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1. A rare case of symptomatic creatine kinase elevation in a patient with rheumatoid arthritis treated with baricitinib

Author: F.M. Mariani, A. Alunno, F. Carubbi, and C. Ferri
Subjects: Case report, rheumatoid arthritis, baricitinib, creatine kinase, myalgia, Medicine, Internal medicine, RC31-1245
Abstract: The safety profile of baricitinib (BARI), a Janus kinase inhibitor broadly used for the treatment of rheumatoid arthritis (RA), includes asymptomatic laboratory abnormalities, such as an increase in creatine kinase (CK). Data from randomized controlled trials suggest that concomitant myalgia is rare in RA and does not lead to drug discontinuation. We describe the case of a 68-year-old Caucasian female with longstanding, multi-failure RA who started BARI and achieved disease remission. However, she developed a symptomatic CK increase, as well as a parallel increase in total cholesterol, low-density lipoprotein, and triglycerides. Dechallenge-rechallenge demonstrated a plausible relationship between the clinical/laboratory abnormalities and BARI. In fact, when the drug was withdrawn, CK returned to normal and myalgia disappeared, whereas symptoms returned and CK levels increased when BARI was restarted. BARI may be rarely associated with symptomatic CK elevation, and this may pose clinical challenges, particularly for patients with multi-failure RA who achieved good disease control with BARI but required drug discontinuation due to intolerance.
Published: 2024
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2. Prolonged COVID 19 Outbreak and Psychological Response of Nurses in Italian Healthcare System: Cross-Sectional Study

Author: Jessica Ranieri, Federica Guerra, E. Perilli, Domenico Passafiume, D. Maccarone, C. Ferri, and Dina Di Giacomo
Subjects: clinical psychology, nurse, COVID-19, psychological traits, personality traits, healthcare worker, Psychology, BF1-990
Abstract: Aim of the study was to analyze the posttraumatic stress disorder risk nurses, detecting the relationship between distress experience and personality dimensions in Italian COVID-19 outbreak. A cross-sectional study was conducted based on 2 data detection (March 2020 and September 2020). Mental evaluation was carried out in Laboratory of Clinical Psychology on n.69 nurses in range age 22–64 years old (mean age 37.3; sd ± 10.3; 55% working in nursing care with confirmed COVID-19 patients (named frontline; secondline nurses have been identified by nursing care working with infectious patients but no confirmed COVID-19). Measurement was focused on symptoms anxiety, personality traits, peritraumatic dissociation and post-traumatic stress for all participants. No online screening was applied. Comparisons (ANOVA test) within the various demographic characteristics demonstrated few significant differences between groups on DASS-21, PDEQ, and ISE-R scores. Correlation analysis (Spearman test) was performed among PDEQ, DASS-21, BFI-10 and IES-R and confirmed between anxiety (DASS-21) and peritraumatic dissociation and post-traumatic stress; then anxiety is positively correlated to agreeableness variable of BFI-10 test. The emotional distress was protracted overtime (after 6 months) but in long-term personality traits resulted mediator facing subjective stress. Our finding drew details for protective and predictive risk factors as well as mental health issues of nurses dealing with pandemic: healthcare workers faced the protracted challenge caring COVID-19 patients over and over again: in short time the impact was relevant, and the prolonged exposition to the stressor was tackled by personal resources such as personality traits.
Published: 2021
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3. Prevalence and incidence of osteoporotic fractures in patients on long-term glucocorticoid treatment for rheumatic diseases: the Glucocorticoid Induced OsTeoporosis TOol (GIOTTO) study

Author: M. Rossini, O. Viapiana, M. Vitiello, N. Malavolta, G. La Montagna, S. Maddali Bongi, O. Di Munno, R. Nuti, C.U. Manzini, C. Ferri, L. Bogliolo, A. Mathieu, F. Cantatore, A. Del Puente, M. Muratore, W. Grassi, B. Frediani, G. Saviola, P. Delvino, L. Mirone, G. Ferraccioli, G. Tripi, I. Piazza, and D. Gatti
Subjects: Glucocorticoids, rheumatic diseases, osteoporosis, fractures., Medicine, Internal medicine, RC31-1245
Abstract: Osteoporosis and fractures are common and invalidating consequences of chronic glucorticoid (GC) treatment. Reliable information regarding the epidemiology of GC induced osteoporosis (GIOP) comes exclusively from the placebo group of randomized clinical trials while observational studies are generally lacking data on the real prevalence of vertebral fractures, GC dosage and primary diagnosis. The objective of this study was to evaluate the prevalence and incidence of osteoporotic fractures and to identify their major determinants (primary disease, GC dosage, bone mineral density, risk factors, specific treatment for GIOP) in a large cohort of consecutive patients aged >21 years, on chronic treatment with GC (≥5 mg prednisone - PN - equivalent) and attending rheumatology centers located all over Italy. Glucocorticoid Induced OsTeoporosis TOol (GIOTTO) is a national multicenter cross-sectional and longitudinal observational study. 553 patients suffering from Rheumatoid Arthritis (RA), Polymyalgia Rheumatica (PMR) and Connective Tissue Diseases (CTDs) and in chronic treatment with GCs were enrolled. Osteoporotic BMD values (T score
Published: 2017
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4. Paraneoplastic rheumatic disorders: a narrative review

Author: C.U. Manzini, M. Colaci, C. Ferri, and E. Manzini
Subjects: Paraneoplastic syndromes, Rheumatic diseases, Tumors., Medicine, Internal medicine, RC31-1245
Abstract: Paraneoplastic syndromes (PS) are a heterogeneous group of diseases related to a neoplasm, indirectly dependent on it. Diagnosis and the treatment are often a challenge for clinicians, not least because the pathogenetic mechanisms are highly complex and not entirely known. Nonetheless, in most cases, PS precede the diagnosis of malignancies, thus their identification is particularly important in addressing physicians’ diagnostic work-up with regard to early cancer diagnosis. Among paraneoplastic syndromes, those of rheumatologic interest represent a large component. In this paper, we review the main rheumatic PS.
Published: 2018
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5. Predictive value of isolated DLCO reduction in systemic sclerosis patients without cardio-pulmonary involvement at baseline

Author: M. Colaci, D. Giuggioli, M. Sebastiani, A. Manfredi, F. Lumetti, F. Luppi, S. Cerri, and C. Ferri
Subjects: Scleroderma, systemic sclerosis, DLCO, pulmonary arterial hypertension, lung fibrosis., Medicine, Internal medicine, RC31-1245
Abstract: Impaired diffusing capacity of the lung for carbon monoxide (DLCO) was frequently observed in systemic sclerosis (SSc) patients, generally related to the presence of interstitial lung disease (ILD) and/or pulmonary arterial hypertension (PAH). However, in clinical practice abnormally low DLCO values may be found also in the absence of these SSc complications. The objective was to investigate the prospective clinical relevance of isolated DLCO reduction at baseline in SSc patients. Ninety-seven SSc female patients (age at the diagnosis: 51.3±14.5 years; disease duration: 10.4±6.6 years; limited/diffuse skin subsets: 92/5), without any clinical, radiological (high resolution computed tomography), and echocardiographic manifestations of ILD or PAH at baseline, nor other lung or heart diseases able to affect DLCO, were recruited at our Rheumatology Centre. Patients with DLCO
Published: 2016
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6. Haematological Malignancies in Systemic Sclerosis Patients: Case Reports and Review of the World Literature

Author: M. Colaci, D. Giuggioli, C. Vacchi, and C. Ferri
Subjects: Diseases of the musculoskeletal system, RC925-935
Abstract: Background. The association of systemic sclerosis (SSc) and haematological cancers was reported in a large number of case reports and cohort studies, describing SSc patients with highly heterogeneous clinical pictures. Objective. We reviewed the literature to better describe SSc patients with haematological malignancies. Methods. SSc cases complicated by haematological malignancies described in the world literature were collected; other 2 cases referred to our centre were reported. Results. One hundred-thirty SSc subjects were collected from 1954 up to date. The mean age of patients at cancer diagnosis was 56.1 ± 16.7 years; 72% of patients were females. In 60% of cases, the diagnosis of haematological malignancy was described within 5 years of SSc diagnosis. In 7.8% of cases, coexistence of Sjögren’s syndrome or other autoimmune disorders was cited. Sixty-six cases with lymphoma (in the majority of cases B-cell neoplasms), 28 with leukaemia (chronic lymphocytic form in 9), 14 with multiple myeloma plus one solitary IgM plasmocytoma, and 16 with myeloproliferative disorders were found. No specific SSc subsets seem to be related to haematological malignancies. Conclusions. We remarked the importance of clinical work-up in SSc, in order to early diagnose and treat eventual occult haematological malignancies, especially during the first years of the disease.
Published: 2017
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7. Systematic review of 2008-2012 literature and update of recommendations for the use of methotrexate in rheumatic diseases, with a focus on rheumatoid arthritis

Author: M. Todoerti, W. Maglione, E. Bernero, A. Bortoluzzi, M. Colaci, E. Galuppi, S. Paolino, R. Talarico, M. Cutolo, C. Ferri, F. Trotta, S. Bombardieri, C.M. Montecucco, and L. Sinigaglia
Subjects: Recommendations, Evidence-based medicine, Methotrexate, Rheumatoid arthritis, Rheumatic diseases., Medicine, Internal medicine, RC31-1245
Abstract: The objective of this review is to update the recommendations of the 2010 Italian Consensus on the use of methotrexate (MTX) in rheumatoid arthritis (RA) and other rheumatic diseases. The literature published between 2008 and 2012 was systematically reviewed and updated recommendations on MTX use in rheumatic diseases, particularly RA, were formulated. These recommendations were approved by a panel of expert Italian Rheumatologists. A total of 10,238 references were identified, among which 70 studies were selected for critical evaluation. Sufficient evidence had accumulated to warrant changes to several of the recommendations in the new version. A new recommendation for patients with RA who are in MTX-induced clinical remission was also proposed and approved by the panel. Updated recommendations for the use of MTX in patients with RA or other rheumatologic disease are proposed.
Published: 2013
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8. Aortic pulse wave velocity measurement in systemic sclerosis patients

Author: M. Sebastiani, F. Coppi, A. Manfredi, D. Giuggioli, M. Colaci, R. Rossi, and C. Ferri
Subjects: pulse wave velocity, scleroderma, systemic sclerosis, pulmonary arterial hypertension, arterial stiffness, Medicine, Internal medicine, RC31-1245
Abstract: Background. Systemic sclerosis (SSc) is characterized by endothelial dysfunction and widespread microangiopathy. However, a macrovascular damage could be also associated. Aortic pulse wave velocity (aPWV) is known to be a reliable indicator of arterial stiffness and a useful prognostic predictor of cardiovascular events. Moreover, aPWV may be easily measured by non-invasive, user-friendly tool. Aim of our study was to evaluate aPWV alterations in a series of SSc patients. Methods. The aPWV was evaluated in 35 consecutive female SSc patients and 26 sex- and age-matched healthy controls. aPWV alterations were correlated with cardiopulmonary involvement. Results. A significant increase of aPWV was observed in SSc patients compared to controls (9.4±3.2 m/s vs 7.3±1 m/s; P=0.002). In particular, 14/35 (40%) SSc patients and only 1/26 (4%) controls (P=0.0009) showed increased aPWV (>9 m/s cut-off value). Moreover, echocardiography evaluation showed an increased prevalence of right atrial and ventricular dilatation (atrial volume: 23.6±6.2 mL vs 20.3±4.3 mL, P=0.026; ventricular diameter 19.5±4.9 mm vs 15.9±1.6 mm; P=0.001) associated to higher values of pulmonary arterial systolic pressure (PAPs) in SSc patients (31.5±10.4 mmHg vs 21.6±2.9 mmHg; P50 years old. Furthermore, altered aPWV was more frequently associated with limited cutaneous pattern, longer disease duration (≥5 years), and/or presence of anticentromere antibody (ACA). Conclusions. A significantly higher prevalence of abnormally increased aPWV was evidenced in SSc patients compared to healthy controls. The possibility of more pronounced and diffuse vascular damage in a particular SSc subset (ACA-positive subjects with limited cutaneous scleroderma and longer disease duration) might be raised.
Published: 2012
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9. The pathogenesis of the anaemia of chronic disorders

Author: C. Ferri, E. Manzini, and C.U. Manzini
Subjects: anaemia of chronic disorders, hepcidin, proinflammatory cytokines, Medicine, Internal medicine, RC31-1245
Abstract: Anemia of chronic disorders is a typical condition of infective, immunological and neoplastic diseases. Hepcidin and proinflammatory cytokines play a leading role in its pathogenesis. Hepcidin is a hormone produced by the liver that controls iron metabolism. It ensures that iron is retained by enterocytes (where the metal is absorbed) and by macrophages (that store the iron that results from the physiological breakdown of erythrocytes). Cytokines play a role in hepcidin synthesis, and in the proliferation and the maturation of the erythroid components within bone marrow. This paper discusses the pathogenetic mechanisms of anemia in chronic disorders.
Published: 2012
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10. GISEA: an Italian biological agents registry in rheumatology

Author: F. Trotta, L. Punzi, C. Ferri, G. Ferraccioli, and G. Lapadula
Subjects: Biological agents, observational study, real-world practice, Medicine, Internal medicine, RC31-1245
Abstract: The GISEA registry is an independent database that was established by the Italian Group for the Study of Early Arthritis (GISEA) in 2008, funded by the Italian Association of Rheumatic Patients (ANMAR - ONLUS). In line with the network’s epidemiological strategy, the initial protocol was designed to collect long-term follow-up data concerning patients with rheumatic diseases treated with biological agents in order to investigate the realworld characteristics in terms of disease activity, comorbidities and survival on treatment. We here describe the design and methodology used to collect patient data. Information concerning demographics, disease activity, treatment changes (including the reasons for changing and the duration of each therapy), concomitant therapies and adverse events is available to all the members of the study groups by means of a web-based interface that allows queries and the presentation of numerical data, as well as graphics to illustrate trends. Fourteen Italian rheumatology centres have contributed patients to the database which, at the time writing, includes 5145 patients (72% women) with a mean age of 53 years (range 16-88). The initial diagnoses were rheumatoid arthritis (3494 patients, 67.9%), psoriatic arthritis (833, 16.2%), ankylosing spondylitis (493, 9.6%), undifferentiated spondylo-arthritides (307, 5.9%), enteropathic arthritis (14, 0.3%) and spondylitis following reactive arthritis (4, 0.1%). These patients have been followed for up to 10 years, and 1927 (35.8%) have been treated for at least three years. The biological treatments received include etanercept, infliximab, anakinra, adalimumab, abatacept, rituximab and tocilizumab. A total of 2926 adverse events have been observed, with 1171 patients (22%) reporting at least one. Analysis of the accumulated data will provide insights into the critical early phase of the studied arthritides, and enable us to identify the clinical and laboratory profiles that may predict responsiveness to a specific therapy.
Published: 2011
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11. Correlation of a quantitative videocapillaroscopic score with the development of digital skin ulcers in scleroderma patients

Author: A. Antonelli, N. Elkhaldi, R. La Sala, D. Giuggioli, M. Colaci, A. Manfredi, M. Sebastiani, and C. Ferri
Subjects: Medicine, Internal medicine, RC31-1245
Abstract: Background: Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of the skin and visceral organs. The microangiopathy is early detectable in the course of the disease by nailfold videocapillaroscopy (NVC), a non-invasive technique with a high diagnostic value. Objective: Aim of our study was to evaluate the feasibility of a quantitative score and its correlation with the digital skin ulcers, which frequently complicate SSc microangiopathy. Methods: We retrospectively analysed the NVC of 65 SSc patients, performed by 200x videocapillaroscopy connected to image analyse software (Videocap; DS MediGroup, Milan, Italy). The analysis of NVC images included: total number of capillaries in the distal row (N), maximum diameter (D) and number of giant capillaries (M), M/N ratio and percentage of M, presence/absence of micro-haemorrhages and tortuosity. Results: 21/65 SSc patients experienced digital ulcers within three months after the NVC examination. The N, D, M/N, and percentage of M significantly correlated with the appearance of ischemic ulcers. A multiple regression analysis showed a statistically significant correlation for N, M/N and D, while sensitivity and specificity of these parameters were unsatisfactory. A capillaroscopic score, according to the formula D·M/N2, showed a high specificity and sensibility (93.2% and 85.7% respectively; area under ROC curve: 0.918) to predict the appearance of digital ulcers. Conclusions: This capillaroscopic score may represent a feasible and simple tool in SSc patients’ assessment. The routinely use of this parameter might permit to recognize and to preventively treat SSc patients at high risk to develop digital ulcers.
Published: 2011
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12. Fibronectin gene polymorphisms and clinical manifestations of mixed cryoglobulinemic syndrome: increased risk of lymphoma associated to MspI DD and HaeIII AA genotypes

Author: C. Fabro, A. Lerussi, S. Salvin, C. Ferri, A. Tavoni, C. Mazzaro, G. Pozzato, V. De Re, L. Quartuccio, M. Fabris, S. Bombardieri, and S. De Vita
Subjects: Medicine, Internal medicine, RC31-1245
Abstract: Objective: To analyse FN gene polymorphisms in type II mixed cryoglobulinemic syndrome (MCsn), an immune-complex mediated systemic vasculitis linked to hepatitis C virus (HCV) infection and characterized by rheumatoid factor (RF) positive B-cell proliferation at high risk for the progression into non Hodgkin’s lymphoma (NHL). Methods: Samples from eighty-one patients, with MCsn (type II serum cryoglobulins and clinical signs of vasculitis) were studied. Sixthy-five (65/81, 80.3%) patients were HCV-positive. Twenty-one (25.9%) patients had developed a B-cell NHL during the course of MCsn. Seventy-two patients with HCV-negative and MC-unrelated NHL and 110 healthy blood donors (HBDs) were taken as controls. HaeIIIb and MspI FN gene polymorphisms were analysed by PCR and specific restriction enzyme digestions, following reported procedures. Plasma FN levels were analysed by ELISA, whenever possible. Results: HaeIIIb and MspI allele and genotype frequencies did not differ between MCsn patients and HBDs. Of note, the DD-MspI (OR=5.56; CI=1.67-18.51, p=0.0046) and the AA-HaeIIIb (OR=5.54; CI=1.64-18.76, p=0.0066) homozygosis appeared significantly and independently associated with the development of B-cell NHL in MCsn patients, with the HaeIIIb A allele possibly conferring an increased risk of NHL in the general population (OR=1.72, CI=1.128- 2.635, p=0.0133). In contrast, the major vasculitic manifestations, such as peripheral neuropathy, skin ulcers and glomerulonephritis tended to be associated with the counterpart MspI C allele. No association between FN plasma levels and FN genotypes was found. Conclusion: Genotyping for MspI and HaeIIIb FN gene polymorphisms may be clinically relevant to define the predisposition to the major clinical manifestations in MCsn.
Published: 2011
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13. Percutaneous vertebroplasty as therapy of vertebral fractures: results in a series of osteoporotic patients

Author: F. Cavallari, S. Vallone, L. Bernini, C.U. Manzini, and C. Ferri
Subjects: Medicine, Internal medicine, RC31-1245
Abstract: In the recent years, percutaneous vertebroplasty is available for the treatment of the vertebral fractures, primarily to relieve pain related to the lesion. In order to evaluate the efficacy and the safety of this technique, we have treated with percutaneous vertebroplasty, using polymethil-methacrylate, 22 patients, affected by one or more vertebral fractures caused by osteoporosis. All the patients satisfied the inclusion criteria of the American College of Radiology for percutaneous vertebroplasty. These patients were compared with a control group of 23 not treated subjects with vertebral fractures, using questionnaires for assessment of pain and quality of life, drug intake, use of corset, and tolerability of the surgery. In the large majority of patients, the treatment of osteoporotic vertebral fractures with percutaneous vertebroplasty resulted in a prompt, marked and sustained relief of vertebral pain with a persistent improvement of quality of life.
Published: 2011
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14. Treatment patterns of snti-TNF agents in Italy: an observational study

Author: C. Ferri, U. Fiocco, G. Bagnato, F. Cantini, M. Matucci Cerinic, L. Punzi, and S. Bombardieri
Subjects: Medicine, Internal medicine, RC31-1245
Abstract: Rheumatoid arthritis is the most common form of chronic infl ammatory rheumatism. This autoimmune disease leads to progressive joint damage, functional disability, impaired quality of life and, in some cases, shortened life expectancy.
Published: 2011
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15. Gynaecological Screening for Cervical and Vulvar Malignancies in a Cohort of Systemic Sclerosis Patients: Our Experience and Review of the Literature

Author: M. Colaci, D. Giuggioli, G. Cassone, C. Vacchi, F. Campomori, F. Boselli, M. Sebastiani, A. Manfredi, and C. Ferri
Subjects: Diseases of the musculoskeletal system, RC925-935
Abstract: Background. Increased incidence of cancer was frequently reported in scleroderma (SSc), but no association with gynaecological malignancies was described in literature. Objectives. To investigate gynaecological neoplasms in SSc patients. Methods. In this cross-sectional analysis, we evaluated 80 SSc patients, living in the same geographical area. We considered all patients undergoing gynaecological evaluation, including pap test as screening for cervical cancer, between January 2008 and December 2014. Results. 55 (68.7%) patients were negative and 20 (25%) presented inflammatory alterations, while cancer or precancerous lesions were found in 5 (6.2%) cases (2 showed cervical cancer (one of them in situ), 1 vulvar melanoma, 1 vulvar intraepithelial neoplasia, and 1 endocervical polyp with immature squamous metaplasia). The frequency of cervical cancer in our series seems higher in comparison to the incidence registered in the same geographical area. The presence of atypical cytological findings correlated with anti-Scl70 autoantibodies (p = 0.022); moreover, the patients with these alterations tended to be older (median 65, range 46–67), if compared to the whole series (p = 0.052). Conclusions. A relatively high frequency of gynaecological malignancies was found in our SSc series. In general, gynaecological evaluation for SSc women needs to be included in the routine patients’ surveillance.
Published: 2015
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16. Dactilitis and oligoarthritis after BCG immunotherapy in a patient affected by bladder cancer

Author: N. Elkhaldi, L. Bernardini, C.U. Manzini, M.T. Mascia, and C. Ferri
Subjects: Medicine, Internal medicine, RC31-1245
Abstract: The treatment of bladder cancer with Bacillus of Calmette-Guerin (BCG) immunotherapy can induce the appearance of a reactive disorder. The Authors describe a 55-year-old male patient with bladder cancer treated with endovesical instillation of BCG immunotherapy, followed after the fifth application by asymmetric oligoarthritis and dactilitis. The observed positivity of both HLA-B27 and HLA-B51 antigens reinforces the hypothesis of a reactive form, possibly through "molecular mimicry" mechanism. The discontinuation of BCG instillation along which a therapeutic attempt with NSAD failed to improve the rheumatic manifestation, which completely remitted after a four-month course of oral steroids. No relapses of joint and tendon involvement was observed during the following five-month period. The clinico- pathogenetic implications suggested by this case are discussed.
Published: 2011
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17. Patients with Mixed Cryoglobulinemia and HCV Infection, in Presence or Absence of Autoimmune Thyroiditis, Have High Serum Levels of (CXC MOTIF) Ligand (CXCL)9 and CXCL11 Chemokines

Author: A. Antonelli, P. Fallahi, S.M. Ferrari, S. Frascerra, A. Corrado, M. Colaci, A. Manfredi, M. Maccheroni, D. Sansonno, A.L. Zignego, M. Centanni, and C. Ferri
Subjects: Medicine
Abstract: No data are present in the literature regarding chemokine (CXC motif) ligand (CXCL)9 and CXCL11 circulating levels in cryoglobulinemia associated with hepatitis C (MC+HCV), in presence/absence of autoimmune thyroiditis (AT). Serum CXCL9 and CXCL11 have been measured in 38 MC+HCV patients without AT (MCo), 38 MC+HCV patients with AT (MC+AT), and in matched controls without (control 1) or with thyroiditis (control 2). Serum CXCL9 and CXCL11 were significantly higher: in control 2 than control 1 ( p
Published: 2012
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18. Hepatitis C is Associated with High Levels of Circulating N-Terminal Pro-Brain Natriuretic Peptide and Interleukin-6

Author: A. Antonelli, C. Ferri, S.M. Ferrari, A. Di Domenicantonio, C. Mancusi, S. Marchi, N. De Bortoli, M.R. Metelli, F. Bruschi, and P. Fallahi
Subjects: Medicine
Abstract: To our knowledge, no study has evaluated N-terminal pro-brain natriuretic peptide (NTproBNP) together with interleukin-6 (IL-6) and interferon (IFN)-gamma serum levels in a large series of patients with hepatitis C virus (HCV) as possible markers of cardiac dysfunction. NTproBNP and IL-6 serum levels were valued in 55 HCV-patients, and in 55 sex- and age-matched controls. HCV-patients showed significantly higher mean NTproBNP and IL-6 levels than controls ( P = 0.001); no significant difference was observed for IFN-gamma. By defining high NTproBNP level as a value higher than 300 pg/mL (that is used to rule out heart failure in patients under 75 years of age), 12% (6/49) of HCV-patients and 0 of controls had NTproBNP (χ 2 ; P = 0.012). In conclusion, this study demonstrates high levels of circulating NTproBNP and IL-6 in HCV-patients. The increase of NTproBNP may indicate the presence of a subclinical cardiac dysfunction. Further prospective studies quantifying symptoms and correlating these with echocardiography parameters are needed to confirm this association.
Published: 2012
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19. Diffuse post-traumatic calcification of the anterior longitudinal ligamentum of cervical and dorsal spine

Author: C.U. Manzini, V. Spina, M.T. Mascia, R. Magistro, G. Carpenito, and C. Ferri
Subjects: Medicine, Internal medicine, RC31-1245
Abstract: Among the different conditions causing flogosis and calcification/ossification of the soft tissues of the spinal cord, single or recurrent traumatic events are included. Within the international literature, the involvement of the posterior longitudinal ligament, following spinal cord injuries is frequently reported, especially in the elders. The Authors describe here an uncommon calcification/ossification of the anterior longitudinal ligament occurred after a double traumatic event in a young man, followed clinically and radiologically for a long-term period. On the basis of clinical, bioumoral and radiological findings, the differential diagnosis with other possible aetiologies, especially DISH (Diffuse idiopathic skeletal hyperostosis) and ankylosing spondylitis, is discussed.
Published: 2004
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20. Chromosome aberrations, valued as frequency of spontaneous micronuclei, in subjects with suspected presclerodermic Raynaud’s phenomenon

Author: G. Porciello, R. Scarpato, F. Storino, F. Cagetti, F. Bellisai, G. Morozzi, R. Marcolongo, L. Migliore, C. Ferri, and M. Galeazzi
Subjects: Medicine, Internal medicine, RC31-1245
Abstract: Objective: To evaluate the prevalence of spontaneous chromosome damage in cultured peripheral lymphocytes of subjects with suspected presclerodermic Raynaud’s phenomenon (RP), by means of molecular cytogenetic analysis. Methods: We studied 20 suspected presclerodermic RP, 20 idiopathic RP and 25 healthy subjects. As marker of chromosome alteration we used the micronucleus assay. All subjects were also classified as ANA-, ACA+ or Scl70+. To identify the mechanism of MN formation, a MN fluorescence in situ hybridisation (FISH) analysis using a pancentromeric DNA probe was also performed. Results: Suspected presclerodermic RP subjects, showed significantly higher MN frequencies than idiopathic RP and controls (39±15.2 vs 10±2.1 and 9.8±3.5 respectively p
Published: 2003
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21. A clinico-serological investigation of arthritis in patients with or without cryoglobulinemic syndrome

Author: P. Fadda, L. La Civita, A.L. Zignego, and C. Ferri
Subjects: Medicine, Internal medicine, RC31-1245
Abstract: Objective: To compare the clinico-serological features of arthritis from two HCV+ patient groups characterised by mixed cryoglobulinemia (MC) or chronic hepatitis (CH). Methods: We retrospectively studied 157 MC patients (119 females, mean age 64.8 yrs, range 36-88) and 155 CH patients (103 females, mean age 58.8 yrs, range 30-81). Patients with HBV and/or HIV co-infections and a follow-up shorter than 1 year were excluded. MC was classified according to standard criteria, while CH classification was based on Desmet’s criteria. Results: No differences in epidemiology were demonstrated between the two series of patients. Although significantly prevalent in MC patients, extra-hepatic manifestations including nephropathy, neuropathy, pneumopathy, mixed cryoglobulins, RF positivity and hypocomplementemia were detected in both patient groups. Arthritis was present in 23 CH (15%) and 12 MC (8%) patients. A symmetrical polyarthritis was observed in 87% of 23 CH patients, while cryoglobulinemic arthritis was invariably asymmetrical and pauciarticular. Unlike MC patients, who had a constantly nonerosive arthritis, in 7/23 CH patients arthritis was erosive. Steroids and/or hydroxycloroquine or D-penicillamine were safe and useful in controlling the arthritis over the short-medium time, although clinical response was more evident in MC patients. Instead, in 5/23 CH and 3/12 MC patients, interferon-alpha treatment was able to trigger or exacerbate the arthritis despite a good control of liver function. Conclusions: HCV infection seems to be, possibly in genetically predisposed patients, responsible for arthritis at times similar to rheumatoid arthritis. In these patients a careful assessment of the interferon-alpha treatment is mandatory owing to the potential ‘arthritogenic effect’ due to its immunoregulatory properties.
Published: 2002
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22. The high frequency of spontaneous micronuclei observed in lymphocytes of systemic sclerosis patients: preliminary results

Author: G. Porciello, R. Scarpato, F. Storino, F. Cagetti, R. Marcolongo, L. Migliore, C. Ferri, and M. Galeazzi
Subjects: Medicine, Internal medicine, RC31-1245
Abstract: Objective: aim of the study is to assess the presence of spontaneous chromosome damage in patients affected by limited (lSSc) or diffuse (dSSc) Systemic Slerosis, using the micronucleus (MN) assay. Methods: we evaluated MN frequency in cultured peripheral lymphocytes of 18 SSc and in a group of 20 healthy controls. Patients were also classified as ACA+, Scl70+, FAN+ according to the presence of the specific anti-nuclear antibodies. We also explored the hypothesis that the extent of cytogenetic alteration might be related to the severity of the pathological condition and/or to the immunological profile. Results: compared to controls, the patient group as a whole showed significantly higher MN frequencies (10.8±4.5 vs. 27.8±13.7, p
Published: 2002
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23. Emergence of rifampicin-resistant staphylococci on the skin and nose of rifampicin-treated patients with an orthopaedic-device-related infection

Author: A. Wallimann, Y. Achermann, C. Ferris, M. Morgenstern, M. Clauss, V. Stadelmann, H. A. Rüdiger, L. O'Mahony, and T. F. Moriarty
Subjects: Orthopedic surgery, RD701-811
Abstract: Rifampicin is a key antibiotic in the treatment of staphylococcal biofilm infections. In this pilot study, we found that patients who received rifampicin for treatment of an orthopaedic-device-related infection (ODRI) were colonized with rifampicin-resistant staphylococci during treatment and this persisted for up to 2 months after cessation of treatment.
Published: 2024
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24. Aspectos morfológicos macroscópicos, ecometria e tonometria de rebote do bulbo ocular em bicho-preguiça (Bradypus variegatus)

Author: Marleyne José Afonso Accioly Lins Amorim, Fabrício Bezerra de Sá, Priscilla Virginio de Albuquerque, Gilcifran Prestes de Andrade, Lucilo Bioni da Fonseca Filho, Richelle da Silva Braz, Elayne Cristine Soares da Silva, and Rinaldo C. Ferri
Subjects: Intraocular pressure, genetic structures, 040301 veterinary sciences, eye bulb, ocular anatomy, xenartros, Veterinary medicine, Bradypus variegatus, anatomia ocular, Macroscopy, ocular ultrasonography, 0403 veterinary science, ecometry, 03 medical and health sciences, bicho-preguiça, 0302 clinical medicine, morphology, SF600-1100, medicine, oftalmologia, xenarthros, Morfologia, tonometry, Retina, General Veterinary, biology, business.industry, Histology, 04 agricultural and veterinary sciences, Anatomy, biology.organism_classification, eye diseases, ophthalmology, medicine.anatomical_structure, macroscopia, sloth, Lens (anatomy), Vitreous chamber, ecometria, ultrassonografia ocular, 030221 ophthalmology & optometry, Conjunctival sac, rebound tonometry, bulbo ocular, sense organs, Eyelid, business, tonometria de rebote
Abstract: The field related to the visual system of wild animals is deeply scarce. Settling anatomical and physiological parameters for these animals is still a descriptive vision for Bradypus variegatus (Schinz, 1825). Thus, our research aimed to determine patterns of normal eye for this species. For this purpose, eight eye bulbs were dissected from the carcasses obtained by natural death, and then performed an overview of ocular anatomical. Rebound tonometry (RBT) and ocular B-mode ultrasonography were also applied for eight eyes in four animals from “Parque Estadual Dois Irmãos”, situated in the city of Recife, state of Pernambuco (PE), to estimate the intraocular pressure and ocular ecobiometry. The ocular morphology of sloth is similar as described for other species, however, with some peculiarities. They present a third eyelid emerging in the nasal region of the inferior conjunctival sac and retina and also contain little differentiated blood vessels. Medium the intraocular pressure (IOP) was 4.25mmHg with no difference for both eyes. Ultrasonography of ocular anatomy is also similar regarding other species. Ecobiometric patterns were evaluated to determine the anterior chamber depth, lens width, vitreous chamber depth, and axial length (AL) of ocular globe and the averaged as shown 0.63±1.11mm, 3.73±0.24mm, 6.15±0.41mm, 3.70±0.27mm, and 8.48±0.22mm, respectively. There was no difference between the right and left eyes. The RBT and ocular B-mode ultrasonography are fast exams and easy for animal testing. This study contributed to the characterization of ocular anatomy as well as settling medium values of IOP and intraocular measures; however, further research on physiology and histology is necessary to better understand the visual function of the species. RESUMO: O campo de estudo relacionado ao sistema visual de animais silvestres é muito escasso. Estabelecer parâmetros anatômicos e fisiológicos para estes animais ainda está restrito a uma visão descritiva, assim ocorre em Bradypus variegatus (Schinz, 1825). Diante deste fato, objetivou-se com este estudo determinar padrões de normalidade oftálmica nesta espécie. Para isto foram dissecados oito bulbos oculares de cadáveres obtidos por morte natural e realizada a descrição anatômica ocular. Além disso, foram realizadas tonometria de rebote (TonoVet®) e ultrassonografia em modo B em oito olhos de quatro animais provenientes do Parque Estadual Dois Irmãos, Recife/PE, para avaliação da pressão intraocular e realização da ecobiometria ocular. A anatomia ocular do bicho-preguiça é semelhante à descrita para outras espécies com algumas particularidades. Apresentam uma terceira pálpebra emergindo na região nasal do saco conjuntival inferior e retina com vasos sanguíneos pouco diferenciados. A pressão intraocular média foi de 4,25mmHg não havendo diferença entre os olhos direito e esquerdo. A anatomia ocular ultrassonográfica é semelhante à encontrada para outras espécies. Os padrões ecobiométricos obtidos foram: profundidade da câmara anterior, espessura do cristalino, diâmetro do cristalino, profundidade da câmara vítrea e comprimento axial do bubo ocular com tamanhos médios de 0,63±1,11mm, 3,73±0,24mm, 6,15±0,41mm, 3,70±0,27mm e 8,48±0,22mm, respectivamente. Não houve diferença entre os olhos direito e esquerdo. A tonometria de rebote e a ultrassonografia ocular em modo B são exames de rápida e fácil execução, sendo bem tolerados pelos animais. Este estudo contribuiu para a caracterização anatômica ocular e para o estabelecimento de valores médios da pressão intraocular e das medidas intraoculares, no entanto são necessárias outras pesquisas na área da fisiologia e histologia para melhor compreensão da função visual da espécie.
Published: 2020

25. PIERS: A Parallel Integrated Environment for Reliability Evaluation of Structures.

Author: C. Ferri, P. Contri, Paolo Salvaneschi, G. Meloni, G. Bottoni, and M. Cremonesi
Published: 1997
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26. 181P A randomized controlled trial on the efficacy of supervised exercise training in reducing IGF-1 levels in breast cancer survivors of the Movis’ cohort

Author: M. Bocconcelli, V. Natalucci, C. Ferri Marini, G. Annibalini, D. Sisti, F. Lucertini, L. Vallorani, M. De Santi, M.B.L. Rocchi, S. Barocci, M. Flori, G. Brandi, V. Catalano, A. Villarini, E. Barbieri, and R. Emili
Subjects: Oncology, Hematology
Published: 2022

27. Application of the 'immunization islands' model to improve quality, efficiency and safety of a COVID-19 mass vaccination site

Author: C, Signorelli, A, Odone, V, Gianfredi, M, Capraro, E, Kacerik, G, Chiecca, A, Scardoni, M, Minerva, R, Mantecca, P, Musarò, P, Brazzoli, P, Basteri, B, Bertini, F, Esposti, C, Ferri, V A, Alberti, and G, Gastaldi
Subjects: COVID-19 Vaccines, Italy, SARS-CoV-2, Facility Design and Construction, COVID-19, Humans, Community Health Centers, Models, Theoretical, Efficiency, Organizational, Mass Vaccination, Pandemics, Quality Improvement, Facilities and Services Utilization
Abstract: After SARS-CoV-2 vaccines development came at an unprecedented speed, ensuring safe and efficient mass immunization, vaccine delivery be-came the major public health mandate. Although mass-vaccination sites have been identified as essential to curb COVID-19, their organization and functioning is challenging. In this paper we present the planning, implementation and evalua-tion of a massive vaccination center in Lombardy - the largest Region in Italy and the most heavily hit by the pandemic. The massive hub of Novegro (Milan), managed by the Gruppo Ospedaliero San Donato, opened in April 2021. The Novegro mass-immunization model was developed building a la-yout based on the available scientific evidence, on comparative analysis with other existing models and on the experience of COVID-19 immunization delivery of Gruppo Ospedaliero San Donato. We propose a "vaccine islands" mass-immunization model, where 4 physicians and 2 nurses operate in each island, with up to 10 islands functioning at the same time, with the capacity of providing up to 6,000 vaccinations per day. During the first week of activity a total of 37,900 doses were administered (2,700/day), most of them with Pfizer vaccine (85.8%) and first doses (70.9%). The productivity was 10.5 vaccines/hour/vaccine station. Quality, efficiency and safety were boosted by ad-hoc personnel training, quality technical infrastructure and the presence of a shock room. Constant process monitoring allowed to identify and promptly tackle process pitfalls, including vaccine refusals (0.36%, below expectations) and post-vaccinations adverse reactions (0.4%). Our innovative "vaccine islands" mass-immunization model might be scaled-up or adapted to other settings. The Authors consider that sharing best practices in immunization delivery is fundamen-tal to achieve population health during health emergencies.
Published: 2021

28. Feeding a Financial Decision Support System with Textual Information.

Author: Frantz Vichot, Francis Wolinski, H.-C. Ferri, and D. Urbani
Published: 1999
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29. Real-life anti–vascular endothelial growth factor treatment for age-related macular degeneration and diabetic macular edema in an Italian tertiary referral hospital

Author: Maurizio Battaglia Parodi, Alessandro Arrigo, Francesco Bandello, Raffaele Sacchi, Gianluca Scanzi, Francesco Romano, C Ferri, Battaglia Parodi, M., Romano, F., Arrigo, A., Sacchi, R., Scanzi, G., Ferri, C., and Bandello, F.
Subjects: Male, Vascular Endothelial Growth Factor A, retina, medicine.medical_specialty, genetic structures, medicine.medical_treatment, Diabetic macular edema, Visual Acuity, Angiogenesis Inhibitors, Tertiary referral hospital, Macular Edema, Tertiary Care Centers, Macular Degeneration, 03 medical and health sciences, 0302 clinical medicine, Ranibizumab, Age related, Ophthalmology, medicine, Humans, Aged, Retrospective Studies, Anti vegf, Retina, Diabetic Retinopathy, business.industry, Age-related macular degeneration, Growth factor, General Medicine, Diabetic retinopathy, Middle Aged, Macular degeneration, medicine.disease, diabetic retinopathy, Treatment Outcome, medicine.anatomical_structure, Italy, Intravitreal Injections, 030221 ophthalmology & optometry, Female, diabetic macular edema, business, Tomography, Optical Coherence, 030217 neurology & neurosurgery, retina—medical therapies
Abstract: Purpose: To study the real-life outcomes of intravitreal anti–vascular endothelial growth factor treatment in patients affected by age-related macular degeneration and diabetic macular edema in an Italian tertiary referral hospital over a 2-year follow-up. Methods: Patients with confirmed diagnosis of age-related macular degeneration or diabetic macular edema and 2 years of follow-up were retrospectively analyzed. They underwent a loading dose of three monthly anti–vascular endothelial growth factor injections, with re-treatment performed following a “pro-re-nata” regimen. Best-corrected visual acuity and central retinal thickness were collected and statistically analyzed. Results: In total, 167 diabetic macular edema eyes and 108 age-related macular degeneration eyes were included. Mean age was 63.4 ± 11.8 years for diabetic macular edema and 75.6 ± 8.4 years for age-related macular degeneration. For diabetic macular edema patients, mean number of injections was 5.0 ± 1.7 at 1 year and 2.8 ± 1.8 at 2 years. Mean best-corrected visual acuity improved from 60 Early Treatment for Diabetic Retinopathy Study letters to 66.7 letters at 1 year, and to 70 letters at 2 years (p Conclusions: Our study described the 2-year real-life outcome of anti–vascular endothelial growth factor treatment of diabetic macular edema and age-related macular degeneration.
Published: 2019

30. POS0723 DIETARY HABITS AND THE IMPACT ON CLINICAL FEATURES IN PRIMARY SJOGREN’S SYNDROME

Author: A. Alunno, F. Carubbi, F. M. Mariani, M. Rossi, P. Sipari, D. Grassi, and C. Ferri
Subjects: Rheumatology, Immunology, Immunology and Allergy, General Biochemistry, Genetics and Molecular Biology
Abstract: BackgroundIn recent years, increasing evidence on the role of diet on chronic conditions, including cardiovascular diseases (CV) and rheumatic and musculoskeletal diseases (RMDs) has accrued. Most studies exploring the possible role of nutrients and dietary patterns on both the risk to develop RMDs in the general population and the natural history of the disease in patients with established RMDs pertain to rheumatoid arthritis. Data in patients with established primary Sjogren’s syndrome (pSS) is lacking.ObjectivesTo explore dietary habits and their relationship with metabolic and inflammatory features in a cohort of patients with established pSS.MethodsConsecutive patients with pSS were recruited and dietary habits over the previous 12 months were explored. Adherence to the Mediterranean Diet was assessed with the 14-item PREvencion con DIeta MEDiterranea’ (PREDIMED) tool and the 28-item Mediterranean Lifestyle (MEDLIFE) index. Adherence to the Dietary Approaches to Stop Hypertension (DASH) was estimated using a score based on 8 food items. Tea/herbal tea and coffee intake were also explored and clinical/serological records were retrospectively collected.ResultsWe enrolled 105 patients with pSS (95% females) with a mean age of 59 years. According to the PREDIMED score 32 (31%) patients had a good adherence to the Mediterranean Diet, 64 (61%) a medium adherence and only 9 (8%) a poor adherence. According to the DASH score, 74 (71%) patients had low adherence and 31 (29%) had high adherence. When dividing patients according to the extent of adherence to either of the dietary patterns and correlating the diet adherence scores to disease specific variables some associations emerged. The PREDIMED score was inversely correlated with disease activity, as measured by the EULAR Sjögren’s syndrome disease activity index (ESSDAI) (Spearman’s rho=-0.27, p= 0.009) and ClinESSDAI (Spearman’s rho=-0.26, p=0.01) revealing that a higher adherence to the Mediterranean Diet was associated with lower disease activity. With regard to the MEDLIFE, the total of blocks 1 and 2, that are related to Mediterranean foods and dietary habits, did not correlate with the total of block 3 (related to other healthy habits such as physical activity), meaning that the patients adhering the most to the Mediterranean Diet not necessarily had an overall healthy lifestyle. Adherence to DASH was not associated with disease activity. With regard to individual nutrients, fish consumption was associated with a lower prevalence of hypertension as observed in the general population. Higher intake of red meat was associated with higher values of self-reported pain (Spearman’s rho=-0.3; p=0.01) while high wholegrain intake was associated with a lower number of coexisting CV risk factors (OR=0.7; 95% CI=0.52-0.97; p=0.03).ConclusionAdherence to the Mediterranean Diet, with particular attention to high intake of fish and wholegrains and low intake of red meat, may be beneficial on various domains in pSS, such as the CV system and the inflammatory environment, and as such should be recommended to patients with this disease.Disclosure of InterestsNone declared
Published: 2022

31. POS1214 COVID-19 VACCINATION RATE AND SAFETY PROFILE IN PATIENTS AFFECTED BY MIXED CRYOGLOBULINEMIC VASCULITIS

Author: C. Vacchi, S. Testoni, M. Visentini, R. Zani, G. Lauletta, L. Gragnani, D. A. Filippini, C. Mazzaro, P. Fraticelli, L. Quartuccio, R. Padoan, L. Castelnovo, A. L. Zignego, C. Ferri, A. Hoxha, C. Salvarani, G. Monti, M. Galli, and M. Sebastiani
Subjects: Rheumatology, Immunology, Immunology and Allergy, General Biochemistry, Genetics and Molecular Biology
Abstract: BackgroundMixed cryoglobulinaemic vasculitis (MCV) is an immune-complex-mediated systemic vasculitis characterized by heterogeneous clinical manifestations mainly involving skin, kidney and peripheral nervous system.Despite reassuring safety data from EULAR Coronavirus Vaccine (COVAX) physician-reported registry, a significant proportion of patients with autoimmune diseases reported unwillingness to get vaccinated against SARS-CoV-2 infection in the preliminary results of the COVAD study, due to concerns about the lack of long-term safety data, and fear of associated side effects and disease flare.ObjectivesAims of this multicentre Italian study were to investigate the prevalence of vaccination against SARS-CoV-2 in Italian population of MCV patients, to explore the reason for the missed vaccination, and to investigate short and long-term side effects of the vaccine, including vasculitis flare.MethodsAll MCV patients referring to 12 Italian centres were investigated about vaccination and possible both short- (within 48 hours) and long-term (within 30 days) adverse events (AE), classified according to FDA Toxicity Grading Scale for preventive vaccine clinical trials, and possible disease flares. Patients with MCV related to lymphoproliferative disorders or connective tissue diseases were excluded from the study.The baseline variables were expressed as percentages or mean±standard deviation. The differences between continuous variables were analysed using the Mann–Whitney nonparametric test. The chi-squared test, or Fischer’s exact when appropriate, were used for categorical variables (absolute numbers and percentages) regarding baseline characteristics.ResultsA total of 416 patients, 69.2% females and 30.8% males, with a mean age of 70.4±11.7 years, were included in the study.Only 7.7% of patients were not vaccinated, mainly for fear of adverse events (50%) or for medical decision (18.8%). Corminaty was the vaccine most frequently used (80.5%). Interestingly, 6 patients (1.44%) were with a heterologous vaccination (usually AstraZeneca-Corminaty).Considering ongoing treatment, not vaccinated subjects were more frequently treated with chronic glucocorticoid therapy and/or Rituximab (p=0.049 and p=0.043 respectively).AE were recorded in 31.7% of cases, mainly mild and self-limiting (grade 1). More severe adverse events, such as flare of vasculitis, were observed in 5.3% of cases.AE were not associated with the kind of vaccine used and with the clinical manifestations of vasculitis. Patients with active MCV showed a lower frequency of short-term (within 48 hours) adverse events, but patients affected by peripheral neuropathies or skin vasculitis frequently showed a flare of their symptoms, recorded in 40% and 25% of cases, respectively. Finally, patients under glucocorticoid treatment were more prone to develop a vasculitis flare within a month after vaccination.ConclusionVaccination in MCV patients has been performed in a high percentage of patients showing a good safety. Other than patients’ fear, treatments with rituximab and glucocorticoids are the main reasons for delaying vaccination, and it should be considered by the physician before starting therapy. Vasculitis flares were observed in about 5% of cases, in line with that observed in other autoimmune diseases. Specific attention should be reserved to people with purpura or peripheral neuropathy, for the increased risk of exacerbation of their symptoms.References[1]Visentini M et al Flares of mixed cryoglobulinaemia vasculitis after vaccination against SARS-CoV-2 2021[2]Machado PM et al Safety of vaccination against SARS-CoV-2 in people with rheumatic and musculoskeletal diseases: results from the EULAR Coronavirus Vaccine COVAX physician-reported registry 2021[3]Sen P et al COVAD Study Group. COVID-19 vaccination in autoimmune disease COVAD survey protocol 2022[4]Scarpato S et al Italian Group for the Study of Cryoglobulinaemia GISC. Provisional recommendations for SARS-CoV-2 vaccination in patients with cryoglobulinaemic vasculitis 2021Disclosure of InterestsNone declared
Published: 2022

32. AB0524 RELATIONSHIP BETWEEN SERUM URIC ACID, CARDIOVASCULAR RISK AND INFLAMMATORY STATUS IN PRIMARY SJÖGREN’S SYNDROME

Author: A. Alunno, F. Carubbi, F. M. Mariani, M. Rossi, J. Santilli, and C. Ferri
Subjects: Rheumatology, Immunology, Immunology and Allergy, General Biochemistry, Genetics and Molecular Biology
Abstract: BackgroundAn unhealthy diet, with or without impaired renal urate excretion, is the most frequent cause of hyperuricemia. Despite its pivotal role in the pathogenesis of gout, the clinical relevance of serum uric acid (SUA) levels goes well beyond the simple association with gout and/or nephrolithiasis. Several studies pointed to hyperuricemia as cardiovascular (CV) risk factor in the general population therefore, the 2018 guidelines of the European Society of Cardiology and the European Society of Hypertension included the assessment of uricemia among the screening tests to be performed in hypertensive patients. Furthermore, in view of the association between hyperuricemia and mortality (both CV and all-cause) and CV events, it is conceivable that cardiovascular damage begins with much lower levels of uricemia. In this context, the first results of the URRAH (Uric Acid Right for Heart Health) study identified a uricemia threshold value of 4.7 mg/dL for all-cause mortality and 5.6 mg/dL for CV mortality1.ObjectivesSince patients with primary Sjögren’s syndrome (pSS) have a higher risk of CV events compared to the general population, we aimed to explore how uricemia correlates with other CV risk factors and previous CV events in patients with pSS and without gout.MethodsA cross sectional study was conducted recruiting consecutive patients with pSS without history of gout. SUA was measured upon recruitment alongside the assessment of disease activity (EULAR Sjögren’s syndrome disease activity index, ESSDAI and ClinESSDAI), patient reported symptoms (EULAR Sjögren’s syndrome patient reported symptoms, ESSPRI), CV risk factors including hypertension and diabetes among others, and previous CV events. Dietary habits were also explored with various food frequency questionnaires.ResultsOne hundred and three patients with pSS were enrolled. SUA levels ranged between 2.9 and 6.8 mg/dl and, according to the cut-off values of the URRAH study, 16 (16%) patients had SUA levels >4.7 mg/dL while 5 (5%) had SUA levels >5.6 mg/dL. Patients with SUA levels >4.7 mg/dL were more likely males (20% vs 3%) with a higher number of CV risk factors compared to patients with SUA levels 4.7 mg/dL compared to patients with SUA levels 4.7 mg/dL and a higher number of CV risk factors (OR 2.8; 95% CI=1.2-6.5; p=0.016).ConclusionAccumulating evidence highlights the emerging role of hyperuricemia as an independent CV risk factor, but no data are available in pSS patients. This is the first study demonstrating that SUA levels >4.7 mg/dL correlate with both a higher number of CV risk factors and a higher disease activity in pSS patients. Large interventional studies are needed to clarify the possible benefits of urate-lowering treatments in pSS patients.References[1]Virdis A et al. Identification of the Uric Acid Thresholds Predicting an Increased Total and Cardiovascular Mortality Over 20 Years. Hypertension 2020;75(2):302-308Disclosure of InterestsNone declared
Published: 2022

33. POS0992 CLINICAL AND IMAGING FEATURES IN SPONDYLOARTHRITIS PATIENTS WITH AND WITHOUT HLA-B27 AND HLA-B51: A VALIDATION COHORT

Author: F. Carubbi, A. Alunno, J. Cipollone, C. Martini, V. Moronti, and C. Ferri
Subjects: Rheumatology, Immunology, Immunology and Allergy, General Biochemistry, Genetics and Molecular Biology
Abstract: BackgroundDespite being commonly expressed in the general population, the human leucocyte antigen (HLA)-B27 allele strongly increases the susceptibility to develop spondyloarthritis (SpA). Likewise, the association between the HLA-B51 allele and the development of Behçet’s disease is well documented. In a previous pilot study, we identified similarities and differences in patients with axial or peripheral SpA according to the presence of HLA-B51 only, HLA-B27 only or neither of the two.ObjectivesTo investigate the clinical and imaging findings of SpA patients according to the absence or presence of HLA-B27 or HLA-B51 in an independent validation cohort.MethodsWe retrospectively analyzed patients with axial or peripheral SpA, according to the ASAS criteria, referring to our institution between 2020 and 2021. All patients had been tested for HLA-B alleles. Patients with HLA-B51 haplotype and fulfilling the criteria for Behçet’s disease were excluded.ResultsThe independent validation cohort included 185 patients and was comparable to the original cohort of 236 patients with regard to age, gender, age at diagnosis and symptom duration. In line with the findings in the original cohort we observed that aphtous lesions were more prevalent in patients with HLA-B51 (p< 0.001) while inflammatory bowel disease was more prevalent in the double negative group (p=0.0006). Unlike the original cohort, patients of the validation cohort did not show a different prevalence of inflammatory back pain (IBP) at disease onset or in the disease course based on the HLA status. A sub-analysis by gender demonstrated a comparable prevalence of IBP in males and females within the 3 groups. As novel finding, we observed that enthesitis and psoriasis were significantly more prevalent in the double negative group compared to the B27 and B51 groups (p=0.004) and their prevalence did not differ when comparing B27 and B51 groups. With regard to imaging in patients with axial manifestations, in the original cohort we observed that sacroiliitis, assessed by X-ray or magnetic resonance imaging (MRI), were more prevalent in double negative and HLA-B27 patients, compared to HLA-B51 patients and the latter showed a significant negative association with sacroiliitis on imaging (OR 0.342 CI 0.189-0.619 pConclusionOur findings underscore the clinical and radiological heterogeneity of patients with SpA and HLA-B51 alone or neither HLA-B27 nor HLA-B51 compared to those with HLA-B27 only and underline the need to explore further this area by means of registry data with large real-life cohorts.Disclosure of InterestsNone declared
Published: 2022

34. AB1181 THE BURDEN OF POST-SARS-COV2 VACCINE COMPLICATIONS AND NEWLY DIAGNOSED IMMUNE-MEDIATED INFLAMMATORY DISEASES

Author: F. Carubbi, A. Alunno, J. Santilli, J. Cipollone, C. Martini, V. Moronti, P. Sipari, and C. Ferri
Subjects: Rheumatology, Immunology, Immunology and Allergy, General Biochemistry, Genetics and Molecular Biology
Abstract: BackgroundLocal and systemic reactions have been observed after all vaccines for SARS-CoV-2 but in the majority of cases, symptoms are mild and self-limiting. However, evidence on more severe clinical scenarios, requiring admission to hospital or referral to outpatient clinics after the administration of SARS-CoV-2 vaccines has accrued. This also includes newly diagnosed diseases, such as cardiovascular and immune-mediated inflammatory diseases (IMID).ObjectivesWe aimed at quantifying the burden of post-vaccine hospital admissions/referrals and of newly diagnosed IMID.MethodsClinical records of patients referred to our Internal Medicine institution (both inpatients and outpatients) between February and June 2021 were retrospectively assessed. Subjects having received one or more doses of any of the EMA-approved SARS-CoV-2 vaccines within the previous 30 days were included. Subjects with a previous diagnosis of IMID were excluded.ResultsOur cohort included 99 patients, 45 females and 54 males, with a mean age of 64 years and a median of 3 comorbities (range 0-7). Eighty-eight patients (89%) required admission to the Internal Medicine ward while 11 were referred to the outpatient clinic. 68 (69%) of patients received the vaccine BNT162b2, 16 (16%) the ChAdOx1 nCoV-19, 9 (9%) the mRNA-1273 and 6 (6%) the Ad26.COV2.S. Twenty-seven (27%) subjects developed symptoms after the first vaccine dose with a mean latency of 2 days (median=0 indicating symptom onset on the day of the vaccine administration). Twenty-four (24%) subjects developed symptoms after the second dose with a mean latency of 4 days (median 1 day). All the other subjects did not develop symptoms within the week after the vaccine and were admitted for reasons apparently unrelated to vaccine administration. The number of presenting complaints ranged between 1 and 4 with 87% of subjects presenting with 1 or two coexisting complaints. Gastrointestinal manifestations were the most frequent being the presenting complaint in 31 (31%) of patients followed by severe fatigue/appetite loss in 19 (19%) of subjects, fever in 18 (18.2%) and neurological manifestation in 16 (16%) of subjects. A temporal and causal association with the SARS-CoV-2 vaccine was identified since all other known causes for these manifestations were ruled out. No in-hospital deaths were observed and 19 (19%) patients were diagnosed with a new onset IMID (Table 1). The clinical picture of these subjects was not significantly different from that of patients without a confirmed IMID and neither were demographic features. No association with the type of vaccine was observed.Table 1.Immune-mediated inflammatory diseases diagnosed after SARS-CoV2 vaccination (N=19)DiseaseNumber of patientsRheumatoid arthritis5Psoriatic arthritis2IgA vasculitis2Spondyloarthritis1Giant cell arteritis1Polymyalgia rheumatica1Gout1Primary biliary cholangitis1Antiphospholipid syndrome1Graves’ disease1Ulcerative colitis1Autoimmune thrombocytopenia1Leukocytoclastic vasculitis1ConclusionOur data show that post-vaccine newly diagnosed IMID may represent a challenge in clinical practice and it seems that no demographic or clinical feature is able to predict their onset. A multidisciplinary cooperation and registry data are needed in order to reliably estimate and define the impact of SARS-CoV-2 vaccinations on new onset IMID.Disclosure of InterestsNone declared
Published: 2022

35. POS1267 LONG-TERM SURVEY STUDY OF THE IMPACT OF COVID-19 ON SYSTEMIC AUTOIMMUNE DISEASES. LOW DEATH RATE DESPITE THE INCREASED PREVALENCE OF SYMPTOMATIC INFECTION. ROLE OF PRE-EXISTING INTERSTITIAL LUNG DISEASE AND ONGOING TREATMENTS

Author: C. Ferri, V. Raimondo, L. Gragnani, D. Giuggioli, L. Dagna, A. Tavoni, F. Ursini, M. L’andolina, F. Caso, P. Ruscitti, M. Caminiti, R. Foti, V. Riccieri, S. Guiducci, R. Pellegrini, E. Zanatta, G. Varcasia, D. Olivo, P. Gigliotti, G. Cuomo, G. Murdaca, R. Cecchetti, R. De Angelis, N. Romeo, F. Ingegnoli, F. Cozzi, V. Codullo, I. Cavazzana, M. Colaci, G. Abignano, M. De Santis, E. Lubrano, E. Fusaro, A. Spinella, F. Lumetti, G. De Luca, S. Bellando Randone, E. Visalli, Y. Dal Bosco, G. Amato, D. Giannini, S. Bilia, F. Masini, G. Pellegrino, E. Pigatto, E. Generali, G. Pagano Mariano, G. Pettiti, G. Zanframundo, R. Brittelli, V. Aiello, R. Caminiti, D. Scorpiniti, T. Ferrari, C. Campochiaro, V. Brusi, M. Fredi, L. Moschetti, F. Cacciapaglia, S. M. Ferrari, I. DI Cola, M. Vadacca, S. Lorusso, M. Monti, S. Lorini, S. R. Paparo, F. Ragusa, G. Elia, V. Mazzi, M. L. Aprile, M. Tasso, M. Miccoli, S. L. Bosello, S. D’angelo, A. Doria, F. Franceschini, R. Meliconi, M. Matucci-Cerinic, F. Iannone, R. Giacomelli, C. Salvarani, A. L. Zignego, P. Fallahi, and A. Antonelli
Subjects: Rheumatology, Immunology, Immunology and Allergy, General Biochemistry, Genetics and Molecular Biology
Abstract: BackgroundPatients with autoimmune systemic diseases (ASDs) can be counted among frail populations as regards the predisposition to COVID-19 due to the frequent visceral organ involvement and comorbidities, as well as the ongoing immunomodulating treatments.ObjectivesOur long-term multicenter telephone survey prospectively investigated the prevalence, prognostic factors, and outcomes of COVID-19 in Italian ASD patients during the first 3 pandemic waves.MethodsA large series of 3,918 ASD patients (815 M, 3103 F; mean age 59±12SD years) was consecutively recruited at the 36 referral centers of COVID-19 & ASD Italian Study Group. In particular, ASD series encompassed the following conditions: rheumatoid arthritis (n: 981), psoriatic arthritis (n: 471), ankylosing spondylitis (n: 159), systemic sclerosis (n: 1,738), systemic lupus (172), systemic vasculitis (n: 219), and a miscellany of other ASDs (n: 178). The development of COVID-19 was recorded by means of telephone survey using standardized symptom-assessment questionnaire (1).ResultsA significantly increased prevalence of COVID-19 (8.37% vs 6.49%; pInterestingly, a significantly higher COVID-19-related death rate was observed in systemic sclerosis patients compared to the Italian general population (6.29% vs 2.95%; p=0.018). Other adverse prognostic factors to develop COVID-19 were the patients’ older age, male gender, pre-existing ASD-related interstitial lung involvement, and chronic steroid treatment. Conversely, patients treated with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) showed a significantly lower prevalence of COVID-19 compared to those without (3.58% vs 46.99%; p=0.000), as well as the chronic administration of low dose aspirin in a subgroup of SSc patients (with 5.57% vs without 27.84%; p=0.000).ConclusionThe cumulative impact of COVID-19 on ASD patients after the first 3 pandemic waves revealed less severe than that observed during the first phase of pandemic (1), especially with regards to the death rate that was comparable to the Italian general population in spite of the increased prevalence of complicating COVID-19 in the same ASD series.Ongoing long-term treatments, mainly csDMARDs, might usefully contribute to generally positive outcomes of in this frail patients’ population.Of note, a significantly increased COVID-19-related mortality was recorded in only SSc patients’ subgroup, possibly favored by pre-existing lung fibrosis. Among different ASD, SSc deserves special attention, since it shares the main pathological alterations with COVID-19, namely the interstitial lung involvement and the endothelial injury responsible for diffuse microangiopathy.Besides SSc, the patients’ subgroups characterized by older age, chronic steroid treatment, pre-existing interstitial lung disease, and/or impaired COVID-19 vaccine response (1-3), may deserve well-designed prevention and management strategies.References[1]Ferri C, et al. Ann Rheum Dis. 2020 Oct 14 doi: 10.1136/annrheumdis-2020-219113.[2]Ferri C et al. J Autoimmun. 2021 Dec;125:102744. doi: 10.1016/j.jaut.2021.102744.[3]Visentini M et al. Ann Rheum Dis. 2021 Nov 24. doi: 10.1136/annrheumdis-2021-221248Disclosure of InterestsNone declared
Published: 2022

36. Integrating Health Technology Assessment and Multi-Criteria Decision Analysis in Optimizing Diabetic Macular Edema Management: Results from an Italian Multi-Regional Study

Author: Lucrezia Ferrario, Massimo Medaglia, P Tadini, Francesca Urban, Ugo Introini, Elisabetta Nuti, Giuseppe Scarpa, Teresa Zuppini, Giovanni Staurenghi, Francesco Bandello, Rita Francesca Tobaldi, Sabrina Beltramini, Fiorella Fusco, C Ferri, Michela Franzin, Roberto Tessari, Emanuela Foglia, Massimo Nicolò, and Davide Croce
Subjects: Multi criteria, business.industry, Process (engineering), Diabetic macular edema, medicine, Health technology, Operations management, General Medicine, Macular degeneration, medicine.disease, business, Multiple-criteria decision analysis
Abstract: Health Technology Assessment (HTA) is a widely implemented technical tool used to inform the decision-making process...
Published: 2020

37. Partial replacement of a total mixed ration with annual ryegrass herbage: effects on dairy cow dry matter intake and milk production

Author: Maurício Civiero, C. Ferris, and Henrique M. N. Ribeiro-Filho
Subjects: Intake, milk production, milk composition, Lolium multiflorum, Veterinary medicine, SF600-1100
Abstract: Studies with dairy cows receiving mixed ration and grazing annual pastures, which have low tiller density, are scarce. This study examined the effect of partial replacement of a total mixed ration (TMR) with annual temperate pasture. Treatments were ad libitum TMR (TMR100), 75% ad libitum TMR + ryegrass (Lolium multiflorum ‘Maximus’) (pTMR75), and 50% ad libitum TMR + ryegrass (pTMR50). Twelve multiparous Holstein and F1 Jersey × Holstein cows were divided into six groups (experimental units), taking account of milk production (26.6 ± 4.55 kg/day), days-in-milk (129 ± 50.8) and body weight (546 ± 30.6 kg). Treatments were compared using two 3 × 3 Latin square arangements, comprising three 21-day periods (measurements during final 5 days). Herbage DM intake increased from 4.8 kg/day with pTMR75 to 6.7 kg/day with pTMR50. Total DM intake decreased from 19.4 kg/day (TMR100), to 18.1 and 15.8 kg/day (pTMR75 and pTMR50, respectively). Milk production, energy corrected milk production (ECM), and milk fat content were similar between treatments, averaging 25.6, 28.4 kg/day and 44.6 g/kg, respectively. Ryegrass pastures were able to replace up to 50% of TMR offered to mid lactation dairy cows with no adverse effects on ECM production.
Published: 2023
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38. Systemic sclerosis Progression INvestiGation (SPRING) Italian registry: demographic and clinico-serological features of scleroderma spectrum

Author: C. Ferri, D. Giuggioli, S. Guiducci, F. Lumetti, G. Bajocchi, L. Magnani, V. Codullo, A. Ariani, F. Girelli, V. Riccieri, G. Pellegrino, S. Bosello, R. Foti, E. Visalli, G. Amato, A. Benenati, Giovanna Cuomo, F. Iannone, F. Cacciapaglia, R. De Angelis, F. Ingegnoli, R. Talotta, C. Campochiaro, L. Dagna, G. De Luca, S. Bellando-Randone, A. Spinella, G. Murdaca, N. Romeo, M. De Santis, E. Generali, S. Barsotti, A. Della Rossa, I. Cavazzana20, F. Dall’Ara20, M. G. Lazzaroni20, F. Cozzi22, A. Doria22, E. Pigatto22, E. Zanatta22, G. Ciano23, L. Beretta24, G. Abignano25, S. D’Angelo25, G. Mennillo25, G. Bagnato26, F. Calabrese27, M. Caminiti27, G. Pagano Mariano27, E. Battaglia28, E. Lubrano29, G. Zanframundo4, A. Iuliano30, F. Furini31, A. Zanetti32, G. Carrara32, F. Rumi32, C. A. Scirè31, M. Matucci-Cerinic2, on behalf of the Italian Society of Rheumatology (SIR), Ferri, C., Giuggioli, D., Guiducci, S., Lumetti, F., Bajocchi, G., Magnani, L., Codullo, V., Ariani, A., Girelli, F., Riccieri, V., Pellegrino, G., Bosello, S., Foti, R., Visalli, E., Amato, G., Benenati, A., Cuomo, Giovanna, Iannone, F., Cacciapaglia, F., De Angelis, R., Ingegnoli, F., Talotta, R., Campochiaro, C., Dagna, L., De Luca, G., Bellando-Randone, S., Spinella, A., Murdaca, G., Romeo, N., De Santis, M., Generali, E., Barsotti, S., Della Rossa, A., Cavazzana20, I., Dall’Ara20, F., Lazzaroni20, M. G., Cozzi22, F., Doria22, A., Pigatto22, E., Zanatta22, E., Ciano23, G., Beretta24, L., Abignano25, G., D’Angelo25, S., Mennillo25, G., Bagnato26, G., Calabrese27, F., Caminiti27, M., Pagano Mariano27, G., Battaglia28, E., Lubrano29, E., Zanframundo4, G., Iuliano30, A., Furini31, F., Zanetti32, A., Carrara32, G., Rumi32, F., Scirè31, C. A., Matucci-Cerinic2, M., and behalf of the Italian Society of Rheumatology (SIR), On
Subjects: systemic sclerosis, VEDOSS, Raynaud’s phenomenon
Abstract: Objective. Systemic sclerosis (SSc) is a severe multiple-organ disease charac- terised by unpredictable clinical course, inadequate response to treatment, and poor prognosis. National SSc registries may provide large and representative patients cohorts required for descriptive and prognostic studies. Therefore, the Italian Society of Rheumatology pro- moted the registry SPRING (Systemic sclerosis Progression INvestiGation). Methods. The SPRING is a multi- centre rheumatological cohort study encompassing the wide scleroder- ma spectrum, namely the primary Raynaud’s phenomenon (pRP), sus- pected secondary RP, Very Early Diag- nosis of Systemic Sclerosis (VEDOSS), and definite SSc. Here we describe the demographic and clinical characteris- tics of 2,028 Italian patients’ popula- tion at the initial phase of enrollment, mainly focusing on the cohort of 1,538 patients with definite SSc. Results. Definite SSc showed signifi- cantly higher prevalence of digital ul- cers, capillaroscopic ‘late’ pattern, oesophageal and cardio-pulmonary involvement compared to VEDOSS, as expected on the basis of the followed classification criteria. The in-depth analysis of definite SSc revealed that male gender, diffuse cu- taneous subset, and anti-Scl70 sero- positivity were significantly associated with increased prevalence of the most harmful disease manifestations. Similarly, patients with very short RP duration (≤1 year) at SSc diagnosis showed a statistically increased preva- lence of unfavorable clinico-serologi- cal features. Conclusion. Nationwide registries with suitable patients’ subsetting and follow-up studies since the prodromal phase of the disease may give us valu- able insights on the SSc natural history and main prognostic factors.
Published: 2020

39. Estudo clínico-oftálmico e citológico de felinos domésticos com conjuntivite e mantidos em adensamento populacional

Author: Jéssica Karla Alves da Silva, Joaquim Evêncio Neto, Fabrício Bezerra de Sá, Rinaldo C. Ferri, Priscilla Nogueira de Melo Omena, Elton Hugo Lima da Silva Souza, Giulliano Aires Anderlini, Sheylla Márcia Vasconcelos Barbosa, Edmilson Ferreira de Oliveira Filho, Manoel Adrião Gomes Filho, and Giovana Patrícia de Oliveira e Souza Anderlini
Subjects: superpopulação felina, lcsh:Veterinary medicine, oftalmologia felina, lcsh:SF600-1100, citologia ocular, General Medicine
Abstract: As conjuntivites se propagam facilmente em felinos, especialmente em abrigos e domicílios com elevado número de animais, diante dessa realidade objetivou-se com este estudo fazer uma avaliação oftálmica e citológica em felinos domésticos com conjuntivite e mantidos em adensamento populacional. Para tanto, foram estudados 18 animais da espécie felina, provenientes da rotina de atendimento oftálmico de dois abrigos e um domicilio. Dentre os sinais clínicos, houve predomínio de hiperemia conjuntival, quemose, e secreção mucopurulenta. Associados à conjuntivite, foram atendidos felinos apresentando úlcera dendítrica, simbléfaro e Phthisis bulbi. Na citologia, além das células epiteliais, houve maior frequência de neutrófilos, foram encontradas também inclusões citoplasmáticas morfologicamente compatíveis com Chlamydophila felis e bactérias. O estudo permitiu direcionar o diagnóstico com baixo custo e rapidez, sendo possível instituir terapia tópica e/ou sistêmica aos felinos com conjuntivite, além de oportunizar orientações sobre manejo com o objetivo de minimizar a disseminação das oftalmopatia nos animais mantidos em adensamento populacional.
Published: 2018

40. May Measurement Month 2017: an analysis of blood pressure screening results worldwide

Author: Thomas Beaney, Aletta E Schutte, Maciej Tomaszewski, Cono Ariti, Louise M Burrell, Rafael R Castillo, Fadi J Charchar, Albertino Damasceno, Ruan Kruger, Daniel T Lackland, Peter M Nilsson, Dorairaj Prabhakaran, Agustin J Ramirez, Markus P Schlaich, Jiguang Wang, Michael A Weber, Neil R Poulter, C Napiza-Granada, Ma. RC Sevilla, AA Atilano, DID Ona, A More, AP Jose, A Maheshwari, D Kondal, W Yu, W Li, S Xu, J Yu, H Zhang, B Widyantoro, Y Turana, TD Situmorang, Y Sofiatin, R Barack, H-J Lin, T-D Wang, W-J Chen, Y Sirenko, O Evstigneeva, E Negresku, ME Yousif, SA Medani, HM Beheiry, IA Ali, JM Zilberman, MJ Marin, PD Rodriguez, F Garcia-Vasquez, KE Kramoh, D Ekoua, P Lopez-Jaramillo, J Otero, G Sanchez, C Narvaez, JL Accini, R Hernandez-Hernandez, JA Octavio, I Morr, J Lopez-Rivera, D Ojji, A Arije, A Babatunte, KW Wahab, M Fernandes, SV Pereira, M Valentim, A Dzudie, S Kingue, DA Djomou Ngongang, EN Ogola, FA Barasa, B Gitura, F-T-N Malik, SR Choudhury, MA Al Mamun, VH Minh, NL Viet, S Cao Truong, C Ferri, G Parati, C Torlasco, C Borghi, FM Goma, C Syatalimi, PH Zelveian, E Barbosa, W Sebba Barroso, E Penaherrera, E Jarrin, A Yusufali, N Bazargani, B Tsinamdzgvrishvili, D Trapaidze, D Neupane, SR Mishra, J Jozwiak, J Malyszko, A Konradi, I Chazova, M Ishaq, F Memon, AM Heagerty, J Keitley, AJB Brady, JR Cockcroft, BJ McDonnell, F Lanas, Y-C Chia, H Ndhlovu, I Kiss, LM Ruilope, BF Ellenga Mbolla, AS Milhailidou, AJ Woodiwiss, S Perl, E Dolan, V Azevedo, L Garre, JG Boggia, VWY Lee, S Kowlessur, M Miglinas, D Sukackiene, RD Wainford, D Habonimana, T Masupe, J Ortellado, G Wuerzner, L Alcocer, G Burazeri, E Sanchez Delgado, D Lovic, CK Mondo, A Mostafa, SK Nadar, O Valdez Tiburcio, A Leiba, M Dorobantu, T De Backer, J Chifamba, G Stergiou, CR Nwokocha, S Sokolovic, AI Toure, KL Connell, NA Khan, D Burger, M De Carvalho Rodrigues, BK Kramer, RE Schmieder, T Unger, FS Wyss, NV Yameogo, H Beistline, JG Kenerson, B Alfonso, MH Olsen, M Soares, Beaney, T, Schutte, A, Tomaszewski, M, Ariti, C, Burrell, L, Castillo, R, Charchar, F, Damasceno, A, Kruger, R, Lackland, D, Nilsson, P, Prabhakaran, D, Ramirez, A, Schlaich, M, Wang, J, Weber, M, Poulter, N, Napiza-Granada, C, Sevilla, M, Atilano, A, Ona, D, More, A, Jose, A, Maheshwari, A, Kondal, D, Yu, W, Li, W, Xu, S, Yu, J, Zhang, H, Widyantoro, B, Turana, Y, Situmorang, T, Sofiatin, Y, Barack, R, Lin, H, Wang, T, Chen, W, Sirenko, Y, Evstigneeva, O, Negresku, E, Yousif, M, Medani, S, Beheiry, H, Ali, I, Zilberman, J, Marin, M, Rodriguez, P, Garcia-Vasquez, F, Kramoh, K, Ekoua, D, Lopez-Jaramillo, P, Otero, J, Sanchez, G, Narvaez, C, Accini, J, Hernandez-Hernandez, R, Octavio, J, Morr, I, Lopez-Rivera, J, Ojji, D, Arije, A, Babatunte, A, Wahab, K, REIS FERNANDES, M, Pereira, S, Valentim, M, Dzudie, A, Kingue, S, Djomou Ngongang, D, Ogola, E, Barasa, F, Gitura, B, Malik, F, Choudhury, S, Al Mamun, M, Minh, V, Viet, N, Cao Truong, S, Ferri, C, Parati, G, Torlasco, C, Borghi, C, Goma, F, Syatalimi, C, Zelveian, P, Barbosa, E, Sebba Barroso, W, Penaherrera, E, Jarrin, E, Yusufali, A, Bazargani, N, Tsinamdzgvrishvili, B, Trapaidze, D, Neupane, D, Mishra, S, Jozwiak, J, Malyszko, J, Konradi, A, Chazova, I, Ishaq, M, Memon, F, Heagerty, A, Keitley, J, Brady, A, Cockcroft, J, Mcdonnell, B, Lanas, F, Chia, Y, Ndhlovu, H, Kiss, I, Ruilope, L, Ellenga Mbolla, B, Milhailidou, A, Woodiwiss, A, Perl, S, Dolan, E, Azevedo, V, Garre, L, Boggia, J, Lee, V, Kowlessur, S, Miglinas, M, Sukackiene, D, Wainford, R, Habonimana, D, Masupe, T, Ortellado, J, Wuerzner, G, Alcocer, L, Burazeri, G, Sanchez Delgado, E, Lovic, D, Mondo, C, Mostafa, A, Nadar, S, Valdez Tiburcio, O, Leiba, A, Dorobantu, M, De Backer, T, Chifamba, J, Stergiou, G, Nwokocha, C, Sokolovic, S, Toure, A, Connell, K, Khan, N, Burger, D, De Carvalho Rodrigues, M, Kramer, B, Schmieder, R, Unger, T, Wyss, F, Yameogo, N, Beistline, H, Kenerson, J, Alfonso, B, Olsen, M, Soares, M, and Thomas Beaney, Aletta E Schutte, Maciej Tomaszewski, Cono Ariti, Louise M Burrell, Rafael R Castillo, Fadi J Charchar, Albertino Damasceno, Ruan Kruger, Daniel T Lackland, Peter M Nilsson, Dorairaj Prabhakaran, Agustin J Ramirez, Markus P Schlaich, Jiguang Wang, Michael A Weber, Neil R Poulter, MMM Investigators, Claudio Borghi
Subjects: Adult, Male, AWARENESS, medicine.medical_specialty, Lydia Becker Institute, Adolescent, Cross-sectional study, Population, Blood Pressure, 030204 cardiovascular system & hematology, Global Health, Young Adult, 03 medical and health sciences, 0302 clinical medicine, ResearchInstitutes_Networks_Beacons/lydia_becker_institute_of_immunology_and_inflammation, Diabetes mellitus, MANAGEMENT, MMM Investigators, Humans, Mass Screening, Medicine, 030212 general & internal medicine, Imputation (statistics), Young adult, education, Volunteer, Mass screening, Public, Environmental & Occupational Health, Aged, Aged, 80 and over, prescription, education.field_of_study, Science & Technology, HYPERTENSION, business.industry, lcsh:Public aspects of medicine, Medicine (all), lcsh:RA1-1270, General Medicine, Middle Aged, medicine.disease, PREVALENCE, Anniversaries and Special Events, Cross-Sectional Studies, Blood pressure, Emergency medicine, Female, business, Life Sciences & Biomedicine
Abstract: Summary Background Increased blood pressure is the biggest contributor to the global burden of disease and mortality. Data suggest that less than half of the population with hypertension is aware of it. May Measurement Month was initiated to raise awareness of the importance of blood pressure and as a pragmatic interim solution to the shortfall in screening programmes. Methods This cross-sectional survey included volunteer adults (≥18 years) who ideally had not had their blood pressures measured in the past year. Each participant had their blood pressure measured three times and received a a questionnaire about demographic, lifestyle, and environmental factors. The primary objective was to raise awareness of blood pressure, measured by number of countries involved, number of people screened, and number of people who have untreated or inadequately treated hypertension (defined as systolic blood pressure ≥140 mm Hg or diastolic blood pressure ≥90 mm Hg, or both, or on the basis of receiving antihypertensive medication). Multiple imputation was used to estimate the mean of the second and third blood pressure readings if these were not recorded. Measures of association were analysed using linear mixed models. Findings Data were collected from 1 201 570 individuals in 80 countries. After imputation, of the 1 128 635 individuals for whom a mean of the second and third readings was available, 393 924 (34·9%) individuals had hypertension. 153 905 (17·3%) of 888 616 individuals who were not receiving antihypertensive treatment were hypertensive, and 105 456 (46·3%) of the 227 721 individuals receiving treatment did not have controlled blood pressure. Significant differences in adjusted blood pressures and hypertension prevalence were apparent between regions. Adjusted blood pressure was higher in association with antihypertensive medication, diabetes, cerebrovascular disease, smoking, and alcohol consumption. Blood pressure was higher when measured on the right arm than on the left arm, and blood pressure was highest on Saturdays. Interpretation Inexpensive global screening of blood pressure is achievable using volunteers and convenience sampling. Pending the set-up of systematic surveillance systems worldwide, MMM will be repeated annually to raise awareness of blood pressure. Funding International Society of Hypertension, Centers for Disease Control and Prevention, Servier Pharmaceutical Co.
Published: 2018

41. Influence of the concentrate inclusion level in a grass silage–based diet on hepatic transcriptomic profiles in Holstein-Friesian dairy cows in early lactation

Author: Z. Cheng, M.W. Little, C. Ferris, H. Takeda, K.L. Ingvartsen, M.A. Crowe, and D.C. Wathes
Subjects: hepatic transcriptome, cholesterol biosynthesis, fibrosis, PPAR, inflammation, Dairy processing. Dairy products, SF250.5-275, Dairying, SF221-250
Abstract: ABSTRACT: Excessive negative energy balance in early lactation is linked to an increased disease risk but may be mitigated by appropriate nutrition. The liver plays central roles in both metabolism and immunity. Hepatic transcriptomic profiles were compared between 3 dietary groups in each of 40 multiparous and 18 primiparous Holstein-Friesian cows offered isonitrogenous grass silage-based diets with different proportions of concentrates: (1) low concentrate (LC, 30% concentrate + 70% grass silage); (2) medium concentrate (MC, 50% concentrate + 50% grass silage), or (3) high concentrate (HC, 70% concentrate + 30% grass silage). Liver biopsies were taken from all cows at around 14 d in milk for RNA sequencing, and blood metabolites were measured. The sequencing data were analyzed separately for primiparous and multiparous cows using CLC Genomics Workbench V21 (Qiagen Digital Insights), focusing on comparisons between HC and LC groups. More differentially expressed genes (DEG) were seen between the primiparous cows receiving HC versus LC diets than for multiparous cows (597 vs. 497), with only 73 in common, indicating differential dietary responses. Multiparous cows receiving the HC diet had significantly higher circulating glucose and insulin-like growth factor-1 and lower urea than those receiving the LC diet. In response to HC, only the multiparous cows produced more milk. In these animals, bioinformatic analysis indicated expression changes in genes regulating fatty acid metabolism and biosynthesis (e.g., ACACA, ELOVL6, FADS2), increased cholesterol biosynthesis (e.g., CYP7A1, FDPS, HMGCR), downregulation in hepatic AA synthesis (e.g., GPT, GCLC, PSPH, SHMT2), and decreased expression of acute phase proteins (e.g., HP, LBP, SAA2). The primiparous cows on the HC diet also downregulated genes controlling AA metabolism and synthesis (e.g., CTH, GCLC, GOT1, ODC1, SHMT2) but showed higher expression of genes indicative of inflammation (e.g., CCDC80, IL1B, S100A8) and fibrosis (e.g., LOX, LUM, PLOD2). This potentially adverse response to a HC diet in physically immature animals warrants further investigation.
Published: 2023
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42. Prevention, monitoring and treatment of cardiovascular adverse events in myeloma patients receiving carfilzomib A consensus paper by the European Myeloma Network and the Italian Society of Arterial Hypertension

Author: S. Bringhen, A. Milan, M. D'Agostino, C. Ferri, R. Wäsch, F. Gay, A. Larocca, M. Offidani, S. Zweegman, E. Terpos, H. Goldschmidt, M. Cavo, H. Ludwig, C. Driessen, H. W. Auner, J. Caers, M. Gramatzki, M. A. Dimopoulos, M. Boccadoro, H. Einsele, P. Sonneveld, M. Engelhardt, Hematology, CCA - Cancer Treatment and quality of life, Anatomy and neurosciences, Bringhen, S, Milan, A, D'Agostino, M, Ferri, C, Wäsch, R, Gay, F, Larocca, A, Offidani, M, Zweegman, S, Terpos, E, Goldschmidt, H, Cavo, M, Ludwig, H, Driessen, C, Auner, H W, Caers, J, Gramatzki, M, Dimopoulos, M A, Boccadoro, M, Einsele, H, Sonneveld, P, and Engelhardt, M
Subjects: 0301 basic medicine, adverse event, 030204 cardiovascular system & hematology, RECOMMENDATIONS, chemistry.chemical_compound, 0302 clinical medicine, Prospective cohort study, AMERICAN SOCIETY, Multiple myeloma, LENALIDOMIDE, Hematology, carfilzomib, ASSOCIATION, DEXAMETHASONE, multiple myeloma, Cardiovascular Diseases, ECHOCARDIOGRAPHY, Life Sciences & Biomedicine, Oligopeptides, medicine.drug, CANCER-THERAPY, medicine.medical_specialty, cardiovascular toxicity, adverse events, blood pressure monitoring, clinical assessment, 03 medical and health sciences, Medicine, General & Internal, General & Internal Medicine, Internal medicine, Internal Medicine, medicine, Humans, Adverse effect, Monitoring, Physiologic, Lenalidomide, Science & Technology, CARDIOMYOPATHY, business.industry, Decision Trees, 1103 Clinical Sciences, medicine.disease, Carfilzomib, DYSFUNCTION, 030104 developmental biology, Blood pressure, Cardiovascular System & Hematology, chemistry, Heart failure, business, CARDIOTOXICITY ROLE
Abstract: The novel proteasome inhibitor carfilzomib alone or in combination with other agents is already one of the standard therapies in relapsed and/or refractory multiple myeloma (MM) patients and produces impressive response rates in newly diagnosed MM as well. However, carfilzomib-related cardiovascular adverse events (CVAEs) - including hypertension (all grades: 12.2%; grade ≥3: 4.3%), heart failure (all grades: 4.1%; grade ≥3: 2.5%) and ischemic heart disease (all grades: 1.8%; grade ≥3: 0.8%) - may lead to treatment suspensions. At present, there are neither prospective studies nor expert consensus on the prevention, monitoring and treatment of CVAEs in myeloma patients treated with carfilzomib. An expert panel of the European Myeloma Network in collaboration with the Italian Society of Arterial Hypertension and with the endorsement of the European Hematology Association aimed to provide recommendations to support health professionals in selecting the best management strategies for patients, considering the impact on outcome, the risk-benefit ratio of diagnostic and therapeutic tools and thereby to achieve myeloma response with novel combination approaches, while preventing CVAEs. Patients scheduled to receive carfilzomib need a careful cardiovascular evaluation before treatment and an accurate follow-up during treatment. A detailed clinical assessment before starting carfilzomib treatment is essential to identify patients at risk for CVAEs, and accurate monitoring of blood pressure and of early signs and symptoms suggestive of cardiac dysfunction remains pivotal to safely administer carfilzomib without treatment interruptions or dose reductions. This article is protected by copyright. All rights reserved.
Published: 2019

43. Single nucleotide polymorphism in PTEN-Long gene: a risk factor in chronic myeloid leukemia

Author: Irene Larripa, C. Ferri, Natalia Weich, Ariela Freya Fundia, M.R. Bengió, Leandro German Gutierrez, P. Zapata, and C. D. De Brasi
Subjects: Adult, Male, 0301 basic medicine, CIENCIAS MÉDICAS Y DE LA SALUD, Population, Biotecnología relacionada con la Salud, Fusion Proteins, bcr-abl, Single-nucleotide polymorphism, Biology, Polymorphism, Single Nucleotide, PTEN-LONG, Biotecnología de la Salud, 03 medical and health sciences, Exon, 0302 clinical medicine, Gene Frequency, Risk Factors, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, hemic and lymphatic diseases, Genetics, Humans, Protein Isoforms, PTEN, Tensin, Genetic Predisposition to Disease, Allele, education, Gene, Alleles, Aged, Aged, 80 and over, education.field_of_study, CHRONIC MYELOID LEUKEMIA, Age Factors, PTEN Phosphohydrolase, Myeloid leukemia, General Medicine, Middle Aged, BCR-ABL1, POLYMORPHISM, 030104 developmental biology, Case-Control Studies, 030220 oncology & carcinogenesis, Mutation, Cancer research, biology.protein, Female, Signal Transduction
Abstract: Fil: Ferri, Cristian Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico (Nordeste). Instituto de Biotecnología Misiones. Laboratorio de Biotecnología Molecular; Argentina. Fil: Ferri, Cristian Alberto. Universidad Nacional de Misiones. Facultad de Ciencias Exactas Químicas y Naturales. Instituto Biotecnología Misiones. Laboratorio de Biotecnología Molecular; Argentina. Fil: Weich, Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Laboratorio de Genética Hematológica; Argentina. Fil: Weich, Natalia. Academia Nacional de Medicina (Buenos Aires). Instituto de Medicina Experimental. Laboratorio de Genética Hematológica; Argentina. Fil: Weich, Natalia. Universidad de Miami. Facultad de Medicina Leonard M. Miller; Estados Unidos. Fil: Gutiérrez, L. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Laboratorio de Genética Hematológica; Argentina. Fil: Gutiérrez, L. Academia Nacional de Medicina (Buenos Aires). Instituto de Medicina Experimental. Laboratorio de Genética Hematológica; Argentina. Fil: De Brasi, Carlos Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Laboratorio de Genética Hematológica; Argentina. Fil: De Brasi, Carlos Daniel. Academia Nacional de Medicina (Buenos Aires). Instituto de Medicina Experimental. Laboratorio de Genética Hematológica; Argentina. Fil: Bengió, M. R. Academia Nacional de Medicina (Buenos Aires). Instituto de Investigaciones Hematológicas "Mariano R. Castex". Departamento de Hemato-oncología; Argentina. Fil: Zapata, Pedro Darío. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico (Nordeste). Instituto de Biotecnología Misiones. Laboratorio de Biotecnología Molecular; Argentina. Fil: Zapata, Pedro Darío. Universidad Nacional de Misiones. Facultad de Ciencias Exactas Químicas y Naturales. Instituto Biotecnología Misiones. Laboratorio de Biotecnología Molecular; Argentina. Fil: Fundia, Ariela Freya. Academia Nacional de Medicina (Buenos Aires). Instituto de Investigaciones Hematológicas "Mariano R. Castex". Departamento de Hemato-oncología; Argentina. Fil: Larripa, Irene Beatriz. Academia Nacional de Medicina (Buenos Aires). Instituto de Investigaciones Hematológicas "Mariano R. Castex". Departamento de Hemato-oncología; Argentina. The BCR-ABL1 oncogene is associated with chronic myeloid leukemia (CML) pathogenesis, but the molecular mechanisms that initiate leukemogenesis are still unclear. Cancer pathogenesis has been associated with genetic alterations that may lead to inactivation of tumor suppressor genes. Phosphatase and tensin homolog (PTEN) is frequently deleted or inactivated in various tumors. A recently discovered variant of PTEN, PTEN-Long (PTEN-L), results from an alternative translation initiation site located upstream of the canonic AUG and generates a protein of 576 amino acids instead the expected protein of 403 amino acids. A 16 bp perfect palindromic motif centered on the PTEN-L CUG 513 start codon is required for translation initiation. A single nucleotide polymorphism (SNP) of PTEN-L gene rs12573787 is located on the first exon respect to the CUG initiation site. In this case-control study we evaluated the association of genetic variants in PTEN-L with CML risk and therapy response in the Argentine population. The allele A of SNP rs12573787 was found to be associated with CML risk OR (95% CI) 1.71 (1.11–2.63) p = 0.016, which resulted consistent by multivariate analysis adjusted by gender and age. According to previous evidence that CML is more frequent in males, we found that the genetic risk of CML was confined to this gender. Unexpectedly, we also found this association confined to CML patients older than 45 years old. To our knowledge, this is the first time that PTEN-L rs1257378 was studied in CML suggesting that the variant A allele is a risk factor for CML development but, no association with the failure to TKIs treatment was found.
Published: 2019

44. RELATIONSHIP BETWEEN DIURETIC RELATED HYPERURICEMIA AND CARDIOVASCULAR EVENTS: DATA FROM THE URRAH (URIC ACID RIGHT FOR HEART HEALTH) STUDY

Author: Alessandro Maloberti, M. Bombelli, R. Facchetti, A. Virdis, E. Casiglia, V. Tikhonoff, C.m. Barbagallo, M. Cirillo, G. Desideri, C. Ferri, F. Galletti, G. Iaccarino, F. Mallamaci, S. Masi, A. Mazza, M.l. Muiesan, M. Salvetti, P. Palatini, R. Pontremoli, P. Verdecchia, M. Volpe, G. Grassi, C. Giannattasio, and C. Borghi
Subjects: Physiology, Internal Medicine, Cardiology and Cardiovascular Medicine
Published: 2021

45. Natural polymorphisms in the resistance associated sites of HCV-G1 NS5B domain and correlation with geographic origin of HCV isolates

Author: Alessandro Olgiati, Caterina Uberti-Foppa, Sabrina Bagaglio, C Ferri, Emanuela Messina, Hamid Hasson, Giulia Morsica, Bagaglio, Sabrina, Uberti-Foppa, Caterina, Olgiati, Alessandro, Messina, Emanuela, Hasson, Hamid, Ferri, Camilla, and Morsica, Giulia
Subjects: United State, 0301 basic medicine, Asia, Genotype, 030106 microbiology, Mutation, Missense, NS5b polymerase inhibitor, Viral Nonstructural Proteins, Biology, Resistance associated substitutions (RASs), lcsh:Infectious and parasitic diseases, Correlation, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Polymorphism (computer science), Virology, Drug Resistance, Viral, Prevalence, Humans, NS5b polymerase inhibitors, lcsh:RC109-216, In patient, NS5B, Anti-HCV direct acting antivirals (DAAs), Molecular Epidemiology, Polymorphism, Genetic, Viral Nonstructural Protein, Hepatitis C, United States, Europe, VIROLOGIC FAILURE, Geographic distribution, Phylogeography, Infectious Diseases, chemistry, HCV genotype, Geographic origin, 030211 gastroenterology & hepatology, Human
Abstract: Background We evaluated the frequency of naturally occurring resistance associated substitutions (RASs) and their characteristic of polymorphic or non-polymorphic amino acid change to direct acting antivirals (DAAs) in NS5b HCV subtypes 1a and 1b according to different geographic origin of isolates. Methods Using a public database we retrieved 738 worldwide NS5b sequences (for which was available the geographic origin) from HCV genotype (G)1 infected patients naive to DAAs. NS5b sequences clustering with G1a were more conserved in regard of RASs than G1b isolates, (14% vs 57% RASs, P
Published: 2018

46. PSS9 DRUG UTILIZATION AND COSTS OF INTRAVITREAL INJECTED ANTIVEGFS IN ITALY

Author: Delia Colombo, Ugo Introini, M Nica, P Tadini, M Albrecht, Francesco Bandello, and C Ferri
Subjects: Drug Utilization, medicine.medical_specialty, business.industry, Health Policy, Emergency medicine, Public Health, Environmental and Occupational Health, medicine, business
Published: 2019

47. Azimuthal anisotropy of charged particles with transverse momentum up to 100 GeV/c in PbPb collisions at sNN=5.02 TeV

Author: Sirunyan, A.M. Tumasyan, A. Adam, W. Asilar, E. Bergauer, T. Brandstetter, J. Brondolin, E. Dragicevic, M. Erö, J. Flechl, M. Friedl, M. Frühwirth, R. Ghete, V.M. Hartl, C. Hörmann, N. Hrubec, J. Jeitler, M. König, A. Krätschmer, I. Liko, D. Matsushita, T. Mikulec, I. Rabady, D. Rad, N. Rahbaran, B. Rohringer, H. Schieck, J. Strauss, J. Waltenberger, W. Wulz, C.-E. Dvornikov, O. Makarenko, V. Mossolov, V. Suarez Gonzalez, J. Zykunov, V. Shumeiko, N. Alderweireldt, S. De Wolf, E.A. Janssen, X. Lauwers, J. Van De Klundert, M. Van Haevermaet, H. Van Mechelen, P. Van Remortel, N. Van Spilbeeck, A. Abu Zeid, S. Blekman, F. D'Hondt, J. Daci, N. De Bruyn, I. Deroover, K. Lowette, S. Moortgat, S. Moreels, L. Olbrechts, A. Python, Q. Skovpen, K. Tavernier, S. Van Doninck, W. Van Mulders, P. Van Parijs, I. Brun, H. Clerbaux, B. De Lentdecker, G. Delannoy, H. Fasanella, G. Favart, L. Goldouzian, R. Grebenyuk, A. Karapostoli, G. Lenzi, T. Léonard, A. Luetic, J. Maerschalk, T. Marinov, A. Randle-conde, A. Seva, T. Vander Velde, C. Vanlaer, P. Vannerom, D. Yonamine, R. Zenoni, F. Zhang, F. Cimmino, A. Cornelis, T. Dobur, D. Fagot, A. Gul, M. Khvastunov, I. Poyraz, D. Salva, S. Schöfbeck, R. Tytgat, M. Van Driessche, W. Yazgan, E. Zaganidis, N. Bakhshiansohi, H. Beluffi, C. Bondu, O. Brochet, S. Bruno, G. Caudron, A. De Visscher, S. Delaere, C. Delcourt, M. Francois, B. Giammanco, A. Jafari, A. Komm, M. Krintiras, G. Lemaitre, V. Magitteri, A. Mertens, A. Musich, M. Piotrzkowski, K. Quertenmont, L. Selvaggi, M. Vidal Marono, M. Wertz, S. Beliy, N. Aldá Júnior, W.L. Alves, F.L. Alves, G.A. Brito, L. Hensel, C. Moraes, A. Pol, M.E. Rebello Teles, P. Belchior Batista Das Chagas, E. Carvalho, W. Chinellato, J. Custódio, A. Da Costa, E.M. Da Silveira, G.G. De Jesus Damiao, D. De Oliveira Martins, C. Fonseca De Souza, S. Huertas Guativa, L.M. Malbouisson, H. Matos Figueiredo, D. Mora Herrera, C. Mundim, L. Nogima, H. Prado Da Silva, W.L. Santoro, A. Sznajder, A. Tonelli Manganote, E.J. Torres Da Silva De Araujo, F. Vilela Pereira, A. Ahuja, S. Bernardes, C.A. Dogra, S. Fernandez Perez Tomei, T.R. Gregores, E.M. Mercadante, P.G. Moon, C.S. Novaes, S.F. Padula, S.S. Romero Abad, D. Ruiz Vargas, J.C. Aleksandrov, A. Hadjiiska, R. Iaydjiev, P. Rodozov, M. Stoykova, S. Sultanov, G. Vutova, M. Dimitrov, A. Glushkov, I. Litov, L. Pavlov, B. Petkov, P. Fang, W. Ahmad, M. Bian, J.G. Chen, G.M. Chen, H.S. Chen, M. Chen, Y. Cheng, T. Jiang, C.H. Leggat, D. Liu, Z. Romeo, F. Ruan, M. Shaheen, S.M. Spiezia, A. Tao, J. Wang, C. Wang, Z. Zhang, H. Zhao, J. Ban, Y. Chen, G. Li, Q. Liu, S. Mao, Y. Qian, S.J. Wang, D. Xu, Z. Avila, C. Cabrera, A. Chaparro Sierra, L.F. Florez, C. Gomez, J.P. González Hernández, C.F. Ruiz Alvarez, J.D. Sanabria, J.C. Godinovic, N. Lelas, D. Puljak, I. Ribeiro Cipriano, P.M. Sculac, T. Antunovic, Z. Kovac, M. Brigljevic, V. Ferencek, D. Kadija, K. Mesic, B. Susa, T. Ather, M.W. Attikis, A. Mavromanolakis, G. Mousa, J. Nicolaou, C. Ptochos, F. Razis, P.A. Rykaczewski, H. Finger, M. Finger, M., Jr. Carrera Jarrin, E. Ellithi Kamel, A. Mahmoud, M.A. Radi, A. Kadastik, M. Perrini, L. Raidal, M. Tiko, A. Veelken, C. Eerola, P. Pekkanen, J. Voutilainen, M. Härkönen, J. Järvinen, T. Karimäki, V. Kinnunen, R. Lampén, T. Lassila-Perini, K. Lehti, S. Lindén, T. Luukka, P. Tuominiemi, J. Tuovinen, E. Wendland, L. Talvitie, J. Tuuva, T. Besancon, M. Couderc, F. Dejardin, M. Denegri, D. Fabbro, B. Faure, J.L. Favaro, C. Ferri, F. Ganjour, S. Ghosh, S. Givernaud, A. Gras, P. Hamel de Monchenault, G. Jarry, P. Kucher, I. Locci, E. Machet, M. Malcles, J. Rander, J. Rosowsky, A. Titov, M. Abdulsalam, A. Antropov, I. Baffioni, S. Beaudette, F. Busson, P. Cadamuro, L. Chapon, E. Charlot, C. Davignon, O. Granier de Cassagnac, R. Jo, M. Lisniak, S. Miné, P. Nguyen, M. Ochando, C. Ortona, G. Paganini, P. Pigard, P. Regnard, S. Salerno, R. Sirois, Y. Stahl Leiton, A.G. Strebler, T. Yilmaz, Y. Zabi, A. Zghiche, A. Agram, J.-L. Andrea, J. Aubin, A. Bloch, D. Brom, J.-M. Buttignol, M. Chabert, E.C. Chanon, N. Collard, C. Conte, E. Coubez, X. Fontaine, J.-C. Gelé, D. Goerlach, U. Le Bihan, A.-C. Van Hove, P. Gadrat, S. Beauceron, S. Bernet, C. Boudoul, G. Carrillo Montoya, C.A. Chierici, R. Contardo, D. Courbon, B. Depasse, P. El Mamouni, H. Fay, J. Gascon, S. Gouzevitch, M. Grenier, G. Ille, B. Lagarde, F. Laktineh, I.B. Lethuillier, M. Mirabito, L. Pequegnot, A.L. Perries, S. Popov, A. Sabes, D. Sordini, V. Vander Donckt, M. Verdier, P. Viret, S. Khvedelidze, A. Bagaturia, I. Autermann, C. Beranek, S. Feld, L. Kiesel, M.K. Klein, K. Lipinski, M. Preuten, M. Schomakers, C. Schulz, J. Verlage, T. Albert, A. Brodski, M. Dietz-Laursonn, E. Duchardt, D. Endres, M. Erdmann, M. Erdweg, S. Esch, T. Fischer, R. Güth, A. Hamer, M. Hebbeker, T. Heidemann, C. Hoepfner, K. Knutzen, S. Merschmeyer, M. Meyer, A. Millet, P. Mukherjee, S. Olschewski, M. Padeken, K. Pook, T. Radziej, M. Reithler, H. Rieger, M. Scheuch, F. Sonnenschein, L. Teyssier, D. Thüer, S. Cherepanov, V. Flügge, G. Kargoll, B. Kress, T. Künsken, A. Lingemann, J. Müller, T. Nehrkorn, A. Nowack, A. Pistone, C. Pooth, O. Stahl, A. Aldaya Martin, M. Arndt, T. Asawatangtrakuldee, C. Beernaert, K. Behnke, O. Behrens, U. Bin Anuar, A.A. Borras, K. Campbell, A. Connor, P. Contreras-Campana, C. Costanza, F. Diez Pardos, C. Dolinska, G. Eckerlin, G. Eckstein, D. Eichhorn, T. Eren, E. Gallo, E. Garay Garcia, J. Geiser, A. Gizhko, A. Grados Luyando, J.M. Grohsjean, A. Gunnellini, P. Harb, A. Hauk, J. Hempel, M. Jung, H. Kalogeropoulos, A. Karacheban, O. Kasemann, M. Keaveney, J. Kleinwort, C. Korol, I. Krücker, D. Lange, W. Lelek, A. Lenz, T. Leonard, J. Lipka, K. Lobanov, A. Lohmann, W. Mankel, R. Melzer-Pellmann, I.-A. Meyer, A.B. Mittag, G. Mnich, J. Mussgiller, A. Pitzl, D. Placakyte, R. Raspereza, A. Roland, B. Sahin, M.Ö. Saxena, P. Schoerner-Sadenius, T. Spannagel, S. Stefaniuk, N. Van Onsem, G.P. Walsh, R. Wissing, C. Blobel, V. Centis Vignali, M. Draeger, A.R. Dreyer, T. Garutti, E. Gonzalez, D. Haller, J. Hoffmann, M. Junkes, A. Klanner, R. Kogler, R. Kovalchuk, N. Lapsien, T. Marchesini, I. Marconi, D. Meyer, M. Niedziela, M. Nowatschin, D. Pantaleo, F. Peiffer, T. Perieanu, A. Scharf, C. Schleper, P. Schmidt, A. Schumann, S. Schwandt, J. Stadie, H. Steinbrück, G. Stober, F.M. Stöver, M. Tholen, H. Troendle, D. Usai, E. Vanelderen, L. Vanhoefer, A. Vormwald, B. Akbiyik, M. Barth, C. Baur, S. Baus, C. Berger, J. Butz, E. Caspart, R. Chwalek, T. Colombo, F. De Boer, W. Dierlamm, A. Fink, S. Freund, B. Friese, R. Giffels, M. Gilbert, A. Goldenzweig, P. Haitz, D. Hartmann, F. Heindl, S.M. Husemann, U. Katkov, I. Kudella, S. Mildner, H. Mozer, M.U. Müller, T. Plagge, M. Quast, G. Rabbertz, K. Röcker, S. Roscher, F. Schröder, M. Shvetsov, I. Sieber, G. Simonis, H.J. Ulrich, R. Wayand, S. Weber, M. Weiler, T. Williamson, S. Wöhrmann, C. Wolf, R. Anagnostou, G. Daskalakis, G. Geralis, T. 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Celik, A. Dalchenko, M. De Mattia, M. Delgado, A. Dildick, S. Eusebi, R. Gilmore, J. Huang, T. Juska, E. Kamon, T. Mueller, R. Pakhotin, Y. Patel, R. Perloff, A. Perniè, L. Rathjens, D. Safonov, A. Tatarinov, A. Ulmer, K.A. Akchurin, N. Damgov, J. De Guio, F. Dragoiu, C. Dudero, P.R. Faulkner, J. Gurpinar, E. Kunori, S. Lamichhane, K. Lee, S.W. Libeiro, T. Peltola, T. Undleeb, S. Volobouev, I. Wang, Z. Greene, S. Gurrola, A. Janjam, R. Johns, W. Maguire, C. Melo, A. Ni, H. Sheldon, P. Tuo, S. Velkovska, J. Xu, Q. Arenton, M.W. Barria, P. Cox, B. Goodell, J. Hirosky, R. Ledovskoy, A. Li, H. Neu, C. Sinthuprasith, T. Sun, X. Wang, Y. Wolfe, E. Xia, F. Clarke, C. Harr, R. Karchin, P.E. Sturdy, J. Belknap, D.A. Buchanan, J. Caillol, C. Dasu, S. Dodd, L. Duric, S. Gomber, B. Grothe, M. Herndon, M. Hervé, A. Klabbers, P. Lanaro, A. Levine, A. Long, K. Loveless, R. Perry, T. Pierro, G.A. Polese, G. Ruggles, T. Savin, A. Smith, N. Smith, W.H. Taylor, D. Woods, N. The CMS Collaboration
Subjects: Nuclear Experiment
Abstract: The Fourier coefficients v2 and v3 characterizing the anisotropy of the azimuthal distribution of charged particles produced in PbPb collisions at sNN=5.02 TeV are measured with data collected by the CMS experiment. The measurements cover a broad transverse momentum range, 110 GeV/c range, where anisotropic azimuthal distributions should reflect the path-length dependence of parton energy loss in the created medium. Results are presented in several bins of PbPb collision centrality, spanning the 60% most central events. The v2 coefficient is measured with the scalar product and the multiparticle cumulant methods, which have different sensitivities to initial-state fluctuations. The values from both methods remain positive up to pT∼60–80 GeV/c, in all examined centrality classes. The v3 coefficient, only measured with the scalar product method, tends to zero for pT≳20 GeV/c. Comparisons between theoretical calculations and data provide new constraints on the path-length dependence of parton energy loss in heavy ion collisions and highlight the importance of the initial-state fluctuations. © 2017 The Author
Published: 2018

48. Search for vectorlike light-flavor quark partners in proton-proton collisions at root s=8 TeV

Author: Sirunyan, A. M. Tumasyan, A. Adam, W. Asilar, E. and Bergauer, T. Brandstetter, J. Brondolin, E. Dragicevic, M. and Eroe, J. Flechl, M. Friedl, M. Fruehwirth, R. Ghete, V. M. Hartl, C. Hoermann, N. Hrubec, J. Jeitler, M. and Koenig, A. Kraetschmer, I. Liko, D. Matsushita, T. and Mikulec, I. Rabady, D. Rad, N. Rahbaran, B. Rohringer, H. Schieck, J. Strauss, J. Waltenberger, W. Wulz, C. -E. and Dvornikov, O. Makarenko, V. Mossolov, V. Gonzalez, J. Suarez Zykunov, V. Shumeiko, N. Alderweireldt, S. De Wolf, E. A. Janssen, X. Lauwers, J. Van De Klundert, M. and Van Haevermaet, H. Van Mechelen, P. Van Remortel, N. Van Spilbeeck, A. Abu Zeid, S. Blekman, F. D'Hondt, J. Daci, N. De Bruyn, I. Deroover, K. Lowette, S. Moortgat, S. and Moreels, L. Olbrechts, A. Python, Q. Skovpen, K. and Tavernier, S. Van Doninck, W. Van Mulders, P. Van Parijs, I. and Brun, H. Clerbaux, B. De Lentdecker, G. Delannoy, H. and Fasanella, G. Favart, L. Goldouzian, R. Grebenyuk, A. and Karapostoli, G. Lenzi, T. Leonard, A. Luetic, J. and Maerschalk, T. Marinov, A. Randle-conde, A. Seva, T. and Vander Velde, C. Vanlaer, P. Vannerom, D. Yonamine, R. and Zenoni, F. Zhang, F. Cornelis, T. Dobur, D. Fagot, A. and Gul, M. Khvastunov, I. Poyraz, D. Salva, S. and Schofbeck, R. Tytgat, M. Van Driessche, W. Yazgan, E. and Zaganidis, N. Bakhshiansohi, H. Bondu, O. Brochet, S. and Bruno, G. Caudron, A. De Visscher, S. Delaere, C. and Delcourt, M. Francois, B. Giammanco, A. Jafari, A. Komm, M. Krintiras, G. Lemaitre, V. Magitteri, A. Mertens, A. and Musich, M. Piotrzkowski, K. Quertenmont, L. Selvaggi, M. and Marono, M. Vidal Wertz, S. Beliy, N. Alda Junior, W. L. and Alves, F. L. Alves, G. A. Brito, L. Hensel, C. and Moraes, A. Pol, M. E. Rebello Teles, P. Belchior Batista Das Chagas, E. Carvalho, W. Chinellato, J. Custodio, A. Da Costa, E. M. Da Silveira, G. G. De Jesus Damiao, D. De Oliveira Martins, C. Fonseca De Souza, S. Huertas Guativa, L. M. and Malbouisson, H. Matos Figueiredo, D. Mora Herrera, C. and Mundim, L. Nogima, H. Prado Da Silva, W. L. Santoro, A. and Sznajder, A. Tonelli Manganote, E. J. Torres Da Silva De Araujo, F. Vilela Pereira, A. Ahuja, S. Bernardes, C. A. Dogra, S. Fernandez Perez Tomei, T. R. Gregores, E. M. Mercadante, P. G. Moon, C. S. Novaes, S. F. Padula, Sandra S. Romero Abad, D. Ruiz Vargas, J. C. Aleksandrov, A. Hadjiiska, R. and Iaydjiev, P. Rodozov, M. Stoykova, S. Sultanov, G. and Vutova, M. Dimitrov, A. Glushkov, I. Litov, L. Pavlov, B. Petkov, P. Fang, W. Ahmad, M. Bian, J. G. Chen, G. M. Chen, H. S. Chen, M. Chen, Y. Cheng, T. Jiang, C. H. Leggat, D. Liu, Z. Romeo, F. Ruan, M. Shaheen, S. M. Spiezia, A. Tao, J. Wang, C. Wang, Z. Zhang, H. Zhao, J. Ban, Y. Chen, G. Li, Q. Liu, S. Mao, Y. Qian, S. J. Wang, D. Xu, Z. Avila, C. Cabrera, A. and Chaparro Sierra, L. F. Florez, C. Gomez, J. P. Gonzalez Hernandez, C. F. Ruiz Alvarez, J. D. Sanabria, J. C. and Godinovic, N. Lelas, D. Puljak, I. Cipriano, P. M. Ribeiro and Sculac, T. Antunovic, Z. Kovac, M. Brigljevic, V. and Ferencek, D. Kadija, K. Mesic, B. Susa, T. Ather, M. W. and Attikis, A. Mavromanolakis, G. Mousa, J. Nicolaou, C. and Ptochos, F. Razis, P. A. Rykaczewski, H. Finger, M. and Finger, Jr., M. Carrera Jarrin, E. Assran, Y. Mahmoud, M. A. and Mahrous, A. Kadastik, M. Perrini, L. Raidal, M. and Tiko, A. Veelken, C. Eerola, P. Pekkanen, J. and Voutilainen, M. Harkonen, J. Jarvinen, T. Karimaki, V. and Kinnunen, R. Lampen, T. Lassila-Perini, K. Lehti, S. and Linden, T. Luukka, P. Tuominiemi, J. Tuovinen, E. and Wendland, L. Talvitie, J. Tuuva, T. Besancon, M. and Couderc, F. Dejardin, M. Denegri, D. Fabbro, B. Faure, J. L. Favaro, C. Ferri, F. Ganjour, S. Ghosh, S. and Givernaud, A. Gras, P. de Monchenault, G. Hamel Jarry, P. and Kucher, I. Locci, E. Machet, M. Malcles, J. Rander, J. Rosowsky, A. Titov, M. Abdulsalam, A. Antropov, I. and Baffioni, S. Beaudette, F. Busson, P. Cadamuro, L. and Chapon, E. Charlot, C. Davignon, O. de Cassagnac, R. 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Pernie, L. Rathjens, D. Safonov, A. and Tatarinov, A. Ulmer, K. A. Akchurin, N. Damgov, J. De Guio, F. Dragoiu, C. Dudero, P. R. Faulkner, J. and Gurpinar, E. Kunori, S. Lamichhane, K. Lee, S. W. and Libeiro, T. Peltola, T. Undleeb, S. Volobouev, I. Wang, Z. Greene, S. Gurrola, A. Janjam, R. Johns, W. and Maguire, C. Melo, A. Ni, H. Sheldon, P. Tuo, S. and Velkovska, J. Xu, Q. Arenton, M. W. Barria, P. Cox, B. and Hirosky, R. Ledovskoy, A. Li, H. Neu, C. and Sinthuprasith, T. Sun, X. Wang, Y. Wolfe, E. Xia, F. and Clarke, C. Harr, R. Karchin, P. E. Sturdy, J. Zaleski, S. Belknap, D. A. Buchanan, J. Caillol, C. Dasu, S. and Dodd, L. Duric, S. Gomber, B. Grothe, M. Herndon, M. and Herve, A. Hussain, U. Klabbers, P. Lanaro, A. Levine, A. and Long, K. Loveless, R. Pierro, G. A. Polese, G. and Ruggles, T. Savin, A. Smith, N. Smith, W. H. Taylor, D. and Woods, N.
Subjects: High Energy Physics::Experiment
Abstract: A search is presented for heavy vectorlike quarks (VLQs) that couple only to light quarks in proton-proton collisions at root s = 8 TeV at the LHC. The data were collected by the CMS experiment during 2012 and correspond to an integrated luminosity of 19.7 fb(-1). Both single and pair production of VLQs are considered. The single-production search is performed for down-type VLQs (electric charge of magnitude 1/3), while the pair-production search is sensitive to up-type (charge of magnitude 2/3) and down-type VLQs. Final states with at least one muon or one electron are considered. No significant excess over standard model expectations is observed, and lower limits on the mass of VLQs are derived. The lower limits range from 400 to 1800 GeV, depending on the single-production cross section and the VLQ branching fractions B to W, Z, and Higgs bosons. When considering pair production alone, VLQs with masses below 845 GeV are excluded for B(W) = 1.0, and below 685 GeV for B(W) = 0.5, B(Z) = B(H) = 0.25. The results are more stringent than those previously obtained for single and pair production of VLQs coupled to light quarks.
Published: 2018

49. Study of dijet events with a large rapidity gap between the two leading jets in pp collisions at root s=7 TeV

Author: Sirunyan, A. M. Tumasyan, A. Adam, W. Asilar, E. and Bergauer, T. Brandstetter, J. Brondolin, E. Dragicevic, M. and Ero, J. Flechl, M. Friedl, M. Fruehwirth, R. Ghete, V. M. Hartl, C. Hormann, N. Hrubec, J. Jeitler, M. and Konig, A. Kratschmer, I. Liko, D. Matsushita, T. and Mikulec, I. Rabady, D. Rad, N. Rahbaran, B. Rohringer, H. Schieck, J. Strauss, J. Waltenberger, W. Wulz, C. -E. and Dvornikov, O. Makarenko, V. Mossolov, V. Gonzalez, J. Suarez Zykunov, V. Shumeiko, N. Alderweireldt, S. De Wolf, E. A. Janssen, X. Lauwers, J. De Klundert, M. Van and Van Haevermaet, H. Van Mechelen, P. Van Remortel, N. Van Spilbeeck, A. Abu Zeid, S. Blekman, F. D'Hondt, J. Daci, N. De Bruyn, I. Deroover, K. Lowette, S. Moortgat, S. and Moreels, L. Olbrechts, A. Python, Q. Skovpen, K. and Tavernier, S. Van Doninck, W. Van Mulders, P. Van Parijs, I. and Brun, H. Clerbaux, B. De Lentdecker, G. Delannoy, H. and Fasanella, G. Favart, L. Goldouzian, R. Grebenyuk, A. and Karapostoli, G. Lenzi, T. Leonard, A. Luetic, J. and Maerschalk, T. Marinov, A. Randle-Conde, A. Seva, T. and Vander Velde, C. Vanlaer, P. Vannerom, D. Yonamine, R. and Zenoni, F. Zhang, F. Cimmino, A. Cornelis, T. Dobur, D. and Fagot, A. Gul, M. Khvastunov, I. Poyraz, D. Salva, S. Schofbeck, R. Tytgat, M. Van Driessche, W. Yazgan, E. and Zaganidis, N. Bakhshiansohi, H. Beluffi, C. Bondu, O. and Brochet, S. Bruno, G. Caudron, A. De Visscher, S. and Delaere, C. Delcourt, M. Francois, B. Giammanco, A. and Jafari, A. Komm, M. Krintiras, G. Lemaitre, V. and Magitteri, A. Mertens, A. Musich, M. Piotrzkowski, K. and Quertenmont, L. Selvaggi, M. Marono, M. Vidal Wertz, S. and Beliy, N. Alda Junior, W. L. Alves, F. L. Alves, G. A. and Brito, L. Hensel, C. Moraes, A. Pol, M. E. Teles, P. Rebello Belchior Batista Das Chagas, E. Carvalho, W. and Chinellato, J. Custodio, A. Da Costa, E. M. . Da Silveira, G. G. De Jesus Damiao, D. De Oliveira Martins, C. Fonseca De Souza, S. Huertas Guativa, L. M. Malbouisson, H. Matos Figueiredo, D. Mora Herrera, C. Mundim, L. Nogima, H. and Prado Da Silva, W. L. Santoro, A. Sznajder, A. Tonelli Manganote, E. J. Torres Da Silva De Araujo, F. Vilela Pereira, A. Ahuja, S. Bernardes, C. A. Dogra, S. Fernandez Perez Tomei, T. R. Gregores, E. M. Mercadante, P. G. Moon, C. S. and Novaes, S. F. Padula, Sandra S. Romero Abad, D. Ruiz Vargas, J. C. Aleksandrov, A. Hadjiiska, R. Iaydjiev, P. and Rodozov, M. Stoykova, S. Sultanov, G. Vutova, M. and Dimitrov, A. Glushkov, I. Litov, L. Pavlov, B. Petkov, P. Fang, W. Ahmad, M. Bian, J. G. Chen, G. M. Chen, H. S. Chen, M. Chen, Y. Cheng, T. Jiang, C. H. and Leggat, D. Liu, Z. Romeo, F. Ruan, M. Shaheen, S. M. and Spiezia, A. Tao, J. Wang, C. Wang, Z. Zhang, H. and Zhao, J. Ban, Y. Chen, G. Li, Q. Liu, S. Mao, Y. and Qian, S. J. Wang, D. Xu, Z. Avila, C. Cabrera, A. and Chaparro Sierra, L. F. Florez, C. Gomez, J. P. Gonzalez Hernandez, C. F. Ruiz Alvarez, J. D. Sanabria, J. C. and Godinovic, N. Lelas, D. Puljak, I. 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Brandt, S. Busza, W. Cali, I. A. and D'Alfonso, M. Demiragli, Z. Ceballos, G. Gomez Goncharov, M. and Hsu, D. Iiyama, Y. Innocenti, G. M. Klute, M. and Kovalskyi, D. Krajczar, K. Lai, Y. S. Lee, Y. -J. Levin, A. Luckey, P. D. Maier, B. Marini, A. C. Mcginn, C. and Mironov, C. Narayanan, S. Niu, X. Paus, C. Roland, C. and Roland, G. Salfeld-Nebgen, J. Stephans, G. S. F. Tatar, K. Velicanu, D. Wang, J. Wang, T. W. Wyslouch, B. and Benvenuti, A. C. Chatterjee, R. M. Evans, A. Hansen, P. and Kalafut, S. Kao, S. C. Kubota, Y. Lesko, Z. Mans, J. and Nourbakhsh, S. Ruckstuhl, N. Rusack, R. Tambe, N. and Turkewitz, J. Acosta, J. G. Oliveros, S. Avdeeva, E. and Bloom, K. Claes, D. R. Fangmeier, C. Suarez, R. Gonzalez and Kamalieddin, R. Kravchenko, I. Rodrigues, A. Malta Monroy, J. Siado, J. E. Snow, G. R. Stieger, B. Alyari, M. and Dolen, J. Godshalk, A. Harrington, C. Iashvili, I. and Kaisen, J. Nguyen, D. Parker, A. Rappoccio, S. and Roozbahani, B. Alverson, G. Barberis, E. Hortiangtham, A. and Massironi, A. Morse, D. M. Nash, D. Orimoto, T. De Lima, R. Teixeira Trocino, D. Wang, R. -J. Wood, D. and Bhattacharya, S. Charaf, O. Hahn, K. A. Kumar, A. Mucia, N. Odell, N. Pollack, B. Schmitt, M. H. Sung, K. and Trovato, M. Velasco, M. Dev, N. Hildreth, M. Anampa, K. Hurtado Jessop, C. Karmgard, D. J. Kellams, N. Lannon, K. Marinelli, N. Meng, F. Mueller, C. Musienko, Y. and Planer, M. Reinsvold, A. Ruchti, R. Rupprecht, N. Smith, G. Taroni, S. Wayne, M. Wolf, M. Woodard, A. and Alimena, J. Antonelli, L. Bylsma, B. Durkin, L. S. and Flowers, S. Francis, B. Hart, A. Hill, C. Ji, W. and Liu, B. Luo, W. Puigh, D. Winer, B. L. Wulsin, H. W. and Cooperstein, S. Driga, O. Elmer, P. Hardenbrook, J. and Hebda, P. Lange, D. Luo, J. Marlow, D. Medvedeva, T. and Mei, K. Ojalvo, I. Olsen, J. Palmer, C. Piroue, P. and Stickland, D. Svyatkovskiy, A. Tully, C. Malik, S. and Barker, A. Barnes, V. E. Folgueras, S. Gutay, L. Jha, M. K. Jones, M. Jung, A. W. Khatiwada, A. Miller, D. H. and Neumeister, N. Schulte, J. F. Shi, X. Sun, J. Wang, F. and Xie, W. Parashar, N. Stupak, J. Adair, A. Akgun, B. and Chen, Z. Ecklund, K. M. Geurts, F. J. M. Guilbaud, M. and Li, W. Michlin, B. Northup, M. Padley, B. P. and Roberts, J. Rorie, J. Tu, Z. Zabel, J. Betchart, B. and Bodek, A. de Barbaro, P. Demina, R. t Duh, Y. Ferbel, T. and Galanti, M. Garcia-Bellido, A. Han, J. Hindrichs, O. and Khukhunaishvili, A. Lo, K. H. Tan, P. Verzetti, M. and Ciesielski, R. Agapitos, A. Chou, J. P. Gershtein, Y. and Espinosa, T. A. Gomez Halkiadakis, E. Heindl, M. Hughes, E. and Kaplan, S. Elayavalli, R. Kunnawalkam Kyriacou, S. Lath, A. Nash, K. Osherson, M. Saka, H. Salur, S. and Schnetzer, S. Sheffield, D. Somalwar, S. Stone, R. and Thomas, S. Thomassen, P. Walker, M. Delannoy, A. G. and Foerster, M. Heideman, J. Riley, G. Rose, K. Spanier, S. and Thapa, K. Bouhali, O. Celik, A. Dalchenko, M. De Mattia, M. Delgado, A. Dildick, S. Eusebi, R. Gilmore, J. Huang, T. Juska, E. Kamon, T. Mueller, R. and Pakhotin, Y. Patel, R. Perloff, A. Pernie, L. Rathjens, D. Safonov, A. Tatarinov, A. Ulmer, K. A. Akchurin, N. and Damgov, J. De Guio, F. Dragoiu, C. Dudero, P. R. and Faulkner, J. Gurpinar, E. Kunori, S. Lamichhane, K. Lee, S. W. Libeiro, T. Peltola, T. Undleeb, S. Volobouev, I. and Wang, Z. Greene, S. Gurrola, A. Janjam, R. Johns, W. and Maguire, C. Melo, A. Ni, H. Sheldon, P. Tuo, S. and Velkovska, J. Xu, Q. Arenton, M. W. Barria, P. Cox, B. and Goodell, J. Hirosky, R. Ledovskoy, A. Li, H. Neu, C. and Sinthuprasith, T. Sun, X. Wang, Y. Wolfe, E. Xia, F. and Clarke, C. Harr, R. Karchin, P. E. Sturdy, J. and Zaleski, S. Belknap, D. A. Buchanan, J. Caillol, C. and Dasu, S. Dodd, L. Duric, S. Gomber, B. Grothe, M. and Herndon, M. Herve, A. Klabbers, P. Lanaro, A. Levine, A. and Long, K. Loveless, R. Pierro, G. A. Polese, G. and Ruggles, T. Savin, A. Smith, N. Smith, W. H. Taylor, D. and Woods, N. CMS Collaboration
Subjects: Astrophysics::High Energy Astrophysical Phenomena, High Energy Physics::Experiment, Nuclear Experiment
Abstract: Events with no charged particles produced between the two leading jets are studied in proton-proton collisions at root s = 7 TeV. The jets were required to have transverse momentum p(T)(jet) > 40 GeV and pseudorapidity 1.5 < vertical bar eta(jet)vertical bar < 4.7, and to have values of eta(jet) with opposite signs. The data used for this study were collected with the CMSdetector during low-luminosity running at the LHC, and correspond to an integrated luminosity of 8 pb(-1). Events with no charged particles with p(T) > 0.2GeV in the interval -1 < eta < 1 between the jets are observed in excess of calculations that assume no color-singlet exchange. The fraction of events with such a rapidity gap, amounting to 0.5-1% of the selected dijet sample, is measured as a function of the pT of the second-leading jet and of the rapidity separation between the jets. The data are compared to previous measurements at the Tevatron, and to perturbative quantum chromodynamics calculations based on the Balitsky-Fadin-Kuraev-Lipatov evolution equations, including different models of the non-perturbative gap survival probability.
Published: 2018

50. Search for natural supersymmetry in events with top quark pairs and photons in pp collisions at root s=8 TeV

Author: Sirunyan, A. M. Tumasyan, A. Adam, W. Asilar, E. and Bergauer, T. Brandstetter, J. Brondolin, E. Dragicevic, M. and Eroe, J. Flechl, M. Friedl, M. Fruehwirth, R. Ghete, V. M. Hartl, C. Hoermann, N. Hrubec, J. Jeitler, M. and Koenig, A. Kraetschmer, I. Liko, D. Matsushita, T. and Mikulec, I. Rabady, D. Rad, N. Rahbaran, B. Rohringer, H. Schiecki, J. Strauss, J. Waltenberger, W. Wulzi, C. -E. Dvornikov, O. Makarenko, V. Mossolov, V. Gonzalez, J. Suarez Zykunov, V. Shumeiko, N. Alderweireldt, S. De Wolf, E. A. Janssen, X. Lauwers, J. Van De Klundert, M. and Van Haevermaet, H. Van Mechelen, P. Van Remortel, N. Van Spilbeeck, A. Abu Zeid, S. Blekman, F. D'Hondt, J. Daci, N. De Bruyn, I. Deroover, K. Lowette, S. Moortgat, S. and Moreels, L. Olbrechts, A. Python, Q. Skovpen, K. and Tavernier, S. Van Doninck, W. Van Mulders, P. Van Parijs, I. and Brun, H. Clerbaux, B. De Lentdecker, G. Delannoy, H. and Fasanella, G. Favart, L. Goldouzian, R. Grebenyuk, A. and Karapostoli, G. Lenzi, T. Leonard, A. Luetic, J. and Maerschalk, T. Marinov, A. Randle-conde, A. Seva, T. and Vander Velde, C. Vanlaer, P. Vannerom, D. Yonamine, R. and Zenoni, F. Zhang, F. Cornelis, T. Dobur, D. Fagot, A. and Gul, M. Khvastunov, I. Poyraz, D. Salva, S. and Schofbeck, R. Tytgat, M. Van Driessche, W. Verbeke, W. and Zaganidis, N. Bakhshiansohi, H. Bondu, O. Brochet, S. and Bruno, G. Caudron, A. De Visscher, S. Delaere, C. and Delcourt, M. Francois, B. Giammanco, A. Jafari, A. Komm, M. Krintiras, G. Lemaitre, V. Magitteri, A. Mertens, A. and Musich, M. Piotrzkowski, K. Quertenmont, L. Marono, M. Vidal Wertz, S. Beliy, N. Alda Junior, W. L. Alves, F. L. Alves, G. A. Brito, L. Hensel, C. Moraes, A. Pol, M. E. Rebello Teles, P. Batista Das Chagas, E. Belchior and Carvalho, W. Chinellato, J. Custodio, A. Da Costa, E. M. and Da Silveira, G. G. De Jesus Damiao, D. De Oliveira Martins, C. and Fonseca De Souza, S. Huertas Guativa, L. M. Malbouisson, H. and Matos Figueiredo, D. Mora Herrera, C. Mundim, L. Nogima, H. Prado Da Silva, W. L. Santoro, A. Sznajder, A. and Tonelli Manganote, E. J. Da Silva De Araujo, F. Torres Vilela Pereira, A. Ahuja, S. Bernardes, C. A. Dogra, S. Perez Tomei, T. R. Fernandez Gregores, E. M. Mercadante, P. C. and Moon, C. S. Novaes, S. F. Padula, Sandra S. Romero Abad, D. and Ruiz Vargas, J. C. Aleksandrov, A. Hadjiiska, R. and Iaydjiev, P. Rodozov, M. Stoykova, S. Sultanov, G. and Vutova, M. Dimitrov, A. Glushkov, I. Litov, L. Pavlov, B. Petkov, P. Fang, W. Gao, X. Ahmad, M. Bian, J. G. and Chen, G. M. Chen, H. S. Chen, M. Chen, Y. Cheng, T. and Jiang, C. H. Leggat, D. Liu, Z. Romeo, F. Ruan, M. and Shaheen, S. M. Spiezia, A. Tao, J. Wang, C. Wang, Z. and Yazgan, E. Zhang, H. Zhao, J. Ban, Y. Chen, G. and Li, Q. Liu, S. Mao, Y. Qian, S. J. Wang, D. Xu, Z. and Avila, C. Cabrera, A. Chaparro Sierra, L. F. Florez, C. and Gomez, J. P. Gonzalez Hernandez, C. F. Ruiz Alvarez, J. D. and Sanabria, J. C. Godinovic, N. Lelas, D. Puljak, I. and Cipriano, P. M. Ribeiro Sculac, T. Antunovic, Z. Kovac, M. and Brigljevic, V. Ferencek, D. Kadija, K. Mesic, B. and Susa, T. Ather, M. W. Attikis, A. Mavromanolakis, G. and Mousa, J. Nicolaou, C. Ptochos, F. Razis, P. A. and Rykaczewski, H. Finger, M. Finger, Jr., M. Carrera Jarrin, E. Assran, Y. Mahmoud, M. A. Mahrous, A. Kadastik, M. and Perrini, L. Raidal, M. Tiko, A. Veelken, C. Eerola, P. Pekkanen, J. Voutilainen, M. Harkonen, J. Jarvinen, T. Karimaki, V. Kinnunen, R. Lampen, T. Lassila-Perini, K. Lehti, S. Linden, T. Luukka, P. Tuominiemi, J. and Tuovinen, E. Wendland, L. Talvitie, J. Tuuva, T. and Besancon, M. Couderc, F. Dejardin, M. Denegri, D. and Fabbro, B. Faure, J. L. Favaro, C. Ferri, F. Ganjour, S. and Ghosh, S. Givernaud, A. Gras, P. de Monchenault, G. Hamel Jarry, P. Kucher, I. Locci, E. Machet, M. and Maleles, J. Rander, J. Rosowsky, A. Titov, M. and Abdulsalam, A. Antropov, I. Baffioni, S. Beaudette, F. and Busson, P. Cadamuro, L. Chapon, E. Charlot, C. Davignon, O. de Cassagnac, R. Granier Jo, M. Lisniak, S. Lobanov, A. Mine, P. Nguyen, M. Ochando, C. Ortona, G. and Paganini, P. Pigard, P. Regnard, S. Salerno, R. Sirois, Y. Leiton, A. G. Stahl Strebler, T. Yilmaz, Y. Zabi, A. and Zghiche, A. Agram, J. -L. Andrea, J. Bloch, D. Brom, J. -M. Buttignol, M. Chabert, E. C. Chanon, N. Collard, C. Conte, E. Coubez, X. Fontaine, J. -C. Gele, D. and Goerlach, U. Le Bihan, A. -C. Van Hove, P. Gadrat, S. and Beauceron, S. Bernet, C. Boudoul, G. Montoya, C. A. Carrillo and Chierici, R. Contardo, D. Courbon, B. Depasse, P. El Mamouni, H. Fay, J. Finco, L. Gascon, S. Gouzevitch, M. and Grenier, G. Ille, B. Lagarde, F. Laktineh, I. B. and Lethuillier, M. Mirabito, L. Pequegnot, A. L. Perries, S. and Popov, A. Sordini, V. Vander Donckt, M. Verdier, P. and Viret, S. Khvedelidze, A. Tsamalaidze, Z. Autermann, C. and Beranek, S. Feld, L. Kiesel, M. K. Klein, K. Lipinski, M. Preuten, M. Schomakers, C. Schulz, J. Verlage, T. and Albert, A. Brodski, M. Dietz-Laursonn, E. Duchardt, D. and Endres, M. Erdmann, M. Erdweg, S. Esch, T. Fischer, R. and Gueth, A. Hamer, M. Hebbeker, T. Heidemann, C. and Hoepfner, K. Knutzen, S. Merschmeyer, M. Meyer, A. and Millet, P. Mukherjee, S. Olschewski, M. Padeken, K. and Pook, T. Radziej, M. Reithler, H. Rieger, M. Scheuch, F. and Sonnenschein, L. Teyssier, D. Thueer, S. Cherepanov, V. and Fluegge, G. Kargoll, B. Kress, T. Kuensken, A. and Lingemann, J. Mueller, T. Nehrkorn, A. Nowack, A. and Pistone, C. Pooth, O. Stahl, A. Martin, M. Aldaya Arndt, T. Asawatangtrakuldee, C. Beernaert, K. Behnke, O. and Behrens, U. Bin Anuar, A. A. Borras, K. Campbell, A. and Connor, P. Contreras-Campana, C. Costanza, F. Pardos, C. Diez Dolinska, G. Eckerlin, G. Eckstein, D. Eichhorn, T. and Eren, E. Gallo, E. Garcia, J. Garay Geiser, A. and Gizhko, A. Luyando, J. M. Grados Grohsjean, A. Gunnellini, P. Harb, A. Hauk, J. Hempel, M. Jung, H. and Kalogeropoulos, A. Karacheban, O. Kasemann, M. Keaveney, J. and Kleinwort, C. Korol, I. Kruecker, D. Lange, W. and Lelek, A. Lenz, T. Leonard, J. Lipka, K. Lohmann, W. and Mankel, R. Melzer-Pellmann, I. -A. Meyer, A. B. Mittag, G. and Mnich, J. Mussgiller, A. Ntomari, E. Pitzl, D. and Placakyte, R. Raspereza, A. Roland, B. Sahin, M. Oe. and Saxena, P. Schoerner-Sadenius, T. Spannagel, S. Stefaniuk, N. Van Onsem, G. P. Walsh, R. Wissing, C. Blobel, V. and Vignali, M. Centis Draeger, A. R. Dreyer, T. Garutti, E. and Gonzalez, D. Haller, J. Hoffmann, M. Junkes, A. Klanner, R. Kogler, R. Kovalchuk, N. Kurz, S. Lapsien, T. and Marchesini, I. Marconi, D. Meyer, M. Niedziela, M. and Nowatschin, D. Pantaleon, F. Peiffer, T. Perieanu, A. and Scharf, C. Schleper, P. Schmidt, A. Schumann, S. and Schwandt, J. Sonneveld, J. Stadie, H. Steinbrtick, G. and Stober, F. M. Stoever, M. Tholen, H. Troendle, D. Usai, E. Vanelderen, L. Vanhoefer, A. Vormwald, B. Akbiyik, M. and Barth, C. Baur, S. Baus, C. Berger, J. Butz, E. and Caspart, R. Chwalek, T. Colombo, F. De Boer, W. and Dierlamm, A. Fink, S. Freund, B. Friese, R. Giffels, M. and Gilbert, A. Goldenzweig, P. Haitz, D. Hartmann, F. and Heindl, S. M. Husemann, U. Kassel, F. Katkov, I. and Kudella, S. Mildner, H. Mozer, M. U. Mueller, Th. and Plagge, M. Quast, G. Rabbertz, K. Roecker, S. Roscher, F. Schroeder, M. Shvetsov, I. Sieber, G. Simonis, H. J. and Ulrich, R. Wayand, S. Weber, M. Weiler, T. and Williamson, S. Woehrmann, C. Wolf, R. Anagnostou, G. and Daskalakis, G. Geralis, T. Giakoumopoulou, V. A. Kyriakis, A. Loukas, D. Topsis-Giotis, I. Kesisoglou, S. and Panagiotou, A. Saoulidou, N. Tziaferi, E. Kousouris, K. and Evangelou, I. Flouris, G. Foudas, C. Kokkas, P. Loukas, N. Manthos, N. Papadopoulos, I. Paradas, E. Triantis, F. A. Filipovic, N. Pasztor, G. Bencze, G. Hajdu, C. and Horvath, D. Sikler, F. Veszpremi, V. Vesztergombi, G. and Zsigmond, A. J. Beni, N. Czellar, S. Karancsi, J. and Makovec, A. Molnar, J. Szillasi, Z. Bartok, M. Raics, P. and Trocsanyi, Z. L. Ujvari, B. Choudhury, S. Komaragiri, J. R. Bahinipati, S. Bhowmik, S. Mal, P. Mandal, K. and Nayak, A. Sahoo, D. K. Sahoo, N. Swain, S. K. Bansal, S. and Beri, S. B. Bhatnagar, V. Bhawandeep, U. Chawla, R. and Kalsi, A. K. Kaur, A. Kaur, M. Kumar, R. Kumari, P. and Mehta, A. Mittal, M. Singh, J. B. Walia, G. Kumar, Ashok and Bhardwaj, A. Choudhary, B. C. Garg, R. B. Keshri, S. and Kumar, A. Malhotra, S. Naimuddin, M. Ranjan, K. Sharma, R. Sharma, V. Bhattacharya, R. Bhattacharya, S. and Chatterjee, K. Dey, S. Dutt, S. Dutta, S. Ghosh, S. and Majumdar, N. Modak, A. Mondal, K. Mukhopadhyay, S. and Nandan, S. Purohit, A. Roy, A. Roy, D. Chowdhury, S. Roy and Sarkar, S. Sharan, M. Thakur, S. Behera, P. K. and Chudasama, R. Dutta, D. Jha, V. Kumar, V. Mohanty, A. K. and Netrakanti, P. K. Pant, L. M. Shukla, P. Topkar, A. and Aziz, T. Dugad, S. Kole, G. Mahakud, B. Mitra, S. and Mohanty, G. B. Parida, B. Sur, N. Sutar, B. Banerjee, S. and Dewanjee, R. K. Ganguly, S. Guchait, M. Jain, Sa. and Kumar, S. Maity, M. Majumder, G. Mazumdar, K. Sarkar, T. and Wickramage, N. Chauhan, S. Dube, S. Hegde, V. and Kapoor, A. Kothekar, K. Pandey, S. Rane, A. Sharma, S. and Chenarani, S. Tadavani, E. Eskandari Etesami, S. M. and Khakzad, M. Najafabadi, M. Mohammadi Naseri, M. Mehdiabadi, S. Paktinat Hosseinabadi, F. Rezaei Safarzadeh, B. Zeinali, M. Felcini, M. Grunewald, M. Abbrescia, M. Calabria, C. and Caputo, C. Colaleo, A. Creanza, D. Cristella, L. De Filippis, N. De Palma, M. Fiore, L. Iaseili, G. Maggi, G. Maggi, M. Miniello, G. My, S. Nuzzo, S. Pompili, A. Pugliese, G. Radogna, R. Ranieri, A. Selvaggi, G. and Sharma, A. Silvestris, L. Venditti, R. Verwilligen, P. and Abbiendi, G. Battilana, C. Bonacorsi, D. and Braibant-Giacomelli, S. Brigliadori, L. Campanini, R. and Capiluppi, P. Castro, A. Cavallo, F. R. Chhibra, S. S. and Codispoti, G. Cuffiani, M. Dallavalle, G. M. Fabbri, F. and Fanfani, A. Fasanella, D. Giacomelli, P. Grandi, C. and Guiducci, L. Marcellini, S. Masetti, G. Montanari, A. and Navarria, F. L. Perrotta, A. Rossi, A. M. Rovelli, T. and Siroli, G. P. Tosi, N. Albergo, S. Costa, S. Di Mattia, A. Giordano, F. Potenza, R. Tricomi, A. Tuve, C. and Barbagli, G. Ciulli, V. Civinini, C. D'Alessandro, R. and Focardi, E. Lenzi, P. Meschini, M. Paoletti, S. Russo, L. Sguazzoni, G. Strom, D. Viliani, L. Benussi, L. and Bianco, S. Fabbri, F. Piccolo, D. Primavera, F. and Calvelli, V. Ferro, F. Monge, M. R. Robutti, E. Tosi, S. and Brianza, L. Brivio, F. Ciriolo, V. Dinardo, M. E. and Fiorendi, S. Gennai, S. Ghezzi, A. Govoni, P. Malberti, M. Malvezzi, S. Manzoni, R. A. Menasce, D. Moroni, L. and Paganoni, M. Pedrini, D. Pigazzini, S. Ragazzi, S. and de Fatis, T. Tabarelli Buontempo, S. Cavallo, N. De Nardo, G. Di Guida, S. Fabozzi, F. Fienga, F. Iorio, A. O. M. and Lista, L. Mcola, S. Paolucci, P. Sciacca, C. and Thyssen, F. Azzi, P. Bacchetta, N. Benato, L. Bisello, D. Boletti, A. Carlin, R. De Oliveira, A. Carvalho Antunes and Checchia, P. Dall'Osso, M. Manzano, P. De Castro Dorigo, T. Dosselli, U. Gasparini, F. Gasparini, U. Gozzelino, A. Lacaprara, S. Margoni, M. Meneguzzo, A. T. Pazzini, J. Pozzobon, N. Ronchese, P. Simonetto, F. Torassa, E. and Zanetti, M. Zotto, P. Zumerle, G. Braghieri, A. and Fallavollita, F. Magnani, A. Montagna, P. Ratti, S. P. and Re, V. Ressegotti, M. Riccardi, C. Salvini, P. Vai, I. and Vitulo, P. Solestizi, L. Alunni Bilei, G. M. and Ciangottini, D. Fano, L. Lariccia, P. Leonardi, R. and Mantovani, G. Mariani, V. Menichelli, M. Saha, A. and Santocchia, A. Androsov, K. Azzurri, P. Bagliesi, G. and Bernardini, J. Boccali, T. Castaldi, R. Ciocci, M. A. and Dell'Orso, R. Fedi, G. Giassi, A. Grippo, M. T. Ligabue, F. Lomtadze, T. Martini, L. Messineo, A. Palla, F. and Rizzi, A. Savoy-Navarro, A. Spagnolo, P. Tenchini, R. and Tonelli, G. Venturi, A. Verdini, P. C. Barone, L. and Cavallari, F. Cipriani, M. Del Re, D. Diemoz, M. Gelli, S. Longo, E. Margaroli, F. Marzocchi, B. Meridiani, P. and Organtini, G. Paramatti, R. Preiato, F. Rahatlou, S. and Rovelli, C. Santanastasio, F. Amapane, N. Arcidiacono, R. and Argiro, S. Arneodo, M. Bartosik, N. Bellan, R. and Biino, C. Cartiglia, N. Cenna, F. Costa, M. Covarelli, R. Degano, A. Demaria, N. Kiani, B. Mariotti, C. and Maselli, S. Migliore, E. Monaco, V. Monteil, E. Monteno, M. Obertino, M. M. Pacher, L. Pastrone, N. Pelliccioni, M. Angioni, G. L. Pinna Ravera, F. Romero, A. Ruspa, M. and Sacchi, R. Shchelina, K. Sola, V. Solano, A. and Staiano, A. Traczyk, P. Belforte, S. Casarsa, M. and Cossutti, F. Della Ricca, G. Zanetti, A. Kim, D. H. Kim, G. N. Kim, M. S. Lee, J. Lee, S. Lee, S. W. Oh, Y. D. Sekmen, S. Son, D. C. Yang, Y. C. Lee, A. Kim, H. and Cifuentes, J. A. Brochero Goh, J. Kim, T. J. Cho, S. and Choi, S. Go, Y. Gyun, D. Ha, S. Hong, B. Jo, Y. and Kim, Y. Lee, K. Lee, K. S. Lee, S. Lim, J. Park, S. K. Roh, Y. Almond, J. Kim, J. Lee, H. Oh, S. B. and Radburn-Smith, B. C. Seo, S. H. 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Olszewski, M. and Pyskir, A. Walczak, M. Bargassa, P. Silva, C. Beira Da Cruz E. Calpas, B. Di Francesco, A. Faccioli, P. Gallinaro, M. Hollar, J. Leonardo, N. Lloret Iglesias, L. and Nemallapudi, M. V. Seixas, J. Toldaiev, O. Vadruccio, D. and Varela, J. Afanasiev, S. Bunin, P. Gavrilenko, M. and Golutvin, I. Gorbunov, I. Kamenev, A. Karjavin, V. and Laney, A. Malakhov, A. Matveev, V. Palichik, V. and Perelygin, V. Shmatov, S. Shulha, S. Skatchkov, N. and Smirnov, V. Voytishin, N. Zarubin, A. Chtchipounov, L. and Golovtsov, V. Ivanov, Y. Kim, V. Kuznetsova, E. Murzin, V. Oreshkin, V. Sulimov, V. Vorobyev, A. Andreev, Yu. and Dermenev, A. Gninenko, S. Golubev, N. Karneyeu, A. and Kirsanov, M. Krasnikov, N. Pashenkov, A. Tlisov, D. and Toropin, A. Epshteyn, V. Gavrilov, V. Lychkovskaya, N. and Popov, V. Pozdnyakov, I. Safronov, G. Spiridonov, A. and Toms, M. Vlasov, E. Zhokin, A. Aushev, T. Bylinkin, A. and Chistov, R. Danilov, M. Zhemchugov, E. Andreev, V. and Azarkin, M. Dremin, I. 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Brandt, S. Busza, W. Cali, I. A. D'Alfonso, M. Demiragli, Z. Ceballos, G. Gomez and Goncharov, M. Hsu, D. Iiyama, Y. Innocenti, G. M. Klute, M. Kovalskyi, D. Krajczar, K. Lai, Y. S. Lee, Y. -J. and Levin, A. Luckey, P. D. Maier, B. Marini, A. C. Mcginn, C. Mironov, C. Narayanan, S. Niu, X. Paus, C. and Roland, C. Roland, G. Salfeld-Nebgen, J. Stephans, G. S. F. and Tatar, K. Velicanu, D. Wang, J. Wang, T. W. and Wyslouch, B. Benvenuti, A. C. Chatterjee, R. M. Evans, A. and Hansen, P. Kalafut, S. Kao, S. C. Kubota, Y. Lesko, Z. Mans, J. Nourbakhsh, S. Ruckstuhl, N. Rusack, R. and Tambe, N. Turkewitz, J. Acosta, J. G. Oliveros, S. and Avdeeva, E. Bloom, K. Claes, D. R. Fangmeier, C. Suarez, R. Gonzalez Kamalieddin, R. Kravchenko, I. Rodrigues, A. Malta Monroy, J. Siado, J. E. Snow, G. R. Stieger, B. and Alyari, M. Dolen, J. Godshalk, A. Harrington, C. and Iashvili, I. Nguyen, D. Parker, A. Rappoccio, S. and Roozbahani, B. Alverson, G. Barberis, E. Hortiangtham, A. and Massironi, A. Morse, D. M. Nash, D. Orimoto, T. De Lima, R. Teixeira Trocino, D. Wang, R. -J. Wood, D. and Bhattacharya, S. Charaf, O. Hahn, K. A. Mucia, N. Odell, N. Pollack, B. Schmitt, M. H. Sung, K. Trovato, M. and Velasco, M. Dev, N. Hildreth, M. Anampa, K. Hurtado and Jessop, C. Karmgard, D. J. Kellams, N. Lannon, K. and Marinelli, N. Meng, F. Mueller, C. Musienko, Y. Planer, M. Reinsvold, A. Ruchti, R. Rupprecht, N. Smith, G. and Taroni, S. Wayne, M. Wolf, M. Woodard, A. Alimena, J. and Antonelli, L. Bylsma, B. Durkin, L. S. Flowers, S. and Francis, B. Hart, A. Hill, C. Ji, W. Liu, B. Luo, W. and Puigh, D. Winer, B. L. Wulsin, H. W. Cooperstein, S. and Driga, O. Elmer, P. Hardenbrook, J. Hebda, P. Lange, D. and Luo, J. Marlow, D. Medvedeva, T. Mei, K. Ojalvo, I. and Olsen, J. Palmer, C. Piroue, P. Stickland, D. and Svyatkovskiy, A. Tully, C. Malik, S. Barker, A. Barnes, V. E. Folgueras, S. Gutay, L. Jha, M. K. Jones, M. and Jung, A. W. Khatiwada, A. Miller, D. H. 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Pakhotin, Y. Patel, R. and Perloff, A. Pernie, L. Rathjens, D. Safonov, A. and Tatarinov, A. Ulmer, K. A. Akchurin, N. Damgov, J. De Guio, F. Dragoiu, C. Dudero, P. R. Faulkner, J. and Gurpinar, E. Kunori, S. Lamichhane, K. Lee, S. W. and Libeiro, T. Peltola, T. Undleeb, S. Volobouev, I. Wang, Z. Greene, S. Gurrola, A. Janjam, R. Johns, W. and Maguire, C. Melo, A. Ni, H. Sheldon, P. Tuo, S. and Velkovska, J. Xu, Q. Arenton, M. W. Barria, P. Cox, B. and Hirosky, R. Ledovskoy, A. Li, H. Neu, C. and Sinthuprasith, T. Sun, X. Wang, Y. Wolfe, E. Xia, F. and Clarke, C. Harr, R. Karchin, P. E. Sturdy, J. Zaleski, S. Belknap, D. A. Buchanan, J. Caillol, C. Dasu, S. and Dodd, L. Duric, S. Comber, B. Grothe, M. Herndon, M. and Herve, A. Hussain, U. Klabbers, P. Lanaro, A. Levine, A. and Long, K. Loveless, R. Pierro, G. A. Polese, G. and Ruggles, T. Savin, A. Smith, N. Smith, W. H. Taylor, D. and Woods, N. CMS Collaboration
Subjects: High Energy Physics::Phenomenology, High Energy Physics::Experiment
Abstract: Results are presented from a search for natural gauge-mediated supersymmetry (SUSY) in a scenario in which the top squark is the lightest squark, the next-to-lightest SUSY particle is a bino-like neutralino, and the lightest SUSY particle is the gravitino. The strong production of top squark pairs can produce events with pairs of top quarks and neutralinos, with each bino-like neutralino decaying to a photon and a gravitino. The search is performed using a sample of pp collision data accumulated by the CMS experiment at root s = 8 TeV, corresponding to an integrated luminosity of 19.7 fb(-1). The final state consists of a lepton (electron or muon), jets, and one or two photons. The imbalance in transverse momentum in the events is compared with the expected spectrum from standard model processes. No excess event yield is observed beyond the expected background, and the result is interpreted in the context of a general model of gauge-mediated SUSY breaking that leads to exclusion of top squark masses below 650-730 GeV.
Published: 2018

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