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2 results on '"CAD extent"'

1. Prevalence of atrial fibrillation dependent on coronary artery status: Insights from the LIFE‐Heart Study

Author

Kornej, Jelena, Henger, Sylvia, Seewöster, Timm, Teren, Andrej, Burkhardt, Ralph, Thiele, Holger, Thiery, Joachim, and Scholz, Markus

Subjects
Male, Cardiac Catheterization, CAD origin, prevalence, Clinical Investigations, coronary artery sclerosis, Coronary Artery Disease, Middle Aged, Coronary Angiography, Coronary Vessels, Electrocardiography, Risk Factors, Germany, Atrial Fibrillation, Humans, Female, cardiovascular diseases, CAD extent, Aged, Retrospective Studies
Abstract

Background Coronary artery disease (CAD) is a significant risk factor for atrial fibrillation (AF). Experimental studies demonstrated that atrial ischemia induced by right coronary artery (RCA) stenosis promote AF triggers and development of electro‐anatomical substrate for AF. Aim To analyze the association between AF prevalence and coronary arteries status in the LIFE‐Heart Study. Methods This analysis included patients with available coronary catheterization data recruited between 2006 and 2014. Patients with acute myocardial infarction were excluded. CAD was defined as stenosis ≥75%, while coronary artery sclerosis (CAS) was defined as non‐critical plaque(s)

Published
2020

2. Association of plasma cholesteryl ester transfer protein activity and polymorphism with coronary artery disease extent in Tunisian type II diabetic patients

Author

Chaaba, R., Hammami, S., Attia, N., Smaoui, M., Masmoudi, A.S., Mahjoub, S., Ben Hamda, K., and Hammami, M.

Subjects
*CHOLESTEROL, *ISOPENTENOIDS, *PEOPLE with diabetes, *ESTERS
Abstract

Abstract: Introduction:: Cholesteryl ester transfer protein (CETP), a key protein in reverse cholesterol transport, has a controversial role in atherosclerosis. Objectives:: We investigated CETP activity and polymorphism in Tunisian type II diabetes and its relationship with coronary artery disease (CAD). Design and methods:: 173 type II diabetic patients with or without CAD were compared to 67 controls. Results:: The HDL cholesterol concentration was low in a Tunisian population. The B1 allele of the CETP gene was associated with a low concentration of HDL cholesterol and was more frequent in Tunisians than in other populations. In type II diabetic patients, the B1 allele was associated with increased prevalence of CAD only in men (OR = 0.357, CI = 0.161–0.791, P = 0.01). The CETP activity increased in type II diabetic patients compared to controls (P = 0.05). Furthermore, the CETP activity was increased in patients with double or triple vessel disease compared to those with single vessel disease (P = 0.025). Conclusions:: Our data are in favour of an association between CETP and developing CAD, as well as the extent of CAD. [Copyright &y& Elsevier]

Published
2005
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