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The SIDDHARTA-2 experiment installed at the DA$\mathrm{\Phi}$NE collider of INFN-LNF performed, for the first time, measurements of high-n transitions in intermediate mass kaonic atoms during the data taking campaigns of 2021 and 2022. Kaonic carbon, oxygen, nitrogen and aluminium transitions, which occur in the setup materials, were measured by using the kaons stopped in the gaseous helium target cell with aluminium frames and Kapton walls, and are reported in this paper. These new kaonic atoms measurements add valuable input to the kaonic atoms transitions data base, which is used as a reference for theories and models of the low-energy strong interaction between antikaon and nuclei. Moreover, these results pave the way for future dedicated kaonic atoms measurements through the whole periodic table and to a new era for the antikaon-nuclei studies at low energy., Comment: 8 pages, 7 figures

Rhipicephalus (Boophilus) microplus is an ectoparasite of economic importance to cattle-rearing in tropical and subtropical countries, especially Brazil. This study aimed to assess the biological control activity of the fungus Metarhizium anisopliae in pastures at experimental farms belonging to the Unidade Regional de Pesquisa e Desenvolvimento de Pindamonhangaba (PRP) and Americana (IZ). Two areas were established in each location (treatment area vs. control area), and each contained seven animals. The treatment areas were sprayed with suspensions of the fungus M. anisopliae (IBCB 425) at a concentration of 5 x 1013 conidia per hectare (ha) in association with mineral oil. The control areas were sprayed only with water and mineral oil. Every two weeks, the levels of tick infestation on the animals were assessed in both the treated and the control area. The results from counting teleogynes on the cattle showed that the treatment with M. anisopliae was efficient, such that infestation remained greater in the control group in both locations evaluated. The annual mean efficacy was 36% for PRP and 48% for IZ. The application of the fungus M. anisopliae (IBCB 425) to pastures reduced the infestation of R. microplus and may constitute an effective strategy to combat this ectoparasite. Further studies will enable the refinement of this treatment.

Background: This mini-review aims to summarize and discuss previous and recent advances in the clinical presentation, pathophysiology, diagnosis, treatment, and outcome of SARS-CoV-2-associated peripheral neuropathies. Methods: Literature review. Results: Altogether, 105 articles about SARS-CoV-2-associated neuropathy describing 261 patients were retrieved. Peripheral neuropathy in patients with COVID-19 is frequent and predominantly due to immune mechanisms or neurotoxic side effects of drugs used to treat the symptoms of COVID-19 and, to a lesser extent, due to the compression of peripheral nerves resulting from prolonged bedding in the Intensive Care Unit (ICU) and pre-existing risk factors such as diabetes. SARS-CoV-2 does not cause viral neuropathy. Neurotoxic drugs such as daptomycin, linezolid, lopinavir, ritonavir, hydro-chloroquine, cisatracurium, clindamycin, and glucocorticoids should be administered with caution and patients should be appropriately bedded in the ICU to prevent SARS-CoV-2-associated neuropathy. Patients with Guillain-Barré syndrome (GBS) benefit from immunoglobulins, plasma exchange, and steroids. Conclusions: Neuropathies of peripheral nerves in patients with COVID-19 are frequent and mostly result from immune mechanisms or neurotoxic side effects of drugs used to treat the symptoms of COVID-19 and, to a lesser extent, from the compression of peripheral nerves due to prolonged bedding on the ICU. SARS-CoV-2 does not cause infectious neuropathy.

Although several considerations have been raised suggesting a beneficial effect of N-acetyl cysteine (NAC) for the treatment of severe acute respiratory syndrome coronavirus 2 infection, there is currently no clinical evidence that NAC truly prevents coronavirus disease 2019 (COVID-19), reduces the severity of the disease, or improves the outcome. Appropriately designed clinical trials are warranted to prove or disprove a therapeutic effect of NAC for COVID-19 patients.

OBJECTIVES: Affection of the central nervous system and the eyes is increasingly recognized as manifestations of a SARS-CoV-2 infection (COVID-19). This review aims at summarizing and discussing recent advances concerning causes and locations of impaired vision because of an infection with SARS-CoV-2. METHODS: On a literature search through PubMed and ScholarOne, all available publications about COVID-19 patients with impaired vision were retrieved. RESULTS: Visual impairment in SARS-CoV-2-infected patients may be due to infection of lacrimal glands (dacryoadenitis), conjunctivitis, tonic pupils, vitritis, central retinal artery/venous occlusion, retinitis, retinal bleeding, panuveitis, anterior ischemic optic neuropathy, optic nerve stroke, optic neuritis, optic perineuritis, or occipital ischemic stroke. Visual impairment may be the initial manifestation of SARS-CoV-2. CONCLUSIONS: This mini review shows that impaired vision may be the initial manifestation of COVID-19, that all sections of the visual tract may be affected and causative for visual impairment in COVID-19 patients, and that SARS-CoV-2 manifests along the visual tract with ischemia, focal infection, and immunological reactions.

In aggregative games individuals’ payoffs depend on players’ own contributions (or strategies) and on the aggregate contribution of other players. The replacement function, which defines the optimal contribution of a player in an aggregate contribution, is a convenient tool to analyze aggregative games. In this paper, the replacement function is used to define an adjustment process of expectations with respect to the aggregate strategy of the game. The Nash equilibrium of the game is interpreted as the rational expectations equilibrium (REE) of the dynamical system defined by that adjustment process. The expectational stability of the REE is analyzed and its local stability is characterized in terms of the fundamentals and the REE itself. Stronger results of global stability can be obtained when the model is applied to specific aggregative games with explicit payoff functions. Examples of Cournot oligopoly and public goods provision games are presented to illustrate global stability.

The SIDDHARTINO experiment at the DAΦNE collider of INFN-LNF, the pilot run for the SIDDHARTA-2 experiment which aims to perform the measurement of kaonic deuterium transitions to the fundamental level, has successfully been concluded in July 2021. The paper reports the main results of this run, including the optimization of various components of the apparatus, among which the degrader needed to maximize the fraction of kaons stopped inside the target, through measurements of kaonic helium transitions to the 2p level. The obtained shift and width values are ε 2p = E exp − E e.m = 0.2 ± 2.5(stat) ± 2.0(syst) eV and Γ2p = 8 ± 10 eV (stat), respectively. This new measurement of the shift, in particular, represents the most precise one for a gaseous target and is expected to contribute to a better understanding of the kaon–nuclei interaction at low energy. The results obtained in this pilot run, combined with the foreseen additional veto systems and projected for the total 48 SDD arrays of the SIDDHARTA-2 final setup, represent a solid starting point for the successful measurement of the kaonic deuterium 2p → 1s transition, main goal of the experiment.

Kaonic atoms are a unique tool to explore quantum chromodynamics in the strangeness sector at low energy, with implications reaching neutron stars and dark matter. Precision X-ray spectroscopy can fully unlock the at-threshold isospin dependent antikaon-nucleon scattering lengths, via the atomic transitions to the fundamental level. While the SIDDHARTA experiment at the INFN-LNF DA$\Phi$NE collider successfully measured kaonic hydrogen, its successor SIDDHARTA-2 is starting now its data taking campaign aiming to finally fully disentangle the isoscalar and isovector scattering lengths via the measurement of kaonic deuterium. An overview of the first experimental results from a preparatory run for the SIDDAHARTA-2 experiment is presented., Comment: 13 pages, 7 figures, to be sumbitted to Phys. Scr. - Focus on New Frontiers in Physics - Selected Papers from ICNFP 2021

The nuclear E2 resonance effect occurs when an atomic de-excitation energy is closely matched by a nuclear excitation energy. It produces an attenuation of some of the atomic X-ray lines in the resonant isotope target. Investigating the nuclear E2 resonance effect in kaonic atoms, important information about kaon-nucleus strong interaction can be provided. The only K − − 42 98 Mo nuclear resonance effect was measured by G. L. Goldfrey, G- K. Lum and C. E. Wiegand at Lawrence Berkeley Laboratory, in 1975. The nuclear E2 resonance effect was observed in 25 hours of data taking, not enough to provide a conclusive result. In four kaonic Molybdenum isotopes ( 42 94 Mo , 42 96 Mo , 42 98 Mo and 42 100 Mo ), the nuclear E2 resonance effect is expected at the same transition, with similar energy values. The KAMEO (Kaonic Atoms Measuring nuclear resonance Effects Observables) experiment plans to study the E2 nuclear resonance effect in kaonic Molybdenum isotopes at the DAΦNE e+e− collider, during the SIDDHARTA-2 experiment. The experimental strategy consists of exposing four solid strip targets, each enriched with one Molybdenum isotope, to negatively charged kaons, using a germanium detector for X-ray transition measurements. A further exposure of a non-resonant 42 92 Mo isotope solid strip target will be used as reference for standard non-resonant transitions.

The SIDDHARTA-2 collaboration is aiming to perform the challenging measurement of kaonic deuterium X-ray transitions to the ground state. This will allow to extract the isospin-dependent antikaon-nucleon scattering lengths, providing input to the theory of Quantum Chromodynamics (QCD) in the non-perturbative regime with strangeness. This work describes the SIDDHARTA-2 experimental apparatus and presents the results obtained during the commissioning phase realized with kaonic helium measurements. In particular, the first observation of the kaonic helium transitions to the 3s level (M-lines), reported in this work, represents a new source of information to study the kaonic helium cascade process and demonstrates the potential of the SIDDHARTA-2 apparatus, in the view of the ambitious kaonic deuterium measurement.

Heavy metal contamination in aquatic environments plays an important role in the exposure of humans to these toxicants. Among these pollutants, mercury (Hg) is one main concern due to its high neurotoxicity and environmental persistence. Even in low concentrations, Hg bioaccumulation is a major threat to human health, with higher impact on populations whose diet has fish as chief consumption. Mercury compounds have high affinity for neuronal receptors and proteins, which gives Hg its cumulative feature and have the ability to cross cell membranes and blood–brain barrier to show their neurotoxicity. Intoxication with Hg increases levels of reactive oxygen species (ROS), thus depleting faster the resource of antioxidant proteins. To evaluate Hg-induced hippocampal ROS production, synaptic plasticity, anxiety, and memory, a total of 11 male Wistar rats were exposed to HgCl2 (Hg30 group) to produce a residual concentration of 8 ng/mL at the end of 30 days. Behavioral tests (plus-maze discriminative avoidance task), in vitro electrophysiology, and ROS assays were performed. Western blot assay showed decreased levels of antioxidant proteins GPx and SOD in Hg30 group. Increased ROS production was observed in the CA1 and CA3 regions in the Hg-exposed group. Plus-maze task detected long-term memory impairment in Hg30 group, linked to poorer in vitro long-term potentiation as compared to control group. Hg intoxication also promoted higher anxiety-like behavior in the exposed animals. In conclusion, our data suggests that low doses of HgCl2 resulted in impaired long-term memory and unbalance between decreased antioxidant protein expression and increased ROS production in the hippocampus.

The SIDDHARTA-2 experiment at the DAΦNE collider aims to perform the first kaonic deuterium x-ray transitions to the fundamental level measurement, with a systematic error at the level of a few eV. To achieve this challenging goal the experimental apparatus is equipped with 384 Silicon Drift Detectors (SDDs) distributed around its cryogenic gaseous target. The SDDs developed by the SIDDHARTA-2 collaboration are suitable for high precision kaonic atoms spectroscopy, thanks to their high energy and time resolutions combined with their radiation hardness. The energy response of each detector must be calibrated and monitored to keep the systematic error, due to processes such as gain fluctuations, at the level of 2–3 eV. This paper presents the SIDDHARTA-2 calibration method which was optimized during the preliminary phase of the experiment in the real background conditions of the DAΦNE collider, which is a fundamental tool to guarantee the high precision spectroscopic performances of the system over long periods of data taking, as that required for the kaonic deuterium measurement.

The involvement of cranial nerves is being increasingly recognised in COVID-19. This review aims to summarize and discuss the recent advances concerning the clinical presentation, pathophysiology, diagnosis, treatment, and outcomes of SARS-CoV-2 associated cranial nerve mononeuropathies or polyneuropathies. Therefore, a systematic review of articles from PubMed and Google Scholar was conducted. Altogether 36 articles regarding SARS-CoV-2 associated neuropathy of cranial nerves describing 56 patients were retrieved. Out of these 56 patients, cranial nerves were compromised without the involvement of peripheral nerves in 32 of the patients, while Guillain-Barre syndrome (GBS) with cranial nerve involvement was described in 24 patients. A single cranial nerve was involved either unilaterally or bilaterally in 36 patients, while in 19 patients multiple cranial nerves were involved. Bilateral involvement was more prevalent in the GBS group (n=11) as compared to the cohort with isolated cranial nerve involvement (n=5). Treatment of cranial nerve neuropathy included steroids (n=18), intravenous immunoglobulins (IVIG) (n=18), acyclovir/valacyclovir (n=3), and plasma exchange (n=1). The outcome was classified as “complete recovery” in 21 patients and as ”partial recovery” in 30 patients. One patient had a lethal outcome. In conclusion, any cranial nerve can be involved in COVID-19, but cranial nerves VII, VI, and III are the most frequently affected. The involvement of cranial nerves in COVID-19 may or may not be associated with GBS. In patients with cranial nerve involvement, COVID-19 infections are usually mild. Isolated cranial nerve palsy without GBS usually responds favorably to steroids. Cranial nerve involvement with GBS benefits from IVIG.