7 results on '"CERAD-Plus"'
Search Results
2. Fewer neurocognitive deficits and less brain atrophy by third ventricle measurement in PLWH treated with modern ART: A prospective analysis.
- Author
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Kaddu-Mulindwa, Dominic, Heit, Matthias, Wagenpfeil, Gudrun, Bewarder, Moritz, Fassbender, Klaus, Behnke, Stefanie, Yilmaz, Umut, and Fousse, Mathias
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CEREBRAL atrophy ,MODERN art ,ALZHEIMER'S disease ,NEUROBEHAVIORAL disorders ,HIV ,TRAIL Making Test ,PROSPECTIVE memory - Abstract
Background: Despite antiretroviral therapy, cognitive dysfunction seems to remain a major issue for people living with human immunodeficiency virus (PLWH). Previous studies showed a correlation between the width of the third ventricle (WTV) and neurocognitive disorders in PLWH. Patients and methods: We investigated prevalence and correlation of neuropsychological disorders using WTV as a brain atrophy marker examined by transcranial sonography and MRI in PLWH and healthy age- and gender-matched controls. We used Becks Depression Inventory (BDI) for depression screening, the questionnaires Fatigue Severity Scale (FSS) for fatigue and Short-Form-36 (SF36) for quality of life (QoL) evaluation and Consortium to establish a registry for Alzheimer's disease (CERAD-PLUS) as neuropsychological test battery. Results: 52 PLWH (47 males) and 28 non-infected controls (23 males) with a median age of 52 years (24-78 years) and 51 years (22-79) were analyzed. WTV correlated significantly with age (p < 0.01) but showed no significantly dierence in PLWH (median = 3.4mm) compared to healthy controls (median = 2.8mm) (p = 0.085). PLWH had both significantly higher BDI-Scores (p = 0.005) and FSS-Scores (p = 0.012). Controls reported higher QoL (SF-36) with significant dierences in most items. However, the overall cognitive performance (CERAD total score) showed no significant dierence. TheWTV of all subjects correlated with neurocognitive performancemeasured as CERAD total score (p = 0.009) and trail making tests A (p < 0.001) and B (p = 0.018). There was no correlation between the scores of BDI, FSS, SF-36, and CERAD-PLUS items and WTV. Conclusion: WTV is considered as a predictor of cognitive deficits in neurodegenerative diseases. Nevertheless, we found no significant dierence in WTV or overall cognitive performance between PLWH and controls. PLWH suer more often from depression and fatigue and report reduced QoL when compared to healthy controls. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
3. Fewer neurocognitive deficits and less brain atrophy by third ventricle measurement in PLWH treated with modern ART: A prospective analysis
- Author
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Dominic Kaddu-Mulindwa, Matthias Heit, Gudrun Wagenpfeil, Moritz Bewarder, Klaus Fassbender, Stefanie Behnke, Umut Yilmaz, and Mathias Fousse
- Subjects
HIV ,third ventricle diameter ,transcranial ultrasound ,HIV associated neurocognitive disorders ,fractional anisotropy ,CERAD-PLUS ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
BackgroundDespite antiretroviral therapy, cognitive dysfunction seems to remain a major issue for people living with human immunodeficiency virus (PLWH). Previous studies showed a correlation between the width of the third ventricle (WTV) and neurocognitive disorders in PLWH.Patients and methodsWe investigated prevalence and correlation of neuropsychological disorders using WTV as a brain atrophy marker examined by transcranial sonography and MRI in PLWH and healthy age- and gender-matched controls. We used Becks Depression Inventory (BDI) for depression screening, the questionnaires Fatigue Severity Scale (FSS) for fatigue and Short-Form-36 (SF36) for quality of life (QoL) evaluation and Consortium to establish a registry for Alzheimer's disease (CERAD-PLUS) as neuropsychological test battery.Results52 PLWH (47 males) and 28 non-infected controls (23 males) with a median age of 52 years (24–78 years) and 51 years (22–79) were analyzed. WTV correlated significantly with age (p < 0.01) but showed no significantly difference in PLWH (median = 3.4 mm) compared to healthy controls (median = 2.8 mm) (p = 0.085). PLWH had both significantly higher BDI-Scores (p = 0.005) and FSS-Scores (p = 0.012). Controls reported higher QoL (SF-36) with significant differences in most items. However, the overall cognitive performance (CERAD total score) showed no significant difference. The WTV of all subjects correlated with neurocognitive performance measured as CERAD total score (p = 0.009) and trail making tests A (p < 0.001) and B (p = 0.018). There was no correlation between the scores of BDI, FSS, SF-36, and CERAD-PLUS items and WTV.ConclusionWTV is considered as a predictor of cognitive deficits in neurodegenerative diseases. Nevertheless, we found no significant difference in WTV or overall cognitive performance between PLWH and controls. PLWH suffer more often from depression and fatigue and report reduced QoL when compared to healthy controls.
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- 2022
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4. Association of Cerebrospinal Fluid S100B Protein with Core Biomarkers and Cognitive Deficits in Prodromal and Mild Alzheimer's Disease.
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Christl, Julia, Verhülsdonk, Sandra, Pessanha, Francesca, Menge, Til, Seitz, Rüdiger J., Kujovic, Milenko, Höft, Barbara, Supprian, Tillmann, and Lange-Asschenfeldt, Christian
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ALZHEIMER'S disease , *CEREBROSPINAL fluid , *BIOMARKERS , *BIOLOGICAL tags , *MILD cognitive impairment , *NEUROPSYCHOLOGICAL tests - Abstract
Background: Increased expression of the astroglial Ca2+-binding protein S100B has been observed in various neurodegenerative diseases and also seems to play a role in the unfolding of pathophysiological events at early stages of Alzheimer's disease (AD).Objective: To examine the association of cerebrospinal fluid (CSF) levels of S100B with 1) established CSF core biomarkers total tau (tau), hyperphosphorylated tau (p-tau), and amyloid β1-42 (Aβ1-42) as well as neuron-specific enolase (NSE) CSF levels and 2) cognition in early AD and mild cognitive impairment (MCI) due to AD (MCI-AD).Methods: Retrospective study assessing 49 pooled charts of Memory Clinic and inpatients diagnosed with AD (N = 26) and MCI-AD (N = 23) according to the National Institute of Aging and Alzheimer's Disease Association (NIA-AA) criteria. Neuropsychological testing was performed with the Consortium to Establish a Registry for AD (CERAD)-Plus battery.Results: CSF levels of S100B correlated with NSE, but not the other CSF parameters. Stepwise multiple linear regression, adjusted for age, sex, and educational level, revealed that only increased CSF S100B was independently associated with lower CERAD-Plus total and Mini-Mental Status Examination scores together with poorer performance in wordlist learning (delayed recall and overall performance). We found no independent associations with other CSF biomarkers or cognitive domains.Conclusion: Our data suggest that CSF S100B may have a diagnostic value particularly at early stages of AD reflecting the significance of neuroinflammatory/astroglial processes. Thus, CSF S100B may complement the established array of available AD biomarkers to improve early stage diagnosis. [ABSTRACT FROM AUTHOR]- Published
- 2019
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5. Peripheral markers of Alzheimer's disease: Surveillance of white blood cells.
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Shad, Kaneez Fatima, Aghazadeh, Yashar, Ahmad, Sagheer, and Kress, Bodo
- Abstract
ABSTRACT Inflammation is part of the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. This is a mechanism of innate immunity, which may cause an increase in the number of monocytes and neutrophils circulating in the blood. Literature indicated that chronic inflammation might be a factor in developing neurological problems, including Alzheimer's, Parkinson's and other similar illnesses. Our main objective is to identify peripheral markers of Alzheimer's disease and for that purpose; we are looking at the profile of white blood cells focusing on monocytes, neutrophils, lymphocytes and basophils. Twenty-seven patients of Alzheimer's disease (AD), diagnosed by magnetic resonance imaging and neuropsychological tests were observed for their blood profile. Key observations during this study were that the levels of monocytes in the blood of the diagnosed AD patients were high irrespective of their age and sex. For those patients whose monocytes were in normal range their neutrophil levels were significantly high. Whereas blood levels of lymphocytes and basophils were found to be constantly low. Escalated levels of monocytes and neutrophils are hallmarks of chronic inflammation and may be precursor to Alzheimer's disease. A low lymphocyte count specifies that the body's resistance to fight infection is substantially reduced, whereas low basophil levels indicates their over utilization due to chronic allergic inflammatory condition. Future studies involved closer look at the cytokines produced by these white blood cells especially TNF IL-1, and IL-12, which are products of monocytes. Likewise, blood glucose and creatinine levels were high whereas calcium ions were low. Our studies indicated that white blood cells along with other inflammatory byproducts may act as peripheral markers for early diagnosis of Alzheimer's disease. Synapse 67:541-543, 2013. © 2013 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]
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- 2013
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6. Careful neuropsychological testing reveals a novel genetic marker, GSTO1*C, linked to the pre-stage of Alzheimer's disease
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Ellen Umlauf, Maria Zellner, Bettina Schiller, Michael Rainer, Petra Fuchs, Brigitte Wolf, and Eduard Rappold
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0301 basic medicine ,Gerontology ,Genetic Markers ,Male ,well-defined control group ,medicine.medical_specialty ,Genotype ,Apolipoprotein E4 ,Mutation, Missense ,Disease ,Neuropsychological Tests ,Logistic regression ,MMSE ,03 medical and health sciences ,0302 clinical medicine ,Research Paper: Gerotarget (Focus on Aging) ,Alzheimer Disease ,Internal medicine ,medicine ,Humans ,CERAD-Plus ,Cognitive Dysfunction ,Genetic Predisposition to Disease ,Alleles ,Aged ,Glutathione Transferase ,Aged, 80 and over ,Mini–Mental State Examination ,medicine.diagnostic_test ,business.industry ,Gerotarget ,Case-control study ,Genetic Variation ,Alzheimer's disease ,medicine.disease ,Mental Status and Dementia Tests ,Twin study ,MCI ,3. Good health ,Genetic load ,030104 developmental biology ,Oncology ,Genetic marker ,Case-Control Studies ,Regression Analysis ,Female ,business ,030217 neurology & neurosurgery - Abstract
// Ellen Umlauf 1 , Eduard Rappold 1 , Bettina Schiller 1 , Petra Fuchs 2 , Michael Rainer 3 , Brigitte Wolf 4 and Maria Zellner 1 1 Medical University of Vienna, Center of Physiology and Pharmacology, Institute of Physiology, Vienna, Austria 2 SMZ Otto Wagner Spital, 3rd Department of Psychiatry, Vienna, Austria 3 SMZ Ost, Karl Landsteiner Institut fur Gedachtnis- und Alzheimerforschung, Vienna, Austria 4 Medical University of Vienna, Surgery Research Laboratory, Department of Surgery, Vienna, Austria Correspondence to: Maria Zellner, email: // Keywords : Alzheimer’s disease, MCI, CERAD-Plus, MMSE, well-defined control group, Gerotarget Received : November 19, 2015 Accepted : May 25, 2016 Published : June 01, 2016 Abstract Approximately 30 million people currently suffer from late-onset Alzheimer’s disease (LOAD) worldwide. Twin studies demonstrated that 60 to 80% of LOAD is genetically determined, 20% of which remaining unassigned. This case-control study included 118 cognitively healthy controls, 52 patients with mild cognitive impairment (MCI; the pre-stage of LOAD) and 71 LOAD patients. The participants were genotyped for the genetic LOAD marker apolipoprotein E4 ( APOE4 ) and the single-nucleotide polymorphism rs4925 in glutathione S-transferase omega-1 ( GSTO1 ). Additive logistic regression showed a novel, statistically significant association of the major allele GSTO1*C with MCI (OR1.9; p = 0.032). However, identification of significant SNP-disease relations required well-defined study groups. When classifying participants solely by the short Mini Mental State examination (MMSE), the associations of GSTO1*C and the reference marker APOE4 with MCI were cancelled. Moreover, even identifying only the control group by MMSE nullified a statistically significant association (OR1.8; p = 0.045) between GSTO1*C and LOAD. In contrast, these statistical relations were retained when the detailed Consortium to Establish a Registry for Alzheimer’s Disease (CERAD-Plus) test battery was used. Hence, besides proposing rs4925 as a genetic marker for cognitive impairment, this work also emphasized the importance of carefully characterized controls in addition to well-diagnosed patients in case-control studies.
- Published
- 2015
7. Careful neuropsychological testing reveals a novel genetic marker, GSTO1*C, linked to the pre-stage of Alzheimer's disease.
- Author
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Umlauf E, Rappold E, Schiller B, Fuchs P, Rainer M, Wolf B, and Zellner M
- Subjects
- Aged, Aged, 80 and over, Alleles, Apolipoprotein E4 genetics, Case-Control Studies, Cognitive Dysfunction, Female, Genetic Markers, Genetic Predisposition to Disease, Genetic Variation, Genotype, Humans, Male, Mental Status and Dementia Tests, Mutation, Missense, Regression Analysis, Alzheimer Disease diagnosis, Alzheimer Disease genetics, Glutathione Transferase genetics, Neuropsychological Tests
- Abstract
Approximately 30 million people currently suffer from late-onset Alzheimer's disease (LOAD) worldwide. Twin studies demonstrated that 60 to 80% of LOAD is genetically determined, 20% of which remaining unassigned. This case-control study included 118 cognitively healthy controls, 52 patients with mild cognitive impairment (MCI; the pre-stage of LOAD) and 71 LOAD patients. The participants were genotyped for the genetic LOAD marker apolipoprotein E4 (APOE4) and the single-nucleotide polymorphism rs4925 in glutathione S-transferase omega-1 (GSTO1). Additive logistic regression showed a novel, statistically significant association of the major allele GSTO1*C with MCI (OR1.9; p = 0.032). However, identification of significant SNP-disease relations required well-defined study groups. When classifying participants solely by the short Mini Mental State examination (MMSE), the associations of GSTO1*C and the reference marker APOE4 with MCI were cancelled. Moreover, even identifying only the control group by MMSE nullified a statistically significant association (OR1.8; p = 0.045) between GSTO1*C and LOAD. In contrast, these statistical relations were retained when the detailed Consortium to Establish a Registry for Alzheimer's Disease (CERAD-Plus) test battery was used. Hence, besides proposing rs4925 as a genetic marker for cognitive impairment, this work also emphasized the importance of carefully characterized controls in addition to well-diagnosed patients in case-control studies., Competing Interests: The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. All authors declare no conflict of interest and concur with this submission.
- Published
- 2016
- Full Text
- View/download PDF
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