23 results on '"C. Goffredo"'
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2. Poster session Wednesday 11 December all day display: 11/12/2013, 09:30-16:00 * Location: Poster area
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S. Bosi, K. Wierzbowska-Drabik, W. Mullens, C. Goh, M. Abdel Ghany, J. Monmeneu, M. Perez Guillen, B. Zaborska, A. Di Lenarda, H. Mueller, M. Dluzniewski, R. Del Pozo Contreras, E. Laraudogoitia Zaldumbide, S. Yurdakul, O. Bech-Hanssen, M. Fernandez Garcia, R. Ippolito, C. Torromeo, B. Popescu, M. Cameli, P. Gaudron, M. Salvetti, R. Amano, E. Osto, P. Cabeza Lainez, G. Generati, C.H. Attenhofer Jost, J. Rueda-Soriano, F. Negri, T. Zielinski, M. El Serafi, Y. Agmon, I. Losano, Y. Qin, I. Castiglione, G. Santambrogio, A. Farhati, P. Menasche, K. Wdowiak-Okrojek, R. Juneja, G. Di Sciascio, N. Gaibazzi, D. Shin, F. Romeo, O. Huttin, P. Puddu, I. Ikonomidis, T. Baran, G. Tinica, A. Bel Minguez, E. Erdogan, M. Herruzo Rojas, I. Ter Horst, J. Suarez De Lezo, P. Bertrand, B. Putnikovic, O. Kretschmar, M. Gigli, F. Scholz, M. Lainscak, O. Rifaie, E. Tahirovic, A. Svanadze, G. Makavos, L. Iliuta, L. G. T. Zacharias, M. Baldelli, A. Porto, C. Di Nora, O. Asghar, A. Ramalli, W. Krol, M. Ahmed Abdel-Rahman, R. Autschbach, R. Tripodi, A. Budaj, V. Velagic, J. Kurcz, J. Aguilar, V. V. Kochmasheva, O. Enescu, H. Triantafyllidi, J. Diago, J. Park, J. Breur, F. Tona, M. Cikes, C. Maurea, T. Edvardsen, B. Igual Munoz, B. Michalski, J. Separovic Hanzevacki, A. Hagege, L. Gullestad, P. Sogaard, T. Fritz-Hansen, M. Rosca, A. Kuch-Wocial, C. Gonzalez Canovas, H. Uyarel, M. Guazzi, E. Pigatto, M. Carminati, R. Soyka, P. Tortoli, D. Djordjevic-Radojkovic, D. De Palma, L. Yuan, E. Mazzotta, M. Henein, D. Botezatu, J. Feng, L. Casteilla, C. Vignati, I. Burazor, M. Krestjyaninov, E. Zhdanova, D. Milicic, H. Mahfoudhi, A. Aziz, P. Trivilou, R. Hoffmann, A. Mysiak, C. Martini, K. Haugaa, F J V M Francisco Jose Valera Martinez, J. Lessick, M. Maccherini, C. Olympios, D. Mutlak, B. Haugen, M. Martin, A. Santoro, A. Orda, B. Skoric, S. Mihaila, M. Jung, G. Leenders, A. Bozkurt, M. Greco, M. Muratori, A. Subinas Elorriaga, Z. Radunovic, A. Osa-Saez, Z. Suciu, M. Alloni, F. Alamanni, J. Choi, J. Schwartz, M. Mericskay, M. Gurzun, D. Leone, P. Omede, J. Sawicki, D. Saura Espin, E. W. Remme, M. Bando, M. Varoudi, J. Gonzalez Carrillo, G. F. Gjerdalen, S. Aakhus, T. Bombardini, F. Veglio, L. Baduena, A. Calin, B. Austin, C. Viacroze, S. Aytekin, C. Santoro, I. Benedek, S. Comenale Pinto, F. Verbrugge, G. Styczynski, M. Sunbul, N. Pandian, T. Forster, J. Hisdal, S. Mondillo, M. Mourali, L. Magda, A. Quesada-Carmona, E. Caiani, G. Pavlidis, S. Ojeda, W. Ding, S. Ramakrishnan, L. Stefanczyk, A. Voumbourakis, A. M. Maceira Gonzalez, B. Igual, C. Selton-Suty, O. B. Kerbikov, B. Karolko, P. Lipiec, F. Meijboom, T. Andersen, M. Pellegrino, M. Lopez-Lereu, J. Kasprzak, Y. Zhao, R. Lang, M. Valdés Chávarri, J. Muir, A. Goetzenich, J. Hooper, M. Driessen, M. Greutmann, S. Casablanca, V. Curci, P. Szymanski, M. Cramer, F. Tosello, C. Gronlund, M. Chiavarelli, A. Cuvelier, P. Mogutova, F. Bandera, G. Greil, P. Fernandez Garcia, E.R. Valsangiacomo Buechel, M. Sobczynska, M. Kennedy, S. Boitard, D. Voilliot, H. Bellsham-Revell, A. Casacalenda, M. Sata, P. J. Sanchez Millan, S. Nishio, C. Chrisochoou, S. Mirfeizi, C. Beladan, K. Steine, M. Lisi, N. Krylova, A. Vlahovic-Stipac, S. Carerj, A. Oxenius, B. Geloneze, R. Calabro, E. Occhetta, P. Caso, R. Massey, B. Cengiz, M. Palencia-Perez, X. Xu, S. Brili, A. Evangelista, D. Mesa, S. Abadi, V. Reskovic Luksic, G. De La Morena Valenzuela, M. Anzini, S. Iliceto, A. Saxena, D. Vinereanu, G. Ussia, M. Sikora-Frac, S. Censi, R. Razavi, T. Wakatsuki, M. Romero, L. Punzi, C. Stefanadis, M. Pepi, E. Chueca Gonzalez, D. Rea, R. Chistol, I. Michalowska, N. Hayes, J. D'hoge, H. Aloui, D. Verhaert, I. Lekuona Goya, O. Sklyanna, K. Taamallah, S. Urheim, B. Natali, G. Sieswerda, M. Casartelli, D. Czarnecka, K. Lagerstrand, T. Chamova, E. Solberg, L. Sabia, M. Vatankulu, M. Obremska, D. Stolfo, H. Haouala, G. Bajraktari, G. Oria Gonzalez, I. Tournev, N. Olsen, O. R. Coelho, F. Spano, J. Yip, M. Anastasiou-Nana, A. Montero Argudo, S. Poli, J.-M. Sellal, P. Kulakowski, K. Kawecka-Jaszcz, O. Sonmez, M. Merlo, A. Chiru, A. Moreo, A. Colombo, R. Dahmani, W. Fehri, V. Rameev, D. Liu, A. Olszanecka, G. Placha, N. Kouris, A. Zaroui, J. Ljubas, G. Famoso, A. Massoni, S. Gao, M. Delgado, I Rodriguez Sanchez, R. Vazquez Garcia, D. Peluso, V. Planat-Benard, J. Cosin-Sales, E. Avenatti, V. Karidas, G. Sinagra, B. Jako, E. Alfonzetti, C. Hernandez Acuna, H. Farouk, D. Foley, M. Chmiela, P. Gripari, G. Patti, J. C. Pareja, Y. Hwang, C. Polte, D. Damaskos, D. Aronson, T. Rechcinski, T. Soeki, D. Simon, D. Anderson, N. Maurea, A. Brunet, C. Florescu, M. Marchei, A. Safarova, F. Cozzi, A. Neskovic, S. Mega, V. Miro-Palau, K. Darahim, B. Bednarz, A. Bitto, F. De Stefano, E. Kostarska-Srokosz, A. Nemes, G. Vizzari, T. Leiner, N. E. Hasselberg, P. Maffei, F. Mezni, Z. Bogdanovic, S. Kul, W. Kosmala, M. Rivero-Ayerza, G. Piscopo, M. Schiariti, V. Cammalleri, V. Kostopoulos, S. Storve, S. Stoerk, I. Planinc, B. Mutlu, J. R. M. Souza, J. J. Onaindia Gandarias, V. Donghi, H. Hamdi, G. Bagadur, A. Mabrouk Salem Omar, M. Floria, A. Klisiewicz, G. Barbati, A. Akhundova, A. Cacicedo, M. Annabi, D. Domingo-Valero, J. Simpson, J. Suarez De Lezo Herreros De Tejada, F. Cesana, D. Sergi, G. Alongi, M. Coppola, L. Grieten, G. Woo, L. Badano, G. Ertl, L. Caballero Jimenez, E. Donal, A. Kalapos, A. Anna Klisiewicz, H. Duengen, F. Mazuelos, U. Aguirre Larracoechea, N. Hasselberg, P. Domsik, L. Fusini, Z. Rezine, M. Misailidou, M. Rodriguez Serrano, D. Waterhouse, K. Keramida, F. Procaccio, G. Dell'era, N. Popova, F. Musumeci, D. Presutti, S F de Marchi, J. Van 'T Sant, S. Moisseyev, K. Paraskevopoulos, L. Molano, J. Estornell Erill, M. Gaspari, Z. Kobalava, I. Jedrzejewska, M. Galderisi, S. Neubauer, Piotr Hoffman, U. Cucchini, O. Miller, W. Kong, A. Swiatowiec, M. Vrolix, C. Grattoni, K. Broch, P. Ibrahimi, M. Garcia Navarro, R. Sheahan, P. Hoffman, M. Boratynska, J. Castillo Ortiz, R. Jankovic-Tomasevic, S. Wijers, P. Lindqvist, C. Tiu, V De Francesco, C. Goffredo, P. Agostoni, H. Yamada, V. Varano, T. Al-Maimoony, P. Wester, P. Schoof, J. Son, P. Piotr Szymanski, F. Righini, O. Agbulut, P. Nardinocchi, A. Aljalloud, I. Stankovic, O. A. Smiseth, L. Halmai, A. Bacaksiz, S. Rayasamudra, D. Filipiak, D. Muraru, D. Zysko, S. Muscoli, O. Goktekin, M. Przewlocka-Kosmala, S. Ryu, Z. Baricevic, M. Meine, J. Monmeneu Menadas, L. Gheorghe, A. Cremonesi, M. Lipczynska, A. Chaim, M. K. Smedsrud, M.D. Espinosa García, S. Mbarki, I. Stamatopoulos, L. Ling, F. Jashari, Y. Juilliere, D. Lahidheb, B. Mcadam, B. Bijnens, B. Pezo Nikolic, V. Guergueltcheva, J.-P. Vallee, O. Erdogan, R. Muscariiello, R. Mincu, M. Deljanin Ilic, C. Coppola, F. Arenga, J. Walker, M. Bono, J. Segura, R. Mechmeche, H. Uppal, S. Hayashi, A. Alhadad, M. Klinger, S. Herrmann, S. Snare, J. Estornell, M. Grecu, L. Lukasz Mazurkiewicz, J. Hotchi, C. Cipresso, E. Esposito, T. Marwick, N. Poteshkina, C. Zito, A. Squeri, V. Razin, I. Paraskevaidis, M. Jemaa, R. Marcun, R. Potluri, A. Anton Ladislao, F. Buendia-Fuentes, M. Pavlovic, S. Salinger-Martinovic, B. Igual-Munoz, T. Seoane, K. Mischke, G. Tamborini, G. Kim, A. Kardos, G. Pizzino, C. Matei, N. Hatam, V. P. Dityatev, H. Torp, A. Degiovanni, F. Rigo, M. Janulewicz, M. Gospodinova, M. Pan, P. Vallerio, F. Gaita, X. Jin, M. Akkaya, B. Pinamonti, A. Javanbakht, B. Lamia, N. A. Yaroshchuk, L. Musial-Bright, W. J. Nadruz, I. Papadakis, G. Kunszt, Y. Hirata, A. Shim, P. Maciejewski, M. Oliva Sandoval, S. Kadivec, E. Pilichowska-Paszkiet, F. Ranocchi, H. Neametalla, K. Hu, I. Sari, F. Carrasco, R. Ancona, R. Weber, R. Ivanova, A. Bartorelli, K. Eskesen, L. Teresi, P. Lopez Lereu, A. Holmgren, M. Kosnik, M. Turfan, M. Sobieszczanska-Malek, E. Kongsgaard, A. Bell, G. Hong, S. Denchev, A. Tasal, D. Mihalcea, F. Weidemann, G. De Caridi, A. Haggui, N. Hajlaoui, P. Alonso-Fernandez, A. Quattrone, M. Massetti, W. Braksator, I. Lekakis, T. Sahin, S. Carasso, F. Dassie, C. Bucca, C. Ginghina, C. A. Szmigielski, J. Baran, Z. Li, E. Aliot, A. Milan, J. Farkas, C. Smeets, D. Stanojevic, H. Dalen, S. Apostolovic, C. Moretti, G. Bruno, X. Zhao, E. Christoforatou, C. Arra, H. Poorzand, J. Ruvira, R. Matasic, F. Maffessanti, T. Vaugrenard, E. Szymczyk, R. Gimaev, S. Tellatin, C. Magnino, S. Velasco Del Castillo, P. Vandervoort, P. Doevendans, A. Dragan, M. Florescu, D. Carballo, P. Marino, D. Lovric, J. Nilson, L. Tong, H. Khorshid, R. Enache, A. Ruck, T. Benedek, R. Winter, M. Ruiz Ortiz, and E. Johansson
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medicine.medical_specialty ,business.industry ,medicine ,Radiology, Nuclear Medicine and imaging ,Medical physics ,General Medicine ,Session (computer science) ,Cardiology and Cardiovascular Medicine ,business - Published
- 2013
3. Club35 Poster Session Thursday 12 December: 12/12/2013, 08:30-18:00 * Location: Poster area
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M. Montoro Lopez, A. Iniesta Manjavacas, R. Mori Junco, L. Pena Conde, I. Pons De Antonio, S. Garcia Blas, T. Lopez Fernandez, R. Moreno Gomez, M. Moreno Yanguela, J. Lopez Sendon, A. Carro, A. Kiotsekoglou, J. Andoh, S. Brown, J. Kaski, Y. Imamura, K. Arai, S. Uematsu, K. Fukushima, H. Hoshi, K. Ashihara, A. Takagi, N. Hagiwara, K. Gillis, G. Bala, B. Roosens, I. Remory, S. Droogmans, G. Van Camp, B. Cosyns, C. Van De Heyning, J. Magne, L. Pierard, P. Bruyere, L. Davin, C. De Maeyer, B. Paelinck, C. Vrints, P. Lancellotti, A. Borowiec, R. Dabrowski, I. Kowalik, B. Firek, T. Chwyczko, J. Janas, H. Szwed, V. Tufaro, G. Fragasso, G. Ingallina, C. Marini, A. Fisicaro, F. Loiacono, A. Margonato, E. Agricola, F. Ferreira, T. Pereira, J. Abreu, J. Labandeiro, A. Fiarresga, A. Ferreira, A. Galrinho, L. Branco, A. Timoteo, R. Ferreira, R. Marmol, M. Gomez, K. Garcia, D. Sanmiguel, C. Cabades, M. Monteagudo, C. Nunez, C. Fernandez, J. Diez, I. Roldan, M. Kolesnyk, M. Ancona, M. Oppizzi, M. Krestjyaninov, V. Razin, R. Gimaev, M. Carminati, C. Piazzese, W. Tsang, R. Lang, E. Caiani, S. Goncalves, A. Ramalho, R. Placido, L. Marta, N. Cortez Dias, A. Magalhaes, M. Menezes, S. Martins, A. Almeida, A. Nunes Diogo, T. M. Stokke, V. Ruddox, S. I. Sarvari, J. E. Otterstad, E. Aune, T. Edvardsen, D. Pirone, V. De Francesco, F. Marino, F. Gervasi, C. Demartini, C. Goffredo, M. Bono, S. Mega, M. Chello, G. Di Sciascio, M. Martin Hidalgo, T. Seoane Garcia, F. Carrasco Avalos, M. Mesa Rubio, M. Delgado Ortega, M. Ruiz Ortiz, F. Mazuelos Bellido, J. Suarez De Lezo Herrero De Tejada, M. Pan Alvarez De Osorio, J. Suarez De Lezo Cruz Conde, A. Lopez Granados, M. Romero Moreno, M. Pan Alvarez-Ossorio, F. Menichetti, M. Bongiorni, B. Ferro, L. Segreti, P. Bertini, R. Mariotti, R. Baldassarri, A. Di Cori, G. Zucchelli, F. Guarracino, A. Santoro, F. Federco Alvino, G. Giovanni Antonelli, R. Raffaella De Vito, R. Roberta Molle, S. Sergio Mondillo, Y. Mahmoud, M. Abdel-Kader, R. Guindy, S. Elzahwy, E. Dijkema, M. Molenschot, M. Slieker, C. Oliveira Da Silva, A. Sahlen, R. Winter, M. Back, A. Ruck, M. Settergren, A. Manouras, K. Shahgaldi, and V. Ruzov
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Medical education ,business.industry ,Thursday ,Medicine ,Radiology, Nuclear Medicine and imaging ,General Medicine ,Session (computer science) ,Cardiology and Cardiovascular Medicine ,business - Published
- 2013
4. 505 Low one-year mortality in chronic heart failure in a hybrid service with a clinic-based follow-up plus hospital readmission: Role of quality of life and distress assessment
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C. Goffredo and G.P. Carboni
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One year mortality ,Service (business) ,Distress ,medicine.medical_specialty ,Hospital readmission ,Quality of life (healthcare) ,business.industry ,Heart failure ,medicine ,Cardiology and Cardiovascular Medicine ,Intensive care medicine ,business ,medicine.disease - Published
- 2003
5. 1206: Low 1-Year Mortality in Chronic Heart Failure: Role of Campus Living with Heart Failure Software for Assessment of Quality of Life in an Hybrid Service with Clinic-Based Follow-up Plus Hospital Readmission
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R. Botti, C. Goffredo, T. Petitti, and G. P. Carboni
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Advanced and Specialized Nursing ,Service (business) ,Medical–Surgical Nursing ,Hospital readmission ,Quality of life (healthcare) ,business.industry ,Heart failure ,medicine ,Medical emergency ,Cardiology and Cardiovascular Medicine ,1 year mortality ,medicine.disease ,business - Published
- 2003
6. [Leg ulcer]
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L, Astignani and C, Goffredo
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Adult ,Diagnosis, Differential ,Male ,Leg Ulcer ,Humans ,Female ,Immunotherapy ,Middle Aged ,Anti-Bacterial Agents - Published
- 1989
7. Newly discovered CO2 vent supports a coral population persisting under high pCO2 environments
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Teixido N, Caroselli E, Alliouane S, Comeau S, Gattuso J-P, Fici P, Micheli F, Mirasole A, Monismith S, Munari M, Palumbi S, Sheets E, Urbini L, de Vittor C, Goffredo S, Gambi MC, and Teixido N, Caroselli E, Alliouane S, Comeau S, Gattuso J-P, Fici P, Micheli F, Mirasole A, Monismith S, Munari M, Palumbi S, Sheets E, Urbini L, de Vittor C, Goffredo S, Gambi MC
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seawater acidification, Ischia, Astroides calycularis, Mediterranean Sea - Published
- 2021
8. Environmental awareness gained during a citizen science project in touristic resorts is maintained after 3 years since participation
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Marta Meschini, Francesca Prati, Ginevra A. Simoncini, Valentina Airi, Erik Caroselli, Fiorella Prada, Chiara Marchini, Mariana Machado Toffolo, Simone Branchini, Viviana Brambilla, Claudia Covi, Stefano Goffredo, Meschini M., Prati F.*, Simoncini G. A., Airi V., Caroselli E., Prada F., Marchini C., Machado Toffolo M., Branchini S., Brambilla V., Covi C., Goffredo S., University of St Andrews. Centre for Biological Diversity, and University of St Andrews. School of Biology
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lcsh:QH1-199.5 ,QH301 Biology ,Informal education ,Environmental education ,Oceanography ,Tourism ,behavioral change ,Citizen science ,sustainable tourism ,lcsh:Science ,Water Science and Technology ,Ecotourism ,Global and Planetary Change ,GE ,informal education ,Cognition ,Public relations ,ecotourism ,economy ,Psychology ,SDG 4 - Quality Education ,GE Environmental Sciences ,Sustainable tourism ,NDAS ,informal environmental education ,Ocean Engineering ,Aquatic Science ,lcsh:General. Including nature conservation, geographical distribution ,volunteer ,pro-environmental behavior in the long-term ,QH301 ,motivation ,Marine Science ,SDG 14 - Life Below Water ,personal satisfaction ,Citizen Science ,business.industry ,pro-environmental behavior ,Economic sector ,SDG 8 - Decent Work and Economic Growth ,NIS ,citizen environmental knowledge and awarene ,cognitive and psychological aspect ,impacts on local ecosystem ,environmental education ,lcsh:Q ,business ,SDG 12 - Responsible Consumption and Production - Abstract
The research leading to these results has received funding from Project AWARE Foundation, ASTOI Association, Milano, Ministry of Tourism of the Arab Republic of Egypt, Settemari S. p. A Tour Operator, Scuba Nitrox Safety International, Viaggio nel Blu Diving Center. Tourism is one of the largest economic sectors in the world. It has a positive effect on the economy of many countries, but it can also lead to negative impacts on local ecosystems. Informal environmental education through Citizen Science (CS) projects can be effective in increasing citizen environmental knowledge and awareness in the short-term. A change of awareness could bring to a behavioral change in the long-term, making tourism more sustainable. However, the long-term effects of participating in CS projects are still unknown. This is the first follow-up study concerning the effects of participating in a CS project on cognitive and psychological aspects at the basis of pro-environmental behavior. An environmental education program was developed, between 2012 and 2013, in a resort in Marsa Alam, Egypt. The study directly evaluated, through paper questionnaires, the short-term (after 1 week or 10 days) retention of knowledge and awareness of volunteers that had participated in the activities proposed by the program. After three years, participants were re-contacted via email to fill in the same questionnaire as in the short-term study, plus a new section with psychological variables. 40.5% of the re-contacted participants completed the follow-up questionnaires with a final sample size of fifty-five people for this study. Notwithstanding the limited sample size, positive trends in volunteer awareness, personal satisfaction regarding the CS project, and motivation to engage in pro-environmental behavior in the long-term were observed. Publisher PDF
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- 2021
9. Diagnostic pitfall in radiological imaging after vacuum-assisted excision of B3 breast lesion: A case report.
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Liberto V, Giuliano FD, Giudice L, Caliandro A, Gigliotti PE, Goffredo C, Volpe M, Cerocchi M, Briganti F, and Pistolese CA
- Abstract
The management of B3 breast lesions using vacuum-assisted excision (VAE) is gaining increasing traction in clinical practice. However, it is infrequently reported in the literature how this technique may affect long-term imaging appearances. We present a challenging case in which the previous VAE site displayed a mass-like appearance that mimicked breast cancer. The purpose of this case report is to share our experience and illustrate the ultrasound and mammographic characteristics of the residual cavity after VAE, in order to contribute to expanding knowledge regarding radiological imaging post-VAE, which is currently still limited., (© 2024 The Authors. Published by Elsevier Inc. on behalf of University of Washington.)
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- 2024
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10. Disorder of sex development: a rare case of a boy with an XY karyotype and Magnetic Resonance Imaging findings of hermaphroditism.
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Meucci R, Bengala M, Manenti G, Montesanto F, Palombi C, Rufi F, Goffredo C, Lombardo E, Serio ML, and Floris R
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Disorders of sexual differentiation are rare congenital conditions in which the chromosomal, anatomic or gonadal sex development is atypical. In some of these patients, chromosomal sex is inconsistent with phenotypic sex; in other cases, the phenotype is not classifiable as either male or female, resulting in a condition known as ambiguous genitalia. These are very complex cases in which diagnostic certainty is not always possible. A multidisciplinary team including geneticists, pediatricians, radiologists is certainly needed to approach these patients. We present the case of an 18-year-old boy with an XY karyotype, ambiguous genitalia, uterus and blind-ending vaginal pouch. The patient had not been previously diagnosed with a disorder of sex development. The patient underwent a panel of genetic analyses and diagnostic imaging investigations. Magnetic resonance imaging was decisive for the identification of the internal genital organs, especially the uterus. At the end of investigations, the patient was diagnosed with 46,XY disorder of sex development. Our purpose is to underline the role of imaging in the diagnosis and management of congenital disorders of sex differentiation.
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- 2023
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11. Impact of Mediterranean diet on metabolic and inflammatory status of patients with polyvascular atherosclerotic disease.
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Piccirillo F, Miano N, Goffredo C, Nusca A, Mangiacapra F, Khazrai YM, De Gara L, Ussia GP, and Grigioni F
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- C-Reactive Protein metabolism, Humans, Incidence, Risk Factors, Diet, Mediterranean
- Abstract
Background and Aims: The Mediterranean Diet (MD) represents a key player in cardiovascular disease prevention. Therefore, we aimed to assess the relationship between adherence to the MD and inflammatory, lipid and glycemic profile in patients affected by polyvascular atherosclerotic disease (PAD). We also investigated the incidence of long-term major adverse cardiovascular events (MACEs) according to MD adherence., Methods and Results: We enrolled 107 patients with PAD, defined as the simultaneous involvement of at least two vascular districts. Adherence to the MD was estimated through a 9-item simplified form of the Mediterranean Diet Score. Improved fasting glycemic and LDL-cholesterol levels were reported in the high-adherence group compared with the low-adherence group (p < 0.001 and p = 0.0049, respectively). Both C-reactive protein and platelet-to-lymphocyte ratio were significantly lower in high-adherence patients than those with poor adherence to the MD (p = 0.0045 and p = 0.008, respectively). During follow-up (mean 34 ± 11 months), fatal events happened exclusively in the low-adherence group (58%), with an event-free survival of 37% compared with 87% in the moderate-adherence group and 70% in the high-adherence group (log-rank p-value < 0.001). Low adherence to the MD was associated with a higher incidence of MACEs in the Cox regression model adjusted for atherosclerotic risk factors (HR 12.23, 95% CI 4.00-37.39)., Conclusions: High adherence to Mediterranean dietary pattern seems to be associated with improving inflammatory and metabolic status in patients suffering from PAD, potentially translating into better long-term cardiovascular outcomes. These findings provide evidence regarding the relevance of MD as a secondary preventive tool in this high-risk population., Competing Interests: Declaration of competing interest All authors declare that they have no conflicts of interest., (Copyright © 2021 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.)
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- 2022
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12. An overview of polyvascular disease.
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Goffredo C, Cavallaro C, and Gervasi F
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- Atherosclerosis complications, Carotid Artery Diseases complications, Coronary Artery Disease complications, Humans, Postoperative Complications prevention & control, Risk Factors, Stroke etiology, Vascular Diseases therapy, Vascular Diseases complications
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- 2020
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13. Percutaneous Left Atrial Appendage Closure: Acute Effects on Left Atrial Pressure in Humans.
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Patti G, Rapacciuolo A, Segreti A, Ussia GP, Goffredo C, and Di Sciascio G
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- Aged, Aged, 80 and over, Atrial Appendage diagnostic imaging, Atrial Fibrillation diagnosis, Atrial Fibrillation physiopathology, Female, Humans, Male, Time Factors, Treatment Outcome, Atrial Appendage physiopathology, Atrial Fibrillation therapy, Atrial Function, Left, Atrial Pressure, Cardiac Catheterization adverse effects, Cardiac Catheterization instrumentation
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- 2019
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14. Intracardiac echocardiography with ultrasound probe placed in the upper left pulmonary vein to guide left atrial appendage closure: First description.
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Patti G, Mantione L, Goffredo C, and Ussia GP
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- Aged, Atrial Fibrillation diagnostic imaging, Atrial Fibrillation physiopathology, Female, Humans, Treatment Outcome, Ultrasonography, Interventional methods, Atrial Fibrillation therapy, Cardiac Catheterization, Echocardiography instrumentation, Pulmonary Veins, Transducers, Ultrasonography, Interventional instrumentation
- Abstract
Intracardiac echocardiography (ICE) has become an effective alternative to trans-esophageal echocardiography (TEE) as a guidance during interventional procedures for structural heart diseases, allowing to proceed under conscious sedation. To guide percutaneous left atrial appendage (LAA) closure, the ICE probe is usually placed in the right atrium, in the pulmonary artery or in the left atrium (LA); however, the views from the right atrium or the pulmonary artery are often suboptimal, debarring a complete visualization of the LAA and the surrounding structures, whereas the LA location requires trans-septal puncture, may provoke LA wall mechanical stimulation and is often associated with unstable position of the ICE probe. In our case, after a second trans-septal puncture, the ICE probe was placed in the upper left pulmonary vein; this was safely performed and provided an optimal imaging of the LAA, comparable to that obtained by TEE, thus warranting an adequate guide during all procedural steps., (© 2018 Wiley Periodicals, Inc.)
- Published
- 2019
- Full Text
- View/download PDF
15. Intradevice misalignment predicts residual leak in patients undergoing left atrial appendage closure.
- Author
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Patti G, Scipione R, Ussia GP, Rapacciuolo A, Goffredo C, and Sedati P
- Subjects
- Aged, Aged, 80 and over, Echocardiography, Doppler, Color, Equipment Design, Equipment Failure, Female, Humans, Male, Middle Aged, Pilot Projects, Tomography, X-Ray, Treatment Outcome, Atrial Appendage surgery, Atrial Fibrillation therapy, Cardiac Catheterization, Endoleak diagnosis, Septal Occluder Device adverse effects
- Abstract
Aims: Postdeployment mutual orientation between the disk and the lobe in patients undergoing left atrial appendage closure with Amplatzer cardiac plug/Amulet device might impact on the risk of residual leak during follow-up. Thus, we evaluated in an exploratory, pilot study whether the degree of intradevice misalignment, measured by cardiac computed tomography (CT), discriminates the occurrence of peridevice leak in those patients., Methods: All patients (N = 15) undergoing percutaneous left atrial appendage closure with those specific devices between April 2013 and January 2015 were prospectively included. All patients received follow-up evaluation by cardiac CT at 6 months after the intervention to calculate the angle of misalignment within the device and to detect presence of residual peridevice leak., Results: The angle of misalignment between the disk and the lobe of the device significantly discriminated between patients with and without peridevice leak (area under the curve 0.96, 95% confidence interval 0.88-1.0; P = 0.003), with an angle more than 20° being associated with nine-fold higher risk of residual leak. This angle of intradevice misalignment calculated by cardiac CT was significantly correlated with that measured by two-dimensional transesophageal echocardiography or X-rays in the cath lab after the device deployment (r = 0.943 and r = 0.938, respectively)., Conclusion: A marked intradevice misalignment after Amplatzer cardiac plug/Amulet device implantation significantly predicts the occurrence of postprocedural leak in patients with atrial fibrillation; if confirmed by larger studies, these findings may impact on practice patterns.
- Published
- 2017
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- View/download PDF
16. Hand-held echocardiography in the setting of pre-operative cardiac evaluation of patients undergoing non-cardiac surgery: results from a randomized pilot study.
- Author
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Cavallari I, Mega S, Goffredo C, Patti G, Chello M, and Di Sciascio G
- Subjects
- Aged, Aged, 80 and over, Equipment Design, Female, Humans, Male, Middle Aged, Pilot Projects, Predictive Value of Tests, Reproducibility of Results, Rome, Time Factors, Echocardiography, Doppler, Color instrumentation, Heart Diseases diagnostic imaging, Point-of-Care Systems, Point-of-Care Testing, Preoperative Care methods, Surgical Procedures, Operative, Transducers
- Abstract
Transthoracic echocardiography is not a routine test in the pre-operative cardiac evaluation of patients undergoing non-cardiac surgery but may be considered in those with known heart failure and valvular heart disease or complaining cardiac symptoms. In this setting, hand-held echocardiography (HHE) could find a potential application as an alternative to standard echocardiography in selected patients; however, its utility in this context has not been investigated. The aim of this pilot study was to evaluate the conclusiveness of HHE compared to standard echocardiography in this subset of patients. 100 patients scheduled for non-cardiac surgery were randomized to receive a standard exam with a Philips Ie33 or a bedside evaluation with a pocket-size imaging device (Opti-Go, Philips Medical System). The primary endpoint was the percentage of satisfactory diagnosis at the end of the examination referred as conclusiveness. Secondary endpoints were the mean duration time and the mean waiting time to perform the exams. No significant difference in terms of conclusiveness between HHE and standard echo was found (86 vs 96%; P = 0.08). Mean duration time of the examinations was 6.1 ± 1.2 min with HHE and 13.1 ± 2.6 min with standard echocardiography (P < 0.001). HHE resulted in a consistent save of waiting time because it was performed the same day of clinical evaluation whereas patients waited 10.1 ± 6.1 days for a standard echocardiography (P < 0.001). This study suggests the potential role of HHE for pre-operative evaluation of selected patients undergoing non-cardiac surgery, since it provided similar information but it was faster and earlier performed compared to standard echocardiography.
- Published
- 2015
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17. Giant left ventricular pseudoaneurysm complicating an acute myocardial infarction in patient with previous cardiac surgery: a case report.
- Author
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Contuzzi R, Gatto L, Patti G, Goffredo C, D'Ambrosio A, Covino E, Chello M, and Di Sciascio G
- Subjects
- Aged, Aneurysm, False diagnosis, Aneurysm, False therapy, Angioplasty, Balloon, Coronary instrumentation, Cardiovascular Agents therapeutic use, Echocardiography, Doppler, Electrocardiography, Fatal Outcome, Heart Aneurysm diagnosis, Heart Aneurysm therapy, Heart Failure diagnosis, Heart Failure therapy, Heart Rupture, Post-Infarction diagnosis, Heart Ventricles pathology, Humans, Male, Myocardial Infarction therapy, Reoperation, Severity of Illness Index, Stents, Aneurysm, False etiology, Cardiac Surgical Procedures, Heart Aneurysm etiology, Heart Failure etiology, Heart Rupture, Post-Infarction etiology, Myocardial Infarction complications
- Abstract
Left ventricular pseudoaneurysm is a nonfrequent complication of acute myocardial infarction. We describe a case of a patient with previous cardiac surgery and recent inferior myocardial infarction, who developed severe congestive heart failure due to a giant pseudoaneurysm of the inferoposterior wall.
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- 2009
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18. [The non-invasive catheterization laboratory].
- Author
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Sciomer S, Galderisi M, Magrí D, Goffredo C, Ansalone G, Dini FL, Di Salvo G, Gallina S, Mele D, Montisci R, Nistri S, Mondillo S, Di Bello V, and Marino PN
- Subjects
- Cardiac Catheterization, Hemodynamics, Humans, Echocardiography, Doppler methods, Heart Function Tests
- Abstract
The objective of this review was to explore the clinical relevance of Doppler echocardiographic techniques in the evaluation of right and left ventricular function. It is well known that echocardiographic and Doppler analysis are able to provide information about several hemodynamic parameters, such as cardiac output, diastolic filling pressure, vascular resistances and pulmonary arterial pressures. This integrated approach, completely reliable and non-invasive, could allow to obtain useful information not only from a diagnostic and prognostic point of view but also for a potential therapeutic management, either pharmacological or surgical. This review summarizes the current knowledge and the emerging applications of echocardiographic and Doppler techniques focusing on the close correlation between Doppler-derived data and those coming from invasive techniques. On the basis of these evidences, the importance, even in daily clinical practice, of a non-invasive catheterization laboratory is clear and able to supply key information about ventricular function and, at the same time, to avoid expensive and unpleasant invasive procedures for patients.
- Published
- 2008
19. Simvastatin reduces platelet-endocardium adhesion in atrial fibrillation.
- Author
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Chello M, Spadaccio C, Patti G, Lusini M, Barbato R, Goffredo C, Di Sciascio G, and Covino E
- Subjects
- Aged, Atrial Fibrillation metabolism, Atrial Function, Right, CD40 Antigens drug effects, CD40 Ligand metabolism, Case-Control Studies, Endocardium physiopathology, Female, Heart Atria physiopathology, Humans, In Vitro Techniques, Male, Middle Aged, Atrial Fibrillation physiopathology, CD40 Antigens metabolism, Endocardium drug effects, Hydroxymethylglutaryl CoA Reductases pharmacology, Platelet Adhesiveness drug effects, Simvastatin pharmacology
- Abstract
Objectives: To evaluate the relationship between CD40/CD40L system and increased thrombogenesis in AF, and to test the effects of simvastatin treatment., Methods: In vitro study using human tissue, University Hospital (tertiary referral center). Experiments on right atrial segments obtained before the onset of cardiopulmonary bypass were done in either presence or absence of 5 microM simvastatin. Two groups of patients in either chronic atrial fibrillation or sinus rhythm at the time of cardiac surgery. The endocardial expression of CD40, the release of CD40L, and adhesion of platelets to endocardium. Additionally, the thickness of platelet aggregates and the platelet distribution on the endocardium were also evaluated., Results: Atrial fibrillation was associated with a significant increase of endocardial CD40 expression (293.1+/-55.1 pg/ml vs. 230.9+/-53.3 pg/ml, p<0.01), and platelet-endocardial adhesion compared with sinus rhythm atria (10.8+/-2.2 vs. 5.2+/-1.3 platelet CD41 AU p<0.01). At immunofluorescence about 62% of fibrillating endocardium was covered by platelets, compared with 12% of not sinus rhythm atria. Addition of simvastatin significantly reduced CD40 expression as well as platelet adhesion to fibrillating atria; its efficacy was not reversed by the addition of mevalonic acid., Conclusions: Chronic atrial fibrillation acutely upregulates CD40 expression as well as platelet adhesion to the endocardium. Simvastatin is effective in modulating this expression, thus it may potentially contribute to reduce the risk of intra-atrial thrombus formation.
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- 2008
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20. Simvastatin increases neutrophil apoptosis and reduces inflammatory reaction after coronary surgery.
- Author
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Chello M, Anselmi A, Spadaccio C, Patti G, Goffredo C, Di Sciascio G, and Covino E
- Subjects
- Aged, Coronary Angiography, Coronary Artery Bypass mortality, Coronary Disease diagnostic imaging, Coronary Disease mortality, Cytokines drug effects, Cytokines metabolism, Dose-Response Relationship, Drug, Double-Blind Method, Drug Administration Schedule, Female, Follow-Up Studies, Humans, Middle Aged, Neutrophil Activation drug effects, Postoperative Complications prevention & control, Preoperative Care, Probability, Reference Values, Risk Assessment, Severity of Illness Index, Survival Rate, Treatment Outcome, Apoptosis drug effects, Coronary Artery Bypass methods, Coronary Disease surgery, Simvastatin administration & dosage, Systemic Inflammatory Response Syndrome prevention & control
- Abstract
Background: Neutrophils play a central role in systemic inflammatory reaction after cardiopulmonary bypass. Apoptosis is significantly delayed, and this might exacerbate systemic and myocardial damage. We tested the hypothesis of whether pretreatment with simvastatin increases the apoptotic rate of neutrophils and hence reduces the entity of inflammatory reaction., Methods: Thirty patients undergoing coronary surgery with cardiopulmonary bypass were randomized to treatment with either simvastatin (40 mg/day) or placebo for 3 weeks before surgery. A group of 15 patients undergoing off-pump coronary surgery served as controls. Blood samples for detection of serum cytokine levels were obtained before anesthesia, at the end of surgery, and at 4, 24, 48, and 72 hours postoperatively. Apoptosis and indices of activation were assessed in cultured neutrophils., Results: Simvastatin significantly reduced the postoperative peak values of interleukin (IL)-6 and IL-8. The neutrophil apoptotic rate was significantly higher among neutrophils obtained from patients pretreated with simvastatin (p < 0.05 at both 8 and 24 hours) compared with placebo. Neutrophils from the statin group had depressed functional activity, as underscored by significantly lower values of CD11b (p < 0.01 at 24 hours) and a significantly less percentage of cells positive for nitro-blue tetrazolium (p < 0.01 at 12 and 24 hours) compared with placebo., Conclusions: This randomized, double-blind study indicates that statin therapy before cardiopulmonary bypass is associated with reduction of circulating markers of inflammation and increased neutrophil apoptosis. These data support a routine inclusion of statins as an adjuvant pharmacologic therapy before cardiopulmonary bypass surgery.
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- 2007
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21. Effects of atorvastatin on arterial endothelial function in coronary bypass surgery.
- Author
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Chello M, Goffredo C, Patti G, Candura D, Melfi R, Mastrobuoni S, Di Sciascio G, and Covino E
- Subjects
- Adult, Aged, Analysis of Variance, Atorvastatin, Brachial Artery drug effects, Brachial Artery physiopathology, Cholesterol blood, Double-Blind Method, Endothelium, Vascular physiopathology, Female, Hemodynamics drug effects, Humans, Hyperemia physiopathology, Male, Middle Aged, Nitroglycerin, Postoperative Period, Statistics, Nonparametric, Vasodilation drug effects, Vasodilator Agents, Coronary Artery Bypass, Endothelium, Vascular drug effects, Heptanoic Acids pharmacology, Hydroxymethylglutaryl-CoA Reductase Inhibitors pharmacology, Pyrroles pharmacology
- Abstract
Objective: Endothelial dysfunction represents a critical early component of organ injury following cardiopulmonary bypass. Recent studies demonstrate that the treatment with atorvastatin is associated with a significant improvement of endothelial function independently of its efficacy on cholesterol levels. Therefore, we investigated the effects of preoperative atorvastatin treatment on endothelium function after coronary surgery., Methods: Forty patients undergoing coronary surgery were randomized to treatment with atorvastatin (20 mg/die; N=20) or placebo (N=20) 3 weeks before surgery. Twenty normal patients served as control group. The flow-mediated dilations (FMD) of the brachial artery after both reactive hyperemia (endothelium dependent) and nitroglycerin administration (endothelium independent) were evaluated at baseline, at 48 h, and 5 days postoperatively., Results: At baseline, the endothelium-dependent FMD was significantly attenuated in coronary versus normal patients (normal 10.3+/-1.8% vs coronary 4.1+/-1.6%, p<0.01). At 48 h postoperatively all patients exhibited a reduced FMD compared with baseline values: the endothelium-dependent dilatation showed a drop of 60.1+15% in the patients of the placebo group compared with 45.8+16.6% (p<0.05) those in the atorvastatin group. At the univariate analysis, no significant correlation was found between serum levels of either total cholesterol or HDL cholesterol and FMD. The nitroglycerin-induced dilation was not significantly influenced by extracorporeal circulation as well as by atorvastatin treatment., Conclusions: The endothelial dysfunction following cardiopulmonary bypass is improved by the treatment with atorvastatin, by a mechanism unrelated to the drug efficacy of controlling serum cholesterol levels.
- Published
- 2005
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22. Impaired flow-mediated dilation and risk of restenosis in patients undergoing coronary stent implantation.
- Author
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Patti G, Pasceri V, Melfi R, Goffredo C, Chello M, D'Ambrosio A, Montesanti R, and Di Sciascio G
- Subjects
- Aged, Angiotensin-Converting Enzyme Inhibitors therapeutic use, Brachial Artery diagnostic imaging, Brachial Artery physiopathology, Cohort Studies, Coronary Restenosis etiology, Coronary Restenosis physiopathology, Coronary Stenosis physiopathology, Diabetes Complications, Disease-Free Survival, Endothelium, Vascular metabolism, Endothelium, Vascular physiopathology, Female, Follow-Up Studies, Humans, Life Tables, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Risk, Ultrasonography, Angioplasty, Balloon, Coronary, Coronary Restenosis epidemiology, Coronary Stenosis therapy, Hemorheology, Stents, Vasodilation
- Abstract
Background: Impaired endothelial function is a key event in the atherosclerosis process and predicts future cardiovascular events in subjects with and without coronary artery disease (CAD). We performed the first prospective study evaluating whether early measurement of brachial artery endothelium-dependent dilation (flow-mediated dilation [FMD]) after coronary stenting could predict occurrence of in-stent-restenosis., Methods and Results: The study population included 136 patients with single-vessel CAD undergoing percutaneous coronary intervention (PCI) with stenting and at least 6 months of follow-up. All patients underwent ultrasound detection of brachial artery reactivity 30 days after PCI; FMD was investigated before and after 5 minutes of occlusion of the brachial artery, and nitroglycerin-mediated dilation was investigated before and after administration of sublingual nitrates. Clinical in-stent restenosis was demonstrated in 20 patients (15%), whereas 116 patients (85%) remained free of signs or symptoms of recurrent ischemia. FMD was significantly impaired in patients with restenosis versus those without restenosis (percent diameter variation 4.6+/-5.8% versus 9.5+/-6.6%, P=0.002); moreover, 4% of patients with FMD > or =7% (median value) developed in-stent restenosis versus 28% of those with FMD <7% (P=0.0001). On multivariate analysis, FMD was the strongest predictor of restenosis (OR 4.5, 95% CI 2.4 to 12.0); conversely, nitroglycerin-mediated dilation did not independently predict the risk of restenosis (OR 2.4, 95% CI 0.8 to 6.3)., Conclusions: This is the first prospective study indicating that impaired FMD independently predicts occurrence of in-stent restenosis in patients undergoing PCI. Early evaluation of endothelial function after stenting may represent a useful screening tool to stratify patients according to future risk of restenosis.
- Published
- 2005
- Full Text
- View/download PDF
23. [Leg ulcer].
- Author
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Astignani L and Goffredo C
- Subjects
- Adult, Anti-Bacterial Agents therapeutic use, Diagnosis, Differential, Female, Humans, Immunotherapy, Male, Middle Aged, Leg Ulcer diagnosis, Leg Ulcer therapy
- Published
- 1989
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