1. Integrated probability of coronary heart disease subject to the −308 tumor necrosis factor-alpha SNP: a Bayesian meta-analysis
- Author
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C. Sofia Carvalho
- Subjects
Bayesian meta-analysis ,Coronary heart disease ,−308 TNF-alpha ,Medicine ,Biology (General) ,QH301-705.5 - Abstract
We present a meta-analysis of independent studies on the potential implication in the occurrence of coronary heart disease (CHD) of the single-nucleotide polymorphism (SNP) at the −308 position of the tumor necrosis factor alpha (TNF-alpha) gene. We use Bayesian analysis to integrate independent data sets and to infer statistically robust measurements of correlation. Bayesian hypothesis testing indicates that there is no preference for the hypothesis that the −308 TNF-alpha SNP is related to the occurrence of CHD, in the Caucasian or in the Asian population, over the null hypothesis. As a measure of correlation, we use the probability of occurrence of CHD conditional on the presence of the SNP, derived as the posterior probability of the Bayesian meta-analysis. The conditional probability indicates that CHD is not more likely to occur when the SNP is present, which suggests that the −308 TNF-alpha SNP is not implicated in the occurrence of CHD.
- Published
- 2015
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