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414 results on '"C. Milanese"'

1. Paracetamol (acetaminophen) rescues cognitive decline, neuroinflammation and cytoskeletal alterations in a model of post-operative cognitive decline (POCD) in middle-aged rats

Author

B. Garrone, L. Durando, J. Prenderville, E. Sokolowska, C. Milanese, F. P. Di Giorgio, C. Callaghan, and M. Bianchi

Subjects
Medicine, Science
Abstract

Abstract Post-operative cognitive dysfunction (POCD) is a debilitating clinical phenomenon in elderly patients. Management of pain in elderly is complicated because analgesic opiates elicit major side effects. In contrast, paracetamol (acetaminophen) has shown analgesic efficacy, no impact on cognition, and its side effects are well tolerated. We investigated the efficacy of paracetamol, compared to the opioid analgesic buprenorphine, in a model of POCD by investigating cognitive decline, allodynia, peripheral and hippocampal cytokines levels, and hippocampal microtubule dynamics as a key modulator of synaptic plasticity. A POCD model was developed in middle-aged (MA) rats by inducing a tibia fracture via orthopaedic surgery. Control MA rats did not undergo any surgery and only received isoflurane anaesthesia. We demonstrated that cognitive decline and increased allodynia following surgery was prevented in paracetamol-treated animals, but not in animals which were exposed to anesthesia alone or underwent the surgery and received buprenorphine. Behavioral alterations were associated with different peripheral cytokine changes between buprenorphine and paracetamol treated animals. Buprenorphine showed no central effects, while paracetamol showed modulatory effects on hippocampal cytokines and markers of microtubule dynamics which were suggestive of neuroprotection. Our data provide the first experimental evidence corroborating the use of paracetamol as first-choice analgesic in POCD.

Published
2021
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2. THE EFFECTS OF THREE DIFFERENT REAR KNEE ANGLES ON KINEMATICS IN THE SPRINT START

Author

C. Milanese, M. Bertucco, and C. Zancanaro

Subjects
block velocity, motion analysis, set position, sprint techniquea, Sports medicine, RC1200-1245, Biology (General), QH301-705.5
Abstract

The purpose of this study was to investigate the rear knee angle range in the set position that allows sprinters to reach greater propulsion on the rear block during the sprint start. Eleven university-track team sprinters performed the sprint start using three rear knee angle conditions: 90°, 115° and 135°. A motion capture system consisting of 8 digital cameras (250 Hz) was used to record kinematic parameters at the starting block phase and the acceleration phase. The following variables were considered: horizontal velocity of the centre of mass (COM), COM height, block time, pushing time on the rear block, percentage of pushing time on the rear block, force impulse, push-off angle and length of the first two strides. The main results show that first, horizontal block velocity is significantly greater at 90° vs 115° and 135° rear knee angle (p

Published
2014
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3. Modeling the kinetic behavior of the Li-RHC system for energy hydrogen storage: (I) absorption

Author

A. M. Neves, J. Puszkiel, G. Capurso, J.M. Bellosta von Colbe, C. Milanese, M. Dornheim, T. Klassen, and J. Jepsen

Subjects
Metal Hydride, Reactive Hydride Composite, Hydrogen Storage, Kinetic Modeling, borohydrides
Abstract

The Lithium–Boron Reactive Hydride Composite System (Li-RHC) (2 LiH+MgB2/2 LiBH4+MgH2) is a high-temperaturehydrogen storage materialsuitable forenergy storage applications. Herein, a comprehensive gas-solidkinetic modelfor hydrogenation is developed. Based on thermodynamic measurements under absorption conditions, the system's enthalpy ΔH and entropy ΔS are determined to amount to −34±2kJ∙mol H2−1and −70±3J∙K−1∙mol H2−1, respectively. Based on thethermodynamic behaviorassessment, the kinetic measurements' conditions are set in the range between 325°C and 412°C, as well as between 15bar and 50bar. Thekinetic analysisshows that the hydrogenation rate-limiting-step is related to a one-dimensional interface-controlled reaction with a driving-force-correctedapparent activation energyof 146±3kJ∙mol H2−1. Applying the kinetic model, the dependence of the reaction rate constant as a function of pressure and temperature is calculated, allowing the design of optimized hydrogen/energy storage vesselsviafinite element method(FEM) simulations.

Published
2021
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5. The effect of intrinsic defects on garnet scintillator performance

Author

Kenneth J. McClellan, M. R. Levy, C. Milanese, Robin W. Grimes, and Christopher R. Stanek

Subjects
Physics, Nuclear and High Energy Physics, Scintillation, Yield (engineering), business.industry, Detector, Electron, Scintillator, Crystallographic defect, Atomic units, Impurity, Optoelectronics, business, Instrumentation
Abstract

In order to enhance capabilities for the reliable detection of nuclear material, improved detector materials are required. There is considerable room for improvement within the scintillator family of materials. However, native defects are present in all materials and impurities are similarly common. In scintillators, these defects serve as trap sites for electrons or holes, and therefore may contribute to decreased and delayed light yield. In fact, Lempicki and Bartram [J. Lumin. 81 (1999) 13] have proposed that understanding defect related phenomena is vital to the improvement of scintillators. It follows that if the most egregious electron/hole trapping defects are removed from the system, light output should increase. However, defect removal is difficult to achieve since often the defect-type to be removed is not known. In this paper, we assist the optimization of scintillators by employing atomic scale simulation techniques to predict the intrinsic defect structure of RE 3 Al 5 O 12 garnets (where RE ranges from Lu to Gd and Y). Specifically, we predict cation antisite defects to be the lowest energy intrinsic defect. Furthermore, we describe how our results can be used to interpret experimental observations.

Published
2007
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6. α-Glycerylphosphorylethanolamine rescues astrocytes from mitochondrial impairment and oxidative stress induced by amyloid β-peptides

Author

Claudio Russo, F. Mancini, M. Bisaglia, Valentina Venezia, C. Milanese, M Biglieri, and Gennaro Schettini

Subjects
Membrane Fluidity, Tetrazolium Salts, Biology, Mitochondrion, medicine.disease_cause, Membrane Potentials, Lipid peroxidation, Cellular and Molecular Neuroscience, chemistry.chemical_compound, medicine, Membrane fluidity, Animals, Gliosis, Inner mitochondrial membrane, Cells, Cultured, Amyloid beta-Peptides, Microscopy, Confocal, Phosphatidylethanolamines, Cell Membrane, Neurodegeneration, Cell Biology, medicine.disease, Peptide Fragments, Mitochondria, Rats, Cell biology, Oxidative Stress, Thiazoles, medicine.anatomical_structure, chemistry, Biochemistry, Astrocytes, Nerve Degeneration, Neuroglia, Lipid Peroxidation, medicine.symptom, Oxidative stress
Abstract

The present work shows that alpha-glycerylphosphorylethanolamine (alpha-GPE) is effective in recovering astrocytes from mitochondrial membrane integrity and potential derangement and cellular oxidative stress that occur under amyloid beta-peptides-induced reactive gliosis.alpha-Glycerylphosphorylethanolamine (alpha-GPE), a new compound with nootropic properties, known to improve in vivo the learning and memory processes, has been tested for its protective properties on an in vitro model of degeneration. Rat primary astrocytic cultures treated with two amyloid-derived peptides, Abeta((1-40)) and Abeta(3(pE)-42), showed a marked reduction of the mitochondrial redox activity and membrane potential, together with an increase of oxidative species production. Plasma membrane lipid peroxidation (LPO) as well as generation of peroxides is greatly increased under Abeta-peptides toxicity. These features, typical of the reactive gliosis that accompanies neuronal degeneration, were readily recovered by pretreatment with alpha-GPE. alpha-GPE, likely improving the fluidity of cell membrane, has the potential to recover astrocytes from the general redox derangement induced by different amyloid fragments and possibly to protect from inflammation, gliosis and neurodegeneration. This is the first evidence of an antioxidant effect of the ethanolamine derivative on a rat model of chronic gliosis.

Published
2004
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8. Multiple sclerosis in twins from continental Italy and Sardinia: a nationwide study

Author

Ristori G, Cannoni S, Stazi MA, Vanacore N, Cotichini R, Alfo M, Pugliatti M, Sotgiu S, Solaro C, Bomprezzi R, Di Giovanni S, Figa` Talamanca L, Nistico L, Fagnani C, Neale MC, Cascino I, Giorgi G, Battaglia MA, Buttinelli C, Tosi R, Salvetti M, M. Melato, R. Dellantonio, L. Sironi, E. Bottacchi, M. Signorino, R. Angeloni, L. Curatola, C. Paci, M. Ragno, G. Sirocchi, AM. Vurchio, E. Duc, D. Spitaleri, M. Trojano, M. Liguori, N. Cimini, G. Moretto, M. Porta, MR Rottoli A. Mamoli, M. Camerlingo, E. Nardozza, T. Sacquegna, S. Stecchi, C. Scandellari, L. Callea, R. Capra, M. Codella, M. G. Marrosu, E. Cocco, A. Spissu, G. Cossu, S. Tronci, A. Di Lauro, E. Lombardi, A. Reggio, F. Patti, P. Valentino, A. Quattrone, D Farina, M. E. Nives, A. Lugaresi, F. Perla, M. G. Rosso, M. R. Tola, E. Granieri, MP Amato L. Massacesi, E. Millefiorini, V. Durastanti, G. L. Mancardi, A. Murialdo, NR. Pizio, P. Bellantonio, R. Fantozzi, R. Totaro, A. Carolei, F. Giramma, A. T. Lazzaro, C. Giraldi, M. Mazzoni, G. Giuliani, E. Pucci, P. Previdi, MC. Fazio, M. Buccafusca, P. Girlanda, C. Messina, G. D’Aleo, C. Milanese, L. Lamantia, D. Caputo, E. Scarpini, R. Clerici, L. Moiola, M. Gironi, E. Merelli, F. Casoni, S. Bonavita, G. Tedeschi, M. Leone, D. Mittino, SB. Murgia, L. Musu, P. Gallo, P. Perini, E. Frasson, G. Salemi, G. Cuccia, E. Montanari, L. Manneschi, D. Saviola, M. Antonelli, V. Cosi, R. Bergamaschi, V. Gallai, D. Murasecco, P. Sarchielli, R. Urcioli, G. Perticoni, G. Meucci, G. Moscato, B. Lucci, E. Covezzi, MG. Coniglio, D. Acquistapace, L. Motti, B. Dossi Curro`, M. Frontoni, C. Mainero, P. Giannetti, I. Pestalozza, S. Di Legge, M. Spadaro, C. Pozzilli, S. Romano, B. Mercuri, C. Scoppetta, C. Gasperini, S. Galgani, MG. Grasso, S. Paolucci, PA. Tonali, A. Leonardi, A. Oneto, G Rosati, M. A. Sotgiu, A. Bertolotto, M. Capobianco, L. Durelli, M. Clerico, L. Sosso, R. Bongioanni, D. Orrico, C. Carbonin, U. Freo. M. Zaffaroni, A. Ghezzi, N. Falcone, Ristori G, Cannoni S, Stazi MA, Vanacore N, Cotichini R, Alfo M, Pugliatti M, Sotgiu S, Solaro C, Bomprezzi R, Di Giovanni S, Figa` Talamanca L, Nistico L, Fagnani C, Neale MC, Cascino I, Giorgi G, Battaglia MA, Buttinelli C, Tosi R, Salvetti M, M. Melato, R. Dellantonio, L.Sironi, E. Bottacchi, M. Signorino, R. Angeloni, L. Curatola, C. Paci, M. Ragno, G. Sirocchi, AM. Vurchio, E. Duc, D. Spitaleri, M. Trojano, M. Liguori, N. Cimini, G. Moretto, M. Porta, MR Rottoli A. Mamoli, M. Camerlingo, E. Nardozza, T. Sacquegna, S. Stecchi, C. Scandellari, L. Callea, R. Capra, M. Codella, M. G. Marrosu, E. Cocco, A. Spissu, G. Cossu, S. Tronci, A. Di Lauro, E. Lombardi, A. Reggio, F. Patti, P. Valentino, A. Quattrone, D Farina, M. E. Nives, A. Lugaresi, F. Perla, M. G. Rosso, M.R. Tola, E. Granieri, MP Amato L. Massacesi, E. Millefiorini, V. Durastanti, G. L. Mancardi, A. Murialdo, NR. Pizio, P. Bellantonio, R. Fantozzi, R. Totaro, A. Carolei, F. Giramma, A. T. Lazzaro, C. Giraldi, M. Mazzoni, G. Giuliani, E. Pucci, P. Previdi, MC. Fazio, M. Buccafusca, P. Girlanda, C. Messina, G. D’Aleo, C. Milanese, L. Lamantia, D. Caputo, E. Scarpini, R. Clerici, L. Moiola, M. Gironi, E. Merelli, F. Casoni, S. Bonavita, G. Tedeschi, M. Leone, D. Mittino, SB. Murgia, L. Musu, P. Gallo, P. Perini, E. Frasson, G. Salemi, G. Cuccia, E. Montanari, L. Manneschi, D. Saviola, M. Antonelli, V. Cosi, R. Bergamaschi, V. Gallai, D. Murasecco, P. Sarchielli, R. Urcioli, G. Perticoni, G. Meucci, G. Moscato, B. Lucci, E. Covezzi, MG. Coniglio, D. Acquistapace, L. Motti, B. Dossi Curro`, M. Frontoni, C. Mainero, P. Giannetti, I. Pestalozza, S. Di Legge, M. Spadaro, C. Pozzilli, S. Romano, B. Mercuri, C. Scoppetta, C. Gasperini, S. Galgani, MG. Grasso, S. Paolucci, PA. Tonali, A. Leonardi, A. Oneto, and G Rosati, M. A. Sotgiu, A. Bertolotto, M. Capobianco, L. Durelli, M. Clerico, L. Sosso, R. Bongioanni, D. Orrico, C. Carbonin, U. Freo. M. Zaffaroni, A. Ghezzi, N. Falcone

Subjects
Male, Questionnaires, Multiple Sclerosis, Concordance, Population, Twins, Dizygotic twins, Disease cause, Multiple Sclerosis, Epidemiology, Twins, Cohort Studies, Cohort Studies, Disease Susceptibility, Female, Genetic Predisposition to Disease, Humans, Italy, epidemiology, Male, Multiple Sclerosis, epidemiology/genetics, Questionnaires, Regression Analysis, Twins, Surveys and Questionnaires, medicine, Humans, Genetic Predisposition to Disease, education, education.field_of_study, epidemiology/genetics, business.industry, Multiple sclerosis, medicine.disease, Penetrance, Twin study, Confidence interval, Neurology, Italy, Regression Analysis, Settore MED/26 - Neurologia, Female, epidemiology, Neurology (clinical), Disease Susceptibility, business, Demography
Abstract

Knowledge about the balance between heritable and nonheritable risk in multiple sclerosis (MS) is based on twin studies in high-prevalence areas. In a study that avoided ascertainment limitations and directly compared continental Italy (medium-prevalence) and Sardinia (high-prevalence), we ascertained 216 pairs from 34,549 patients. This gives a twinning rate of 0.62% among MS patients, significantly less than that of the general population. In continental Italy, probandwise concordance was 14.5% (95% confidence interval, 5.1-23.8) for monozygotic and 4.0% (95% confidence interval, 0.8-7.1) for dizygotic twins. Results in Sardinia resemble those in northern populations but in limited numbers. Monozygotic concordance was 22.2% (95% confidence interval, 0-49.3) probandwise, but no concordant dizygotic pairs were identified. A questionnaire on 80 items possibly related to disease cause was administered to 70 twin pairs, 135 sporadic patients, and 135 healthy volunteers. Variables positively (7) or negatively (2) associated with predisposition and concordance in twins largely overlapped and were mainly linked to infection. If compared with previous studies, our data demonstrate that penetrance in twins appears to correlate with MS prevalence. They highlight the relevance of nonheritable variables in Mediterranean areas. The apparent underrepresentation of MS among Italian twins draws attention to protective factors, shared by twins, that may influence susceptibility.

Published
2006
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10. New insights on trazodone effect in promoting neuronal differentiation of adult murine hippocampal neural progenitor cells

Author

Mariagrazia Grilli, L. Polenzani, C. Milanese, G. Mangano, V. Bortolotto, Serena Tongiani, F. Garofolo, and F. Mancini

Subjects
Pharmacology, Neuronal differentiation, Trazodone, Biology, Hippocampal formation, Neural stem cell, Psychiatry and Mental health, Neurology, medicine, Pharmacology (medical), Neurology (clinical), Neuroscience, Biological Psychiatry, medicine.drug
Published
2016
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11. Fourth meeting of the European Neurological Society 25–29 June 1994 Barcelona, Spain

Author

H. Hattig, C. Delli Pizzi, M. C. Addonizio, Michelle Davis, A. R. Giovagnoli, L. Florensa, M. Roth, J. de Kruijk, Francisco Lacruz, Ph. Dewailly, A. Toygar, C. Avendano, P.P. De Deyn, J. F. Hurtevent, F. Lomeila, T. W. Wong, Gordon T. Plant, M. Bud, H. J. Willison, DH Miller, D. W. Langdon, R. Cioni, J. Servan, A. Kaygisiz, E. Racadot, D. B. Schens, E. Picciola, L. Falip, C. Bouchard, J. Jotova, A. Jorge-Santamaria, P. Misra, A. Dufour, C. P. Panagopoulos, A. Venneri, B. Sredni, B. Angelard, M. Janelidze, M. Carreno, J. Obenberger, J. Pouget, H. W. Moser, R. Kaufmann, J. A. Molina, D. Linden, A. Martin Urda, E. Uvestad, A. Krone, J. P. Cochin, J. Mallecourt, A. Cambon-Thomsen, K. Violleau, P. Osschmann, A. M. Durocher, E. Bussaglia, D. M. Danielle, H. Efendi, C. Van Broeckhoven, K. G. Jordan, W. Rautenberg, C. Iniguez, J. M. Delgado, Graham Watson, M. Lawden, Gareth J. Barker, K. Stiasny, James T. Becker, G. Campanella, E. Peghi, A. Poli, A. Haddad, T. Yamawaki, Giacomo P. Comi, S. Sotgiu, B. Ersmark, A. Pomes, M. Ziegler, P. Ferrante, P. Ruppi, H. KuÇukoglu, R. Bouton, U. K. Rinne, P. Vieregge, M. Dary, P. Giunti, Peter J. Goadsby, S. Jung, E. Secor, A. Steinberg, N. Vila, M. A. Hernandez, M. Cursi, A. Enqelhardt, A. Engelhardt, J. Veitch, F. Di Silverio, F. Arnaud, B. Neundörfer, R. Brucher, Dominique Caparros-Lefebvre, B. Meyer, Marianne Dieterich, M. H. Snidaro, R. Gomez, R. Cerbo, M. Ragno, J. M. Vance, S. Nemni, A. Caliskan, F. Barros, I. Velcheva, D. Ceballos-Baumann, V. Barak, A. Avila, N. Antonova, F. Resche, S. Pappata, L. Varela, S. R. Silveira Santos, A. Cammarota, L. Naccache, Y. Nara, E. Tournier-Lasserves, R. Mobner, T. Chase, A. Ensenyat, J. Ulrich, G. Giegerich, M. Rother, M. Revilla, N. Nitschke, K. Honczarenko, E. Basart Tarrats, J. Blin, B. Jacob, J. Santamaria, S. Knezevic, J. L. Castillo, M. Antem, J. Colomer, O. Busse, Didier Hannequin, S. Carrier, J. B. Ruidavets, C. Rozman, J. Bogoussslavsky, J. Pascual Calvet, E. Monros, J. M. Polo, M. Zucconl, Javier Muruzabal, R. R. Allen, R. Rivolta, K. Haugaard, A. Nespolo, K. Hoang-Xuang, G. Bussone, T. Avramidis, E. Corsini, Christiana Franke, T. Vinogradova, H. Boot, K. Vestergaard, G. H. Jansen, N. Argentino, M. Raltzig, W. Linssen, Mark B. Pepys, P. Roblot, L. Lauritzen, E. Fainardi, D. Morin, T. X. Arbizu Urdiain, J. Wollenhaupt, S. Bostantjopoulou, G. Pavesi, A. D. Forman, Giovanni Fabbrini, D. Jean, J. J. Archelos, M. I. Blanchs, M. Del Gobbo, Anna Carla Turconi, Ch. Derouesné, Elio Scarpini, A. Visbeck, P. Castejon, J. P. Renou, F. Mounier-Vehier, G. Potagas, Ch. Duyckaerts, A. Filla, R. Schneider, G. Ronen, K. Nagata, J. P. Vedel, A. Henneberg, G. van Melle, C. Baratti, H. Knott, M. C. Prevett, A. Bes, B. Metin, Jos V. Reempts, L. Martorell, Mefkure Eraksoy, H. O. Handwerker, D. S. Younger, O. Oktem, D. Frongillo, C. Soriano-Soriano, L. Niehaus, F. Zipp, A. Tartaro, S Newman, R. H. Browne, P. Davous, R. Sanchez, M. Muros, M. E. Kornhuber, A. Lavarone, M. Mohr, M. R. Garcia, S. Russell, H. Kellar-Wood, M. R. Tola, B. Ostermeyer, Ch. Tzekov, K. Sartor, E. B. Ringelstein, P. P. Gazzaniga, Paul Krack, H. Fidaner, H. Rico, T. Dbaiss, F. Alameda, E. Torchiana, L. Rumbach, I. Charques, J. M. Bogaard, C. D. Frith, L. J. Rappelle, R. Brenner, A. Joutel, K. Fuxe, G. HÄcker, M. J. Blaser, J. Valls-SolÇ, G. Ulm, M. Alberdi, A. Bock, F. W. Bertelsmann, U. Wieshmann, J. Visa, J. R. Lupski, D. D'Amico, L. M. P. Ramos, A. A. Vanderbark, R. Horn, M. Warmuth, Dietmar Kühne, Mark S. Palmer, C. Ehrenheim, E. Canga, S. Viola, O. Scarpino, P. Naldi, R. Almeida, A. A. Raymond, J. Gamez, Stephan Arnold, A. DiGiovanni, J. Dalmau, C. C. Chari, H. F. Beer, J. C. Koetsier, J. Iriarte, E. Yunis, J. Casadevall, E. Le Guern, E. Stenager, S. R. Benbadis, J. M. Warter, F. Burklin, I. Theodorou, L. Johannesen, G. A. Graveland, X. Leclerc, I. Vecchio, L. Ozelius, G. Nicoletti, R. K. Gherardi, E. Esperet, M. L. Delodovici, F. Cattin, F. Paiau, Giorgio Sacilotto, C. A. J. Broere, D. Chavdarov, J. P. Willmer, C. H. Hawkes, Th. Naegele, E. Ellie, E. Dartigues, M. J. Guardiola, S. Hesse, Z. Levic, Marco Rovaris, P. Saugeir-Veber, B. A. Yaqub, H. F. Durwen, R. Larumbe, J. Ballabrina, M. Sendtner, J. Röther, M. Horstink, C. Kluglein, M.P. Montesi, H. Apaydin, J. Montoya, E. Waubant, Ch. Verellen-Dunoulin, A. Nicolai, J. Lopez-Delval, R. Lemon, G. Cantinho, E. Granieri, A. Zeviani, Wolfgang H. Oertel, U. Ficola, V. Di Piero, V. Fragola, K. Sabev, M. V. Guitera, I. Turki, F. Bolgert, P. Ingrand, J. M. Gobernado, L. M. E. Grimaldi, S. Baybas, B. Eymard, Y. Rolland, Y. Robitaille, Ta. Pampols, P. J. Koehler, A. Carroacedo, J. Vilchez, S. Di Vittorio, I. R. Rise, T. Nagy, M. Kuffner, E. Palazzini, A. Ott, J. Pruim, T. X. Arbizu, E. Manetti, C. Cervera, S. Felber, G. Gursoy, J. Scholz, G. A. Buscaino, M. S. Chen, A. Pascual, J. Hazan, J. U. Gajda, J. G. Cea, G. Bottini, G. Damalik, F. Le Doze, G. Bonaldi, J. M. Hew, C. Messina, A. M. Kennedy, J. M. Carney, N. M. F. Murray, M. Parent, M. Koepp, V. Dimova, D. De Leo, K. Jellinger, G. Salemi, S. Mientus, M. L. Hansen, F. Mazzucchelli, J. Vieth, M. Mauri, E. Bartels, L. Johannsen, C. Humphreys, J. Emile, D. N. Landon, E. Kansu, R. Sanchez-Pernaute, Rsj Frackowiak, M. Gonzalez Torres, L. Oller, C. Machedo, J. Kother, M. Billiard, H. Durak, T. Schindler, A. Frank, A. Uncini, A. Sbriccoli, C. Farinas, D. W. Paty, N. Fast, A. T. Zangaladze, A. Kerkhofs, J. M. Pino Garcia, I. De la Fuente, B. Marini, L. Gomez, I. Rubio, Alessandra Bardoni, C. Brodie, P. Acin, U. Sliwka, S. A. Hawkins, S. Tardieu, F. Vitullo, J. M. Pereira Monteino, R. Gagliardi, T. Jezewski, A. Cano, T. Lempert, F. Abad Alegria, G. Rotondo, D. Ince, C. Martinez Parra, Y. Huang, H. Luders, Y. Steinvil, F. G. A. Van Der Meche, R. Bianchi, A. Sanchez, T. Sevilla, J. M. Ketelslegers, A. Domzal-Stryga, M. Pandolfo, M. O. Josse, K. W. Neff, I. Blanco, G. W. Bruyn, O. W. Witte, J. L. Thibault, G. Andersen, J. Pariset, A. Marcone, R. J. M. Lane, A. Hofman, M. Verin, T. Matilla, P. Bedoucha, J. Roche, M. Lai, M. Collard, A. Ugarte, F. Gallecho, D. Silbersweig, C. Kennard, J. P. Azulay, T. W. Ho, P. L. I. Dellemijn, R. Girardello, F. Baas, B. Voss, F. Rozenberg, E. M. Brocker, V. Stanev, A. A. J. Soeterboek, A. Marra, A. Rey, E. Ertem, M. Sawradewicz-Rybak, J. De Keyser, P. Cavallari, F. Proust, Y. Chevalier, H. C. Hansen, D. Leys, C. A. Davie, K. Hoang-Xuan, C. Bairati, H. van Crevel, Thomas T. Warner, B. Bompais, A. Dobbeleir, T Campbell, C. Macko, C. J. M. Klijn, M. Dussallant, T. P. Berlit, W. Rozenbaum, M. J. van den Bent, W. A. Rocca, M. Muller, H. Hundemer, U. Zifko, M. Campera, F. Drislane, D. Ranoux, T. M. Kloss, Anil Kumar, I. Ruolt, C. Bargnani, B. Marescau, N. A. Losseff, S. Notermans, B. Kint, E. T. Burke, C. Aykut, J. Matias Guiu, P. Maquet, T. Drogendijk, M. Leone, K. von Ammon, M. Pepeliarska, C. Prados, L. DiGiamberardino, T. Logtenberg, G. Lenoir, I. Castaldo, Damhaut, M. Radionova, G. Sirabian, R. 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Frigo, Leif Østergaard, J. L. Munoz Blanco, A. Cruz-Matinez, J. De Reuck, C. Theillet, T. Barroso, V. Oikonen, Florence Lebert, M. Kilinc, C. Cordon-Cardon, G. Stoll, E. Thiery, F. Pulcinelli, J. Solski, M. Schmiegelow, L. J. Polman, P. Fernandez-Calle, C. Wikkelso, M. Ben Hamida, M. Laska, E. Kott, W. Sulkowski, C. Lucas, N. M. Bornstein, D. Schmitz, M. W. Lammers, A. de Louw, R. J. S. Wise, P. A. van Darn, C. Antozzi, P. Villanueva, P. H. E. Hilkens, C. Constantin, W. Ricart, A. Wolf, M. Gamba, P. Maguire, Alessandro Padovani, B. M. Patten, Marie Sarazin, H. Ackermann, L. Durelli, S. Timsit, Sebastian Jander, B. W. Scheithauer, G. Demir, J. P. Neau, P. Barbanti, A. Brand, N. AraÇ, V. Fischer-Gagnepain, R. Marchioli, G. Serratrice, C. Maugard-Louboutin, G. T. Spencer, D. Lücke, G. Mainardi, K. Harmant Van Rijckevorsel, G. B. Creel, R. Manzanares, Francesco Fortunato, A. May, J. Workman, K. Johkura, E. Fernandez, Carlo Colosimo, L. Calliauw, L. Bet, Félix F. Cruz-Sánchez, M. Dhib, H. Meinardi, F. Carrara, J. Kuehnen, C. Peiro, H. Lassmann, K. Skovgaard Olsen, A. McDonald, L. Sciulli, A. Cobo, A. Monticelli, B. Conrad, J. Bagunya, J. Benitez, V. Desnizza, B. Dupont, O. Delrieu, D. Moraes, J. J. Heimans, F. Garcia Rio, M. Matsumto, A. Fernandez, R. Nermni, R. Chalmers, M. J. Marchau, F. Aguado, P. Velupillai, P. J. Martin, P. Tassan, V. Demarin, A. Engelien, T. Gerriets, Comar, J. L. Carrasco, J. P. Pruvo, A. Lopez de Munain, D. Pavitt, J. Alarcon, Chris H. Polman, B. Guldin, N. Yeni, Hartmut Brückmann, N. Wilczak, H. Szwed, R. Causaran, G. Kyriazis, M. E. Westarp, M. Gasparini, N. Pecora, J. M. Roda, E. Lang, V. Scaioli, David R. Fish, D. Caputo, O. Gratzl, R. Mercelis, A. Perretti, G. Steimetz, I. Link, C. Rigoletto, A. Catafau, G. Lucotte, M. Buti, G. Fagiolari, A. Piqueras, C. Godinot, J. C. Meurice, Erodriguez J. Dominigo, F. Lionnet, H. Grzelec, David J. Brooks, P. M. G. Munro, F. X. Weilbach, M. Maiwald, W. Split, B. Widjaja-Cramer, V. Ozturk, J. Colas, E. Brizioli, J. Calleja, L. Publio, M. Desi, R. Soffietti, P. Cortinovis-Tourniaire, E. F. Gonano, G. Cavaletti, S. Uselli, K. Westerlind, H. Betuel, C. O. Dhiver, H. Guggenheim, M. Hamon, R. Fazio, P. Lehikoinen, A. Esser, B. Sadzot, G. Fink, Angelo Antonini, D. Bendahan, V. Di Carlo, G. Galardi, A. F. Boller, M. Aksenova, Del Fiore, V. de la Sayette, H. Chabriat, A. Nicoletti, A. Dilouya, M. L. Harpin, E. Rouillet, J. Stam, A. Wolters, M. R. Delgado, Eduardo Tolosa, G. Said, A. J. Lees, L. Rinaldi, A. Schulze-Bonhage, MA Ron, C. Lefebvre, E. W. Radü, R. Alvarez, M. L. Bots, P. Reganati, S. Palazzi, A. Poggi, N. J. Scolding, V. Sazdovitch, T. Moreau, E. Maes, M. A. Estelies, P. Petkova, Jose-Felix Marti-Masso, G De La Meilleure, N. Mullatti, M. Rodegher, N. C. Notermans, T. A. T. Warner, S. Aktan, J. P. Louboutin, L. Volpe, C. Scheidt, W. Aust, C. M. Wiles, U. Schneider, S. K. Braekken, W. R. Willems, K. Usuku, Peter M. Rothwell, C. Talamon, M. L. Sacchetti, A. Codina, M. H. Marion, A. Santoro, J. Roda, A. Bordoni, D. J. Taylor, S. Ertas, H. H. Emmen, J. Vichez, V. BesanÇon, R. E. Passingham, M. L. Malosio, A. Vérier, M. Bamberg, A. W. Hansen, E. Mostacero, G. Gaudriault, Marie Vidailhet, B. Birebent, K. Strijckmans, F. Giannini, T. Kammer, I. Araujo, J. Nowicki, E. Nikolov, A. Hutzelmann, R. Gherardi, J. Verroust, L. Austoni, A. Scheller, A. Vazquez, S. Matheron, H. Holthausen, J. M. Gerard, M. Bataillard, S. Dethy, V. H. Patterson, V. Ivanez, N. P. Hirsch, F. Ozer, M. Sutter, C. Jacomet, M. Mora, Bruno Colombo, A. Sarropoulos, T. H. Papapetropoulos, M. Schwarz, D. S. Dinner, N. Acarin, B. Iandolo, J. O. Riis, P. R. J. Barnes, F. Taroni, J. Kazenwadel, L. Torre, A. Lugaresi, I. L. Henriques, S. Pauli, S. Alfonso, Pedro Quesada, A. S. T. Planting, J. M. Castilla, Thomas Gasser, M. Van der Linden, A. Alfaro, E. Nobile-Orazio, G. Popova, W. Vaalburg, F. G. A. van der Mech, L. Williams, F. Medina, J. P. Vernant, J. Yaouanq, B. Storch-Hagenlocher, A. Potemkowski, R. Riva, M. H. Mahagne, M. Ozturk, Ve. Drory, N. Konic, C. Jungreis, A. Pou Serradell, J. L. Gauvrit, G. J. Chelune, S. Hermandez, T. Dingus, L. Hewer, Ch. Koch, M. N. Metz-Lutz, G. Parlato, M. Sinaki, Charles Pierrot-Deseilligny, H. C. Diener, J. Broeckx, J. Weill-Fulazza, M. L. Villar, M. Rizzo, O. Ganslandt, C. Duran, N. A. Fletcher, G. Di Giovacchino, Susan T. Iannaccone, C. Kolig, N. Fabre, H. A. Crockard, Rita Bella, M. Tazir, E. Papagiannuli, K. Overgaard, Emma Ciafaloni, I. Lorenzetti, F. Viader, P. A. H. Millac, I. Montiel, L. H. Visser, M. Palomar, P. L. Murgia, H. Pedersen, Rafael Blesa, S. Seddigh, W. O. Renier, I. Lemahieu, H. M. L. Jansen, L. Rosin, J. Galofre, K. Mattos, M. Pondal, G. M. Hadjigeorgiou, D. Francis, L. Cantin, D. Stegeman, M. Rango, A. B. M. F. Karim, S. Schraff, B. Castellotti, I. Iriarte, E. Laborde, T. J. Tjan, R. Mutani, D. Toni, B. Bergaasco, J. G. Young, C. Klotzsch, A. Zincone, X. Ducrocq, M. Uchuya, O. J. Kolar, A. Quattrone, T. Bauermann, Nereo Bresolin, J. Vallée, B. C. Jacobs, A. Campos, Werner Poewe, J. A. Villanueva, A. W. Kornhuber, A. Malafosse, E. Diez-Tejedor, G. Jungreia, M. J. A. Puchner, A. Komiyama, O. Saribas, V. Volpini, L. Geremia, S. Bressi, A. Nibbio, Timothy E. Bates, T. z. Tzonev, E. Ideman, G. A. Damlacik, G. Martino, G. Crepaldi, T. Martino, Kjell Någren, E. Idiman, D. Samuel, J. M. Perez Trullen, Y. van der Graaf, J. O. Thorell, M. J. M. Dupuis, E. Sieber, R. D'Alessandro, C. Cazzaniga, J. Faiss, A. Tanguy, A. Schick, I. Hoksergen, A. Cardozo, R. Shakarishvili, G. K. Wennlng, J. L. Marti-Vilalta, J. Weissenbach, I. L. Simone, Amalia C. Bruni, Darius J. Adams, C. Weiller, A. Pietrangeli, F. Croria, C. Vigo-Pelfrey, Patricia Limousin, A. Ducros, G. Conti, O. Lindvall, E. Richter, M. Zuffi, A. Nappo, T. Riise, J. Wijdenes, M. J. Fernandez, J. Rosell, P. Vermersh, S. Servidei, M. S. C. Verdugo, F. Gouttiere, W. Solbach, M. Malbezin, I. S. Watanabe, A. Tumac, W. I. McDonald, D. A. Butterfield, P. P. Costa, F. deRino, F. Bamonti, J. M. Cesar, C. H. Lahoz, I. Mosely, M. Starck, M. H. Lemaitre, K. M. Stephan, S. Tex, R. Bokonjic, I. Mollee, L. Pastena, M. Gutierrez, F. Boiler, M. C. Martinez-Para, M. Velicogna, O. Obuz, A. Grinspan, M. Guarino, L. M. Cartier, E. Ruiz, D. Gambi, S. Messina, M. Villa, Michael G. Hanna, J. Valk, Leone Pascual, M. Clanet, Z. Argov, B. Ryniewicz, E. Magni, B. Berlanga, K. S. Wong, C. Gellera, C. Prevost, F. Gonzalez-Huix, R. Petraroli, J. E. G. Benedikz, I. Kojder, C. Bommelaer, L. Perusse, M. R. Bangioanni, Guy M. McKhann, A. Molina, C. Fresquet, E. Sindern, Florence Pasquier, M. J. Rosas, M. Altieri, O. Simoncini, M. Koutroumanidis, C. A. F. Tulleken, M. Dary-Auriol, S. Oueslati, H. Kruyer, I. Nishisho, C. R. Horning, A. Vital, G. V. Czettritz, J. Ph. Neau, B. Mihout, A. Ameri, M. Francis, S. Quasthoff, D. Taussig, S. Blunt, P. Valentin, C. Y. Gao, O. Heinzlef, H. d'Allens, C. Coudero, M. Erfas, G. Borghero, P. J. Modrego Pardo, M. C. Patrosso, N. L. Gershfeld, P. A. J. M. Boon, O. Sabouraud, M. Lara, J. Svennevig, G. L. Lenzi, A. Barrio, H. Villaroya, JosÇ M. Manubens, O. Boespflug-Tanguy, M. Carreras, D. A. Costiga, J. P. Breux, S. Lynn, C. Oliveras Ley, A. G. Herbaut, J. Nos, C. Tornali, Y. A. Hekster, J. L. Chopard, J. M. Manubens, P. Chemouilli, A. Jovicic, F. Dworzak, S. Smirne, S. E. Soudain, B. Gallano, D. Lubach, G. Masullo, G. Izquierdo, A. Pascual Leone Pascual, A. Sessa, V. Freitas, O. Crambes, L. Ouss, G. W. Van Dijk, P. Marchettini, P. Confalonieri, M. Donaghy, A. Munnich, M. Corbo, and M. E. L. van der Burg

Subjects
Neurology, business.industry, Media studies, Library science, Medicine, Neurology (clinical), business
Published
1994
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17. H2sorption performance of NaBH4–MgH2composites prepared by mechanical activation

Author

S. Garroni, S. Medici, A Girella, S. Enzo, M. D. Barò, S. Suriñach, A. Marini, C. Milanese, and G. Mulas

Subjects
Hydrogen storage, Materials science, Chemical engineering, Hydride, Desorption, Inorganic chemistry, Dehydrogenation, Sorption, Crystallite, Stoichiometry, Dissociation (chemistry)
Abstract

The current research on solid state hydrogen storage materials for on-board applications is focused on reactive hydrides composites (RHC), i.e. systems based on the improvement of the dehydrogenation thermodynamic of a complex hydride when one (generally the light hydride MgH2) or more hydrides take part to the reaction. The extent of the destabilization, as well as the sorption characteristics of the composites, strongly depends on the structural and nanostructural properties of the constituent hydrides, which are in turn affected by the preparation route. The aim of this work is to evaluate the influence of different mechanical activation conditions on the storage properties of NaBH4 – MgH2 composites, up to now scarcely explored in literature. The first results regard composites with 2:1 and 1:2 stoichiometry milled under different atmosphere (Ar or H2). X-ray powders diffraction analysis shows that milling does not lead to the formation of any new phase, but it reduces the average crystallite size of the powders down to nanometric scale. All the mixtures release an H2 amount close to the theoretical value expected for the full dissociation of both the hydrides and much higher than the target fixed by the US Department of Energy for on-board application. The thermal programmed desorption profiles of the mixtures clearly show two steps, with MgH2 dissociating first and with higher rate and NaBH4 gradually dehydrogenating at temperatures close to 400°C. Concerning the 2:1 stoichiometry, when the samples are processed under Ar the two dehydrogenation processes are characterized by a lower starting temperature but also by a lower average rate with respect to the sample milled in H2. The 1:2 sample milled under Ar shows the best kinetic performance. Unfortunately, also for this mixture more than 10 h are required to obtain full desorption at a temperature as high as 450°C.

Published
2009
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26. Development of an enzyme-linked immunosorbent assay with a monoclonal antibody prepared against alpha 1-antitrypsin for diagnostic screening of inflammatory disorders

Author

C. Milanese, A Guglielmotti, E Melanitou, J Grima, Bruno Silvestrini, C Y Cheng, and Luciano Saso

Subjects
medicine.drug_class, Immunoblotting, Clinical Biochemistry, Alpha (ethology), Hamster, Enzyme-Linked Immunosorbent Assay, Cross Reactions, Monoclonal antibody, Epitope, Arthritis, Rheumatoid, Guinea pig, Epitopes, Mixed connective tissue disease, medicine, Animals, Humans, Lupus Erythematosus, Systemic, Connective Tissue Diseases, Radial immunodiffusion, Chemistry, Biochemistry (medical), Antibodies, Monoclonal, medicine.disease, Molecular biology, Rats, alpha 1-Antitrypsin, Rheumatoid arthritis, Immunology, Electrophoresis, Polyacrylamide Gel, Papio
Abstract

A monoclonal antibody, designated A2a18b8, of IgG1 class prepared against human alpha 1-antitrypsin, cross-reacts with alpha 1-antitrypsin in the serum of rat and baboon, but not with alpha 1-antitrypsin in serum of rabbit, pig, hamster, guinea pig, dog, or turtle. We used A2a18b8 in an enzyme-linked immunosorbent assay (ELISA) developed for human alpha 1-antitrypsin. Preliminary ELISA screening of 247 serum samples from patients with various inflammatory disorders indicated that the concentration of a specific epitope(s) on alpha 1-antitrypsin recognized by this monoclonal antibody was increased significantly in patients with active systemic lupus erythematosus, mixed connective tissue disease, and rheumatoid arthritis, but not in patients with sclerodermic disorders or Sjögren's syndrome. Evidently, A2a18b8 has diagnostic value in that it selectively recognizes a specific epitope(s) on alpha 1-antitrypsin that is (are) apparently exposed during selective inflammatory disorders.

Published
1990
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27. Prevalence of primary headaches in people with multiple sclerosis

Author

D D'Amico, L La Mantia, A Rigamonti, S Usai, N Mascoli, C Milanese, G Bussone, and C. Besta

Subjects
Adult, Male, Pediatrics, medicine.medical_specialty, Multiple Sclerosis, Headache Disorders, 03 medical and health sciences, 0302 clinical medicine, Primary headache, medicine, Prevalence, Humans, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, Aged, Chi-Square Distribution, business.industry, Cluster headache, Multiple sclerosis, General Medicine, Middle Aged, medicine.disease, Exact test, Migraine, Physical therapy, Female, Neurology (clinical), Headaches, medicine.symptom, business, Chi-squared distribution, 030217 neurology & neurosurgery
Abstract

The aim was to investigate the lifetime prevalence of headache and primary headache (diagnoses according to International Headache Society criteria) in multiple sclerosis (MS). The relationships between headache and clinical features of MS and MS therapy were also investigated. We studied 137 patients with clinically definite MS; 88 reported headache, 21 of whom developed headache after the initiation of interferon. The prevalence of all headaches in the remaining 116 patients was 57.7%. Migraine was found in 25.0%, tension-type headache in 31.9%, and cluster headache in one patient. A significant correlation ( P = 0.007, Fisher's exact test) between migraine and relapsing-remitting MS was found. Primary headaches are common in MS patients. Further studies are needed to clarify the mechanisms underlying this association, particularly the association between migraine and relapsing-remitting MS, and the role of interferon in the development of new headache.

Published
2004

28. Acetaminophen protects hippocampal neurons and PC12 cultures from amyloid beta-peptides induced oxidative stress and reduces NF-kappaB activation

Author

M. Bisaglia, Gennaro Schettini, Patrizia Piccioli, Sabrina Stanzione, C. Milanese, Claudio Russo, C. Porcile, F. Mancini, and Valentina Venezia

Subjects
medicine.medical_specialty, Amyloid, Inflammation, Apoptosis, Electrophoretic Mobility Shift Assay, Pharmacology, Hippocampal formation, Biology, medicine.disease_cause, Hippocampus, PC12 Cells, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Internal medicine, medicine, Animals, Acetaminophen, Neurons, Amyloid beta-Peptides, NF-kappa B, NF-κB, Cell Biology, Peptide Fragments, Rats, Oxidative Stress, Endocrinology, medicine.anatomical_structure, chemistry, Cell culture, Neuron, medicine.symptom, Oxidative stress, medicine.drug
Abstract

The present findings show that an atypical non-steroidal anti-inflammatory drug, such as acetaminophen, retains the ability to recover amyloid beta-peptides driven neuronal apoptosis through the impairment of oxidative stress. Moreover, this compound reduces the increased NF-kappaB binding activity, which occurs in these degenerative conditions. Therapeutic interventions aimed at reducing the inflammatory response in Alzheimer's disease (AD) recently suggested the application of non-steroidal anti-inflammatory drugs. Although the anti-inflammatory properties of acetaminophen are controversial, it emerged that in an amyloid-driven astrocytoma cell degeneration model acetaminophen proved to be effective. On these bases, we analyzed the role of acetaminophen against the toxicity exerted by different Abeta-peptides on rat primary hippocampal neurons and on a rat pheochromocytoma cell line. We found a consistent protection from amyloid beta-fragments 1-40 and 1-42-induced impairment of mitochondrial redox activity on both cell cultures, associated with a marked reduction of apoptotic nuclear fragmentation. An antioxidant component of the protective activity emerged from the analysis of the reduction of phospholipid peroxidation, and also from a significant reduction of cytoplasmic accumulation of peroxides in the pheochromocytoma cell line. Moreover, activation of NF-kappaB by amyloid-derived peptides was greatly impaired by acetaminophen pre-treatment in hippocampal cells. This evidence points out antioxidant and anti-transcriptional properties of acetaminophen besides the known capability to interfere with inflammation within the central nervous system, and suggests that it can be exploited as a possible therapeutic approach against AD.

Published
2002

29. Transmigration of PBMNCs from beta-IFN-1b-treated MS patients: a one-year longitudinal study

Author

M, Gelati, E, Corsini, A, Dufour, M, Zaffaroni, C, Milanese, L, La Mantia, G, Massa, and A, Salmaggi

Subjects
Adult, Male, Multiple Sclerosis, Cell Movement, Leukocytes, Mononuclear, Humans, Female, Interferon-beta, Longitudinal Studies, Interferon beta-1a, Interferon beta-1b
Abstract

To evaluate the effects of in vivo beta-IFN-1b treatment on transmigration of mononuclear cells, we monitored for one year in vitro mononuclear cells trafficking through HUVECs monolayers stratified over a collagen gel during beta-IFN-1b treatment of 7 RR MS patients. The number of transmigrated cells was analysed before treatment (T0) and after 3 (T3), 6 (T6) and 12 months (T12); at the same time, levels of serum MMP-9 were quantified. The number of transmigrated cells decreased during treatment compared to pre-treatment values: the lowest number of transmigrated cells was detected at T3, and, although transmigration was still lower at T12, there was a trend to a return to pre-treatment levels over time. The amount of MMP-9 also decreased during therapy, although we could not find an absolute correlation between transmigration and levels of MMP-9, nor between either parameter and the clinical course of patients.

Published
2001

30. The SMile Card: a computerised data card for multiple sclerosis patients. SMile Card Scientific Board

Author

G L, Mancardi, M M, Uccelli, M, Sonnati, G, Comi, C, Milanese, A, De Vincentiis, and M A, Battaglia

Subjects
Europe, Multiple Sclerosis, Medical Records Systems, Computerized, Humans
Abstract

The SMile Card was developed as a means for computerising clinical information for the purpose of transferability, accessibility, standardisation and compilation of a national database of demographic and clinical information about multiple sclerosis (MS) patients. In many European countries, centres for MS are organised independently from one another making collaboration, consultation and patient referral complicated. Only the more highly advanced clinical centres, generally located in large urban areas, have had the possibility to utilise technical possibilities for improving the organisation of patient clinical and research information, although independently from other centres. The information system, developed utilising the Visual Basic language for Microsoft Windows 95, stores information via a 'smart card' in a database which is initiated and updated utilising a microprocessor, located at each neurological clinic. The SMile Card, currently being tested in Italy, permits patients to carry with them all relevant medical information without limitations. Neurologists are able to access and update, via the microprocessor, the patient's entire medical history and MS-related information, including the complete neurological examination and laboratory test results. The SMile Card provides MS patients and neurologists with a complete computerised archive of clinical information which is accessible throughout the country. In addition, data from the SMile Card system can be exported to other database programs.

Published
2000

31. Interferon beta treatment in relapsing-remitting multiple sclerosis: a post-marketing study in Lombardia, Italy. Multiple Sclerosis Centers of Lombardia, Italy

Author

C, Milanese, L, La Mantia, and R, Palumbo

Subjects
Adult, Male, Multiple Sclerosis, Relapsing-Remitting, Patient Dropouts, Treatment Outcome, Adjuvants, Immunologic, Italy, Recurrence, Product Surveillance, Postmarketing, Humans, Female, Interferon-beta
Abstract

The aim of the study was to evaluate the efficacy of interferon beta-1a (IFN-beta-1a) and beta-1b (IFN-beta-1b) in clinical practice for the treatment of relapsing-remitting multiple sclerosis (RR MS). Patients were selected and prospectively monitored according to a predefined protocol. An appropriate form was prepared to collect clinical data of multiple sclerosis patients attending the MS Centers of Lombardia, Italy. On 30 June 1998, 317 patients were treated with IFN-beta-1b and 156 with IFN-beta-1a. Basal expanded disability status scale (EDSS) and relapse frequency were similar in both groups of patients. The annual relapse rate consistently decreased from 1.76 to 0.63 at 1 year and to 0.51 at 2 years for the IFN-beta-1b group and from 1.6 to 1.0 at 1 year for the IFN-beta-1a group. Disability remained stable in most patients. Dropouts (20.5%) were affected by more active disease compared to patients who continued to be treated. This study confirms the efficacy of both treatments, showing a more marked effect than expected from the clinical trials' results, probably due to differences in selection criteria and exclusion of dropouts.

Published
2000

32. P.2.d.032 Glycogen synthase kinase 3 (GSK-3β) an emerging target for neurological disease: in silico study to investigate the binding mode of trazodone

Author

L. Olivieri, C. Milanese, G. Mangano, Rosella Ombrato, M. Magnani, N. Cazzolla, M.A. Alisi, G. Corso, C. Manelfi, and L. Polenzani

Subjects
Pharmacology, In silico, Trazodone, Disease, Biology, Psychiatry and Mental health, Neurology, Biochemistry, GSK-3, medicine, biology.protein, Pharmacology (medical), Neurology (clinical), GSK3A, Glycogen synthase, GSK3B, Biological Psychiatry, medicine.drug
Published
2009
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34. A small synthetic molecule capable of preferentially inhibiting the production of the CC chemokine monocyte chemotactic protein-1

Author

M, Sironi, A, Guglielmotti, N, Polentarutti, F, Fioretti, C, Milanese, M, Romano, C, Vigini, I, Coletta, S, Sozzani, S, Bernasconi, A, Vecchi, M, Pinza, and A, Mantovani

Subjects
Mice, Indazoles, Animals, Cytokines, Humans, Female, Chemokines, Propionates, Chemokine CCL2, Monocytes, Cell Line
Abstract

Blocking chemokine production or action is a major target for pharmacological intervention in different human diseases. Bindarit (2-methyl-2-[[1-(phenylmethyl)-1H-indazol-3yl]methoxy]propan oic acid) dose-dependently inhibited MCP-1 and TNF-alpha production induced in vitro in monocytes by LPS and Candida albicans. It did not affect the production of the cytokines IL-1, IL-6, or the chemokines IL-8, MIP-1alpha and RANTES. In the air pouch model in mice, oral treatment reduced monocyte recruitment and local MCP-1 production, induced by carrageenan or IL-1 injection. In NZB/W mice, a model of lupus nephritis, oral treatment prolonged survival and delayed the onset of proteinuria. The results presented here show that bindarit is a preferential inhibitor of the production of MCP-1 in vitro and in vivo and suggest that its beneficial effects in models of joint and kidney inflammation are related to its anti-MCP-1 action. It is therefore possible to selectively and differentially regulate chemokines by targeting their production with small synthetic molecules.

Published
1999

35. Inhibition of tumor necrosis factor-alpha (TNF-alpha)/TNF-alpha receptor binding by structural analogues of suramin

Author

F, Mancini, C M, Toro, M, Mabilia, M, Giannangeli, M, Pinza, and C, Milanese

Subjects
Models, Molecular, Antigens, CD, Protein Conformation, Receptors, Tumor Necrosis Factor, Type I, Tumor Necrosis Factor-alpha, Humans, Computer Simulation, Suramin, Binding, Competitive, Trypanocidal Agents, Receptors, Tumor Necrosis Factor
Abstract

Suramin, a symmetrical polysulfonated urea derivative, promotes the dissociation of trimeric human tumor necrosis factor-alpha (TNF-alpha) into biologically inactive subunits and prevents the interaction of TNF-alpha with its cellular receptors. The aim of this work was to identify compounds structurally related to suramin which inhibit the binding of TNF-alpha to its receptor. Molecular modeling studies were performed on suramin and TNF-alpha molecules and likely interaction sites were identified in the docked complex. On this basis, Evans blue, trypan blue, sulfonazo III, beryllon II, and 1,3,6-naphthalenetrisulfonic acid trisodium salt were identified as polysulfonated compounds endowed, to various extents, with the structural characteristics responsible for interaction with TNF-alpha. N,N-bis(3,5-di-tert-butylphenyl)-3,4,9,10-perylenedicarboximide was used as an unrelated structure. The capacity of these molecules to inhibit the binding of TNF-alpha with its receptor p55 was tested in vitro by means of a specific immunoenzymatic assay using suramin as reference compound. Evans blue and trypan blue inhibited TNF-alpha/p55 binding with an IC50 of 0.75 and 1.00 mM, respectively (suramin IC50: 0.65 mM); no effect was observed with the other molecules. Molecular modeling analyses on Evans blue and trypan blue docked into the TNF-alpha molecule support these experimental results by demonstrating that these compounds share with suramin a similar binding mode to TNF-alpha. The results of this work provide a new insight into and useful hints for the design of new chemical entities endowed with a potent and selective activity on TNF-alpha.

Published
1999

36. Bindarit prolongs survival and reduces renal damage in NZB/W lupus mice

Author

A, Guglielmotti, L, Aquilini, E, D'Onofrio, M T, Rosignoli, C, Milanese, and M, Pinza

Subjects
Mice, Proteinuria, Indazoles, Mice, Inbred NZB, Antibodies, Antinuclear, Animals, Lupus Erythematosus, Systemic, Female, DNA, Propionates, Kidney, Survival Analysis
Abstract

The present study was designed to investigate the effects of bindarit on animal survival and renal damage in murine lupus autoimmune disease.Female NZB/W mice were used. Bindarit was administered, as a 0.5% medicated diet, starting either before the onset of the pathology or early in the course of the disease, in order to assess the effects of age upon the response. Furthermore, the effects of combined administration of bindarit with low dose i.p. cyclophosphamide bolus were also studied. Proteinuria and anti-dsDNA antibody levels were determined during the course of the study. Renal damage was evaluated by light microscopy.Bindarit markedly prolonged the NZB/W mouse life span (p0.001 vs. controls), showing a significant difference even against high dose cyclophosphamide (90 mg/kg ip bolus) chosen as the reference (p0.01). Bindarit significantly reduced the degree of renal damage, delayed proteinuria and did not prevent autoantibody development, thus confirming the lack of immunosuppressive activity.The present results and other experimental data demonstrating the capacity of the drug to interfere with the inflammatory and immune response cross-talking, indicate that bindarit exerts its action in murine lupus through a novel and original mechanism. These findings, coupled with the evidence that the drug possesses a very safe toxicological profile, suggest that further investigations to assess the potential value of bindarit in the treatment of SLE are warranted.

Published
1998

37. Analysis of HLA-class II DQA1, DQB1, DRB1 and DPB1 in Italian multiple sclerosis patients

Author

Ulf Gyllensten, Marie Allen, M. Eoli, Angelo Nespolo, Magnhild Sandberg-Wollheim, A. Salmaggi, C. Milanese, and E. Ciusani

Subjects
musculoskeletal diseases, Hla class ii, HLA-DP Antigens, Multiple Sclerosis, endocrine system diseases, Immunology, Genes, MHC Class II, Biology, HLA-DQ alpha-Chains, Central nervous system disease, Gene Frequency, Immunopathology, HLA-DQ Antigens, Genetics, medicine, HLA-DQ beta-Chains, Humans, Genetic Predisposition to Disease, Typing, Allele, skin and connective tissue diseases, Alleles, HLA-DP beta-Chains, Autoimmune disease, HLA-D Antigens, Multiple sclerosis, nutritional and metabolic diseases, HLA-DR Antigens, medicine.disease, Glutamine, Italy, Disease Susceptibility, HLA-DRB1 Chains
Abstract

We studied the allelic constitution at the HLA class II DQA1, DQB1, DRB1 and DPB1 in 94 Italian multiple sclerosis (MS) patients and 98 controls. No significant increase in the frequency of DR2 alleles was detected among MS patients, as previously observed both in European and some Italian studies. A slight increase was found for the DQA1*0301 and DQB1*0602 alleles in the MS patients. No significant association was found with the glutamine residue at position 34 of the DQ alpha chain, which was noted previously in MS patients from northern Europe.

Published
1995

38. Synthesis of digoxigenin-labeled cDNA as a test for mRNA integrity

Author

L, Soldo, G, Mangano, and C, Milanese

Subjects
Genetic Techniques, Evaluation Studies as Topic, Molecular Probe Techniques, RNA-Directed DNA Polymerase, DNA, RNA, Messenger, DNA Probes, Deoxyuracil Nucleotides, Digoxigenin
Abstract

The nucleotide analogue digoxigenin-11-dUTP is widely used as a nonradioactive marker in a broad range of techniques including dot blots, Southern and Northern blots, colony and plaque screenings and in situ hybridizations. In this report, we describe the incorporation of this molecule into a cDNA synthesized by reverse transcriptase as a novel application for digoxigenin. This reaction can be performed as a useful control to check the integrity of a bulk mRNA preparation in the construction of a cDNA library, since the ability of mRNA to direct the synthesis of long molecules of first-strand cDNA is a sign of its integrity.

Published
1992

39. Immunological monitoring in systemic lupus erythematosus

Author

A, Salmaggi, E, Venegoni, M, Eoli, E, Lamperti, A, Dufour, E, Ciusani, C, Milanese, A, Nespolo, and C, Novi

Subjects
Adult, Adolescent, Recurrence, T-Lymphocyte Subsets, B-Lymphocyte Subsets, Humans, Interleukin-2, Lupus Erythematosus, Systemic, Prednisone, Female, Receptors, Interleukin-2, Middle Aged, Aged
Published
1992

40. Unmet needs in multiple sclerosis: the role of community services

Author

C Milanese

Subjects
medicine.medical_specialty, business.industry, media_common.quotation_subject, Multiple sclerosis, Psychological intervention, Community service, medicine.disease, Medical care, Unmet needs, Psychiatry and Mental health, Disease evolution, Family medicine, Medicine, Surgery, Quality (business), Neurology (clinical), business, Psychiatry, media_common
Abstract

Despite significant diagnostic and therapeutic advances in the past decades, multiple sclerosis still results, for most of the patients, in different degrees of disabilities that tend to progress over time, requiring various medical and non-medical interventions. Due to the variability in disease evolution, frequent assessments of patients' health status are necessary to provide the best management of their needs. High quality medical care, which usually requires expensive diagnostic and therapeutic procedures and the patient's admissison to hospital, should be supplemented by reabilitation programmes and social interventions aimed at preventing disabilities and promoting the …

Published
2000
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41. Effects of Petiveria Alliacea L. on Cytokine Production and Natural Killer Cell Activity

Author

B. Giardina, L. Jovicevic, V. Rossi, M. G. Leone, C. Milanese, Stefano Marini, and L. Tentori

Subjects
Pharmacology, Traditional medicine, medicine.drug_class, Natural Killer Cell Activity, medicine.medical_treatment, Nk activity, Biological activity, Pharmacognosy, Biology, biology.organism_classification, Immunostimulant, Natural killer cell, Cytokine, medicine.anatomical_structure, Immunology, medicine, Petiveria alliacea
Published
1993
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42. Subject Index Vol. 43, 2000

Author

José Antonio Cortés-Laíño, J.S. Romine, A. Münchau, Helge Topka, Laurent Tatu, R. Brüning, Suck Y. Kang, Francisco Brañas-Fernández, C. Milanese, J.A. Koziol, R. D’Amico, L.S. Slivka, Robustiano Pego-Reigosa, Francisco Martínez-Vázquez, Rolf Salvesen, Katrin Bürk, H. Brückmann, Luís Sanjuanbenito, Fabrice Vuillier, L. La Mantia, Seiitsu Ono, Takashi Imai, Alain Czorny, Michael Abele, Mercedes García-Villanueva, Maria Michalopoulou, Natsue Shimizu, T. Brandt, Lucien Rumbach, Rachid El Mohamad, M. Strupp, María José Rivas-Bande, G.F. Hamann, Thomas Klockgether, S. Wagner, Fabrice Robichon, Gregory Youngnam Chang, Koichi Nagao, D.F. Sobel, Stephen N. Scelsa, Jong S. Kim, Thierry Moulin, Jörg B. Schulz, Elisabeth Kapaki, Johannes Dichgans, J.C. Sipe, George P. Paraskevas, Pascal Bouchard, Intazam Khan, Jean-François Démonet, Konstantinos Kilidireas, Michel Habib, H.-P. Adams, and T. Rosenkranz

Subjects
Gerontology, Index (economics), Neurology, Subject (documents), Neurology (clinical), Psychology
Published
2000
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44. Value of otoneurological tests in the staging of multiple sclerosis

Author

D, Alpini, C, Milanese, and C, Berardi

Subjects
Adult, Multiple Sclerosis, Eye Movements, Nystagmus, Physiologic, Spinal Cord, Predictive Value of Tests, Age Factors, Saccades, Humans, Reflex, Vestibulo-Ocular, Vestibular Function Tests, Pursuit, Smooth, Brain Stem
Abstract

We looked for correlations between otoneurological findings and neurological signs in multiple sclerosis (MS). 41 patients were tested for: spontaneous and caloric nystagmus, horizontal pursuit eye tracking, full-field optokinetic nystagmus and eye movements. The findings were compared with the course of the disease (progressive or remitting), age at onset of MS and disability, in order to test the predictive value of this type of test. The correlation between otoneurological abnormalities and lesion site is very high for brainstem lesions. Subclinical brainstem lesions were detected in 66% of patients with optic neuritis only and in 42% of those with spinal cord involvement only. Eye movement disorders are more frequent (p less than 0.1) in disease of long duration. The vestibular examination was altered in 100% of patients with clinically definite and probable MS, in 91% of those with possible and in 80% of those with suspected MS. No specific otoneurological pattern was identified. No significant correlation with age at onset or with disability was found.

Published
1987

45. Characterization of a New Hgprt(-) Human B Lymphoid Cell Line

Author

L. Moriondo, Giuseppe Saglio, Giuseppe Piccoli, C. Milanese, F. Caligaris Cappio, Angelo O. Carbonara, Fabio Malavasi, and B. Alhadeff

Subjects
Genetics, Cell culture, Hypoxanthine-guanine phosphoribosyltransferase, Line (text file), Biology, Molecular biology
Abstract

This paper summarizes the results of the establishment and characterization of a new HGPRT(-) human B lymphoid line, whose features seem to be suitable for use as tumour partner in the production of human-human hybridomas.

Published
1984
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46. Double-blind randomized trial of ACTH versus dexamethasone versus methylprednisolone in multiple sclerosis bouts. Clinical, cerebrospinal fluid and neurophysiological results

Author

C, Milanese, L, La Mantia, A, Salmaggi, A, Campi, M, Eoli, V, Scaioli, A, Nespolo, and F, Corridori

Subjects
Adult, Random Allocation, Multiple Sclerosis, Adolescent, Adrenocorticotropic Hormone, Dose-Response Relationship, Drug, Double-Blind Method, Evoked Potentials, Auditory, Evoked Potentials, Visual, Humans, Methylprednisolone, Dexamethasone
Abstract

30 patients with acute exacerbations of multiple sclerosis were treated by ACTH, dexamethasone or methylprednisolone in a double-blind randomized study. Clinical parameters were assessed; cerebrospinal fluid and neurophysiological parameters (visual- and brainstem-evoked potentials) were evaluated at the beginning and at the end of treatment. Dexamethasone was more effective than ACTH and 6-methylprednisolone in shortening bout duration. Neither CSF nor neurophysiological parameters were significantly affected by therapy.

Published
1989

47. Characterization of a murine monoclonal antibody specific for human early lymphohemopoietic cells

Author

Federico Caligaris-Cappio, Fabio Malavasi, Paolo Dellabona, C. Milanese, Patricia Richiardi, and Angelo O. Carbonara

Subjects
animal structures, Lineage (genetic), Lymphoma, Antibodies, Neoplasm, medicine.drug_class, Cellular differentiation, Immunology, Cell, Biology, Monoclonal antibody, Epitope, Mice, Antigen, Antibody Specificity, Antigens, Neoplasm, medicine, Animals, Humans, Immunology and Allergy, Lymphocytes, Antigens, Leukemia, Antibodies, Monoclonal, Cell Differentiation, General Medicine, T lymphocyte, Hematopoietic Stem Cells, Virology, Molecular biology, Histocompatibility, medicine.anatomical_structure, Female
Abstract

This paper summarizes the results of the characterization of A10, a murine monoclonal antibody which recognizes an epitope not restricted to cells of a definite lineage, but which seems to be specific for an early differentiation antigen present on precursors of circulating T and B cells. The structure recognized by the A10 monoclonal antibody, although strikingly structurally similar to the HLA-A,B,C complex, is immunologically different both from histocompatibility antigens and from β2microglobulin. Furthermore, the distribution of the A10 antigen is analyzed in different cell and tissue samples, both in health and disease conditions.

Published
1984

50. [Characterization of a human lymphoid line with HGPRTase deficiency]

Author

C, Milanese, F, Caligaris Cappio, B, Alhadeff, G, Piccoli, L, Moriondo, S, Roggero, G, Saglio, and F, Malavasi

Subjects
Hypoxanthine Phosphoribosyltransferase, Hybridomas, Bone Marrow, Autoradiography, Fluorescent Antibody Technique, Humans, Multiple Myeloma, Cell Line, Culture Media
Published
1983

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