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417 results on '"CAETANO, A. R."'

3. Orbital selectivity versus Pomeranchuk instability in the iron-chalcogenide superconductors: A two-loop renormalization group study

Author

Caetano, Rafael R. and Freire, Hermann

Subjects
Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Superconductivity
Abstract

We perform a two-loop renormalization group (RG) analysis of a 2D effective multiband model, which is relevant for describing the low-energy properties of some iron-chalcogenide superconducting materials. Crucial ingredients in this analysis are the calculation of higher-order contributions in the RG scheme that go beyond the widely-used parquet approximation and the consequent inclusion of nontrivial self-energy effects of the model that yield an anisotropic renormalization of the quasiparticle weight in the system. The motivation of our work is the experimental discovery by Sprau et al. (2017) that orbitally-selective renormalization of the quasiparticle weight in the Hund's metal phase at moderate temperatures underpins the highly unusual gap in the superconducting phase of the FeSe compound at lower temperatures. One prediction we arrive here is that the underlying origin of nematicity in these systems may indeed come from orbital-selectivity, instead of a Pomeranchuk instability in the $d_{\pm}$ channel. This orbital selectivity is driven by the presence of stripe-type antiferromagnetic fluctuations in the model. Therefore, we argue that the present RG results may provide a scenario from a weak-to-moderate coupling perspective, in which the role of orbital selectivity to describe the physical properties of some iron-chalcogenide superconductors is emphasized., Comment: 14 pages, 9 figures

Published
2018
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8. Prognostic Factors After Hepatectomy for Gastric Adenocarcinoma Liver Metastases: Desmoplastic Growth Pattern as the Key to Improved Overall Survival

Author

Temido MJ, Caetano Oliveira R, Martins R, Serôdio M, Costa B, Carvalho C, Santos E, Ferreira L, Teixeira P, Cipriano MA, Tralhão JG, and Alexandrino H

Subjects
liver metastases, gastric carcinoma, hepatectomy, growth pattern, prognosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Maria José Temido,1,2,* Rui Caetano Oliveira,3– 6,* Ricardo Martins,2,4,5,7 Marco Serôdio,2,7 Beatriz Costa,2,5,7 César Carvalho,7 Eva Santos,2,7 Luís Ferreira,7 Paulo Teixeira,3,8 Maria Augusta Cipriano,3 José Guilherme Tralhão,2,4,5,7 Henrique Alexandrino2,5,7 1Gastroenterology Department, Centro Hospitalar e Universitário de Coimbra, Coimbra 3000-075, Portugal; 2Faculty of Medicine, University of Coimbra, Coimbra 3000-548, Portugal; 3Pathology Department, Centro Hospitalar e Universitário de Coimbra, Coimbra 3000-075, Portugal; 4Biophysics Institute, Faculty of Medicine, University of Coimbra, Coimbra 3000-548, Portugal; 5Coimbra Institute for Clinical and Biomedical Research (iCBR), Area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, Coimbra 3000-548, Portugal; 6Faculdade de Medicina da Universidade do Porto, Porto 4200-319, Portugal; 7Department of Surgery, Centro Hospitalar e Universitário de Coimbra, Coimbra 3000-075, Portugal; 8Department Biomedical Laboratory Sciences, ESTeSC- Coimbra Health School, Polytechnic Institute of Coimbra, Coimbra 3046-854, Portugal*These authors contributed equally to this workCorrespondence: Maria José TemidoCentro Hospitalar e Universitário de Coimbra, Praceta Professor Mota Pinto, Coimbra 3004-561, PortugalTel +351 910772166Email mariajosetemido@gmail.comPurpose: Hepatectomy (Hp) is an alternative approach for the treatment of gastric carcinoma liver metastases (GCLM). However, prognostic factors that may assist patient selection are still controversial. Several pathologic features, such as the growth pattern (GP), associated with prognosis in colorectal cancer liver metastases, were never investigated in GCLM. Our principal aim was to assess if the GP has prognostic impact on GCLM.Patients and Methods: Review of the clinical and pathological characteristics of 19 consecutive patients submitted to surgical resection of GCLM with curative intent at our department. Major potential prognostic factors considered were patients’ gender, age, timing and extent of Hp, postoperative course, as well as histopathological characteristics of primary and secondary tumors.Results: Major morbidity occurred in four patients, mortality in one. Median and 5-year overall survival were 17 months and 26.7%, respectively. Ten patients developed recurrent disease and two patients survived more than 10 years. Factors independently associated with overall survival were the absence of major morbidity, distal location of the primary tumor, and desmoplastic GP (p< 0.05).Conclusion: The selection of patients is crucial for the improvement of survival rates of GCLM. Consequently, we demonstrate for the first time that the desmoplastic GP of GCLM is associated with improved outcomes, prompting further research on tumor–host interactions.Keywords: liver metastases, gastric carcinoma, hepatectomy, growth pattern, prognosis

Published
2020

9. Chemical Wet Oxidation of Carbon Nanotubes for Electrochemical Determination of Methyl Parathion

Author

Michelle C. Oliveira, Caetano, Fábio R., Papi, Mauricio A. P., Watanabe, Emily Y., Marcolino-Júnior, Luiz H., and Bergamini, Márcio F.

Subjects
Infrared spectroscopy -- Electric properties -- Political aspects, Sensors -- Electric properties -- Political aspects, Hydroxides -- Electric properties -- Political aspects, Nanotubes -- Electric properties -- Political aspects, Oxidation-reduction reaction -- Electric properties -- Political aspects, Chemistry
Abstract

Surface properties of carbon nanotubes in electrochemical sensors can be dramatically altered depending on chemical groups and structural defects present on the surface. The effect of oxidation on structural integrity of multiwalled carbon nanotubes through acidic (nitric/sulfuric acids) and basic (sodium hydroxide) agents has been studied. Chemical modifications of carbon nanotubes structures were evaluated by Raman, Fourier transform infrared spectroscopy and transmission electronic microscopy. Furthermore, these materials were used to construct sensors for electrochemical determination of pesticide methyl parathion (MP). Under optimized conditions, a calibration curve was obtained for MP determination employing a glassy carbon electrode modified with acidic treated and basic treated carbon nanotubes which showed a linear response ranging from 1.0 x 10.sup.-7 to 3.4 x 10.sup.-5 M with limits of detection of 3.3 x 10.sup.-8 and 3.5 x10.sup.-8 M, respectively. Analytical performance of the electrodes showed similar voltammetric behavior providing good sensitivity for the determination of methyl parathion., Author(s): Michelle C. Oliveira [sup.1] [sup.2], Fábio R. Caetano [sup.1] [sup.2], Mauricio A. P. Papi [sup.1] [sup.2], Emily Y. Watanabe [sup.1] [sup.2], Luiz H. Marcolino-Júnior [sup.1] [sup.2], Márcio F. Bergamini [...]

Published
2020
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13. The Brazilian Soil Spectral Library (BSSL): A general view, application and challenges

Author

Demattê, José A.M., Dotto, André Carnieletto, Paiva, Ariane F.S., Sato, Marcus V., Dalmolin, Ricardo S.D., de Araújo, Maria do Socorro B., da Silva, Elisângela B., Nanni, Marcos R., ten Caten, Alexandre, Noronha, Norberto C., Lacerda, Marilusa P.C., de Araújo Filho, José Coelho, Rizzo, Rodnei, Bellinaso, Henrique, Francelino, Márcio R., Schaefer, Carlos E.G.R., Vicente, Luiz E., dos Santos, Uemeson J., de Sá Barretto Sampaio, Everardo V., Menezes, Rômulo S.C., de Souza, José João L.L., Abrahão, Walter A.P., Coelho, Ricardo M., Grego, Célia R., Lani, João L., Fernandes, Antonio R., Gonçalves, Deyvison A.M., Silva, Sérgio H.G., de Menezes, Michele D., Curi, Nilton, Couto, Eduardo G., dos Anjos, Lúcia H.C., Ceddia, Marcos B., Pinheiro, Érika F.M., Grunwald, Sabine, Vasques, Gustavo M., Marques Júnior, José, da Silva, Airon J., Barreto, Marcos C. de Vasconcelos, Nóbrega, Gabriel N., da Silva, Marcelo Z., de Souza, Sara F., Valladares, Gustavo S., Viana, João Herbert M., da Silva Terra, Fabricio, Horák-Terra, Ingrid, Fiorio, Peterson R., da Silva, Rafael C., Frade Júnior, Elizio F., Lima, Raimundo H.C., Alba, José M. Filippini, de Souza Junior, Valdomiro S., Brefin, Maria De Lourdes Mendonça Santos, Ruivo, Maria De Lourdes P., Ferreira, Tiago O., Brait, Marny A., Caetano, Norton R., Bringhenti, Idone, de Sousa Mendes, Wanderson, Safanelli, José L., Guimarães, Clécia C.B., Poppiel, Raul R., e Souza, Arnaldo Barros, Quesada, Carlos A., and do Couto, Hilton T. Zarate

Published
2019
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18. The co-evolution of societal issues, technologies and industry regimes : three case studies of the American automobile industry

Author

Penna, Caetano C. R.

Subjects
338.4, HD2350.8 Large industry. Factory system. Big business, TL0001 Motor vehicles.Cycles
Abstract

This thesis contributes to closing a gap in the field of science, technology and innovation (STI) policy research: despite many theoretical advances in the field, we still do not know why some urgent societal issues (or ‘challenges') remain unaddressed, notwithstanding the technological advances that could potentially address them. In particular, radical technological innovations – innovations that depart from the established technological trajectory – would offer greatest potential to address societal challenges. While the source of radical innovations is often new entrepreneurial firms, established firms (‘incumbents') are likely to play an important role in developing them because of the vast resources and complementary assets they possess. Incumbents however, face few immediate incentives to develop radical innovations in response to societal challenges. The analytical puzzle of this thesis is thus to explain how, when, and why industries change (or not) their strategies (in particular, their technological strategy) in order to address a societal problem. This puzzle is disentangled into interrelated research questions: A) How do societal issue­‐related pressures (on the incumbent industry) from different domains (namely, civil society, science, political arena, economy) evolve? B) How does the incumbent industry respond to changing pressures around societal issues, in terms of technological, political, cultural and economic strategies? C) In particular, when and why do industry actors decide to develop substantive technological responses? To answer these questions, the thesis develops a new analytical perspective that combines insights from (a) issue life­‐cycle and issue attention cycle theories (from the Business & Society field) with (b) the so­‐called ‘Triple Embeddedness Framework' and (c) concepts from business strategies, innovation management, corporate political strategies, and technology policy. This novel perspective represents an ideal­‐typical model of issue evolution (‘issue life ­‐cycle'). The model, which I call the Dialectic Issue Life­‐Cycle (DILC) model, is applied to three case studies of the American automobile industry's responses to various societal problems (local air pollution, auto and highway safety, and climate change). Combining qualitative and quantitative research methods in an original way, the case studies aim not only to investigate the validity of the framework, which also provides conceptual answers to the research questions, but also to further refine it and nuance the conceptual answers. By explaining how incumbent industry actors respond to societal challenges, this thesis ultimately contributes to the practical policy debate of how incumbents can be stimulated to develop radical innovations that help address societal challenges.

Published
2014

26. Cumulus‐oocyte complexes from sows show differences in lipid metabolism compared to cumulus‐oocyte complexes from prepubertal gilts during in vitro maturation

Author

Silva, Thainara C. F., primary, Dode, Margot A. N., additional, Braga, Thiago F., additional, Marques, Mariana G., additional, Vargas, Luna Nascimento, additional, de Faria, Otávio Augusto Costa, additional, de Souza, Andressa P., additional, Albring, Daniela, additional, Caetano, Alexandre R., additional, and Franco, Maurício M., additional

Published
2023
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28. Transformative investment: New rules for investing in sustainability transitions

Author

Penna, Caetano C. R., Schot, Johan, Steinmueller, W. . Edward, Penna, Caetano C. R., Schot, Johan, and Steinmueller, W. . Edward

Abstract

Closing the financial gap for promoting systemic socio-economic transformations to achieve sustainability requires both a substantial increase in investment levels and a qualitative change in investment strategies. In this Perspective, we elaborate on this claim and discuss why existing investment approaches that aim to make positive contributions to sustainability are unlikely to foster the systemic transformations needed for sustainability. Qualitative change means changing the current rules that guide investment practices and we outline a new set of rules that should guide transformative investment. These rules are based on the well-established socio-technical sustainability transition theory and the recent development of a theory of deep transitions. We explain why these transformative investment rules offer a promising alternative base for assessing investment opportunities and monitoring progress toward the multi-system changes required to achieve a socially just deep transition to sustainability.

Published
2023

40. O Papel das Agências de Inovação e Empreendedorismo na Formulação de Políticas de Inovação Orientadas a Missões

Author

Maurício de Vasconcellos Guedes Pereira, Caetano C. R. Penna, and Guilherme de Oliveira Santos Santos

Subjects
Sustainable development, Strategic planning, Policy making, Constitution, Welfare economics, media_common.quotation_subject, Political science, General Medicine, media_common
Abstract

O presente artigo tem como principal objetivo discutir as oportunidades e desafios para o desenvolvimento de uma política de inovação orientada a missões baseada nos Objetivos do Desenvolvimento Sustentável (ODS), tendo como foco a experiência recente da Diretoria de Tecnologia da Fundação Carlos Chagas de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ). Para tanto, será feita uma revisão bibliográfica acerca do papel das agências de inovação e das políticas de inovação orientadas a missões. A parte empírica do artigo será baseada em uma pesquisa documental, bem como no Planejamento Estratégico feito para a Diretoria da Tecnologia para o triênio 2019-2021. As principais conclusões apontam que: (a) o Estado do Rio de Janeiro possui desafios socioeconômicos possíveis de embasarem uma estratégia de inovação voltada para a solução de problemas; (b) a fragmentação do cenário institucional do estado se coloca não apenas como um desafio para a elaboração de políticas de inovação orientadas a missões, mas também como oportunidade; (c) a complexidade dos desafios societais porém dificulta a formulação e implantação destas políticas; e (d) a construção de indicadores e métricas para mensurar o impacto de tais políticas é bastante desafiadora.

Published
2021
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42. Supplementary Material for Whole-genome resequencing of worldwide wild and domestic sheep elucidates genetic diversity, introgression and agronomically important loci

Author

Li, Meng-Hua [menghua.li@cau.edu.cn], Lv, Feng-Hua, Cao, Yin-Hong, Liu, Guang-Jian, Luo, Ling-Yun, Lu, Ran, Liu, Ming-Jun, Li, Wen-Rong, Zhou, Ping, Wang, Xin-Hua, Shen, Min, Gao, Lei, Yang, Jing-Quan, Yang, Hua, Yang, Yong-Lin, Liu, Chang-Bin, Wan, Peng-Cheng, Zhang, Yun-Sheng, Pi, Wen-Hui, Ren, Yan-Ling, Shen, Zhi-Qiang, Wang, Feng, Wang, Yu-Tao, Li, Jin-Quan, Salehian-Dehkordi, Hosein, Hehua, Eer, Liu, Yong-Gang, Chen, Jian-Fei, Wang, Jian-Kui, Deng, Xue-Mei, Esmailizadeh, Ali, Dehghani-Qanatqestani, Mostafa, Charati, Hadi, Nosrati, Maryam, Štěpánek, Ondřej, Rushdi, Hossam E., Olsaker, Ingrid, Curik, Ino, Gorkhali, Neena A., Paiva, S. R., Caetano, Alexander R., Ciani, Elena, Amills, Marcel, Weimann, Christina, Erhardt, Georg, Amane, Agraw, Mwacharo, Joram M., Han, Jian-Lin, Hanotte, Olivier, Periasamy, Kathiravan, Johansson, Anna M., Hallsson, Jón H., Kantanen, Juha, Coltman, David W., Bruford, Michael W., Lenstra, Johannes A., Li, Meng-Hua, Li, Meng-Hua [menghua.li@cau.edu.cn], Lv, Feng-Hua, Cao, Yin-Hong, Liu, Guang-Jian, Luo, Ling-Yun, Lu, Ran, Liu, Ming-Jun, Li, Wen-Rong, Zhou, Ping, Wang, Xin-Hua, Shen, Min, Gao, Lei, Yang, Jing-Quan, Yang, Hua, Yang, Yong-Lin, Liu, Chang-Bin, Wan, Peng-Cheng, Zhang, Yun-Sheng, Pi, Wen-Hui, Ren, Yan-Ling, Shen, Zhi-Qiang, Wang, Feng, Wang, Yu-Tao, Li, Jin-Quan, Salehian-Dehkordi, Hosein, Hehua, Eer, Liu, Yong-Gang, Chen, Jian-Fei, Wang, Jian-Kui, Deng, Xue-Mei, Esmailizadeh, Ali, Dehghani-Qanatqestani, Mostafa, Charati, Hadi, Nosrati, Maryam, Štěpánek, Ondřej, Rushdi, Hossam E., Olsaker, Ingrid, Curik, Ino, Gorkhali, Neena A., Paiva, S. R., Caetano, Alexander R., Ciani, Elena, Amills, Marcel, Weimann, Christina, Erhardt, Georg, Amane, Agraw, Mwacharo, Joram M., Han, Jian-Lin, Hanotte, Olivier, Periasamy, Kathiravan, Johansson, Anna M., Hallsson, Jón H., Kantanen, Juha, Coltman, David W., Bruford, Michael W., Lenstra, Johannes A., and Li, Meng-Hua

Published
2022

43. Whole-genome resequencing of worldwide wild and domestic sheep elucidates genetic diversity, introgression, and agronomically important loci

Author

National Natural Science Foundation of China, National Key Research and Development Program (China), Chinese Academy of Sciences, Lv, Feng-Hua, Cao, Yin-Hong, Liu, Guang-Jian, Luo, Ling-Yun, Lu, Ran, Liu, Ming-Jun, Li, Wen-Rong, Zhou, Ping, Wang, Xin-Hua, Shen, Min, Gao, Lei, Yang, Jing-Quan, Yang, Hua, Yang, Yong-Lin, Liu, Chang-Bin, Wan, Peng-Cheng, Zhang, Yun-Sheng, Pi, Wen-Hui, Ren, Yan-Ling, Shen, Zhi-Qiang, Wang, Feng, Wang, Yu-Tao, Li, Jin-Quan, Salehian-Dehkordi, Hosein, Hehua, Eer, Liu, Yong-Gang, Chen, Jian-Fei, Wang, Jian-Kui, Deng, Xue-Mei, Esmailizadeh, Ali, Dehghani-Qanatqestani, Mostafa, Charati, Hadi, Nosrati, Maryam, Štěpánek, Ondřej, Rushdi, Hossam E., Olsaker, Ingrid, Curik, Ino, Gorkhali, Neena A., Paiva, S. R., Caetano, Alexander R., Ciani, Elena, Amills, Marcel, Weimann, Christina, Erhardt, Georg, Amane, Agraw, Mwacharo, Joram M., Han, Jian-Lin, Hanotte, Olivier, Periasamy, Kathiravan, Johansson, Anna M., Hallsson, Jón H., Kantanen, Juha, Coltman, David W., Bruford, Michael W., Lenstra, Johannes A., Li, Meng-Hua, National Natural Science Foundation of China, National Key Research and Development Program (China), Chinese Academy of Sciences, Lv, Feng-Hua, Cao, Yin-Hong, Liu, Guang-Jian, Luo, Ling-Yun, Lu, Ran, Liu, Ming-Jun, Li, Wen-Rong, Zhou, Ping, Wang, Xin-Hua, Shen, Min, Gao, Lei, Yang, Jing-Quan, Yang, Hua, Yang, Yong-Lin, Liu, Chang-Bin, Wan, Peng-Cheng, Zhang, Yun-Sheng, Pi, Wen-Hui, Ren, Yan-Ling, Shen, Zhi-Qiang, Wang, Feng, Wang, Yu-Tao, Li, Jin-Quan, Salehian-Dehkordi, Hosein, Hehua, Eer, Liu, Yong-Gang, Chen, Jian-Fei, Wang, Jian-Kui, Deng, Xue-Mei, Esmailizadeh, Ali, Dehghani-Qanatqestani, Mostafa, Charati, Hadi, Nosrati, Maryam, Štěpánek, Ondřej, Rushdi, Hossam E., Olsaker, Ingrid, Curik, Ino, Gorkhali, Neena A., Paiva, S. R., Caetano, Alexander R., Ciani, Elena, Amills, Marcel, Weimann, Christina, Erhardt, Georg, Amane, Agraw, Mwacharo, Joram M., Han, Jian-Lin, Hanotte, Olivier, Periasamy, Kathiravan, Johansson, Anna M., Hallsson, Jón H., Kantanen, Juha, Coltman, David W., Bruford, Michael W., Lenstra, Johannes A., and Li, Meng-Hua

Abstract

Domestic sheep and their wild relatives harbor substantial genetic variants that can form the backbone of molecular breeding, but their genome landscapes remain understudied. Here, we present a comprehensive genome resource for wild ovine species, landraces and improved breeds of domestic sheep, comprising high-coverage (∼16.10×) whole genomes of 810 samples from 7 wild species and 158 diverse domestic populations. We detected, in total, ∼121.2 million single nucleotide polymorphisms, ∼61 million of which are novel. Some display significant (P < 0.001) differences in frequency between wild and domestic species, or are private to continent-wide or individual sheep populations. Retained or introgressed wild gene variants in domestic populations have contributed to local adaptation, such as the variation in the HBB associated with plateau adaptation. We identified novel and previously reported targets of selection on morphological and agronomic traits such as stature, horn, tail configuration, and wool fineness. We explored the genetic basis of wool fineness and unveiled a novel mutation (chr25: T7,068,586C) in the 3′-UTR of IRF2BP2 as plausible causal variant for fleece fiber diameter. We reconstructed prehistorical migrations from the Near Eastern domestication center to South-and-Southeast Asia and found two main waves of migrations across the Eurasian Steppe and the Iranian Plateau in the Early and Late Bronze Ages. Our findings refine our understanding of genome variation as shaped by continental migrations, introgression, adaptation, and selection of sheep.

Published
2022

46. Evolutionary pressures rendered by animal husbandry practices for avian influenza viruses to adapt to humans

Author

CAMARGO, M. M. de, CAETANO, A. R., SANTOS, I. K. F. de M., MARISTELA MARTINS DE CAMARGO, USP, ALEXANDRE RODRIGUES CAETANO, Cenargen, and ISABEL KINNEY FERREIRA DE MIRANDA SANTOS, USP.

Subjects
Animal protein, Avian influenza viruses
Abstract

Made available in DSpace on 2022-06-12T04:02:17Z (GMT). No. of bitstreams: 1 1-s2.0-S2589004222002759-main.pdf: 2150077 bytes, checksum: d74502087b8300edb988ead06dd1ac28 (MD5) Previous issue date: 2022

Published
2022

47. Whole-Genome Resequencing of Worldwide Wild and Domestic Sheep Elucidates Genetic Diversity, Introgression, and Agronomically Important Loci

Author

Lv, Feng-Hua, Cao, Yin-Hong, Liu, Guang-Jian, Luo, Ling-Yun, Lu, Ran, Liu, Ming-Jun, Li, Wen-Rong, Zhou, Ping, Wang, Xin-Hua, Shen, Min, Gao, Lei, Yang, Jing-Quan, Yang, Hua, Yang, Yong-Lin, Liu, Chang-Bin, Wan, Peng-Cheng, Zhang, Yun-Sheng, Pi, Wen-Hui, Ren, Yan-Ling, Shen, Zhi-Qiang, Wang, Feng, Li, Jin-Quan, Salehian-Dehkordi, Hosein, Hehua, Eer, Liu, Yong-Gang, Chen, Jian-Fei, Wang, Jian-Kui, Deng, Xue-Mei, Esmailizadeh, Ali, Dehghani-Qanatqestani, Mostafa, Charati, Hadi, Nosrati, Maryam, Stepanek, Ondrej, Rushdi, Hossam E., Olsaker, Ingrid, Curik, Ino, Gorkhali, Neena A., Paiva, Samuel R., Caetano, Alexandre R., Ciani, Elena, Amills, Marcel, Weimann, Christina, Erhardt, Georg, Amane, Agraw, Mwacharo, Joram M., Han, Jian-Lin, Hanotte, Olivier, Periasamy, Kathiravan, Johansson, Anna Maria, Hallsson, Jon H., Kantanen, Juha, Coltman, David W., Bruford, Michael W., Lenstra, Johannes A., and Li, Meng-Hua

Subjects
Evolutionary Biology
Abstract

Domestic sheep and their wild relatives harbor substantial genetic variants that can form the backbone of molecular breeding, but their genome landscapes remain understudied. Here, we present a comprehensive genome resource for wild ovine species, landraces and improved breeds of domestic sheep, comprising high-coverage (similar to 16.10x) whole genomes of 810 samples from 7 wild species and 158 diverse domestic populations. We detected, in total, similar to 121.2 million single nucleotide polymorphisms, similar to 61 million of which are novel. Some display significant (P < 0.001) differences in frequency between wild and domestic species, or are private to continent-wide or individual sheep populations. Retained or introgressed wild gene variants in domestic populations have contributed to local adaptation, such as the variation in the HBB associated with plateau adaptation. We identified novel and previously reported targets of selection on morphological and agronomic traits such as stature, horn, tail configuration, and wool fineness. We explored the genetic basis of wool fineness and unveiled a novel mutation (chr25: T7,068,586C) in the 3 '-UTR of IRF2BP2 as plausible causal variant for fleece fiber diameter. We reconstructed prehistorical migrations from the Near Eastern domestication center to South-and-Southeast Asia and found two main waves of migrations across the Eurasian Steppe and the Iranian Plateau in the Early and Late Bronze Ages. Our findings refine our understanding of genome variation as shaped by continental migrations, introgression, adaptation, and selection of sheep.

Published
2022

48. Resolving the Evolution of Extant and Extinct Ruminants with High-Throughput Phylogenomics

Author

Decker, Jared E., Pires, J. Chris, Conant, Gavin C., McKay, Stephanie D., Heaton, Michael P., Chen, Kefei, Cooper, Alan, Vilkki, Johanna, Seabury, Christopher M., Caetano, Alexandre R., Johnson, Gary S., Brenneman, Rick A., Hanotte, Olivier, Eggert, Lori S., Wiener, Pamela, Kim, Jong-Joo, Kim, Kwan Suk, Sonstegard, Tad S., Van Tassell, Curt P., Neibergs, Holly L., McEwan, John C., Brauning, Rudiger, Coutinho, Luiz L., Babar, Masroor E., Wilson, Gregory A., McClure, Matthew C., Rolf, Megan M., Kim, JaeWoo, Schnabel, Robert D., and Taylor, Jeremy F.

Published
2009
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50. Polycyclic aromatic hydrocarbons in cachaças packed in bottles of polyethylene terephthalate

Author

Souza, Rafaella H. Z., primary, Cardoso, Maria das Graças, additional, Machado, Ana Maria R., additional, Santiago, Wilder D., additional, Pedroso, Márcio P., additional, Brandão, Rafaela M., additional, Oliveira, Renan E. S., additional, Barbosa, Richard B., additional, Alvarenga, Gabriela F., additional, Caetano, Alex R. S., additional, and Nelson, David L., additional

Published
2022
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