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A burdensome, atypical phenotype of Staphylococcus aureus (SA) called S aureus small colony variant (SA-SCV) has been identified, which is induced as a result of a combination of environmental stressors, including polymicrobial interactions. The SA-SCVs exhibit altered phenotypes as a result of metabolic dormancy caused by electron transport deficiency, leading to increased biofilm production and alterations to antimicrobial susceptibility. The SA-SCVs typically exhibit altered colony morphology and biochemical reactions compared with wild-type SA, making them difficult to detect via routine diagnostics. The SA-SCVs have been found to contribute to chronic or recurrent infections, including skin and soft-tissue infections, foreign-body associated infection, cystic fibrosis, and sepsis. There is evidence that SA-SCVs contribute to patient morbidity and mortality as a result of diagnostic difficulties and limited treatment options. New detection methods may need to be developed that can be incorporated into routine diagnostics, which would allow for better assessment of specimens and introduce new considerations for treatment.

Despite the great demand for the characterization of interfacial rheology in academic and industrial research, the study of interfacial rheology is still scarce compared to its counterpart of bulk rheometry and limited only to specialized laboratories. One of biggest hurdles impeding the broad application of interfacial rheometry is the delicate design and the high cost of interfacial rheometers. Here, we propose a new design of a miniature magnetic rod interfacial stress rheometer (mini-ISR), which uses a pair of small permanent magnets as a magnetic trap and a single magnetic coil for perturbation. The simple design of our ISR substantially reduces its dimension, allowing us to directly couple the rheometer to a conventional commercial optical microscope. Such unprecedented adaptability makes the new ISR highly portable and cost-effective. Moreover, the use of a commercial microscope improves the imaging quality and lowers the difficulty of synchronized imaging of interfacial rheometry. We show the calibration of the mini-ISR and demonstrate its functionality by measuring the interfacial rheology and imaging the microscopic dynamics of particle monolayers at a water-oil interface. Our design can be used by any laboratories that have access to optical microscopes for a wide range of interfacial rheology studies.

Spatially heterogeneous Earth radiance scenes affect the atmospheric composition measurements of high-resolution Earth observation spectrometer missions. The scene heterogeneity creates a pseudo-random deformation of the instrument spectral response function (ISRF). The ISRF is the direct link between the forward radiative transfer model, used to retrieve the atmospheric state, and the spectra measured by the instrument. Hence, distortions of the ISRF owing to radiometric inhomogeneity of the imaged Earth scene will degrade the precision of the Level-2 retrievals. Therefore, the spectral requirements of an instrument are often parameterized in the knowledge of the ISRF over non-uniform scenes in terms of shape, centroid position of the spectral channel and the full width at half maximum (FWHM). The Sentinel-5/UVNS instrument is the first push-broom spectrometer that makes use of a concept referred to as a slit homogenizer (SH) for the mitigation of spatially non-uniform scenes. This is done by employing a spectrometer slit formed by two parallel mirrors scrambling the scene in the along track direction (ALT) and hence averaging the scene contrast only in the spectral direction. The flat mirrors do not affect imaging in the across track direction (ACT) and thus preserve the spatial information in that direction. The multiple reflections inside the SH act as coherent virtual light sources and the resulting interference pattern at the SH exit plane can be described by simulations using scalar diffraction theory. By homogenizing the slit illumination, the SH strongly modifies the spectrograph pupil illumination as a function of the input scene. In this work we investigate the impact and strength of the variations of the spectrograph pupil illumination for different scene cases and quantify the impact on the ISRF stability for different types of aberration present in the spectrograph optics.

Shearing a disordered or amorphous solid for many cycles with a constant strain amplitude can anneal it, relaxing a sample to a steady state that encodes a memory of that amplitude. This steady state also features a remarkable stability to amplitude variations that allows one to read the memory. Here, we shed light on both annealing and memory by considering how to mechanically anneal a sample to have as little memory content as possible. In experiments, we show that a “ring-down” protocol reaches a comparable steady state but with no discernible memories and minimal structural anisotropy. We introduce a method to characterize the population of rearrangements within a sample and show how it connects with the response to amplitude variation and the size of annealing steps. These techniques can be generalized to other forms of glassy matter and a wide array of disordered solids, especially those that yield by flowing homogeneously.

The USA300 and USA600 clonal lineages are the cause of many serious Staphylococcus aureus infections. Here, we report the complete genomes of two methicillin-sensitive S. aureus strains isolated from the healthy skin of adults in Colorado, which are most phylogenetically similar to the USA300 and USA600 lineages.

Aim: Fluorescence imaging can visualize polymicrobial populations in chronic and acute wounds based on porphyrin fluorescence. We investigated the fluorescent properties of specific wound pathogens and the fluorescence detected from bacteria in biofilm. Methods: Utilizing Remel Porphyrin Test Agar, 32 bacterial and four yeast species were examined for red fluorescence under 405 nm violet light illumination. Polymicrobial biofilms, supplemented with δ-aminolevulinic acid, were investigated similarly. Results: A total of 28/32 bacteria, 1/4 yeast species and polymicrobial biofilms produced red fluorescence, in agreement with their known porphyrin production abilities. Conclusion: These results identify common wound pathogens capable of producing porphyrin-specific fluorescence and support clinical observations using fluorescence imaging to detect pathogenic bacteria in chronic wounds.

Hypothesis: Particle-laden fluid interfaces are the central component of many natural and engineering systems. Understanding the mechanical properties and improving the stability of such interfaces are of great practical importance. Janus particles, a special class of heterogeneous colloids, might be utilized as an effective surface-active agent to control the assembly and interfacial rheology of particle-laden fluid interfaces. Experiments: Using a custom-built interfacial stress rheometer, we explore the effect of Janus particle additives on the interfacial rheology and microscopic structure of particle-laden fluid interfaces. Findings: We find that the addition of a small amount of platinum-polystyrene (Pt-PS) Janus particles within a monolayer of PS colloids (1:40 number ratio) can lead to more than an order-of-magnitude increase in surface moduli with enhanced elasticity, which greatly improves the stability of the interface. This drastic change in interfacial rheology is associated with the formation of local particle clusters surrounding each Janus particle. We further explain the origin of local particle clusters by considering the interparticle interactions at the interface. Our experiments reveal the effect of local particle structures on the macroscopic rheological behaviors of particle monolayers and demonstrate a new way to tune the microstructure and mechanical properties of particle-laden fluid interfaces.

OBJECTIVE Previous work has examined family income and material hardship in pediatric cancer. However, few studies have focused on perceived financial strain (PFS), or the extent to which caregivers perceive financial stress and worry related to their child's cancer. The current study addresses this gap by a) describing the trajectory of perceived financial strain over the first year of pediatric cancer treatment; b) examining sociodemographic predictors of that trajectory; and c) examining associations between PFS and caregiver and child psychological adjustment. METHOD Primary caregivers of children (Mage = 6.31) recently diagnosed with cancer provided 12 monthly reports of their own perceived financial strain and depression, anxiety, and posttraumatic stress symptoms, as well as their child's internalizing and externalizing symptoms. Data were analyzed using multilevel models. RESULTS Caregiver PFS decreased over the first year of treatment. Nonmarried caregivers and those with lower income reported higher levels of PFS over time. Caregivers with higher PFS relative to other caregivers and relative to their own average PFS in a given month experienced psychological maladjustment. PFS was not associated with child adjustment. CONCLUSIONS On average caregivers perceive less financial strain over the first year of treatment; however, nonmarried caregivers and those with lower income are at risk for higher PFS over time, and PFS may contribute to psychological maladjustment in caregivers. Caregivers may benefit from psychosocial support focused on managing financial strain. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Background: Central nervous system (CNS)-directed treatments can cause long-term academic, social, and emotional difficulties for children with cancer. However, limited research has examined the emergence of problems longitudinally and has often stratified risk by diagnosis alone. Therefore, this study compared competence and adjustment in children, who did and did not receive CNS-directed treatment, over the first 3 years following a cancer diagnosis. Procedure: Mothers, fathers, and children (ages 5–18 years at diagnosis) from 217 families reported on the child's competence (academic, social) and adjustment (anxious/depressed, withdrawn/depressed) near a new cancer diagnosis or relapse and 3 years later. Children were categorized into CNS-directed treatment (n = 112; including cranial radiation, intrathecal chemotherapy, and/or neurosurgery) and non-CNS-directed treatment (n = 105) groups. Results: At enrollment, there were few differences in competence and emotional adjustment among children based on treatment or diagnostic group. At 3 years, mothers and fathers reported poorer social competence for the CNS-directed treatment group, and fathers reported poorer school competence for the CNS-directed treatment group. Over time, father ratings of social competence increased for the non-CNS-directed treatment group, but not the CNS-directed treatment group. While father ratings of academic competence declined for the CNS-directed treatment group, mother ratings declined the most for children diagnosed with a brain tumor. All children demonstrated higher anxious/depressed scores over time. Conclusions: CNS-directed treatment may be a valuable indicator to identify childhood cancer survivors at risk for poor competence during early survivorship. Follow-up screening and supportive services are recommended, as well as additional longitudinal research.

Objective To examine effects of stress on caregiver psychological adjustment during the first year of pediatric cancer. Method Caregivers (N = 159) of children with cancer completed monthly questionnaires assessing domains of caregiver psychological adjustment (depression, anxiety, and posttraumatic stress symptoms) and stress (general life stress, treatment-related stress, caregiver perceptions of treatment intensity and life threat). Effects of stress were assessed at two levels to examine whether within-person changes in stress predicted concurrent changes in caregiver adjustment and whether average stress was associated with between-person differences in caregiver adjustment trajectories. Results Overall, higher levels of stress factors were associated with poorer caregiver adjustment at both the between- and within-person levels, with high average levels of treatment-related stress and general life stress emerging as leading predictors of worse adjustment. Conclusions Both types of stressors, those directly related as well as unrelated to a child's cancer, contribute uniquely to caregiver distress. Caregiver distress is impacted by both overall levels of stress over time as well as month-to-month changes in stress. Implications for informing care for at-risk caregivers are discussed. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

A fundamental challenge for disordered solids is predicting macroscopic yield from the microscopic arrangements of constituent particles. Yield is accompanied by a sudden and large increase in energy dissipation due to the onset of plastic rearrangements. This suggests that one path to understanding bulk rheology is to map particle configurations to their mode of deformation. Here, we perform laboratory experiments and numerical simulations that are designed to do just that: 2D dense colloidal systems are subjected to oscillatory shear, and particle trajectories and bulk rheology are measured. We quantify particle microstructure using excess entropy. Results reveal a direct relation between excess entropy and energy dissipation, that is insensitive to the nature of interactions among particles. We use this relation to build a physically-informed model that connects rheology to microstructure. Our findings suggest a framework for tailoring the rheological response of disordered materials by tuning microstructural properties.

A fundamental challenge for disordered solids is predicting macroscopic yield from the microscopic arrangements of constituent particles. Yield is accompanied by a sudden and large increase in energy dissipation due to the onset of plastic rearrangements. This suggests that one path to understanding bulk rheology is to map particle configurations to their mode of deformation. Here, we perform laboratory experiments and numerical simulations that are designed to do just that: 2D dense colloidal systems are subjected to oscillatory shear, and particle trajectories and bulk rheology are measured. We quantify particle microstructure using excess entropy. Results reveal a direct relation between excess entropy and energy dissipation, that is insensitive to the nature of interactions among particles. We use this relation to build a physically-informed model that connects rheology to microstructure. Our findings suggest a framework for tailoring the rheological response of disordered materials by tuning microstructural properties.

Objective After diagnosis, caregivers of children with cancer, particularly mothers or primary caregivers (PCs), often show elevated depressive symptoms which may negatively impact family functioning. We tested PC and secondary caregiver (SC) depressive symptoms as predictors of family, co-parenting, and marital functioning and whether having a non-depressed SC buffers against potential negative effects of PC depressive symptoms. Methods Families (N = 137) were recruited from two major children's hospitals following a diagnosis of pediatric cancer. Caregivers completed self-report measures of depressive symptoms (Center for Epidemiological Studies-Depression Scale; Depression, Anxiety, and Stress Scale) and marital functioning (Dyadic Adjustment Scale) at 1-month post-diagnosis. A subset of families (n = 75) completed videotaped interaction tasks at approximately 3-months post-diagnosis that were coded for family and co-parenting interactions. Results Higher PC depressive symptoms at 1-month post-diagnosis was associated with higher adaptability and lower conflict in family functioning. PC depressive symptoms were also associated lower dyadic consensus and lower dyadic satisfaction. SC depressive symptoms were not significantly associated with any family/co-parenting/marital functioning variables. Significant interaction analyses suggested that SC depressive symptoms moderated the effect of PC depressive symptoms on family cohesion, withdrawn parenting, and affective expression in the marriage, such that the relationship between PC depressive symptoms and poorer functioning was attenuated when SC depressive symptoms were at low or average levels. Conclusions Having a nondepressed SC buffered against negative effects of PC depressive symptoms on certain domains of family, coparenting, and marital functioning. SCs may play a protective role for families of children with cancer.

Small groups of hysteretic elements can explain how a system returns to a previous state only after multiple driving cycles., When an amorphous solid is deformed cyclically, it may reach a steady state in which the paths of constituent particles trace out closed loops that repeat in each driving cycle. A remarkable variant has been noticed in simulations where the period of particle motions is a multiple of the period of driving, but the reasons for this behavior have remained unclear. Motivated by mesoscopic features of displacement fields in experiments on jammed solids, we propose and analyze a simple model of interacting soft spots—locations where particles rearrange under stress and that resemble two-level systems with hysteresis. We show that multiperiodic behavior can arise among just three or more soft spots that interact with each other, but in all cases it requires frustrated interactions, illuminating this otherwise elusive type of interaction. We suggest directions for seeking this signature of frustration in experiments and for achieving it in designed systems.

The Far-infrared Outgoing Radiation Understanding and Monitoring (FORUM) mission has been selected in September 2019 as the 9th Earth Explorer mission of the European Space Agency. The mission aims to measure the Earth’s Top-Of- Atmosphere (TOA) emission spectrum in the spectral region from 100 to 1600 cm-¹ (i.e. 6.25 to 100 μm). This will fill the current observational gap from space in the far-infrared region (FIR) from 100 to 667 cm-¹ (i.e. from 15 to 100 μm). FORUM measurements will improve the understanding of the climate system by providing, for the first time with high resolution, the spectral features of the far-infrared emission of the Earth with a focus on the contribution to the radiation budget of the continuum absorption of the water vapour rotational bands, on cirrus cloud properties, and on ice/snow surface emissivity. The FORUM mission requires a payload able to spectrally-resolve the Earth's outgoing longwave radiation across the Far-InfraRed (FIR) spectral range with high absolute radiometric accuracy. Characterisation of the surface, atmospheric and cloud/surface heterogeneity in the observed field-of-view is also required to help interpret the measured spectral radiance. These needs dictate the use of two instruments: a spectrometer and an infrared imager. The concepts of both instruments, thoroughly studied in phase A preparatory activities by two independent industrial consortia, are presented in this paper.

When stressed sufficiently, solid materials yield and deform plastically via reorganization of microscopic constituents. Indeed, it is possible to alter the microstructure of materials by judicious application of stress, an empirical process utilized in practice to enhance the mechanical properties of metals. Understanding the interdependence of plastic flow and microscopic structure in these nonequilibrium states, however, remains a major challenge. Here, we experimentally investigate this relationship, between the relaxation dynamics and microscopic structure of disordered colloidal solids during plastic deformation. We apply oscillatory shear to solid colloidal monolayers and study their particle trajectories as a function of shear rate in the plastic regime. Under these circumstances, the strain rate, the relaxation rate associated with plastic flow, and the sample microscopic structure oscillate together, but with different phases. Interestingly, the experiments reveal that the relaxation rate associated with plastic flow at time [Formula: see text] is correlated with the strain rate and sample microscopic structure measured at earlier and later times, respectively. The relaxation rate, in this nonstationary condition, exhibits power-law, shear-thinning behavior and scales exponentially with sample excess entropy. Thus, measurement of sample static structure (excess entropy) provides insight about both strain rate and constituent rearrangement dynamics in the sample at earlier times.

The objective was to characterize the relation between different sources of school-based social support (friends, peers, and teachers) and bereaved siblings' grief and grief-related growth and to examine whether nonparental sources of social support buffer the effects of low parent support on bereaved siblings. Families (N = 85) were recruited from cancer registries at 3 pediatric institutions 3-12 months after a child's death. Bereaved siblings were 8-18 years old (M = 12.39, SD = 2.65) and majority female (58%) and White (74%). During home visits, siblings reported their perceptions of social support from parental and nonparental sources using the Social Support Scale for Children, as well as grief and grief-related growth using the Hogan Sibling Inventory of Bereavement. Parent, friend, and teacher support were positively correlated with grief-related growth, whereas parent and peer support were negatively correlated with grief for adolescents. Teacher and friend support significantly moderated the association between parent support and grief such that teacher and friend support accentuated the positive effects of parent support. Friend and peer support moderated associations between parent support and grief/growth for adolescents but not children. School-based social support, namely from friends, peers, and teachers, appears to facilitate the adjustment of bereaved siblings. Findings suggest that bereaved siblings may benefit from enhanced support from teachers and friends regardless of age, with middle/high school students particularly benefitting from increased support from close friends and peers. (PsycINFO Database Record

Conventional APCs that express MHC class II (MHCII) and co‐stimulatory molecules include dendritic cells (DCs) and macrophages. Beyond these conventional APCs, immune stimulatory cells have been more recently shown to extend to a class of atypical APCs, composed of mast cells, basophils, and eosinophils. Here, we describe a unique type of APC, Gr1−/lowCD11b−/low cells with a granularity and size characteristic of myeloid cells and with the ability to present Ag for crosspresentation. These cells constitutively express MHCII and the costimulatory molecules, CD80, CD86, and CD40. They do not express pan markers of myeloid DCs (CD11c), plasmacytoid DCs (Ly6C), or macrophages (F4/80), and their frequency is inversely correlated with myeloid‐derived suppressor cells (MDSCs) in tumor‐bearing mice. Among splenocytes, they are more abundant than DCs and macrophages, and they exhibit antitumor immune stimulatory function at a steady state without further activation, ex vivo. They are also found within the tumor bed where they retain their immune stimulatory function. Our findings suggest the use of these novel APCs in additional preclinical studies to further investigate their utility in APC‐based cancer immunotherapies., A new class of antigen presenting cells that are able to boost anti‐tumor immune responses is described.

PURPOSE: This study focused on self-perceived mate value of young adult survivors of childhood cancer relative to healthy peers. Qualitative studies indicate potential problems surrounding romantic relationships among survivors, but systematic studies are missing.METHODS: One-hundred forty-nine childhood cancer survivors and 149 matched controls completed online questionnaires about their mate value, social comparison strategies (i.e., upward/downward identifying/contrasting strategies), and marital status. Survivors and controls were aged 20-40 (M = 27.8), 55% were female, and survivors had been treated for brain tumors (n = 52; 35%), leukemia (n = 42; 28%), lymphoma (n = 31; 21%), or other solid tumors (n = 24; 16%) at 5-33 years before study participation.RESULTS: Survivors and controls did not differ on overall mate value, but on individual characteristics: Survivors thought they had a better sense of humor (d = 0.36), were more loyal (d = 0.32), had higher social status (d = 0.26), and were more ambitious (d = 0.19), while also considering themselves less sexually adventurous (d = 0.31), less healthy (d = 0.26), having less desire to have children (d = 0.21), and a less attractive face (d = 0.20). Higher mate value was related to being partnered, more upward-identifying, less upward-contrasting, and less downward-identifying strategies. Moreover, less downward-identifying was associated with higher mate value in survivors, but not controls; whereas greater downward-contrasting was associated with higher mate value among controls only (R(2) = 30.8%).CONCLUSIONS: Survivors do not generally view themselves as less valuable (potential) romantic partners, but they evaluate different characteristics either more positively or more negatively. Social comparison strategies offer targetable points of interventions to intervene on negative self-evaluations, potentially enhancing well-being.

STUDY QUESTION: Do young adult survivors of childhood cancer know their fertility status, in the context of their parenthood goals and screening for gonadal functioning? SUMMARY ANSWER: While 80% of survivors (who were without children) wanted children in the future, most did not know their fertility status, and screening for gonadal functioning was underutilized. WHAT IS KNOWN ALREADY: Survivors of childhood cancer are at risk for infertility, but fertility counseling and assessment are underutilized. Separate studies indicated that survivors’ fertility-related knowledge is poor and that they often wanted to have children. Yet, studies have not investigated the intersection of both issues, as well as potential distress if parenthood goals are not met. STUDY DESIGN, SIZE, DURATION: Young adult male and female survivors of childhood cancer (N = 149) completed cross-sectional surveys, and data for those without children (n = 105, 70.5%) are presented here. PARTICIPANTS/MATERIALS, SETTING, METHODS: Participants were 20–40 years old (M = 26.5), diagnosed 5–33 years prior to study participation, and completed questionnaires online. Knowledge of fertility status, parenthood goals, and potential distress if survivors were unable to have children were assessed. Medical records were reviewed for hormone levels as indicators of screening for gonadal functioning. MAIN RESULTS AND THE ROLE OF CHANCE: Most survivors (n = 81; 77.1%) did not know their fertility status, while over 80% (n = 89) wanted children (neither aspect varied by socio-demographic/cancer-specific factors). Two-thirds of survivors indicated they would be distressed if parenthood goals remained unfulfilled; especially female (versus male, t = 2.64; P = 0.01) or partnered (versus single, t = −3.45; P < 0.001) survivors. Forty survivors (38.1%) had documented assessments of gonadal functioning, of which 33 (82.5%) reported not knowing their fertility status. LIMITATIONS, REASONS FOR CAUTION: Relevant risk factors may have not been identified owing to limited sample size and missing treatment information. The underutilization of screening for gonadal functioning needs further exploration in other pediatric centers. WIDER IMPLICATIONS OF THE FINDINGS: Most adult childhood cancer survivors want to become parents, but do not know their fertility status, which could cause significant psychological distress. Healthcare providers should continuously address fertility among survivors, but more research is needed on how to implement routine fertility counseling and/or testing. STUDY FUNDING/COMPETING INTEREST(S): This study was funded by the Research Institute at Nationwide Children’s Hospital (V.L.) and Dutch Cancer Society (RUG2009-4442, M.A.T.). All authors have no conflict of interest to declare.

Objectives To examine parent-child communication (i.e., openness, problems) and child adjustment among youth with advanced or non-advanced cancer and comparison children. Methods Families (n = 125) were recruited after a child's diagnosis/relapse and stratified by advanced (n = 55) or non-advanced (n = 70) disease. Comparison children (n = 60) were recruited from local schools. Children (ages 10-17) reported on communication (Parent-Adolescent Communication Scale) with both parents, while mothers reported on child adjustment (Child Behavior Checklist) at enrollment (T1) and one year (T2). Results Openness/problems in communication did not differ across groups at T1, but problems with fathers were higher among children with non-advanced cancer versus comparisons at T2. Openness declined for all fathers, while changes in problems varied by group for both parents. T1 communication predicted later adjustment only for children with advanced cancer. Conclusions Communication plays an important role, particularly for children with advanced cancer. Additional research with families affected by life-limiting conditions is needed.

PURPOSE: Childhood cancer is stressful for the entire family. Preoccupation and anxiety surrounding the child's illness may result in parents of children with cancer being overprotective or less emotionally responsive toward their children. Such parenting in response to a negative life event like childhood cancer may cause survivors to be more insecurely attached than healthy peers, which could have downstream effects on survivors' romantic relationships later in life. Therefore, we examined survivors' perspectives on parent behaviors, adult attachment, and marital status among adult survivors of childhood cancer relative to controls.METHODS: One hundred forty-nine young adult survivors and 149 matched controls (Mage = 28, range 20-40) indicated their relationship status (single vs. partnered) and completed standardized questionnaires assessing memories of upbringing (warmth, overprotection, rejection) and adult attachment (avoidance, anxiety).RESULTS: Adult survivors of childhood cancer remembered mothers and fathers as emotionally warmer (d = 0.53/0.30), and mothers as less rejecting than controls (d = 0.30). Adult attachment was overall similar between survivors and controls, but partnered survivors reported particularly low attachment-related anxiety. Childhood cancer was related to higher mother and father warmth, which were associated with lower attachment-related avoidance and in turn with a greater likelihood of being in a relationship.CONCLUSION: Adult childhood cancer survivors did not remember their parents as overprotective, but reported more positive parenting relative to controls; and similar adult attachment and relationship status. The results were unexpected, but offer novel insights for future prospective studies, which are necessary to better understand psychosocial late effects of childhood cancer.

BACKGROUNDRisk factors for impairment in psychosexual development and satisfaction among adult survivors of childhood cancer are poorly understood. The authors compared psychosexual outcomes between survivors and healthy controls, and tested whether at-risk survivors can be identified by 1) treatment neurotoxicity or 2) diagnosis.METHODSA total of 144 young adult survivors of childhood cancer and 144 matched controls completed questionnaires regarding psychosexual development, sexual satisfaction, and satisfaction with relationship status. Survivors were aged 20 to 40 years and were 5 to 34 years after diagnosis. Using medical chart data, survivors were divided into non-neurotoxic (48 survivors), low-dose (36 survivors), and high-dose (58 survivors) neurotoxic treatment groups.RESULTSApart from having fewer lifetime sex partners, survivors did not appear to differ from controls. However, survivors of brain tumors and any survivor who received high-dose neurotoxic treatment reported the lowest rates of achieving milestones of psychosexual development, whereas sexual and relationship status satisfaction were found to be related to relationship status. Neurotoxic treatment intensity further distinguished between survivors of brain tumors with and without psychosexual impairment.CONCLUSIONSThe intensity of neurotoxic treatment may be a valuable indicator of risk for psychosexual impairment relative to diagnosis alone. Health care providers should assess romantic/sexual problems among survivors at risk and make referrals if needed. Cancer 2017;123:1869-1876. (c) 2017 American Cancer Society.The results of the current study indicate that adult survivors of childhood cancer do not differ from healthy controls with regard to their psychosexual development, sexual satisfaction, and relationship status satisfaction. However, more intense neurotoxic treatment appears to be associated with a higher risk of psychosexual impairment, and may be a more meaningful risk indicator than diagnostic category alone.

OBJECTIVES: Bereaved siblings experience more externalizing problems compared to non-bereaved peers and norms; however, the mechanisms explaining this phenomenon have not been empirically examined. This study tested the serial indirect effects of sibling bereavement on adolescents’ externalizing problems through parent distress (i.e., internalizing symptoms) and parenting (i.e., parenting behaviors, parent-adolescent communication). METHODS: During home visits, 72 bereaved adolescents (ages 10–18) whose brother/sister died from cancer and 60 comparison peers reported about their externalizing problems and their mothers’ and fathers’ parenting behaviors (warmth, behavioral control, psychological control) and parent-adolescent communication (open communication, problematic communication). Mothers and fathers reported their own internalizing symptoms. RESULTS: Bereaved siblings reported more externalizing problems (p =.048) and bereaved mothers reported more internalizing symptoms relative to the comparison group (p =.015). Serial multiple mediation models indicated that elevated externalizing problems were partially explained by both bereaved mothers’ internalizing symptoms and parenting and communication (less warmth [CI: 0.04, 0.86], more psychological control [CI: 0.03, 0.66], and more problematic mother-adolescent communication [CI: 0.03, 0.79]), with a significant indirect effect also emerging for open mother-adolescent communication [CI: 0.05, 1.59]. Bereaved fathers did not significantly differ in internalizing symptoms from comparison fathers (p =.453), and no significant indirect effects emerged for fathers. CONCLUSIONS: Elevated externalizing problems in bereaved siblings may result from mothers’ distress and the impact on their parenting and communication. Targeting adjustment and parenting in bereaved mothers following a child’s death may reduce externalizing problems in bereaved siblings. Research to evaluate family-centered interventions is needed.

Context It is challenging to provide supportive intensive care to infants in the neonatal intensive care unit (NICU), giving them every chance for survival, while also trying to minimize suffering for both the infant and parents. Parents who believe their infant is suffering may alter treatment goals based on their perceptions; however, it is unknown how parents come to believe that their infant may be suffering. Objectives To examine bereaved parents' perceptions of infant suffering in the NICU. Methods Parents completed a qualitative interview exploring their perceptions of the level of suffering that their infant experienced at the end of life. Parents whose infant died in a large Midwestern Level IV regional referral NICU from July 2009 to July 2014 were invited to participate. Thirty mothers and 16 fathers from 31 families (31 of 249) participated in telephone interviews between three months and five years after their infant's death. Results Four themes emerged from the qualitative analysis: 1) the presence/absence of suffering, 2) indicators of suffering, 3) temporal components of suffering (trajectory), and 4) influence of perceived suffering on parents, infants, and clinical decision making. Conclusion Parents used signs exhibited by infants, as well as information they received from the health care team to form their perceptions of suffering. Perceived suffering followed different trajectories and influenced the decisions that parents made for their infant. Soliciting parent perspectives may lead to improvements in the understanding of infant well-being, particularly suffering, as well as how parents rely on these perceptions to make treatment decisions for their infant.

We report on an error source and a possible correction which occurs with Fourier Transform Spectrometers due to the use of an integrating detector. The new class of imaging Fourier-Transform-Spectrometers (FTS) is in many cases best realised using continuously moving mirrors and an integrating array detector with fixed frame rate. In case of not perfectly constant optical path difference (OPD) speed, this corresponds to an irregular OPD sampling, resulting in radiometric errors. This effect is well-known and can be solved by resampling, i.e. interpolation on a regular OPD grid. A less known effect is caused by the detector integrating over constant time intervals, which – like the sampling steps - are also of varying length in the OPD domain due to the non-constant OPD speed. The resulting error is discussed in the presented paper, where also an elegant correction method is proposed. Constant-width integration in the OPD domain acts as a spatial low-pass filter on the interferogram. If the integration width varies, a modulation is applied to the interferogram’s envelope. This modulation results in a radiometric error in the spectrum. The presented correction is a finite impulse response filter with only three taps, to be applied to the measured time-sampled interferogram before resampling. In case the interpolation is done with filters, these filters and the new 3-tap filter can be combined to reduce processing overhead.

OBJECTIVE: Pediatric traumatic brain injury (TBI) may affect children's ability to perform everyday tasks (i.e., adaptive functioning). Guided by the American Association for Intellectual and Developmental Disabilities (AAIDD) model, we explored the association between TBI and adaptive functioning at increasing levels of specificity (global, AAIDD domains, and subscales). We also examined the contributions of executive function and processing speed as mediators of TBI's effects on adaptive functioning. METHOD: Children (ages 8-13) with severe TBI (STBI; n = 19), mild-moderate TBI (MTBI; n = 50), or orthopedic injury (OI; n = 60) completed measures of executive function (TEA-Ch) and processing speed (WISC-IV) an average of 2.7 years postinjury (SD = 1.2; range: 1-5.3). Parents rated children's adaptive functioning (ABAS-II, BASC-2, CASP). RESULTS: STBI had lower global adaptive functioning (η2 =.04-.08) than the MTBI and OI groups, which typically did not differ. Deficits in the STBI group were particularly evident in the social domain, with specific deficits in social participation, leisure, and social adjustment (η2 =.06-.09). Jointly, executive function and processing speed were mediators of STBI's effects on global adaptive functioning and in conceptual and social domains. In the STBI group, executive function mediated social functioning, and processing speed mediated social participation. CONCLUSIONS: Children with STBI experience deficits in adaptive functioning, particularly in social adjustment, with less pronounced deficits in conceptual and practical skills. Executive function and processing speed may mediate the effects of STBI on adaptive functioning. Targeting adaptive functioning and associated cognitive deficits for intervention may enhance quality of life for pediatric TBI survivors. (PsycINFO Database Record(c) 2016 APA, all rights reserved). Language: en