1. High cognitive reserve in bipolar disorders as a moderator of neurocognitive impairment
- Author
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Anabel Martínez-Arán, Eduard Vieta, Ivette Morilla, Iria Grande, José Luis Ayuso-Mateos, Esther Jiménez, Rafael Tabarés-Seisdedos, C. Varo, Brisa Solé, Carla Torrent, Vicent Balanzá-Martínez, C.M. Bonnin, E. Valls, Andre F. Carvalho, and José Sánchez-Moreno
- Subjects
Adult ,Male ,medicine.medical_specialty ,Elementary cognitive task ,Bipolar Disorder ,Bipolar disorder ,Cognitive reserve ,Neuropsychological Tests ,Audiology ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Cognitive Reserve ,medicine ,Humans ,Verbal fluency test ,Cognitive skill ,Psychiatry ,Neurocognition ,California Verbal Learning Test ,Bipolar disorder, Cognitive heterogeneity, Cognitive reserve, Neurocognition ,Middle Aged ,medicine.disease ,Cyclothymic Disorder ,030227 psychiatry ,Diagnostic and Statistical Manual of Mental Disorders ,Psychiatry and Mental health ,Clinical Psychology ,Cross-Sectional Studies ,Cognitive remediation therapy ,Female ,Cues ,Verbal memory ,Cognition Disorders ,Psychology ,Neurocognitive ,030217 neurology & neurosurgery ,Cognitive heterogeneity - Abstract
BackgroundCognitive reserve (CR) reflects the capacity of the brain to endure neuropathology, minimize clinical manifestations and successfully complete cognitive tasks. The present study aims to determine whether high CR may constitute a moderator of cognitive functioning in bipolar disorder (BD).MethodsOne hundred and two patients with BD and 32 healthy controls were enrolled. All patients met DSM-IV criteria for I or II BD and were euthymic (YMRS ≤ 6 and HDRS ≤ 8) during a 6-month period. All participants were tested with a comprehensive neuropsychological battery, and a Cerebral Reserve Score (CRS) was estimated. Subjects with a CRS below the group median were classified as having low CR, whereas participants with a CRS above the median value were considered to have high CR.ResultsParticipants with BD with high CR displayed a better performance in measures of attention (digits forward: F = 4.554, P = 0.039); phonemic and semantic verbal fluency (FAS: F = 9.328, P = 0.004; and Animal Naming: F = 8.532, P = 0.006); and verbal memory (short cued recall of California Verbal Learning Test: F = 4.236, P = 0.046), after multivariable adjustment for potential confounders, including number of admissions and prior psychotic symptoms.ConclusionsHigh cognitive reserve may therefore be a valuable construct to explore for predicting neurocognitive performance in patients with BD regarding premorbid status.Disclosure of interestDr. I. Grande has received a Juan Rodés Contract (JR15/00012), Instituto de Salud Carlos III, Spanish Ministry of Economy and Competiveness, Barcelona, Spain and has served as a consultant for Ferrer and as a speaker for AstraZeneca, Ferrer and Janssen-Cilag.Disclosure of interestDr. I. Grande has received a Juan Rodés Contract (JR15/00012), Instituto de Salud Carlos III, Spanish Ministry of Economy and Competiveness, Barcelona, Spain and has served as a consultant for Ferrer and as a speaker for AstraZeneca, Ferrer and Janssen-Cilag.
- Published
- 2017