23,298 results on '"CEREZO"'
Search Results
2. Advances in the Physiology of Transvascular Exchange and A New Look At Rational Fluid Prescription
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Alamilla-Sanchez ME, Alcala-Salgado MA, Cerezo Samperio B, Prado Lozano P, Diaz Garcia JD, Gonzalez Fuentes C, Yama Estrella MB, and Morales Lopez EF
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starling principle ,transvascular exchange ,glycocalyx ,capillary refilling ,volume kinetics ,Medicine (General) ,R5-920 - Abstract
Mario E Alamilla-Sanchez,1 Miguel A Alcala-Salgado,2 Beatriz Cerezo Samperio,1 Pamela Prado Lozano,1 Juan Daniel Diaz Garcia,1 Carolina Gonzalez Fuentes,1 Martin Benjamin Yama Estrella,1 Enrique Fleuvier Morales Lopez1 1Department of Nephrology, Centro Medico Nacional “ 20 de Noviembre”, Mexico City, Mexico; 2Department of Nephrology, Hospital “Christus Muguerza”, Saltillo, Coahuila, MexicoCorrespondence: Mario E Alamilla-Sanchez, Tel +52 5541334931, Email silenoz1@hotmail.comAbstract: The Starling principle is a model that explains the transvascular distribution of fluids essentially governed by hydrostatic and oncotic forces, which dynamically allow vascular refilling according to the characteristics of the blood vessel. However, careful analysis of fluid physiology has shown that the principle, while correct, is not complete. The revised Starling principle (Michel-Weinbaum model) provides relevant information on fluid kinetics. Special emphasis has been placed on the endothelial glycocalyx, whose subendothelial area allows a restricted oncotic pressure that limits the reabsorption of fluid from the interstitial space, so that transvascular refilling occurs mainly from the lymphatic vessels. The close correlation between pathological states of the endothelium (eg: sepsis, acute inflammation, or chronic kidney disease) and the prescription of fluids forces the physician to understand the dynamics of fluids in the organism; this will allow rational fluid prescriptions. A theory that integrates the physiology of exchange and transvascular refilling is the “microconstant model”, whose variables include dynamic mechanisms that can explain edematous states, management of acute resuscitation, and type of fluids for common clinical conditions. The clinical-physiological integration of the concepts will be the hinges that allow a rational and dynamic prescription of fluids.Keywords: Starling principle, transvascular exchange, glycocalyx, capillary refilling, volume kinetics
- Published
- 2023
3. Life E-VIA: Prototypal Low-Noise Road Surface for the Reduction of Electric Vehicle Rolling Noise in Urban Area
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Pallas Marie-Agnès, Cesbron Julien, Bianchetti Simon, Klein Philippe, Cerezo Véronique, Augris Pierre, Ropert Christophe, Praticò Filippo G., and Bianco Francesco
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electric vehicle ,road surface ,tyre/road noise ,urban road traffic noise ,friction ,Transportation engineering ,TA1001-1280 - Abstract
In both the current and foreseen context of significant development of the electric vehicle (EV) fleet, a future increasing ratio of EVs in the urban traffic is expected, still enhanced in low-emission zones involving bans or restricted access to other vehicles. EVs are known to be quieter than conventional vehicles at low speed because of a low motor noise emission, resulting in a higher prevalence of rolling noise in the environmental noise. EVs differ from conventional vehicles in several parameters that can influence tyre/road noise, like weight and torque. The LIFE E-VIA project objectives consist in developing, implementing and assessing a low-noise road surface for light EV traffic in urban conditions, optimised from an acoustical and life cycle perspective. In parallel, an optimisation of EV tyres is investigated.
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- 2022
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4. Síndrome Compartimental em Envenenamento por mordedura de serpente Bitis arietans em Angola: caso clínico
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Paula Oliveira, Nelson Baldaia, Jéssica Campos, and Cerezo Hossior Gaspar
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Síndrome compartimental ,mordedura de serpente ,Bitis arietans ,Medicine - Abstract
Introdução: O envenenamento por mordedura de serpentes constitui uma séria condição médica e uma emergência médico-cirúrgica frequente, que afecta, primariamente, as comunidades rurais de África, América Latina, Ásia e Nova Guiné. Causam um número elevado de vítimas que podem evoluir para morte, ou debilidades físicas permanentes. Em toda África Austral e Oriental, a Bitis arietans é responsável pela maioria dos casos de envenenamento grave e morte. Objetivos: Apresentar o primeiro caso clínico de síndrome compartimental por mordedura de Bitis arietans em Angola. Material e Métodos: Tratou-se de uma caso clínico, de um indivíduo do sexo masculino, de 42 anos, natural da (Província do Bengo), que foi vítima de mordedura de uma serpente identificada por fotografia como sendo (Bitis arietans) no dorso da mão direita entre o polegar e o indicador, por volta das 19h00 do dia 15/09/2022, com abordagem médica inicial no Hospital do Bengo, onde foi feita reposição volêmica com solução salina a 0,9% e posteriormente transferido para o banco de urgência do Hospital Militar Principal onde chegou por volta das 21h00. Resultados: O paciente apresentou síndrome compartimental do membro superior direito e sangramento profuso do local da picada com lesões flectenulares ao nível do antebraço, limitação dos movimentos e doloroso à palpação. Polegar com lesão puntiforme sangrante e pele enegrecida, tórax assimétrico a custa de aumento de volume da região peitoral direita, doloroso à palpação e sem enfisema subcutâneo. Após um período de 92 dias de internamento hospitalar, foi submetido a 9 cirurgias, evoluiu satisfatoriamente apesar de estadia prolongada, tendo-se feito a aproximação cirúrgica dos bordos da ferida cirúrgica e se decidido alta hospitalar com seguimento em consulta de Cirurgia. Conclusões: O espectro multivariado de complicações clínicas desenvolvidas e apresentadas neste caso clínico por envenenamento por Bitis arietans demonstra que os acidentes ofídicos possuem características únicas que tornam a sua prevenção e controle desafiadores. A inacessibilidade imediata a cuidados de saúde diferenciados, tendem a aumentar as complicações e a probabilidade de óbito, quando associarmos o facto do soro antiofídico não ser produzido no nosso país e indisponíveis nos hospitais.
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- 2023
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5. Profiling the immune response to Mycobacterium tuberculosis Beijing family infection: a perspective from the transcriptome
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Cerezo-Cortés María Irene, Rodríguez-Castillo Juan Germán, López-Leal Gamaliel, Mata-Espinosa Dulce Adriana, Bini Estela Isabel, Marquina–Casitllo Brenda Nohemí, Barrios Payan Jorge, Zatarain-Barrón Zyanya Lucía, Bobadilla del Valle Myriam, Cornejo-Granados F, Ochoa-Leyva Adrian, Murcia Martha Isabel, and Hernández-Pando Rogelio
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m. tuberculosis ,beijing ,beijing-like ,virulence ,transcriptomics ,immune response ,colombia ,Infectious and parasitic diseases ,RC109-216 - Abstract
Tuberculosis continues to be an important public health problem. Particularly considering Beijing-family strains of Mycobacterium tuberculosis, which have been associated with drug-resistance and hypervirulence. The Beijing-like SIT190 (BL) is the most prevalent Beijing strain in Colombia. The pathogenic mechanism and immune response against this pathogen is unknown. Thus, we compared the course of pulmonary TB in BALB/c mice infected with Classical-Beijing strain 391 and BL strain 323. The disease course was different among infected animals with Classical-Beijing and BL strain. Mice infected with BL had a 100% mortality at 45 days post-infection (dpi), with high bacillary loads and massive pneumonia, whereas infected animals with Classical-Beijing survived until 60 dpi and showed extensive pneumonia and necrosis. Lung RNA extraction was carried out at early (day 3 dpi), intermediate (day 14 dpi), and late (days 28 and 60 dpi) time points of infection. Transcriptional analysis of infected mice with Classical-Beijing showed several over-expressed genes, associated with a pro-inflammatory profile, including those for coding for CCL3 and CCL4 chemokines, both biomarkers of disease severity. Conversely, mice infected with BL displayed a profile which included the over-expression of several genes associated with immune-suppression, including Nkiras, Dleu2, and Sphk2, highlighting an anti-inflammatory milieu which would allow high bacterial replication followed by an intense inflammatory response. In summary, both Beijing strains induced a non-protective immune response which induced extensive tissue damage, BL strain induced rapidly extensive pneumonia and death, whereas Classical-Beijing strain produced slower extensive pneumonia later associated with extensive necrosis. Abbreviations Mtb: Mycobacterium tuberculosis; SIT: Spoligotype International Type; TB: Tuberculosis; CTB: Classical-typical Beijing; BL: Beijing-Like; CCL3: Chemokine (C-C motif) ligand 3 (CCL3); CCL4: Chemokine (C-C motif) ligand four (CCL4); WHO: World health Organization; DR: Direct Repeats; IFN-γ: Interferon Gamma; IL: Interleukin; TGF-β: Transforming Growth Factor Beta; XDR: Extremely Drug Resistant; MDR: Multi Drug Resistant; MIRU-VNTR: Mycobacterial Interspersed Repetitive Units–Variable Number Tandem repeats; OADC: Oleic Albumin Dextrose Catalase; ATCC: American Type Culture Collection; MOI: Multiplicity of Infection; CFUs: Colony Forming Units; ELISA: enzyme-linked immunosorbent assay; qRT-PCR: Real-Time Quantitative Reverse Transcription PCR; RNA-seq: Ribonucleic Acid sequencing; RIN: RNA Integrity Number; RNA: Ribonucleic Acid; DNA: Deoxyribonucleic Acid; dsDNA HS: Double stranded Deoxyribonucleic Acid High Sensitivity; RAI: Red de Apoyo à la Investigacion, Mexico City, Mexico; DEG: Differential Expressed Genes; GO: Gene Ontology; KEGG: Kyoto Encyclopedia of Genes and Genomes; ORA: Over-Representation Analysis; SNPs: Single Nucleotide Polymorphisms; TNFα: Tumoral necrosis factor alpha; DE: Differential Expression; EPA: Enrichment Pathways Analysis; TLR: Toll-Like receptor; NLRP: NOD-like receptor with Pyrin domain; tRNA: Transfer RNA; MAPK: Mitogen-Activated Protein Kinase; NK: Natural killer; ATP: Adenosine Triphosphate; DGC: dystrophin-glycoprotein complex; PDIM: Ptiocerol Dimicocerosate; NCBI: National Center for Bioinformatics Information
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- 2021
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6. Real classical shadows
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West, Maxwell, Mele, Antonio Anna, Larocca, Martin, and Cerezo, M.
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Quantum Physics - Abstract
Efficiently learning expectation values of a quantum state using classical shadow tomography has become a fundamental task in quantum information theory. In a classical shadows protocol, one measures a state in a chosen basis $\mathcal{W}$ after it has evolved under a unitary transformation randomly sampled from a chosen distribution $\mathcal{U}$. In this work we study the case where $\mathcal{U}$ corresponds to either local or global orthogonal Clifford gates, and $\mathcal{W}$ consists of real-valued vectors. Our results show that for various situations of interest, this ``real'' classical shadow protocol improves the sample complexity over the standard scheme based on general Clifford unitaries. For example, when one is interested in estimating the expectation values of arbitrary real-valued observables, global orthogonal Cliffords decrease the required number of samples by a factor of two. More dramatically, for $k$-local observables composed only of real-valued Pauli operators, sampling local orthogonal Cliffords leads to a reduction by an exponential-in-$k$ factor in the sample complexity over local unitary Cliffords. Finally, we show that by measuring in a basis containing complex-valued vectors, orthogonal shadows can, in the limit of large system size, exactly reproduce the original unitary shadows protocol., Comment: 7+12 pages, 1+1 figures
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- 2024
7. Analyzing the quantum approximate optimization algorithm: ans\'atze, symmetries, and Lie algebras
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Kazi, Sujay, Larocca, Martín, Farinati, Marco, Coles, Patrick J., Cerezo, M., and Zeier, Robert
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Quantum Physics - Abstract
The Quantum Approximate Optimization Algorithm (QAOA) has been proposed as a method to obtain approximate solutions for combinatorial optimization tasks. In this work, we study the underlying algebraic properties of three QAOA ans\"atze for the maximum-cut (maxcut) problem on connected graphs, while focusing on the generated Lie algebras as well as their invariant subspaces. Specifically, we analyze the standard QAOA ansatz as well as the orbit and the multi-angle ans\"atze. We are able to fully characterize the Lie algebras of the multi-angle ansatz for arbitrary connected graphs, finding that they only fall into one of just six families. Besides the cycle and the path graphs, dimensions of every graph are exponentially large in the system size, meaning that multi-angle ans\"atze are extremely prone to exhibiting barren plateaus. Then, a similar quasi-graph-independent Lie-algebraic characterization beyond the multi-angle ansatz is impeded as the circuit exhibits additional "hidden" symmetries besides those naturally arising from a certain parity-superselection operator and all automorphisms of the considered graph. Disregarding the "hidden" symmetries, we can upper bound the dimensions of the orbit and the standard Lie algebras, and the dimensions of the associated invariant subspaces are determined via explicit character formulas. To finish, we conjecture that (for most graphs) the standard Lie algebras have only components that are either exponential or that grow, at most, polynomially with the system size. This would imply that the QAOA is either prone to barren plateaus, or classically simulable., Comment: 17+24 pages, 7+7 figures, 4+3 tables, comments and feedback are welcome
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- 2024
8. More buck-per-shot: Why learning trumps mitigation in noisy quantum sensing
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Ijaz, Aroosa, Alderete, C. Huerta, Sauvage, Frédéric, Cincio, Lukasz, Cerezo, M., and Goh, Matthew L.
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Quantum Physics - Abstract
Quantum sensing is one of the most promising applications for quantum technologies. However, reaching the ultimate sensitivities enabled by the laws of quantum mechanics can be a challenging task in realistic scenarios where noise is present. While several strategies have been proposed to deal with the detrimental effects of noise, these come at the cost of an extra shot budget. Given that shots are a precious resource for sensing -- as infinite measurements could lead to infinite precision -- care must be taken to truly guarantee that any shot not being used for sensing is actually leading to some metrological improvement. In this work, we study whether investing shots in error-mitigation, inference techniques, or combinations thereof, can improve the sensitivity of a noisy quantum sensor on a (shot) budget. We present a detailed bias-variance error analysis for various sensing protocols. Our results show that the costs of zero-noise extrapolation techniques outweigh their benefits. We also find that pre-characterizing a quantum sensor via inference techniques leads to the best performance, under the assumption that the sensor is sufficiently stable., Comment: 17+18 pages, 8+2 figures, 1+1 tables
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- 2024
9. Random ensembles of symplectic and unitary states are indistinguishable
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West, Maxwell, Mele, Antonio Anna, Larocca, Martin, and Cerezo, M.
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Quantum Physics ,Computer Science - Computational Complexity ,Computer Science - Information Theory - Abstract
A unitary state $t$-design is an ensemble of pure quantum states whose moments match up to the $t$-th order those of states uniformly sampled from a $d$-dimensional Hilbert space. Typically, unitary state $t$-designs are obtained by evolving some reference pure state with unitaries from an ensemble that forms a design over the unitary group $\mathbb{U}(d)$, as unitary designs induce state designs. However, in this work we study whether Haar random symplectic states -- i.e., states obtained by evolving some reference state with unitaries sampled according to the Haar measure over $\mathbb{SP}(d/2)$ -- form unitary state $t$-designs. Importantly, we recall that random symplectic unitaries fail to be unitary designs for $t>1$, and that, while it is known that symplectic unitaries are universal, this does not imply that their Haar measure leads to a state design. Notably, our main result states that Haar random symplectic states form unitary $t$-designs for all $t$, meaning that their distribution is unconditionally indistinguishable from that of unitary Haar random states, even with tests that use infinite copies of each state. As such, our work showcases the intriguing possibility of creating state $t$-designs using ensembles of unitaries which do not constitute designs over $\mathbb{U}(d)$ themselves, such as ensembles that form $t$-designs over $\mathbb{SP}(d/2)$., Comment: 6+11 pages, 1+1 figures
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- 2024
10. Classically estimating observables of noiseless quantum circuits
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Angrisani, Armando, Schmidhuber, Alexander, Rudolph, Manuel S., Cerezo, M., Holmes, Zoë, and Huang, Hsin-Yuan
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Quantum Physics ,Computer Science - Computational Complexity ,Mathematical Physics - Abstract
We present a classical algorithm for estimating expectation values of arbitrary observables on most quantum circuits across all circuit architectures and depths, including those with all-to-all connectivity. We prove that for any architecture where each circuit layer is equipped with a measure invariant under single-qubit rotations, our algorithm achieves a small error $\varepsilon$ on all circuits except for a small fraction $\delta$. The computational time is polynomial in qubit count and circuit depth for any small constant $\varepsilon, \delta$, and quasi-polynomial for inverse-polynomially small $\varepsilon, \delta$. For non-classically-simulable input states or observables, the expectation values can be estimated by augmenting our algorithm with classical shadows of the relevant state or observable. Our approach leverages a Pauli-path method under Heisenberg evolution. While prior works are limited to noisy quantum circuits, we establish classical simulability in noiseless regimes. Given that most quantum circuits in an architecture exhibit chaotic and locally scrambling behavior, our work demonstrates that estimating observables of such quantum dynamics is classically tractable across all geometries., Comment: Main text: 8 pages, 3 figures. Appendices: 25 pages, 1 figure
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- 2024
11. Quantum Convolutional Neural Networks are (Effectively) Classically Simulable
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Bermejo, Pablo, Braccia, Paolo, Rudolph, Manuel S., Holmes, Zoë, Cincio, Lukasz, and Cerezo, M.
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Quantum Physics ,Computer Science - Machine Learning ,Statistics - Machine Learning - Abstract
Quantum Convolutional Neural Networks (QCNNs) are widely regarded as a promising model for Quantum Machine Learning (QML). In this work we tie their heuristic success to two facts. First, that when randomly initialized, they can only operate on the information encoded in low-bodyness measurements of their input states. And second, that they are commonly benchmarked on "locally-easy'' datasets whose states are precisely classifiable by the information encoded in these low-bodyness observables subspace. We further show that the QCNN's action on this subspace can be efficiently classically simulated by a classical algorithm equipped with Pauli shadows on the dataset. Indeed, we present a shadow-based simulation of QCNNs on up-to $1024$ qubits for phases of matter classification. Our results can then be understood as highlighting a deeper symptom of QML: Models could only be showing heuristic success because they are benchmarked on simple problems, for which their action can be classically simulated. This insight points to the fact that non-trivial datasets are a truly necessary ingredient for moving forward with QML. To finish, we discuss how our results can be extrapolated to classically simulate other architectures., Comment: 11 + 13 pages , 6 + 3 figures, 1 table
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- 2024
12. Exact spectral gaps of random one-dimensional quantum circuits
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Deneris, Andrew E., Bermejo, Pablo, Braccia, Paolo, Cincio, Lukasz, and Cerezo, M.
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Quantum Physics ,Computer Science - Computational Complexity ,Computer Science - Information Theory - Abstract
The spectral gap of local random quantum circuits is a fundamental property that determines how close the moments of the circuit's unitaries match those of a Haar random distribution. When studying spectral gaps, it is common to bound these quantities using tools from statistical mechanics or via quantum information-based inequalities. By focusing on the second moment of one-dimensional unitary circuits where nearest neighboring gates act on sets of qudits (with open and closed boundary conditions), we show that one can exactly compute the associated spectral gaps. Indeed, having access to their functional form allows us to prove several important results, such as the fact that the spectral gap for closed boundary condition is exactly the square of the gap for open boundaries, as well as improve on previously known bounds for approximate design convergence. Finally, we verify our theoretical results by numerically computing the spectral gap for systems of up to 70 qubits, as well as comparing them to gaps of random orthogonal and symplectic circuits., Comment: 9 + 6 pages, 3 figures
- Published
- 2024
13. Gate-based quantum simulation of Gaussian bosonic circuits on exponentially many modes
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Barthe, Alice, Cerezo, M., Sornborger, Andrew T., Larocca, Martin, and García-Martín, Diego
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Quantum Physics ,Computer Science - Computational Complexity - Abstract
We introduce a framework for simulating, on an $(n+1)$-qubit quantum computer, the action of a Gaussian Bosonic (GB) circuit on a state over $2^n$ modes. Specifically, we encode the initial bosonic state's expectation values over quadrature operators (and their covariance matrix) as an input qubit-state. This is then evolved by a quantum circuit that effectively implements the symplectic propagators induced by the GB gates. We find families of GB circuits and initial states leading to efficient quantum simulations. For this purpose, we introduce a dictionary that maps between GB and qubit gates such that particle- (non-particle-) preserving GB gates lead to real (imaginary) time evolutions at the qubit level. For the special case of particle-preserving circuits, we present a BQP-complete GB decision problem, indicating that GB evolutions of Gaussian states on exponentially many modes are as powerful as universal quantum computers. We also perform numerical simulations of an interferometer on $\sim8$ billion modes, illustrating the power of our framework., Comment: 5+14 pages, 3 figures, 1 table
- Published
- 2024
14. Data-Driven Probabilistic Methodology for Aircraft Conflict Detection Under Wind Uncertainty
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de la Mota, Jaime, Cerezo-Magaña, María, Olivares, Alberto, and Staffetti, Ernesto
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Mathematics - Optimization and Control - Abstract
Assuming the availability of a reliable aircraft trajectory planner, this paper presents a probabilistic methodology to detect conflicts between aircraft, in the cruise phase of the flight, in the presence of wind prediction uncertainties quantified by ensemble weather forecasts, which are regarded as realizations of correlated random processes and employed to derive the eastward and northward components of the wind velocity. First, the Karhunen-Lo`eve expansion is used to obtain a series expansion of the wind components in terms of a set of uncorrelated random variables and deterministic coefficients. Then, the uncertainty induced by these uncorrelated random variables in the outputs of the aircraft trajectory planner is quantified by means of the arbitrary polynomial chaos technique. Finally, the probability density function of the great circle distance between each pair of aircraft is derived from the polynomial expansions using a Gaussian kernel density estimator and employed to estimate the probability of conflict. The arbitrary polynomial chaos technique allows the effects of uncertainties in complex nonlinear dynamical system, such as those underlying aircraft trajectory planners, to be quantified with high computational efficiency, only requiring the existence of a finite number of statistical moments of the random variables of the Karhunen-Lo`eve expansion, while avoiding any assumption on their probability distributions. In order to demonstrate the effectiveness of the proposed conflict detection method, numerical experiments are conducted through an optimal control based aircraft trajectory planner for a given wind forecast represented by an ensemble prediction system.
- Published
- 2024
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15. A Stochastic Switched Optimal Control Approach to Formation Mission Design for Commercial Aircraft
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Cerezo-Magaña, María, Olivares, Alberto, and Staffetti, Ernesto
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Mathematics - Optimization and Control - Abstract
This paper studies the formation mission design problem for commercial aircraft in the presence of uncertainties. Specifically, it considers uncertainties in the departure times of the aircraft and in the fuel burn savings for the trailing aircraft. Given several commercial flights, the problem consists in arranging them in formation or solo flights and finding the trajectories that minimize the expected value of the direct operating cost of the flights. The formation mission design problem is formulated as an optimal control problem of a stochastic switched dynamical system and solved using nonintrusive generalized polynomial chaos based stochastic collocation. The stochastic collocation method converts the stochastic switched optimal control problem into an augmented deterministic switched optimal control problem. With this approach, a small number of sample points of the random parameters are used to jointly solve particular instances of the switched optimal control problem. The obtained solutions are then expressed as orthogonal polynomial expansions in terms of the random parameters using these sample points. This technique allows statistical and global sensitivity analysis of the stochastic solutions to be conducted at a low computational cost. The aim of this study is to establish if, in the presence of uncertainties, a formation mission is beneficial with respect to solo flight in terms of the expected value of the direct operating costs. Several numerical experiments have been conducted in which uncertainties on the departure times and on the fuel saving during formation flight have been considered. The obtained results demonstrate that benefits can be achieved even in the presence of these uncertainties.
- Published
- 2024
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16. Formation Mission Design for Commercial Aircraft Using Switched Optimal Control Techniques
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Cerezo-Magaña, María, Olivares, Alberto, and Staffetti, Ernesto
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Mathematics - Optimization and Control - Abstract
In this article, the formation mission design problem for commercial aircraft is studied. Given the departure times and the departure and arrival locations of several commercial flights, the relevant weather forecast, and the expected fuel savings during formation flight, the problem consists in establishing how to organize them in formation or solo flights and in finding the trajectories that minimize the overall direct operating cost of the flights. Each aircraft can fly solo or in different positions inside a formation. Therefore, the mission is modeled as a switched dynamical system, in which the discrete state describes the combination of flight modes of the individual aircraft and logical constraints in disjunctive form establish the switching logic among the discrete states of the system. The formation mission design problem has been formulated as an optimal control problem of a switched dynamical system and solved using an embedding approach, which allows switching decision among discrete states to be modeled without relying on binary variables. The resulting problem is a classical optimal control problem which has been solved using a knotting pseudospectral method. Several numerical experiments have been conducted to demonstrate the effectiveness of this approach. The obtained results show that formation flight has great potential to reduce fuel consumption and emissions.
- Published
- 2024
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17. Variables predictoras del rendimiento académico en el EEES: estilos de pensamiento, metas académicas, nota media de entrada a la titulación y horas de estudio
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Bernardo, Ana, Núñez, Carlos, Rodríguez, Celestino, Bernardo, Inmaculada, Fernández, Estrella, Cerezo, Rebeca, and González, Aroa
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Psychology: Cognitive Psychology ,Psychology: Social Psychology ,Cognitive Psychology ,Social Psychology - Abstract
El interés de este estudio se ha centrado en conocer el grado de adecuación de los estudiantes de primer curso universitario a las necesidades de aprendizaje que plantea el nuevo marco del Espacio Europeo de Educación Superior, en relación a los estilos de pensamiento, las metas académicas, la nota de entrada en la titulación y las horas de estudio. Para ello, se ha trabajado con una muestra de 559 alumnos/as universitarios de primer curso de 11 titulaciones pertenecientes a la Universidad de Oviedo, con un total de 190 hombres (34 %) y 369 mujeres (66 %). En esta investigación se han utilizado el Thinking Styles Questionnaire for Students (TSQS), el Cuestionario para la Evaluación de Metas Académicas-II (CEMA-II) y un cuestionario de datos personales y académicos. Los resultados de los análisis sugieren que los alumnos universitarios de primer año están orientados hacia metas de aprendizaje. Además, prefieren estilos de pensamiento relacionados con la resolución de las tareas de forma autónoma y creativa, independientemente de la titulación en la que estén matriculados.
- Published
- 2011
18. Variables predictoras del rendimiento académico en el EEES: estilos de pensamiento, metas académicas, nota media de entrada a la titulación y horas de estudio
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Bernardo, Dra. Ana, Núñez, Dr. Carlos, Rodríguez, Dr. Celestino, Bernardo, Dra. Inmaculada, Fernández, Dña. Estrella, Cerezo, Dra. Rebeca, and González, Dña. Aroa
- Subjects
Psychology: Cognitive Psychology ,Psychology: Social Psychology ,Cognitive Psychology ,Social Psychology - Abstract
El interés de este estudio se ha centrado en conocer el grado de adecuación de los estudiantes de primer curso universitario a las necesidades de aprendizaje que plantea el nuevo marco del Espacio Europeo de Educación Superior, en relación a los estilos de pensamiento, las metas académicas, la nota de entrada en la titulación y las horas de estudio. Para ello, se ha trabajado con una muestra de 559 alumnos/as universitarios de primer curso de 11 titulaciones pertenecientes a la Universidad de Oviedo, con un total de 190 hombres (34 %) y 369 mujeres (66 %). En esta investigación se han utilizado el Thinking Styles Questionnaire for Students (TSQS), el Cuestionario para la Evaluación de Metas Académicas-II (CEMA-II) y un cuestionario de datos personales y académicos. Los resultados de los análisis sugieren que los alumnos universitarios de primer año están orientados hacia metas de aprendizaje. Además, prefieren estilos de pensamiento relacionados con la resolución de las tareas de forma autónoma y creativa, independientemente de la titulación en la que estén matriculados.
- Published
- 2011
19. COVID-19 Stressors, Ethnic Discrimination, COVID-19 Fears, and Mental Health among Latinx College Students
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Delida Sanchez, Fiorella L. Carlos Chavez, Kevin M. Wagner, German A. Cadenas, Lucas Torres, and Alison Cerezo
- Abstract
This study examined the links between COVID-19 psychosocial stressors, ethnic discrimination, COVID-19 fears, and their combined effects on mental health outcomes among U.S.-based Latinx college students (N = 148; M[subscript age] = 20.68, SD = 2.53). Findings showed that sleep and eating disturbances, emotional distress, and work disruptions were linked with fear of contamination, fear of social distancing, and fear of pandemic impact. Further, ethnic discrimination was found to uniquely contribute to COVID-19 fears above and beyond COVID-19 psychosocial stressors. Finally, COVID-19 emotional distress and COVID fear of pandemic impact were significantly linked to anxiety and depression symptomatology. Recommendations for practice and future research are provided.
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- 2024
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20. Demographic And Clinical Characteristics Of Patients Prescribed Proprotein Convertase Subtilisin/kexin Type 9 Inhibitor Therapy And Patients Whose Current Lipid-Lowering Therapy Was Modified
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Baum SJ, Wade RL, Xiang P, Arellano J, Cerezo Olmos C, Nunna S, Chen CC, Carter CM, and Desai NR
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cardiovascular risk ,lipid-lowering therapy ,low-density lipoprotein ,pcsk9 inhibitor ,real-world treatment patterns ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Seth J Baum,1,2 Rolin L Wade,3 Pin Xiang,4 Jorge Arellano,4 Cesar Cerezo Olmos,5 Sasikiran Nunna,6 Chi-Chang Chen,6 Cathryn M Carter,7 Nihar R Desai8 1Department of Integrated Medical Sciences, Charles E Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA; 2Preventive Cardiology Inc, Boca Raton, FL, USA; 3Medical and Scientific Services, IQVIA, Plymouth Meeting, PA, USA; 4Global Health Economics, Amgen Inc, Thousand Oaks, CA, USA; 5US Medical, Amgen Inc, Thousand Oaks, CA, USA; 6Real-World Evidence Solutions, IQVIA, Plymouth Meeting, PA, USA; 7Global Publications, Amgen Inc, Thousand Oaks, CA, USA; 8Section of Cardiovascular Medicine, Center for Outcomes Research and Evaluation, Yale School of Medicine, New Haven, CT, USACorrespondence: Rolin L WadeIQVIA, One IMS Drive, Plymouth Meeting, PA 19462, USATel +1 215 434 812 2958Email Rolin.Wade@iqvia.comPurpose: Our objective was to describe the demographic and clinical characteristics of real-world patients in the US with elevated low-density lipoprotein cholesterol (LDL-C) whose lipid-lowering therapy (LLT) ─ both proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor and non-PCSK9 inhibitor ─ was actively modified.Methods: This retrospective cohort study used linked laboratory (Prognos), pharmacy (IMS Formulary Impact Analyzer), and medical claims (IQVIA Dx/LRx or PharMetrics Plus) data. PCSK9 inhibitor–prescribed patients with LDL-C ≥70 mg/dL (multiply by 0.02586 for mmol/L) at the time of prescription were matched by LDL-C test date to patients whose non-PCSK9 inhibitor therapy was modified by intensifying statin therapy, switching statins without intensification, or augmenting with ezetimibe (N=12,345 in each cohort). Baseline demographics, use of LLT, LDL-C values, atherosclerotic cardiovascular disease (ASCVD) diagnoses and cardiovascular comorbidities, and occurrence of major adverse cardiovascular events (MACE) were assessed during the 2-year pre-index period.Results: Mean age was 66.2 years in the PCSK9 inhibitor cohort and 64.1 years in the cohort whose LLT regimen was otherwise modified. Respectively, mean baseline LDL-C values were 150 and 121 mg/dL; 60.3% and 39.0% of patients had ASCVD diagnoses, and 9.6% and 5.1% had experienced a recent MACE. Prevalence of ASCVD diagnoses in the PCSK9 inhibitor and modified non-PCSK9 inhibitor cohorts, respectively, was 15.5% vs 9.1% for acute coronary syndrome, 20.7% vs 8.7% for coronary revascularization, and 22.2% vs 5.1% for possible familial hypercholesterolemia. In addition, 19.8% of patients in the PCSK9 inhibitor cohort were receiving both statins and ezetimibe vs 5.0% in the modified LLT cohort.Conclusion: Physicians are prescribing PCSK9 inhibitor therapy to patients with markedly elevated LDL-C levels who also have comorbid risk factors for adverse cardiovascular events. These results may be of interest to payers and policymakers involved in devising access strategies for PCSK9 inhibitors.Keywords: cardiovascular risk, lipid-lowering therapy, low-density lipoprotein, PCSK9 inhibitor, real-world treatment patterns
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- 2019
21. Montmorillonite-norfloxacin nanocomposite intended for healing of infected wounds
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García-Villén F, Faccendini A, Aguzzi C, Cerezo P, Bonferoni MC, Rossi S, Grisoli P, Ruggeri M, Ferrari F, Sandri G, and Viseras C
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montmorillonite ,norfloxacin ,nanocomposite ,solid state characterization ,wound healing ,Medicine (General) ,R5-920 - Abstract
Fatima García-Villén,1 Angela Faccendini,2 Carola Aguzzi,1 Pilar Cerezo,1 Maria Cristina Bonferoni,2 Silvia Rossi,2 Pietro Grisoli,2 Marco Ruggeri,2 Franca Ferrari,2 Giuseppina Sandri,2 Cesar Viseras11Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, Campus of Cartuja, Granada, Spain; 2Department of Drug Sciences, Faculty of Pharmacy, University of Pavia, Pavia 27100, ItalyBackground: Chronic cutaneous wounds represent a major issue in medical care and are often prone to infections.Purpose: The aim of this study was the design of a clay mineral-drug nanocomposite based on montmorillonite and norfloxacin (NF, antimicrobial drug) as a powder for cutaneous application, to enhance wound healing in infected skin lesions.Methods: The nanocomposite has been prepared by means of an intercalation solution procedure. Adsorption isotherm, solid-state characterization of the nanocomposite, drug loading capacity and its release have been performed. Moreover, cytocompatibility, in vitro fibroblast proliferation and antimicrobial activity against Pseudomonas aeruginosa and Staphylococcus aureus were assessed.Results: The clay drug adsorption isotherm demonstrates that the mechanism of NF intercalation into montmorillonite galleries is the adsorption as one single process, due to the charge–charge interaction between protonated NF and negatively charged montmorillonite edges in the interlayer space. Nanocomposite is biocompatible and it is characterized by antimicrobial activity greater than the free drug: this is due to its nanostructure and controlled drug release properties.Conclusion: Considering the results obtained, NF–montmorillonite nanocomposite seems a promising tool to treat infected skin lesions or skin wounds prone to infection, as chronic ulcers (diabetic foot, venous leg ulcers) and burns.Keywords: montmorillonite, norfloxacin, nanocomposite, solid state characterization, wound healing
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- 2019
22. Young foreign women in prison: A case study in Malaga prison
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Cerezo Anabel I. and Izco María
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prison ,discrimination ,women ,immigration ,age ,spain ,Criminal law and procedure ,K5000-5582 - Abstract
The aim of this paper is to present the results of the research on the reality that young migrant women face in prison, trying to analyze whether they, judging by their own speech, consider themselves victims of some sorts of discrimination in Malaga’s prison. The main objective is to get to know the previous history of women before entry to prison, their criminal experience, experience in the judicial process and their daily activities in the penitentiary centre, as well as the treatment received by the prison staff. In addition, the paper tries to explain the expectations for the future of these young women after their release. The final conclusions reflect a very complicated situation for women living in Malaga prison, especially when factors such as age and migration are also involved.
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- 2019
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23. Architectures and random properties of symplectic quantum circuits
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García-Martín, Diego, Braccia, Paolo, and Cerezo, M.
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Quantum Physics ,Computer Science - Machine Learning - Abstract
Parametrized and random unitary (or orthogonal) $n$-qubit circuits play a central role in quantum information. As such, one could naturally assume that circuits implementing symplectic transformation would attract similar attention. However, this is not the case, as $\mathbb{SP}(d/2)$ -- the group of $d\times d$ unitary symplectic matrices -- has thus far been overlooked. In this work, we aim at starting to right this wrong. We begin by presenting a universal set of generators $\mathcal{G}$ for the symplectic algebra $i\mathfrak{sp}(d/2)$, consisting of one- and two-qubit Pauli operators acting on neighboring sites in a one-dimensional lattice. Here, we uncover two critical differences between such set, and equivalent ones for unitary and orthogonal circuits. Namely, we find that the operators in $\mathcal{G}$ cannot generate arbitrary local symplectic unitaries and that they are not translationally invariant. We then review the Schur-Weyl duality between the symplectic group and the Brauer algebra, and use tools from Weingarten calculus to prove that Pauli measurements at the output of Haar random symplectic circuits can converge to Gaussian processes. As a by-product, such analysis provides us with concentration bounds for Pauli measurements in circuits that form $t$-designs over $\mathbb{SP}(d/2)$. To finish, we present tensor-network tools to analyze shallow random symplectic circuits, and we use these to numerically show that computational-basis measurements anti-concentrate at logarithmic depth., Comment: 13+7 pages, 8 figures
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- 2024
24. A Review of Barren Plateaus in Variational Quantum Computing
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Larocca, Martin, Thanasilp, Supanut, Wang, Samson, Sharma, Kunal, Biamonte, Jacob, Coles, Patrick J., Cincio, Lukasz, McClean, Jarrod R., Holmes, Zoë, and Cerezo, M.
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Quantum Physics ,Computer Science - Machine Learning ,Statistics - Machine Learning - Abstract
Variational quantum computing offers a flexible computational paradigm with applications in diverse areas. However, a key obstacle to realizing their potential is the Barren Plateau (BP) phenomenon. When a model exhibits a BP, its parameter optimization landscape becomes exponentially flat and featureless as the problem size increases. Importantly, all the moving pieces of an algorithm -- choices of ansatz, initial state, observable, loss function and hardware noise -- can lead to BPs when ill-suited. Due to the significant impact of BPs on trainability, researchers have dedicated considerable effort to develop theoretical and heuristic methods to understand and mitigate their effects. As a result, the study of BPs has become a thriving area of research, influencing and cross-fertilizing other fields such as quantum optimal control, tensor networks, and learning theory. This article provides a comprehensive review of the current understanding of the BP phenomenon., Comment: 21 pages, 10 boxes
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- 2024
25. Camera Motion Estimation from RGB-D-Inertial Scene Flow
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Cerezo, Samuel and Civera, Javier
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Computer Science - Computer Vision and Pattern Recognition - Abstract
In this paper, we introduce a novel formulation for camera motion estimation that integrates RGB-D images and inertial data through scene flow. Our goal is to accurately estimate the camera motion in a rigid 3D environment, along with the state of the inertial measurement unit (IMU). Our proposed method offers the flexibility to operate as a multi-frame optimization or to marginalize older data, thus effectively utilizing past measurements. To assess the performance of our method, we conducted evaluations using both synthetic data from the ICL-NUIM dataset and real data sequences from the OpenLORIS-Scene dataset. Our results show that the fusion of these two sensors enhances the accuracy of camera motion estimation when compared to using only visual data., Comment: Accepted to CVPR2024 Workshop on Visual Odometry and Computer Vision Applications
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- 2024
26. Implementation of complex-valued sliding mode controllers in three-phase power converters
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Dòria-Cerezo, Arnau, Boira, Pau, Repecho, Víctor, and Biel, Domingo
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Electrical Engineering and Systems Science - Systems and Control - Abstract
This paper presents two methods for implementing complex-valued sliding mode controllers in three-phase power converters. The paper includes the description of the algorithms and a detailed analysis of the proposed implementations. The methods, that are easy to code and have a low computational burden, retain the sliding mode properties of robustness and fast response and do not require any additional processing often used to decouple the dynamics of the three-phase system. The performance of the methods is compared in numerical simulations, and the algorithms are experimentally tested in a microcontroller using a Hardware-in-the-Loop platform.
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- 2024
27. Crystallographic dependence of Field Evaporation Energy Barrier in metals using Field Evaporation Energy Loss Spectroscopy mapping
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Vurpillot, François, Hatzoglou, Constantinos, Klaes, Benjamin, Rousseau, Loic, Maillet, Jean-Baptiste, Blum, Ivan, Gault, Baptiste, and Cerezo, Alfred
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Condensed Matter - Materials Science - Abstract
Atom probe tomography data is composed of a list of coordinates of the reconstructed atoms in the probed volume. The elemental identity of each atom is derived from time-of-flight mass spectrometry, with no local energetic or chemical information readily available within the mass spectrum. Here, we used a new data processing technique referred to as field evaporation energy loss spectroscopy (FEELS), which analyses the tails of mass peaks. FEELS was used to extract critical energetic parameters that characterize the field evaporation process, which are related to the binding energy of atoms to the surface under intense electrostatic field and dependent of the path followed by the departing atoms during the field evaporation process. We focused our study on different pure face centered cubic metals (Al, Ni, Rh). We demonstrate that the energetic parameters extracted from mass spectra can be mapped in 2D with nanometric resolution. A dependence on the considered crystallographic planes is observed, with sets of planes of low Miller indices showing a lower sensitivity to the intensity of the electric field, which indicates a lower effective attachment energy. The temperature is also an important parameter in particular for Al, which we attribute to an energetic transition between two paths of field evaporation between 25K and 60K close to (002) pole at the specimen's surface. This paper shows that the complex information that can be retrieved from the measured energy loss of surface atoms is important both instrumentally and fundamentally.
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- 2024
28. Symbolic and User-friendly Geometric Algebra Routines (SUGAR) for Computations in Matlab
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Velasco, Manel, Zaplana, Isiah, Dória-Cerezo, Arnau, and Martí, Pau
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Computer Science - Mathematical Software ,Computer Science - Robotics ,Electrical Engineering and Systems Science - Systems and Control ,G.4 - Abstract
Geometric algebra (GA) is a mathematical tool for geometric computing, providing a framework that allows a unified and compact approach to geometric relations which in other mathematical systems are typically described using different more complicated elements. This fact has led to an increasing adoption of GA in applied mathematics and engineering problems. However, the scarcity of symbolic implementations of GA and its inherent complexity, requiring a specific mathematical background, make it challenging and less intuitive for engineers to work with. This prevents wider adoption among more applied professionals. To address this challenge, this paper introduces SUGAR (Symbolic and User-friendly Geometric Algebra Routines), an open-source toolbox designed for Matlab and licensed under the MIT License. SUGAR facilitates the translation of GA concepts into Matlab and provides a collection of user-friendly functions tailored for GA computations, including support for symbolic operations. It supports both numeric and symbolic computations in high-dimensional GAs. Specifically tailored for applied mathematics and engineering applications, SUGAR has been meticulously engineered to represent geometric elements and transformations within two and three-dimensional projective and conformal geometric algebras, aligning with established computational methodologies in the literature. Furthermore, SUGAR efficiently handles functions of multivectors, such as exponential, logarithmic, sinusoidal, and cosine functions, enhancing its applicability across various engineering domains, including robotics, control systems, and power electronics. Finally, this work includes four distinct validation examples, demonstrating SUGAR's capabilities across the above-mentioned fields and its practical utility in addressing real-world applied mathematics and engineering problems., Comment: 33 pages, 6 figures, journal paper submitted to ACM TOMS
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- 2024
29. Free boundary CMC annuli in spherical and hyperbolic balls
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Cerezo, Alberto, Fernandez, Isabel, and Mira, Pablo
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Mathematics - Differential Geometry ,53A10, 53C42 - Abstract
We construct, for any $H\in \mathbb{R}$, infinitely many free boundary annuli in geodesic balls of $\mathbb{S}^3$ with constant mean curvature $H$ and a discrete, non-rotational, symmetry group. Some of these free boundary CMC annuli are actually embedded if $H\geq 1/\sqrt{3}$. We also construct embedded, non-rotational, free boundary CMC annuli in geodesic balls of $\mathbb{H}^3$, for all values $H>1$ of the mean curvature $H$., Comment: 42 pages, 7 figures
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- 2024
30. Computing exact moments of local random quantum circuits via tensor networks
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Braccia, Paolo, Bermejo, Pablo, Cincio, Lukasz, and Cerezo, M.
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Quantum Physics - Abstract
A basic primitive in quantum information is the computation of the moments $\mathbb{E}_U[{\rm Tr}[U\rho U^\dagger O]^t]$. These describe the distribution of expectation values obtained by sending a state $\rho$ through a random unitary $U$, sampled from some distribution, and measuring the observable $O$. While the exact calculation of these moments is generally hard, if $U$ is composed of local random gates, one can estimate $\mathbb{E}_U[{\rm Tr}[U\rho U^\dagger O]^t]$ by performing Monte Carlo simulations of a Markov chain-like process. However, this approach can require a prohibitively large number of samples, or suffer from the sign problem. In this work, we instead propose to estimate the moments via tensor networks, where the local gates moment operators are mapped to small dimensional tensors acting on their local commutant bases. By leveraging representation theoretical tools, we study the local tensor dimension and we provide bounds for the bond dimension of the matrix product states arising from deep circuits. We compare our techniques against Monte Carlo simulations, showing that we can significantly out-perform them. Then, we showcase how tensor networks can exactly compute the second moment when $U$ is a quantum neural network acting on thousands of qubits and having thousands of gates. To finish, we numerically study the anticoncentration phenomena of circuits with orthogonal random gates, a task which cannot be studied via Monte Carlo due to sign problems., Comment: 15 + 8 pages, 9 figures, updated to published version
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- 2024
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31. Combining systems and synthetic biology for in vivo enzymology
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Castaño-Cerezo, Sara, Chamas, Alexandre, Kulyk, Hanna, Treitz, Christian, Bellvert, Floriant, Tholey, Andreas, Galéote, Virginie, Camarasa, Carole, Heux, Stéphanie, Garcia-Alles, Luis F, Millard, Pierre, and Truan, Gilles
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- 2024
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32. Odour characterisation of recycled HDPE in different washing and processing processes
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Martínez, Juan López, Rodríguez Rego, Jesús Manuel, Cerezo, Laura Mendoza, Madrigal, María Dolores Samper, and Macías-García, Antonio
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- 2024
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33. External validation of the RIETE and SOME scores for occult cancer in patients with venous thromboembolism: a multicentre cohort study
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Franco-Moreno, Anabel, Morejón-Girón, José Bascuñana, Agudo-Blas, Paloma, de Ancos-Aracil, Cristina Lucía, Muñoz-Rivas, Nuria, Farfán-Sedano, Ana Isabel, Ruiz-Ruiz, Justo, Torres-Macho, Juan, Bustamante-Fermosel, Ana, Alfaro-Fernández, Nuria, Ruiz-Giardín, José Manuel, and Madroñal-Cerezo, Elena
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- 2024
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34. Barriers and Strategies to Optimize the Use of Glucagon-Like Peptide 1 Receptor Agonists in People with Type 2 Diabetes and High Cardiovascular Risk or Established Cardiovascular Disease: A Delphi Consensus in Spain
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Botana López, Manuel, Camafort Babkowski, Miguel, Campuzano Ruiz, Raquel, Cebrián Cuenca, Ana, Gargallo Fernández, Manuel, David de Paz, Héctor, Redondo-Antón, Jennifer, Artime, Esther, Díaz-Cerezo, Silvia, and Rubio de Santos, Miriam
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- 2024
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35. Poesía by Pedro de Espinosa (review)
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Cerezo, Rafael Bonilla
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- 2017
36. Obra selecta by, Anastasio Pantaleón de Ribera (review)
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Cerezo, Rafael Bonilla
- Published
- 2017
37. Segundo de Chomón y el arte de un cine "sin literatura"
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Cerezo, Alicia
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- 2017
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38. Effect of the economic crisis on the use of health and home care services among Spanish COPD patients
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de Miguel-Diez J, Lopez-de-Andres A, Hernandez-Barrera V, Jimenez-Trujillo I, Puente-Maestu L, Cerezo-Lajas A, and Jimenez-Garcia R
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COPD ,healthcare services ,population-based ,time trends ,survey ,economic crisis. ,Diseases of the respiratory system ,RC705-779 - Abstract
Javier de Miguel-Diez,1 Ana Lopez-de-Andres,2 Valentin Herandez-Barrera,2 Isabel Jimenez-Trujillo,2 Luis Puente-Maestu,1 Alicia Cerezo-Lajas,1 Rodrigo Jimenez-Garcia2 1Respiratory Department, Hospital General Universitario Gregorio Marañón, Facultad de Medicina, Universidad Complutense de Madrid (UCM), Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain; 2Preventive Medicine and Public Health Teaching and Research Unit, Health Sciences Faculty, Universidad Rey Juan Carlos, Alcorcón, Madrid, Spain Background: Chronic obstructive pulmonary disease (COPD) is a major cause of disability and death worldwide. Consequently, COPD patients are frequent users of health and social resources. Therefore, they are highly vulnerable to decreases in investment in healthcare services. We aimed to describe the utilization of health and home care services among Spanish COPD patients during the economic crisis to identify factors independently associated with changes in the utilization of these services and to study the time trends from 2009 to 2014.Methods: We used data from the European Health Interview Surveys for Spain (EHSS) conducted between 2009/2010 (n=22,188) and 2014 (n=22,842). We included responses from adults with COPD aged 40 years or over. Dependent variables included self-reported hospitalizations during the previous year, general practitioner (GP) visits during the last 4 weeks, other health care services used during the previous year (nursing, rehabilitation, and psychological services), and home care services use during the previous year. Independent variables included demographic and socioeconomic characteristics, health status variables, and lifestyles.Results: We identified 1,328 and 1,008 COPD patients from EHSS 2009 and EHSS 2014, respectively. We observed a significant increase in non-GP services use (30.6% in 2009 vs 39.11% in 2014; p
- Published
- 2018
39. A holographic mobile-based application for practicing pronunciation of basic English vocabulary for Spanish speaking children
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Cerezo, R., Calderon, V., and Romero, C.
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Computer Science - Human-Computer Interaction - Abstract
This paper describes a holographic mobile-based application designed to help Spanish-speaking children to practice the pronunciation of basic English vocabulary words. The mastery of vocabulary is a fundamental step when learning a language but is often perceived as boring. Producing the correct pronunciation is frequently regarded as the most difficult and complex skill for new learners of English. In order to address these problems this research takes advantage of the power of multi-channel stimuli (sound, image and interaction) in a mobilebased hologram application in order to motivate students and improve their experience of practicing. We adapted the prize-winning HolograFX game and developed a new mobile application to help practice English pronunciation. A 3D holographic robot that acts as a virtual teacher interacts via voice with the children. To test the tool we carried out an experiment with 70 Spanish pre-school children divided into three classes, the control group using traditional methods such as images in books and on the blackboard, and two experimental groups using our drills and practice software. One experimental group used the mobile application without the holographic game and the other experimental group used the application with the holographic game. We performed pre-test and post-test performance assessments, a satisfaction survey and emotion analysis. The results are very promising. They show that the use of the holographic mobile-based application had a significant impact on the children's motivation. It also improved their performance compared to traditional methods used in the classroom.
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- 2024
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40. Process mining for self-regulated learning assessment in e-learning
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Cerezo, R., Bogarin, A., Esteban, M., and Romero, C.
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Computer Science - Computers and Society ,Computer Science - Machine Learning - Abstract
Content assessment has broadly improved in e-learning scenarios in recent decades. However, the eLearning process can give rise to a spatial and temporal gap that poses interesting challenges for assessment of not only content, but also students' acquisition of core skills such as self-regulated learning. Our objective was to discover students' self-regulated learning processes during an eLearning course by using Process Mining Techniques. We applied a new algorithm in the educational domain called Inductive Miner over the interaction traces from 101 university students in a course given over one semester on the Moodle 2.0 platform. Data was extracted from the platform's event logs with 21629 traces in order to discover students' self-regulation models that contribute to improving the instructional process. The Inductive Miner algorithm discovered optimal models in terms of fitness for both Pass and Fail students in this dataset, as well as models at a certain level of granularity that can be interpreted in educational terms, which are the most important achievement in model discovery. We can conclude that although students who passed did not follow the instructors' suggestions exactly, they did follow the logic of a successful self-regulated learning process as opposed to their failing classmates. The Process Mining models also allow us to examine which specific actions the students performed, and it was particularly interesting to see a high presence of actions related to forum-supported collaborative learning in the Pass group and an absence of those in the Fail group.
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- 2024
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41. Improving prediction of students' performance in intelligent tutoring systems using attribute selection and ensembles of different multimodal data sources
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Chango, W., Cerezo, R., Sanchez-Santillan, M., Azevedo, R., and Romero, C.
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Computer Science - Computers and Society ,Computer Science - Artificial Intelligence ,Computer Science - Human-Computer Interaction ,Computer Science - Machine Learning - Abstract
The aim of this study was to predict university students' learning performance using different sources of data from an Intelligent Tutoring System. We collected and preprocessed data from 40 students from different multimodal sources: learning strategies from system logs, emotions from face recording videos, interaction zones from eye tracking, and test performance from final knowledge evaluation. Our objective was to test whether the prediction could be improved by using attribute selection and classification ensembles. We carried out three experiments by applying six classification algorithms to numerical and discretized preprocessed multimodal data. The results show that the best predictions were produced using ensembles and selecting the best attributes approach with numerical data.
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- 2024
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42. Multi-source and multimodal data fusion for predicting academic performance in blended learning university courses
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Chango, W., Cerezo, R., and Romero, C.
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Computer Science - Computers and Society ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning - Abstract
In this paper we applied data fusion approaches for predicting the final academic performance of university students using multiple-source, multimodal data from blended learning environments. We collected and preprocessed data about first-year university students from different sources: theory classes, practical sessions, on-line Moodle sessions, and a final exam. Our objective was to discover which data fusion approach produced the best results using our data. We carried out experiments by applying four different data fusion approaches and six classification algorithms. The results showed that the best predictions were produced using ensembles and selecting the best attributes approach with discretized data. The best prediction models showed us that the level of attention in theory classes, scores in Moodle quizzes, and the level of activity in Moodle forums were the best set of attributes for predicting students' final performance in our courses.
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- 2024
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43. Discovering Geo-dependent Stories by Combining Density-based Clustering and Thread-based Aggregation techniques
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Cerezo-Costas, Héctor, Vilas, Ana Fernández, Martín-Vicente, Manuela, and Díaz-Redondo, Rebeca P.
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Computer Science - Social and Information Networks ,Computer Science - Artificial Intelligence - Abstract
Citizens are actively interacting with their surroundings, especially through social media. Not only do shared posts give important information about what is happening (from the users' perspective), but also the metadata linked to these posts offer relevant data, such as the GPS-location in Location-based Social Networks (LBSNs). In this paper we introduce a global analysis of the geo-tagged posts in social media which supports (i) the detection of unexpected behavior in the city and (ii) the analysis of the posts to infer what is happening. The former is obtained by applying density-based clustering techniques, whereas the latter is consequence of applying natural language processing. We have applied our methodology to a dataset obtained from Instagram activity in New York City for seven months obtaining promising results. The developed algorithms require very low resources, being able to analyze millions of data-points in commodity hardware in less than one hour without applying complex parallelization techniques. Furthermore, the solution can be easily adapted to other geo-tagged data sources without extra effort., Comment: 11 pages, 12 figures, journal
- Published
- 2023
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44. Does provable absence of barren plateaus imply classical simulability? Or, why we need to rethink variational quantum computing
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Cerezo, M., Larocca, Martin, García-Martín, Diego, Diaz, N. L., Braccia, Paolo, Fontana, Enrico, Rudolph, Manuel S., Bermejo, Pablo, Ijaz, Aroosa, Thanasilp, Supanut, Anschuetz, Eric R., and Holmes, Zoë
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Quantum Physics ,Computer Science - Machine Learning ,Statistics - Machine Learning - Abstract
A large amount of effort has recently been put into understanding the barren plateau phenomenon. In this perspective article, we face the increasingly loud elephant in the room and ask a question that has been hinted at by many but not explicitly addressed: Can the structure that allows one to avoid barren plateaus also be leveraged to efficiently simulate the loss classically? We present strong evidence that commonly used models with provable absence of barren plateaus are also classically simulable, provided that one can collect some classical data from quantum devices during an initial data acquisition phase. This follows from the observation that barren plateaus result from a curse of dimensionality, and that current approaches for solving them end up encoding the problem into some small, classically simulable, subspaces. Thus, while stressing quantum computers can be essential for collecting data, our analysis sheds serious doubt on the non-classicality of the information processing capabilities of parametrized quantum circuits for barren plateau-free landscapes. We end by discussing caveats in our arguments, the role of smart initializations and the possibility of provably superpolynomial, or simply practical, advantages from running parametrized quantum circuits., Comment: 14+15 pages, 5 figures, 2 tables, minor corrections added
- Published
- 2023
45. INRISCO: INcident monitoRing In Smart COmmunities
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Igartua, Mónica Aguilar, Almenares, Florina, Redondo, Rebeca P. Díaz, Martín, Manuela I., Forné, Jordi, Campo, Celeste, Fernández, Ana, de la Cruz, Luis J., García-Rubio, Carlos, Marínn, Andrés, Mezher, Ahmad Mohamad, Díaz, Daniel, Cerezo, Héctor, Rebollo-Monedero, David, Arias, Patricia, and Rico, Francisco
- Subjects
Computer Science - Networking and Internet Architecture - Abstract
Major advances in information and communication technologies (ICTs) make citizens to be considered as sensors in motion. Carrying their mobile devices, moving in their connected vehicles or actively participating in social networks, citizens provide a wealth of information that, after properly processing, can support numerous applications for the benefit of the community. In the context of smart communities, the INRISCO proposal intends for (i) the early detection of abnormal situations in cities (i.e., incidents), (ii) the analysis of whether, according to their impact, those incidents are really adverse for the community; and (iii) the automatic actuation by dissemination of appropriate information to citizens and authorities. Thus, INRISCO will identify and report on incidents in traffic (jam, accident) or public infrastructure (e.g., works, street cut), the occurrence of specific events that affect other citizens life (e.g., demonstrations, concerts), or environmental problems (e.g., pollution, bad weather). It is of particular interest to this proposal the identification of incidents with a social and economic impact, which affects the quality of life of citizens.
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- 2023
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46. Symmetric derivatives of parametrized quantum circuits
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Wierichs, David, East, Richard D. P., Larocca, Martín, Cerezo, M., and Killoran, Nathan
- Subjects
Quantum Physics - Abstract
Symmetries are crucial for tailoring parametrized quantum circuits to applications, due to their capability to capture the essence of physical systems. In this work, we shift the focus away from incorporating symmetries in the circuit design and towards symmetry-aware training of variational quantum algorithms. For this, we introduce the concept of projected derivatives of parametrized quantum circuits, in particular the equivariant and covariant derivatives. We show that the covariant derivative gives rise to the quantum Fisher information and quantum natural gradient. This provides an operational meaning for the covariant derivative, and allows us to extend the quantum natural gradient to all continuous symmetry groups. Connecting to traditional particle physics, we confirm that our covariant derivative is the same as the one introduced in physical gauge theory. This work provides tools for tailoring variational quantum algorithms to symmetries by incorporating them locally in derivatives, rather than into the design of the circuit., Comment: 22+20 pages, 6+1 figures
- Published
- 2023
47. Introducing Modelling, Analysis and Control of Three-Phase Electrical Systems Using Geometric Algebra
- Author
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Velasco, Manel, Zaplana, Isiah, Dòria-Cerezo, Arnau, Duarte, Josué, and Martí, Pau
- Subjects
Electrical Engineering and Systems Science - Systems and Control - Abstract
State-of-the-art techniques for modeling, analysis and control of three-phase electrical systems belong to the real-valued multi-input/multi-output (MIMO) domain, or to the complex-valued nonlinear single-input/single-output (SISO) domain. In order to complement both domains while simplifying complexity and offering new analysis and design perspectives, this paper introduces the application of geometric algebra (GA) principles to the modeling, analysis and control of three-phase electrical systems. The key contribution for the modeling part is the identification of the transformation that allows transferring real-valued linear MIMO systems into GA-valued linear SISO representations (with independence of having a balanced or unbalanced system). Closed-loop stability analysis in the new space is addressed by using intrinsic properties of GA. In addition, a recipe for designing stabilizing and decoupling GA-valued controllers is provided. Numerical examples illustrate key developments and experiments corroborate the main findings.
- Published
- 2023
48. TIPO DE CAMBIO REAL, INNOVACIÓN Y CRECIMIENTO ECONÓMICO : UN ANÁLISIS COMPARATIVO PARA AMÉRICA LATINA Y ASIA
- Author
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Díaz, Heri Oscar Landa and García, Verónica Cerezo
- Published
- 2024
49. Practical consensus for the treatment and follow-up of primary aldosteronism: a multidisciplinary consensus document
- Author
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Araujo-Castro, Marta, Ruiz-Sánchez, Jorge Gabriel, Ramírez, Paola Parra, Martín Rojas-Marcos, Patricia, Aguilera-Saborido, Almudena, Gómez Cerezo, Jorge Francisco, López Lazareno, Nieves, Torregrosa, María Eugenia, Gorrín Ramos, Jorge, Oriola, Josep, Poch, Esteban, Oliveras, Anna, Méndez Monter, José Vicente, Gómez Muriel, Isabel, Bella-Cueto, María Rosa, Mercader Cidoncha, Enrique, Runkle, Isabelle, and Hanzu, Felicia A.
- Published
- 2024
- Full Text
- View/download PDF
50. Screening and diagnosis of primary aldosteronism. Consensus document of all the Spanish Societies involved in the management of primary aldosteronism
- Author
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Araujo-Castro, Marta, Ruiz-Sánchez, Jorge Gabriel, Parra Ramírez, Paola, Martín Rojas-Marcos, Patricia, Aguilera-Saborido, Almudena, Gómez Cerezo, Jorge Francisco, López Lazareno, Nieves, Torregrosa Quesada, María Eugenia, Gorrin Ramos, Jorge, Oriola, Josep, Poch, Esteban, Oliveras, Anna, Méndez Monter, José Vicente, Gómez Muriel, Isabel, Bella-Cueto, María Rosa, Mercader Cidoncha, Enrique, Runkle, Isabelle, and Hanzu, Felicia A.
- Published
- 2024
- Full Text
- View/download PDF
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