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We report the detection of ammonia masers in the non-metastable (6, 3), (7, 5) and (6, 5) transitions, the latter is the first unambiguous maser detection of that transition ever made. Our observations include the first VLBI detection of ammonia maser emission, which allowed effective constrain of the (6, 5) maser brightness temperature. The masers were detected towards G358.931-0.030, a site of 6.7-GHz class~II methanol maser emission that was recently reported to be undergoing a period of flaring activity. These ammonia masers appear to be flaring contemporaneously with the class~II methanol masers during the accretion burst event of G358.931-0.030. This newly detected site of ammonia maser emission is only the twelfth such site discovered in the Milky Way. We also report the results of an investigation into the maser pumping conditions, for all three detected masing transitions, through radiative transfer calculations constrained by our observational data. These calculations support the hypothesis that the ammonia (6, 5) maser transition is excited through high colour temperature infrared emission, with the (6, 5) and (7, 5) transition line-ratio implying dust temperatures >400K. Additionally, we detect significant linearly polarised emission from the ammonia (6, 3) maser line. Alongside our observational and radiative transfer calculation results, we also report newly derived rest frequencies for the ammonia (6, 3) and (6, 5) transitions., Accepted into MNRAS 2023 April 24. 13 pages, 5 figures, 3 tables

High-mass protostars (M$_{\star} >$ 8 M$_{\odot}$) are thought to gain the majority of their mass via short, intense bursts of growth. This episodic accretion is thought to be facilitated by gravitationally unstable and subsequently inhomogeneous accretion disks. Limitations of observational capabilities, paired with a lack of observed accretion burst events has withheld affirmative confirmation of the association between disk accretion, instability and the accretion burst phenomenon in high-mass protostars. Following its 2019 accretion burst, a heat-wave driven by a burst of radiation propagated outward from the high-mass protostar G358.93-0.03-MM1. Six VLBI (very long baseline interferometry) observations of the raditively pumped 6.7 GHz methanol maser were conducted during this period, tracing ever increasing disk radii as the heat-wave propagated outward. Concatenating the VLBI maps provided a sparsely sampled, milliarcsecond view of the spatio-kinematics of the accretion disk covering a physical range of $\sim$ 50 - 900 AU. We term this observational approach `heat-wave mapping'. We report the discovery of a Keplerian accretion disk with a spatially resolved four-arm spiral pattern around G358.93-0.03-MM1. This result positively implicates disk accretion and spiral arm instabilities into the episodic accretion high-mass star formation paradigm., Published in Nature Astronomy in 2023

A new tool to identify possible Zeeman pairs is presented here: the right circularly polarized (RCP) and left circularly polarized (LCP) components of a pair with velocity drift at the same rate. Long-term monitoring of hydroxyl transitions towards NGC 6334I-MM3 has resulted in the identification of three possible Zeeman pairs, one each at the 1.667, 6.030, and 6.035 GHz transitions, where the rate of drift of the RCP feature equals that of the LCP component. Historical observations suggest that their drift has been occurring over 40 yr. A fourth pair in the 1.720 GHz OH transition may indicate magnetic field variation over 50 yr.

We examine the long-term history of the optical spectrum of the extremely variable Active Galactic Nucleus (AGN) MKN 110. By combining various archival data with new data, we cover an unprecedented long period of $\sim$30 years (1987 - 2019). We find that the He II $\lambda 4686$ emission line changes by a factor of forty and varies more strongly than the optical continuum. Following Ferland et al. (2020), we take He II $\lambda 4686$ as a proxy for the FUV continuum and compare the flux of several other line species against it. This comparison reveals a clear pattern, whereby lines respond close to linearly at low FUV fluxes, and saturate at high FUV fluxes. The saturation level of the response appears to depend on the excitation energy of the line species. In addition to this global pattern, we note changes among observational epochs, indicating a structural evolution in the broad line region (BLR). The line profiles in our spectra show an offset between the narrow and broad components of the He II $\lambda 4686$ and H$\beta$ lines. This offset shows a significant negative correlation with the FUV flux and a positive correlation with the line velocity width. Our analysis reveals a complex BLR response to a changing continuum. The clear presence of a non-responsive component of the broad lines indicates the existence of multiple contributions to the line emission. We find there are several kinematic models of the BLR and inner regions of the AGN that match our data., Comment: 19 pages, 11 figures, 6 tables

Figure S1: HMC1.2 cell line has constitutively actived NFAT2, NFAT2 and NFAT4 species; Figure S2: RT-PCR of transcripts modulated by 24 hour treatment with CSA; Figure S3: CNPIs do not modulate KIT signaling and KIT inhibitors do not affect NFAT localization; Figure S4: Combination therapy does not enhance the effect of KIT inhibitors on KIT or downstream signaling; Table S1: Summary of KIT-mutant mast cell characteristics; Table S2: Summary of antibodies used in immunoblotting experiments; Table S3: qRT-PCR analysis of NFAT expression in KIT-mutant mast cell lines.

Resistant KIT mutations have hindered the development of KIT kinase inhibitors for treatment of patients with systemic mastocytosis. The goal of this research was to characterize the synergistic effects of a novel combination therapy involving inhibition of KIT and calcineurin phosphatase, a nuclear factor of activated T cells (NFAT) regulator, using a panel of KIT-mutant mast cell lines. The effects of monotherapy or combination therapy on the cellular viability/survival of KIT-mutant mast cells were evaluated. In addition, NFAT-dependent transcriptional activity was monitored in a representative cell line to evaluate the mechanisms responsible for the efficacy of combination therapy. Finally, shRNA was used to stably knockdown calcineurin expression to confirm the role of calcineurin in the observed synergy. The combination of a KIT inhibitor and a calcineurin phosphatase inhibitor (CNPI) synergized to reduce cell viability and induce apoptosis in six distinct KIT-mutant mast cell lines. Both KIT inhibitors and CNPIs were found to decrease NFAT-dependent transcriptional activity. NFAT-specific inhibitors induced similar synergistic apoptosis induction as CNPIs when combined with a KIT inhibitor. Notably, NFAT was constitutively active in each KIT-mutant cell line tested. Knockdown of calcineurin subunit PPP3R1 sensitized cells to KIT inhibition and increased NFAT phosphorylation and cytoplasmic localization. Constitutive activation of NFAT appears to represent a novel and targetable characteristic of KIT-mutant mast cell disease. Our studies suggest that combining KIT inhibition with NFAT inhibition might represent a new treatment strategy for mast cell disease. Mol Cancer Ther; 13(12); 2840–51. ©2014 AACR.

Figure and table legends for supplemental figures 1-4 and supplemental tables 1-3.

High-mass stars are thought to accumulate much of their mass via short, infrequent bursts of disk-aided accretion. Such accretion events are rare and difficult to observe directly but are known to drive enhanced maser emission. In this Letter we report high-resolution, multi-epoch methanol maser observations toward G358.93-0.03 which reveal an interesting phenomenon; the sub-luminal propagation of a thermal radiation "heat-wave" emanating from an accreting high-mass proto-star. The extreme transformation of the maser emission implies a sudden intensification of thermal infrared radiation from within the inner (40 mas, 270 au) region. Subsequently, methanol masers trace the radial passage of thermal radiation through the environment at $\geq$ 4-8\% the speed of light. Such a high translocation rate contrasts with the $\leq$ 10 km s$^{-1}$ physical gas motions of methanol masers typically observed using very long baseline interferometry (VLBI). The observed scenario can readily be attributed to an accretion event in the high-mass proto-star G358.93-0.03-MM1. While being the third case in its class, G358.93-0.03-MM1 exhibits unique attributes hinting at a possible `zoo' of accretion burst types. These results promote the advantages of maser observations in understanding high-mass star formation, both through single-dish maser monitoring campaigns and via their international cooperation as VLBI arrays., Comment: Published in Nature Astronomy in 2020

Introduction:Our urology residency program transitioned to a night float system, where dedicated residents cover nights and are off duty during the day. Junior residents previously covered ...

The first confirmed periodically varying 6.031 and 6.035 GHz hydroxyl masers are reported here. They vary contemporaneously with the 6.7 GHz methanol masers in G323.459–0.079. The 1.665 GHz hydroxyl and 12.2 GHz methanol masers associated with G323.459–0.079 are also periodic. Evidence for periodicity is seen in all features in all transitions save a single 1.665 GHz hydroxyl maser feature. Historical excited-state hydroxyl maser observations set a stricter upper limit on the epoch in which a significant accretion event occurred. The associated burst in 6.7 GHz methanol maser activity has subsided significantly while the hydroxyl transitions are brightening possibly the result of changing physical conditions in the masing cloudlets. Time lags in methanol are confirmed and may be the result of the periodic flaring propagating outward from the central region of maser activity. A possible magnetic field reversal occurred during the accretion event.

Context. The massive young stellar object (MYSO) G358.93-0.03-MM1 showed an extraordinary near-infrared- to (sub-)millimetredark and far-infrared-loud accretion burst, which is closely associated with flares of several class II methanol maser transitions, and, later, a 22 GHz water maser flare. Aims. Water maser flares provide an invaluable insight into ejection events associated with accretion bursts. Although the short timescale of the 22 GHz water maser flare made it impossible to carry out a very long baseline interferometry observation, we could track it with the Karl G. Jansky Very Large Array (VLA). Methods. The evolution of the spatial structure of the 22 GHz water masers and their association with the continuum sources in the region is studied with the VLA during two epochs, pre- and post-H2O maser flare. Results. A drastic change in the distribution of the water masers is revealed: in contrast to the four maser groups detected during epoch I, only two newly formed clusters are detected during epoch II. The 22 GHz water masers associated with the bursting source MM1 changed in morphology and emission velocity extent. Conclusions. Clear evidence of the influence of the accretion burst on the ejection from G358.93-0.03-MM1 is presented. The accretion event has also potentially affected a region with a radius of ∼200 (∼13 500AU at 6.75 kpc), suppressing water masers associated with other point sources in this region. © O. S. Bayandina et al. 2022. Japan Society for the Promotion of Science, KAKEN: JP21H00032, JP21H01120, JP24340034; Ministry of Education and Science of the Russian Federation, Minobrnauka: 075-15-2020-780; National Astronomical Observatory of Japan, NAOJ Acknowledgements. The Ibaraki 6.7-GHz Methanol Maser Monitor (iMet) program is partially supported by the Inter-university collaborative project “Japanese VLBI Network (JVN)” of NAOJ and JSPS KAKENHI Grant Numbers JP24340034, JP21H01120, and JP21H00032 (YY). The National Radio Astronomy Observatory is a facility of the National Science Foundation operated under cooperative agreement by Associated Universities, Inc. This paper makes use of the following ALMA data: ADS/JAO.ALMA#2019.1.00768.S. ALMA is a partnership of ESO (representing its member states), NSF (USA) and NINS (Japan), together with NRC (Canada), MOST and ASIAA (Taiwan), and KASI (Republic of Korea), in cooperation with the Republic of Chile. The Joint ALMA Observatory is operated by ESO, AUI/NRAO and NAOJ. In addition, publications from NA authors must include the standard NRAO acknowledgement: The National Radio Astronomy Observatory is a facility of the National Science Foundation operated under cooperative agreement by Associated Universities, Inc. A.M.S. acknowledges support by the Ministry of Science and Higher Education of the Russian Federation under the grant 075-15-2020-780. A.C.G. acknowledges support by PRIN-INAF-MAIN-STREAM 2017 “Protoplanetary disks seen through the eyes of new-generation instruments” and by PRIN-INAF 2019 “Spectroscopically tracing the disk dispersal evolution (STRADE)”.

The source G9.62+0.20E surprises again! Several of the associated 6.7- and 12.2-GHz methanol masers are experiencing contemporaneous and systematic velocity drifts. Both 6.7- and 12.2-GHz methanol features blueward of v = +1.2 km s−1 are blue shifting while those redward are red shifting. A best-fitting rotating Keplerian disc with a central mass of ∼12 M⊙, radii Rinner = 5 au and Router = 5000 au, and at an inclination angle of 22○ either precessing and/or experiencing infall explains these systematic velocity drifts. Also three more distinct 6.7-GHz methanol maser features are found to vary periodically; two very weak and one obviously periodic only after 2003. Evidence of periodicity is seen as early as 1992. Time lags are confirmed but the cause is unclear. It is possible this source will surprise again.

Objective:The Cognition Battery of the National Institute of Health (NIH) Toolbox for Assessment of Neurological and Behavioural Function is a computerised neuropsychological battery recommended for clinical practice, neurological research and clinical trials. We investigated the utility of the NIH Toolbox Cognition Battery (NIHTB-CB) for people with concussion.Methods:In this small qualitative study, semi-structured interviews were conducted with five adults with concussion who were participating in a larger study using the NIHTB-CB. Three clinician participants and two cultural advisors familiar with the tool were also interviewed. Interview transcripts were analysed using a general thematic approach and qualitative description.Results:Participants described both positive and negative experiences with the NIHTB-CB and using qualitative description, their experiences were organised into three broad themes: (1) using technology for cognitive testing made sense, (2) there were some cultural relevance questions and (3) cognitive testing after concussion could have challenges. They were positive about the computerised format and range of domains assessed for the concussion context but identified the contextual relevance of some content as having potential to impact on performances.Conclusion:This was a small study examining the experiences of a select group of participants, but nevertheless does suggest a need for future research validating the NIHTB-CB for use in different cultural and clinical contexts.

There are multiple indications for luminal imaging of the colon. From assessment of known disease, to diagnosing new pathology; intra-luminal visualisation is the mainstay of gastrointestinal diagnosis. Colonoscopy and radiological imaging are currently the most frequently deployed diagnostic methods. However, both have an associated risk profile, have significant resource pressures and are not universally tolerated. Colon capsule endoscopy (CCE) offers an adjunct to these diagnostic options. In this narrative review the utility of CCE is described. Its current uses, potential benefits and future developments are also discussed.