Search

Your search keyword '"CARITRO"' showing total 7 results
Start Over Author "CARITRO"
7 results on '"CARITRO"'

1. A new genomic tool for walnut (Juglans regia L.): development and validation of the high-density Axiom™ J. regia 700K SNP genotyping array

Author

California Walnut Commission, Fondazione Caritro, Martínez-García, Pedro J. [0000-0002-7647-5235], Marrano, Annarita, Martínez-García, Pedro J., Bianco, Luca, Sideli, Gina M., Di Pierro, Erica A., Leslie, Charles A., Stevens, Kristian A., Crepeau, Marc W., Troggio, Michela, Langley, Charles H., Neale, David B., California Walnut Commission, Fondazione Caritro, Martínez-García, Pedro J. [0000-0002-7647-5235], Marrano, Annarita, Martínez-García, Pedro J., Bianco, Luca, Sideli, Gina M., Di Pierro, Erica A., Leslie, Charles A., Stevens, Kristian A., Crepeau, Marc W., Troggio, Michela, Langley, Charles H., and Neale, David B.

Abstract

Over the last 20 years, global production of Persian walnut (Juglans regia L.) has grown enormously, likely reflecting increased consumption due to its numerous benefits to human health. However, advances in genome-wide association (GWA) studies and genomic selection (GS) for agronomically important traits in walnut remain limited due to the lack of powerful genomic tools. Here, we present the development and validation of a high-density 700K single nucleotide polymorphism (SNP) array in Persian walnut. Over 609K high-quality SNPs have been thoroughly selected from a set of 9.6 m genome-wide variants, previously identified from the high-depth re-sequencing of 27 founders of the Walnut Improvement Program (WIP) of University of California, Davis. To validate the effectiveness of the array, we genotyped a collection of 1284 walnut trees, including 1167 progeny of 48 WIP families and 26 walnut cultivars. More than half of the SNPs (55.7%) fell in the highest quality class of ‘Poly High Resolution’ (PHR) polymorphisms, which were used to assess the WIP pedigree integrity. We identified 151 new parent-offspring relationships, all confirmed with the Mendelian inheritance test. In addition, we explored the genetic variability among cultivars of different origin, revealing how the varieties from Europe and California were differentiated from Asian accessions. Both the reconstruction of the WIP pedigree and population structure analysis confirmed the effectiveness of the Applied Biosystems™ Axiom™ J. regia 700K SNP array, which initiates a novel genomic and advanced phase in walnut genetics and breeding.

Published
2019

2. Mother-to-Infant Microbial Transmission from Different Body Sites Shapes the Developing Infant Gut Microbiome

Author

European Commission, LEO Pharma Foundation, Fondazione Caritro, Ferretti, Pamela, Pasolli, Edoardo, Tett, Adrian, Asnicar, Francesco, Gorfer, Valentina, Fedi, Sabina, Armanini, Federica, Truong, Duy Tin, Manara, Serena, Zolfo, Moreno, Beghini, Francesco, Bertorelli, Roberto, de Sanctis, Veronica, Bariletti, Ilaria, Canto, Rosarita, Clementi,Rosanna, Cologna,Marina, Crifò, Tiziana, Cusumano, Giuseppina, Gottardi, Stefania, Innamorati, Claudia, Masè,Caterina, Postai,Daniela, Savoi, Daniela, Duranti, Sabrina, Lugli, Gabriele Andrea, Mancabelli, Leonardo, Turroni, Francesca, Ferrario, Chiara, Milani, Christian, Mangifesta, Marta, Anzalone, Rosaria, Viappiani, Alice, Yassour, Moran, Vlamakis, Hera, Xavier, Ramnik, Collado, María Carmen, Koren,Omry, Tateo, Saverio, Soffiati,Massimo, Pedrotti, Anna, Ventura, Marco, Huttenhower, Curtis, Bork, Peer, Segata, Nicola, European Commission, LEO Pharma Foundation, Fondazione Caritro, Ferretti, Pamela, Pasolli, Edoardo, Tett, Adrian, Asnicar, Francesco, Gorfer, Valentina, Fedi, Sabina, Armanini, Federica, Truong, Duy Tin, Manara, Serena, Zolfo, Moreno, Beghini, Francesco, Bertorelli, Roberto, de Sanctis, Veronica, Bariletti, Ilaria, Canto, Rosarita, Clementi,Rosanna, Cologna,Marina, Crifò, Tiziana, Cusumano, Giuseppina, Gottardi, Stefania, Innamorati, Claudia, Masè,Caterina, Postai,Daniela, Savoi, Daniela, Duranti, Sabrina, Lugli, Gabriele Andrea, Mancabelli, Leonardo, Turroni, Francesca, Ferrario, Chiara, Milani, Christian, Mangifesta, Marta, Anzalone, Rosaria, Viappiani, Alice, Yassour, Moran, Vlamakis, Hera, Xavier, Ramnik, Collado, María Carmen, Koren,Omry, Tateo, Saverio, Soffiati,Massimo, Pedrotti, Anna, Ventura, Marco, Huttenhower, Curtis, Bork, Peer, and Segata, Nicola

Abstract

The acquisition and development of the infant microbiome are key to establishing a healthy host-microbiome symbiosis. The maternal microbial reservoir is thought to play a crucial role in this process. However, the source and transmission routes of the infant pioneering microbes are poorly understood. To address this, we longitudinally sampled the microbiome of 25 mother-infant pairs across multiple body sites from birth up to 4 months postpartum. Strain-level metagenomic profiling showed a rapid influx of microbes at birth followed by strong selection during the first few days of life. Maternal skin and vaginal strains colonize only transiently, and the infant continues to acquire microbes from distinct maternal sources after birth. Maternal gut strains proved more persistent in the infant gut and ecologically better adapted than those acquired from other sources. Together, these data describe the mother-to-infant microbiome transmission routes that are integral in the development of the infant microbiome.

Published
2018

3. Output injection filtering redesign in high-gain observers

Author

Daniele Astolfi, Luca Zaccarian, Marc Jungers, Centre de Recherche en Automatique de Nancy (CRAN), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Équipe Méthodes et Algorithmes en Commande (LAAS-MAC), Laboratoire d'analyse et d'architecture des systèmes (LAAS), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse 1 Capitole (UT1)-Université Toulouse - Jean Jaurès (UT2J)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse 1 Capitole (UT1)-Université Toulouse - Jean Jaurès (UT2J), University of Trento [Trento], Region Grand-Est, CaRiTRo, grant PowerLyap, Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées, Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université Toulouse Capitole (UT Capitole), and Université de Toulouse (UT)

Subjects
0209 industrial biotechnology, High-gain antenna, Observer (quantum physics), Noise measurement, Computer science, 020208 electrical & electronic engineering, 02 engineering and technology, Filter (signal processing), Dynamical system, Term (time), Noise, 020901 industrial engineering & automation, Control theory, Convergence (routing), 0202 electrical engineering, electronic engineering, information engineering, [INFO.INFO-SY]Computer Science [cs]/Systems and Control [cs.SY]
Abstract

International audience; We propose a new paradigm to redesign high-gain observers in order to improve performances in the presence of measurement noise. In particular, instead of driving the observer by means of a standard output injection term, we filter it with a dynamical system having good filtering properties. In this first preliminary result we also select the filter in order to address numerical challenges.

Published
2018

4. Mother-to-Infant Microbial Transmission from Different Body Sites Shapes the Developing Infant Gut Microbiome

Author

Rosaria Anzalone, Massimo Soffiati, Sabrina Duranti, Hera Vlamakis, Rosanna Clementi, Stefania Gottardi, Omry Koren, Carmen Maria Collado, Nicola Segata, Leonardo Mancabelli, Curtis Huttenhower, Tiziana Crifò, Francesco Asnicar, Gabriele Andrea Lugli, Serena Manara, Pamela Ferretti, Francesco Beghini, Marta Mangifesta, Francesca Turroni, Rosarita Canto, Daniela Postai, Marina Cologna, Edoardo Pasolli, Alice Viappiani, Federica Armanini, Valentina Gorfer, Adrian Tett, Veronica De Sanctis, Roberto Bertorelli, Moran Yassour, Caterina Masè, Duy Tin Truong, Chiara Ferrario, Saverio Tateo, Sabina Fedi, Claudia Innamorati, Daniela Savoi, Marco Ventura, Moreno Zolfo, Ramnik J. Xavier, Anna Pedrotti, Peer Bork, Ilaria Bariletti, Christian Milani, Giuseppina Cusumano, European Commission, LEO Pharma Foundation, Fondazione Caritro, Ferretti, Pamela, Pasolli, Edoardo, Tett, Adrian, Asnicar, Francesco, Gorfer, Valentina, Fedi, Sabina, Armanini, Federica, Truong, Duy Tin, Manara, Serena, Zolfo, Moreno, Beghini, Francesco, Bertorelli, Roberto, De Sanctis, Veronica, Bariletti, Ilaria, Canto, Rosarita, Clementi, Rosanna, Cologna, Marina, Crifò, Tiziana, Cusumano, Giuseppina, Gottardi, Stefania, Innamorati, Claudia, Masè, Caterina, Postai, Daniela, Savoi, Daniela, Duranti, Sabrina, Lugli, Gabriele Andrea, Mancabelli, Leonardo, Turroni, Francesca, Ferrario, Chiara, Milani, Christian, Mangifesta, Marta, Anzalone, Rosaria, Viappiani, Alice, Yassour, Moran, Vlamakis, Hera, Xavier, Ramnik, Collado, Carmen Maria, Koren, Omry, Tateo, Saverio, Soffiati, Massimo, Pedrotti, Anna, Ventura, Marco, Huttenhower, Curti, Bork, Peer, and Segata, Nicola

Subjects
Mother-Child Relation, Adult, DNA, Bacterial, 0301 basic medicine, microbiome transmission, Time Factors, Time Factor, 030106 microbiology, Zoology, Longitudinal Studie, Biology, Microbiology, Article, Metagenomic, Feces, 03 medical and health sciences, infant microbiome, shotgun metagenomics, strain-level profiling, Parasitology, Virology, Humans, Longitudinal Studies, Microbiome, shotgun metagenomic, Skin, Mouth, Gastrointestinal Microbiome, Infant, Middle Aged, Mother-Child Relations, Gut microbiome, 3. Good health, Gastrointestinal Tract, 030104 developmental biology, Metagenomics, Vagina, Fece, Female, Shotgun metagenomics, Human
Abstract

Summary The acquisition and development of the infant microbiome are key to establishing a healthy host-microbiome symbiosis. The maternal microbial reservoir is thought to play a crucial role in this process. However, the source and transmission routes of the infant pioneering microbes are poorly understood. To address this, we longitudinally sampled the microbiome of 25 mother-infant pairs across multiple body sites from birth up to 4 months postpartum. Strain-level metagenomic profiling showed a rapid influx of microbes at birth followed by strong selection during the first few days of life. Maternal skin and vaginal strains colonize only transiently, and the infant continues to acquire microbes from distinct maternal sources after birth. Maternal gut strains proved more persistent in the infant gut and ecologically better adapted than those acquired from other sources. Together, these data describe the mother-to-infant microbiome transmission routes that are integral in the development of the infant microbiome., Graphical Abstract, Highlights • Strain-resolved metagenomics was used to track mother-to-infant microbiome transfer • Microbial strains from multiple maternal body sites transfer to the infant microbiome • The early microbial diversity in the infant gut is rapidly shaped by niche selection • The maternal gut microbiome is the source of the majority of transmitted strains, Ferretti et al. use metagenomics with strain-resolved computational profiling to characterize the transfer of microbes from mothers to their infants during their first 4 months of life. Multiple maternal body sites contribute to the developing infant microbiome, with maternal gut strains providing the largest contribution of colonizing microorganisms.

Published
2018

5. Constructive Preference Elicitation by Setwise Max-Margin Learning

Author

Teso, S., andrea passerini, Viappiani, P., Department of Information Engineering and Computer Science (University of Trento ) (DISI), University of Trento [Trento], DECISION, Laboratoire d'Informatique de Paris 6 (LIP6), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), ST was supported by the Caritro Foundation through project E62I15000530007. PV was supported by the Idex Sorbonne Universites under grant ANR-11-IDEX-0004-02, and Viappiani, Paolo

Subjects
[INFO.INFO-AI] Computer Science [cs]/Artificial Intelligence [cs.AI], FOS: Computer and information sciences, Computer Science - Learning, Artificial Intelligence (cs.AI), Statistics - Machine Learning, Computer Science - Artificial Intelligence, Machine Learning (stat.ML), Machine Learning (cs.LG), 68T05, [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI]
Abstract

In this paper we propose an approach to preference elicitation that is suitable to large configuration spaces beyond the reach of existing state-of-the-art approaches. Our setwise max-margin method can be viewed as a generalization of max-margin learning to sets, and can produce a set of "diverse" items that can be used to ask informative queries to the user. Moreover, the approach can encourage sparsity in the parameter space, in order to favor the assessment of utility towards combinations of weights that concentrate on just few features. We present a mixed integer linear programming formulation and show how our approach compares favourably with Bayesian preference elicitation alternatives and easily scales to realistic datasets., Comment: 7 pages. A conference version of this work is accepted by the 25th International Joint Conference on Artificial Intelligence (IJCAI-16)

Published
2016

6. Porous inorganic thin films from bridged silsesquioxane sol-gel precursors

Author

Stefano Schutzmann, Laura Brigo, Husen K. Kang, Cristiano Ferraris, Anna Pistore, Marco Faustini, Giovanna Brusatin, Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), CARITRO, and Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)

Subjects
Thermogravimetric analysis, Materials science, Analytical chemistry, Porous inorganic films, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, chemistry.chemical_compound, Differential thermal analysis, Materials Chemistry, Thin film, Environmental ellipsometric porosimetry, Porosity, Sol-gel, Bridged polysilsequioxanes, Porosimetry, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Silsesquioxane, 0104 chemical sciences, Electronic, Optical and Magnetic Materials, Chemical species, chemistry, Chemical engineering, Ceramics and Composites, 0210 nano-technology, Transmission electron microscopy
Abstract

International audience; A sol-gel process was exploited to produce porous inorganic thin films from phenyl-bridged silsesquioxanes. The evolution of both structural and optical properties of the starting hybrid so-gel films were monitored, during synthesis and successive thermal curing steps, by Fourier transform infrared (FT-IR) spectroscopy, differential thermal analysis (DTA), thermogravimetric analysis (TGA) and spectroscopic ellipsometry (SE). Involved chemical species, structural and chemical modifications were identified when thermal treatments at increasing temperatures in the range of 60-800 degrees C were applied to the hybrid films. The progressive formation of a crosslinked silica network, template elimination and film densification were observed, resulting in completely inorganic porous thin films of low refractive index. The distinctiveness of this system directly comes from the extremely controlled and uniform dispersion of the porogen at a molecular level, which is intrinsic to the bridged silsesquioxane precursor choice. A quantitative porosity analysis was performed by environmental ellipsometric porosimetry (EEP), studying inorganic film optical and mechanical properties under different relative humidity conditions. A transmission electron microscopy (TEM) in-situ characterization of porosity size and distribution confirms the presence of a spatially structured organization of pores of a few nanometers in diameter.

Published
2016
Full Text
View/download PDF

7. Boosting and Balancing Electron and Hole Mobility in Single- and Bilayer WSe 2 Devices via Tailored Molecular Functionalization

Author

Roberto Verucchi, Marco Gobbi, Sara Bonacchi, Emanuele Orgiu, Marc-Antoine Stoeckel, Paolo Samorì, Melanie Timpel, Ye Wang, Marco Vittorio Nardi, Tim Leydecker, Matilde Eredia, Institut de Science et d'ingénierie supramoléculaires (ISIS), Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), European Commission, Agence Nationale de la Recherche (France), China Scholarship Council, Fondazione Caritro, Natural Sciences and Engineering Research Council of Canada, Fonds de Recherche du Québec, Stoeckel, Marc-Antoine, Orgiu, Emanuele, Samorì, Paolo, Stoeckel, Marc-Antoine [0000-0002-6410-4058], Orgiu, Emanuele [0000-0002-8232-0950], and Samorì, Paolo [0000-0001-6256-8281]

Subjects
Electron mobility, Materials science, Chemical substance, WSe, General Physics and Astronomy, 2D material, Self-assembled monolayers, 02 engineering and technology, Electron, 010402 general chemistry, 01 natural sciences, ambipolar FETs, General Materials Science, Ambipolar diffusion, business.industry, Bilayer, Molecular functionalization, General Engineering, self-assembled monolayers, WSe2, 2D materials, molecular functionalization, 2, Self-assembled monolayer, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, Electron transport chain, 0104 chemical sciences, Semiconductor, Optoelectronics, 0210 nano-technology, business
Abstract

WSe2 is a layered ambipolar semiconductor enabling hole and electron transport, which renders it a suitable active component for logic circuitry. However, solid-state devices based on single- and bilayer WSe2 typically exhibit unipolar transport and poor electrical performance when conventional SiO2 dielectric and Au electrodes are used. Here, we show that silane-containing functional molecules form ordered monolayers on the top of the WSe2 surface, thereby boosting its electrical performance in single- and bilayer field-effect transistors. In particular, by employing SiO2 dielectric substrates and top Au electrodes, we measure unipolar mobility as high as μh = 150 cm2 V-1 s-1 and μe = 17.9 cm2 V-1 s-1 in WSe2 single-layer devices when ad hoc molecular monolayers are chosen. Additionally, by asymmetric double-side functionalization with two different molecules, we provide opposite polarity to the top and bottom layer of bilayer WSe2, demonstrating nearly balanced ambipolarity at the bilayer limit. Our results indicate that the controlled functionalization of the two sides of the WSe2 mono- and bilayer flakes with highly ordered molecular monolayers offers the possibility to simultaneously achieve energy level engineering and defect functionalization, representing a path toward deterministic control over charge transport in 2D materials., We acknowledge funding from the European Commission through the Graphene Flagship Core 2 project (GA-785219), the Marie Sklodowska-Curie IEF SUPER2D (GA-748971) and IEF-GALACTIC (GA-2014-628563), the Agence Nationale de la Recherche through the Labex projects CSC (ANR-10-LABX-0026 CSC) and NIE (ANR-11-LABX-0058 NIE) within the Investissement d’Avenir program (ANR-10-120 IDEX-0002-02), the International Center for Frontier Research in Chemistry (icFRC), as well as the Chinese Scholarship Council. M.V.N. and M.T. gratefully acknowledge the support by the CARITRO Foundation (project MILA, grant no. 2017.0369), Trento (Italy). E.O. is supported by the Natural Sciences and Engineering Research Council of Canada (NSERC) through an individual Discovery Grant and by Fonds de recherche du Quebec - Nature et Technologies (FRQNT).

Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results