, H., and Natale, P.

Subjects
OLIVE oil, ROTENONE, PYRETHRINS, OLIVE fly, BOTANICAL insecticides, LIQUID chromatography
Abstract

Rotenone, azadirachtin, pyrethrins and copper fungicide decay curves were determined in olives and olive oil samples after experimental trials, consisting of one, two and three applications of each active ingredient, were carried out twice in 2005 and 2006. Rotenone, azadiracthin and pyrethrins were analyzed by extraction with acetonitrile and determined by liquid chromatography; copper was extracted into aqueous HCl and determined by chemical stripping. Pyrethrins were always found but in levels below the acceptable limits, whereas rotenone and copper residues always exceeded, after the pre-harvest interval, the maximum threshold allowed for olives. As regards residues in olive oil, rotenone was found in concentrations higher than those detected in olives. Copper accumulated in olives according to the number of applications, whereas, in oil, the residue was always lower than the maximum residue limit. The sensitivity of the method applied did not allow detection of azadirachtin. [ABSTRACT FROM AUTHOR]

Published
2009
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24. Progress of the feasibility studies of the European Light Ion Medical Accelerator

Author

Mandrillon, P., Carli, C., Cesari, G., Farley, F. J. M., Fiétier, Nicolas, Ostojic, R., Rocher, C., Dubois, R., and Lefevre, P.

Abstract

A status report on the feasibility studies for the EULIMA medical accelerator project is given. Recent advances in the assessment of the various basic accelerator types ofr the facility are presented in terms of their advantages for heavy ion beam acceleration. Details of the technical studies of various critical subsystems for the superconducting separated sector cyclotron are also presented.

36. Progress towards Sustainable Control of Xylella fastidiosa subsp. pauca in Olive Groves of Salento (Apulia, Italy)

Author

Michael Christian Oehl, Chiara Roberta Girelli, Monica De Caroli, Nicoletta Pucci, Stefania Loreti, Valeria Scala, Marco Scortichini, Laura Del Coco, Peter Hertl, Federica Angilè, Gianluigi Cesari, Francesco Paolo Fanizzi, Dimitri Verweire, Giuseppe Dalessandro, Giuseppe Tatulli, Danilo Migoni, Urs Widmer, Josep Massana Codina, Scortichini, Marco, Loreti, Stefania, Pucci, Nicoletta, Scala, Valeria, Tatulli, Giuseppe, Verweire, Dimitri, Oehl, Michael, Widmer, Ur, Massana-Codina, Josep, Hertl, Peter, Cesari, Gianluigi, DE CAROLI, Monica, Angile', Federica, Migoni, Danilo, DEL COCO, Laura, Girelli, CHIARA ROBERTA, Dalessandro, Giuseppe, Fanizzi, Francesco Paolo, Scortichini, M., Loreti, S., Pucci, N., Scala, V., Tatulli, G., Verweire, D., Oehl, M., Widmer, U., Codina, J. M., Hertl, P., Cesari, G., De Caroli, M., Angile, F., Migoni, D., Del Coco, L., Girelli, C. R., Dalessandro, G., and Fanizzi, F. P.

Subjects
0106 biological sciences, 0301 basic medicine, Microbiology (medical), Canopy, Agroecosystem, Review, Biology, 01 natural sciences, 03 medical and health sciences, olive quick decline syndrome, Confocal laser scanning microscopy, Immunology and Allergy, Cultivar, Molecular Biology, endotherapy, General Immunology and Microbiology, Sustainable strategy, Xylem, Cell concentration, biology.organism_classification, Horticulture, NMR metabolomic, 030104 developmental biology, Infectious Diseases, Endotherapy, NMR metabolomic, Olive quick decline syndrome, Real time PCR, Sustainable development goals of the United Nations, Medicine, Xylella fastidiosa, real-time PCR, sustainable development goals of the United Nations, 010606 plant biology & botany
Abstract

Xylella fastidiosa subsp. pauca is the causal agent of “olive quick decline syndrome” in Salento (Apulia, Italy). On April 2015, we started interdisciplinary studies to provide a sustainable control strategy for this pathogen that threatens the multi-millennial olive agroecosystem of Salento. Confocal laser scanning microscopy and fluorescence quantification showed that a zinc-copper-citric acid biocomplex—Dentamet®—reached the olive xylem tissue either after the spraying of the canopy or injection into the trunk, demonstrating its effective systemicity. The biocomplex showed in vitro bactericidal activity towards all X. fastidiosa subspecies. A mid-term evaluation of the control strategy performed in some olive groves of Salento indicated that this biocomplex significantly reduced both the symptoms and X. f. subsp. pauca cell concentration within the leaves of the local cultivars Ogliarola salentina and Cellina di Nardò. The treated trees started again to yield. A 1H-NMR metabolomic approach revealed, upon the treatments, a consistent increase in malic acid and γ-aminobutyrate for Ogliarola salentina and Cellina di Nardò trees, respectively. A novel endotherapy technique allowed injection of Dentamet® at low pressure directly into the vascular system of the tree and is currently under study for the promotion of resprouting in severely attacked trees. There are currently more than 700 ha of olive groves in Salento where this strategy is being applied to control X. f. subsp. pauca. These results collectively demonstrate an efficient, simple, low-cost, and environmentally sustainable strategy to control this pathogen in Salento.

Published
2021

37. SuperB Progress Reports -- Detector

Author

M. Baszczyk, P. Dorosz, J. Kolodziej, W. Kucewicz, M. Sapor, A. Jeremie, E. Grauges Pous, G. E. Bruno, G. De Robertis, D. Diacono, G. Donvito, P. Fusco, F. Gargano, F. Giordano, F. Loddo, F. Loparco, G. P. Maggi, V. Manzari, M. N. Mazziotta, E. Nappi, A. Palano, B. Santeramo, I. Sgura, L. Silvestris, V. Spinoso, G. Eigen, J. Zalieckas, Z. Zhu, L. Jenkovszky, G. Balbi, M. Boldini, D. Bonacorsi, V. Cafaro, I. D'Antone, G. M. Dallavalle, R. Di Sipio, F. Fabbri, L. Fabbri, A. Gabrielli, D. Galli, P. Giacomelli, V. Giordano, F. M. Giorgi, C. Grandi, I. Lax, S. Lo Meo, U. Marconi, A. Montanari, G. Pellegrini, M. Piccinini, T. Rovelli, N. Semprini Cesari, G. Torromeo, N. Tosi, R. Travaglini, V. M. Vagnoni, S. Valentinetti, M. Villa, A. Zoccoli, J. F. Caron, C. Hearty, P. F. T. Lu, T. S. Mattison, J. A. McKenna, R. Y. C. So, M. Y.u. Barnyakov, V. E. Blinov, A. A. Botov, V. P. Druzhinin, V. B. Golubev, S. A. Kononov, E. A. Kravchenko, E. B. Levichev, A. P. Onuchin, S. I. Serednyakov, D. A. Shtol, Y. I. Skovpen, E. P. Solodov, A. Cardini, M. Carpinelli, D. S. T. Chao, C. H. Cheng, D. A. Doll, B. Echenard, K. Flood, J. Hanson, D. G. Hitlin, P. Ongmongkolkul, F. C. Porter, R. Y. Zhu, N. Randazzo, E. De La Cruz Burelo, Y. Zheng, P. Campos, M. De Silva, A. Kathirgamaraju, B. Meadows, B. Pushpawela, Y. Shi, M. Sokoloff, G. Lopez Castro, V. Ciaschini, P. Franchini, F. Giacomini, A. Paolini, G. A. Calderon Polania, S. Laczek, P. Romanowicz, B. Szybinski, M. Czuchry, L. Flis, D. Harezlak, J. Kocot, M. Radecki, M. Sterzel, T. Szepieniec, T. Szymocha, P. Wójcik, M. Andreotti, W. Baldini, R. Calabrese, V. Carassiti, G. Cibinetto, A. Cotta Ramusino, F. Evangelisti, A. Gianoli, E. Luppi, R. Malaguti, M. Manzali, M. Melchiorri, M. Munerato, C. Padoan, V. Santoro, L. Tomassetti, M. M. Beretta, M. Biagini, M. Boscolo, E. Capitolo, R. de Sangro, M. Esposito, G. Felici, G. Finocchiaro, M. Gatta, C. Gatti, S. Guiducci, S. Lauciani, P. Patteri, I. Peruzzi, M. Piccolo, P. Raimondi, M. Rama, C. Sanelli, S. Tomassini, P. Fabbricatore, D. Delepine, M. A. Reyes Santos, M. Chrzaszcz, R. Grzymkowski, P. Knap, J. Kotula, T. Lesiak, J. Ludwin, J. Michalowski, B. Pawlik, B. Rachwal, M. Stodulski, J. Wiechczynski, M. Witek, L. Zawiejski, M. Zdybal, V. Y. Aushev, A. Ustynov, N. Arnaud, P. Bambade, C. Beigbeder, F. Bogard, M. Borsato, D. Breton, J. Brossard, L. Burmistrov, D. Charlet, V. Chaumat, O. Dadoun, M. El Berni, J. Maalmi, V. Puill, C. Rimbault, A. Stocchi, V. Tocut, A. Variola, S. Wallon, G. Wormser, F. Grancagnolo, E. Ben Haim, S. Sitt, M. Baylac, O. Bourrion, J. M. Deconto, Y. Gomez Martinez, N. Monseu, J. F. Muraz, J. S. Real, C. Vescovi, R. Cenci, A. Jawahery, D. Roberts, E. W. Twedt, R. Cheaib, D. Lindemann, S. Nderitu, P. Patel, S. H. Robertson, D. Swersky, A. Warburton, E. Cuautle Flores, G. Toledo Sanchez, P. Biassoni, L. Bombelli, M. Citterio, S. Coelli, C. Fiorini, V. Liberali, M. Monti, B. Nasri, N. Neri, F. Palombo, F. Sabatini, A. Stabile, A. Berra, A. Giachero, C. Gotti, D. Lietti, M. Maino, G. Pessina, M. Prest, J. P. Martin, M. Simard, N. Starinski, P. Taras, A. Drutskoy, S. Makarychev, A. V. Nefediev, A. Aloisio, G. De Nard, DELLA PIETRA, MASSIMO, A. Doria, GIORDANO, RAFFAELE, A. Ordine, S. Pardi, RUSSO, GUIDO, C. Sciacca, I. I. Bigi, C. P. Jessop, W. Wang, M. Bellato, M. Benettoni, M. Corvo, A. Crescente, F. Dal Corso, U. Dosselli, C. Fanin, A. Gianelle, S. Longo, M. Michelotto, F. Montecassiano, M. Morandin, R. Pengo, M. Posocco, M. Rotondo, G. Simi, R. Stroili, L. Gaioni, A. Manazza, M. Manghisoni, L. Ratti, V. Re, G. Traversi, S. Zucca, S. Bizzaglia, M. Bizzarri, C. Cecchi, S. Germani, M. Lebeau, P. Lubrano, E. Manoni, A. Papi, A. Rossi, G. Scolieri, G. Batignani, S. Bettarini, G. Casarosa, A. Cervelli, A. Fella, F. Forti, M. Giorgi, L. Lilli, A. Lusiani, B. Oberhof, A. Paladino, F. Pantaleo, E. Paoloni, A. L. Perez Perez, G. Rizzo, J. Walsh, A. Fernández Téllez, G. Beck, M. Berman, A. Bevan, F. Gannaway, G. Inguglia, A. J. Martin, J. Morris, V. Bocci, M. Capodiferro, G. Chiodi, I. Dafinei, N. V. Drenska, R. Faccini, F. Ferroni, C. Gargiulo, P. Gauzzi, C. Luci, R. Lunadei, G. Martellotti, F. Pellegrino, V. Pettinacci, D. Pinci, L. Recchia, D. Ruggeri, A. Zullo, P. Camarri, R. Cardarelli, C. De Santis, A. Di Ciaccio, V. Di Felice, F. Di Palma, A. Di Simone, L. Marcelli, R. Messi, D. Moricciani, R. Sparvoli, S. Tammaro, P. Branchini, A. Budano, S. Bussino, M. Ciuchini, F. Nguyen, A. Passeri, F. Ruggieri, E. Spiriti, F. Wilson, I. Leon Monzon, J. R. Millan Almaraz, P. L. M. Podesta Lerma, D. Aston, B. Dey, A. Fisher, P. D. Jackson, D. W. G. S. Leith, S. Luitz, D. MacFarlane, M. McCulloch, S. Metcalfe, A. Novokhatski, S. Osier, R. Prepost, B. Ratcliff, J. Seeman, M. Sullivan, J. Va'vra, U. Wienands, W. Wisniewski, B. D. Altschul, M. V. Purohit, J. Baudot, I. Ripp Baudot, G. A. P. Cirrone, G. Cuttone, O. Bezshyyko, G. Dolinska, A. Soffer, F. Bianchi, F. De Mori, A. Filippi, D. Gamba, S. Marcello, M. Bomben, L. Bosisio, P. Cristaudo, L. Lanceri, B. Liberti, I. Rashevskaya, C. Stella, E. S. Vallazza, L. Vitale, G. Auriemma, C. Satriano, F. Martinez Vidal, J. Mazorra de Cos, A. Oyanguren, P. Ruiz Valls, A. Beaulieu, S. Dejong, J. Franta, M. J. Lewczuk, M. Roney, R. Sobie, CAVALIERE, SERGIO, M. Baszczyk , P. Dorosz, J. Kolodziej, W. Kucewicz, M. Sapor, A. Jeremie, E. Grauges Pous, G.E. Bruno, G. De Robertis, D. Diacono, G. Donvito, P. Fusco, F. Gargano, F. Giordano, F. Loddo, F. Loparco, G.P. Maggi, V. Manzari, M.N. Mazziotta, E. Nappi, A. Palano, B. Santeramo, I. Sgura, L. Silvestris, V. Spinoso, G. Eigen, J. Zalieckas, Z. Zhu, L. Jenkovszky, G. Balbi, M. Boldini, D. Bonacorsi, V. Cafaro, I. D'Antone, G.M. Dallavalle , R. Di Sipio, F. Fabbri, L. Fabbri, A. Gabrielli, D. Galli , P. Giacomelli, V. Giordano, F.M. Giorgi, C. Grandi, I. Lax , S. Lo Meo , U. Marconi, A. Montanari, G. Pellegrini , M. Piccinini, T. Rovelli, N. Semprini Cesari , G. Torromeo , N. Tosi , R. Travaglini, V.M. Vagnoni , S. Valentinetti, M. Villa, A. Zoccoli , J. -F. Caron , C. Hearty, P. F. -T. Lu, T.S. Mattison, J.A. McKenna, R. Y. -C. So , M. Yu. Barnyakov, V.E. Blinov, A.A. Botov, V.P. Druzhinin, V.B. Golubev, S.A. Kononov, E.A. Kravchenko, E.B. Levichev, A.P. Onuchin, S.I. Serednyakov, D.A. Shtol, M., Baszczyk, P., Dorosz, J., Kolodziej, W., Kucewicz, M., Sapor, A., Jeremie, E., Grauges Pou, G. E., Bruno, G., De Roberti, D., Diacono, G., Donvito, P., Fusco, F., Gargano, F., Giordano, F., Loddo, F., Loparco, G. P., Maggi, V., Manzari, M. N., Mazziotta, E., Nappi, A., Palano, B., Santeramo, I., Sgura, L., Silvestri, V., Spinoso, G., Eigen, J., Zaliecka, Z., Zhu, L., Jenkovszky, G., Balbi, M., Boldini, D., Bonacorsi, V., Cafaro, I., D'Antone, G. M., Dallavalle, R., Di Sipio, F., Fabbri, L., Fabbri, A., Gabrielli, D., Galli, P., Giacomelli, V., Giordano, F. M., Giorgi, C., Grandi, I., Lax, S., Lo Meo, U., Marconi, A., Montanari, G., Pellegrini, M., Piccinini, T., Rovelli, N., Semprini Cesari, G., Torromeo, N., Tosi, R., Travaglini, V. M., Vagnoni, S., Valentinetti, M., Villa, A., Zoccoli, J. F., Caron, C., Hearty, P. F. T., Lu, T. S., Mattison, J. A., Mckenna, R. Y. C., So, Barnyakov, M. Y. u., V. E., Blinov, A. A., Botov, V. P., Druzhinin, V. B., Golubev, S. A., Kononov, E. A., Kravchenko, E. B., Levichev, A. P., Onuchin, S. I., Serednyakov, D. A., Shtol, Y. I., Skovpen, E. P., Solodov, A., Cardini, M., Carpinelli, D. S. T., Chao, C. H., Cheng, D. A., Doll, B., Echenard, K., Flood, J., Hanson, D. G., Hitlin, P., Ongmongkolkul, F. C., Porter, R. Y., Zhu, N., Randazzo, E., De La Cruz Burelo, Y., Zheng, P., Campo, M., De Silva, A., Kathirgamaraju, B., Meadow, B., Pushpawela, Y., Shi, M., Sokoloff, G., Lopez Castro, V., Ciaschini, P., Franchini, F., Giacomini, A., Paolini, G. A., Calderon Polania, S., Laczek, P., Romanowicz, B., Szybinski, M., Czuchry, L., Fli, D., Harezlak, J., Kocot, M., Radecki, M., Sterzel, T., Szepieniec, T., Szymocha, P., Wójcik, M., Andreotti, W., Baldini, R., Calabrese, V., Carassiti, G., Cibinetto, A., Cotta Ramusino, F., Evangelisti, A., Gianoli, E., Luppi, R., Malaguti, M., Manzali, M., Melchiorri, M., Munerato, C., Padoan, V., Santoro, L., Tomassetti, M. M., Beretta, M., Biagini, M., Boscolo, E., Capitolo, R., de Sangro, M., Esposito, G., Felici, G., Finocchiaro, M., Gatta, C., Gatti, S., Guiducci, S., Lauciani, P., Patteri, I., Peruzzi, M., Piccolo, P., Raimondi, M., Rama, C., Sanelli, S., Tomassini, P., Fabbricatore, D., Delepine, M. A., Reyes Santo, M., Chrzaszcz, R., Grzymkowski, P., Knap, J., Kotula, T., Lesiak, J., Ludwin, J., Michalowski, B., Pawlik, B., Rachwal, M., Stodulski, J., Wiechczynski, M., Witek, L., Zawiejski, M., Zdybal, V. Y., Aushev, A., Ustynov, N., Arnaud, P., Bambade, C., Beigbeder, F., Bogard, M., Borsato, D., Breton, J., Brossard, L., Burmistrov, D., Charlet, V., Chaumat, O., Dadoun, M., El Berni, J., Maalmi, V., Puill, C., Rimbault, A., Stocchi, V., Tocut, A., Variola, S., Wallon, G., Wormser, F., Grancagnolo, E., Ben Haim, S., Sitt, M., Baylac, O., Bourrion, J. M., Deconto, Y., Gomez Martinez, N., Monseu, J. F., Muraz, J. S., Real, C., Vescovi, R., Cenci, A., Jawahery, D., Robert, E. W., Twedt, R., Cheaib, D., Lindemann, S., Nderitu, P., Patel, S. H., Robertson, D., Swersky, A., Warburton, E., Cuautle Flore, G., Toledo Sanchez, P., Biassoni, L., Bombelli, M., Citterio, S., Coelli, C., Fiorini, V., Liberali, M., Monti, B., Nasri, N., Neri, F., Palombo, F., Sabatini, A., Stabile, A., Berra, A., Giachero, C., Gotti, D., Lietti, M., Maino, G., Pessina, M., Prest, J. P., Martin, M., Simard, N., Starinski, P., Tara, A., Drutskoy, S., Makarychev, A. V., Nefediev, A., Aloisio, Cavaliere, Sergio, G., De Nard, DELLA PIETRA, Massimo, A., Doria, Giordano, Raffaele, A., Ordine, S., Pardi, Russo, Guido, C., Sciacca, I. I., Bigi, C. P., Jessop, W., Wang, M., Bellato, M., Benettoni, M., Corvo, A., Crescente, F., Dal Corso, U., Dosselli, C., Fanin, A., Gianelle, S., Longo, M., Michelotto, F., Montecassiano, M., Morandin, R., Pengo, M., Posocco, M., Rotondo, G., Simi, R., Stroili, L., Gaioni, A., Manazza, M., Manghisoni, L., Ratti, V., Re, G., Traversi, S., Zucca, S., Bizzaglia, M., Bizzarri, C., Cecchi, S., Germani, M., Lebeau, P., Lubrano, E., Manoni, A., Papi, A., Rossi, G., Scolieri, G., Batignani, S., Bettarini, G., Casarosa, A., Cervelli, A., Fella, F., Forti, M., Giorgi, L., Lilli, A., Lusiani, B., Oberhof, A., Paladino, F., Pantaleo, E., Paoloni, A. L., Perez Perez, G., Rizzo, J., Walsh, A., Fernández Téllez, G., Beck, M., Berman, A., Bevan, F., Gannaway, G., Inguglia, A. J., Martin, J., Morri, V., Bocci, M., Capodiferro, G., Chiodi, I., Dafinei, N. V., Drenska, R., Faccini, F., Ferroni, C., Gargiulo, P., Gauzzi, C., Luci, R., Lunadei, G., Martellotti, F., Pellegrino, V., Pettinacci, D., Pinci, L., Recchia, D., Ruggeri, A., Zullo, P., Camarri, R., Cardarelli, C., De Santi, A., Di Ciaccio, V., Di Felice, F., Di Palma, A., Di Simone, L., Marcelli, R., Messi, D., Moricciani, R., Sparvoli, S., Tammaro, P., Branchini, A., Budano, S., Bussino, M., Ciuchini, F., Nguyen, A., Passeri, F., Ruggieri, E., Spiriti, F., Wilson, I., Leon Monzon, J. R., Millan Almaraz, P. L. M., Podesta Lerma, D., Aston, B., Dey, A., Fisher, P. D., Jackson, D. W. G. S., Leith, S., Luitz, D., Macfarlane, M., Mcculloch, S., Metcalfe, A., Novokhatski, S., Osier, R., Prepost, B., Ratcliff, J., Seeman, M., Sullivan, J., Va'Vra, U., Wienand, W., Wisniewski, B. D., Altschul, M. V., Purohit, J., Baudot, I., Ripp Baudot, G. A. P., Cirrone, G., Cuttone, O., Bezshyyko, G., Dolinska, A., Soffer, F., Bianchi, F., De Mori, A., Filippi, D., Gamba, S., Marcello, M., Bomben, L., Bosisio, P., Cristaudo, L., Lanceri, B., Liberti, I., Rashevskaya, C., Stella, E. S., Vallazza, L., Vitale, G., Auriemma, C., Satriano, F., Martinez Vidal, J., Mazorra de Co, A., Oyanguren, P., Ruiz Vall, A., Beaulieu, S., Dejong, J., Franta, M. J., Lewczuk, M., Roney, R., Sobie, Universitat Autònoma de Barcelona (UAB), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratori Nazionali di Frascati (LNF), Istituto Nazionale di Fisica Nucleare (INFN), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), SLAC National Accelerator Laboratory (SLAC), Stanford University, SuperB, and Starita, Sabine

Subjects
[PHYS.HEXP] Physics [physics]/High Energy Physics - Experiment [hep-ex], [PHYS.PHYS.PHYS-INS-DET] Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det]
Abstract

95 pages, 48 pdf figures; This report describes the present status of the detector design for SuperB. It is one of four separate progress reports that, taken collectively, describe progress made on the SuperB Project since the publication of the SuperB Conceptual Design Report in 2007 and the Proceedings of SuperB Workshop VI in Valencia in 2008. The other three reports relate to Physics, Accelerator and Computing.

Published
2010

38. Development and validation of a self-reported questionnaire on users' opinions about schizophrenia: a participatory research

Author

Heidegret Del Vecchio, Rosa D'ambrogio, Andrea Fiorillo, Carla Bachelet, Rosaria Pioli, Paola Zanus, Claudio Malangone, Francesca Fulgosi Cigala, Lorenza Magliano, Mario Maj, Franco Veltro, Giampiero Cesari, Corrado De Rosa, Magliano, Lorenza, Fiorillo, Andrea, DEL VECCHIO, H, Malangone, C, DE ROSA, C, Bachelet, C, Cesari, G, D'Ambrogio, R, Cigala, Ff, Veltro, F, Zanus, P, Pioli, R, and Maj, Mario

Subjects
Adult, Male, medicine.medical_specialty, Psychometrics, Schizophrenia (object-oriented programming), Construct validity, Test validity, behavioral disciplines and activities, beliefs, schizophrenia, patients, Psychiatry and Mental health, Cronbach's alpha, Surveys and Questionnaires, medicine, Content validity, Humans, Female, Schizophrenic Psychology, Patient Participation, Psychiatry, Psychology, Psychosocial, Attitude to Health, Face validity
Abstract

Background: Although users’ involvement in mental health research has repeatedly been acknowledged as having a positive influence on research quality, this rarely happens.Aims: To develop and validate a Questionnaire on Users’ Opinions (QOU) about schizophrenia, in close collaboration with 279 persons affected by this disorder.Methods: A preliminary list of items concerning the opinions of users with schizophrenia regarding causes, treatments and psychosocial consequences of the disorder was developed by 38 users with schizophrenia and 40 professionals who attended a workshop. Psychometric properties of the QOU were tested on 241 users with schizophrenia, 149 of whom were randomly assigned to a test—retest study and 92 to a face-validity study. Content and construct validity were explored in the whole sample.Results: The final version of the QOU contains: (1) 24 items on the psychosocial consequences of schizophrenia, grouped into six subscales, whose Cronbach’s alpha ranged between 0.55 and 0.74; (2) five multiple choice items on the Italian psychiatric law; (3) 12 open questions; and (4) four yes/no skipping items. Items’ reliability, measured by Cohen’s kappa coefficient, ranged between 0.55 and 0.92.Conclusion: This questionnaire may be useful to assess patients’ beliefs about schizophrenia and to target psychosocial interventions for this mental disorder.

Published
2009

41. Long-Term Impairment of Working Ability in Subjects under 60 Years of Age Hospitalised for COVID-19 at 2 Years of Follow-Up: A Cross-Sectional Study.

Author

Frallonardo L, Ritacco AI, Amendolara A, Cassano D, Manco Cesari G, Lugli A, Cormio M, De Filippis M, Romita G, Guido G, Piccolomo L, Giliberti V, Cavallin F, Segala FV, Di Gennaro F, and Saracino A

Subjects
Humans, Cross-Sectional Studies, Male, Female, Middle Aged, Adult, Italy epidemiology, Follow-Up Studies, Post-Acute COVID-19 Syndrome, Prevalence, COVID-19 epidemiology, COVID-19 virology, Hospitalization statistics & numerical data, SARS-CoV-2
Abstract

Background: Coronavirus disease 2019 (COVID-19) can lead to persistent and debilitating symptoms referred to as Post-Acute sequelae of SARS-CoV-2 infection (PASC) This broad symptomatology lasts for months after the acute infection and impacts physical and mental health and everyday functioning. In the present study, we aimed to evaluate the prevalence and predictors of long-term impairment of working ability in non-elderly people hospitalised for COVID-19. Methods: This cross-sectional study involved 322 subjects hospitalised for COVID-19 from 1 March 2020 to 31 December 2022 in the University Hospital of Bari, Apulia, Italy, enrolled at the time of their hospital discharge and followed-up at a median of 731 days since hospitalization (IQR 466-884). Subjects reporting comparable working ability and those reporting impaired working ability were compared using the Mann-Whitney test (continuous data) and Fisher's test or Chi-Square test (categorical data). Multivariable analysis of impaired working ability was performed using a logistic regression model. Results: Among the 322 subjects who were interviewed, 184 reported comparable working ability (57.1%) and 134 reported impaired working ability (41.6%) compared to the pre-COVID-19 period. Multivariable analysis identified age at hospital admission (OR 1.02, 95% CI 0.99 to 1.04), female sex (OR 1.90, 95% CI 1.18 to 3.08), diabetes (OR 3.73, 95% CI 1.57 to 9.65), receiving oxygen during hospital stay (OR 1.76, 95% CI 1.01 to 3.06), and severe disease (OR 0.51, 95% CI 0.26 to 1.01) as independent predictors of long-term impaired working ability after being hospitalised for COVID-19. Conclusions: Our findings suggest that PASC promotes conditions that could result in decreased working ability and unemployment. These results highlight the significant impact of this syndrome on public health and the global economy, and the need to develop clinical pathways and guidelines for long-term care with specific focus on working impairment.

Published
2024
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42. Cardiac Tuberculosis: A Case Series from Ethiopia, Italy, and Uganda and a Literature Review.

Author

Cotugno S, Guido G, Manco Cesari G, Ictho J, Lochoro P, Amone J, Segala FV, De Vita E, Lattanzio R, Okori S, De Iaco G, Girma A, Sura A, Hessebo ET, Balsemin F, Putoto G, Ronga L, Manenti F, Facci E, Saracino A, and Di Gennaro F

Subjects
Humans, Ethiopia epidemiology, Uganda, Antitubercular Agents therapeutic use, Tuberculosis diagnosis, Tuberculosis drug therapy, Tuberculosis complications, Pericardial Effusion diagnosis, Pericardial Effusion drug therapy, Pericardial Effusion etiology, Mycobacterium tuberculosis
Abstract

Extrapulmonary tuberculosis (TB) is estimated to account for up to 20% of active cases of TB disease, but its prevalence is difficult to ascertain because of the difficulty of diagnosis. Involvement of the heart is uncommon, with constrictive pericarditis being the most common cardiac manifestation. Diagnostic research for cardiac disease is frequently lacking, resulting in a high mortality rate. In addition to direct cardiac involvement, instances of cardiac events during antitubercular therapy are described. This case series describes five cases of TB affecting the heart (cardiac TB) from Italy and high-burden, low-income countries (Ethiopia and Uganda), including a case of Loeffler syndrome manifesting as myocarditis in a patient receiving antitubercular therapy. Our study emphasizes how cardiac TB, rare but important in high-burden areas, is a leading cause of pericardial effusion or pericarditis. Timely diagnosis and a comprehensive approach, including imaging and microbiological tools, are crucial. Implementing high-sensitivity methods and investigating alternative samples, such as detection of tuberculosis lipoarabinomannan or use of the GeneXpert assay with stool, is recommended in TB control programs.

Published
2024
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43. Varicella-Zoster Virus Reactivation and Increased Vascular Risk in People Living with HIV: Data from a Retrospective Cohort Study.

Author

Fiordelisi D, Poliseno M, De Gennaro N, Milano E, Santoro CR, Segala FV, Franco CF, Manco Cesari G, Frallonardo L, Guido G, Metrangolo G, Romita G, Di Gennaro F, and Saracino A

Subjects
Humans, Herpesvirus 3, Human physiology, Retrospective Studies, Herpes Zoster, HIV Infections complications, HIV Infections drug therapy, HIV Infections epidemiology
Abstract

Background: The increased vascular risk associated with varicella-zoster virus (VZV) reactivation is extensively established in the general population. This retrospective cohort study investigates whether this observation holds for People Living with HIV (PLWH), a group already confronting heightened cardiovascular risk., Methods: Among PLWH who initiated antiretroviral therapy (ART) at our center and have been under our care for >24 months since 1st January 2005, individuals with a history of herpes zoster (HZ) were identified, and their features were compared with those of PLWH with no history of HZ. The prevalence of ischemic events (deep venous thrombosis, stroke, and acute myocardial infarction) was calculated and compared using the chi-square test. An odds ratio (O.R.) and a 95% confidence interval (C.I.) for ischemic events following HZ were evaluated through univariate and multivariate logistic regression., Results: Overall, 45/581 PLWH reported HZ. Ischemic events followed HZ significantly more often than not (13% vs. 5%, p = 0.01). Positive serology for both VZV and HZ correlated with increased ischemic risk (O.R. 4.01, 95% C.I. 1.38-11.6, p = 0.01 and O.R. 3.14, 95% C.I. 1.12-7.68, p = 0.02, respectively), though chronic heart disease demonstrated stronger predictive value in multivariate analysis(O.R. 8.68, 95% C.I. 2.49-29.50, p = 0.001)., Conclusions: VZV potentially exacerbates vascular risk in PLWH, particularly in the presence of other predisposing factors. Further research is needed to confirm our data.

Published
2023
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44. Treatment of liver cancer cells with ethyl acetate extract of Crithmum maritimum permits reducing sorafenib dose and toxicity maintaining its efficacy.

Author

Gnocchi D, Castellaneta F, Cesari G, Fiore G, Sabbà C, and Mazzocca A

Subjects
Antineoplastic Agents administration & dosage, Antineoplastic Agents pharmacology, Antineoplastic Agents therapeutic use, Antineoplastic Agents, Phytogenic pharmacology, Apoptosis, Cell Cycle Checkpoints drug effects, Cell Line, Tumor, Cell Proliferation, Drug Synergism, Hep G2 Cells, Humans, Inhibitory Concentration 50, Liver drug effects, Plant Extracts pharmacology, Sorafenib pharmacology, Sorafenib therapeutic use, Antineoplastic Agents, Phytogenic therapeutic use, Apiaceae, Carcinoma, Hepatocellular drug therapy, Liver Neoplasms drug therapy, Phytotherapy, Plant Extracts therapeutic use, Sorafenib administration & dosage
Abstract

Objectives: Hepatocellular carcinoma (HCC) is one of the most frequent tumours worldwide and available drugs are inadequate for therapeutic results and tolerability. Hence, novel effective therapeutic tools with fewer side effects are of paramount importance. We have previously shown that Crithmum maritimum ethyl acetate extract exerts a cytostatic effect in HCC cells. Here, we tested whether C. maritimum ethyl acetate extract in combination with half sorafenib IC50 dose ameliorated efficacy and toxicity of sorafenib in inhibiting liver cancer cell growth. Moreover, we investigated the mechanisms involved., Methods: Two HCC cell lines (Huh7 and HepG2) were treated with C. maritimum ethyl acetate extract and half IC50 sorafenib dose usually employed in vitro. Then, cell proliferation, growth kinetics and cell toxicity were analysed together with an investigation of the cellular mechanisms involved, focusing on cell cycle regulation and apoptosis., Key Findings: Results show that combined treatment with C. maritimum ethyl acetate extract and half IC50 sorafenib dose decreased cell proliferation comparably to full-dose sorafenib without increasing cell toxicity as confirmed by the effect on cell cycle regulation and apoptosis., Conclusions: These results provide scientific support for the possibility of an effective integrative therapeutic approach for HCC with fewer side effects on patients., (© The Author(s) 2021. Published by Oxford University Press on behalf of the Royal Pharmaceutical Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

Published
2021
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45. Progress towards Sustainable Control of Xylella fastidiosa subsp. pauca in Olive Groves of Salento (Apulia, Italy).

Author

Scortichini M, Loreti S, Pucci N, Scala V, Tatulli G, Verweire D, Oehl M, Widmer U, Codina JM, Hertl P, Cesari G, De Caroli M, Angilè F, Migoni D, Del Coco L, Girelli CR, Dalessandro G, and Fanizzi FP

Abstract

Xylella fastidiosa subsp. pauca is the causal agent of "olive quick decline syndrome" in Salento (Apulia, Italy). On April 2015, we started interdisciplinary studies to provide a sustainable control strategy for this pathogen that threatens the multi-millennial olive agroecosystem of Salento. Confocal laser scanning microscopy and fluorescence quantification showed that a zinc-copper-citric acid biocomplex-Dentamet ® -reached the olive xylem tissue either after the spraying of the canopy or injection into the trunk, demonstrating its effective systemicity. The biocomplex showed in vitro bactericidal activity towards all X. fastidiosa subspecies. A mid-term evaluation of the control strategy performed in some olive groves of Salento indicated that this biocomplex significantly reduced both the symptoms and X. f. subsp. pauca cell concentration within the leaves of the local cultivars Ogliarola salentina and Cellina di Nardò. The treated trees started again to yield. A 1 H-NMR metabolomic approach revealed, upon the treatments, a consistent increase in malic acid and γ-aminobutyrate for Ogliarola salentina and Cellina di Nardò trees, respectively. A novel endotherapy technique allowed injection of Dentamet ® at low pressure directly into the vascular system of the tree and is currently under study for the promotion of resprouting in severely attacked trees. There are currently more than 700 ha of olive groves in Salento where this strategy is being applied to control X. f . subsp. pauca . These results collectively demonstrate an efficient, simple, low-cost, and environmentally sustainable strategy to control this pathogen in Salento.

Published
2021
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46. Healthy Lifestyle Management of Pediatric Obesity with a Hybrid System of Customized Mobile Technology: The PediaFit Pilot Project.

Author

Delli Bovi AP, Manco Cesari G, Rocco MC, Di Michele L, Rimauro I, Lugiero A, Mottola S, De Anseris AGE, Nazzaro L, Massa G, and Vajro P

Subjects
Adolescent, Child, Exercise, Female, Humans, Male, Pilot Projects, Diet, Healthy, Healthy Lifestyle, Pediatric Obesity therapy, Text Messaging, Weight Reduction Programs
Abstract

Pediatric obesity management strategies suffer from a high rate of dropout and persistence of weight excess, despite the use of new tools, such as automated mobile technology (MT). We aimed to compare the efficacy of two 6-month personalized MT protocols in terms of better engagement, adherence to follow-up visits and improved anthropometric and lifestyle parameters. MT contacts consisted of three personalized/not automated What's App ® self-monitoring or challenge messages per week. Messages, sent by a dedicated coach were inserted between three-monthly in-presence regular visits with (PediaFit 1.2) or without (PediaFit 1.1) monthly free-of charge short recall visits carried out by a specialized pediatric team. The sample included 103 children (mean age 10 years, range 6-14) recruited in the Pediatric Obesity Clinic between January 2017 and February 2019, randomized into Intervention group (IG) ( n = 24 PediaFit 1.1; n = 30 PediaFit 1.2) and Control group (CG) (total n = 49). Controls received standard treatment only (indications for healthy nutrition and physical activity, and three months in presence regular visits). Overall, both IGs achieved significantly better results than the CGs for all considered parameters. Comparison of the two IGs at the sixth month in particular showed an IG 1.2 statistically significantly lower drop-out rate (10% vs. 62%, p = 0.00009), along with significantly improved BMI ( p = 0.003), Screen Time ( p = 0.04) and fruit and vegetables consumption ( p = 0.02). The study suggests that the hybrid association of messaging through personalized/not automated MT plus monthly free-of charge recall visits may improve the prefixed outcomes of MT weight loss intervention programs.

Published
2021
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47. 1 H-NMR metabolomics reveals a multitarget action of Crithmum maritimum ethyl acetate extract in inhibiting hepatocellular carcinoma cell growth.

Author

Gnocchi D, Del Coco L, Girelli CR, Castellaneta F, Cesari G, Sabbà C, Fanizzi FP, and Mazzocca A

Subjects
Hep G2 Cells, Humans, Metabolomics, Nuclear Magnetic Resonance, Biomolecular, Acetates chemistry, Antineoplastic Agents, Phytogenic chemistry, Antineoplastic Agents, Phytogenic pharmacology, Apiaceae chemistry, Carcinoma, Hepatocellular drug therapy, Carcinoma, Hepatocellular metabolism, Carcinoma, Hepatocellular pathology, Cell Proliferation drug effects, Liver Neoplasms drug therapy, Liver Neoplasms metabolism, Liver Neoplasms pathology, Plant Extracts chemistry, Plant Extracts pharmacology
Abstract

Hepatocellular carcinoma (HCC) is nowadays the sixth cause of tumour-related deceases worldwide, estimated to become the third in Western countries by 2030. New drugs for HCC treatment still have many adverse effects. Several lines of evidence indicate that plant metabolites offer concrete opportunities for developing new therapeutic strategies for many diseases, including cancer. We previously reported that ethyl acetate extract of a spontaneous edible plant harvested in Apulia, Crithmum maritimum, significantly inhibited cell growth in HCC cells. By 1 H-NMR spectroscopy, here we show that Crithmum maritimum ethyl acetate extract counteracts the Warburg effect, by reducing intracellular lactate, inhibits protein anabolism, by decreasing amino acid level, and affects membrane biosynthesis by lowering choline and phosphocholine. Also, we observed an effect on lipid homeostasis, with a reduction in triglycerides, cholesterol, monounsaturated fatty acids (MUFA), and diunsaturated fatty acids (DUFA), and an increase in polyunsaturated fatty acids (PUFA). Taken together, these data demonstrate that Crithmum maritimum-induced cytostasis is exerted through a multi-effect action, targeting key metabolic processes in HCC cells. Overall, our findings highlight the role of Crithmum maritimum as a promising tool for the prevention and the improvement of the therapeutic options for HCC and other types of tumours.

Published
2021
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48. Inhibition of Hepatocellular Carcinoma Growth by Ethyl Acetate Extracts of Apulian Brassica oleracea L. and Crithmum maritimum L.

Author

Gnocchi D, Cesari G, Calabrese GJ, Capone R, Sabbà C, and Mazzocca A

Subjects
Acetates, Humans, Plant Extracts, Brassica, Carcinoma, Hepatocellular, Liver Neoplasms
Abstract

Nowadays, a growing body of evidence supports the view that plants offer an extraordinary opportunity to discover and develop new promising therapeutic strategies for many diseases, including cancer. Here we tested the anticancer action against Hepatocellular carcinoma (HCC) of extracts obtained from two plants harvested in Apulia, namely Brassica oleracea L. and Crithmum maritimum L. B. oleracea was grown in biodynamical agriculture without any agrochemical input, instead C. maritimum was collected on Apulian coasts and is still commonly eaten in Apulia. HCC, one of the most frequent tumors worldwide, is estimated to become the third leading cause of cancer-related deaths in Western Countries by 2030. The approved synthetic drugs for the treatment of HCC are currently inadequate in terms of therapeutic results and tolerability. Hence, aim of the present study was to test the anticancer action against HCC of extracts obtained from Brassica oleracea L. and Crithmum maritimum L. We preliminary prepared extracts from both plants using four solvents with different polarity: hexane, ethyl acetate, methanol and ethanol. Then, we tested the effect of the different fractions in inhibiting HCC cell growth. Finally, we characterized the mechanism of action of the most effective fraction. We found that ethyl acetate fractions from both plants were the most effective in inhibiting HCC growth. In particular, we demonstrated that these fractions effectively reduce HCC growth by exerting, on one hand, a cytostatic effect through their action on the cell cycle, and on the other hand by triggering apoptosis and necrosis. Our findings support the notion that ethyl acetate fractions from Apulian B. oleracea and C. maritimum can be in perspective considered as promising tools to expand the opportunities to identify new and not toxic anticancer therapeutic approaches for HCC. Further pharmacological investigations will shed light on how this could be effectively achieved. Graphical Abstract Experimental workflow for the detection of the ethyl acetate extract of Brassica oleracea L. and Crithmum maritimum L. as an active fraction in inhibiting HCC cell growth.

Published
2020
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49. An Evaluation of Monitoring Surveys of the Quarantine Bacterium Xylella Fastidiosa Performed in Containment and Buffer Areas of Apulia, Southern Italy.

Author

Scortichini M and Cesari G

Abstract

Introduction: Xylella fastidiosa is a quarantine phytopathogen for the European Plant Protection Organization and currently infects olive trees in the Apulia region (southern Italy). Upon the Implementing Decision of the European Union 2016/764 of May 12, 2016, extensive monitoring surveys were performed on approximately 190 000 ha to ascertain the possible occurrence of X. fastidiosa ., Objectives: The primary objectives of the analysis were to start to collect epidemiological data on X. fastidiosa occurrence in areas far from the initial outbreaks and discuss the results of the pathogen detection., Methods: A total of 220 279 olive trees were inspected. Basic information on farm and trees management was obtained. A total of 13 706 olive trees were analyzed through serological and molecular techniques to verify the possible occurrence of the bacterium., Results: The cultivars "Nociara," "Cima di Melfi," and "Cellina di Nardò" showed the highest occurrence of decline symptoms. Tree age appears to be related to the incidence of decline symptoms. Olive trees growing in well-managed soils showed fewer symptoms than trees cultivated in farms where such agronomic techniques are not regularly performed. X. fastidiosa was detected in 2078 samples taken from symptomatic trees and 1653 samples obtained from asymptomatic trees. In 3300 samples taken from symptomatic trees, the bacterium was not detected., Conclusions: Implementation and utilization of reliable in situ detection techniques could increase the number of sampled trees in each plot, thus allowing a more extensive and robust assessment of X. fastidiosa -infected plants in areas where the pathogen inoculums are still low., Competing Interests: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article., (© ABSA International 2019.)

Published
2019
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50. An application of the Shapley value to the analysis of co-expression networks.

Author

Cesari G, Algaba E, Moretti S, and Nepomuceno JA

Abstract

We study the problem of identifying relevant genes in a co-expression network using a (cooperative) game theoretic approach. The Shapley value of a cooperative game is used to asses the relevance of each gene in interaction with the others, and to stress the role of nodes in the periphery of a co-expression network for the regulation of complex biological pathways of interest. An application of the method to the analysis of gene expression data from microarrays is presented, as well as a comparison with classical centrality indices. Finally, making further assumptions about the a priori importance of genes, we combine the game theoretic model with other techniques from cluster analysis., Competing Interests: The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Published
2018
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