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2 results on '"CANDIDA-ALBICANS YEAST"'

1. Differential IL-17 production and mannan recognition contribute to fungal pathogenicity and commensalism

Author

Mirela Kuka, Giorgio Napolitani, Maria Torcia, Luca Beltrame, C. De Filippo, Alessandra Cambi, Ugo D'Oro, Lisa Rizzetto, Mihai G. Netea, Duccio Cavalieri, Kuka, Mirela, Rizzetto, L, De Filippo, C, Cambi, A, Netea, Mg, Beltrame, L, Napolitani, G, Torcia, Mg, D'Oro, U, and Cavalieri, D.

Subjects
CD4-Positive T-Lymphocytes, Hypha, Immunology, Saccharomyces cerevisiae, Hyphae, Monocytes, Microbiology, Mannans, Invasive mycoses and compromised host [N4i 2], 03 medical and health sciences, Immune system, Cell Wall, Immune Regulation [NCMLS 2], Candida albicans, Carbohydrate Conformation, Humans, Immunology and Allergy, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), 030304 developmental biology, Mannan, 0303 health sciences, biology, 030306 microbiology, Interleukin-17, fungi, Cell Differentiation, Dendritic Cells, Spores, Fungal, Th1 Cells, biology.organism_classification, Interleukin-12, Corpus albicans, Yeast, DC-SIGN, HUMAN DENDRITIC CELLS, CANDIDA-ALBICANS YEAST, SACCHAROMYCES-CEREVISIAE, IMMUNE-SYSTEM, NADPH OXIDASE, HOST-DEFENSE, HYPHAL FORMS, TH17 CELLS, RECEPTOR, biology.protein, Infection and autoimmunity [NCMLS 1]
Abstract

Contains fulltext : 88878.pdf (Publisher’s version ) (Closed access) In this study, we present evidence of differential Th17 responses in human monocyte-derived dendritic cells exposed to the pathogenic Candida albicans or the nonpathogenic Saccharomyces cerevisiae. We use different forms of the microorganisms, cells, hyphae, and spores, as a toolbox to dissect the role of surface mannan in the fungal immune response. In contrast to the S. cerevisiae yeast cell-induced Th1 response, dendritic cells stimulated with spores or C. albicans hyphae induce cellular responses shifted toward Th17 differentiation. The differential recognition of specific mannan structures is the master regulator of the discrimination between harmful and harmless fungi. The switch between spores and yeast is crucial for the commensalism of S. cerevisiae and depends on the use of a different receptor repertoire. Understanding the role of cell wall recognition during infection might lead to understanding the boundaries between safety and pathogenicity.

Published
2010

2. Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection

Author

Edina Schweighoffer, Gordon D. Brown, Caetano Reis e Sousa, Luis F. Moita, Fabiola Osorio, J. Sjef Verbeek, Victor L. J. Tybulewicz, Marcela Rosas, Matthew J. Robinson, Olaf Groß, Jürgen Ruland, Philip R. Taylor, and Rui P. Freitas

Subjects
NF-KAPPA-B, Syk, CANDIDA-ALBICANS YEAST, Research & Experimental Medicine, Mice, 0302 clinical medicine, Aldesleukin, Immunology and Allergy, Mice, Knockout, 0303 health sciences, Reverse Transcriptase Polymerase Chain Reaction, Interleukin-17, Pattern recognition receptor, Candidiasis, Intracellular Signaling Peptides and Proteins, T-Lymphocytes, Helper-Inducer, 11 Medical And Health Sciences, Protein-Tyrosine Kinases, Flow Cytometry, 3. Good health, Cell biology, medicine.anatomical_structure, Medicine, Research & Experimental, Receptors, Pattern Recognition, QR180, Signal transduction, Life Sciences & Biomedicine, Signal Transduction, T cell, Immunology, Immunoblotting, chemical and pharmacologic phenomena, Biology, DENDRITIC CELLS, Article, C-TYPE LECTIN, 03 medical and health sciences, Immune system, HOST-DEFENSE, ANTIFUNGAL IMMUNITY, medicine, Animals, Syk Kinase, Lectins, C-Type, 030304 developmental biology, Adaptor Proteins, Signal Transducing, TOLL-LIKE RECEPTORS, Innate immune system, Science & Technology, T-CELL RESPONSES, ACTIVATING RECEPTOR, Cell Biology, Dendritic cell, CARD Signaling Adaptor Proteins, Mice, Inbred C57BL, Adaptor Proteins, Vesicular Transport, Myeloid Differentiation Factor 88, INNATE IMMUNITY, 030215 immunology
Abstract

Innate immune cells detect pathogens via pattern recognition receptors (PRRs), which signal for initiation of immune responses to infection. Studies with Dectin-1, a PRR for fungi, have defined a novel innate signaling pathway involving Syk kinase and the adaptor CARD9, which is critical for inducing Th17 responses to fungal infection. We show that another C-type lectin, Dectin-2, also signals via Syk and CARD9, and contributes to dendritic cell (DC) activation by fungal particles. Unlike Dectin-1, Dectin-2 couples to Syk indirectly, through association with the FcRγ chain. In a model of Candida albicans infection, blockade of Dectin-2 did not affect innate immune resistance but abrogated Candida-specific T cell production of IL-17 and, in combination with the absence of Dectin-1, decreased Th1 responses to the organism. Thus, Dectin-2 constitutes a major fungal PRR that can couple to the Syk–CARD9 innate signaling pathway to activate DCs and regulate adaptive immune responses to fungal infection.

Published
2009

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