Author: "C. Kraus" - Searchworks@Jio Institute Digital Library Search Results

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946 results on '"C. Kraus"'

1. The OPTIMIZE patient- and family-centered, primary care-based deprescribing intervention for older adults with dementia or mild cognitive impairment and multiple chronic conditions: study protocol for a pragmatic cluster randomized controlled trial

Author: E. A. Bayliss, S. M. Shetterly, M. L. Drace, J. Norton, A. R. Green, E. Reeve, L. A. Weffald, L. Wright, M. L. Maciejewski, O. C. Sheehan, J. L. Wolff, K. S. Gleason, C. Kraus, M. Maiyani, M. Du Vall, and C. M. Boyd
Subjects: Polypharmacy, Multimorbidity, Deprescribing, Dementia, Medicine (General), R5-920
Abstract: Abstract Background Most individuals with dementia or mild cognitive impairment (MCI) have multiple chronic conditions (MCC). The combination leads to multiple medications and complex medication regimens and is associated with increased risk for significant treatment burden, adverse drug events, cognitive changes, hospitalization, and mortality. Optimizing medications through deprescribing (the process of reducing or stopping the use of inappropriate medications or medications unlikely to be beneficial) may improve outcomes for MCC patients with dementia or MCI. Methods With input from patients, family members, and clinicians, we developed and piloted a patient-centered, pragmatic intervention (OPTIMIZE) to educate and activate patients, family members, and primary care clinicians about deprescribing as part of optimal medication management for older adults with dementia or MCI and MCC. The clinic-based intervention targets patients on 5 or more medications, their family members, and their primary care clinicians using a pragmatic, cluster-randomized design at Kaiser Permanente Colorado. The intervention has two components: a patient/ family component focused on education and activation about the potential value of deprescribing, and a clinician component focused on increasing clinician awareness about options and processes for deprescribing. Primary outcomes are total number of chronic medications and total number of potentially inappropriate medications (PIMs). We estimate that approximately 2400 patients across 9 clinics will receive the intervention. A comparable number of patients from 9 other clinics will serve as wait-list controls. We have > 80% power to detect an average decrease of − 0.70 (< 1 medication). Secondary outcomes include the number of PIM starts, dose reductions for selected PIMs (benzodiazepines, opiates, and antipsychotics), rates of adverse drug events (falls, hemorrhagic events, and hypoglycemic events), ability to perform activities of daily living, and skilled nursing facility, hospital, and emergency department admissions. Discussion The OPTIMIZE trial will examine whether a primary care-based, patient- and family-centered intervention educating patients, family members, and clinicians about deprescribing reduces numbers of chronic medications and PIMs for older adults with dementia or MCI and MCC. Trial registration NCT03984396 . Registered on 13 June 2019
Published: 2020
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2. Theia: an advanced optical neutrino detector

Author: M. Askins, Z. Bagdasarian, N. Barros, E. W. Beier, E. Blucher, R. Bonventre, E. Bourret, E. J. Callaghan, J. Caravaca, M. Diwan, S. T. Dye, J. Eisch, A. Elagin, T. Enqvist, V. Fischer, K. Frankiewicz, C. Grant, D. Guffanti, C. Hagner, A. Hallin, C. M. Jackson, R. Jiang, T. Kaptanoglu, J. R. Klein, Yu. G. Kolomensky, C. Kraus, F. Krennrich, T. Kutter, T. Lachenmaier, B. Land, K. Lande, J. G. Learned, V. Lozza, L. Ludhova, M. Malek, S. Manecki, J. Maneira, J. Maricic, J. Martyn, A. Mastbaum, C. Mauger, F. Moretti, J. Napolitano, B. Naranjo, M. Nieslony, L. Oberauer, G. D. Orebi Gann, J. Ouellet, T. Pershing, S. T. Petcov, L. Pickard, R. Rosero, M. C. Sanchez, J. Sawatzki, S. H. Seo, M. Smiley, M. Smy, A. Stahl, H. Steiger, M. R. Stock, H. Sunej, R. Svoboda, E. Tiras, W. H. Trzaska, M. Tzanov, M. Vagins, C. Vilela, Z. Wang, J. Wang, M. Wetstein, M. J. Wilking, L. Winslow, P. Wittich, B. Wonsak, E. Worcester, M. Wurm, G. Yang, M. Yeh, E. D. Zimmerman, S. Zsoldos, and K. Zuber
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract New developments in liquid scintillators, high-efficiency, fast photon detectors, and chromatic photon sorting have opened up the possibility for building a large-scale detector that can discriminate between Cherenkov and scintillation signals. Such a detector could reconstruct particle direction and species using Cherenkov light while also having the excellent energy resolution and low threshold of a scintillator detector. Situated deep underground, and utilizing new techniques in computing and reconstruction, this detector could achieve unprecedented levels of background rejection, enabling a rich physics program spanning topics in nuclear, high-energy, and astrophysics, and across a dynamic range from hundreds of keV to many GeV. The scientific program would include observations of low- and high-energy solar neutrinos, determination of neutrino mass ordering and measurement of the neutrino CP-violating phase $$\delta $$ δ , observations of diffuse supernova neutrinos and neutrinos from a supernova burst, sensitive searches for nucleon decay and, ultimately, a search for neutrinoless double beta decay, with sensitivity reaching the normal ordering regime of neutrino mass phase space. This paper describes Theia, a detector design that incorporates these new technologies in a practical and affordable way to accomplish the science goals described above.
Published: 2020
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3. Neuroplastic effects of a selective serotonin reuptake inhibitor in relearning and retrieval

Author: M.B. Reed, T. Vanicek, R. Seiger, M. Klöbl, B. Spurny, P. Handschuh, V. Ritter, J. Unterholzner, G.M. Godbersen, G. Gryglewski, C. Kraus, D. Winkler, A. Hahn, and R. Lanzenberger
Subjects: Neuroplasticity, fMRI, SSRI, Learning, Insula, Angular gyrus, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract: Animal studies using selective serotonin reuptake inhibitors (SSRIs) and learning paradigms have demonstrated that serotonin is important for flexibility in executive functions and learning. SSRIs might facilitate relearning through neuroplastic processes and thus exert their clinical effects in psychiatric diseases where cognitive functioning is affected. However, translation of these mechanisms to humans is missing. In this randomized placebo-controlled trial, we assessed functional brain activation during learning and memory retrieval in healthy volunteers performing associative learning tasks aiming to translate facilitated relearning by SSRIs.To this extent, seventy-six participants underwent three MRI scanning sessions: (1) at baseline, (2) after three weeks of daily associative learning and subsequent retrieval (face-matching or Chinese character–noun matching) and (3) after three weeks of relearning under escitalopram (10 mg/day) or placebo. Associative learning and retrieval tasks were performed during each functional MRI (fMRI) session. Statistical modeling was done using a repeated-measures ANOVA, to test for content-by-treatment-by-time interaction effects.During the learning task, a significant substance-by-time interaction was found in the right insula showing a greater deactivation in the SSRI cohort after 21 days of relearning compared to the learning phase. In the retrieval task, there was a significant content-by-time interaction in the left angular gyrus (AG) with an increased activation in face-matching compared to Chinese-character matching for both learning and relearning phases. A further substance-by-time interaction was found in task performance after 21 days of relearning, indicating a greater decrease of performance in the placebo group.Our findings that escitalopram modulate insula activation demonstrates successful translation of relearning as a mechanism of SSRIs in human. Furthermore, we show that the left AG is an active component of correct memory retrieval, which coincides with previous literature. We extend the function of this region by demonstrating its activation is not only stimulus dependent but also time constrained. Finally, we were able to show that escitalopram aids in relearning, irrespective of content.
Published: 2021
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4. Search for non-resonant Higgs boson pair production in final states with leptons, taus, and photons in pp collisions at s $$ \sqrt{s} $$ = 13 TeV with the ATLAS detector

Author: The ATLAS collaboration, G. Aad, E. Aakvaag, B. Abbott, S. Abdelhameed, K. Abeling, N. J. Abicht, S. H. Abidi, M. Aboelela, A. Aboulhorma, H. Abramowicz, H. Abreu, Y. Abulaiti, B. S. Acharya, A. Ackermann, C. Adam Bourdarios, L. Adamczyk, S. V. Addepalli, M. J. Addison, J. Adelman, A. Adiguzel, T. Adye, A. A. Affolder, Y. Afik, M. N. Agaras, J. Agarwala, A. Aggarwal, C. Agheorghiesei, F. Ahmadov, W. S. Ahmed, S. Ahuja, X. Ai, G. Aielli, A. Aikot, M. Ait Tamlihat, B. Aitbenchikh, M. Akbiyik, T. P. A. Åkesson, A. V. Akimov, D. Akiyama, N. N. Akolkar, S. Aktas, K. Al Khoury, G. L. Alberghi, J. Albert, P. Albicocco, G. L. Albouy, S. Alderweireldt, Z. L. Alegria, M. Aleksa, I. N. Aleksandrov, C. Alexa, T. Alexopoulos, F. Alfonsi, M. Algren, M. Alhroob, B. Ali, H. M. J. Ali, S. Ali, S. W. Alibocus, M. Aliev, G. Alimonti, W. Alkakhi, C. Allaire, B. M. M. Allbrooke, J. F. Allen, C. A. Allendes Flores, P. P. Allport, A. Aloisio, F. Alonso, C. Alpigiani, Z. M. K. Alsolami, M. Alvarez Estevez, A. Alvarez Fernandez, M. Alves Cardoso, M. G. Alviggi, M. Aly, Y. Amaral Coutinho, A. Ambler, C. Amelung, M. Amerl, C. G. Ames, D. Amidei, K. J. Amirie, S. P. Amor Dos Santos, K. R. Amos, S. An, V. Ananiev, C. Anastopoulos, T. Andeen, J. K. Anders, A. C. Anderson, S. Y. Andrean, A. Andreazza, S. Angelidakis, A. Angerami, A. V. Anisenkov, A. Annovi, C. Antel, E. Antipov, M. Antonelli, F. Anulli, M. Aoki, T. Aoki, M. A. Aparo, L. Aperio Bella, C. Appelt, A. Apyan, S. J. Arbiol Val, C. Arcangeletti, A. T. H. Arce, E. Arena, J-F. Arguin, S. Argyropoulos, J.-H. Arling, O. Arnaez, H. Arnold, G. Artoni, H. Asada, K. Asai, S. Asai, N. A. Asbah, R. A. Ashby Pickering, K. Assamagan, R. Astalos, K. S. V. Astrand, S. Atashi, R. J. Atkin, M. Atkinson, H. Atmani, P. A. Atmasiddha, K. Augsten, S. Auricchio, A. D. Auriol, V. A. Austrup, G. Avolio, K. Axiotis, G. Azuelos, D. Babal, H. Bachacou, K. Bachas, A. Bachiu, F. Backman, A. Badea, T. M. Baer, P. Bagnaia, M. Bahmani, D. Bahner, K. Bai, J. T. Baines, L. Baines, O. K. Baker, E. Bakos, D. Bakshi Gupta, L. E. Balabram Filho, V. Balakrishnan, R. Balasubramanian, E. M. Baldin, P. Balek, E. Ballabene, F. Balli, L. M. Baltes, W. K. Balunas, J. Balz, I. Bamwidhi, E. Banas, M. Bandieramonte, A. Bandyopadhyay, S. Bansal, L. Barak, M. Barakat, E. L. Barberio, D. Barberis, M. Barbero, M. Z. Barel, K. N. Barends, T. Barillari, M-S. Barisits, T. Barklow, P. Baron, D. A. Baron Moreno, A. Baroncelli, G. Barone, A. J. Barr, J. D. Barr, F. Barreiro, J. Barreiro Guimarães da Costa, U. Barron, M. G. Barros Teixeira, S. Barsov, F. Bartels, R. Bartoldus, A. E. Barton, P. Bartos, A. Basan, M. Baselga, A. Bassalat, M. J. Basso, S. Bataju, R. Bate, R. L. Bates, S. Batlamous, B. Batool, M. Battaglia, D. Battulga, M. Bauce, M. Bauer, P. Bauer, L. T. Bazzano Hurrell, J. B. Beacham, T. Beau, J. Y. Beaucamp, P. H. Beauchemin, P. Bechtle, H. P. Beck, K. Becker, A. J. Beddall, V. A. Bednyakov, C. P. Bee, L. J. Beemster, T. A. Beermann, M. Begalli, M. Begel, A. Behera, J. K. Behr, J. F. Beirer, F. Beisiegel, M. Belfkir, G. Bella, L. Bellagamba, A. Bellerive, P. Bellos, K. Beloborodov, D. Benchekroun, F. Bendebba, Y. Benhammou, K. C. Benkendorfer, L. Beresford, M. Beretta, E. Bergeaas Kuutmann, N. Berger, B. Bergmann, J. Beringer, G. Bernardi, C. Bernius, F. U. Bernlochner, F. Bernon, A. Berrocal Guardia, T. Berry, P. Berta, A. Berthold, S. Bethke, A. Betti, A. J. Bevan, N. K. Bhalla, S. Bhatta, D. S. Bhattacharya, P. Bhattarai, K. D. Bhide, V. S. Bhopatkar, R. M. Bianchi, G. Bianco, O. Biebel, R. Bielski, M. Biglietti, C. S. Billingsley, M. Bindi, A. Bingul, C. Bini, A. Biondini, G. A. Bird, M. Birman, M. Biros, S. Biryukov, T. Bisanz, E. Bisceglie, J. P. Biswal, D. Biswas, I. Bloch, A. Blue, U. Blumenschein, J. Blumenthal, V. S. Bobrovnikov, M. Boehler, B. Boehm, D. Bogavac, A. G. Bogdanchikov, C. Bohm, V. Boisvert, P. Bokan, T. Bold, M. Bomben, M. Bona, M. Boonekamp, C. D. Booth, A. G. Borbély, I. S. Bordulev, H. M. Borecka-Bielska, G. Borissov, D. Bortoletto, D. Boscherini, M. Bosman, J. D. Bossio Sola, K. Bouaouda, N. Bouchhar, L. Boudet, J. Boudreau, E. V. Bouhova-Thacker, D. Boumediene, R. Bouquet, A. Boveia, J. Boyd, D. Boye, I. R. Boyko, L. Bozianu, J. Bracinik, N. Brahimi, G. Brandt, O. Brandt, F. Braren, B. Brau, J. E. Brau, R. Brener, L. Brenner, R. Brenner, S. Bressler, G. Brianti, D. Britton, D. Britzger, I. Brock, G. Brooijmans, E. M. Brooks, E. Brost, L. M. Brown, L. E. Bruce, T. L. Bruckler, P. A. Bruckman de Renstrom, B. Brüers, A. Bruni, G. Bruni, M. Bruschi, N. Bruscino, T. Buanes, Q. Buat, D. Buchin, A. G. Buckley, O. Bulekov, B. A. Bullard, S. Burdin, C. D. Burgard, A. M. Burger, B. Burghgrave, O. Burlayenko, J. Burleson, J. T. P. Burr, J. C. Burzynski, E. L. Busch, V. Büscher, P. J. Bussey, J. M. Butler, C. M. Buttar, J. M. Butterworth, W. Buttinger, C. J. Buxo Vazquez, A. R. Buzykaev, S. Cabrera Urbán, L. Cadamuro, D. Caforio, H. Cai, Y. Cai, V. M. M. Cairo, O. Cakir, N. Calace, P. Calafiura, G. Calderini, P. Calfayan, G. Callea, L. P. Caloba, D. Calvet, S. Calvet, M. Calvetti, R. Camacho Toro, S. Camarda, D. Camarero Munoz, P. Camarri, M. T. Camerlingo, D. Cameron, C. Camincher, M. Campanelli, A. Camplani, V. Canale, A. C. Canbay, E. Canonero, J. Cantero, Y. Cao, F. Capocasa, M. Capua, A. Carbone, R. Cardarelli, J. C. J. Cardenas, G. Carducci, T. Carli, G. Carlino, J. I. Carlotto, B. T. Carlson, E. M. Carlson, J. Carmignani, L. Carminati, A. Carnelli, M. Carnesale, S. Caron, E. Carquin, S. Carrá, G. Carratta, A. M. Carroll, T. M. Carter, M. P. Casado, M. Caspar, F. L. Castillo, L. Castillo Garcia, V. Castillo Gimenez, N. F. Castro, A. Catinaccio, J. R. Catmore, T. Cavaliere, V. Cavaliere, N. Cavalli, L. J. Caviedes Betancourt, Y. C. Cekmecelioglu, E. Celebi, S. Cella, F. Celli, M. S. Centonze, V. Cepaitis, K. Cerny, A. S. Cerqueira, A. Cerri, L. Cerrito, F. Cerutti, B. Cervato, A. Cervelli, G. Cesarini, S. A. Cetin, D. Chakraborty, J. Chan, W. Y. Chan, J. D. Chapman, E. Chapon, B. Chargeishvili, D. G. Charlton, M. Chatterjee, C. Chauhan, Y. Che, S. Chekanov, S. V. Chekulaev, G. A. Chelkov, A. Chen, B. Chen, H. Chen, J. Chen, M. Chen, S. Chen, S. J. Chen, X. Chen, Y. Chen, C. L. Cheng, H. C. Cheng, S. Cheong, A. Cheplakov, E. Cheremushkina, E. Cherepanova, R. Cherkaoui El Moursli, E. Cheu, K. Cheung, L. Chevalier, V. Chiarella, G. Chiarelli, N. Chiedde, G. Chiodini, A. S. Chisholm, A. Chitan, M. Chitishvili, M. V. Chizhov, K. Choi, Y. Chou, E. Y. S. Chow, K. L. Chu, M. C. Chu, X. Chu, Z. Chubinidze, J. Chudoba, J. J. Chwastowski, D. Cieri, K. M. Ciesla, V. Cindro, A. Ciocio, F. Cirotto, Z. H. Citron, M. Citterio, D. A. Ciubotaru, A. Clark, P. J. Clark, N. Clarke Hall, C. Clarry, J. M. Clavijo Columbie, S. E. Clawson, C. Clement, Y. Coadou, M. Cobal, A. Coccaro, R. F. Coelho Barrue, R. Coelho Lopes De Sa, S. Coelli, B. Cole, J. Collot, P. Conde Muiño, M. P. Connell, S. H. Connell, E. I. Conroy, F. Conventi, H. G. Cooke, A. M. Cooper-Sarkar, F. A. Corchia, A. Cordeiro Oudot Choi, L. D. Corpe, M. Corradi, F. Corriveau, A. Cortes-Gonzalez, M. J. Costa, F. Costanza, D. Costanzo, B. M. Cote, J. Couthures, G. Cowan, K. Cranmer, D. Cremonini, S. Crépé-Renaudin, F. Crescioli, M. Cristinziani, M. Cristoforetti, V. Croft, J. E. Crosby, G. Crosetti, A. Cueto, H. Cui, Z. Cui, W. R. Cunningham, F. Curcio, J. R. Curran, P. Czodrowski, M. M. Czurylo, M. J. Da Cunha Sargedas De Sousa, J. V. Da Fonseca Pinto, C. Da Via, W. Dabrowski, T. Dado, S. Dahbi, T. Dai, D. Dal Santo, C. Dallapiccola, M. Dam, G. D’amen, V. D’Amico, J. Damp, J. R. Dandoy, D. Dannheim, M. Danninger, V. Dao, G. Darbo, S. J. Das, F. Dattola, S. D’Auria, A. D’avanzo, C. David, T. Davidek, I. Dawson, H. A. Day-hall, K. De, R. De Asmundis, N. De Biase, S. De Castro, N. De Groot, P. de Jong, H. De la Torre, A. De Maria, A. De Salvo, U. De Sanctis, F. De Santis, A. De Santo, J. B. De Vivie De Regie, D. V. Dedovich, J. Degens, A. M. Deiana, F. Del Corso, J. Del Peso, F. Del Rio, L. Delagrange, F. Deliot, C. M. Delitzsch, M. Della Pietra, D. Della Volpe, A. Dell’Acqua, L. Dell’Asta, M. Delmastro, P. A. Delsart, S. Demers, M. Demichev, S. P. Denisov, L. D’Eramo, D. Derendarz, F. Derue, P. Dervan, K. Desch, C. Deutsch, F. A. Di Bello, A. Di Ciaccio, L. Di Ciaccio, A. Di Domenico, C. Di Donato, A. Di Girolamo, G. Di Gregorio, A. Di Luca, B. Di Micco, R. Di Nardo, K. F. Di Petrillo, M. Diamantopoulou, F. A. Dias, T. Dias Do Vale, M. A. Diaz, F. G. Diaz Capriles, A. R. Didenko, M. Didenko, E. B. Diehl, S. Díez Cornell, C. Diez Pardos, C. Dimitriadi, A. Dimitrievska, J. Dingfelder, T. Dingley, I-M. Dinu, S. J. Dittmeier, F. Dittus, M. Divisek, F. Djama, T. Djobava, C. Doglioni, A. Dohnalova, J. Dolejsi, Z. Dolezal, K. Domijan, K. M. Dona, M. Donadelli, B. Dong, J. Donini, A. D’Onofrio, M. D’Onofrio, J. Dopke, A. Doria, N. Dos Santos Fernandes, P. Dougan, M. T. Dova, A. T. Doyle, M. A. Draguet, E. Dreyer, I. Drivas-koulouris, M. Drnevich, M. Drozdova, D. Du, T. A. du Pree, F. Dubinin, M. Dubovsky, E. Duchovni, G. Duckeck, O. A. Ducu, D. Duda, A. Dudarev, E. R. Duden, M. D’uffizi, L. Duflot, M. Dührssen, I. Duminica, A. E. Dumitriu, M. Dunford, S. Dungs, K. Dunne, A. Duperrin, H. Duran Yildiz, M. Düren, A. Durglishvili, B. L. Dwyer, G. I. Dyckes, M. Dyndal, B. S. Dziedzic, Z. O. Earnshaw, G. H. Eberwein, B. Eckerova, S. Eggebrecht, E. Egidio Purcino De Souza, L. F. Ehrke, G. Eigen, K. Einsweiler, T. Ekelof, P. A. Ekman, S. El Farkh, Y. El Ghazali, H. El Jarrari, A. El Moussaouy, V. Ellajosyula, M. Ellert, F. Ellinghaus, N. Ellis, J. Elmsheuser, M. Elsawy, M. Elsing, D. Emeliyanov, Y. Enari, I. Ene, S. Epari, P. A. Erland, D. Ernani Martins Neto, M. Errenst, M. Escalier, C. Escobar, E. Etzion, G. Evans, H. Evans, L. S. Evans, A. Ezhilov, S. Ezzarqtouni, F. Fabbri, L. Fabbri, G. Facini, V. Fadeyev, R. M. Fakhrutdinov, D. Fakoudis, S. Falciano, L. F. Falda Ulhoa Coelho, F. Fallavollita, G. Falsetti, J. Faltova, C. Fan, Y. Fan, Y. Fang, M. Fanti, M. Faraj, Z. Farazpay, A. Farbin, A. Farilla, T. Farooque, S. M. Farrington, F. Fassi, D. Fassouliotis, M. Faucci Giannelli, W. J. Fawcett, L. Fayard, P. Federic, P. Federicova, O. L. Fedin, M. Feickert, L. Feligioni, D. E. Fellers, C. Feng, M. Feng, Z. Feng, M. J. Fenton, L. Ferencz, R. A. M. Ferguson, S. I. Fernandez Luengo, P. Fernandez Martinez, M. J. V. Fernoux, J. Ferrando, A. Ferrari, P. Ferrari, R. Ferrari, D. Ferrere, C. Ferretti, D. Fiacco, F. Fiedler, P. Fiedler, A. Filipčič, E. K. Filmer, F. Filthaut, M. C. N. Fiolhais, L. Fiorini, W. C. Fisher, T. Fitschen, P. M. Fitzhugh, I. Fleck, P. Fleischmann, T. Flick, M. Flores, L. R. Flores Castillo, L. Flores Sanz De Acedo, F. M. Follega, N. Fomin, J. H. Foo, A. Formica, A. C. Forti, E. Fortin, A. W. Fortman, M. G. Foti, L. Fountas, D. Fournier, H. Fox, P. Francavilla, S. Francescato, S. Franchellucci, M. Franchini, S. Franchino, D. Francis, L. Franco, V. Franco Lima, L. Franconi, M. Franklin, G. Frattari, Y. Y. Frid, J. Friend, N. Fritzsche, A. Froch, D. Froidevaux, J. A. Frost, Y. Fu, S. Fuenzalida Garrido, M. Fujimoto, K. Y. Fung, E. Furtado De Simas Filho, M. Furukawa, J. Fuster, A. Gaa, A. Gabrielli, P. Gadow, G. Gagliardi, L. G. Gagnon, S. Gaid, S. Galantzan, E. J. Gallas, B. J. Gallop, K. K. Gan, S. Ganguly, Y. Gao, F. M. Garay Walls, B. Garcia, C. García, A. Garcia Alonso, A. G. Garcia Caffaro, J. E. García Navarro, M. Garcia-Sciveres, G. L. Gardner, R. W. Gardner, N. Garelli, D. Garg, R. B. Garg, J. M. Gargan, C. A. Garner, C. M. Garvey, V. K. Gassmann, G. Gaudio, V. Gautam, P. Gauzzi, J. Gavranovic, I. L. Gavrilenko, A. Gavrilyuk, C. Gay, G. Gaycken, E. N. Gazis, A. A. Geanta, C. M. Gee, A. Gekow, C. Gemme, M. H. Genest, A. D. Gentry, S. George, W. F. George, T. Geralis, P. Gessinger-Befurt, M. E. Geyik, M. Ghani, K. Ghorbanian, A. Ghosal, A. Ghosh, B. Giacobbe, S. Giagu, T. Giani, A. Giannini, S. M. Gibson, M. Gignac, D. T. Gil, A. K. 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Yang, Y. Yang, Z. Yang, W-M. Yao, H. Ye, J. Ye, S. Ye, X. Ye, Y. Yeh, I. Yeletskikh, B. Yeo, M. R. Yexley, T. P. Yildirim, P. Yin, K. Yorita, S. Younas, C. J. S. Young, C. Young, C. Yu, Y. Yu, J. Yuan, M. Yuan, R. Yuan, L. Yue, M. Zaazoua, B. Zabinski, E. Zaid, Z. K. Zak, T. Zakareishvili, S. Zambito, J. A. Zamora Saa, J. Zang, D. Zanzi, O. Zaplatilek, C. Zeitnitz, H. Zeng, J. C. Zeng, D. T. Zenger, O. Zenin, T. Ženiš, S. Zenz, S. Zerradi, D. Zerwas, M. Zhai, D. F. Zhang, J. Zhang, K. Zhang, L. Zhang, P. Zhang, R. Zhang, S. Zhang, T. Zhang, X. Zhang, Y. Zhang, Z. Zhang, H. Zhao, T. Zhao, Y. Zhao, Z. Zhao, A. Zhemchugov, J. Zheng, K. Zheng, X. Zheng, Z. Zheng, D. Zhong, B. Zhou, H. Zhou, N. Zhou, Y. Zhou, C. G. Zhu, J. Zhu, X. Zhu, Y. Zhu, X. Zhuang, K. Zhukov, N. I. Zimine, J. Zinsser, M. Ziolkowski, L. Živković, A. Zoccoli, K. Zoch, T. G. Zorbas, O. Zormpa, W. Zou, and L. Zwalinski
Subjects: Higgs Physics, Hadron-Hadron Scattering, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract A search is presented for non-resonant Higgs boson pair production, targeting the bbZZ, 4V (V = W or Z), VVττ, 4τ, γγVV and γγττ decay channels. Events are categorised based on the multiplicity of light charged leptons (electrons or muons), hadronically decaying tau leptons, and photons. The search is based on a data sample of proton-proton collisions at s $$ \sqrt{s} $$ = 13 TeV recorded with the ATLAS detector during Run 2 of the Large Hadron Collider, corresponding to an integrated luminosity of 140 fb −1. No evidence of the signal is found and the observed (expected) upper limit on the cross-section for non-resonant Higgs boson pair production is determined to be 17 (11) times the Standard Model predicted cross-section at 95% confidence level under the background-only hypothesis. The observed (expected) constraints on the HHH coupling modifier, κ λ , are determined to be −6.2 < κ λ < 11.6 (−4.5 < κ λ < 9.6) at 95% confidence level, assuming the Standard Model for the expected limits and that new physics would only affect κ λ .
Published: 2024
Full Text: View/download PDF

5. Combination of searches for Higgs boson decays into a photon and a massless dark photon using pp collisions at s $$ \sqrt{\textrm{s}} $$ = 13 TeV with the ATLAS detector

Author: The ATLAS collaboration, G. Aad, E. Aakvaag, B. Abbott, S. Abdelhameed, K. Abeling, N. J. Abicht, S. H. Abidi, M. Aboelela, A. Aboulhorma, H. Abramowicz, H. Abreu, Y. Abulaiti, B. S. Acharya, A. Ackermann, C. Adam Bourdarios, L. Adamczyk, S. V. Addepalli, M. J. Addison, J. Adelman, A. Adiguzel, T. Adye, A. A. Affolder, Y. Afik, M. N. Agaras, J. Agarwala, A. Aggarwal, C. Agheorghiesei, F. Ahmadov, W. S. Ahmed, S. Ahuja, X. Ai, G. Aielli, A. Aikot, M. Ait Tamlihat, B. Aitbenchikh, M. Akbiyik, T. P. A. Åkesson, A. V. Akimov, D. Akiyama, N. N. Akolkar, S. Aktas, K. Al Khoury, G. L. Alberghi, J. Albert, P. Albicocco, G. L. Albouy, S. Alderweireldt, Z. L. Alegria, M. Aleksa, I. N. Aleksandrov, C. Alexa, T. Alexopoulos, F. Alfonsi, M. Algren, M. Alhroob, B. Ali, H. M. J. Ali, S. Ali, S. W. Alibocus, M. Aliev, G. Alimonti, W. Alkakhi, C. Allaire, B. M. M. Allbrooke, J. F. Allen, C. A. Allendes Flores, P. P. Allport, A. Aloisio, F. Alonso, C. Alpigiani, Z. M. K. Alsolami, M. 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Yabsley, S. Yacoob, Y. Yamaguchi, E. Yamashita, H. Yamauchi, T. Yamazaki, Y. Yamazaki, J. Yan, S. Yan, Z. Yan, H. J. Yang, H. T. Yang, S. Yang, T. Yang, X. Yang, Y. Yang, Z. Yang, W-M. Yao, H. Ye, J. Ye, S. Ye, X. Ye, Y. Yeh, I. Yeletskikh, B. K. Yeo, M. R. Yexley, T. P. Yildirim, P. Yin, K. Yorita, S. Younas, C. J. S. Young, C. Young, C. Yu, Y. Yu, J. Yuan, M. Yuan, R. Yuan, L. Yue, M. Zaazoua, B. Zabinski, E. Zaid, Z. K. Zak, T. Zakareishvili, S. Zambito, J. A. Zamora Saa, J. Zang, D. Zanzi, O. Zaplatilek, C. Zeitnitz, H. Zeng, J. C. Zeng, D. T. Zenger, O. Zenin, T. Ženiš, S. Zenz, S. Zerradi, D. Zerwas, M. Zhai, D. F. Zhang, J. Zhang, K. Zhang, L. Zhang, P. Zhang, R. Zhang, S. Zhang, T. Zhang, X. Zhang, Y. Zhang, Z. Zhang, H. Zhao, T. Zhao, Y. Zhao, Z. Zhao, A. Zhemchugov, J. Zheng, K. Zheng, X. Zheng, Z. Zheng, D. Zhong, B. Zhou, H. Zhou, N. Zhou, Y. Zhou, C. G. Zhu, J. Zhu, X. Zhu, Y. Zhu, X. Zhuang, K. Zhukov, N. I. Zimine, J. Zinsser, M. Ziolkowski, L. Živković, A. Zoccoli, K. Zoch, T. G. Zorbas, O. Zormpa, W. Zou, and L. Zwalinski
Subjects: Hadron-Hadron Scattering, Higgs Physics, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract A combination of searches for Higgs boson decays into a visible photon and a massless dark photon (H → γγ d) is presented using 139 fb −1 of proton-proton collision data at a centre-of-mass energy of s $$ \sqrt{s} $$ = 13 TeV recorded by the ATLAS detector at the Large Hadron Collider. The observed (expected) 95% confidence level upper limit on the Standard Model Higgs boson decay branching ratio is determined to be B $$ \mathcal{B} $$ (H → γγ d) < 1.3% (1.5)%. The search is also sensitive to higher-mass Higgs bosons decaying into the same final state. The observed (expected) 95% confidence level limit on the cross-section times branching ratio ranges from 16 fb (20 fb) for m H = 400 GeV to 1.0 fb (1.5 fb) for m H = 3 TeV. Results are also interpreted in the context of a minimal simplified model.
Published: 2024
Full Text: View/download PDF

6. Search for heavy neutral Higgs bosons decaying into a top quark pair in 140 fb −1 of proton-proton collision data at s $$ \sqrt{s} $$ = 13 TeV with the ATLAS detector

Author: The ATLAS collaboration, G. Aad, E. Aakvaag, B. Abbott, S. Abdelhameed, K. Abeling, N. J. Abicht, S. H. Abidi, M. Aboelela, A. Aboulhorma, H. Abramowicz, H. Abreu, Y. Abulaiti, B. S. Acharya, A. Ackermann, C. Adam Bourdarios, L. Adamczyk, S. V. Addepalli, M. J. Addison, J. Adelman, A. Adiguzel, T. Adye, A. A. Affolder, Y. Afik, M. N. Agaras, J. Agarwala, A. Aggarwal, C. Agheorghiesei, A. Ahmad, F. Ahmadov, W. S. Ahmed, S. Ahuja, X. Ai, G. Aielli, A. Aikot, M. Ait Tamlihat, B. Aitbenchikh, M. Akbiyik, T. P. A. Åkesson, A. V. Akimov, D. Akiyama, N. N. Akolkar, S. Aktas, K. Al Khoury, G. L. Alberghi, J. Albert, P. Albicocco, G. L. Albouy, S. Alderweireldt, Z. L. Alegria, M. Aleksa, I. N. Aleksandrov, C. Alexa, T. Alexopoulos, F. Alfonsi, M. Algren, M. Alhroob, B. Ali, H. M. J. Ali, S. Ali, S. W. Alibocus, M. Aliev, G. Alimonti, W. Alkakhi, C. Allaire, B. M. M. Allbrooke, J. F. Allen, C. A. Allendes Flores, P. P. Allport, A. Aloisio, F. Alonso, C. Alpigiani, Z. M. K. Alsolami, M. 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Yorita, S. Younas, C. J. S. Young, C. Young, C. Yu, Y. Yu, J. Yuan, M. Yuan, R. Yuan, L. Yue, M. Zaazoua, B. Zabinski, E. Zaid, Z. K. Zak, T. Zakareishvili, N. Zakharchuk, S. Zambito, J. A. Zamora Saa, J. Zang, D. Zanzi, O. Zaplatilek, C. Zeitnitz, H. Zeng, J. C. Zeng, D. T. Zenger, O. Zenin, T. Ženiš, S. Zenz, S. Zerradi, D. Zerwas, M. Zhai, D. F. Zhang, J. Zhang, K. Zhang, L. Zhang, P. Zhang, R. Zhang, S. Zhang, T. Zhang, X. Zhang, Y. Zhang, Z. Zhang, H. Zhao, T. Zhao, Y. Zhao, Z. Zhao, A. Zhemchugov, J. Zheng, K. Zheng, X. Zheng, Z. Zheng, D. Zhong, B. Zhou, H. Zhou, N. Zhou, Y. Zhou, C. G. Zhu, J. Zhu, X. Zhu, Y. Zhu, X. Zhuang, K. Zhukov, N. I. Zimine, J. Zinsser, M. Ziolkowski, L. Živković, A. Zoccoli, K. Zoch, T. G. Zorbas, O. Zormpa, W. Zou, and L. Zwalinski
Subjects: Exotics, Hadron-Hadron Scattering, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract A search for heavy pseudo-scalar (A) and scalar (H) Higgs bosons decaying into a top-quark pair ( t t ¯ $$ t\overline{t} $$ ) has been performed with 140 fb −1 of proton-proton collision data collected by the ATLAS experiment at the Large Hadron Collider at a centre-of-mass energy of s $$ \sqrt{s} $$ = 13 TeV. Interference effects between the signal process and Standard Model (SM) t t ¯ $$ t\overline{t} $$ production are taken into account. Final states with exactly one or exactly two electrons or muons are considered. No significant deviation from the SM prediction is observed. The results of the search are interpreted in the context of a two-Higgs-doublet model (2HDM) of type II in the alignment limit with mass-degenerate pseudo-scalar and scalar Higgs bosons (m A = m H ) and the hMSSM parameterisation of the minimal supersymmetric extension of the Standard Model. Ratios of the two vacuum expectation values, tan β, smaller than 3.49 (3.16) are excluded at 95% confidence level for m A = m H = 400 GeV in the 2HDM (hMSSM). Masses up to 1240 GeV are excluded for the lowest tested tan β value of 0.4 in the 2HDM. In the hMSSM, masses up to 950 GeV are excluded for tan β = 1.0. In addition, generic exclusion limits are derived separately for single scalar and pseudo-scalar states for different choices of their mass and total width.
Published: 2024
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7. Current Status and Future Prospects of the SNO+ Experiment

Author: S. Andringa, E. Arushanova, S. Asahi, M. Askins, D. J. Auty, A. R. Back, Z. Barnard, N. Barros, E. W. Beier, A. Bialek, S. D. Biller, E. Blucher, R. Bonventre, D. Braid, E. Caden, E. Callaghan, J. Caravaca, J. Carvalho, L. Cavalli, D. Chauhan, M. Chen, O. Chkvorets, K. Clark, B. Cleveland, I. T. Coulter, D. Cressy, X. Dai, C. Darrach, B. Davis-Purcell, R. Deen, M. M. Depatie, F. Descamps, F. Di Lodovico, N. Duhaime, F. Duncan, J. Dunger, E. Falk, N. Fatemighomi, R. Ford, P. Gorel, C. Grant, S. Grullon, E. Guillian, A. L. Hallin, D. Hallman, S. Hans, J. Hartnell, P. Harvey, M. Hedayatipour, W. J. Heintzelman, R. L. Helmer, B. Hreljac, J. Hu, T. Iida, C. M. Jackson, N. A. Jelley, C. Jillings, C. Jones, P. G. Jones, K. Kamdin, T. Kaptanoglu, J. Kaspar, P. Keener, P. Khaghani, L. Kippenbrock, J. R. Klein, R. Knapik, J. N. Kofron, L. L. Kormos, S. Korte, C. Kraus, C. B. Krauss, K. Labe, I. Lam, C. Lan, B. J. Land, S. Langrock, A. LaTorre, I. Lawson, G. M. Lefeuvre, E. J. Leming, J. Lidgard, X. Liu, Y. Liu, V. Lozza, S. Maguire, A. Maio, K. Majumdar, S. Manecki, J. Maneira, E. Marzec, A. Mastbaum, N. McCauley, A. B. McDonald, J. E. McMillan, P. Mekarski, C. Miller, Y. Mohan, E. Mony, M. J. Mottram, V. Novikov, H. M. O’Keeffe, E. O’Sullivan, G. D. Orebi Gann, M. J. Parnell, S. J. M. Peeters, T. Pershing, Z. Petriw, G. Prior, J. C. Prouty, S. Quirk, A. Reichold, A. Robertson, J. Rose, R. Rosero, P. M. Rost, J. Rumleskie, M. A. Schumaker, M. H. Schwendener, D. Scislowski, J. Secrest, M. Seddighin, L. Segui, S. Seibert, T. Shantz, T. M. Shokair, L. Sibley, J. R. Sinclair, K. Singh, P. Skensved, A. Sörensen, T. Sonley, R. Stainforth, M. Strait, M. I. Stringer, R. Svoboda, J. Tatar, L. Tian, N. Tolich, J. Tseng, H. W. C. Tseung, R. Van Berg, E. Vázquez-Jáuregui, C. Virtue, B. von Krosigk, J. M. G. Walker, M. Walker, O. Wasalski, J. Waterfield, R. F. White, J. R. Wilson, T. J. Winchester, A. Wright, M. Yeh, T. Zhao, and K. Zuber
Subjects: Physics, QC1-999
Abstract: SNO+ is a large liquid scintillator-based experiment located 2 km underground at SNOLAB, Sudbury, Canada. It reuses the Sudbury Neutrino Observatory detector, consisting of a 12 m diameter acrylic vessel which will be filled with about 780 tonnes of ultra-pure liquid scintillator. Designed as a multipurpose neutrino experiment, the primary goal of SNO+ is a search for the neutrinoless double-beta decay (0νββ) of 130Te. In Phase I, the detector will be loaded with 0.3% natural tellurium, corresponding to nearly 800 kg of 130Te, with an expected effective Majorana neutrino mass sensitivity in the region of 55–133 meV, just above the inverted mass hierarchy. Recently, the possibility of deploying up to ten times more natural tellurium has been investigated, which would enable SNO+ to achieve sensitivity deep into the parameter space for the inverted neutrino mass hierarchy in the future. Additionally, SNO+ aims to measure reactor antineutrino oscillations, low energy solar neutrinos, and geoneutrinos, to be sensitive to supernova neutrinos, and to search for exotic physics. A first phase with the detector filled with water will begin soon, with the scintillator phase expected to start after a few months of water data taking. The 0νββ Phase I is foreseen for 2017.
Published: 2016
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8. Development of a comparative health systems global pharmacy fellowship

Author: T. Seys Ranola, C. Kraus, and L. DiPrete Brown
Subjects: Infectious and parasitic diseases, RC109-216, Public aspects of medicine, RA1-1270
Published: 2016
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9. Pesticide Mode of Action Classification: Understanding Resistance Action Committees (RACs)

Author: Emily C. Kraus and Brett Bultemeier
Subjects: mechanism of action, resistance management, pesticide resistance, FRAC, HRAC, IRAC, Agriculture (General), S1-972, Plant culture, SB1-1110, Biology (General), QH301-705.5
Abstract: This publication defines the concept of a pesticide mode of action and provides several examples. It emphasizes the importance of identifying and differentiating modes of action for pesticide resistance management. To this end, it defines the development and goals of the three Resistance Action Committees for insecticides (IRAC), herbicides (HRAC), and fungicides (FRAC) and describes each group’s pesticide mode of action classification scheme. Finally, it provides an example of a pesticide label and instructs applicators on how to rotate pesticides to manage resistance. This publication presents the subject matter in a concise manner and directs pesticide applicators to the very useful RAC Mode of Action group numbers for rotation purposes.
Published: 2024

10. Integrated pest management goes hand-in-hand with safety

Author: Emily C. Kraus
Subjects: biological control, integrated pest management, pesticide safety and handling, Agriculture (General), S1-972, Plant culture, SB1-1110, Biology (General), QH301-705.5
Abstract: This publication is geared toward pest management specialists, certified pesticide applicators, and homeowners who are managing indoor and outdoor pests. It provides a broad definition of a pest and describes integrated pest management (IPM) and pest management strategies. As opposed to other EDIS which are specific to management areas (ex: landscape, turf, vegetable) this publication can be used as a basis for all sectors of pest management. The publication also emphasizes using IPM to reduce the development of pesticide resistance and emphasizes how each aspect of IPM contributes to personal and environmental safety.
Published: 2024

11. Patient Satisfaction and Pain Relief After Deep Peroneal Nerve Neurectomy for Midfoot Arthritis: A Preliminary Short Report

Author: Jose M. Iturregui, Edward T. Haupt, Benjamin K. Wilke, Jonathan C. Kraus, and Glenn G. Shi
Subjects: Orthopedics and Sports Medicine, Surgery
Abstract: Background: The deep peroneal nerve (DPN) plays a role in afferent nociceptive dorsal midfoot joint pain perception. DPN neurectomy for treatment of symptomatic dorsal midfoot osteoarthritis allows early mobilization and weightbearing. The purpose of our study was to evaluate the patient satisfaction and pain relief after DPN neurectomy for treatment of chronic dorsal midfoot pain due to osteoarthritis. Methods: In this retrospective, IRB-approved, questionnaire-based study, we evaluated 48 patients (55 feet) with an average follow-up of 35.1 (range, 16-51) months who underwent DPN neurectomy at our institution between September 2017 and February 2021. There were 38 women and 10 men, 41 unilateral (22 right, 19 left) and 7 bilateral procedures, with an average age of 67.8 (range, 35-88) years at the time of surgery. A questionnaire that included questions regarding postsurgical dorsal midfoot pain relief, surgical result satisfaction, and current functional limitations was administered via telephone. Demographic information, patient responses, and complications were recorded. Results: Of the 48 patients, 80.8% were satisfied with the result of the surgery in relieving their dorsal midfoot pain, 84.6% would repeat the surgery under the same circumstances, 83.8% would recommend the surgery to a friend, 10.4% reported they wish they had undergone arthrodesis, 91.7% reported pain relief in the first 6 months, and 55.6% reported current activity limitations. Six feet (10.9%) underwent a second procedure with an average postoperative time of 20.5 (range, 1-36) months. Complications included 1 hematoma and deep wound infection, 1 DPN neuroma and superficial peroneal nerve entrapment, and 4 patients with inadequate pain relief. Conclusion: In this cohort, DPN neurectomy appeared to be a reasonable surgical alternative to arthrodesis for the management of chronic dorsal midfoot pain due to midfoot osteoarthritis after failed nonoperative management. Level of Evidence: Level IV, retrospective case series.
Published: 2023
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12. Escitalopram administration, relearning, and neuroplastic effects: A diffusion tensor imaging study in healthy individuals

Author: T, Vanicek, M B, Reed, J, Unterholzner, M, Klöbl, G M, Godbersen, P A, Handschuh, B, Spurny-Dworak, V, Ritter, G, Gryglewski, C, Kraus, D, Winkler, R, Lanzenberger, and R, Seiger
Subjects: Psychiatry and Mental health, Clinical Psychology, Diffusion Magnetic Resonance Imaging, Diffusion Tensor Imaging, Escitalopram, Neuronal Plasticity, Double-Blind Method, Mental Recall, Anisotropy, Brain, Humans, Female, White Matter
Abstract: Neuroplastic processes are influenced by serotonergic agents, which reportedly alter white matter microstructure in humans in conjunction with learning. The goal of this double-blind, placebo-controlled imaging study was to investigate the neuroplastic properties of escitalopram and cognitive training on white matter plasticity during (re)learning as a model for antidepressant treatment and environmental factors.Seventy-one healthy individuals (age=25.6 ± 5.0, 43 females) underwent three diffusion magnetic resonance imaging scans: at baseline, after 3 weeks of associative learning (emotional/non-emotional content), and after relearning shuffled associations for an additional 3 weeks. During the relearning phase, participants received a daily dose of 10 mg escitalopram or placebo orally. Fractional anisotropy (FA), and mean (MD), axial (AD), and radial diffusivity (RD) were calculated within the FMRIB software library and analyzed using tract-based spatial statistics.In a three-way repeated-measures marginal model with sandwich estimator standard errors, we found no significant effects of escitalopram and content on AD, FA, MD, and RD during both learning and relearning periods (pThe intensity of the study interventions might have been too brief to induce detectable white matter changes.Previous studies examining the effects of SSRIs on white matter tracts in humans have yielded inconclusive outcomes. Our results indicate that relearning under escitalopram does not affect the white matter microstructures in healthy individuals when administered for 3 weeks.
Published: 2022
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13. A comparison of criteria for defining metabolic acidemia in live-born neonates and its effect on predicting serious adverse neonatal outcomes

Author: Alexandria C. Kraus, Alexander M. Saucedo, John J. Byrne, Lina F. Chalak, Jessica E. Pruszynski, and Catherine Y. Spong
Subjects: Obstetrics and Gynecology
Published: 2023
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14. Hyperoxia and Acute Kidney Injury: A Tale of Oxygen and the Kidney

Author: Abigayle C. Kraus and Carmen De Miguel
Subjects: Nephrology
Abstract: Although oxygen supplementation is beneficial to support life in the clinic, excessive oxygen therapy also has been linked to damage to organs such as the lung or the eye. However, there is a lack of understanding of whether high oxygen therapy directly affects the kidney, leading to acute kidney injury, and what molecular mechanisms may be involved in this process. In this review, we revise our current understanding of the mechanisms by which hyperoxia leads to organ damage and highlight possible areas of investigation for the scientific community interested in novel mechanisms of kidney disease. Overall, we found a significant need for both animal and clinical studies evaluating the role of hyperoxia in inducing kidney damage. Thus, we urge the research community to further investigate oxygen therapy and its impact on kidney health with the goal of optimizing oxygen therapy guidelines and improving patient care.
Published: 2022

15. 263 INFORMING INTERVENTION DESIGN IN COGNITIVELY IMPAIRED POPULATIONS: LESSONS LEARNED FROM THE OPTIMIZE DEPRESCRIBING INTERVENTION

Author: OC Sheehan, EA Bayliss, AR Green, ML Drace, J Norton, E Reeve, SS Shetterly, S Gleason Kathy, LA Weffald, ML Maciejewski, C Kraus, M Maiyani, J Wolff, and CM Boyd
Subjects: Aging, General Medicine, Geriatrics and Gerontology
Abstract: Background Polypharmacy is common in older adults with cognitive impairment and multiple chronic conditions increasing their risks of adverse drug events, hospitalization, further cognitive decline and death and leading to higher health care costs. Deprescribing, the process of reducing or stopping potentially inappropriate medications may improve outcomes. The OPTIMIZE trial examined whether educating and activating patients, family and clinicians about deprescribing reduces number of medications for older adults with cognitive impairment and multiple chronic conditions. Acceptability and challenges of intervention delivery in this vulnerable population are not well understood. Methods We explored mechanisms of intervention effectiveness through post hoc qualitative interviews and surveys with 15 patients, 7 family caregivers, and 28 clinicians. We assessed accessibility and delivery of materials as well as the ability of the materials to facilitate conversations and influence decisions around deprescribing. Results Acceptance of the intervention was affected by contextual factors including cognition and prior knowledge of deprescribing. Positive effects of the intervention included patients scheduling specific appointments to discuss deprescribing and providers being prompted to consider deprescribing. Recollection of intervention materials by patients was inconsistent but highest shortly after intervention delivery. Short clinic visit times remained the largest clinician barrier to deprescribing. Conclusion Our work identifies key learnings in intervention roll out which can guide future scaling of our intervention and other pragmatic deprescribing intervention studies in patients with cognitive impairment. We highlight the critical roles of both timing and repetition in intervention delivery to cognitively impaired populations as well as the barrier to deprescribing posed by short clinic consultation time. Our success in activating deprescribing conversations in this population highlights the need to incentivize medical professionals and health systems to incorporate deprescribing into routine clinical practice and expand proven interventions to other vulnerable populations.
Published: 2022
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16. Safety and Efficacy of Using Fracture Tables for Prosthetic Hip Dislocations

Author: Marc-Antoine Tremblay, Garrett K. Berger, and Jonathan C. Kraus
Subjects: Hip dislocation, medicine.medical_specialty, medicine.medical_treatment, Hip Dislocations, Prosthetic dislocation, Traction table, 03 medical and health sciences, 0302 clinical medicine, medicine, Orthopedics and Sports Medicine, Prosthetic reduction, 030212 general & internal medicine, Surgical Technique, Fracture table, Reduction (orthopedic surgery), Orthopedic surgery, 030222 orthopedics, business.industry, Emergency department, Traction (orthopedics), Surgery, Total hip replacement surgery, Fracture (geology), Total hip arthroplasty, business, RD701-811
Abstract: The incidence of prosthetic hip dislocation continues to increase because of the overall increase in volume of total hip replacement surgery. Closed reduction is often the preferred treatment, particularly in the first few months after surgery. No matter the closed reduction technique, linear traction is a requirement, thus posing a physically demanding stress opening both surgeon and patient to potential injury. We describe a fracture table closed reduction technique along with outcomes and safety data for a sample of patients. In all 10 reduction procedures, reduction was achieved quickly and without fracture or anesthetic complication. The use of a fracture table for reduction of prosthetic hip dislocation is a viable option, particularly when the surgeon may not have the physical requirements and/or qualified assistance necessary for reduction in the emergency department.
Published: 2021
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17. 315 Coagulopathies and Mortality in Patients With Traumatic Subarachnoid Hemorrhage

Author: E. Melnychuk, A. Berger, and C. Kraus
Subjects: Emergency Medicine
Published: 2022
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18. Improved search for invisible modes of nucleon decay in water with the SNO+ detector

Author: SNO+ Collaboration, A. Allega, M. R. Anderson, S. Andringa, M. Askins, D. J. Auty, A. Bacon, N. Barros, F. Barão, R. Bayes, E. W. Beier, T. S. Bezerra, A. Bialek, S. D. Biller, E. Blucher, E. Caden, E. J. Callaghan, S. Cheng, M. Chen, O. Chkvorets, B. Cleveland, D. Cookman, J. Corning, M. A. Cox, R. Dehghani, C. Deluce, M. M. Depatie, J. Dittmer, K. H. Dixon, F. Di Lodovico, E. Falk, N. Fatemighomi, R. Ford, K. Frankiewicz, A. Gaur, O. I. González-Reina, D. Gooding, C. Grant, J. Grove, A. L. Hallin, D. Hallman, J. Hartnell, W. J. Heintzelman, R. L. Helmer, J. Hu, R. Hunt-Stokes, S. M. A. Hussain, A. S. Inácio, C. J. Jillings, T. Kaptanoglu, P. Khaghani, H. Khan, J. R. Klein, L. L. Kormos, B. Krar, C. Kraus, C. B. Krauss, T. Kroupová, I. Lam, B. J. Land, I. Lawson, L. Lebanowski, J. Lee, C. Lefebvre, J. Lidgard, Y. H. Lin, V. Lozza, M. Luo, A. Maio, S. Manecki, J. Maneira, R. D. Martin, N. McCauley, A. B. McDonald, M. Meyer, C. Mills, I. Morton-Blake, S. Naugle, L. J. Nolan, H. M. O'Keeffe, G. D. Orebi Gann, J. Page, W. Parker, J. Paton, S. J. M. Peeters, L. Pickard, P. Ravi, A. Reichold, S. Riccetto, R. Richardson, M. Rigan, J. Rose, J. Rumleskie, I. Semenec, P. Skensved, M. Smiley, R. Svoboda, B. Tam, J. Tseng, E. Turner, S. Valder, J. G. C. Veinot, C. J. Virtue, E. Vázquez-Jáuregui, J. Wang, M. Ward, J. J. Weigand, J. D. Wilson, J. R. Wilson, A. Wright, J. P. Yanez, S. Yang, M. Yeh, S. Yu, T. Zhang, Y. Zhang, K. Zuber, and A. Zummo
Subjects: High Energy Physics - Experiment (hep-ex), Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, High Energy Physics - Experiment
Abstract: This paper reports results from a search for single and multinucleon disappearance from the O16 nucleus in water within the SNO+ detector using all of the available data. These so-called “invisible” decays do not directly deposit energy within the detector but are instead detected through their subsequent nuclear deexcitation and gamma-ray emission. New limits are given for the partial lifetimes: τ(n→inv)>9.0×1029 years, τ(p→inv)>9.6×1029 years, τ(nn→inv)>1.5×1028 years, τ(np→inv)>6.0×1028 years, and τ(pp→inv)>1.1×1029 years at 90% Bayesian credibility level (with a prior uniform in rate). All but the (nn→inv) results improve on existing limits by a factor of about 3.
Published: 2022
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19. The University of Alabama at Birmingham Surgery Community Network: Tackling the Challenges of Rural Surgery

Author: Abigayle C. Kraus, Drew J. Gunnells, Daniel I. Chu, Alexis E. Kennedy, Tyler G. Hughes, Herb Chen, Robert H. Hollis, John R. Porterfield, Richard D Stahl, and Gregory D. Kennedy
Subjects: General Medicine
Abstract: Over the past 5 years, The University of Alabama at Birmingham (UAB) Department of Surgery has taken a keen interest in the practice of surgery in rural Alabama and has established the UAB surgery community network. Our goal is to improve the delivery of surgical care in rural areas through active recruitment of rural surgeons, the development of research around rural surgery practice, and the expansion of a surgery network throughout the state. Here, we will present the challenges faced by rural surgery, our early work to address these challenges, and offer a plan for moving forward.
Published: 2022

20. A Retrospective Study Characterizing the Radiographic Progression of Hallux Valgus

Author: Vasil V, Kukushliev, Alex T, Burton, Glenn G, Shi, Brian C, Law, and Jonathan C, Kraus
Subjects: General Engineering
Abstract: Hallux valgus deformity is the lateral deviation of the metatarsophalangeal (MTP) joint and is the most common pathology of the great toe, affecting 2%-4% of the population. It is commonly believed that the condition progresses over time both in the magnitude of deformity and development of arthritic changes. To our knowledge, there are rare studies describing the rate of deformity progression and the development of arthritic changes. Our aim is to quantify the progression of hallux valgus and associated arthritic changes in an adult population using radiographs.Patients who are 18 years of age and older (mean age: 61.7 years and range: 18.6-94.2) who presented to our institutions between January 1, 2004, and December 1, 2019, were included. Patients were included in the study if they had hallux valgus on weight-bearing radiographs and two such radiographs at least six months apart. Hallux valgus angle (HVA), intermetatarsal angle (IMA), metatarsophalangeal (MTP) arthritis, tarsometatarsal (TMT) osteoarthritis, Hardy-Clapham sesamoid position, and round sign were collected per patient in the initial and final radiographs. Included cases were first studied together in a whole group. Then, cases were separated into three groups based on the time between initial and final radiographs.A total of 52 radiographic records for 43 patients were included. HVA and IMA progress with time; however, progression does not follow a direct relationship with the time elapsed between initial and final radiographs (p = 0.92 and p = 0.35, respectively). The progression of TMT osteoarthritis, sesamoid position, and round sign do not show a dependence on the time elapsed (p = 0.20, p = 0.11, and p = 0.42, respectively). An increase of one sesamoid unit position over baseline is associated with a 0.85-degree increase in IMA. A one-unit progression of sesamoid position at baseline raises the odds of MTP osteoarthritis progression at the follow-up visit by 2.14 (OR = 2.14, p = 0.0007, CI = [1.35, 3.83]). A HVA increase of one degree increases the odds of TMT osteoarthritis progression at follow-up by a factor of 1.17 (OR = 1.17, p = 0.0005, CI = [1.07, 1.34]). Patients with MTP arthritis at the initial visit have 3.77 times higher odds of round sign progression on their follow-up visit (OR = 3.77, p = 0.027, CI = [1.16, 13.13]).Hallux valgus progression can be quantified. Upon their first visit, a patient's hallux valgus parameters can be utilized to demonstrate expected progression. Progression of the deformity and arthritic changes is slow. Nonetheless, the results should be considered by surgeons and patients when developing a treatment plan with patients.
Published: 2022
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21. Perfectly matched layers in a divergence preserving ADI scheme for electromagnetics.

Author: C. Kraus, Andreas Adelmann, and Peter Arbenz
Published: 2012
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22. New species of Phaeomoniellales from a German vineyard and their potential threat to grapevine (Vitis vinifera) health

Author: M Fischer, C Kraus, U Damm, S Bien, and Ralf T. Voegele
Subjects: Rambutan, Moristroma, Phaeomoniella chlamydospora, Biology, Pathogenicity, Agricultural and Biological Sciences (miscellaneous), Biochemistry, Genetics and Molecular Biology (miscellaneous), Microbiology, Vineyard, Spore, Horticulture, Phylogenetics, Vitis vinifera, Ecology, Evolution, Behavior and Systematics
Abstract: Recently, the order Phaeomoniellales was established that includes fungi closely related to Phaeomoniella chlamydospora, a phytopathogen assumed to be the main causal agent of the two most destructive grapevine trunk diseases, Petri disease and esca. Other species of this order are reported as pathogens of other economically important crops, like olive, peach, apricot, cherry, plum, rambutan, lichee or langsat. However, they are rarely isolated and hence, little is known about their ecological traits and pathogenicity. During a 1-yr period of spore trapping in a German vineyard divided in minimally and intensively pruned grapevines, 23 fungal strains of the Phaeomoniellales were collected. Based on morphological and molecular (ITS, LSU and tub2) analyses the isolated strains were assigned to eight different species. Two species were identified as P. chlamydospora and Neophaeomoniella zymoides, respectively. The remaining six species displayed morphological and molecular differences to known species of the Phaeomoniellales and are newly described, namely Aequabiliella palatina, Minutiella simplex, Moristroma germanicum, Mo. palatinum, Neophaeomoniella constricta and N. ossiformis. A pathogenicity test conducted in the greenhouse revealed that except for P. chlamydospora, none of the species of the Phaeomoniellales isolated from spore traps is able to induce lesions in grapevine wood.
Published: 2020
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23. Cholestasis: A Prospective Study of Perinatal Outcomes and Time to Symptom Improvement

Author: Casey S. Yule, Donald D. McIntire, David B. Nelson, Alexandria C. Kraus, Denisse S. Holcomb, and Charles E. L. Brown
Subjects: Adult, medicine.medical_specialty, Adolescent, Population, Gestational Age, Cholestasis, Intrahepatic, Preeclampsia, Bile Acids and Salts, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Cholestasis, Pregnancy, medicine, Humans, Prospective Studies, education, Prospective cohort study, Survival analysis, education.field_of_study, 030219 obstetrics & reproductive medicine, Obstetrics, business.industry, musculoskeletal, neural, and ocular physiology, Infant, Newborn, Pregnancy Outcome, Obstetrics and Gynecology, Gestational age, Stillbirth, medicine.disease, Texas, Rash, Pregnancy Complications, Logistic Models, Pediatrics, Perinatology and Child Health, Premature Birth, Female, 030211 gastroenterology & hepatology, medicine.symptom, business, Cholestasis of pregnancy
Abstract: Objective Although intrahepatic cholestasis of pregnancy (ICP) remains poorly understood, there are several perinatal complications associated with this condition. This study aimed to examine perinatal outcomes of women with ICP, evaluate outcomes according to severity of disease, and monitor time to symptom improvement following diagnosis. Study Design It involves a prospective, observational study of women with ICP at a single institution. Women with new-onset pruritus without rash were referred to a high-risk obstetrics clinic and evaluated with fasting total bile acids (TBA). Laboratory-confirmed ICP was defined as fasting TBA ≥10 µmol/L. Following diagnosis, a standardized protocol was utilized, including treatment with ursodeoxycholic acid (UDCA). Perinatal outcomes were compared amongst those with and without ICP, and to the general population. Women with ICP were further analyzed based on maximum TBA: 10 to 39, 40 to 99, and ≥100 µmol/L. A Kaplan-Meier survival curve was used to analyze time to symptom improvement. Results A total of 404 patients were evaluated and 212 (52%) were diagnosed with ICP. The mean gestational age at diagnosis was 34.1 ± 3.3 weeks. When comparing those with ICP to those not confirmed, and to the general population, there were no differences in age, parity, mode of delivery, preeclampsia, or stillbirth (p > 0.05). Preterm birth was significantly associated with ICP (p Conclusion Despite treatment with UDCA, women with ICP are at increased risk for spontaneous preterm birth, and this risk significantly increased with severity of disease. Although not significant, a trend exists between increasing time to symptom improvement and worsening severity of disease. Key Points
Published: 2020
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24. Factors used in Applicant Ranking of Orthopedic Foot and Ankle Fellowships and the Availability of Online Information

Author: Madeline A. Perlewitz, Jonathan C. Kraus, Brian C. Law, and Glenn G. Shi
Subjects: Orthopedic surgery, medicine.medical_specialty, business.industry, education, fellowship, Article, Ranking (information retrieval), accessibility, medicine.anatomical_structure, rank, quality, foot, ankle, Physical therapy, Medicine, Ankle, orthopedic, business, Foot (unit), RD701-811
Abstract: Background: The Internet is often the first resource used by applicants to evaluate fellowship programs. However, information on these websites can be often incomplete, inaccessible, and/or inaccurate. The primary objective of this study was to examine key factors that orthopedic foot and ankle fellowship applicants use to rank programs. The secondary objective was to assess both the accessibility and availability of the information on orthopedic foot and ankle fellowship program websites. Methods: A Qualtrics survey was distributed via e-mail to those who matched into an orthopedic foot and ankle fellowship position from years 2008-2020. A comprehensive list of orthopedic foot and ankle fellowship programs was created. Program websites were evaluated for accessibility as well as the quality of recruitment and educational content. Results: There were a total of 114 survey responses out of 644 invites (17.7%). The most important factors for establishing a rank list were operative experience, current faculty, and program reputation. Eighty-five percent (41/48) of orthopedic foot and ankle fellowship websites were directly accessible using Google. On average, accessible orthopedic foot and ankle fellowship websites contained only 57% (11.5/20) of the content deemed desirable. Conclusion: Orthopedic foot and ankle websites are widely accessible and have higher recruitment and educational quality content scores compared with previously published data. The most important factors for establishing a rank list are consistent with previous literature. Those who ranked operative experience as one of the most important factors when establishing a rank list did not complete more operative cases than those who did not. Level of Evidence: Level IV.
Published: 2022

25. Sources and characteristics of dissolved organic carbon in the McKenzie River, Oregon, related to the formation of disinfection by-products in treated drinking water

Author: Kurt D. Carpenter, Tamara E. C. Kraus, Angela M. Hansen, Bryan D. Downing, Jami H. Goldman, Jonathan Haynes, David Donahue, and Karl Morgenstern
Published: 2022
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26. Advancements in Mass Rearing the Air Potato Beetle Lilioceris cheni

Author: Emily C. Kraus, Rosemary Murray, Cassandra Kelm, Ryan Poffenberger, Eric Rohrig, and Kate Fairbanks
Subjects: Dioscorea bulbifera, biological control, invasive species, Chrysomelidae, Insect Science, Science, fungi, food and beverages
Abstract: The air potato beetle, Lilioceris cheni Gressitt and Kimoto (Coleoptera:Chrysomelidae), is a successful biological control agent of the air potato vine, Dioscorea bulbifera L. (Dioscoreales: Dioscoreaceae), in the southern United States. Lilioceris cheni is currently being mass-reared by the Florida Department of Agriculture and Consumer Services Division of Plant Industry (FDACS-DPI) for biological control releases and research. The facility rears and releases over 50,000 adult beetles annually at approximately 1000 different locations. In addition to data on beetle production and distribution, studies on alternative larval and adult diets are described. Adults fed bulbils as the sole food source had reduced life spans compared with beetles given fresh air potato leaves. Adults survived without air potato leaves or bulbils for several days to two weeks depending on availability of leaves at emergence. Larvae did not survive on a modified artificial Colorado potato beetle diet containing fresh air potato vine leaves. Adults survived while consuming artificial diet but ceased oviposition. They, however, resumed egg laying less than one week after being returned to a diet of fresh air potato vine leaves.
Published: 2022

27. Comparison of Omentum and Subcutis as Implant Sites for Device-Encapsulated Human iPSC-Derived Pancreatic Endoderm in Nude Rats

Author: Jolien R. Nijns, Ines De Mesmaeker, Krista G. Suenens, Geert M. Stangé, Kaat De Groot, Maria Marques de Lima, Marine R. C. Kraus, Bart Keymeulen, Wim Waelput, Daniel Jacobs-Tulleneers Thevissen, Daniel G. Pipeleers, Brussels Heritage Lab, Pathology/molecular and cellular medicine, Diabetes Pathology & Therapy, Faculty of Medicine and Pharmacy, Medicine and Pharmacy academic/administration, Basic (bio-) Medical Sciences, Internal Medicine, Diabetes Clinic, Supporting clinical sciences, Experimental Pathology, Pathology, Surgery, and Vriendenkring VUB
Subjects: Transplantation, mice, Endocrinology, Diabetes and Metabolism, Endoderm/metabolism, Biomedical Engineering, Cell Differentiation, Cell Biology, RATS, Rats, Nude, Induced Pluripotent Stem Cells/metabolism, Islets of Langerhans Transplantation/methods, Insulin-Secreting Cells, Humans, Animals, Glucose/metabolism, Omentum
Abstract: Subcutaneous implants of device-encapsulated stem cell–derived pancreatic endoderm (PE) can establish a functional beta cell mass (FBM) with metabolic control in immune-compromised mice. In a study with human-induced pluripotent stem cell-PE, this outcome was favored by a preformed pouch which allowed lesion-free insertion of devices in a pre-vascularized site. This was not reproduced in nude rats, known to exhibit a higher innate reactivity than mice and therefore relevant as preclinical model: a dense fibrotic capsule formed around subcutis (SC) implants with virtually no FBM formation. Placement in omentum (OM) of nude rats provided a less fibrous, better vascularized environment than SC. It resulted in less donor cell loss (56% recovery at post-transplant-PT week 3 versus 16% in SC) allowing FBM-formation. At PT week 30, 6/13 OM-recipients exhibited glucose-induced plasma hu-C-peptide to 0.1–0.4 ng/ml, versus 0/8 in SC-recipients. These levels are more than 10-fold lower than in a state of metabolic control. This shortcoming is not caused by inadequate glucose responsiveness of the beta cells but by their insufficient number. The size of the formed beta cell mass (0.4 ± 0.2 µl) was lower than that reported in mice receiving the same cell product subcutaneously; the difference is attributed to a lower expansion of pancreatic progenitor cells and to their lower degree of differentiation to beta cells. This study in the nude rat model demonstrates that OM provides a better environment for formation of beta cells in device-encapsulated PE-implants than SC. It also identified targets for increasing their dose-efficacy.
Published: 2023
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28. Developing an Ethical Model of Care for People with a Variation of Sex Development in Switzerland

Author: C Kraus and BL Meyrat
Subjects: Public Health, Environmental and Occupational Health
Abstract: Background What constitutes best practice in the area of intersex, renamed Disorders/differences of sex development (DSD/dsd) or even variations of sex development (VDS) after the “Chicago consensus”? What kind of model of care would meet the requirements of an ethical management of intersex/dsd/VDS? Methods In 2005, we launched an interdisciplinary SHS and gender medicine project to improve the standards of care for persons with intersex/dsd/VDS. Abroad, this project, initiated in Lausanne, has sometimes been called the “Swiss Model”. It includes the development of an interdisciplinary team, based at the University hospital CHUV, who takes care of persons born with intersex/dsd/VDS and also teaches an ethical model of care to students at the Medical School of the University of Lausanne. The “Swiss Model” is centered on the children's fundamental rights to bodily integrity, self-determination and genital autonomy. We describe our 10 years' experience, the reasons, goals and development modalities of our team and model of care. Results We have developed a medical ethics “from below” to overcome the lack of ethical recommendations, as it was the case until 2012 in Switzerland. During this period of time, genital surgeries and other non-vital medical treatments have been postponed until the child could fully participate in the medical decisions and give one's informed assent or consent. Only one family did not follow our recommendations. Conclusions The Lausanne experience testifies to the possibility of changing the so-called Johns Hopkins paradigm in actual practice. The model of care we have implemented can define best practice as it is scientifically grounded, medically reasonable, and ethically consistent.
Published: 2021
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29. Durability and Safety of Deep Peroneal Nerve Neurectomy for Midfoot Arthritis at Midterm Follow Up

Author: Jose M. Iturregui, Edward T. Haupt, Benjamin Wilke, Jonathan C. Kraus, and Glenn G. Shi
Subjects: Orthopedics and Sports Medicine
Abstract: Category: Midfoot/Forefoot Introduction/Purpose: Midfoot osteoarthritis affects up to 12% of the adult population greater than 50 years old. Arthrodesis is the traditional surgical procedure performed when nonoperative management fails but is a technically demanding procedure that requires prolonged postoperative immobilization and is not uncommonly complicated by nonunion or deep infection. The deep peroneal nerve (DPN) plays a significant role in afferent nociceptive midfoot joint pain perception, most consistently in the second and third tarsometatarsal joints and the naviculocuneiform joint. Early outcomes following DPN neurectomy have demonstrated promising results as a safe and effective treatment that allows early mobilization and weight bearing. The purpose of our study was to evaluate the mid-term patient satisfaction and pain relief after DPN neurectomy for treatment of chronic midfoot pain due to osteoarthritis. Methods: In this retrospective IRB-approved questionnaire-based study, we evaluated 49 out of 95 patients identified (56 feet) with an average follow-up of 34.6 (range, 9 to 51) months, who underwent DPN neurectomy (Figure 1) at our institution between September 2017 and February 2021. There were 39 women and 10 men, 42 unilateral (23 right, 19 left) and 7 bilateral procedures, with an average age of 67.9 (range, 35 to 88) years at the time of surgery. A questionnaire which included questions regarding post-surgical dorsal midfoot pain relief, surgical result satisfaction, and current functional limitations was administered via telephone. Demographic information, patient responses, and complications were recorded. Results: There was an 81.2% patient satisfaction with the result of the surgery in relieving their dorsal midfoot pain. Of the 49 patients, 84.9% would repeat the surgery under the same circumstances, 84.1% would recommend the surgery to a friend, 10.2% reported they wish they had undergone arthrodesis, 8.2% reported no pain relief in the first 6 months, and 55.8% reported current activity limitations because of dorsal midfoot pain. Six feet (10.7%) underwent a second procedure with an average postoperative time of 20.5 (range, 1 to 36) months. Complications include one patient with deep wound infection, one DPN neurectomy revision and burial into bone, one DPN neuroma excision, one midfoot exostosis excision, and two conversions to arthrodesis. Theoretic complications of neuroarthropathy, midfoot collapse, and development of lesser toe deformities were not observed. Conclusion: DPN neurectomy is a safe and effective surgical option for the management of chronic dorsal midfoot pain due to midfoot osteoarthritis after failed nonoperative management. At midterm follow-up, patients who underwent dorsal midfoot denervation reported acceptable satisfaction rates, similar to those reported for arthrodesis, with associated improved functional outcomes and few complications.
Published: 2022
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30. Advancements in Mass Rearing the Air Potato Beetle

Author: Emily C, Kraus, Rosemary, Murray, Cassandra, Kelm, Ryan, Poffenberger, Eric, Rohrig, and Kate, Fairbanks
Subjects: Dioscorea bulbifera, Chrysomelidae, fungi, food and beverages, biological control, Article, invasive species
Abstract: Simple Summary Mass rearing the air potato beetle, Lilioceris cheni, is a vital contribution to the integrated pest management of the invasive air potato vine. Here, the authors report on the production, distribution, and advancements of a mass rearing method. It was determined that adults are most successful on a diet of fresh air potato leaf. Although to reduce the amount of leaf tissue needed for overwintering populations, they can survive on artificial diet for several months and can be starved for several days to two weeks depending on previous diet. Larvae cannot survive continuously on artificial diet. This information allows those mass rearing beetles to reduce the amount of tissue grown at points in the annual cycle and shows that adult beetles can survive starvation while being distributed or for short periods after release. It also indicates that fresh air potato vine must be available in at least small quantities year-round. This information will assist those attempting to mass rear and distribute the beetle. Abstract The air potato beetle, Lilioceris cheni Gressitt and Kimoto (Coleoptera:Chrysomelidae), is a successful biological control agent of the air potato vine, Dioscorea bulbifera L. (Dioscoreales: Dioscoreaceae), in the southern United States. Lilioceris cheni is currently being mass-reared by the Florida Department of Agriculture and Consumer Services Division of Plant Industry (FDACS-DPI) for biological control releases and research. The facility rears and releases over 50,000 adult beetles annually at approximately 1000 different locations. In addition to data on beetle production and distribution, studies on alternative larval and adult diets are described. Adults fed bulbils as the sole food source had reduced life spans compared with beetles given fresh air potato leaves. Adults survived without air potato leaves or bulbils for several days to two weeks depending on availability of leaves at emergence. Larvae did not survive on a modified artificial Colorado potato beetle diet containing fresh air potato vine leaves. Adults survived while consuming artificial diet but ceased oviposition. They, however, resumed egg laying less than one week after being returned to a diet of fresh air potato vine leaves.
Published: 2021

31. First record of an indigenous South African parasitoid wasp on an imported biological control agent, the water hyacinth hopper

Author: Massimo Olmi, Simon Van Noort, Julie A. Coetzee, and Emily C. Kraus
Subjects: Pontederia, Range (biology), Hyacinth, Insect Science, Botany, Pontederiaceae, Biological pest control, Biology, biology.organism_classification, Agronomy and Crop Science, Indigenous, Parasitoid wasp
Abstract: Water hyacinth, Pontederia crassipes (Martius) [≡Eichhornia crassip es (Martius) Solms-Laubach] (Pontederiaceae), is native to South America, but has expanded its range to many other regions of the...
Published: 2019
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32. An Anatomic and Clinical Study of the Innervation of the Dorsal Midfoot Capsule

Author: Glenn G. Shi, Benjamin K. Wilke, Joseph L. Whalen, Jonathan C. Kraus, and Meredith A. Williams
Subjects: Male, Dorsum, Deep peroneal nerve, business.industry, Peroneal Nerve, Capsule, Anatomy, Middle Aged, Tarsal Joints, DORSAL PAIN, body regions, Clinical study, Osteoarthritis, Cadaver, Peroneal nerves, Humans, Medicine, Female, Orthopedics and Sports Medicine, Surgery, business, Joint Capsule, Aged, Retrospective Studies
Abstract: Background:Dorsal pain from osteoarthritic midfoot joints is thought to be relayed by branches of the medial and lateral plantar, sural, saphenous, and deep peroneal nerves (DPN). However, there is no consensus on the actual number or pathways of the nervous branches for midfoot joint capsular innervation. This study examined the DPN’s terminal branches at the midfoot joint capsules through anatomic dissection and confirmation of their significance in a clinical case series of patients with midfoot pain relief after DPN block.Methods:Eleven cadaveric lower leg specimens, 6 left and 5 right, were dissected using operative loupe magnification. We preserved the terminal branches and recorded their paths and branching patterns. Joint capsular innervations were individually noted. To confirm our hypothesis of significant dorsal midfoot joint capsular innervation by the DPN, we also performed an institutional review board–approved retrospective chart review of 37 patients with painful dorsal midfoot osteoarthritis who underwent diagnostic local anesthetic injection block of the DPN. The percentage of temporary pain relief after the injection was recorded.Results:Terminal innervation of the DPN branches showed distribution of the second and third tarsometatarsal joints in all specimens. Inconsistent innervation of the naviculocuneiform (9/11), fourth (7/11), first (6/11), and fifth (4/11) tarsometatarsal and calcaneocuboid joints (1/11) were observed. The retrospective review of pain relief in patients with dorsal midfoot pain due to arthritis after diagnostic injection demonstrated a mean of 92.1% improvement.Conclusion:Innervation of the dorsal midfoot joint capsule appears to follow a consistent distribution across 3 joints: second and third tarsometatarsal joints and the naviculocuneiform joint. Acute relief of dorsal midfoot arthritic pain after diagnostic injection suggests that dorsal midfoot nociceptive pain is at least partly transmitted by the DPN.Level of Evidence:Level IV, case series.
Published: 2019
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33. Plant‐mediated interactions among above‐ground and below‐ground life stages of a root‐feeding weevil

Author: Emily C. Kraus and Michael J. Stout
Subjects: Above ground, Ecology, biology, Insect Science, Ecology (disciplines), Weevil, Lissorhoptrus oryzophilus, biology.organism_classification, Life stage
Published: 2019
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34. Effects of defoliation on the resistance and tolerance of rice, Oryza sativa, to root injury by the rice water weevil, Lissorhoptrus oryzophilus

Author: Emily C. Kraus and Michael J. Stout
Subjects: Integrated pest management, Oryza sativa, biology, Weevil, Lissorhoptrus oryzophilus, Rice water, biology.organism_classification, medicine.disease_cause, food.food, food, Agronomy, Insect Science, Curculionidae, Infestation, medicine, Poaceae, Ecology, Evolution, Behavior and Systematics
Published: 2019
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35. Multi-segment foot kinematics during gait following ankle arthroplasty

Author: Brian C. Law, Jonathan C. Kraus, Sergey Tarima, Gerald F. Harris, Karl Canseco, Jason T. Long, Katherine A. Konop, Jessica M. Fritz, David M. King, and Karen M. Kruger
Subjects: medicine.medical_specialty, medicine.medical_treatment, 0206 medical engineering, Ankle replacement, Pain, 02 engineering and technology, 03 medical and health sciences, Arthroplasty, Replacement, Ankle, 0302 clinical medicine, Physical medicine and rehabilitation, medicine, Humans, Orthopedics and Sports Medicine, Range of Motion, Articular, Gait, 030203 arthritis & rheumatology, business.industry, Arthritis, 020601 biomedical engineering, Arthroplasty, Sagittal plane, Biomechanical Phenomena, Preferred walking speed, medicine.anatomical_structure, Gait analysis, Ankle, business, Range of motion, Ankle Joint
Abstract: Ankle arthritis is a debilitating disease marked by pain and limited function. Total ankle arthroplasty improves pain while preserving motion and offers an alternative to the traditional treatment of ankle fusion. Gait analysis and functional outcomes tools can provide an objective balanced analysis of ankle replacement for the treatment of ankle arthritis. Twenty-nine patients with end-stage ankle arthritis were evaluated before and after ankle arthroplasty. Multi-segment foot and ankle kinematics were assessed annually following surgery (average 3.5 years, range 1-6 years) using the Milwaukee Foot Model and a Vicon video motion analysis system. Functional outcomes (American Orthopedic Foot and Ankle Society [AOFAS] ankle/hindfoot scale, short form 36 [SF-36] questionnaire) and temporal-spatial parameters were also assessed. Kinematic results were compared to findings from a previously collected group of healthy ambulators. AOFAS and SF-36 mean scores improved postoperatively. Walking speed and stride length increased after surgery. There were significant improvements in tibial sagittal range of motion in terminal stance and hindfoot sagittal range of motion in preswing. Decreased external rotation of the tibia and increased external rotation of the hindfoot were noted throughout the gait cycle. Pain and function improved after ankle replacement as supported by better outcomes scores, increased temporal-spatial parameters, and significant improvement in tibial sagittal range of motion during terminal stance and hindfoot sagittal range of motion during preswing. While multi-segment foot kinematics were improved, they were not restored to control values. Statement of clinical significance: Total ankle arthroplasty does not fully normalize mutli-segment gait kinematics despite improved patient-reported outcomes and gait mechanics.
Published: 2021

36. Low-resistance electrical contact between epitaxially grown thermoelectric oxide material (Ca2CoO3)0.62CoO2 and iridium

Author: Helmut Karl, Alfred Grießer, Thomas c Kraus, and Oliver Klein
Subjects: 010302 applied physics, Materials science, business.industry, Contact resistance, Metals and Alloys, 02 engineering and technology, Surfaces and Interfaces, 021001 nanoscience & nanotechnology, 01 natural sciences, Electrical contacts, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Pulsed laser deposition, Electrical resistance and conductance, Seebeck coefficient, 0103 physical sciences, Thermoelectric effect, Materials Chemistry, Optoelectronics, Thin film, 0210 nano-technology, business, Yttria-stabilized zirconia
Abstract: For the integration of the thermoelectric and magneto resistive active material (Ca2CoO3)0.62CoO2 (Ca3Co4O9) into silicon technology it is mandatory to provide, apart from diffusion barriers and epitaxial growth, electrical contacts with minimal electrical resistance between this oxide and the metal contact. Epitaxial Ca3Co4O9 thin films were grown by pulsed laser deposition on yttria stabilized zirconia (Y2O3)0.09(ZrO2)0.91 (YSZ) and Ir metallized YSZ buffered single crystalline (001)-Si substrates. X-ray diffraction pole figures of these multilayer systems reveal that the Ca3Co4O9 thin film exhibit a 12-fold in-plane rotational symmetry grown on a (001)-Ir and (001)-YSZ surface, but mutually rotated by 15 ∘ . Ir-Ca3Co4O9 thin film electrical contacts were fabricated by lateral structuring and overgrowth to allow 4-wire measurements for determining the pure Ir-Ca3Co4O9 contact current-voltage characteristic and the area specific contact resistance (ASR). We demonstrate, that the Ca3Co4O9/Ir/YSZ and Ca3Co4O9/YSZ layer system allows to realize low ASR, low in-plane electrical resistivity of the Ca3Co4O9 thin film while maintaining a high Seebeck coefficient.
Published: 2021

37. Peak Contact Stress of TMT-1 Joint after Sequential Correction of Hallux Valgus Using a Proximal Opening Wedge Metatarsal Osteotomy (PMO) and Distal Soft Tissue Procedure

Author: Mei Wang, Jonathan C. Kraus, Brian C. Law, Glenn G. Shi, and Michael J. Ziegele
Subjects: Orthodontics, Metatarsal osteotomy, biology, business.industry, Soft tissue, Opening wedge, biology.organism_classification, Article, Valgus, lcsh:RD701-811, Contact mechanics, lcsh:Orthopedic surgery, TMT, Medicine, Joint Pressure, Hallux Valgus, business, Joint (geology)
Abstract: Category: Bunion; Midfoot/Forefoot Introduction/Purpose: The proximal opening wedge metatarsal osteotomy (PMO) of the first metatarsal is a common procedure for the surgical treatment of moderate to severe hallux valgus. Although with a long track record of success, limited work has been dedicated to this procedures effect on the first tarsometatarsal (TMT-1) joint. The purpose of this study is to evaluate the changes in TMT-1 joint contact stress in the diseased and corrected state following an opening wedge osteotomy of the proximal metatarsal. In addition, the effect of a distal soft tissue release (DSTR) was evaluated as it related to both radiographic correction and TMT-1 joint contact stress. Methods: Seven fresh-frozen cadaveric below knee specimens (mean age: 69yrs) with hallux valgus deformities (mean HVA: 31.7+-12.0degs) were obtained for the study. The specimen was loaded up to 400N on an MTS servo hydraulic load frame with the tibia at 90-degree to the neutrally position foot. Joint contact characteristics at TMT-1 joint were measured with a Tekscan pressure sensor (Model6900, 1100psi). A standard proximal metatarsal osteotomy was performed. Various sized metal wedges (3, 5, 7 mm) with locking plates and screws were inserted in the osteotomy for correction. Following initial tests, a complete distal soft tissue release (DSTR) was performed and the specimens were retested. Additionally, dorsoplantar weight bearing (400N) radiograph was obtained for each condition to measure intermetatarsal (IMA) and hallux valgus (HVA) angles. The contact force, area, and peak contact stress were compared among groups using ANOVA and post-hoc multiple comparisons over the untreated (Dunnett test, pResults: The mean HVA decreased with wedge size and DSTR, reached to significant level with 7mm+DSTR (24.1 degs). The mean contact force was 39.7+-32.6 N for untreated specimens. This increased sequentially with opening wedge size and reached statistical significance 7mm opening-wedge (119.6+-53.8 N, p=0.03) and 7mm-wedge+DSTR (116.7+-58.3 N, p=0.04). The peak contact stress followed a similar trend (Figure 1). The mean peak contact stress was 2.3+-1.5 MPa for the untreated specimens and increased incrementally with wedge size to 5.3+-2.6 MPa for 7mm-wedge only (p=0.03) and 5.2+-2.1 MPa for 7mm- wedge+DSTR (p=0.04). Contact area increased with corrections, but none reached significance. Conclusion: The results from this study demonstrate that with sequentially increasing opening wedge size, loading properties through the TMT-1 joint increase. Prior work has demonstrated that joint stresses of over 4.7 MPa can be chondrotoxic, a value which was surpassed with our peak contact stress with the 7mm wedge. This has significant implications for the long-term health of the TMT-1 joint following PMO, potentially predisposing patients to arthritic joint changes. The optimal degree of correction with PMO to limit chondrotoxicity is not known at this time, and is a direction for future work.
Published: 2020

38. Timing of Emergency Postpartum Hospital Visits in the Fourth Trimester

Author: Jamie L. Morgan, Catherine Y. Spong, Alexandria C. Kraus, Shivani Patel, Aldeboran N. Rodriguez, and Devin A. Macias
Subjects: Adult, Abdominal pain, medicine.medical_specialty, Time Factors, Preeclampsia, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Pregnancy, medicine, Humans, Vaginal bleeding, 030212 general & internal medicine, Retrospective Studies, 030219 obstetrics & reproductive medicine, Obstetrics, business.industry, Postpartum Hemorrhage, Postpartum Period, Electronic medical record, Obstetrics and Gynecology, Puerperal Disorders, medicine.disease, Delivery, Obstetric, Texas, Hospitalization, Pediatrics, Perinatology and Child Health, Hypertension, Female, Presentation (obstetrics), medicine.symptom, business, Emergency Service, Hospital, Body mass index, Postpartum period, Delayed Postpartum Hemorrhage
Abstract: OBJECTIVE The concept of the "fourth trimester" emphasizes the importance of individualized postpartum follow-up. Women seek care for urgent issues during this critical time period. Our objective was to evaluate trends in presenting complaints and admissions in an emergency setting over the first 42 days following delivery. STUDY DESIGN Postpartum hospital encounters within 42 days of delivery at our institution from 2015 to 2019 were studied. Demographic information, delivery route, and emergent hospital encounter details were obtained from the electronic medical record. The postpartum encounters were analyzed by week of presentation. Statistical analysis included Student's t-test and Mantel-Haenszel test with p
Published: 2020

39. Search for hep solar neutrinos and the diffuse supernova neutrino background using all three phases of the Sudbury Neutrino Observatory

Author: C. E. Okada, Ilan Levine, David A. Sinclair, D. Chauhan, J. Wendland, J. F. Wilkerson, B. Beltran, F. B. Descamps, Jocelyn Monroe, M. H. Schwendener, N. Gagnon, M. Jerkins, T. Sonley, F. Zhang, N. S. Oblath, G. D. Orebi Gann, H. Deng, B. Aharmim, J. R. Leslie, L. C. Stonehill, R. W. Ollerhead, J. Law, A. L. Hallin, B. T. Cleveland, B. C. Robertson, E. Blucher, Bei Cai, Ryuta Hazama, G. Doucas, K. Boudjemline, N. Tolich, M. Huang, H. Wan Chan Tseung, S. Habib, S. Majerus, Yuen-Dat Chan, K. Graham, T. Kutter, T. J. Winchester, Alain Bellerive, D. L. Wark, M. L. Miller, J. Heise, S. M. Oser, M. Bergevin, L. L. Kormos, R. D. Martin, Andrew Hime, N. McCauley, P. Jagam, S. R. Elliott, G. T. Ewan, C. Kraus, A. Krüger, Keith Rielage, R. G. H. Robertson, S. D. Reitzner, S. N. Ahmed, M. Kos, J. C. Loach, O. Simard, R. Van Berg, P. L. Drouin, K. Gilje, R. L. Hahn, I. Lawson, R. J. Ford, Monica Dunford, C. J. Virtue, E. W. Beier, A. J. Noble, J. Maneira, A. W. P. Poon, J. Caravaca, F. Fleurot, B. L. Wall, A. E. Anthony, Christopher C. M. Kyba, P. J. Doe, G. Prior, N. West, W. J. Heintzelman, Hal Evans, S. J. M. Peeters, C. Howard, J. Farine, H. M. O'Keeffe, K. T. Lesko, S. D. Biller, R. A. Ott, Bernie G. Nickel, P. J. Harvey, Jochen Klein, K. J. Keeter, E. Guillian, H. B. Mak, Minfang Yeh, G. Tešić, N. A. Jelley, S. McGee, J. Tm. Goon, N. Barros, A. B. McDonald, E. D. Hallman, R. MacLellan, T. Tsui, S. R. Seibert, Min Chen, C. B. Krauss, B. A. VanDevender, P. Skensved, D. Waller, B. Jamieson, R. Bonventre, James R. Wilson, B. J. Land, X. Dai, J. A. Secrest, J. A. Detwiler, G. A. Cox, R. Lange, Benjamin Monreal, A. Mastbaum, H. Fergani, R. L. Helmer, Kai Zuber, A. Wright, M. G. Boulay, A. LaTorre, E. J. Callaghan, K. Labe, and Joseph A. Formaggio
Subjects: Physics, Standard solar model, Sudbury Neutrino Observatory, 010308 nuclear & particles physics, Solar neutrino, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astrophysics, 01 natural sciences, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), Supernova, 0103 physical sciences, High Energy Physics::Experiment, Nuclear Experiment (nucl-ex), Neutrino, 010306 general physics, Nuclear Experiment
Abstract: A search has been performed for neutrinos from two sources, the $hep$ reaction in the solar $pp$ fusion chain and the $��_e$ component of the diffuse supernova neutrino background (DSNB), using the full dataset of the Sudbury Neutrino Observatory with a total exposure of 2.47 kton-years after fiducialization. The $hep$ search is performed using both a single-bin counting analysis and a likelihood fit. We find a best-fit flux that is compatible with solar model predictions while remaining consistent with zero flux, and set a one-sided upper limit of $��_{hep} < 30\times10^{3}~\mathrm{cm}^{-2}~\mathrm{s}^{-1}$ [90% credible interval (CI)]. No events are observed in the DSNB search region, and we set an improved upper bound on the $��_e$ component of the DSNB flux of $��^\mathrm{DSNB}_{��_e} < 19~\textrm{cm}^{-2}~\textrm{s}^{-1}$ (90% CI) in the energy range $22.9 < E_��< 36.9$~MeV., 11 pages, 6 figures
Published: 2020

40. New species of

Author: C, Kraus, U, Damm, S, Bien, R T, Voegele, and M, Fischer
Subjects: esca, Phaeomoniella, phylogeny, spore trapping, Article, new taxa, grapevine
Abstract: Recently, the order Phaeomoniellales was established that includes fungi closely related to Phaeomoniella chlamydospora, a phytopathogen assumed to be the main causal agent of the two most destructive grapevine trunk diseases, Petri disease and esca. Other species of this order are reported as pathogens of other economically important crops, like olive, peach, apricot, cherry, plum, rambutan, lichee or langsat. However, they are rarely isolated and hence, little is known about their ecological traits and pathogenicity. During a 1-yr period of spore trapping in a German vineyard divided in minimally and intensively pruned grapevines, 23 fungal strains of the Phaeomoniellales were collected. Based on morphological and molecular (ITS, LSU and tub2) analyses the isolated strains were assigned to eight different species. Two species were identified as P. chlamydospora and Neophaeomoniella zymoides, respectively. The remaining six species displayed morphological and molecular differences to known species of the Phaeomoniellales and are newly described, namely Aequabiliella palatina, Minutiella simplex, Moristroma germanicum, Mo. palatinum, Neophaeomoniella constricta and N. ossiformis. A pathogenicity test conducted in the greenhouse revealed that except for P. chlamydospora, none of the species of the Phaeomoniellales isolated from spore traps is able to induce lesions in grapevine wood.
Published: 2020

41. A Gap in Care? Postpartum Women Presenting to the Emergency Room and Getting Readmitted

Author: Aldeboran N. Rodriguez, Jamie L. Morgan, Catherine Y. Spong, Alexandria C. Kraus, Shivani Patel, and Devin A. Macias
Subjects: Adult, Abdominal pain, medicine.medical_specialty, Time Factors, Patient Readmission, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Pregnancy, medicine, Humans, Vaginal bleeding, 030212 general & internal medicine, Young adult, 030219 obstetrics & reproductive medicine, business.industry, Obstetrics, Postpartum Period, Obstetrics and Gynecology, Puerperal Disorders, medicine.disease, Delivery, Obstetric, Blood pressure, Pediatrics, Perinatology and Child Health, Hypertension, Female, Endometritis, medicine.symptom, business, Emergency Service, Hospital, Body mass index, Postpartum period
Abstract: Objective Emergent postpartum hospital encounters in the first 42 days after birth are estimated to complicate 5 to 12% of births. Approximately 2% of these visits result in admission. Data on emergent visits and admissions are critically needed to address the current maternal morbidity crisis. Our objective is to characterize trends in emergent postpartum hospital encounters and readmissions through chief complaints and admission diagnoses over a 4.5-year period. Study Design All postpartum hospital encounters within 42 days of delivery at our institution from 2015 to 2019 were included. We reviewed demographic information, antepartum, intrapartum, and postpartum care and postpartum hospital encounters. Trends in hospital presentation and admission over the study period were analyzed. Comparisons between women who were admitted to those managed outpatient were performed. Statistical analysis included Chi-square, student's t-test, and Mantel–Haenszel test for trend and ANOVA, as appropriate. A p-value Results Among 8,589 deliveries, 491 (5.7%) presented emergently to the hospital within 42 days of delivery, resulting in 576 hospital encounters. From 2015 to 2019, annual rates of presentation were stable, ranging from 5.0 to 6.4% (p = 0.09). Of the 576 hospital encounters, 224 (38.9%) resulted in an admission with increasing rates from 2.0% in 2015 to 3.4% in 2019 (p = 0.005). Primiparous women with higher body mass index, cesarean delivery, and blood loss ≥1, 000 mL during delivery were significantly more likely to be admitted to the hospital. Women with psychiatric illnesses increasingly utilized the emergency room in the postpartum period (6.7–17.2%, p = 0.03). The most common presenting complaints were fever, abdominal pain, headache, vaginal bleeding, wound concerns, and high blood pressure. Admitting diagnoses were predominantly hypertensive disorder (22.9%), wound complications (12.8%), endometritis (9.6%), headache (6.9%), and delayed postpartum hemorrhage (5.6%). Conclusion The average proportion of women presenting for an emergent hospital encounter in the immediate 42-day postpartum period is 5.7%. Nearly 40% of emergent hospital encounters resulted in admission and the rate increased from to 2.0 to 3.4% over the study period. The most common reasons for presentation were fever, abdominal pain, headache, vaginal bleeding, wound concerns, and hypertension. Hypertension, wound complications, and endometritis accounted for the top three admission diagnoses.
Published: 2020

42. Targeting Mitochondrial Calcium Uptake with the Natural Flavonol Kaempferol, to Promote Metabolism/Secretion Coupling in Pancreatic β-cells

Author: Aurelie Hermant, Marine R.-C. Kraus, Flavien Bermont, Jaime Santo-Domingo, Christian Chabert, Romy Benninga, Umberto De Marchi, Jerome N. Feige, and Guillaume Jacot
Subjects: 0301 basic medicine, insulin, medicine.medical_treatment, Cell Culture Techniques, chemistry.chemical_element, lcsh:TX341-641, Mitochondrion, Pharmacology, Calcium, Article, mitoxantrone, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Insulin-Secreting Cells, Insulin Secretion, medicine, Animals, Humans, Secretion, Mitochondrial calcium uptake, Kaempferols, polyphenols, Nutrition and Dietetics, calcium, kaempferol, Insulin, Metabolism, β-cell, Mitochondria, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Calcium Channels, Signal transduction, Kaempferol, lcsh:Nutrition. Foods and food supply, Food Science
Abstract: Pancreatic &beta, cells secrete insulin to lower blood glucose, following a meal. Maintenance of &beta, cell function is essential to preventing type 2 diabetes. In pancreatic &beta, cells, mitochondrial matrix calcium is an activating signal for insulin secretion. Recently, the molecular identity of the mitochondrial calcium uniporter (MCU), the transporter that mediates mitochondrial calcium uptake, was revealed. Its role in pancreatic &beta, cell signal transduction modulation was clarified, opening new perspectives for intervention. Here, we investigated the effects of a mitochondrial Ca2+-targeted nutritional intervention strategy on metabolism/secretion coupling, in a model of pancreatic insulin-secreting cells (INS-1E). Acute treatment of INS-1E cells with the natural plant flavonoid and MCU activator kaempferol, at a low micromolar range, increased mitochondrial calcium rise during glucose stimulation, without affecting the expression level of the MCU and with no cytotoxicity. Enhanced mitochondrial calcium rises potentiated glucose-induced insulin secretion. Conversely, the MCU inhibitor mitoxantrone inhibited mitochondrial Ca2+ uptake and prevented both glucose-induced insulin secretion and kaempferol-potentiated effects. The kaempferol-dependent potentiation of insulin secretion was finally validated in a model of a standardized pancreatic human islet. We conclude that the plant product kaempferol activates metabolism/secretion coupling in insulin-secreting cells by modulating mitochondrial calcium uptake.
Published: 2020

43. Additional file 3 of The OPTIMIZE patient- and family-centered, primary care-based deprescribing intervention for older adults with dementia or mild cognitive impairment and multiple chronic conditions: study protocol for a pragmatic cluster randomized controlled trial

Author: Bayliss, E. A., S. M. Shetterly, M. L. Drace, J. Norton, A. R. Green, E. Reeve, L. A. Weffald, L. Wright, M. L. Maciejewski, O. C. Sheehan, J. L. Wolff, K. S. Gleason, C. Kraus, M. Maiyani, M. Du Vall, and C. M. Boyd
Subjects: humanities
Abstract: Additional file 3. CONSORT 2012 checklist of information to include when reporting a cluster randomised trial.
Published: 2020
Full Text: View/download PDF

44. Measurement of neutron-proton capture in the SNO+ water phase

Author: K. Frankiewicz, C. Grant, A. LaTorre, M. Nirkko, Joshua R. Klein, G. Prior, C. J. Virtue, P. M. Rost, H. M. O'Keeffe, A. Reichold, D. Chauhan, T. Zhang, Mark Guy Boulay, J. Grove, I. Lam, S. Riccetto, N. McCauley, Y. Zhang, P. Khaghani, I. Semenec, F. Shaker, A. Mastbaum, R. D. Martin, V. Fischer, T. Kaptanoglu, A. S. Inácio, L. L. Kormos, J. Wang, J. Dittmer, Jonathan G. C. Veinot, C. B. Krauss, B. Liggins, L. J. Nolan, M. Rigan, K. Gilje, Robert Svoboda, D. Gooding, R. L. Helmer, B. J. Land, S. C. Walton, Kai Zuber, S. D. Biller, Y. Liu, M. A. Cox, S. Maguire, P. J. Harvey, L. Tian, S. Manecki, Jan J. Weigand, A. Zummo, I. Lawson, A. Maio, A. Wright, A. Bialek, G. D. Orebi Gann, J. Rose, E. J. Leming, E. Falk, E. J. Callaghan, A. Li, M. I. Stringer, B. Krar, L. Lebanowski, R. Van Berg, R. Bayes, B. Hreljac, B. T. Cleveland, J. P. Yanez, P. Woosaree, J. Paton, C. J. Jillings, M. Smiley, F. Barao, L. Pickard, M. L. Chen, P. Mekarski, E. Vázquez-Jáuregui, E. Blucher, F. Di Lodovico, O. Chkvorets, M. Luo, B. Tam, M. J. Parnell, D. J. Auty, E. Turner, T. Kroupova, N. Fatemighomi, V. Lozza, Sofia Andringa, I. Morton-Blake, S. J. M. Peeters, A. L. Hallin, R. Ford, M. Askins, E. W. Beier, A. D. Earle, J. Caravaca, J. Rumleskie, W. J. Heintzelman, E. Caden, J. C.L. Tseng, C. Kraus, J. Hu, E. Marzec, J. Maneira, C. Mills, R. Knapik, R. Bonventre, S. Hans, J. Lidgard, A. S. M. Hussain, Richard Rosero, E. Fletcher, A. B. McDonald, K. Singh, Munish K. Sharma, M. R. Anderson, R. Richardson, J. R. Wilson, T. Pershing, M. M. Depatie, J. Hartnell, N. Barros, Martin Ward, M. Meyer, D. Hallman, Minfang Yeh, D. Horne, P. Skensved, S. Nae, and Y. H. Lin
Subjects: Physics - Instrumentation and Detectors, Proton, Hydrogen, Cherenkov detector, Astrophysics::High Energy Astrophysical Phenomena, Nuclear Theory, Analytical chemistry, chemistry.chemical_element, FOS: Physical sciences, 01 natural sciences, 7. Clean energy, law.invention, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), law, 0103 physical sciences, Neutron detection, Neutron, Nuclear Experiment (nucl-ex), 010306 general physics, Nuclear Experiment, Cherenkov radiation, Physics, 010308 nuclear & particles physics, Detector, Instrumentation and Detectors (physics.ins-det), Neutron capture, chemistry
Abstract: The SNO+ experiment collected data as a low-threshold water Cherenkov detector from September 2017 to July 2019. Measurements of the 2.2-MeV $\gamma$ produced by neutron capture on hydrogen have been made using an Am-Be calibration source, for which a large fraction of emitted neutrons are produced simultaneously with a 4.4-MeV $\gamma$. Analysis of the delayed coincidence between the 4.4-MeV $\gamma$ and the 2.2-MeV capture $\gamma$ revealed a neutron detection efficiency that is centered around 50% and varies at the level of 1% across the inner region of the detector, which to our knowledge is the highest efficiency achieved among pure water Cherenkov detectors. In addition, the neutron capture time constant was measured and converted to a thermal neutron-proton capture cross section of $336.3^{+1.2}_{-1.5}$ mb. info:eu-repo/semantics/publishedVersion
Published: 2020
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45. Additional file 1 of The OPTIMIZE patient- and family-centered, primary care-based deprescribing intervention for older adults with dementia or mild cognitive impairment and multiple chronic conditions: study protocol for a pragmatic cluster randomized controlled trial

Author: Bayliss, E. A., S. M. Shetterly, M. L. Drace, J. Norton, A. R. Green, E. Reeve, L. A. Weffald, L. Wright, M. L. Maciejewski, O. C. Sheehan, J. L. Wolff, K. S. Gleason, C. Kraus, M. Maiyani, M. Du Vall, and C. M. Boyd
Subjects: hemic and lymphatic diseases
Abstract: Additional file 1. List of Potentially Inappropriate Medications (PIMS) used in outcome measurement.
Published: 2020
Full Text: View/download PDF

46. How do stakeholder interactions in Cambodian rice farming villages contribute to a pesticide lock-in?

Author: Rica Joy Flor, Emily C. Kraus, Harro Maat, Buyung A.R. Hadi, Kry Chhay, and Rathmuny Then
Subjects: 0106 biological sciences, Integrated pest management, Returns to scale, Psychological intervention, WASS, Biology, 01 natural sciences, immune system diseases, Adoption, Marketing, Interaction patterns, Government, Stakeholder, food and beverages, Focus group, Social relation, respiratory tract diseases, 010602 entomology, Intervention (law), Information sources, Technologie and Innovatie, Knowledge Technology and Innovation, Kennis, Rice, Kennis, Technologie and Innovatie, Agronomy and Crop Science, 010606 plant biology & botany
Abstract: This paper addresses the conditions and mechanisms that sustain pesticide use by Cambodian rice farmers and constrain a transition to more sustainable pest control practices. We analyzed data from a survey of individual farmers (N = 320), focus group discussions with farmer groups, and interviews with input sellers, rat hunters and local extension agents. Our findings show that farmers mix different types (e.g. herbicides and insecticides) and brands of pesticides in one application. Other chemicals, in particular ‘growth activators’ are often added to these mixes. The interaction patterns and financial arrangements among farmers, pesticide sellers, and laborers promote or sustain these practices. Increasing returns to information and recursive social interaction at the community level thus create a lock-in situation for pesticide use. These findings have direct implications on targeting interventions, which are often aimed at providing knowledge to government extension agents and farmers. Our results suggest that farmers’ knowledge on pest management is not the only driver for their decisions and practices. A broader scope of intervention in communication and feedback loops between stakeholders directly interacting with farmers can help to diversify the suite of recommendations while providing a balance in the information that reaches farmers. Changes in these social arrangements and informal rules may be required to affect positive changes in rice pest management.
Published: 2020
Full Text: View/download PDF

47. Additional file 2 of The OPTIMIZE patient- and family-centered, primary care-based deprescribing intervention for older adults with dementia or mild cognitive impairment and multiple chronic conditions: study protocol for a pragmatic cluster randomized controlled trial

Author: Bayliss, E. A., S. M. Shetterly, M. L. Drace, J. Norton, A. R. Green, E. Reeve, L. A. Weffald, L. Wright, M. L. Maciejewski, O. C. Sheehan, J. L. Wolff, K. S. Gleason, C. Kraus, M. Maiyani, M. Du Vall, and C. M. Boyd
Subjects: mental disorders
Abstract: Additional file 2. ICD 9 and ICD 10 codes used to identify patients with mild cognitive impairment and dementia.
Published: 2020
Full Text: View/download PDF

48. Pupillary response to percutaneous vagal nerve stimulation in alcohol withdrawal syndrome

Author: M. Treiber, G. Josef, B. Vyssoki, J. Szeles, E. Kaniusas, S. Kampusch, H. Walter, O. Lesch, D. König, and C. Kraus
Published: 2022
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49. 392 Outcomes of Patients Presenting to the Emergency Department With Traumatic Subarachnoid Hemorrhage

Author: A.J. Cocciolone, C. Kraus, and E. Melnychuk
Subjects: medicine.medical_specialty, Subarachnoid hemorrhage, business.industry, Emergency medicine, Emergency Medicine, Medicine, Emergency department, business, medicine.disease
Published: 2021
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50. Plexiform Hypoglossal Schwannoma in an 11-Year-Old Child: Diagnosis, Management and Review of the Literature

Author: Scotti F, von, primary, A, Agaimy, additional, B, Popp, additional, S, Endele, additional, C, Kraus, additional, W, Wuest, additional, H, Iro, additional, and M, Koch, additional
Published: 2020
Full Text: View/download PDF

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