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Compiler support required to allow programmers to express their algorithms using a global name-space is discussed. A general method for the analysis of a high-level source program and its translation into a set of independently executing tasks that communicate using messages is presented. It is shown that if the compiler has enough information, the translation can be carried out at compile time; otherwise; run-time code is generated to implement the required data movement. The analysis required in both situations is described, and the performance of the generated code on the Intel iPSC/2 hypercube is presented. >

Any programming environment for distributed memory machines that allows the user to specify pdwallel do loops over globally defined data structures requires optimizations that go beyond the specification of Lrppropriate data and workload partitionings. In this paper, we consider optimizations that are required for efficient execution of a code segment that consists of pmallel loops over distributed data Structures. On distributed memory machines it is typically very expensive tci fetch individual data elements. Instead, before a parallirl loop executes, it is desirable to prefetch all off-processor data required in the loop. We specify a scheme for s boring copies of fetched data along with a scheme for accessing copies of off-processor data during the computafJ ion of the loop. The performance of such optimizations rm the iPSC/2 and the NCUBE is also presented.

Sir, TNFa blocking agents should not be used in patients with high risk of infections whose containment is macrophage/ granuloma dependent, such as mycobacteria, coccidiomycosis or histoplasmosis [1]. In echinococcosis, Th1 cytokines are also important for host defense [2, 3]. It has been shown that TNFa mRNA is located in macrophages in the periparasitic area of the liver [4] leading to the development of an intrahepatic granuloma surrounding the parasite tissue [5]. Otherwise, antibody production in early infection may be stimulated by a T-cell independent mechanism [6]. However, to our best knowledge, cases of the evolution of echinococcosis during TNF inhibitor treatment have not been reported so far. We present a patient with rheumatoid arthritis (RA), who developed echinococcus abscess for

Detection of latent tuberculosis infection is an important step in the control of tuberculosis. The tuberculin skin test is the only proven method for identifying tuberculosis infection in patients who do not have tuberculosis disease. The prevalence of tuberculosis infection among hospitalized patients in a pneumological department of an inner-city hospital was evaluated, using the intradermal tuberculin skin test (Mantoux technique). Interpretation of the Mantoux test was based on the size of induration in millimeters and the individual risk profile of the patients, according to the guidelines of the American Thoracic Society and the Centers for Disease Control, revised in 1989. Of 697 tested patients, 252 showed test results consistent with tuberculosis infection (36.2%). 55 of these 697 patients had active tuberculosis disease or a prior history of tuberculosis (7.9%). A positive tuberculin skin test was found in 197 of 642 patients (30.7%) with a diagnosis different from tuberculosis (COPD, pneumonia, cancer and others). In our study, the sensitivity of the tuberculin skin test for active tuberculosis infection was 95%. The present study revealed a high prevalence of tuberculosis infection among hospitalized patients in a pneumological department. Further studies are needed to assess the usefulness of routine tuberculin skin testing in hospitalized populations.

Programming nonshared memory systems is more difficult than programming shared memory systems, since there is no support for shared data structures. Current programming languages for distributed memory architectures force the user to decompose all data structures into separate pieces, with each piece “owned” by one of the processors in the machine, and with all communication explicitly specified by low-level message-passing primitives. This paper presents a new programming environment for distributed memory architectures, providing a global name space and allowing direct access to remote parts of data values. We describe the analysis and program transformations required to implement this environment, and present the efficiency of the resulting code on the NCUBE/7 and IPSC/2 hypercubes.

In six to nine mongrel dogs the effect of graded doses of intravenous neurotensin (188, 375, 750, and 1500 pmol/kg h) on acid secretion basally or stimulated by distention (by isotonic glucose), peptone (0.5, 1, and 4 g%), and pentagastrin was studied. Neurotensin did not affect acid secretion basally, stimulated by distention, or the maximal peptone dose. However, when submaximal doses (0.5 and 1 g%) of peptone were instilled in the stomach, neurotensin stimulated the secretory response to intragastric peptone. This effect was observed in doses of intravenous neurotensin which mimicked circulating neurotensin concentrations after a standard test meal. Thus, neurotensin could be considered a physiologic stimulant of acid secretion when protein is present in the stomach. The mechanism for this action of neurotensin is unknown but could be partly explained by an enhanced release of gastrin. The potentiating effect of neurotensin on peptone-stimulated acid secretion could play a major role in gastric secretory function of the dog.