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1. Effects of a new combination of nutraceuticals on postmenopausal symptoms and metabolic profile: a crossover, randomized, double-blind trial

Author

Trimarco V, Rozza F, Izzo R, De Leo V, Cappelli V, Riccardi C, and Di Carlo C

Subjects
menopause, nutraceuticals, cardiovascular risk, Gynecology and obstetrics, RG1-991
Abstract

Valentina Trimarco,1 Francesco Rozza,2 Raffaele Izzo,3 Vincenzo De Leo,4 Valentina Cappelli,4 Carla Riccardi,1 Costantino Di Carlo1 1Department of Neuroscience, Reproductive Sciences and Dentistry, 2Department of Biomedical Sciences, 3Department of Translational Medical Sciences, Federico II University of Naples, Naples, 4Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy Objectives: This study was designed to measure the beneficial effects of a combination of nutraceutics (NUT; AkP04, Morestril®, Akademy Pharma) containing soy isoflavones (80 mg), dry extract of Angelica sinensis (50 mg), dry extract of Morus alba leaf (200 mg) and magnesium (56.25 mg) in the relief of somatic, psychological, and urogenital symptoms in postmenopausal patients, using the validated Menopause Rating Scale (MRS) and cardiovascular risk factors.Materials and methods: A total of 43 symptomatic postmenopausal women (MRS ≥20) were enrolled in a crossover trial. After a 2-week run-in period, patients were randomized into two arms. One arm received probiotics plus placebo over 4 weeks, followed by a 4-week treatment with probiotics plus NUT. The second arm received probiotics plus NUT for 4 weeks, followed by a 4-week treatment with probiotics plus placebo.Results: After the NUT period, participants showed a significant reduction in MRS score (18.4±5.4) in comparison to baseline (28.4±5) and the placebo period (28±5.2) (P

Published
2016

3. Evaluation of the treatment with D-chiroinositol on levels of oxidative stress in pcos patients

Author

De Leo, V., La Marca, A., and Cappelli, V.

Subjects
Infertility, Inositol phosphoglycan, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Follicular fluid, medicine.disease_cause, Internal medicine, Follicular phase, medicine, oxidative stress, Polycystic ovary syndrome, chemistry.chemical_classification, Reactive oxygen species, In vitro fertilisation, Ovulation stimulation, business.industry, Insulin, ovulation stimulation, Oxidative stress, Obstetrics and Gynecology, Gynecology and obstetrics, medicine.disease, Polycystic ovary, follicular fluid, Endocrinology, Reproductive Medicine, chemistry, polycystic ovary syndrome, inositol phosphoglycan, RG1-991, business
Abstract

Recent studies on the pathophysiology of infertility have shown that oxidative stress (OS) can be one of the causal factors. The OS is, by definition, an imbalance between the production of reactive oxygen species and antioxidant defense systems. It seems that oxidative stress plays an important role in almost all phases of human reproduction. In fact, reactive oxygen species are involved in the modulation of a large spectrum of reproductive functions such as oocyte maturation, ovarian steroidogenesis, corpus luteum functions and are involved in the processes of fertilization, embryo development and pregnancy, but also in some diseases that cause infertility. Polycystic ovary syndrome (PCOS) has recently been associated with increased oxidative stress, often put in relation to the syndrome's typical metabolic disorder. Inositol is an intracellular mediator of insulin, currently much used as a therapeutic agent in PCOS. While its main action takes place via insulin sensitization, little is known about the possible effects of other disorders, such as oxidative stress, associated with PCOS. Purpose of study was therefore to assess the effect of D-chiro-inositol on the state of oxidative stress in the follicular fluid of women with PCOS. Materials and methods. Follicular fluids were obtained from women who have turned to the Center for Diagnosis and Treatment of Sterility of Obstetrics and Gynecology of the University Hospital of Siena and Modena diagnosed with PCOS. The women were treated with D-chiro-inositol (500 mg x 2 per day) for 3 months before being subjected to cycles of in vitro fertilization. The state of oxidative stress was measured by marking of free thiol groups of proteins in the follicular fluid with 3-(N-maleimidopropionyl)-biocytin. Results. In our study we obtained a lesser presence of free thiol protein groups equal to 77.8% in the follicular fluid of women with PCOS not treated with D-chiro-inositol, compared to patients who instead have carried out such treatment. Conclusions. These results suggest that in PCOS women there is an increase of the oxidation of thiol groups of proteins follicular, correlated to a progressive increase of the oxidative stress and that the administration of D-chiro-inositol in patients with this disease seems to reduce the oxidation of thiol groups

Published
2019

4. Risk factors and action thresholds for the novel coronavirus pandemic. Insights from the Italian Society of Nephrology COVID-19 Survey

Author

Nordio, M., Reboldi, G., Di Napoli, A., Quintaliani, G., Alberici, F., Postorino, M., Aucella, F., Messa, P., Brunori, G., Bosco, M., Malberti, F., Mandreoli, M., Mazzaferro, S., Movilli, E., Ravera, M., Salomone, M., Santoro, D., Postorinolimido, M. A., Bonomini, M., Stingone, A., Maccarone, M., Di Loreto, E., Stacchiotti, L., Malandra, R., Chiarella, S., D'Agostino, F., Fuiano, G., Nicodemo, L., Bonofiglio, R., Greco, S., Mallamaci, F., Barreca, E., Caserta, C., Bruzzese, V., Galati, D., Tramontana, D., Viscione, M., Chiuchiolo, L., Tuccillo, S., Sepe, M., Vitale, F., Ciriana, E., Martignetti, V., Caserta, D., Stizzo, A., Romano, A., Iulianiello, G., Cascone, E., Minicone, P., Chiricone, D., Delgado, G., Barbato, A., Celentano, S., Molfino, I., Coppola, S., Raiola, I., Abategiovanni, M., Borrelli, S., Margherita, C., Bruno, F., Ida, M., Aliperti, E., Potito, D., Cuomo, G., De Luca, M., Merola, M., Botta, C., Garofalo, G., Alinei, P., Paglionico, C., Roano, M., Vitale, S., Ierardi, R., Fimiani, V., Conte, G., Di Natale, G., Romano, M., Di Marino, V., Scafarto, A., Meccariello, S., Pecoraro, C., Di Stazio, E., Di Meglio, E., Cuomo, A., Maresca, B., Rotaia, E., Capasso, G., Auricchio, M., Pluvio, C., Maddalena, L., De Maio, A., Palladino, G., Buono, F., Gigliotti, G., Mancini, E., La Manna, G., Storari, A., Mosconi, G., Cappelli, G., Scarpioni, R., Gregorini, M., Rigotti, A., Mancini, W., Bianco, F., Boscutti, G., Amici, G., Tosto, M., Fini, R., Pace, G., Cioffi, A., Boccia, E., Di Lullo, L., Di Zazzo, G., Simonelli, R., Bondatti, F., Miglio, L., Rifici, N., Treglia, A., Muci, M., Baldinelli, G., Rizzi, E., Lonzi, M., De Cicco, C., Forte, F., De Paolis, P., Grandaliano, Giuseppe, Cuzziol, C., Torre, V. M., Sfregola, P., Rossi, V., Fabio, G., Flammini, A., Filippini, A., Onorato, L., Vendola, F., Di Daniela, N., Alfarone, C., Scabbia, L., Ferrazzano, M., Grotta, B. D., Gamberini, M., Fazzari, L., Mene, P., Morgia, A., Catucci, A., Palumbo, R., Puliti, M., Marinelli, R., Polito, P., Marrocco, F., Morabito, S., Rocca, R., Nazzaro, L., Lavini, R., Iamundo, V., Chiappini, M., Casarci, M., Morosetti, M., Hassan, S., Firmi, G., Galliani, M., Serraiocco, M., Feriozzi, S., Valentini, W., Sacco, P., Garibotto, G., Cappelli, V., Saffioti, C., Repetto, M., Rolla, D., Lorenz, M., Pedrini, L., Polonioli, D., Galli, E., Ruggenenti, P., Scolari, F., Bove, S., Costantino, E., Bracchi, M., Mangano, S., Depetri, G., La Milia, V., Farina, M., Zecchini, S., Savino, R., Melandri, M., Guastoni, C., Paparella, M., Gallieni, M., Minetti, E., Bisegna, S., Righetti, M., Badalamenti, S., Alberghini, E., Bertoli, S., Fabbrini, P., Albrizio, P., Rampino, T., Colturi, C., Rombola, G., Lucatello, A., Guerrini, E., Ranghino, A., Lenci, F., Fanciulli, E., Santarelli, S., Damiani, C., Garofalo, D., Sopranzi, F., Santoferrara, A., Di Luca, M., Galiotta, P., Brigante, M., Manganaro, M., Maffei, S., Berto, I., Besso, L., Viglino, G., Cusinato, S., Chiarinottichiappero, D. F., Tognarelli, G., Gianoglio, B., Forneris, G., Biancone, L., Savoldi, S., Vitale, C., Boero, R., Filiberti, O., Borzumati, M., Gesualdo, L., Lomonte, C., Gernone, G., Pallotta, G., Di Paolo, S., Vernaglione, L., Specchio, A., Stallone, G., Dell'Aquila, R., Sandri, G., Russo, F., Napoli, M., Marangi, A., Morrone, L., Di Stratis, C., Fresu, A., Cicu, F., Murtas, S., Manca, O., Pani, A., Pilloni, M., Pistis, R., Cadoni, M., Contu, B., Logias, F., Ivaldi, R., Fancello, S., Cossu, M., Lepori, G., Vittoria, S., Battiati, E., Arnone, M., Rome, M., Barbera, A., Granata, A., Collura, G., Dico, C. L., Pugliese, G., Di Natale, E., Rizzari, G., Cottone, L., Longo, N., Battaglia, G., Marcantoni, C., Giannetto, G., Tumino, G., Randazzo, F., Bellissimo, L., Faro, F. L., Grippaldi, F., Urso, S., Quattrone, G., Todaro, I., Vincenzo, D., Murgo, A., Masuzzo, M., Pisacane, A., Monardo, P., Pontorierro, M., Quari, C., Bauro, A., Chimenz, R. R., Alfio, D., Girasole, F., Cascio, A. L., Caviglia, A., Tornese, F., Sirna, F., Altieri, C., Cusumano, R., Saveriano, V., La Corte, A., Locascio, G., Rotolo, U., Musso, S., Risuglia, L., Blanco, G., Minardo, G., Castellino, S., Zappulla, Z., Randone, S., Di Francesca, M., Cassetti, C. C., Oddo, G., Buscaino, G., Mucaria, F., Barraco, V. I., Di Martino, A., Rallo, D., Dani, L., Campolo, G., Manescalchi, F., Biagini, M., Agate, M., Panichi, V., Casani, A., Traversari, L., Garosi, G., Tabbi, M., Selvi, A., Cencioni, L., Fagugli, R., Timio, F., Leveque, A., Manes, M., Mennella, G., Calo, L., Fiorini, F., Abaterusso, C., Calzavara, P., Meneghel, G., Bonesso, C., Gambaro, G., Gammaro, L., Rugiu, C., Ronco, C., Nordio M., Reboldi G., Di Napoli A., Quintaliani G., Alberici F., Postorino M., Aucella F., Messa P., Brunori G., Bosco M., Malberti F., Mandreoli M., Mazzaferro S., Movilli E., Ravera M., Salomone M., Santoro D., PostorinoLimido M.A., Bonomini M., Stingone A., Maccarone M., Di Loreto E., Stacchiotti L., Malandra R., Chiarella S., D'Agostino F., Fuiano G., Nicodemo L., Bonofiglio R., Greco S., Mallamaci F., Barreca E., Caserta C., Bruzzese V., Galati D., Tramontana D., Viscione M., Chiuchiolo L., Tuccillo S., Sepe M., Vitale F., Ciriana E., Martignetti V., Caserta D., Stizzo A., Romano A., Iulianiello G., Cascone E., Minicone P., Chiricone D., Delgado G., Barbato A., Celentano S., Molfino I., Coppola S., Raiola I., Abategiovanni M., Borrelli S., Margherita C., Bruno F., Ida M., Aliperti E., Potito D., Cuomo G., De Luca M., Merola M., Botta C., Garofalo G., Alinei P., Paglionico C., Roano M., Vitale S., Ierardi R., Fimiani V., Conte G., Di Natale G., Romano M., Di Marino V., Scafarto A., Meccariello S., Pecoraro C., Di Stazio E., Di Meglio E., Cuomo A., Maresca B., Rotaia E., Capasso G., Auricchio M., Pluvio C., Maddalena L., De Maio A., Palladino G., Buono F., Gigliotti G., Mancini E., La Manna G., Storari A., Mosconi G., Cappelli G., Scarpioni R., Gregorini M., Rigotti A., Mancini W., Bianco F., Boscutti G., Amici G., Tosto M., Fini R., Pace G., Cioffi A., Boccia E., Di Lullo L., Di Zazzo G., Simonelli R., Bondatti F., Miglio L., Rifici N., Treglia A., Muci M., Baldinelli G., Rizzi E., Lonzi M., De Cicco C., Forte F., De Paolis P., Grandaliano G., Cuzziol C., Torre V.M., Sfregola P., Rossi V., Fabio G., Flammini A., Filippini A., Onorato L., Vendola F., Di Daniela N., Alfarone C., Scabbia L., Ferrazzano M., Grotta B.D., Gamberini M., Fazzari L., Mene P., Morgia A., Catucci A., Palumbo R., Puliti M., Marinelli R., Polito P., Marrocco F., Morabito S., Rocca R., Nazzaro L., Lavini R., Iamundo V., Chiappini M., Casarci M., Morosetti M., Hassan S., Firmi G., Galliani M., Serraiocco M., Feriozzi S., Valentini W., Sacco P., Garibotto G., Cappelli V., Saffioti C., Repetto M., Rolla D., Lorenz M., Pedrini L., Polonioli D., Galli E., Ruggenenti P., Scolari F., Bove S., Costantino E., Bracchi M., Mangano S., Depetri G., La Milia V., Farina M., Zecchini S., Savino R., Melandri M., Guastoni C., Paparella M., Gallieni M., Minetti E., Bisegna S., Righetti M., Badalamenti S., Alberghini E., Bertoli S., Fabbrini P., Albrizio P., Rampino T., Colturi C., Rombola G., Lucatello A., Guerrini E., Ranghino A., Lenci F., Fanciulli E., Santarelli S., Damiani C., Garofalo D., Sopranzi F., Santoferrara A., Di Luca M., Galiotta P., Brigante M., Manganaro M., Maffei S., Berto I., Besso L., Viglino G., Cusinato S., ChiarinottiChiappero D.F., Tognarelli G., Gianoglio B., Forneris G., Biancone L., Savoldi S., Vitale C., Boero R., Filiberti O., Borzumati M., Gesualdo L., Lomonte C., Gernone G., Pallotta G., Di Paolo S., Vernaglione L., Specchio A., Stallone G., Dell'Aquila R., Sandri G., Russo F., Napoli M., Marangi A., Morrone L., Di Stratis C., Fresu A., Cicu F., Murtas S., Manca O., Pani A., Pilloni M., Pistis R., Cadoni M., Contu B., Logias F., Ivaldi R., Fancello S., Cossu M., Lepori G., Vittoria S., Battiati E., Arnone M., Rome M., Barbera A., Granata A., Collura G., Dico C.L., Pugliese G., Di Natale E., Rizzari G., Cottone L., Longo N., Battaglia G., Marcantoni C., Giannetto G., Tumino G., Randazzo F., Bellissimo L., Faro F.L., Grippaldi F., Urso S., Quattrone G., Todaro I., Vincenzo D., Murgo A., Masuzzo M., Pisacane A., Monardo P., Pontorierro M., Quari C., Bauro A., Chimenz R.R., Alfio D., Girasole F., Cascio A.L., Caviglia A., Tornese F., Sirna F., Altieri C., Cusumano R., Saveriano V., La Corte A., Locascio G., Rotolo U., Musso S., Risuglia L., Blanco G., Minardo G., Castellino S., Zappulla Z., Randone S., Di Francesca M., Cassetti C.C., Oddo G., Buscaino G., Mucaria F., Barraco V.I., Di Martino A., Rallo D., Dani L., Campolo G., Manescalchi F., Biagini M., Agate M., Panichi V., Casani A., Traversari L., Garosi G., Tabbi M., Selvi A., Cencioni L., Fagugli R., Timio F., Leveque A., Manes M., Mennella G., Calo L., Fiorini F., Abaterusso C., Calzavara P., Meneghel G., Bonesso C., Gambaro G., Gammaro L., Rugiu C., and Ronco C.

Subjects
Male, Contextual analysis, medicine.medical_treatment, Population, 030232 urology & nephrology, Recursive partitioning, 030204 cardiovascular system & hematology, Rate ratio, Risk Assessment, 03 medical and health sciences, 0302 clinical medicine, Classification tree, COVID-19, Renal replacement therapy, Risk Factors, Medical, Surveys and Questionnaires, Health care, medicine, Settore MED/14 - NEFROLOGIA, Humans, education, Pandemics, Societies, Medical, Female, Italy, Nephrology, education.field_of_study, business.industry, Multilevel model, Decision rule, Confidence interval, Original Article, Hemodialysis, business, Contextual analysi, Societies, Demography
Abstract

Background and aim: Over 80% (365/454) of the nation’s centers participated in the Italian Society of Nephrology COVID-19 Survey. Out of 60,441 surveyed patients, 1368 were infected as of April 23rd, 2020. However, center-specific proportions showed substantial heterogeneity. We therefore undertook new analyses to identify explanatory factors, contextual effects, and decision rules for infection containment. Methods: We investigated fixed factors and contextual effects by multilevel modeling. Classification and Regression Tree (CART) analysis was used to develop decision rules. Results: Increased positivity among hemodialysis patients was predicted by center location [incidence rate ratio (IRR) 1.34, 95% confidence interval (CI) 1.20–1.51], positive healthcare workers (IRR 1.09, 95% CI 1.02–1.17), test-all policy (IRR 5.94, 95% CI 3.36–10.45), and infected proportion in the general population (IRR 1.002, 95% CI 1.001–1.003) (all p < 0.01). Conversely, lockdown duration exerted a protective effect (IRR 0.95, 95% CI 0.94–0.98) (p < 0.01). The province-contextual effects accounted for 10% of the total variability. Predictive factors for peritoneal dialysis and transplant cases were center location and infected proportion in the general population. Using recursive partitioning, we identified decision thresholds at general population incidence ≥ 229 per 100,000 and at ≥ 3 positive healthcare workers. Conclusions: Beyond fixed risk factors, shared with the general population, the increased and heterogeneous proportion of positive patients is related to the center’s testing policy, the number of positive patients and healthcare workers, and to contextual effects at the province level. Nephrology centers may adopt simple decision rules to strengthen containment measures timely.

Published
2021

6. Metformin doses and body mass index: clinical outcomes in insulin resistant polycystic ovary syndrome women

Author

Morgante, G., Massaro, M. G., Scolaro, V., Cappelli, V., Luddi, A., Troia, L., and De Leo, V.

Subjects
Adult, Dose-Response Relationship, Drug, Metformin, Body Mass Index, Cohort Studies, HOMA index, Hyperandrogenism, Insulin resistance, PCOS, Young Adult, Treatment Outcome, Humans, Hypoglycemic Agents, Female, Prospective Studies, Insulin Resistance, Polycystic Ovary Syndrome
Abstract

PCOS is the most common endocrinopathy among reproductive age women. Approximately 60% of PCOS women have insulin resistance. While the efficacy of metformin in reducing insulin resistance and decreasing androgen level has been widely validated, there is no agreement on the dose of metformin to be used.Prospective non-randomized cohort study of 108 insulin resistant, overweight and obese PCOS women, aged between 22 and 35 years. All patients received 1500 mg of metformin (500 mg x 3 times/day) for the first 6 months. At the end of this period, the patients' HOMA index was evaluated. In subjects, who did not demonstrate normalization of the HOMA index, the dose was increased to 2500 mg/day (500 mg at breakfast and 1000 mg at lunch and dinner) for additional 6 months. The hormonal blood profile, fasting insulin and fasting glucose levels, HOMA index, anthropometric assessment, pelvic ultrasound, FAI index and cholesterol were evaluated.Overall results showed a good response to metformin therapy in insulin-resistant PCOS patients with BMI25, while in patients with higher BMI (31.15 ± 0.40), no normalization of HOMA was found. At the higher dose of metformin, obese patients achieved a good response to therapy, with improvement in BMI, menstrual pattern, cholesterol levels and hyperandrogenism.Our results demonstrate a correlation between the required dose of metformin, BMI and hyperandrogenism. The dose of metformin should be adjusted to patients' BMI in order to obtain significant results in terms of clinical, metabolic and hormonal responses.

Published
2020

11. Maximum speed of shortening and ATPase activity in atrial and ventricular myocardia of hyperthyroid rats

Author

Bottinelli, R., Canepari, M., Cappelli, V., and Reggiani, C.

Subjects
Hyperthyroidism -- Research, Adenosine triphosphatase -- Physiological aspects, Heart muscle -- Observations, Biological sciences
Abstract

The atrial and ventricular myocardia in hyperthyroid rats demonstrate identical functioning of myofibrillar adenosine triphosphatase at conditions of high and low ionic strengths. This result was predicted for the two myocardia when myosin heavy chain isoforms are involved. The shortening is faster in atrial myocardium than in ventricular myocardium because of tissue-specific isoforms of myosin light chains.

Published
1995

12. Abstracts of the XVIII European Conference on Muscle and Motility: De Blije Werelt, Lunteren, The Netherlands September 12–16, 1989

Author

Nesterov, V. P., Peiper, U., Hiller, J., Krienke, B., Schüttler, K., Szymanski, C., Bottinelli, R., Cappelli, V., Minelli, R., Reggiani, C., Schiaffino, S., Carlhoff, D., D'Haese, J., Dabrowska, R., Nowak, E., Borovikov, Y. S., Cummins, P., Russell, G., McLoughlin, D., Cummins, B., Bonet, A., Harricane, M. C., Audemard, E., Mornet, D., Ropert, S., Cavaillé, F., Redwood, C. S., Bryan, J., Cross, R. A., Kendrick-Jones, J., Marston, S. B., Taggart, M., Marston, S., Makuch, R., Stokarska, G., Dabrowska, R., Cecchi, G., Colomo, F., Poggesi, C., Tesi, C., Puceat, M., Clement, O., Lechene, P., Pelosin, J. -M., Ventura-Clapter, R., Vassort, G., Fischer, W., Pfitzer, G., Ankrett, R. J., Rowe, A. J., Bagshaw, C. R., Perry, S. V., Hebisch, S., Levine, B., Moir, A. J. G., Leszyk, J., Derancourt, J., Patcheil, V., Cavadore, C., Collins, J. H., Swiderek, K., Jaquet, K., Mittmann, K., Meyer, H. E., Heilmeyer, Jr, L. M. J., Travers, F., Barman, T., Duvert, M., Grandier-Vazeille, X., Verna, A., Dan-Goor, M., Mühlrad, A., Muhlrad, A., Polzar, B., Kießling, P., Mannherz, H. G., Lehmann-Klose, S., Gröschel-Stewart, U., Bettache, N., Bertrand, R., Kassab, R., Roulet, A., Cardinaud, R., Harford, J. J., Squire, J. M., Maeda, Y., Chew, M. W. K., Huber, Pia, Schaub, Marcus C., Pierobon-Bormioli, S., Betto, R., Ceoldo, S., Salviati, G., Martinez, I., Ofstad, R., Olsen, R. L., Trinick, J., Barlow, D., Gautel, M., Gibson, T., Labeit, S., Leonard, K., Wardale, J., Whiting, A., Draeger, A., Barth, M., Herzog, M., Gimona, M., Small, J. V., Stelzer, E., Amos, B., Ikebe, M., Bernengo, J. C., Rinne, Bettina, Wray, John S., Poole, K. J. V., Goody, R. S., Thomas, Daniel, Rowe, Arthur, Schröder, R. R., Hofmann, W., Müller, U. C., Menetret, J. -F., Wray, J. S., Lakey, A., Tichelaar, W., Ferguson, C., Bullard, B., Kabsch, W., Pai, E. F., Suck, D., Holmes, K. C., Jarosch, Robert, van Mastrigt, R., Pollack, Gerald H., Horowitz, Arie, Anderl, R., Kuhn, H. J., Burton, K., Jung, D. W. G., Blangé, T., Treijtel, B. W., Bagni, M. A., Garzella, P., Huxley, A. F., Beckers-Bleukx, G., Maréchal, G., Bershitsky, S. Y., Tsaturyan, A. K., Woodward, S. K. A., Eccleston, J. F., Geeves, M. A., Knight, Peter, Fortune, Neil, Geeves, Mike, Arner, A., Arheden, H., Lombardi, V., Piazzesi, G., Stienen, G. J. M., Elzinga, G., de Beer, E. L., van Buuren, K. J. H., ten Kate, Y. J., Grundeman, R. L. F., Schiereck, P., Trombitas, K., Versteeg, P. G. A., Rowe, Arthur J., Bolger, Paul, van der Laarse, W. J., Diegenbach, P. C., Flitney, F. W., Jones, D. A., Hatfaludy, S., Shansky, J., Smiley, B., Vandenburgh, H. H., de Haan, A., Lodder, M. A. N., Berquin, A., Lebacq, J., Curtin, N. A., Woledge, R. C., Hellstrand, P., Lönnbro, P., Wadsö, I., Lammertse, T. S., Zaremba, R., Daut, J., Woledge, R. C., Kushmerick, M. J., McFarland, E., Lyons, G. E., Sassoon, D., Ontell, M., and Buckingham, M. E.

Published
1990
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14. Natural molecules for the therapy of hyperandrogenism and metabolic disorders in PCOS

Author

Cappelli, V., Musacchio, M. C., Bulfoni, A., Giuseppe MORGANTE, and Leo, V.

Subjects
Biological Products, Metabolic Diseases, Humans, Female, Biological Products, Female, Humans, Hyperandrogenism, Metabolic Diseases, Polycystic Ovary Syndrome, Hyperandrogenism, Polycystic Ovary Syndrome
Abstract

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy of women of reproductive age and a complex endocrine condition, due to its heterogeneity and uncertainty about its etiology. However, PCOS is also associated with other metabolic abnormalities such as insulin resistance, impaired glucose tolerance, and diabetes. There are few medications that are approved for the most common symptoms of PCOS, leading to the off-label use of medications that were approved for other indications. One of the most common medications being used off label for PCOS is metformin. Research of other effective therapeutic options has included the utility of inositol.A systematic literature search of PubMed was performed using the following combination of terms: 'PCOS', 'hyperandrogenism' 'inositol', 'natural molecules'. Only papers published between 2000 and 2016 were included in our analysis. The present review analyzes all aspects of the choice of natural molecules in the treatment of hyperandrogenism and metabolic disorders in PCOS women.The rationale underlying the use of inositols as a therapeutic application in PCOS derives from their activities as insulin mimetic agents and their salutary effects on metabolism and hyperandrogenism without side effects.In this review will discuss the role of a number of natural associations between inositol and different substances in the treatment of hyperandrogenic symptoms in PCOS women.

Published
2017

15. Evaluation of the effects of a natural dietary supplement with cranberry, noxamicina and d-mannose in recurrent urinary infections in perimenopausal women [Valutazione degli effetti di un integratore naturale a base di cranberry, Noxamicina® e D‑mannosio nelle infezioni urinarie recidivanti in donne in perimenopausa]

Author

De Leo, V., Cappelli, V., Massaro, M. G., Tosti, C., and Morgante, G.

Subjects
Adult, Plant Extracts, Middle Aged, Perimenopause, Cystitis, Dysuria, Mannose, Postmenopause, Vaccinium macrocarpon, Female, Humans, Quality of Life, Treatment Outcome, Urinary Tract Infections, Dietary Supplements
Published
2017

18. Polycystic ovary syndrome (PCOS) and hyperandrogenism: the role of a new natural association

Author

Giuseppe MORGANTE, Cappelli, V., Di Sabatino, A., Massaro, M. G., and Leo, V.

Subjects
Adult, Hirsutism, Dose-Response Relationship, Drug, Thioctic Acid, Antioxidants, Young Adult, Humans, Drug Therapy, Combination, Female, Lovastatin, Insulin Resistance, Hyperandrogenism, Inositol, Dyslipidemias, Polycystic Ovary Syndrome
Abstract

Polycystic ovary syndrome (PCOS) affects 5-10% of women of childbearing age and manifests itself through oligomenorrhea, anovulation, hirsutism, micro-polycystic ovaries. Insulin resistance is a characteristic of PCOS patients and is more pronounced in obese patients. Insulin resistance and consequent hyperinsulinemia are related to many aspects of the syndrome such as hyperandrogenism, reproductive disorders, acne and hirsutism. In the long-term it may increase the risk of cardiovascular disease and negatively affect lipid profile and blood pressure. Changes in lifestyle and diet can partially improve these aspects. The use of insulin-sensitizing drugs such as metformin often normalises the menstrual cycle, improving hyperandrogenism and, subsequently, the response to ovulation induction therapies. New molecules have recently been marketed, that produce the same results, but without the side-effects. One of these is myo-inositol, a new insulin-sensitizing molecule which has been successfully administered to women suffering from PCOS. Associations between inositol and other compounds that can increase the therapeutic effect have been proposed. Of these, we found to be interesting the association with monacolin K, a natural statin that reduces cholesterol levels starting point of the synthesis of steroids, including androgens, and lipoic acid, known for its anti-inflammatory, antioxidant and insulin-sensitizing activity. We decided to assess the efficacy of the product.We recruited 30 women aged between 24 and 32 years suffering from PCOS with insulin resistance, HOMA index2.5 and no other endocrine diseases. The following were assessed: Body Mass Index (BMI), characteristics of menstrual cycles, lipid profile (total cholesterol, and HDL), androgens (total testosterone and androstenedione). The patients were also assessed for the degree of hirsutism using the Ferriman-Gallwey Score8. The subjects were divided into two groups: Group A, treated with an association of 1 g myo-inositol, 5 mg monacolin K and 400 mg lipoic acid for 6 months; Group B, treated with a double dosage of 2 g myo-inositol, 10 mg monacolin K, 800 mg lipoic acid for 6 months.The results have shown good efficacy of both dosages, although women treated with a double dosage of myo-inositol, monacolin K and lipoic acid showed a significantly greater improvement in terms of lipid parameters and those connected with hyperandrogenism.This new myo-inositol, monacolin K and lipoic acid association contains appropriate substances to contrast various etiopathogenic elements responsible for the onset of PCOS and the symptoms of hyperandrogenism and dyslipidemia related to it.

Published
2015

20. Effects of the [[Beta].sub.2]-agonist clenbuterol on respiratory and limb uscles of weaning rats

Author

POLLA, B., CAPPELLI, V., MORELLO, F., PELLEGRINO, M. A., BOSCHI, F., PASTORIS, O., and REGGIANI, C.

Subjects
Clenbuterol -- Physiological aspects, Muscles -- Growth, Muscle contraction -- Physiological aspects, Rats as laboratory animals -- Physiological aspects, Biological sciences
Abstract

Polla, B., V. Cappelli, F. Morello, M. A. Pellegrino, F. Boschi, O. Pastoris, and C. Reggiani. Effects of the [[Beta].sub.2]-agonist clenbuterol on respiratory and limb muscles of weaning rats. Am J Physiol Regulatory Integrative Comp Physiol 280: R862-R869, 2001.--The aim of this study was to analyze the effects of chronic administration of the [[Beta].sub.2]-agonist clenbuterol (1.5 mg [multiplied by] [kg.sup.-1] [multiplied by] [day.sup.-1] for 4 wk in the drinking water) on respiratory (diaphragm and parasternal intercostal) and hindlimb (tibialis and soleus) muscles in young rats during postnatal development (21 to 49 postnatal days). The treatment resulted in very little stimulation of muscle growth. Significant slow-to-fast transitions in the expression of myosin heavy chain isoforms and significant increases in the myofibrillar ATPase activity were found in the diaphragm and soleus, whereas tibialis anterior and intercostal muscles did not show any significant fiber-type alteration. Decrease of oxidative enzyme activities and increase of glycolytic enzyme activities were also observed. It is concluded that whereas the growth stimulation is age dependent and only detectable in adult rats, the fiber-type transformation is also present in weaning rats and particularly evident in the soleus and diaphragm. The fiber-type transformation caused by clenbuterol might lead to an enhancement of contractile performance and also to a reduced resistance to fatigue. muscle; myosin isoforms; muscle metabolism; [Beta]-adrenoreceptors; muscle development

Published
2001

23. [Evaluation of a new association between insulin-sensitizers and α-lipoic acid in obese women affected by PCOS]

Author

Cappelli V, Di Sabatino A, Mc, Musacchio, and Vincenzo De Leo

Subjects
Adult, Blood Glucose, Thioctic Acid, Severity of Illness Index, Antioxidants, Metformin, Body Mass Index, Electron Transport, Young Adult, Treatment Outcome, Homeostasis, Humans, Drug Therapy, Combination, Female, Obesity, Insulin Resistance, Gonadal Steroid Hormones, Inositol, Polycystic Ovary Syndrome
Abstract

Polycystic ovary syndrome (PCOS) is a multifactorial pathology affecting 7-10% of the female population. Usually occurs with oligo/amenorrhea, anovulation, hirsutism, polycystic ovaries. Hyperinsulinemia associated with insulin resistance has been causally linked to all features of the syndrome. It has been demonstrated that by reducing hyperinsulinemia, in particular with the administration of metformin, insulin-lowering agents might improve endocrine and reproductive abnormalities in PCOS patients.Original association between myo-inositol and alpha-lipoic acid, has recently been successfully administered in women with PCOS. The α-lipoic acid is a powerful natural antioxidant and an enzyme cofactor of the mitochondrial respiratory chain, is found to be a substance capable of improving glycemic control in patients with type II diabetes. In our study we compared two groups: group A, treated with metformin (3 g) and group B treated with metformin (1.7 g), myo-inositol and alpha-lipoic acid.The results of this study demonstrated a good efficacy of both treatments, although in the group treated with the combination of metformin/myo-inositol/alpha-lipoic acid improvement in hyperandrogenism, BMI and HOMA index were significantly better.Thus, the association metformin/myo-inositol/alpha-lipoic acid represents an excellent therapy choice to suggest to those obese women affected by PCOS who do not want to take hormones and neither to have any severe side effect.

Published
2013

27. Therapeutic approach for metabolic disorders and infertility in women with PCOS.

Author

Morgante, G., Massaro, M. G., Di Sabatino, A., Cappelli, V., and De Leo, V.

Subjects
INFERTILITY treatment, POLYCYSTIC ovary syndrome, HYPERTRICHOSIS, METABOLIC disorder treatment, BODY weight
Abstract

Copyright of Gynecological Endocrinology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2018
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28. Evaluation of the treatment with D-chiro-inositol on levels of oxidative stress in PCOS patients [Valutazione del trattamento con D-chiro-inositolo sui livelli di stress ossidativo nelle pazienti con PCOS]

Author

Vincenzo De Leo, La Marca, A., Cappelli, V., Stendardi, A., Focarelli, R., Musacchio, M. C., and Piomboni, P.

Subjects
Adult, Inositol Phosphates, Ovulation induction, Oocyte Retrieval, Fertilization in Vitro, Follicular fluid, Antioxidants, Maleimides, Ovulation Induction, Polysaccharides, Pregnancy, Humans, Sulfhydryl Compounds, Inositol phosphate glycan, Polycystic ovary syndrome, Blotting, Lysine, Blotting, Western, Female, Follicular Fluid, Isoelectric Focusing, Oxidation-Reduction, Oxidative Stress, Polycystic Ovary Syndrome, Proteins, Oxidative stress, Western
Published
2012

30. [Metabolic acidosis in patients with chronic kidney diseases: why and when to treat it?]

Author

Sofia A, Cappelli V, Valli A, and GIACOMO GARIBOTTO

Subjects
Inflammation, Leptin, Disease Progression, Humans, Kidney Failure, Chronic, Acidosis, Renal Tubular, Acidosis
Abstract

Metabolic acidosis is a common complication in patients with advanced chronic renal diseases and dialytic treatments are unable to correct it completely. In hemodialysis (HD) patients, severe metabolic acidosis is associated with an increased risk of death. Evidence from several experimental studies suggests that even mild metabolic acidosis is associated with systemic effects. Acidosis is implicated in endocrine changes and has negative repercussions on bone and protein metabolism. In addition, recent observations suggest that acidosis triggers inflammation and accelerates the progression of chronic kidney diseases. As a contradictory finding, acidosis can reduce circulating leptin. Clinical studies on the nutritional effects of metabolic acidosis correction have shown mildly favorable effects. Taking into account the systemic effects of metabolic acidosis it is suggested that even mild metabolic acidosis is corrected. However, the new findings concerning the systemic effects of acidosis must be evaluated in controlled trials.

Published
2005

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