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The partial or complete excision of the hemipelvis with the sparing of the lower limb is an option of the treatment of pelvic chondrosarcomas and a therapeutic alternative of the interilio-abdominal disarticulation. The operation has the same indications as the interilio-abdominal disarticulation and offers a good solution for avoiding a mutilating operation. A giant periacetabular pelvic chondrosarcoma developed in Ennequin zone II and partial zone III, was resected and reconstructed with iliofemoral cooptation after complex investigations - pelvic X-ray, CT, MRI, Bioptic confirmation. The wide excision of the tumor, a stable reconstruction, and an efficient recovery are essential for a successful treatment of pelvic chondrosarcomas.

Summary. Background: Chronic venous insufficiency (CVI) results when the veins in the legs no longer pump blood back to the heart effectively. Microparticles (MPs) are small membrane vesicles released by several circulating and vascular cells upon activation or apoptosis. Objectives: The purpose of this study was to assess the subpopulations of circulating endothelial (EMPs) and platelet microparticles (PMPs) in CVI, and to disclose their contribution in mediating dysfunction of human peripheral venules. Patients and methods: Human peripheral venules were explanted during leg surgery on patients with CVI and on control subjects (C); concurrently, blood samples were collected and circulating MPs isolated. The techniques used were: flow cytometry, fluorescence and electron microscopy, myograph technique and western-blotting technique. Results: The results showed that compared with controls, patients with CVI had: (i) a marked elevation of circulating EMPs and PMPs; (ii) a structural modification of the venous wall consisting of activation of endothelial and smooth muscle cells, an abundance of intermediary filaments and synthesis of hyperplasic-multilayered basal lamina; (iii) a significantly altered reactivity of the venous wall, closely associated with EMPs and PMPs adherence; (iv) altered contractile response to noradrenaline, acetylcholine, 5-hydroxytryptamine and KCl, and an impeded relaxation in response to sodium nitroprusside; and (iv) a substantially increased protein expression of tissue factor (TF) and of P-Selectin both in the venular vascular wall and on the surface of EMPs and PMPs. Conclusions: The findings indicate that CVI is accompanied by an enhanced release of EMPs and PMPs that contribute to altered dysfunctional response of the venous wall.

Towns and cities across the European Union are facing the most challenging economic climate in living memory. Against this backdrop, sustainable development and environmental stewardship are concepts that may appear now as more of a luxury than a strategic priority at a time of drastic cost-cutting in local authority resources across many European countries. Increasingly, the long term importance of investing in sustainability practices such as energy and waste reductions needs to be justified in the short term by a sound business case. In other words, saving the planet needs to be shown to save money too in the short term. Whilst public-private sector partnerships to manage town and city centers have a number of established tried and tested models across the European Union, the role of the private sector (including Business Improvement Districts) in leading environmental stewardship at this level remains an area in need of further research. This paper explores practice-based evidence in this field (e.g. sustainable business procurement) and discusses potential avenues for further work with recommendations for policy makers and key decision makers at city management level.

Radiofrequency ablations (RFA), a new therapeutic option for liver metastases, proceeded by open surgery or laparoscopic approach, provide an acceptable control of local tumor process, involved lower risks than resection surgery.We analyzed this procedure, for classic indication in hepatic metastatic tumors, based on four years experience, focused on perioperative complications, recurrence rate and long distant evolution.Between December 2006 and December 2010, 61 patients with liver metastases underwent RFA; 46 cases had metastatic lesions from colo-rectal cancer, 9 cases from breast cancer, 4 cases from gastric cancer and 2 cases from ovarian cancer. RFA was performed in 55 patients via open surgery and laparoscopic approach in 6 patients. Postoperative course was followed with CT scan at 1 month, and then at 3 month interval, in correlation with tumor markers level.Perioperative complications occurred in 8 cases, consist of prolonged fever, severe hepatic cytolysis, without other complications such, biliary tract injury, hemorrhage, and peritonitis; no mortality caused by RFA procedure. 10 cases had local recurrence, at 6 and 25 month after post RFA procedure.Initial experience shows that RFA is a safe procedure for treatment of liver metastases, with low rate of morbidity and local recurrence, indicated for patients with unresecable lesions or high risks for surgical resection.

This study aimed to evaluate the optimal conditions for laparoscopic management of neonatal subacute volvulus with malrotation.Between 1994 and 2002, 13 neonates with midgut volvulus and malrotation entered the authors' institution. Five of these neonates met the eligibility criteria for laparoscopy: good hemodynamic parameters, no gut perforation, and no severe ischemic distress of the bowel shown on preoperative ultrasonography.The results were excellent for only three infants, associated with a shorter postoperative course. One underwent reoperation for a residual duodenal band, and one conversion to open laparotomy was necessary. The predictors of success were no difficulty identifying the abnormal anatomy, no important chylous stasis, and the learning curve of the surgeon.Despite its previously reported feasibility, neonatal laparoscopy for volvulus with intestinal malrotation is appropriate only for a small number of patients. Strict selection criteria with a clear understanding of the optimal conditions for success may improve the outcome.

The role of prostaglandin at the level of the female genital system is multiple; they are involved in ovulation, luteolysis, contractility of the tube muscles, contraction of the gravid uterus, dilatation of the cervix. The synthetic analogous of the prostaglandin F2 alpha are utilized in a large area of treatments, for multiple purposes. The study was made on 2 lots with 10 non pregnant female guinea pig: the first lot was the witness lot and didn't receive any substance. The second lot received 100 micrograms/kg/day Isopropyl ester PGF2 alpha. The prostaglandin analogous produces vasodilating effects on the ovary blood vessels and luteolytic effects with the destruction of the ovarian follicles.

The Adrenal glands can be viewed as sustaining vital processes in the human body, through two different but related components: the cortex and the medulla. It is well known that the close connection between the cortical cells is able not only to support the adrenal functions, but in the same time to serve the better understanding of the normal way of its hormonal production. Using the ultrastructural study of the adrenal gland, we obtain images which can provide informations about details of the cellular structure, in the eventuality that all this work will continue to improve to the point that we might be able to completely understand the complex interrelations between the structure of each cell and the function of the whole organ.

We evaluated the frequency of elevated intraocular pressure (IOP) the first 1-3 postoperative days for a group of patients undergoing standard or phacoemulsification extracapsular cataract extraction (ECCE). IOP was measured in the pre and postoperative period using non-contact tonometer. From the 356 operated patients, 21 patients (6%) had early elevated IOP. The frequency of elevated IOP was greater among the patients that received anterior chamber (AC) IOL (25%) as compared to that of patients that received posterior chamber (PC) IOL (5.5%). The viscoelastic substance was responsible for a great percentage of cases (51%). The results show that the majority of elevated IOP is transient, recovered spontaneously or by treatment with carbonic anhydrase inhibitors or beta-adrenergic blockers. Elevated postoperative IOP occurs more frequently in the presence of glaucoma, cataract associated with systemic diseases, in complicated and traumatic cataract.

This paper presents theoretical aspects concerning the physiopathological mechanisms involved in producing the glaucoma following trauma, especially the lens related glaucoma, correct identification of the ethiopathogeny of the intraocular pressure elevation in this situation is essential for the appropriate management. These aspects are illustrated by two cases of recent glaucoma following trauma lens related (lens subluxation) treated by medication and surgery. The surgical procedure consisted of intracapsular extraction of the lens, anterior vitrectomy, iridectomy and implantation of sulcus sutured posterior chamber lens. We present the technique, the difficulties met intra- and postoperative, evolution and prognosis.

The purpose of this project was to 1) assess the disposition kinetics of [3H]-cholesterol following co-administration with a novel hydrophilic compound, FM-VP4, and 2) determine the pharmacokinetics, tissue distribution and excretion of [3H]FM-VP4 following single oral (150 mg/kg which includes 100 mCi of radiolabel) and intravenous (15 mg/kg which includes 10 mCi of radiolabel) doses.Following an overnight fast (12-16 h) and 48 h post-surgery, adult male Sprague Dawley rats were divided into six treatment groups (n=4/group). Groups received single oral doses of 25 mCi/ml [3H]cholesterol alone or with 5, 10, 20, 50 and 100 mg/kg FM-VP4 at 0700 h. Ten percent Intralipid was used to solubilize and co-administer [3H]-cholesterol and FM-VP4. LC-MS analysis confirmed minimal cholesterol and vegetable stanol content within 10% Intralipid. Thin layer chromatography was used to confirm that the majority of radioactivity measured in plasma was associated with either esterified or unesterified cholesterol. In a second study pharmacokinetics of [3H]FM-VP4 were studied following intravenous or orally gavaged doses (n=8). Tissues, urine and feces were also collected in FM-VP4 kinetics study to measure tissue distribution of radioactivity. Plasma [3H]-cholesterol and [3H]FM-VP4 were tested for radioactivity.FM-VP4 co-administration significantly decreased [3H]-cholesterol AUC0-48h and Cmax, and increased CL/F and Vd/F of [3H]-cholesterol as compared to controls in a dose-dependent manner. Following oral administration of [3H]FM-VP4, the majority of radioactivity following was recovered in the feces and gastrointestinal (GI) tract. The compound exhibited an oral bioavailability of 6.5%. Following IV administration, a two-compartment pharmacokinetic model was observed and the majority of the radioactivity was recovered in the GI tract.FM-VP4 reduces plasma concentration of [3H]-cholesterol in fasting rats. [3H]FM-VP4 has a very low oral bioavailability.

The most important factor for functional and anatomic prognosis of an injured eye is the appropriate emergency assistance. This paper presents a case of penetrating ocular trauma with minor clinical sings which associates severe lesions of posterior pole discovered intraoperatively. Careful history and clinical examination allowed the best surgical management, with complete anatomical and functional recovery of the eye.

Ocular onset is seldom for an arachnoid cyst. We present the case of a young man whose only symptom when hospitalized, was the unilateral peripheral field contraction. It was afterwards specified the presence of the arachnoid cyst and it's pathogenic feature, the compression of the optic nerve.

This paper presents the case of a pacient operated for organized hemoftalmus after central retinal vein thrombosis (total vitrectomy) and whom five days after surgery a macular hole was observed and internal indendation with gas was performed. Postoperative evolution was good. Two months after surgery the pacient returns with cvasitotal regmatogen retinal detachment. The possible causes in bringing about of the retinal detachment in this case will be discussed as well as the factors that condition the success in posterior pole surgery.

This paper presents two cases of corneal abscess and their therapeutically approach which was the surgical treatment (penetrant keratoplasty). First case was a corneal ulcer which failed to abscess under medical therapy. The second case was a corneal abscess complicated with impending perforation after intracorneal foreign body. The particular aspects for each case are emphasized as well as the common aspects for corneal infections summarized as an algorithm.

Fine-needle biopsy is used in the thyroid pathology especially for the differential diagnosis concerning malignant lesions. From a total of 59 cases of thyroiditis, in 12 was possible to proceed to fine-needle biopsy, in large goiters and nodules larger than 1 cm in diameter; in these cases were obtained smears, stained in May-Grünwald-Giemsa technique. In 9 cases of the 12 investigated, in the smears appeared lymphocytes and macrophages, cells commonly found in the infiltrates of the thyroid gland, in autoimmune thyroiditis, and sometimes also few normal thyrocytes. Fine-needle biopsy is important in the diagnosis algorithm of the thyroid nodules, involving 4, up to 7% of the general population. It has also the advantage of reducing the number of cases solved by surgical therapy, as it is the case with the diagnosis of Hashimoto's thyroiditis.

This work is based on dissection and the analysis of the arteriographies of two mesenteric arteries and it analyses the type of intermesenteric anastomoses and their importance in surgical practice. The morphological varieties of Riolan's arcade depends on its pillars, as well as on the eventual presence, especially in the middle part of the transversal mesocolon, of the secondary arcades; it seems that the colic wall necrosis depends less upon the location of the lesion or the level of the suture of the arcade, but more so on the stretch of the destruction of the mesocolon. The intermesenteric trunk, a second way of intermesenteric anastomoses is a embryological remaining, non-functional in normal conditions, but capable to partially or completely replace the Riolan's arcade when the later is sutured or interrupted.

The selection of the material for this study was governed by the idea that at the newborn like at the adult, the cortex of the adrenal gland is complete, including all the three zones, while medulla is not structured until 12-36 month; for this reason, we used only the cellular cortical elements. The quantitative method of evaluation of the cellular diameter, as well as the interpreting and correlation of the values with age, have confirmed that the dynamics of the cellular components of the adrenal gland depends on age, indicating significant differences. The cell diameter is usually bigger at the newborn compared with the adult (with zonal variations). The variability is relatively small which means that the individual values are placed in a limited field.

The aim of our study is to point out the influence of the cerebral development on the evolution of the middle cerebral artery (MCA) system. Brains of 20 fresh fetuses (16-22 weeks) were injected with gelatin-ink China mixture, observed and dissected under surgical microscope in correlation with the evolution of the sylvian fossa. Ending pattern of MCA and territories of distribution of its branches were also discussed.

Introduction L’etude du systeme distributif de l’artere mesenterique inferieure (AMI) concerne le mode de distribution parietale au niveau du colon gauche et de la portion superieure du rectum. Les arcades paracolique et parasygmoidienne sont formees par l’anastomose de deux collaterales de l’AMI, fait qui reduit la vitesse de circulation du sang, mais elle entraine une pression laterale elevee, necessaire a la penetration dans les vaisseaux droits. Materiel et methodes 100 sujets, avec injection des arteres mesenteriques. Resultats et discussion Dans les cas etudies, nous avons mis en evidence trois modes principaux d’emergence des vaisseaux coliques. a) par tronc commun (situation rare) – de l’arcade se separe un rameau plus grand qui, immediatement apres l’origine, se separe dichotomiquement. L’angle de division est obtus, chacun des rameaux de bifurcation se comporte comme un vaisseau parietal colique independant, avec une seconde bifurcation pres de la limite du meso-colon. b) par tronc unique avec une bifurcation precoce – situation la plus frequente, dans laquelle le rameau parietal colique (RPC) se separe immediatement apres l’origine, l’angle de bifurcation etant aigu et a distance du colon. c) par tronc commun, avec bifurcation juxtacolique – le RPC parcourt la distance entre l’arcade et le colon et, juxtacolique, se separe dans les deux rameaux, avec un angle de presque 90 degres. Les RPC sont donc separes dans deux grandes categories : I. Les RPC symetriques, qui suivent un des trois modeles deja discutes, et qui d’apres leur longueur sont separes en longs (RPCSL) – avec un segment mesocolique et un segment sous-sereux courts (RPCSC) II. Les RPC asymetriques (en nombre de 5-15) – sur toute la surface du colon gauche, avec un trajet exclusivement intramesocolique. L’existence de ces rameaux assure une bonne vascularisation de la limite mesocolique du colon et leur presence dans la region de suture chirurgicale constitue le premice favorable de la viabilite de l’angle critique

Introduction Cetaria islandica presente de reelles proprietes antioxydantes, qui sont bien connues au niveau du parenchyme hepatique. Cette experimentation veut demontrer l’existence ou l’absence de cet effet dans le rein. Materiel et methode Nous avons utilise 4 groupes distincts de 10 rats dont le poids variait entre 160 et 180 g. Le premier groupe a ete considere comme controle ; le deuxieme groupe a ete traite pendant 12 jours avec un extrait de Cetaria islandica (86,25 mg/kg/j par voie intraperitoneale) ; le troisieme groupe a ete maintenu dans l’obscurite pendant 12 jours (stress oxydatif) ; le quatrieme groupe a ete maintenu dans l’obscurite et traite avec la meme dose d’extrait de Cetaria islandica pendant 12 jours. A la fin de l’experience, nous avons sacrifie les animaux, preleve les reins qui ont ete analyses histologiquement. Resultats et discussions Le groupe controle presentait un rein normal ; le deuxieme groupe n’a pas presente d’alterations renales produites par Cetaria ; le troisieme groupe presentait seulement un faible contour tubulaire renal et un profil glomerulaire plus fort ; le dernier groupe presentait les memes alterations que le troisieme groupe. Conclusions Cetaria islandica possede des proprietes antioxydantes au niveau du parenchyme hepatique. Par compte, ce compose ne joue pas un tel role au niveau du rein.