1. Evidence for interaction between genetic liability and childhood trauma in the development of psychotic symptoms
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Ruud van Winkel, Sinan Guloksuz, Jeroen Decoster, Dina Collip, Antonius Petrus Wilhelmus Smeets, Claudia Menne-Lothmann, Thomas Vaessen, Nele Jacobs, Florentina M. E. Pinckaers, Marjan Drukker, Philippe Delespaul, Iris Leah Marije Rotee, Annika Theresia Schäfer, Catherine Derom, Marieke Wichers, Aniek Uittenboogaard, C. Vicky Nwosu, Lea de Jong, Evert Thiery, Jim van Os, Bart P. F. Rutten, Marc De Hert, Thomas Damen, Pauline Krolinski, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Section Lifespan Psychology, RS-Research Line Lifespan psychology (part of IIESB program), Promovendi CD, Psychiatrie & Neuropsychologie, RS: MHeNs - R2 - Mental Health, Promovendi MHN, MUMC+: MA Psychiatrie (3), RS: MHeNs - R3 - Neuroscience, and MUMC+: Hersen en Zenuw Centrum (3)
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DISORDER ,Male ,Health (social science) ,Epidemiology ,Emotions ,Poison control ,Psychotic symptoms ,Childhood trauma ,0302 clinical medicine ,Risk Factors ,Surveys and Questionnaires ,SCHIZOPHRENIA ,Medicine and Health Sciences ,030212 general & internal medicine ,POLYGENIC RISK ,FAMILIAL RISK ,Child Abuse ,Genetic liability ,ENVIRONMENT INTERACTIONS ,Child ,education.field_of_study ,PSYCHOPATHOLOGY ,General population ,DEPRESSION ,Psychiatry and Mental health ,Schizophrenia ,Female ,Symptom Assessment ,Clinical psychology ,Psychopathology ,Adult ,Psychosis ,Social Psychology ,Population ,TWIN ,MECHANISMS ,Health(social science) ,03 medical and health sciences ,Injury prevention ,medicine ,Journal Article ,Humans ,Genetic Predisposition to Disease ,Risk factor ,Gene–environment interaction ,education ,business.industry ,medicine.disease ,Gene-environment interaction ,030227 psychiatry ,PSYCHOMETRIC PROPERTIES ,Sexual abuse ,Psychotic Disorders ,business - Abstract
PURPOSE: Whilst childhood trauma (CT) is a known risk factor across the spectrum of psychosis expression, little is known about possible interplay with genetic liability. METHODS: The TwinssCan Study collected data in general population twins, focussing on expression of psychosis at the level of subthreshold psychotic experiences. A multilevel mixed-effects linear regression analysis was performed including 745 subjects to assess the interaction between genetic liability and CT. The Symptom Checklist-90 (SCL-90-R) score of the co-twin was used as an indirect measure of genetic liability to psychopathology, while the Childhood Trauma Questionnaire Short-Form (CTQ-SF) was used to assess CT in the domains of physical, emotional and sexual abuse, as well as physical and emotional neglect. The Community Assessment of Psychic Experience (CAPE) questionnaire was used to phenotypically characterize psychosis expression. RESULTS: In the model using the CAPE total score, the interaction between CT and genetic liability was close to statistical significance (χ2 = 5.6, df = 2, p = 0.06). Analyses of CAPE subscales revealed a significant interaction between CT and genetic liability (χ2 = 8.8, df = 2, p = 0.012) for the CAPE-negative symptoms subscale, but not for the other two subscales (i.e. positive and depressive). CONCLUSION: The results suggest that the impact of CT on subthreshold expression of psychosis, particularly in the negative subdomain, may be larger in the co-presence of significant genetic liability for psychopathology. ispartof: SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY vol:54 issue:9 pages:1045-1054 ispartof: location:Germany status: published
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- 2019
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