1. BMI1 in the heart: Novel functions beyond tumorigenesis
- Author
-
Han-Qing Liu, Di Fan, Zheng Yang, Qi-Zhu Tang, and Dan Yang
- Subjects
0301 basic medicine ,Regulator ,lcsh:Medicine ,CDKN2b, cyclin dependent kinase inhibitor 2b ,MSC, mesenchymal stem cell ,Review ,medicine.disease_cause ,HF, heart failure ,BMI1, B cell-specific Moloney murine leukemia virus integration site 1 ,Cardiac stem cell ,PRC1, polycomb repressive complex 1 ,0302 clinical medicine ,EPC, endothelial progenitor cell ,FACS, fluorescence-activated cell sorting ,Neoplasms ,Drug Discovery ,Medicine ,CM, cardiomyocyte ,Molecular Targeted Therapy ,Polycomb Repressive Complex 1 ,lcsh:R5-920 ,Signaling pathway ,Stem Cells ,General Medicine ,Shh, Sonic hedgehog ,TERT, telomerase reverse transcriptase ,Cell Transformation, Neoplastic ,Cardiovascular Diseases ,Organ Specificity ,030220 oncology & carcinogenesis ,Therapeutic strategies ,Cited 2, CBP/p300 interacting transactivator with ED-rich tail 2 ,iNOS, inducible nitric oxide synthase ,MI, myocardial infarction ,MMP-2, matrix metalloproteinase-2 ,PHLPP, PH domain and leucine‐rich repeat protein phosphatase ,Disease Susceptibility ,PRC1 ,Stem cell ,lcsh:Medicine (General) ,Signal Transduction ,macromolecular substances ,General Biochemistry, Genetics and Molecular Biology ,DDR, DNA damage response ,hUCB-MSC, human umbilical cord blood-derived MSC ,03 medical and health sciences ,ROS, reactive oxygen species ,Animals ,Humans ,PHLPP ,business.industry ,Myocardium ,lcsh:R ,Mesenchymal stem cell ,RB, Retinoblastoma ,medicine.disease ,BMI1 ,CICs, cancer-initialing cells ,030104 developmental biology ,iCM, induced cardiomyocyte ,Gene Expression Regulation ,Heart failure ,hMSC, human mesenchymal stem cell ,business ,Carcinogenesis ,DDM, Duchenne muscular dystrophy ,Neuroscience ,Biomarkers - Abstract
The BMI1 protein, a member of the PRC1 family, is a well recognised transcriptional suppressor and has the capability of maintaining the self-renewal and proliferation of tissue-specific stem cells. Numerous studies have established that BMI1 is highly expressed in a variety of malignant cancers and serves as a key regulator in the tumorigenesis process. However, our understanding of BMI1 in terminally differentiated organs, such as the heart, is relatively nascent. Importantly, emerging data support that, beyond the tumor, BMI1 is also expressed in the heart tissue and indeed exerts profound effects in various cardiac pathological conditions. This review gives a summary of the novel functions of BMI1 in the heart, including BMI1-positive cardiac stem cells and BMI1-mediated signaling pathways, which are involved in the response to various cardiac pathological stimuli. Besides, we summarize the recent progress of BMI1 in some novel and rapidly developing cardiovascular therapies. Furtherly, we highlight the properties of BMI1, a therapeutic target proved effective in cancer treatment, as a promising target to alleviate cardiovascular diseases.
- Published
- 2021