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Geomagnetically Induced Currents (GIC) constitute an integral part of space weather research and are a subject of ever-growing attention for countries located in the low and middle latitudes. A series of recent studies highlights the importance of considering GIC risks for the Mediterranean region. Here, we exploit data from the HellENIc GeoMagnetic Array (ENIGMA), which is deployed in Greece, complemented by magnetic observatories in the Mediterranean region (Italy, France, Spain, Algeria and Turkey), to calculate values of the GIC index, i.e., a proxy of the geoelectric field calculated entirely from geomagnetic field variations. We perform our analysis for the most intense magnetic storms (Dst < -150 nT) of solar cycle 24. Our results show that GIC index increases are well correlated with Storm Sudden Commencements (SSCs). However, the GIC indices do not exceed “low” activity levels despite the increases in their values, at all magnetic stations / observatories under study during the selected storm events.

IMPORTANCE: Loss of smell is an early and common presentation of COVID-19 infection. Although it has been speculated that viral infection of olfactory neurons may be the culprit, it is unclear whether viral infection causes injuries in the olfactory bulb region. OBJECTIVE: To characterize the olfactory pathology associated with COVID-19 infection in a postmortem study. DESIGN, SETTING, AND PARTICIPANTS: This multicenter postmortem cohort study was conducted from April 7, 2020, to September 11, 2021. Deceased patients with COVID-19 and control individuals were included in the cohort. One infant with congenital anomalies was excluded. Olfactory bulb and tract tissue was collected from deceased patients with COVID-19 and appropriate controls. Histopathology, electron microscopy, droplet digital polymerase chain reaction, and immunofluorescence/immunohistochemistry studies were performed. Data analysis was conducted from February 7 to October 19, 2021. MAIN OUTCOMES AND MEASURES: (1) Severity of degeneration, (2) losses of olfactory axons, and (3) severity of microvasculopathy in olfactory tissue. RESULTS: Olfactory tissue from 23 deceased patients with COVID-19 (median [IQR] age, 62 [49-69] years; 14 men [60.9%]) and 14 control individuals (median [IQR] age, 53.5 [33.25-65] years; 7 men [50%]) was included in the analysis. The mean (SD) axon pathology score (range, 1-3) was 1.921 (0.569) in patients with COVID-19 and 1.198 (0.208) in controls (P

In this paper, we worked in the framework of an inflationary $f(R,T)$ theory, in the presence of a canonical scalar field. More specifically, the $f(R,T)=\gamma R+2\kappa\alpha T$ gravity. The values of the dimensionless parameters $\alpha$ and $\gamma$ are taken to be $\alpha \geq 0$ and $0 < \gamma \leq 1$. The motivation for that study was the striking similarities between the slow-roll parameters of the inflationary model used in this work and the ones obtained by the rescaled Einstein-Hilbert gravity inflation $f(R)=\alpha R$. We examined a variety of potentials to determine if they agree with the current Planck Constraints. In addition, we checked whether these models satisfy the Swampland Criteria and we specified the exact region of the parameter space that produces viable results for each model. As we mention in Section IV the inflationary $f(R,T)$ theory used in this work can not produce a positive $n_T$ which implies that the stochastic gravitational wave background will not be detectable., Comment: IJMPD Accepted

Objective The study aimed to assess the impact of the coronavirus disease 2019 (COVID-19) pandemic on head and neck oncologic care at a tertiary care facility. Study Design This was a cross-sectional study conducted between March 18, 2020, and May 20, 2020. The primary planned outcome was the rate of treatment modifications during the study period. Secondary outcome measures were tumor conference volume, operative volume, and outpatient patient procedure and clinic volumes. Setting This single-center study was conducted at a tertiary care academic hospital in a large metropolitan area. Methods The study included a consecutive sample of adult subjects who were presented at a head and neck interdepartmental tumor conference during the study period. Patients were compared to historical controls based on review of operative data, outpatient procedures, and clinic volumes. Results In total, 117 patients were presented during the review period in 2020, compared to 69 in 2019. There was an 8.4% treatment modification rate among cases presented at the tumor conference. There was a 61.3% (347 from 898) reduction in outpatient clinic visits and a 63.4% (84 from 230) reduction in procedural volume compared to the prior year. Similarly, the operative volume decreased by 27.0% (224 from 307) compared to the previous year. Conclusion Restrictions related to the COVID-19 pandemic resulted in limited treatment modifications. Transition to virtual tumor board format observed an increase in case presentations. While there were reductions in operative volume, there was a larger proportion of surgical cases for malignancy, reflecting the prioritization of oncologic care during the pandemic.

Salivary duct carcinoma of the parotid gland is a highly aggressive epithelial malignancy morphologically resembling high-grade, invasive, and in situ breast carcinoma. It can occasionally present with variable morphology making it diagnostically challenging in cases with unusual morphological components. Ancillary testing, particularly androgen receptor (AR) positivity on immunohistochemistry, can be very helpful in cases that demonstrate extensive squamous morphology, since AR positivity is uncommon in both the primary salivary gland and metastatic squamous cell carcinomas to the parotid. In this report, we describe a case of salivary duct carcinoma that showed only a squamous cell carcinoma component on the initial primary tumor site biopsy, as well as in subsequent contralateral neck lymph node and skin metastases. Apart from the variable morphology, the typical salivary duct and squamous cell carcinoma tumor components also showed significant immunohistochemical differences, including differential staining of human epidermal growth factor receptor 2/neu. The associated diagnostic pitfalls, distinct immunoprofiles of the tumor components, helpful adjuncts for making the correct diagnosis, and associated therapeutic implications are discussed.

Rate coefficients, k, for the gas-phase Cl + Furan-2,5-dione (C4H2O3, maleic anhydride) reaction were measured over the 15–500 torr (He and N2 bath gas) pressure range at temperatures between 283 and 323 K. Kinetic measurements were performed using pulsed laser photolysis (PLP) to produce Cl atoms and atomic resonance fluorescence (RF) to monitor the Cl atom temporal profile. Complementary relative rate (RR) measurements were performed at 296 K and 620 torr pressure (syn. air) and found to be in good agreement with the absolute measurements. A Troe-type fall-off fit of the temperature and pressure dependence yielded the following rate coefficient parameters: ko(T) = (9.4 ± 0.5) × 10−29 (T/298)−6.3 cm6 molecule−2 s−1, k∞(T) = (3.4 ± 0.5) × 10−11 (T/298)−1.4 cm3 molecule−1 s−1. The formation of a Cl·C4H2O3 adduct intermediate was deduced from the Cl atom temporal profiles and an equilibrium constant, KP(T), for the Cl + C4H2O3 ↔ Cl·C4H2O3 reaction was determined. A third-law analysis yielded ΔH = −15.7 ± 0.4 kcal mol−1 with ΔS = −25.1 cal K−1 mol−1, where ΔS was derived from theoretical calculations at the B3LYP/6-311G(2d,p,d) level. In addition, the rate coefficient for the Cl·C4H2O3 + O2 reaction at 296 K was measured to be (2.83 ± 0.16) × 10−12 cm3 molecule−1 s−1, where the quoted uncertainty is the 2σ fit precision. Stable end-product molar yields of (83 ± 7), (188 ± 10), and (65 ± 10)% were measured for CO, CO2, and HC(O)Cl, respectively, in an air bath gas. An atmospheric degradation mechanism for C4H2O3 is proposed based on the observed product yields and theoretical calculations of ring-opening pathways and activation barrier energies at the CBS-QB3 level of theory.

Atmospheric simulation chambers, are unique tools for investigating atmospheric processes in the gas and heterogeneous phases. They can provide a controlled yet realistic environment that simulates atmospheric conditions. In the current study, a Teflon atmospheric simulation chamber of 600 L, named THALAMOS (thermally regulated atmospheric simulation chamber) has been developed and cross-validated. THALAMOS can be operated over the temperature range 233 to 373 K under both static and flow conditions. It is equipped with state of the art instrumentation (selective ion flow tube mass spectrometry (SIFT-MS), long path Fourier transform infrared spectroscopy (FTIR), gas chromatography-mass spectrometry (GC-MS), various analyzers) for the in-line monitoring of both reactants and products. THALAMOS was validated by measuring the rate coefficients of well documented reactions, i.e. the reaction of ethanol with OH radicals and the reaction of dichloromethane with Cl atoms, in a wide temperature range. Two different detection techniques were used in parallel, FTIR and SIFT-MS, to internally cross-validate the obtained results. The measured rate coefficients are in excellent agreement, both between each other and with the literature recommended values. Furthermore, the gas phase oxidation of toluene by Cl atoms (kinetics and product yields) was studied in the temperature range of 253 to 333 K. To the best of our knowledge, THALAMOS is a unique facility on national level and among a few smog chambers internationally that can be operated in such a wide temperature range providing the scientific community with a versatile tool to simulate both outdoor and indoor physicochemical processes.

Perfluorodicarbonyl (PFDC) compounds may be emitted directly into the atmosphere or formed in the atmospheric degradation of trace fluorinated gases, such as unsaturated perfluoro cyclic compounds. A potential atmospheric removal process for PFDCs is UV photolysis, which is presently not well-characterized. In this work, UV and infrared absorption spectra of FC(O)C(O)F, FC(O)CF2C(O)F, and FC(O)CF2CF2C(O)F (three of the simplest PFDCs) and their 248 nm photolysis products are reported. UV spectra were measured at 296 K between 190 and 320 nm using single wavelength and broadband diode array spectroscopic measurement techniques. Infrared absorption spectra were measured at 296 K using Fourier transform infrared spectroscopy between 500 and 4000 cm-1. The PFDCs are shown to be potent greenhouse gases with radiative efficiencies (well-mixed) of 0.142, 0.218, and 0.293 W m-2 ppb-1 for FC(O)C(O)F, FC(O)CF2C(O)F, and FC(O)CF2CF2C(O)F, respectively. Photolysis product yields (248 nm) were measured using pulsed laser photolysis combined with infrared absorption detection of radical products scavenged to stable bromides by reaction with Br2. BrC(O)F was identified as a major stable end product in all systems with a yield greater than ∼90%. The infrared spectrum of BrC(O)F is reported as part of this study. FC(O)CBrF2 and FC(O)CF2CBrF2 were also identified as products in the photolysis of FC(O)CF2C(O)F and FC(O)CF2CF2C(O)F, respectively, by comparison with theoretically calculated infrared absorption spectra. A carbonyl difluoride (CF2O) primary photolysis yield of ∼10% was measured in the photolysis of FC(O)C(O)F.

Ghost cell odontogenic carcinoma (GCOC) is a rare malignant tumor of odontogenic origin, with only about 50 cases reported in the English literature so far. Histologically, it is characterized by ghost cells, dentinoid deposits, high grade malignant cellular features, and areas of necrosis and invasion. Having common histological features with other odontogenic ghost cell lesions (OGCL) like calcifying odontogenic cyst (COC) and dentinogenic ghost cell tumors, it is crucial to recognize GCOC malignant features, as it can be destructive and invasive, sometimes showing distant metastases and high recurrence rate. For this reason, it may entail more aggressive surgical approach and multimodal therapeutic regimen. Here we present a case report of GCOC arising in a previous COC, treated with surgical excision that showed persistence and recurrence after two years. The clinical and histological features of this rare occurrence are presented, in addition to the surgical approach, and a summary of literature review of OGCL.

Geospace disturbances refer collectively to the variations of the geomagnetic field and the trapped particle populations in the near-Earth space. These are the result of transient and recurrent solar activity, which consequently drives the variable solar wind. They may appear in multiple timescales, from sub-seconds to days, months and years. Wavelet analysis is one of the most popular, and powerful, methods in the study of these variations, as it allows for the local decomposition of non-stationary time series in frequency (or time-scale) and time simultaneously. This article is a review of the wavelet methods used in the investigation of geomagnetic field oscillations, which underlines their advantages as spectral analysis methods and demonstrates their utilization in the interdependence of multiple time-series. Lastly, the proper methodology for the accurate estimation of the power inferred from geophysical signals, applicable in quantitative studies, is included and is publicly available at the database of the University of Athens. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

In this work we shall use a bottom-up approach for obtaining viable inflationary Einstein-Gauss-Bonnet models which are also compatible with the GW170817 event. Specifically, we shall use a recently developed theoretical framework in which we shall specify only the tensor-to-scalar ratio, in terms of the $e$-foldings number. Starting from the tensor-to-scalar ratio, we shall reconstruct from it the Einstein-Gauss-Bonnet theory which can yield such a tensor-to-scalar ratio, finding the scalar potential and the Gauss-Bonnet coupling scalar function as functions of the $e$-foldings number. Accordingly, the calculation of the spectral index of the primordial scalar perturbations, and of the tensor spectral index easily is greatly simplified and these observational indices can easily be found. After presenting the general formalism for the bottom-up reconstruction, we exemplify our findings by presenting several Einstein-Gauss-Bonnet models of interest which yield a viable inflationary phenomenology. These models have also an interesting common characteristic, which is a blue tilted tensor spectral index. We also investigate the predicted energy spectrum of the primordial gravitational waves for these Einstein-Gauss-Bonnet models, and as we show, all the models yield a detectable primordial wave energy power spectrum., Comment: CQG accepted, some typos corrected, one author name modified, doi added

Background Chronic rhinosinusitis (CRS) causes a great deal of morbidity. There are a multitude of causal factors, though their precise contribution to symptom severity has yet to be defined. We hypothesized that exposure to both primary and secondhand tobacco smoke would correlate with more severe symptoms of CRS. Methods This is a prospective cross-sectional study performed at an academic tertiary care medical center from 2010 to 2013. A total of 85 consecutive patients with chronic sinusitis were screened; 70 with medically refractory CRS requiring functional Endoscopic sinus surgery (FESS) were enrolled. Recent tobacco exposure was assessed using serum cotinine levels. Sinonasal mucosa was biopsied to assess ciliary architecture. Demographics, medical history, tobacco and environmental exposures, and computed tomography (CT) imaging were also collected. Two quality of life (QOL) surveys were administered: one disease specific, Sinonasal Outcomes Test-20 (SNOT-20), and one general, Short Form-12 (SF-12). Results were correlated with the aforementioned exposures. Results The 70 patients had an average age of 46 years, and 42% were male. Variables that correlated with worse SNOT-20 scores included serum cotinine (r = 0.43, p = 0.002), number of cigarettes smoked daily (r = 0.27, p = 0.03), and number of secondhand cigarettes exposed to per day (r = 0.29, p = 0.04). There were no significant correlations between SNOT-20 scores and Lund-MacKay or axonemal ultrastructural abnormalities (AUA)-ciliary scores. The two five-variable models best predicted disease-specific QOL. Conclusions Increased amounts of serum cotinine and primary and secondhand smoke exposure were associated with worse sinonasal QOL. This study establishes an objective relationship between smoke exposure and patient-perceived severity of CRS, emphasizing the importance of tobacco cessation counseling as part of management.

Introduction Routine C4d staining in renal transplantation has stimulated its use in kidney biopsies with glomerulonephritis (GN). Methodical description on staining patterns in the native kidney is not available. Methods We retrospectively evaluated C4d staining in formalin-fixed paraffin-embedded sections from 519 native kidney biopsies (bx) with and without glomerular disease. Results Strong C4d staining was consistently present in immune-complex GN, including lupus nephritis (LN) (n = 68), membranous GN (n = 24), membranoproliferative glomerulonephritis (MPGN) pattern (n = 22), fibrillary GN (n = 3), and proliferative GN with monoclonal IgG (n = 3). C4d stained all cases of postinfectious GN (n = 7) amyloidosis (n = 20) and C1q GN (n = 3). In contrast, IgA nephropathy (IgAN) (n = 34), was negative in 62% of bx, with the rest staining variably. The E1 Oxford classification score correlated with capillary wall C4d staining (P = 0.05). C4d marked the glomerular and arteriolar lesions in thrombotic microangiopathy (TMA; n = 16), the glomerular sclerotic segments in focal segmental glomerulosclerosis (FSGS; n = 77), and marked areas of necrosis in crescentic GN (n = 21). In diabetic glomerulopathy (n = 70), C4d marked advanced insudative lesions but was negative otherwise. C4d weakly stained the mesangium, or was negative in normal biopsies (n = 13), minimal change disease (MCD; n = 21), thin basement membrane disease (n = 20), Alport (n = 3), IgM nephropathy (n = 2), C3 glomerulopathy (n = 5), acute interstitial nephritis (n = 12), acute tubular necrosis (n = 22), ischemic glomerulopathy/nephrosclerosis (n = 23), and other miscellaneous processes (n = 14). Staining in tubular basement membranes and peritubular capillaries was most common in lupus. Conclusion Based on reliable staining in lupus and membranous GN, C4d staining is potentially useful as a screening and diagnostic tool, if only paraffin-embedded tissue is available. Knowledge of C4d staining patterns in normal and pathological tissues enhances its diagnostic value., Graphical abstract

Adrenal pseudocysts are a subclass of adrenal cysts frequently found as incidentalomas. Here, we present the case of a 67-year-old man with an adrenal pseudocyst suspicious for hemorrhage after a fall who was urgently transferred to a tertiary care trauma center for care.

Semaphorin 4D (Sema4D) is a glycoprotein that is expressed by several tumors and immune cells. It can function as a membrane bound protein or as a cleaved soluble protein (sSema4D). We sought to investigate the translational potential of plasma sSema4D as an immune marker in plasma of patients with head and neck squamous cell carcinoma (HNSCC). Paired peripheral blood and tumor tissue samples of 104 patients with HNSCC were collected at the same time point to allow for real time analysis. Scoring of the histological inflammatory subtype (HIS) was carried out using Sema4D immunohistochemistry on the tumor tissue. sSema4D was detected in plasma using direct ELISA assay. Defining elevated sSema4D as values above the 95th percentile in healthy controls, our data showed that sSema4D levels in plasma were elevated in 25.0% (95% CI, 16.7–34.9%) of the patients with HNSCC and showed significant association with HIS immune excluded (HIS-IE) (p = 0.007), Sema4D+ve tumor cells (TCs) (p = 0.018) and PD-L1+ve immune cells (ICs) (p = 0.038). A multi-variable logistic regression analysis showed that HIS was significantly (P = 0.004) associated with elevated sSema4D, an association not explained by available patient-level factors. Using the IO-360 nanoString platform, differential gene expression (DGE) analysis of 10 HNSCC tumor tissues showed that patients with high sSema4D in plasma (HsS4D) clustered as IFN-γ negative tumor immune signature and were mostly HIS-IE. The IC type in the HsS4D paired tumor tissue was predominantly myeloid, while the lymphoid compartment was higher in the low sSema4D (LsS4D). The Wnt signaling pathway was upregulated in the HsS4D group. Further analysis using the IO-360, 770 gene set, showed significant non-inflamed profile of the HsS4D tumors compared to the LsS4D. In conclusion, our data reveals an association between sSema4D and the histological inflammatory subtype.

Background In the phase III IMpassion130 trial, combining atezolizumab with first-line nanoparticle albumin-bound-paclitaxel for advanced triple-negative breast cancer (aTNBC) showed a statistically significant progression-free survival (PFS) benefit in the intention-to-treat (ITT) and programmed death-ligand 1 (PD-L1)-positive populations, and a clinically meaningful overall survival (OS) effect in PD-L1-positive aTNBC. The phase III KEYNOTE-355 trial adding pembrolizumab to chemotherapy for aTNBC showed similar PFS effects. IMpassion131 evaluated first-line atezolizumab–paclitaxel in aTNBC. Patients and methods Eligible patients [no prior systemic therapy or ≥12 months since (neo)adjuvant chemotherapy] were randomised 2:1 to atezolizumab 840 mg or placebo (days 1, 15), both with paclitaxel 90 mg/m2 (days 1, 8, 15), every 28 days until disease progression or unacceptable toxicity. Stratification factors were tumour PD-L1 status, prior taxane, liver metastases and geographical region. The primary endpoint was investigator-assessed PFS, tested hierarchically first in the PD-L1-positive [immune cell expression ≥1%, VENTANA PD-L1 (SP142) assay] population, and then in the ITT population. OS was a secondary endpoint. Results Of 651 randomised patients, 45% had PD-L1-positive aTNBC. At the primary PFS analysis, adding atezolizumab to paclitaxel did not improve investigator-assessed PFS in the PD-L1-positive population [hazard ratio (HR) 0.82, 95% confidence interval (CI) 0.60-1.12; P = 0.20; median PFS 6.0 months with atezolizumab–paclitaxel versus 5.7 months with placebo–paclitaxel]. In the PD-L1-positive population, atezolizumab–paclitaxel was associated with more favourable unconfirmed best overall response rate (63% versus 55% with placebo–paclitaxel) and median duration of response (7.2 versus 5.5 months, respectively). Final OS results showed no difference between arms (HR 1.11, 95% CI 0.76-1.64; median 22.1 months with atezolizumab–paclitaxel versus 28.3 months with placebo–paclitaxel in the PD-L1-positive population). Results in the ITT population were consistent with the PD-L1-positive population. The safety profile was consistent with known effects of each study drug. Conclusion Combining atezolizumab with paclitaxel did not improve PFS or OS versus paclitaxel alone. ClinicalTrials.gov NCT03125902.

This paper identifies and analyses the practices in the EU countries aiming to identify gaps and barriers for integrating the emerging technologies RES, storage, Electric Vehicles (EVs) and Demand Response flexibility (DR) in existing grid codes. For this reason, an extended analysis was performed to both the Existing Network Codes and Implementation Guidance Documents related to emerging technologies integration in regulations. Also, the status of each Member State regarding their intention to integrate further regulations to achieve EU targets according to their published National and Energy Climate Plans is investigated and certain findings are presented.

Objective: Painful Hashimoto thyroiditis (HT) is a rare HT variant characterized by neck pain. The clinical differentiation between painful HT and subacute thyroiditis is challenging, as the diagnosis cannot be confirmed without histopathological evidence. Here we present a patient who had anterior neck pain who was diagnosed with HT. Methods: We present the patient's clinical examinations and laboratory findings (white blood cell count, thyroid-stimulating hormone, free thyroxine, thyroid peroxidase antibody, and erythrocyte sedimentation rate). Ultrasound images of the thyroid gland and pathology images representative of marked HT with positive IgG4 immunohistochemical stain after thyroidectomy are also presented. Results: A 42-year-old female with a 3-year history of HT developed recurrent anterior neck pain with bilateral radiation to the ears as well as a tender, enlarging thyroid goiter. She had no signs of fever or a preceding infection of the upper respiratory tract. Her pain was only temporarily alleviated by oral corticosteroids. According to the serial ultrasound records, both thyroid lobes decreased in size after 2 pain episodes. She eventually underwent total thyroidectomy and remained pain-free for 1.5 years, up to the last office follow-up visit. Histopathology confirmed the diagnosis of HT. Conclusion: In patients with HT, recurrent thyroid pain despite steroid treatment is the clinical hallmark of diagnosis of painful HT. The reference standard of diagnosis is pathology. Thyroidectomy may be considered after recurrent painful episodes.

Perfluorodicarbonyl (PFDC) compounds may be emitted directly into the atmosphere or formed in the atmospheric degradation of trace fluorinated gases, such as unsaturated perfluoro cyclic compounds. A potential atmospheric removal process for PFDCs is UV photolysis, which is presently not well-characterized. In this work, UV and infrared absorption spectra of FC(O)C(O)F, FC(O)CF

Biomass burning emissions, domestic- and wild-fires, agricultural burning, and fuel use, emit a blend of gases and particles with adverse effects on humans-health, climate and air quality. Furans are heterocyclic organic compounds (OVOC) that have been recently identified as important biomass burning emission-products. It is estimated that furan (C4H4O), 2-methylfuran (C5H6O), 2-furaldehyde (C5H4O2) and benzofuran (C8H6O) emission levels are 70 to 120 times higher compared to CO. Once furans are emitted in the atmosphere, they will undergo gas phase chemistry and, to an extent, they will be photolyzed at actinic wavelengths. OH and NO3 radicals, Cl atoms and O3 chemistry might result in tropospheric O3 and in secondary organic aerosols (SOA) formation, which might be enhanced due to their potent low volatility. Therefore, it is essential to investigate the kinetics and the mechanism of all the photochemically induced degradation pathways and identify and quantify SOA precursors, so as to evaluate their impact on Air-Quality and Climate. Within this framework, a thorough laboratory study, using two complementary techniques has been carried out. First, major atmospheric oxidants reaction rate coefficients with furans were determined. Secondly, the degradation mechanisms were investigated from both kinetic and conversion-yields perspectives. A Teflon atmospheric simulation chamber, named THALAMOS (THermALly regulated AtMOSpheric simulation chamber), was used to study the reactions at atmospheric pressure. State-of-the-art in-line instrumentation, e.g., FTIR spectroscopy and Chemical ionization mass spectrometry, were used for the real-time monitoring of reactants and products. To further our understanding, the reactions rate coefficients were also measured at 2 mTorr, between 253 and 363 K, with the continuous flow technique of the Very Low Pressure Reactor, in which an effusive molecular beam is analyzed with Quadrupole Mass Spectrometry (VLPR/QMS). Intercomparing the results from the two techniques reactions mechanistic-scheme was mapped-out and their impact was evaluated. OH and NO3 radicals and Cl atoms reactions with all the furans were measured to be in the order of 10-11, 10-10 and 10-12 cm3 molecule-1 s-1, respectively, leading to atmospheric-lifetimes between 2 and 10 hours. Temperature and pressure dependent kinetic measurements revealed association as the dominant reaction channel. However, experiments at very-low-pressure regime showed that HCl elimination cannot be excluded, especially when the furan-ring aromaticity is not breaking. Finally, it is evident that furans degradation will occur at low altitudes and SOA precursors, i.e., end-oxidation products will be formed nearby their emission locations. Further, kinetics studies were used to study the structure-reactivity trend of furans and to estimate their Photochemical Ozone Creation Potential (POCP). Results from this study are expected to significantly improve our insight on furans tropospheric photochemistry and via identifying and quantifying end-products and SOA formation, to assess their indirect and direct impact, on Climate, Air-Quality and humans-health.

Emphysematous gastritis (EG) is a rare and potentially lethal process caused by invasive, gas-producing bacteria leading to inflammation and gas dissection of the stomach. The most common etiologic agents are Clostridium infections, but other organisms, including enterobacteria, staphylococcus, and fungi have also been identified. We report the first case of EG due to Sarcina ventriculi in a solid organ transplant recipient, who presented with epigastric pain and vomiting. The patient had a history of type 1 diabetes mellitus (DM) with recurrent episodes of ketoacidosis and systemic diabetic complications, including severe gastroparesis. CT scan studies demonstrated EG with venous air, and endoscopy showed severe gastritis and ulcerations. In the gastric biopsies, abundant Sarcina ventriculi were noted in areas of mucosal/submucosal necrosis. Antibiotic treatment was instituted at admission, and subsequent endoscopy demonstrated the disappearance of Sarcina, with some improvement of the gastric inflammation; however, the patient developed septic shock with multiorgan failure and expired. This case highlights the need to consider other infectious etiologies in transplant patients, in addition to the well-known opportunistic infections.

Pathological evaluation of whole pancreas transplants (WPnTx) is necessary for the accurate determination of the cause of graft dysfunction, graft failure, and graft insufficiency. In the early posttransplantation period, histological studies are essential to differentiate idiopathic graft thrombosis from thrombosis secondary to acute allograft rejection, most likely representing an aggressive form of antibody-mediated rejection (ABMR). Clinical manifestations of graft dysfunction have overall poor specificity. Histological studies are necessary to differentiate acute rejection from other causes of graft injury and are furthermore required to differentiate acute T-cell-mediated rejection (TCMR) from ABMR, which are treated differently. Equally important is the accurate identification of the various types of islet cell pathology, including calcineurin inhibitor toxicity and development of recurrent type 1 diabetes mellitus. Histological studies are also shedding light on the contribution of type 2 diabetes mellitus to graft dysfunction/insufficiency. This chapter includes a discussion of the Banff grading schema, as well as the various nonrejection-related pathological processes affecting WPnTx. In addition, the contribution of pathological evaluation in various other clinicopathological settings is presented.

Shear-wave splitting analysis of local earthquakes is a challenge tackled by a long history of published software. However, there is currently no complete solution that integrates manual and (partially or fully) automatic methods. The Pytheas software aims to achieve this by offering a collection of popular analysis techniques accompanied by an intuitive Graphical User Interface. The software offers its own implementation of the following methods: (a) Visual inspection of polarigrams and hodograms (manual), (b) Rotation-Correlation (semi-automatic), (c) Eigenvalue (semi-automatic) and (d) Minimum Energy (semi-automatic). Moreover, it automates the last three operations by using Cluster Analysis. The software also utilizes databases to effectively manage results storing. It is compatible with standard file formats for event and station metadata (QuakeML and StationXML), as well as waveform data (such as SAC and miniSEED). Pytheas also introduces a novel algorithm for automatically assigning quality grades to measurements. To showcase the utility of the software, we analyzed a set of 263 events recorded in the Western Gulf of Corinth (Greece). The workflow included the establishment of a control group through manual analysis, the fully automatic processing of the catalogue and the verification of the results through visual inspection of a sample. Automatic and manual measurements show good agreement, validating the potential of Cluster Analysis. The presented software aims to provide a friendly experience to the end-user in all stages of its usage (installation, operation and database management) and trivialize the time-consuming part of a local shear-wave splitting study, leaving more time for interpretation and analysis of results. © 2019 Elsevier Ltd