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Pure-tone thresholds have long served as a gold standard for evaluating hearing sensitivity and documenting hearing changes related to medical treatments, toxic or otherwise hazardous exposures, ear disease, genetic disorders involving the ear, and deficits that develop during aging. Although the use of pure-tone audiometry is basic and standard, interpretation of thresholds obtained at multiple frequencies in both ears over multiple visits can be complex. Significant additional complexity is introduced when audiometric tests are performed within ototoxicity monitoring programs to determine if hearing loss occurs as an adverse reaction to an investigational medication and during the design and conduct of clinical trials for new otoprotective agents for noise and drug-induced hearing loss. Clinical trials using gene therapy or stem cell therapy approaches are emerging as well with audiometric outcome selection further complicated by safety issues associated with biological therapies. This review addresses factors that must be considered, including test-retest variability, significant threshold change definitions, use of ototoxicity grading scales, interpretation of early warning signals, measurement of notching in noise-induced hearing loss, and application of age-based normative data to interpretation of pure-tone thresholds. Specific guidance for clinical trial protocols that will assure rigorous methodological approaches and interpretable audiometric data are provided.

To elucidate D-methionine's (D-met) dose and time rescue parameters from steady-state or impulse noise-induced permanent threshold shift (PTS) and determine D-met rescue's influence on serum and cochlear antioxidant levels.Five D-met doses at 0, 50, 100, or 200 mg/kg/dose administered starting at 1, 24, or 36 hours post steady-state or impulse noise exposure. Auditory brainstem responses at baseline and 21 days post-noise measured PTS. Serum (superoxide dismutase [SOD], catalase [CAT],, glutathione reductaseand glutathione peroxidase [GPx]) and cochlear (Glutathione [GSH] and glutathione disulphide [GSSG]) antioxidant levels measured physiological impact.D-met significantly reduced PTS for impulse noise (100 mg [2, 6, 14 and 20 kHz]; 200 mg [2, 14 and 20 kHz]) and steady-state noise (all dosing groups, time parameters and tested frequencies). PTS reduction did not significantly vary by rescue time. D-met significantly increased serum SOD (100 and 200 mg for 24 hour rescue) and GPx (50 mg/kg at 24 hour rescue) at 21 days post-noise. Cochlear GSH and GSSG levels were unaffected relative to control.D-met rescues from steady-state and impulse noise-induced PTS even when administered up to 36 hours post-noise and dose-dependently influences serum antioxidant levels even 21 days post-noise. D-met's broad and effective dose/time window renders it a promising antioxidant rescue agent.

New half-lives for exotic isotopes approaching the neutron drip-line in the vicinity of N∼28 for Z=12-15 were measured at the Facility for Rare Isotope Beams (FRIB) with the FRIB decay station initiator. The first experimental results are compared to the latest quasiparticle random phase approximation and shell-model calculations. Overall, the measured half-lives are consistent with the available theoretical descriptions and suggest a well-developed region of deformation below ^{48}Ca in the N=28 isotones. The erosion of the Z=14 subshell closure in Si is experimentally confirmed at N=28, and a reduction in the ^{38}Mg half-life is observed as compared with its isotopic neighbors, which does not seem to be predicted well based on the decay energy and deformation trends. This highlights the need for both additional data in this very exotic region, and for more advanced theoretical efforts.

Imperfections in analog-to-digital conversion (ADC) cannot be ignored when signal digitization requirements demand both wide dynamic range and high resolution, as is the case for the Majorana Demonstrator 76Ge neutrinoless double-beta decay search. Enabling the experiment’s high-resolution spectral analysis and efficient pulse shape discrimination required careful measurement and correction of ADC nonlinearities. A simple measurement protocol was developed that did not require sophisticated equipment or lengthy data-taking campaigns. A slope-dependent hysteresis was observed and characterized. A correction applied to digitized waveforms prior to signal processing reduced the differential and integral nonlinearities by an order of magnitude, eliminating these as dominant contributions to the systematic energy uncertainty at the double-beta decay $Q$ value.

Objective: This exploratory Phase 2 clinical trial is the first determining safety and efficacy of oral D-methionine (D-met) in reducing cisplatin-induced ototoxicity.Design: Randomised parallel do...

Objective Determine if D-methionine (D-met) rescue prevents temporary threshold shift (TTS) from steady-state or impulse noise and determine D-met's impact on serum and cochlear antioxidant levels. Design D-met at 50, 100 or 200 mg/kg/doses were administered 0, 6 and 18 hours-post noise. ABRs at baseline and 24 hours post-noise measured TTS. Serum (SOD, CAT, GR, GPx) and cochlear (GSH, GSSG) antioxidant levels measured physiological influence. Three control groups, with impulse or steady-state or without noise, were saline-injected. Study sample Ten Chinchillas/group. Results D-met rescue did not significantly reduce TTS or impact serum CAT, SOD, GPx or GR levels vs. noise-exposed control groups, but TTS was greater in all groups relative to no-noise controls. D-met significantly elevated CAT at 50 mg/kg vs. steady-state controls and SOD at 200 mg/kg vs. impulse noise controls. D-met significantly reduced cochlear GSH/GSSG ratios in the 100 mg/kg D-met group vs. impulse noise controls. Conclusions While D-met rescue has reduced permanent threshold shift in previous studies, it did not reduce TTS in this study. However, D-met rescue did alter selective serum and cochlear oxidative state changes 24 hours post-noise relative to controls. Results demonstrate TTS studies do not always predict PTS protection in otoprotectant experimental designs.

The signatures of inversion between normal and intruder configurations of particle-hole excitations across the $N=20$ shell gap in the neutron-rich isotope $^{32}\mathrm{Mg}$ have long been of keen interest. Electromagnetic transition rates in the ground-state band are key quantities that provide insights into collective properties associated with the contributions of the 2p2h and 4p4h intruder configurations. The combination of TRIPLEX, GRETINA, and the S800 spectrograph enables model-independent lifetime measurements to determine electromagnetic transition rates in rare isotopes. The reduced $E2$ transition rates in $^{32}\mathrm{Mg}$ between the ${2}_{1}^{+}$ and ${0}_{1}^{+}$ states and between the ${4}_{1}^{+}$ and ${2}_{1}^{+}$ states have been measured, the latter representing the first experimental $B(E2)$ value for this transition. The $B(E2)$ strengths indicate large collectivity and strong contributions from the 2p2h and 4p4h intruder configurations that may change with spin in the ground-state band of $^{32}\mathrm{Mg}$.

Self-conjugate nuclei in the A ≈ 70 – 80 region have attracted a great deal of attention due to phenomena such as shape coexistence and increasing collectivity along the N = Z line. We investigate the structure of nuclei in this region through lifetime measurements using the GRETINA array. The first implementation of the Differential Recoil Distance Doppler Shift technique with fast radioactive beams is demonstrated and verified through a measurement of the well-known B ( E 2 ; 2 1 + → 0 1 + ) transition strength in 74Kr. The method is then applied to determine the B ( E 2 ; 2 1 + → 0 1 + ) transition strength in 74Rb, the heaviest odd–odd N = Z nucleus for which this quantity has been determined. This result and extended systematics along N = Z suggest the dominance of the isoscalar part of the quadrupole transition strengths in self-conjugate nuclei, as well as the possible presence of shape coexistence in 74Rb.

Author(s): Salathe, M; Crawford, HL; Macchiavelli, AO; Kay, BP; Hoffman, CR; Ayangeakaa, AD; Campbell, CM; Clark, RM; Cromaz, M; Fallon, P; Jones, MD; Kuvin, SA; Sethi, J; Wiedeking, M; Winkelbauer, JR; Wuosmaa, AH | Abstract: The excitation energy of deformed intruder states (specifically the 2p2h bandhead) as a function of proton number Z along N=20 is of interest both in terms of better understanding the evolution of nuclear structure between spherical Ca40 and the Island of Inversion nuclei, and for benchmarking theoretical descriptions in this region. At the center of the N=20 Island of Inversion, the npnh (where n=2,4,6) neutron excitations across a diminished N=20 gap result in deformed and collective ground states, as observed in Mg32. In heavier isotones, npnh excitations do not dominate in the ground states but are present in the relatively low-lying level schemes. With the aim of identifying the expected 2p2h - s1/2+ state in P35, the only N=20 isotone for which the neutron 2p2h excitation bandhead has not yet been identified, the S36(d,He3)P35 reaction has been revisited in inverse kinematics with the HELical Orbit Spectrometer (HELIOS) at the Argonne Tandem Linac Accelerator System (ATLAS). While a candidate state has not been located, an upper limit for the transfer reaction cross section to populate such a configuration within a 2.5 to 3.6 MeV energy range provides a stringent constraint on the wave function compositions in both S36 and P35.

Spectroscopic factors to low-lying negative-parity states in $^{11}$Be extracted from the $^{12}$B($d$,$^3$He)$^{11}$Be proton-removal reaction are interpreted within the rotational model. Earlier predictions of the $p$-wave proton removal strengths in the strong coupling limit of the Nilsson model underestimated the spectroscopic factors to the $3/2^-_1$ and $5/2^-_1$ states and suggested that deviations in the $1^+$ ground state of the odd-odd $^{12}$B due to Coriolis coupling should be further explored. In this work we use the Particle Rotor Model to take into account these effects and obtain a good description of the level scheme in $^{11}$B, with a moderate $K$-mixing of the proton Nilsson levels [110]1/2 and [101]3/2. This mixing, present in the $1^+$ bandhead of $^{12}$B, is key to explaining the proton pickup data., 5 Pages, 2 Figures, to be submitted to Phys. Rev. C

In a recent experiment, carried out at the Radioactive Isotope Beam Factory/RIKEN, the $^{25}\mathrm{F}(p,2p)^{24}\mathrm{O}$ reaction was studied at 270 MeV/A in inverse kinematics. Derived spectroscopic factors suggest that the effective core of $^{25}\mathrm{F}$ significantly differs from a free $^{24}\mathrm{O}$ nucleus. We interpret these results within the particle-rotor model and show that the experimental level scheme of $^{25}\mathrm{F}$ can be understood in the rotation-aligned coupling scheme with its $5/{2}_{1}^{+}$ ground state as the bandhead of a decoupled band. The excitation energies of the observed $1/{2}_{1}^{+}$ and $9/{2}_{1}^{+}$ states correlate strongly with the rotational energy of the effective core, seen by the odd proton, and allow us to estimate its ${2}^{+}$ energy at $\ensuremath{\approx}3.2\phantom{\rule{0.28em}{0ex}}\mathrm{MeV}$ and a moderate quadrupole deformation ${\ensuremath{\epsilon}}_{2}\ensuremath{\approx}0.15$. The measured fragmentation of the $\ensuremath{\pi}{d}_{5/2}$ single-particle strength is discussed, and some further experiments suggested.

The low-spin structure of the semimagic ^{64}Ni nucleus has been considerably expanded: combining four experiments, several 0^{+} and 2^{+} excited states were identified below 4.5 MeV, and their properties established. The Monte Carlo shell model accounts for the results and unveils an unexpectedly complex landscape of coexisting shapes: a prolate 0^{+} excitation is located at a surprisingly high energy (3463 keV), with a collective 2^{+} state 286 keV above it, the first such observation in Ni isotopes. The evolution in excitation energy of the prolate minimum across the neutron N=40 subshell gap highlights the impact of the monopole interaction and its variation in strength with N.

In an experiment performed at Lawrence Berkeley National Laboratory's 88-inch cyclotron, the isotope ^{244}Md was produced in the ^{209}Bi(^{40}Ar,5n) reaction. Decay properties of ^{244}Md were measured at the focal plane of the Berkeley Gas-filled Separator, and the mass number assignment of A=244 was confirmed with the apparatus for the identification of nuclide A. The isotope ^{244}Md is reported to have one, possibly two, α-decaying states with α energies of 8.66(2) and 8.31(2) MeV and half-lives of 0.4_{-0.1}^{+0.4} and ∼6 s, respectively. Additionally, first evidence of the α decay of ^{236}Bk was observed and is reported.

In an experiment performed at Lawrence Berkeley National Laboratory's 88-inch cyclotron, the isotope ^{244}Md was produced in the ^{209}Bi(^{40}Ar,5n) reaction. Decay properties of ^{244}Md were measured at the focal plane of the Berkeley Gas-filled Separator, and the mass number assignment of A=244 was confirmed with the apparatus for the identification of nuclide A. The isotope ^{244}Md is reported to have one, possibly two, α-decaying states with α energies of 8.66(2) and 8.31(2) MeV and half-lives of 0.4_{-0.1}^{+0.4} and ∼6 s, respectively. Additionally, first evidence of the α decay of ^{236}Bk was observed and is reported.

The superfluid tunneling model is applied to the calculation of ground-state--to--ground-state \ensuremath{\alpha} decay in the even-even neutron-deficient Te-Ba nuclei. We show that there is a larger \ensuremath{\alpha}-particle formation probability in nuclei of this region above $^{100}\mathrm{Sn}$ when compared to analogous nuclei above $^{208}\mathrm{Pb}$. This is consistent with the expected systematic variation of the pair gap $\mathrm{\ensuremath{\Delta}}$ as a function of mass number. The recent experimental data on the \ensuremath{\alpha} decay of the $N=Z$ nuclei $^{104}\mathrm{Te}$ and $^{108}\mathrm{Xe}$ are shown to leave open the possibility of enhanced \ensuremath{\alpha}-particle formation involving nucleon correlations beyond the standard treatment of like-nucleon pairing, which is the mechanism suggested as underlying ``superallowed'' \ensuremath{\alpha} decay.

New experimental data obtained from γ-ray tagged one-neutron and one-proton knockout from 55Co is presented. A candidate for the sought-after T = 1, T z = 0, Jπ = 6+ state in 54Co is proposed based on a comparison to the new data on 54Fe, the corresponding observables predicted by large-scale-shell-model (LSSM) calculations in the full fp-model space employing charge-dependent contributions, and isospin-symmetry arguments. Furthermore, possible isospin-symmetry breaking in the A = 54, T = 1 triplet is studied by calculating the experimental c coefficients of the isobaric mass multiplet equation (IMME) up to the maximum possible spin J = 6 expected for the (1f7/2)-2 two-hole configuration relative to the doubly-magic nucleus 56Ni. The experimental quantities are compared to the theoretically predicted c coefficients from LSSM calculations using two-body matrix elements obtained from a realistic chiral effective field theory potential at next-to-next-to-next-to leading order (N3LO).

Ototoxicity diagnosis and management has historically been approached using a variety of methods. However, in recent years a consensus on useful and practical approaches has been developed through clinical guidelines of the American Speech Language Hearing Association, the American Academy of Audiology, and multiple clinical trials published in peer-reviewed literature. Some of the guidelines and approaches are used to detect and monitor ototoxicity, while others are used to grade adverse events. Some of the audiologic measures are primary, while others are adjunct measures and may be tailored to the specific needs of the patient or clinical trial. For some types of monitoring, such as drug-induced tinnitus or dizziness, validated paper survey instruments can be both sensitive and easy for fragile patients. This review addresses the characteristics of some of the most common clinical ototoxins and the most common methods for detecting and monitoring ototoxicity in clinical practice and clinical trials.

The structure of 71Zn was investigated by one-neutron transfer and heavy-ion induced complex (deep-inelastic) reactions using the GRETINA-CHICO2 and the Gammasphere setups, respectively. The observed inversion between the 9/2+ and 1/2− states is explained in terms of the role of neutron pairing correlations. Non-collective sequences of levels were delineated above the 9/2+ isomeric state. These are interpreted as being associated with a modest oblate deformation in the framework of Monte-Carlo shell-model calculations carried out with the A3DA-m Hamiltonian in the p f g 9 / 2 d 5 / 2 valence space. Similarities with the structure of Ni 40 28 68 were observed and the shape-coexistence mechanism in the N = 40 region of neutron-rich nuclei is discussed in terms of the so-called Type-II shell evolution, with an emphasis on proton–neutron correlations between valence nucleons, especially those involving the shape-driving g 9 / 2 neutron orbital.

Author(s): Titus, R; Ney, EM; Zegers, RGT; Bazin, D; Belarge, J; Bender, PC; Brown, BA; Campbell, CM; Elman, B; Engel, J; Gade, A; Gao, B; Kwan, E; Lipschutz, S; Longfellow, B; Lunderberg, E; Mijatovic, T; Noji, S; Pereira, J; Schmitt, J; Sullivan, C; Weisshaar, D; Zamora, JC | Abstract: Background: In the late stages of stellar core collapse just prior to core bounce, electron captures on medium-heavy nuclei drive deleptonization. Therefore, simulations require the use of accurate reaction rates. Nuclei with neutron number near N=50 above atomic number Z=28 play an important role. Rates presently used in astrophysical simulations rely primarily on a relatively simple single-state approximation. In order to improve the accuracy of the astrophysical simulations, experimental data are needed to test the electron-capture rates and to guide the development of better theoretical models and astrophysical simulations. Purpose: The purpose of the present work was to measure the Gamow-Teller transition strength from Kr86 to Br86, to derive the stellar electron-capture rates based on the extracted strengths, and to compare the derived rates with rates based on shell-model and quasiparticle random-phase approximation (QRPA) Gamow-Teller strengths calculations, as well as the single-state approximation. An additional purpose was to test the impact of using improved electron-capture rates on the late evolution of core-collapse supernovae. Method: The Gamow-Teller strengths from Kr86 were extracted from the Kr86(t,He3+γ) charge-exchange reaction at 115MeV/u. The electron-capture rates were calculated as a function of stellar density and temperature. Besides the case of Kr86, the electron-capture rates based on the QRPA calculations were calculated for 78 additional isotopes near N=50 above Z=28. The impact of using these rates instead of those based on the single-state approximation is studied in a spherically symmetrical simulation of core collapse just prior to bounce. Results: The derived electron-capture rates on Kr86 from the experimental Gamow-Teller strength distribution are much smaller than the rates estimated based on the single-state approximation. Rates based on Gamow-Teller strengths estimated in shell-model and QRPA calculations are more accurate. The core-collapse supernova simulation with electron-capture rates based on the QRPA calculations indicate a significant reduction in the deleptonization during the collapse phase. Conclusions: It is important to utilize microscopic theoretical models that are tested by experimental data to constrain and estimate Gamow-Teller strengths and derived electron-capture rates for nuclei near N=50 that are inputs for astrophysical simulations of core-collapse supernovae and their multimessenger signals, such as the emission of neutrinos and gravitational waves.

The development of advanced γ-ray tracking arrays allows for a sensitive new technique to investigate elusive states of exotic nuclei with fast rare-isotope beams. By taking advantage of the excellent energy and position resolution of the Gamma-Ray Energy Tracking In-beam Nuclear Array, we developed a novel technique to identify in-flight isomeric decays of the 0⁺₂ state in 32Mg populated in a two-proton removal reaction. We confirm the 0⁺₂→2+1γ-ray transition of ³²Mg and constrain the 0⁺₂ decay lifetime, suggesting a large collectivity. The small partial cross section populating the 0⁺₂ state in this reaction provides experimental evidence for the reduced occupancy of the normal configuration of the 0⁺₂ state, indicating the intruder dominance of this state.

Author(s): Elman, B; Gade, A; Janssens, RVF; Ayangeakaa, AD; Bazin, D; Belarge, J; Bender, PC; Brown, BA; Campbell, CM; Carpenter, MP; Crawford, HL; Crider, BP; Fallon, P; Forney, AM; Harker, J; Liddick, SN; Longfellow, B; Lunderberg, E; Prokop, CJ; Sethi, J; Taniuchi, R; Walters, WB; Weisshaar, D; Zhu, S | Abstract: The neutron-rich Ni isotopes have attracted attention in recent years because of the occurrence of shape or configuration coexistence. We report on the difference in population of excited final states in Ni70 following γ-ray tagged one-proton, one-neutron, and two-proton knockout from Cu71, Ni71, and Zn72 rare-isotope beams, respectively. Using variations observed in the relative transition intensities, signaling the changed population of specific final states in the different reactions, the role of neutron and proton configurations in excited states of Ni70 is probed schematically, with the goal of identifying those that carry, as leading configuration, proton excitations across the Z=28 shell closure. Such states are suggested in the literature to form a collective structure associated with prolate deformation. Adding to the body of knowledge for Ni70, 29 new transitions are reported, of which 15 are placed in its level scheme.

A more detailed test of the implementation of nuclear forces that drive shell evolution in the pivotal nucleus ^{42}Si-going beyond earlier comparisons of excited-state energies-is important. The two leading shell-model effective interactions, SDPF-MU and SDPF-U-Si, both of which reproduce the low-lying ^{42}Si(2_{1}^{+}) energy, but whose predictions for other observables differ significantly, are interrogated by the population of states in neutron-rich ^{42}Si with a one-proton removal reaction from ^{43}P projectiles at 81 MeV/nucleon. The measured cross sections to the individual ^{42}Si final states are compared to calculations that combine eikonal reaction dynamics with these shell-model nuclear structure overlaps. The differences in the two shell-model descriptions are examined and linked to predicted low-lying excited 0^{+} states and shape coexistence. Based on the present data, which are in better agreement with the SDPF-MU calculations, the state observed at 2150(13) keV in ^{42}Si is proposed to be the (0_{2}^{+}) level.

We present a high-resolution in-beam γ-ray spectroscopy study of excited states in the mirror nuclei 55Co and 56Ni following one-nucleon knockout from a projectile beam of 56Ni. The newly determined partial cross sections and the γ-decay properties of excited states provide a test of state-of-the-art nuclear structure models and probe mirror symmetry in unique ways. The new experimental data are compared to large-scale shell-model calculations in the full pf space and including charge-dependent contributions. A mirror asymmetry for the partial cross sections leading to the two lowest 3/2− states in the A = 55 mirror pair was identified as well as a significant difference in the E1 decays from the 1/21+ state to the same two 3/2− states. The mirror asymmetry in the partial cross sections cannot be reconciled with the present shell-model picture or small mixing introduced in a two-state model. The observed mirror asymmetry in the E decay pattern, however, points at stronger mixing between the two lowest 3/2− states in 55Co than in its mirror 55Ni.

A more detailed test of the implementation of nuclear forces that drive shell evolution in the pivotal nucleus ^{42}Si-going beyond earlier comparisons of excited-state energies-is important. The two leading shell-model effective interactions, SDPF-MU and SDPF-U-Si, both of which reproduce the low-lying ^{42}Si(2_{1}^{+}) energy, but whose predictions for other observables differ significantly, are interrogated by the population of states in neutron-rich ^{42}Si with a one-proton removal reaction from ^{43}P projectiles at 81 MeV/nucleon. The measured cross sections to the individual ^{42}Si final states are compared to calculations that combine eikonal reaction dynamics with these shell-model nuclear structure overlaps. The differences in the two shell-model descriptions are examined and linked to predicted low-lying excited 0^{+} states and shape coexistence. Based on the present data, which are in better agreement with the SDPF-MU calculations, the state observed at 2150(13) keV in ^{42}Si is proposed to be the (0_{2}^{+}) level.

The superfluid tunneling model is applied to the calculation of half-lives of the observed α decays in N=84 isotones. Results of our calculations are compared to experimental data on the ground-state α decays along the isotonic chain from 144Nd to 159Re. Good agreement is found. The α decays of the known high-spin isomers in 155Lu, 156Hf, 157Ta, and 158W are also well reproduced, once a reduction in the pairing strength is taken into account. This includes reproduction of the main features of the recently observed fine structure from 155Lu (25/2-) and 156Hf (8+). Predictions for the α-decay fine structure of 157Ta (25/2-) and 158W (8+) high-spin isomers are presented.

Covid-19 has influenced the investment environment throughout the world, including in Indonesia, by influencing the financial cycle (interest rates and exchange rates). This research aims to determine changes in the investment environment influenced by changes in interest rates and exchange rates in Indonesia. The novelty of this research is because there is relevance to economic conditions around the world, measurement techniques use several methods of measuring the financial waves to determine accurately changes in the investment environment, the measurement results are presented using a quantitative approach. The type of data used is secondary data obtained from the official website of Bank Indonesia and several related agencies such as interest rates, exchange rates and investments from 2019- 2020Q2. This research uses multiple linear regression, using IBM SPSS 23, for significant results through variable relationships. The results of this research indicate that partially the interest rate and exchange rate has a positive and significant effect, while the interest rate and the exchange rate simultaneously have a significant effect on investment. The implications of this research show that Indonesia is a good investment environment, despite financial fluctuations due to the Covid-19 pandemic.

The purpose of this article is to provide guidelines for determining a Significant Noise-Induced Threshold Shift in clinical trials involving human populations. The article reviews recommendations for the standards to be referenced for human subjects, equipment, test environment, and personnel. Additional guidelines for military populations are provided. Guidelines for the calibration of audiometers, sound booth noise levels, and immitance equipment are provided. In addition the guidance provides specific suggestions for the subjects history before study onset, and otoscopy.Test frequencies for threshold determination and methods of threshold determination are reviewed for both air conduction and bone conduction for both baseline testing and later determination of either a temporary (TTS) or permanent threshold shift (PTS). Once a Significant Noise-Induced Threshold Shift has been determined, subjects should be retested, conductive component should be ruled out or addressed, and the subject should be counseled or referred for additional medical evaluation. Guidance for reporting procedures and the computerized study database are described. Finally, experimental designs suggested for noise-induced otoprotection clinical trials are described.

Test D-methionine (D-met) as an otoprotectant from kanamycin-induced ototoxicity and determine the lowest maximally protective D-met dose.Auditory brainstem responses (ABR) were measured at 4, 8, 14, and 20 kHz at baseline and two, four, and six weeks after kanamycin and D-met administration initiation. ABR threshold shifts assessed auditory function. Following six-week ABR testing, animals were decapitated and cochleae collected for outer hair cell (OHC) quantification.Eight groups of 10 male pigmented guinea pigs were administered a subcutaneous kanamycin (250 mg/kg/dose) injection once per day and an intraperitoneal D-met injection (0 (saline), 120, 180, 240, 300, 360, 420, or 480 mg/kg/day) twice per day for 23 days.Significant ABR threshold shift reductions and increased OHC counts (p ≤ 0.01) were measured at multiple D-met-dosed groups starting at two-week ABR assessments. A 300 mg/kg/day optimal otoprotective D-met dose provided 34-41 dB ABR threshold shift reductions and OHC protection. Lesser, but significant, D-met otoprotection was measured at lower and higher D-met doses.D-met significantly reduced ABR threshold shifts and increased OHC percentages compared to kanamycin-treated controls. Results may be clinically significant particularly for multidrug-resistant tuberculosis patients who frequently suffer from kanamycin-induced hearing loss in developing countries.

One of the most exotic light neutron-rich nuclei currently accessible for experimental study is ^{40}Mg, which lies at the intersection of the nucleon magic number N=28 and the neutron drip line. Low-lying excited states of ^{40}Mg have been studied for the first time following a one-proton removal reaction from ^{41}Al, performed at the Radioactive Isotope Beam Factory of RIKEN Nishina Center with the DALI2 γ-ray array and the ZeroDegree spectrometer. Two γ-ray transitions were observed, suggesting an excitation spectrum that shows unexpected properties as compared to both the systematics along the Z=12, N≥20 Mg isotopes and available state-of-the-art theoretical model predictions. A possible explanation for the observed structure involves weak-binding effects in the low-lying excitation spectrum.

Recent results from RIKEN/RIBF on the low-lying level structure of 29F are interpreted within the Particle-Rotor Model. We show that the experimental data can be understood in the Rotation-aligned Coupling Scheme, with the 5/2+ ground state as the bandhead of a decoupled band. In this picture, the energy of the observed 1/2+1 state correlates strongly with the rotational energy of the core and provides an estimate of the 2+ energy in 28O. Our analysis suggest a moderate deformation, epsilon_2 ~ 0.17, and places the 2+ in 28O at ~ 2.4 MeV., Comment: 3 pages, 3 figures, To be submitted to Phys. Lett. B

© 2017 Elsevier B.V. We have characterized, for the first time, an n-type segmented inverted coaxial point-contact detector. This novel detector technology relies on a large variation in drift time of the majority charge carriers, as well as image and net charges observed on the segments, to achieve a potential γ-ray interaction position resolution of better than 1 mm. However, the intrinsic energy resolution in this detector is poor (more than 20 keV at 1332 keV) because of charge (electron) trapping effects. We propose an algorithm that enables restoration of the resolution to a value of 3.44 ± 0.03 keV at 1332 keV for events with a single interaction. The algorithm is based on a measurement of the azimuthal angle and the electron drift time of a given event; the energy of the event is corrected as a function of these two values.

Author(s): Richard, AL; Crawford, HL; Fallon, P; Macchiavelli, AO; Bader, VM; Bazin, D; Bowry, M; Campbell, CM; Carpenter, MP; Clark, RM; Cromaz, M; Gade, A; Ideguchi, E; Iwasaki, H; Jones, MD; Langer, C; Lee, IY; Loelius, C; Lunderberg, E; Morse, C; Rissanen, J; Salathe, M; Smalley, D; Stroberg, SR; Weisshaar, D; Whitmore, K; Wiens, A; Williams, SJ; Wimmer, K; Yamamato, T | Abstract: The "island of inversion" at N≈20 for the neon, sodium, and magnesium isotopes has long been an area of interest both experimentally and theoretically due to the subtle competition between 0p-0h and np-nh configurations leading to deformed shapes. However, the presence of rotational band structures, which are fingerprints of deformed shapes, have only recently been observed in this region. In this work, we report on a measurement of the low-lying level structure of Mg33 populated by a two-stage projectile fragmentation reaction and studied with the Gamma Ray Energy Tracking In-Beam Nuclear Array (GRETINA). The experimental level energies, ground-state magnetic moment, intrinsic quadrupole moment, and γ-ray intensities show good agreement with the strong-coupling limit of a rotational model.

Background The purpose of this study was to test if oral D-methionine (D-met) reduced mucositis during chemoradiotherapy. Methods We conducted a placebo-controlled double-blind randomized phase II trial of D-met (100 mg/kg p.o. b.i.d.) testing the rate of severe (grades 3-4) mucositis. Results Sixty patients were randomized. Grade 2 + oral pain was higher with placebo (79% vs 45%; P = .0165), whereas grade 2 + body odor was greater with D-met (3% vs 41%; P = .0015). Mucositis was decreased with D-met by the physician (World Health Organization [WHO], P = .007; Radiation Therapy Oncology Group [RTOG], P = .009) and patient functional scales (RTOG, P = .0023). The primary end point of grades 3 to 4 mucositis on the composite scale demonstrated a decrease with D-met (48% vs 24%; P = .058), which was borderline in significance. A planned secondary analysis of a semiquantitative scoring system noted decreased oral ulceration (2.2 vs 1.5; P = .023) and erythema (1.6 vs 1.1; P = .048) with D-met. Conclusion Although not meeting the primary end point, results of multiple assessments suggest that D-met decreased mucositis.

The calcium isotopes have emerged as a critical testing ground for new microscopically derived shell-model interactions, and a great deal of experimental and theoretical focus has been directed toward this region. We investigate the relative spectroscopic strengths associated with 1f7/2 neutron hole states in Ca47,49 following one-neutron knockout reactions from Ca48,50. The observed reduction of strength populating the 7/21- state in Ca49, as compared to Ca47, is inconsistent with shell-model calculations using both phenomenological interactions such as GXPF1, and interactions derived from microscopically based two- and three-nucleon forces. The result suggests a fragmentation of the l=3 strength to higher-lying states as suggested by the microscopic calculations, but the observed magnitude of the reduction is not reproduced in any shell-model description.

International audience; Neutron-rich isotopes are an important source of new information on nuclear physics. Specifically, the spin-isospin components in the nucleon-nucleon (NN) interaction, e.g., the proton-neutron tensor force, are expected to modify shell structure in exotic nuclei. These potential changes in the intrinsic shell structure are of fundamental interest. The study of the excitation energy of states corresponding to specific configurations in even-even isotopes, together with the single-particle character of the first excited states of odd-A, neutron-rich Ni isotopes, probes the evolution of the neutron orbitals around the Fermi surface as a function of the neutron number a step forward in the understanding of the region and the nature of the NN interaction at large N/Z ratios. In an experiment carried out at the National Superconducting Cyclotron Laboratory [1], new spectroscopic information was obtained for 68Ni and the distribution of single-particle strengths in 67,69Ni was characterized by means of single-neutron knockout from 68,70Ni secondary beams. The spectroscopic strengths, deduced from the measured partial cross sections to the individual states tagged by their de-exciting gamma rays, is used to identify and quantify configurations that involve neutron excitations across the N = 40 harmonic oscillator shell closure. The de-excitation γ rays were measured with the GRETINA tracking array [2]. The results challenge the validity of the most current shell-model Hamiltonians and effective interactions, highlighting shortcomings that cannot yet be explained. These results suggest that our understanding of the low-energy states in such nuclei is not complete and requires further investigation.

The (10Be,10B [1.74 MeV]) charge-exchange reaction at 100 AMeV is presented as a new probe for isolating the isovector (ΔT = 1) non-spin-transfer (ΔS = 0) response of nuclei, with 28Si being the rst nucleus studied. By using a secondary 10Be beam produced by fast fragmentation of 18O nuclei at the NSCL Coupled Cyclotron Facility, applying the dispersion-matching technique with the S800 magnetic spectrometer to determine the excitation energy in 28Al, and performing high- resolution -ray tracking with the Gamma-Ray Energy Tracking Array (GRETINA) to identify the 1022-keV ray associated with the decay from the 1.74-MeV T = 1 isobaric analog state in 10B, a ΔS = 0 excitation-energy spectrum in 28Al was extracted. Monopole and dipole contributions were determined through a multipole-decomposition analysis, and the isovector giant dipole (IVGDR) and monopole (IVGMR) resonances were identi ed. The results show that this probe is a powerful tool for studying the elusive IVGMR, which is of interest for performing stringent tests of modern density functional theories at high excitation energies and for constraining the bulk properties of nuclei and nuclear matter. The extracted distributions were compared with theoretical calculations based on the normal-modes formalism and the proton-neutron relativistic time-blocking approximation. Calculated cross sections based on these strengths underestimate the data by about a factor of two, which likely indicates de ciencies in the reaction calculations based on the distorted wave Born approximation.

Despite the more than 1 order of magnitude difference between the measured dipole moments in ^{144}Ba and ^{146}Ba, the octupole correlations in ^{146}Ba are found to be as strong as those in ^{144}Ba with a similarly large value of B(E3;3^{-}→0^{+}) determined as 48(+21-29) W.u. The new results not only establish unambiguously the presence of a region of octupole deformation centered on these neutron-rich Ba isotopes, but also manifest the dependence of the electric dipole moments on the occupancy of different neutron orbitals in nuclei with enhanced octupole strength, as revealed by fully microscopic calculations.

© 2016 Elsevier B.V. The sensitivity of the position resolution of the gamma-ray tracking array GRETINA to the hole charge-carrier mobility parameter is investigated. The χ2results from a fit of averaged signal (“superpulse”) data exhibit a shallow minimum for hole mobilities 15% lower than the currently adopted values. Calibration data on position resolution is analyzed, together with simulations that isolate the hole mobility dependence of signal decomposition from other effects such as electronics cross-talk. The results effectively exclude hole mobility as a dominant parameter for improving the position resolution for reconstruction of gamma-ray interaction points in GRETINA.

© 2016 Elsevier B.V. The γ-ray tracking array GRETINA was coupled to the S800 magnetic spectrometer for spectroscopy with fast beams of rare isotopes at the National Superconducting Cyclotron Laboratory on the campus of Michigan State University. We describe the technical details of this powerful setup and report on GRETINA's performance achieved with source and in-beam measurements. The γ-ray multiplicity encountered in experiments with fast beams is usually low, allowing for a simplified and efficient treatment of the data in the γ-ray analysis in terms of Doppler reconstruction and spectral quality. The results reported in this work were obtained from GRETINA consisting of 8 detector modules hosting four high-purity germanium crystals each. Currently, GRETINA consists of 10 detector modules.

This study tested multiple dosing epochs of pre-loaded D-methionine (D-met) for otoprotection from noise-induced hearing loss (NIHL).Auditory brainstem response (ABR) thresholds were measured at baseline, 1 day, and 21 days following a 6-hour 105 dB sound pressure level (SPL) octave band noise (OBN) exposure. Outer hair cell (OHC) counts were measured after day 21 sacrifice.Three groups of five Chinchillas laniger each were given a 2-day regimen comprising five doses of D-met (200 mg/kg/dose) intraperitoneally (IP) starting 2, 2.5, or 3 days prior to noise exposure. A control group (n = 5) received five doses of equivalent volume saline IP starting 2.5 days prior to noise exposure.ABR threshold shifts from baseline to day-21 post-noise exposure were reduced in all D-met groups versus controls, reaching significance (p0.05) in the 3-day group. D-met groups showed reduced OHC loss relative to controls at day-21 post-noise exposure, reaching significance (p0.05) at all frequency regions in the 3-day group and at the 2, 4, and 8 kHz frequency regions in the 2.5-day group.D-met administration in advance of noise-exposure, without further administration, significantly protects from noise-induced ABR threshold shift and OHC loss.

The Gamma-Ray Energy Tracking In-beam Nuclear Array (GRETINA) is a new generation high-resolution γ - ray spectrometer consisting of electrically segmented high-purity germanium crystals. GRETINA is capable of reconstructing the energy and position of each γ - ray interaction point inside the crystal with high resolution. This enables γ - ray energy tracking which in turn provides an array with large photopeak efficiency, high resolution and good peak-to-total ratio. GRETINA is used for nuclear structure studies with demanding γ - ray detection requirements and it is suitable for experiments with radioactive-ion beams with high recoil velocities. The GRETINA array has a 1 π solid angle coverage and constitutes the first stage towards the full 4 π array GRETA. We present in this paper the main parts and the performance of the GRETINA system.