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2. Contents Vol. 55, 1990

Author

J. Peters, A. Schinzel, Christopher J. Rawlings, J.L. Mandel, M. Tolley, S. Mercer, B. Byth, M.V. Bell, S. Povey, D. Goudie, N.C. Dracopoli, A. Geurts van Kessel, B.J.B. Keats, I.W. Craig, J. Schmidtke, T. Gedde-Dahl, P. Williamson, C. Junien, E. Solomon, C.J. Rawlings, F. Ricciuti, M. Farrall, S.T. Reeders, M.T Davisson, N.E. Simpson, S.L. Sherman, J. Weissenbach, S. Trumper, D.P. Doolittle, V. Reed, S. Malcolm, D.J. Cockburn, A. Hare, N.K. Spurr, Veronica van Heyningen, D.C. Wallace, R.H.Y. Lam, G.B. van Ommen, A.L. Hillyard, J. Ott, R.L. Nussbaum, J.M. Shoffner, H. Donis-Keller, C.E. Hildebrand, S. Malik, G. Gillett, R. Daniels, F. Mitelman, K.E. Davies, B. Maidak, A.M. Bowcock, J.A. Marshall Graves, P. Pearson, J. Walters, B. Carritt, B.S. Emanuel, T. Doyle, R.E. Lucier, S. Riley, R. Williamson, D. Lindenbaum, Y. Nakamura, J. Borrow, J.M. Trent, T.A. Donlon, C. Jones, A.G. Searle, G.R. Sutherland, L.-C. Tsui, L.C. Stranc, Steve Laval, R.T. Taggart, Sir Walter F. Bodmer, M.T Lott, P. Goodfellow, N. Shimizu, E. Keirnan, Baule, D.T. Bishop, S. Renfrey, M. Leppert, S. Ruddy, M. Barnett, P.J. McAlpine, J.C. Murray, K. Kidd, Y. Kaneko, H.F. Willard, A.P. Monaco, J. Hewitt, Y. Boyd, Z. Chen, H.H. Ropers, H. Cann, C. Boucheix, F. Lewitter, H.S. Chan, S. Ghosh, D.N. Cooper, S.L. Naylor, A. Torroni, C. Porter, G.M. Hampton, C. Westbrook, V. Buckle, M. Chipperfield, T. Morris, M.A. Pericak-Vance, K.H. Grzeschik, J. Frézal, L.L. Field, L. Sefton, W.O. McBride, P.A. Lalley, S.P. Craig, A. Bowcock, R.R. Ali, A. Ziegler, M. Quitt, S.J. O'Brien, D.W. Cox, K. Cooper, M.H. Skolnick, D.R. Cox, M M Le Beau, T.B. Shows, A. Walley, D.H. Ledbetter, K. Gulati, B.R. Seizinger, R. Track, T. Ward, G.A. Bruns, and A.Y. Sakaguchi

Subjects
Botany, Genetics, Zoology, Biology, Molecular Biology, Genetics (clinical)
Published
1990
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3. Adult T-biphenotypic acute leukaemia: clinical and biological features and outcome

Author

M T, Rubio, N, Dhedin, C, Boucheix, J H, Bourhis, O, Reman, J M, Boiron, J H, Gallo, V, Lhéritier, X, Thomas, D, Fière, and J P, Vernant

Subjects
Adult, Male, Leukemia, T-Cell, Daunorubicin, Immunophenotyping, Leukemia, Myeloid, Acute, Treatment Outcome, Vincristine, Acute Disease, Antineoplastic Combined Chemotherapy Protocols, Cytogenetic Analysis, Humans, Prednisone, Idarubicin, Cyclophosphamide, Biomarkers, Retrospective Studies
Abstract

Biphenotypic acute leukaemia with T-lymphoid and myeloid markers is rare and poorly documented. In the Leucemie Aigue Lymphoblastique de l'Adulte (LALA) prospective trial (LALA 94) of treatment for adult acute lymphoblastic leukaemia (ALL), seven patients (0.86%) had T-biphenotypic forms. The clinical and biological characteristics and outcome of these seven patients are reported here. The patients' median age was 35 years. At diagnosis, all had a tumoural syndrome and five had a mediastinal mass. In all the cases, leukaemic cells expressed myeloid and lymphoid markers. Two patients (28%) entered complete remission (CR) after induction chemotherapy. Four of the five remaining and assessable patients entered CR after designed salvage chemotherapy with mitoxantrone and high-dose cytosine arabinoside. Three patients are currently in CR. Three patients died, from treatment toxicity in two cases and progressive disease in one case. One patient relapsed 6 months after allogeneic bone marrow transplantation and is still alive. Thus, biphenotypic T-acute leukaemia is clinically frequently associated with mediastinal involvement and the response to conventional chemotherapy used in ALL is poor. However, sustained CR can be achieved by salvage chemotherapy combining an intercalating agent with high-dose cytosine arabinoside, as used in acute myeloid leukaemia.

Published
2003

4. Autologous BMT for post-remission therapy in adult ALL: an immunological approach. For The French Group of Therapy of Adult ALL

Author

E, Racadot, C, Sebban, C, Boucheix, B, David, M, Attal, J, Rieffers, C, Gisselbrecht, J P, Vernant, X, Troussard, and P, Hervé

Subjects
Adult, Adolescent, Bone Marrow Purging, Humans, Middle Aged, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Bone Marrow Transplantation, Immunophenotyping
Abstract

Among patients included in the multicentric trial ALL87, 95 patients were randomly allocated to purged ABMT arm for post-remission therapy. Immunological phenotyping performed in patients at diagnosis allowed to assigned 51 patients (54%) to the B lineage and 34 patients (36%) to the T lineage. Only 64 patients (67%) actually received ABMT mainly because of early relapses. Fifty-two patients were depleted according to the protocol: 25 B-ALL were depleted with CD10+CD19 mAbs, 19 T-ALL with CD2+CD5+CD7 mAbs and 8 patients received an Asta-Z purged BMT. Among the 12 remaining patients, 4 received Asta-Z purged BMT and 8 an unpurged one. Using an intention to treat analysis, overall survival and event free survival were similar to results observed in chemotherapy group. This study emphasizes the importance of a precise phenotyping at ALL diagnosis which allows specific immunologic bone marrow purging for ABMT.

Published
1994

7. Applications cliniques des anticorps monoclonaux

Author

C. Boucheix

Subjects
Anticorps monoclonal, medicine.drug_class, Lymphocyte, Gastroenterology, Radioimmunoassay, Elisa assay, Biology, Monoclonal antibody, Molecular biology, medicine.anatomical_structure, Internal Medicine, medicine, Immunohistochemistry, Typing, Bone marrow
Published
1985
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8. Abstracts of workshop presentations (Part 15 of 16)

Author

G. Echard, A.J. Pakstis, P.M. Conneally, Lap-Chee Tsui, N. Van Cong, H. Van den Berghe, B. Olaisen, P.L. Pearson, H.H. Kazazian, Duncan Shaw, S.L. Naylor, Hans Eiberg, J.M. Trent, J.C. Kaplan, G.R. Sutherland, N. Créau-Goldberg, D.W. Cox, M.T. Davisson, T.H. Roderick, J.N. Guidi, S.J. O'Brien, H.H. Ropers, J.F. Mattei, D.P. Doolittle, P.J. McAlpine, J.F. Gusella, H.F. Willard, K.E. Davies, M. Fellous, J.-L. Mandel, R.C. Doute, Victor A. McKusick, T.B. Shows, G.A. Bruns, N.E. Morton, T. Gedde-Dahl, B.J.B. Keats, J.J. Wasmuth, Pierre Maroteaux, J.M. Lalouel, J. Weissenbach, C. Junien, P.A. Lalley, Anne Spence, C. Boucheix, B. Carritt, Jean Frézal, J.M. Graves, C.D. Bloomfield, Kenneth K. Kidd, J.E. Womack, and A.Y. Sakaguchi

Subjects
Genetics, Library science, Biology, Bioinformatics, Molecular Biology, Genetics (clinical)
Published
1987
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9. Abstracts of workshop presentations pp. 1106-1116

Author

F. Mitelman, O.W. McBride, C. Park, F.H. Ruddle, L.L. Field, S.L. Sherman, S.T. Reeders, R.C. Douté, D. Ryan, J.M. Puck, C.E. Hildebrand, W.P. Alles, K.K. Kidd, M M Le Beau, A.M. Bowcock, R.L. Miller, M.A. Spence, T.H. Roderick, R.K. Track, G.R. Sutherland, J.-L. Mandel, D.R. Cox, M. Conneally, M.L. Mador, Frank H. Ruddle, A. Bale, E. Solomon, T.G. Berent, D.P. Doolittle, G. Romeo, A.J. Pakstis, K. Kubzdela, M.E. Hawley, T.A. Donlon, P.N. Goodfellow, R.L. Nussbaum, T.B. Shows, N. Creau-Goldberg, G.A.P Bruns, J. Weissenbach, M. Farrall, R.E. Ferrell, J.A. Rogers, M.A. FergusonSmith, K.E. Davies, A. Schinzel, J.A.M. Graves, J.J. Wasmuth, M.A. Pericak-Vance, L. Giuffra, F. Ricciuti, G.L. Schiff, A.L. Hillyard, P.J. McAlpine, M.T. Davisson, C. Junien, G. Hutchings, Y. Kaneko, D.H. Ledbetter, B. Carritt, N.E. Simpson, J. Ott, P.A. Lalley, Kenneth K. Kidd, H.S. Chan, J.E. Womack, C.T. Falk, H.-H. Ropers, D.T. Bishop, S. Povey, S.L. Naylor, H. Donis-Keller, D.W. Cox, J. Schmidtke, I.W. Craig, D.F. Barker, L.C. Stranc, L.-C. Tsui, J. Frézal, J. Gelernter, K.D. Smith, D.C. Wallace, P. Pearson, K.H. Buetow, P. Cartwright, P.S. Harper, S.J. O'Brien, M. Litt, N.K. Spurr, F. Lewitter, M.L. Cavanaugh, J.C. Murray, M. Smith, B. Keats, J.-C. Kaplan, H.F. Willard, C. Boucheix, B.S. Emanuel, and J.M. Trent

Subjects
Genetics, Library science, Biology, Molecular Biology, Genetics (clinical)
Published
1989
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10. Subject index Vol. 46, 1987

Author

N.E. Morton, A.Y. Sakaguchi, G.R. Sutherland, Victor A. McKusick, H.H. Ropers, J. Weissenbach, T.B. Shows, P.A. Lalley, Hans Eiberg, J.C. Kaplan, G.A. Bruns, Duncan Shaw, D.W. Cox, P.L. Pearson, C.D. Bloomfield, Kenneth K. Kidd, T.H. Roderick, S.L. Naylor, J.M. Trent, T. Gedde-Dahl, A.J. Pakstis, P.J. McAlpine, J.F. Gusella, H.F. Willard, J.M. Lalouel, J.N. Guidi, P.M. Conneally, J.E. Womack, N. Van Cong, D.P. Doolittle, J.F. Mattei, C. Boucheix, Lap-Chee Tsui, S.J. O'Brien, N. Créau-Goldberg, M. Fellous, J.J. Wasmuth, B. Olaisen, C. Junien, H.H. Kazazian, G. Echard, H. Van den Berghe, Anne Spence, B.J.B. Keats, M.T. Davisson, K.E. Davies, J.-L. Mandel, B. Carritt, Jean Frézal, J.M. Graves, Pierre Maroteaux, and R.C. Doute

Subjects
Index (economics), Statistics, Genetics, Subject (documents), Biology, Molecular Biology, Genetics (clinical)
Published
1987
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11. Abstracts of workshop presentations (Part 12 of 16)

Author

H.F. Willard, G.R. Sutherland, B.J.B. Keats, J.M. Trent, P.M. Conneally, H.H. Kazazian, Pierre Maroteaux, J.F. Mattei, J.N. Guidi, G. Echard, T. Gedde-Dahl, N. Van Cong, A.Y. Sakaguchi, D.W. Cox, J.J. Wasmuth, A.J. Pakstis, C. Boucheix, Lap-Chee Tsui, R.C. Doute, J.C. Kaplan, H.H. Ropers, S.J. O'Brien, N. Créau-Goldberg, H. Van den Berghe, P.L. Pearson, S.L. Naylor, M. Fellous, B. Olaisen, C.D. Bloomfield, J. Weissenbach, D.P. Doolittle, G.A. Bruns, N.E. Morton, Victor A. McKusick, M.T. Davisson, K.E. Davies, J.-L. Mandel, T.B. Shows, P.A. Lalley, Duncan Shaw, T.H. Roderick, J.M. Lalouel, Kenneth K. Kidd, Hans Eiberg, P.J. McAlpine, J.E. Womack, J.F. Gusella, C. Junien, Anne Spence, B. Carritt, Jean Frézal, and J.M. Graves

Subjects
Genetics, Library science, Biology, Bioinformatics, Molecular Biology, Genetics (clinical)
Published
1987
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12. Contents, Vol. 46, 1987/ Title Page / Table of Contents

Author

Kenneth K. Kidd, J.E. Womack, N.E. Morton, H.H. Ropers, G.A. Bruns, J.C. Kaplan, S.J. O'Brien, N. Van Cong, M. Fellous, Pierre Maroteaux, P.M. Conneally, J.N. Guidi, C. Junien, Anne Spence, M.T. Davisson, H.F. Willard, D.P. Doolittle, B. Carritt, Jean Frézal, Duncan Shaw, J. Weissenbach, J.M. Graves, G. Echard, K.E. Davies, J.-L. Mandel, J.F. Mattei, T.B. Shows, T.H. Roderick, R.C. Doute, B.J.B. Keats, A.J. Pakstis, J.M. Lalouel, D.W. Cox, H. Van den Berghe, G.R. Sutherland, Lap-Chee Tsui, S.L. Naylor, P.L. Pearson, J.M. Trent, P.J. McAlpine, J.F. Gusella, B. Olaisen, Hans Eiberg, N. Créau-Goldberg, A.Y. Sakaguchi, T. Gedde-Dahl, J.J. Wasmuth, H.H. Kazazian, C. Boucheix, C.D. Bloomfield, Victor A. McKusick, and P.A. Lalley

Subjects
Genetics, Library science, Table of contents, Biology, Title page, Molecular Biology, Genetics (clinical)
Published
1987
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13. Abstracts of workshop presentations (Part 9 of 16)

Author

H. Van den Berghe, J.C. Kaplan, J.M. Trent, B.J.B. Keats, J.F. Mattei, M.T. Davisson, C.D. Bloomfield, G.R. Sutherland, T. Gedde-Dahl, Pierre Maroteaux, H.H. Ropers, S.L. Naylor, K.E. Davies, J.-L. Mandel, N. Créau-Goldberg, J.N. Guidi, Victor A. McKusick, Hans Eiberg, N.E. Morton, G. Echard, A.Y. Sakaguchi, J.J. Wasmuth, N. Van Cong, R.C. Doute, P.A. Lalley, D.P. Doolittle, P.L. Pearson, H.H. Kazazian, T.B. Shows, G.A. Bruns, C. Boucheix, J. Weissenbach, H.F. Willard, S.J. O'Brien, B. Olaisen, Lap-Chee Tsui, M. Fellous, P.J. McAlpine, J.F. Gusella, J.M. Lalouel, C. Junien, D.W. Cox, P.M. Conneally, Anne Spence, B. Carritt, Jean Frézal, J.M. Graves, Duncan Shaw, Kenneth K. Kidd, T.H. Roderick, J.E. Womack, and A.J. Pakstis

Subjects
Genetics, Library science, Biology, Bioinformatics, Molecular Biology, Genetics (clinical)
Published
1987
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14. Abstracts of workshop presentations (Part 4 of 16)

Author

J.F. Mattei, J.N. Guidi, H.F. Willard, N.E. Morton, G.A. Bruns, J. Weissenbach, T. Gedde-Dahl, H. Van den Berghe, N. Van Cong, N. Créau-Goldberg, R.C. Doute, T.B. Shows, C. Boucheix, J.J. Wasmuth, J.M. Trent, A.J. Pakstis, H.H. Ropers, Hans Eiberg, S.J. O'Brien, Victor A. McKusick, H.H. Kazazian, P.J. McAlpine, J.F. Gusella, M. Fellous, A.Y. Sakaguchi, P.A. Lalley, B. Olaisen, J.C. Kaplan, G.R. Sutherland, M.T. Davisson, C.D. Bloomfield, D.P. Doolittle, S.L. Naylor, G. Echard, P.L. Pearson, K.E. Davies, J.-L. Mandel, Lap-Chee Tsui, P.M. Conneally, B.J.B. Keats, D.W. Cox, Pierre Maroteaux, J.M. Lalouel, C. Junien, Anne Spence, B. Carritt, Jean Frézal, J.M. Graves, Kenneth K. Kidd, J.E. Womack, Duncan Shaw, and T.H. Roderick

Subjects
Genetics, Library science, Biology, Molecular Biology, Genetics (clinical)
Published
1987
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15. Abstracts of workshop presentations (Part 11 of 16)

Author

J.M. Trent, T. Gedde-Dahl, M.T. Davisson, J.J. Wasmuth, K.E. Davies, J.-L. Mandel, J.C. Kaplan, G.A. Bruns, H.H. Kazazian, S.L. Naylor, P.J. McAlpine, C. Junien, J.F. Gusella, A.Y. Sakaguchi, H. Van den Berghe, J.N. Guidi, N. Van Cong, B. Olaisen, Pierre Maroteaux, S.J. O'Brien, J.F. Mattei, Anne Spence, M. Fellous, Lap-Chee Tsui, R.C. Doute, N.E. Morton, B. Carritt, Jean Frézal, P.L. Pearson, G.R. Sutherland, N. Créau-Goldberg, J.M. Graves, T.B. Shows, Kenneth K. Kidd, G. Echard, Hans Eiberg, J. Weissenbach, C. Boucheix, D.P. Doolittle, C.D. Bloomfield, Duncan Shaw, H.H. Ropers, D.W. Cox, J.E. Womack, Victor A. McKusick, B.J.B. Keats, P.M. Conneally, A.J. Pakstis, P.A. Lalley, T.H. Roderick, H.F. Willard, and J.M. Lalouel

Subjects
Genetics, Library science, Biology, Molecular Biology, Genetics (clinical)
Published
1987
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16. Abstracts of workshop presentations pp. 1023-1039

Author

L.C. Stranc, J.M. Puck, D.R. Cox, A.L. Hillyard, P.J. McAlpine, K.K. Kidd, T.B. Shows, R.E. Ferrell, Kenneth K. Kidd, S.L. Sherman, L.L. Field, B.S. Emanuel, M.L. Cavanaugh, F.H. Ruddle, J. Weissenbach, C.E. Hildebrand, A.M. Bowcock, M. Farrall, C.T. Falk, A. Bale, E. Solomon, J.A.M. Graves, N. Creau-Goldberg, G.R. Sutherland, M. Smith, D. Ryan, B. Keats, A.J. Pakstis, G. Romeo, P.N. Goodfellow, G.A.P Bruns, M.A. Spence, M.A. FergusonSmith, J. Schmidtke, F. Mitelman, J. Ott, O.W. McBride, S. Povey, D.W. Cox, S.L. Naylor, S.T. Reeders, R.L. Miller, R.C. Douté, H. Donis-Keller, K. Kubzdela, M.E. Hawley, T.A. Donlon, C. Park, N.E. Simpson, M M Le Beau, P.A. Lalley, D.F. Barker, H.-H. Ropers, M.A. Pericak-Vance, W.P. Alles, M.L. Mador, T.H. Roderick, T.G. Berent, D.C. Wallace, R.L. Nussbaum, Y. Kaneko, D.P. Doolittle, D.T. Bishop, J.-L. Mandel, J. Frézal, J. Gelernter, K.D. Smith, J.C. Murray, J.-C. Kaplan, D.H. Ledbetter, B. Carritt, K.E. Davies, A. Schinzel, P. Cartwright, S.J. O'Brien, F. Ricciuti, M. Conneally, M.T. Davisson, C. Junien, L.-C. Tsui, H.F. Willard, C. Boucheix, P.S. Harper, M. Litt, N.K. Spurr, P. Pearson, G.L. Schiff, G. Hutchings, F. Lewitter, I.W. Craig, J.E. Womack, K.H. Buetow, R.K. Track, J.J. Wasmuth, L. Giuffra, J.M. Trent, J.A. Rogers, H.S. Chan, and Frank H. Ruddle

Subjects
Genetics, Library science, Biology, Molecular Biology, Genetics (clinical)
Published
1989
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17. Abstracts of workshop presentations pp. 1075-1091

Author

J.A. Rogers, A.J. Pakstis, G.A.P Bruns, J. Weissenbach, M. Farrall, M.L. Mador, K. Kubzdela, M.E. Hawley, T.A. Donlon, A.L. Hillyard, L.C. Stranc, D.P. Doolittle, P.J. McAlpine, J.A.M. Graves, T.B. Shows, D.W. Cox, B.S. Emanuel, F.H. Ruddle, F. Mitelman, N.E. Simpson, G.L. Schiff, J.M. Puck, K.K. Kidd, D. Ryan, Frank H. Ruddle, S.L. Sherman, G. Hutchings, S. Povey, L.L. Field, J. Ott, D.R. Cox, D.H. Ledbetter, D.C. Wallace, S.L. Naylor, R.L. Miller, H.F. Willard, J.M. Trent, C.E. Hildebrand, B. Carritt, C. Boucheix, P.A. Lalley, C. Park, T.H. Roderick, R.K. Track, M. Conneally, H. Donis-Keller, P. Pearson, D.F. Barker, H.-H. Ropers, K.H. Buetow, T.G. Berent, F. Lewitter, W.P. Alles, D.T. Bishop, P.S. Harper, M. Litt, J.J. Wasmuth, N.K. Spurr, Kenneth K. Kidd, L. Giuffra, H.S. Chan, J.-L. Mandel, C.T. Falk, J.E. Womack, J. Schmidtke, J.C. Murray, J.-C. Kaplan, R.E. Ferrell, J. Frézal, J. Gelernter, K.D. Smith, M.L. Cavanaugh, M.A. Spence, I.W. Craig, M. Smith, B. Keats, F. Ricciuti, M.T. Davisson, C. Junien, L.-C. Tsui, N. Creau-Goldberg, O.W. McBride, S.T. Reeders, R.C. Douté, M M Le Beau, P. Cartwright, S.J. O'Brien, M.A. FergusonSmith, A. Bale, E. Solomon, G. Romeo, K.E. Davies, A. Schinzel, P.N. Goodfellow, R.L. Nussbaum, A.M. Bowcock, G.R. Sutherland, M.A. Pericak-Vance, and Y. Kaneko

Subjects
Genetics, Library science, Biology, Molecular Biology, Genetics (clinical)
Published
1989
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18. Abstracts of workshop presentations (Part 14 of 16)

Author

T.B. Shows, A.J. Pakstis, C. Junien, J.M. Lalouel, Anne Spence, N. Van Cong, J.N. Guidi, B. Carritt, Jean Frézal, J.M. Graves, J.M. Trent, P.J. McAlpine, J.F. Gusella, G.R. Sutherland, R.C. Doute, N.E. Morton, G. Echard, B.J.B. Keats, Victor A. McKusick, J. Weissenbach, H.H. Ropers, H. Van den Berghe, M.T. Davisson, H.F. Willard, P.A. Lalley, Hans Eiberg, C.D. Bloomfield, K.E. Davies, S.J. O'Brien, Pierre Maroteaux, J.F. Mattei, J.-L. Mandel, J.C. Kaplan, Kenneth K. Kidd, Lap-Chee Tsui, D.P. Doolittle, S.L. Naylor, M. Fellous, N. Créau-Goldberg, G.A. Bruns, P.L. Pearson, H.H. Kazazian, C. Boucheix, J.E. Womack, B. Olaisen, Duncan Shaw, D.W. Cox, T. Gedde-Dahl, A.Y. Sakaguchi, T.H. Roderick, J.J. Wasmuth, and P.M. Conneally

Subjects
Genetics, Library science, Biology, Bioinformatics, Molecular Biology, Genetics (clinical)
Published
1987
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19. Contents Vol. 51, 1989

Author

A. Bale, E. Solomon, M.A. Pericak-Vance, M. Conneally, G. Romeo, D.H. Ledbetter, B. Carritt, Y. Kaneko, P.N. Goodfellow, J.E. Womack, T.G. Berent, P.S. Harper, W.P. Alles, J. Frézal, M. Litt, N.K. Spurr, M.L. Mador, J.J. Wasmuth, J.-L. Mandel, J. Gelernter, L. Giuffra, A.J. Pakstis, F. Ricciuti, K.D. Smith, A.M. Bowcock, O.W. McBride, J. Ott, R.L. Nussbaum, S.T. Reeders, T.H. Roderick, R.C. Douté, N. Creau-Goldberg, L.L. Field, R.K. Track, M M Le Beau, G.A.P Bruns, D.P. Doolittle, G.R. Sutherland, R.E. Ferrell, F. Mitelman, C.E. Hildebrand, C.T. Falk, J.M. Trent, F.H. Ruddle, B.S. Emanuel, M.T. Davisson, N.E. Simpson, P. Pearson, M. Smith, D. Ryan, P.A. Lalley, M.A. FergusonSmith, G.L. Schiff, F. Lewitter, Frank H. Ruddle, B. Keats, A.L. Hillyard, C. Junien, G. Hutchings, I.W. Craig, P.J. McAlpine, R.L. Miller, M.A. Spence, J. Schmidtke, L.-C. Tsui, K.H. Buetow, H.S. Chan, T.B. Shows, K.E. Davies, A. Schinzel, H.-H. Ropers, D.W. Cox, P. Cartwright, S.J. O'Brien, C. Park, D.F. Barker, H.F. Willard, C. Boucheix, M.L. Cavanaugh, J. Weissenbach, M. Farrall, J.A.M. Graves, S.L. Sherman, D.R. Cox, L.C. Stranc, J.M. Puck, K.K. Kidd, K. Kubzdela, M.E. Hawley, T.A. Donlon, D.C. Wallace, H. Donis-Keller, D.T. Bishop, Kenneth K. Kidd, J.A. Rogers, S. Povey, S.L. Naylor, J.C. Murray, and J.-C. Kaplan

Subjects
Botany, Genetics, Zoology, Biology, Molecular Biology, Genetics (clinical)
Published
1989
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20. Abstracts of workshop presentations pp. 948-967

Author

F.H. Ruddle, B.S. Emanuel, S. Povey, M.A. Pericak-Vance, D. Ryan, S.L. Naylor, K. Kubzdela, M.E. Hawley, T.A. Donlon, D.W. Cox, C. Park, D.F. Barker, Y. Kaneko, R.L. Miller, M.L. Cavanaugh, M. Smith, B. Keats, D.C. Wallace, Kenneth K. Kidd, A. Bale, N. Creau-Goldberg, M.L. Mador, A.M. Bowcock, W.P. Alles, G.R. Sutherland, J.-L. Mandel, J. Ott, E. Solomon, A.L. Hillyard, T.B. Shows, M. Conneally, T.G. Berent, J.C. Murray, J.-C. Kaplan, G. Romeo, M.A. FergusonSmith, P. Cartwright, P.J. McAlpine, D.P. Doolittle, J.M. Trent, F. Mitelman, P.N. Goodfellow, S.J. O'Brien, J.A. Rogers, H.-H. Ropers, M.A. Spence, P.A. Lalley, D.T. Bishop, N.E. Simpson, J. Frézal, T.H. Roderick, J.M. Puck, J. Gelernter, K.D. Smith, K.K. Kidd, P. Pearson, R.L. Nussbaum, O.W. McBride, S.T. Reeders, H. Donis-Keller, D.H. Ledbetter, B. Carritt, R.C. Douté, K.E. Davies, A. Schinzel, M M Le Beau, L.L. Field, F. Lewitter, C.E. Hildebrand, F. Ricciuti, M.T. Davisson, L.C. Stranc, R.E. Ferrell, C. Junien, L.-C. Tsui, I.W. Craig, J.E. Womack, K.H. Buetow, G.L. Schiff, G. Hutchings, C.T. Falk, H.F. Willard, C. Boucheix, J. Schmidtke, R.K. Track, P.S. Harper, M. Litt, H.S. Chan, N.K. Spurr, Frank H. Ruddle, J. Weissenbach, M. Farrall, J.A.M. Graves, J.J. Wasmuth, L. Giuffra, S.L. Sherman, D.R. Cox, A.J. Pakstis, and G.A.P Bruns

Subjects
Genetics, Library science, Computational biology, Biology, Molecular Biology, Genetics (clinical)
Published
1989
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21. Abstracts of workshop presentations (Part 3 of 16)

Author

T. Gedde-Dahl, S.J. O'Brien, M. Fellous, J.C. Kaplan, A.Y. Sakaguchi, J.J. Wasmuth, P.L. Pearson, B. Olaisen, H.H. Kazazian, J.M. Trent, Lap-Chee Tsui, D.W. Cox, J. Weissenbach, H. Van den Berghe, H.H. Ropers, C. Junien, Hans Eiberg, P.M. Conneally, B.J.B. Keats, Anne Spence, N. Créau-Goldberg, B. Carritt, Jean Frézal, J.M. Lalouel, P.J. McAlpine, J.F. Gusella, J.M. Graves, Duncan Shaw, H.F. Willard, G.R. Sutherland, Pierre Maroteaux, T.H. Roderick, Kenneth K. Kidd, J.E. Womack, C.D. Bloomfield, D.P. Doolittle, G.A. Bruns, N.E. Morton, J.F. Mattei, C. Boucheix, Victor A. McKusick, G. Echard, P.A. Lalley, S.L. Naylor, J.N. Guidi, R.C. Doute, A.J. Pakstis, N. Van Cong, T.B. Shows, M.T. Davisson, K.E. Davies, and J.-L. Mandel

Subjects
Genetics, Library science, Biology, Molecular Biology, Genetics (clinical)
Published
1987
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22. Abstracts of workshop presentations (Part 8 of 16)

Author

Lap-Chee Tsui, J.F. Mattei, J. Weissenbach, H.H. Kazazian, G.A. Bruns, T. Gedde-Dahl, J.J. Wasmuth, J.M. Lalouel, H.H. Ropers, P.L. Pearson, N.E. Morton, J.N. Guidi, Victor A. McKusick, G. Echard, H. Van den Berghe, J.M. Trent, P.J. McAlpine, J.F. Gusella, R.C. Doute, A.Y. Sakaguchi, P.A. Lalley, J.C. Kaplan, Kenneth K. Kidd, C.D. Bloomfield, N. Van Cong, D.P. Doolittle, J.E. Womack, S.J. O'Brien, M.T. Davisson, M. Fellous, Hans Eiberg, Duncan Shaw, B.J.B. Keats, S.L. Naylor, C. Boucheix, K.E. Davies, J.-L. Mandel, T.H. Roderick, T.B. Shows, G.R. Sutherland, A.J. Pakstis, P.M. Conneally, Pierre Maroteaux, N. Créau-Goldberg, D.W. Cox, B. Olaisen, C. Junien, Anne Spence, B. Carritt, Jean Frézal, J.M. Graves, and H.F. Willard

Subjects
Genetics, Computational biology, Biology, Molecular Biology, Data science, Genetics (clinical)
Published
1987
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23. Abstracts of workshop presentations (Part 2 of 16)

Author

J. Weissenbach, Victor A. McKusick, Kenneth K. Kidd, N.E. Morton, J.F. Mattei, H.F. Willard, J.E. Womack, G. Echard, J.M. Trent, P.A. Lalley, G.R. Sutherland, H.H. Kazazian, C. Junien, Anne Spence, J.M. Lalouel, B. Carritt, Jean Frézal, A.J. Pakstis, J.M. Graves, D.P. Doolittle, C. Boucheix, P.L. Pearson, M.T. Davisson, T. Gedde-Dahl, B.J.B. Keats, C.D. Bloomfield, S.J. O'Brien, A.Y. Sakaguchi, G.A. Bruns, P.J. McAlpine, J.F. Gusella, J.J. Wasmuth, Lap-Chee Tsui, M. Fellous, Hans Eiberg, N. Créau-Goldberg, J.N. Guidi, K.E. Davies, J.-L. Mandel, R.C. Doute, H.H. Ropers, B. Olaisen, S.L. Naylor, H. Van den Berghe, N. Van Cong, T.B. Shows, J.C. Kaplan, D.W. Cox, P.M. Conneally, Duncan Shaw, Pierre Maroteaux, and T.H. Roderick

Subjects
Genetics, Computational biology, Biology, Molecular Biology, Data science, Genetics (clinical)
Published
1987
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24. Abstracts of workshop presentations (Part 5 of 16)

Author

A.J. Pakstis, N.E. Morton, G. Echard, P.J. McAlpine, J.F. Gusella, H.H. Kazazian, H.F. Willard, C. Junien, D.P. Doolittle, M.T. Davisson, N. Van Cong, S.L. Naylor, Lap-Chee Tsui, G.A. Bruns, Anne Spence, S.J. O'Brien, J.M. Lalouel, K.E. Davies, Pierre Maroteaux, N. Créau-Goldberg, J.N. Guidi, M. Fellous, J.-L. Mandel, A.Y. Sakaguchi, J.F. Mattei, C. Boucheix, T.B. Shows, B. Olaisen, B. Carritt, Jean Frézal, R.C. Doute, T. Gedde-Dahl, J.M. Graves, J. Weissenbach, J.C. Kaplan, Duncan Shaw, Kenneth K. Kidd, J.J. Wasmuth, H.H. Ropers, G.R. Sutherland, C.D. Bloomfield, T.H. Roderick, J.E. Womack, Hans Eiberg, H. Van den Berghe, Victor A. McKusick, P.A. Lalley, P.M. Conneally, P.L. Pearson, J.M. Trent, D.W. Cox, and B.J.B. Keats

Subjects
Genetics, Computational biology, Biology, Molecular Biology, Data science, Genetics (clinical)
Published
1987
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25. Index by Keyword

Author

A.L. Hillyard, P.J. McAlpine, D.W. Cox, S. Povey, R.L. Nussbaum, S.L. Naylor, A. Bale, E. Solomon, G. Romeo, F. Ricciuti, D.F. Barker, P.N. Goodfellow, J.A. Rogers, L.L. Field, M.A. Spence, Frank H. Ruddle, H. Donis-Keller, C.E. Hildebrand, K. Kubzdela, M.E. Hawley, T.A. Donlon, T.G. Berent, B.S. Emanuel, M.T. Davisson, O.W. McBride, Kenneth K. Kidd, A.J. Pakstis, S.T. Reeders, R.C. Douté, M M Le Beau, C. Junien, M. Conneally, C. Park, M.A. Pericak-Vance, G.A.P Bruns, L.-C. Tsui, J.J. Wasmuth, N. Creau-Goldberg, M.L. Cavanaugh, L. Giuffra, F. Mitelman, D.C. Wallace, M. Smith, B. Keats, J. Frézal, J. Gelernter, P. Cartwright, R.E. Ferrell, M.A. FergusonSmith, K.D. Smith, S.J. O'Brien, G.L. Schiff, M.L. Mador, N.E. Simpson, Y. Kaneko, G. Hutchings, D.H. Ledbetter, T.H. Roderick, D.T. Bishop, J.M. Trent, B. Carritt, L.C. Stranc, D.P. Doolittle, J.M. Puck, K.K. Kidd, F.H. Ruddle, H.F. Willard, J.E. Womack, J.-L. Mandel, K.E. Davies, A. Schinzel, R.K. Track, S.L. Sherman, C. Boucheix, A.M. Bowcock, D. Ryan, G.R. Sutherland, R.L. Miller, T.B. Shows, P.S. Harper, M. Litt, N.K. Spurr, D.R. Cox, H.-H. Ropers, P. Pearson, F. Lewitter, K.H. Buetow, I.W. Craig, J. Weissenbach, M. Farrall, J. Ott, J.A.M. Graves, P.A. Lalley, J.C. Murray, J.-C. Kaplan, H.S. Chan, C.T. Falk, J. Schmidtke, and W.P. Alles

Subjects
Index (economics), Statistics, Genetics, Biology, Bioinformatics, Molecular Biology, Genetics (clinical)
Published
1989
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26. Abstracts of workshop presentations (Part 13 of 16)

Author

Victor A. McKusick, B.J.B. Keats, P.L. Pearson, H.H. Ropers, D.P. Doolittle, P.A. Lalley, J.N. Guidi, Pierre Maroteaux, M.T. Davisson, R.C. Doute, C.D. Bloomfield, K.E. Davies, Lap-Chee Tsui, C. Junien, J.-L. Mandel, G.R. Sutherland, P.M. Conneally, A.J. Pakstis, Anne Spence, T.B. Shows, G.A. Bruns, N. Van Cong, B. Carritt, Jean Frézal, J.C. Kaplan, P.J. McAlpine, J.F. Gusella, J.M. Graves, Kenneth K. Kidd, S.L. Naylor, A.Y. Sakaguchi, C. Boucheix, J.E. Womack, D.W. Cox, N. Créau-Goldberg, Hans Eiberg, H.F. Willard, J. Weissenbach, H. Van den Berghe, Duncan Shaw, B. Olaisen, T.H. Roderick, J.M. Lalouel, G. Echard, N.E. Morton, S.J. O'Brien, M. Fellous, H.H. Kazazian, T. Gedde-Dahl, J.F. Mattei, J.J. Wasmuth, and J.M. Trent

Subjects
Genetics, Library science, Biology, Molecular Biology, Genetics (clinical)
Published
1987
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27. Abstracts of workshop presentations (Part 7 of 16)

Author

Duncan Shaw, T.H. Roderick, J.M. Lalouel, N. Van Cong, H.H. Kazazian, H.H. Ropers, Victor A. McKusick, C. Junien, Anne Spence, P.A. Lalley, H.F. Willard, N.E. Morton, A.J. Pakstis, B. Carritt, Jean Frézal, J.M. Graves, C.D. Bloomfield, G.A. Bruns, P.L. Pearson, T. Gedde-Dahl, P.M. Conneally, J.M. Trent, J.F. Mattei, B. Olaisen, Kenneth K. Kidd, S.L. Naylor, J.J. Wasmuth, J. Weissenbach, Lap-Chee Tsui, J.E. Womack, C. Boucheix, D.P. Doolittle, J.N. Guidi, D.W. Cox, N. Créau-Goldberg, G.R. Sutherland, M.T. Davisson, R.C. Doute, K.E. Davies, J.-L. Mandel, T.B. Shows, H. Van den Berghe, J.C. Kaplan, B.J.B. Keats, A.Y. Sakaguchi, P.J. McAlpine, J.F. Gusella, Hans Eiberg, Pierre Maroteaux, S.J. O'Brien, M. Fellous, and G. Echard

Subjects
Genetics, Library science, Biology, Molecular Biology, Genetics (clinical)
Published
1987
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28. Abstracts of workshop presentations pp. 1006-1022

Author

A.M. Bowcock, H. Donis-Keller, G.R. Sutherland, J. Weissenbach, P. Pearson, M. Farrall, J.J. Wasmuth, A.J. Pakstis, L. Giuffra, D.W. Cox, F. Lewitter, Frank H. Ruddle, G.A.P Bruns, S. Povey, J.A.M. Graves, S.L. Naylor, M.A. Spence, J.A. Rogers, D.F. Barker, D.C. Wallace, D.R. Cox, J.C. Murray, J.-C. Kaplan, R.K. Track, N.E. Simpson, A.L. Hillyard, C.T. Falk, K.H. Buetow, P. Cartwright, M.A. Pericak-Vance, P.J. McAlpine, Kenneth K. Kidd, M. Smith, B. Keats, S.J. O'Brien, B.S. Emanuel, J. Ott, L.L. Field, H.-H. Ropers, Y. Kaneko, N. Creau-Goldberg, A. Bale, E. Solomon, J.M. Trent, C.E. Hildebrand, F. Ricciuti, H.F. Willard, G. Romeo, M.T. Davisson, C. Boucheix, P.N. Goodfellow, C. Junien, J.E. Womack, K. Kubzdela, M.E. Hawley, T.A. Donlon, S.L. Sherman, L.-C. Tsui, J. Schmidtke, D.H. Ledbetter, P.A. Lalley, D.T. Bishop, M. Conneally, B. Carritt, M.L. Cavanaugh, O.W. McBride, S.T. Reeders, R.C. Douté, P.S. Harper, W.P. Alles, M. Litt, M.A. FergusonSmith, M M Le Beau, H.S. Chan, N.K. Spurr, K.E. Davies, A. Schinzel, G.L. Schiff, T.G. Berent, R.E. Ferrell, J. Frézal, G. Hutchings, J. Gelernter, I.W. Craig, K.D. Smith, J.M. Puck, K.K. Kidd, C. Park, R.L. Nussbaum, L.C. Stranc, T.B. Shows, T.H. Roderick, F.H. Ruddle, D. Ryan, R.L. Miller, M.L. Mador, D.P. Doolittle, F. Mitelman, and J.-L. Mandel

Subjects
Genetics, Library science, Biology, Molecular Biology, Genetics (clinical)
Published
1989
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29. Abstracts of workshop presentations (Part 6 of 16)

Author

N. Créau-Goldberg, B. Olaisen, T.B. Shows, Kenneth K. Kidd, H.F. Willard, Hans Eiberg, J.N. Guidi, C. Boucheix, S.J. O'Brien, J.M. Lalouel, H.H. Ropers, T. Gedde-Dahl, J.F. Mattei, J.C. Kaplan, M. Fellous, A.J. Pakstis, G.R. Sutherland, B.J.B. Keats, N. Van Cong, R.C. Doute, M.T. Davisson, Victor A. McKusick, P.L. Pearson, J.J. Wasmuth, Pierre Maroteaux, J.E. Womack, J.M. Trent, P.J. McAlpine, H.H. Kazazian, J.F. Gusella, P.A. Lalley, J. Weissenbach, K.E. Davies, J.-L. Mandel, Lap-Chee Tsui, Duncan Shaw, C.D. Bloomfield, N.E. Morton, T.H. Roderick, G. Echard, H. Van den Berghe, D.P. Doolittle, A.Y. Sakaguchi, G.A. Bruns, S.L. Naylor, C. Junien, Anne Spence, B. Carritt, Jean Frézal, J.M. Graves, D.W. Cox, and P.M. Conneally

Subjects
Genetics, Library science, Biology, Molecular Biology, Genetics (clinical)
Published
1987
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31. Leucocyte Malignancies

Author

R. G. Andrews, I. D. Bernstein, B. Torok-Storb, C. G. Bell, P. Biberfeld, B. Christensson, Å. Öst, R. Hast, L. Skoog, R. Andreason, L. Olsson, B. Lagerlöf, P. Reizenstein, C. Boucheix, J. Y. Perrot, M. Mirshahi, N. Fournier, M. Billard, F. Giannoni, A. Bernadou, C. Rosenfeld, J. W. Chiao, C. Y. Wang, G. S. Del Giacco, L. Cengiarotti, A. Di Tucci, G. Broccia, G. Corda, A. Mathieu, F. Indiveri, F. Locci, G. Mantovani, B. Detrick-Hooks, L. Boumsell, A. Bernard, J. J. Hooks, M. Divine, J. P. Farcet, M. F. Gourdin, A. Vasconcelos, A. Tabilio, C. Andre, J. Bouguet, F. Reyes, S. Fontan, J. M. Zabay, M. C. Garcia, D. Pascual-Salcedo, A. Campos, E. G. de la Concha, J. Gordon, P. Åman, H. Mellstedt, G. Klein, J. A. Habeshaw, F. Herrmann, G. Sieber, H. Rühl, A. M. Lebacq, A. M. Ravoet, H. Bazin, M. De Bruyere, J. Rodhain, G. Sokal, G. Losa, G. Maestroni, G. Lucivero, S. Antonaci, C. Stomeo, L. Bonomo, J. P. Magaud, J. Brochier, H. Vu Van, M. El Ansary, O. Gentilhomme, P. A. Bryon, G. Mathé, J. Minowada, C. Ogier, M. Ginsbourg, A. Goutner, W. Knapp, C. Canon, C. J. M. Melief, F. Miedema, H. C. Rümke, R. J. M. ten Berge, F. G. Terpstra, A. E. G. Kr. v.d. Borne, R. Willemze, W. v. Vloten, A. K. Miljkovic, K. Isakovic, B. D. Jankovic, R. Peng, D. M. Knowles, Y. Bushkin, G. G. Petrányi, G. Busch, E. Milford, R. Todd, J. Griffin, E. Reinherz, C. Terhorst, St. Schlossman, Ch. Carpenter, Y. Richard, F. Demeocq, R. Schwarting, J. Thoen, Ø. T. Førre, V. von Fliedner, S. Carrel, D. Heumann, P. Zaech, R. P. Sekaly, Ch. Girardet, J. P. Mach, W. Azzo, C. Worman, K. Mills, D. Brooks, N. Hogg, H. Zola, P. Beverly, and J. Cawley

Published
1984
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33. Non epidermotropic cutaneous lymphoma ending in leukemia. A case of adult T cell lymphoma (ATL) in France?

Author

J Y, Follézou, J, Audouin, M, Reynes, M, Thulliez, J, Diebold, J Y, Perrot, and C, Boucheix

Subjects
Adult, Cell Nucleus, Male, Cytoplasm, Leukemia, Rosette Formation, Skin Neoplasms, Histocompatibility Antigens Class II, HLA-DR Antigens, Neoplasms, Multiple Primary, Microscopy, Electron, Antigens, Neoplasm, Humans, France, Retroviridae Infections
Abstract

A case of uncommon non Hodgkin malignant lymphoma with initial skin involvement is reported. The pathological pattern does not come under standard classifications. An aspect of non epidermotropic diffuse pleomorphic lymphoma is observed. In an immunological cell membrane study, the T-cell lineage of the malignant proliferation exhibited a very unusual pattern including the presence of the E rosette receptor and the expression of HLA-DR monomorphic determinant. This type of T cell malignant lymphoma can probably be included in the group of adult T cell leukemia/lymphoma (ATL) which is endemic in South Western Japan and occasionally observed in Western countries. The emergence of such cases in these countries raises important epidemiological questions.

Published
1986

34. Guidelines for human gene nomenclature. An international system for human gene nomenclature (ISGN, 1987)

Author

T B, Shows, P J, McAlpine, C, Boucheix, F S, Collins, P M, Conneally, J, Frézal, H, Gershowitz, P N, Goodfellow, J G, Hall, P, Issitt, C A, Jones, B B, Knowles, M, Lewis, V A, McKusick, M, Meisler, N E, Morton, P, Rubenstein, M S, Schanfield, R D, Schmickel, M H, Skolnick, M A, Spence, G R, Sutherland, M, Traver, N, Van Cong, and H F, Willard

Subjects
Genetic Markers, Terminology as Topic, Chromosome Mapping, Humans
Published
1987

36. [Clinical applications of monoclonal antibodies]

Author

C, Boucheix

Subjects
Graft Rejection, Leukemia, Neoplasms, Antibodies, Monoclonal, Graft vs Host Disease, Humans, Immunotherapy, Lymphocytes, Autoimmune Diseases, Bone Marrow Transplantation
Published
1985

38. Index by Abstract Number

Author

F.H. Ruddle, T.B. Shows, J.E. Womack, D. Ryan, S. Povey, S.L. Naylor, W.P. Alles, A.M. Bowcock, R.L. Miller, A. Bale, E. Solomon, G.R. Sutherland, G. Romeo, T.H. Roderick, C.T. Falk, D.R. Cox, P.N. Goodfellow, P. Cartwright, S.J. O'Brien, J.-L. Mandel, M.L. Mador, L.C. Stranc, Kenneth K. Kidd, H.-H. Ropers, J. Schmidtke, J. Ott, J.M. Trent, D.P. Doolittle, M.A. Pericak-Vance, O.W. McBride, J. Weissenbach, M. Farrall, P. Pearson, A.L. Hillyard, S.T. Reeders, R.C. Douté, P.J. McAlpine, H. Donis-Keller, B.S. Emanuel, K.E. Davies, L.L. Field, M M Le Beau, F. Lewitter, A. Schinzel, F. Ricciuti, J.M. Puck, Y. Kaneko, C.E. Hildebrand, F. Mitelman, J.A.M. Graves, A.J. Pakstis, P.S. Harper, M. Litt, N.K. Spurr, M.T. Davisson, C. Junien, K.K. Kidd, L.-C. Tsui, T.G. Berent, H.S. Chan, J.J. Wasmuth, G.L. Schiff, G.A.P Bruns, P.A. Lalley, L. Giuffra, N. Creau-Goldberg, G. Hutchings, I.W. Craig, S.L. Sherman, M. Conneally, J.C. Murray, J. Frézal, J.-C. Kaplan, D.T. Bishop, K. Kubzdela, M.E. Hawley, T.A. Donlon, D.H. Ledbetter, D.C. Wallace, R.E. Ferrell, B. Carritt, J. Gelernter, M.A. FergusonSmith, K.D. Smith, M.L. Cavanaugh, D.W. Cox, H.F. Willard, M.A. Spence, C. Boucheix, R.K. Track, R.L. Nussbaum, D.F. Barker, Frank H. Ruddle, N.E. Simpson, M. Smith, B. Keats, K.H. Buetow, C. Park, and J.A. Rogers

Subjects
Index (economics), business.industry, Statistics, Genetics, Biology, business, Molecular Biology, Genetics (clinical), Biotechnology
Published
1989
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39. A note on the use of HGML LIT literature file numbers

Author

J.M. Trent, A. Bale, E. Solomon, F.H. Ruddle, G. Romeo, L.L. Field, P. Pearson, J.E. Womack, F. Lewitter, D. Ryan, I.W. Craig, T.B. Shows, G.L. Schiff, C.E. Hildebrand, P.N. Goodfellow, P. Cartwright, M.A. Spence, W.P. Alles, S.J. O'Brien, H.F. Willard, G. Hutchings, C. Boucheix, R.L. Miller, D.W. Cox, Frank H. Ruddle, A.M. Bowcock, H.-H. Ropers, F. Ricciuti, O.W. McBride, G.R. Sutherland, S.T. Reeders, D.F. Barker, M.L. Mador, M. Smith, M.T. Davisson, C. Junien, L.-C. Tsui, K.H. Buetow, R.E. Ferrell, R.C. Douté, M M Le Beau, M. Conneally, B. Keats, J.J. Wasmuth, L. Giuffra, D.P. Doolittle, T.H. Roderick, P.S. Harper, M.A. Pericak-Vance, B.S. Emanuel, M. Litt, N.K. Spurr, N.E. Simpson, H.S. Chan, A.J. Pakstis, M.L. Cavanaugh, C. Park, R.K. Track, J. Ott, Y. Kaneko, C.T. Falk, G.A.P Bruns, J. Frézal, J. Gelernter, K.D. Smith, J.-L. Mandel, P.A. Lalley, J. Schmidtke, K.E. Davies, A. Schinzel, A.L. Hillyard, N. Creau-Goldberg, P.J. McAlpine, S.L. Sherman, D.H. Ledbetter, F. Mitelman, M.A. FergusonSmith, B. Carritt, J. Weissenbach, M. Farrall, J.A.M. Graves, T.G. Berent, D.R. Cox, R.L. Nussbaum, L.C. Stranc, D.C. Wallace, H. Donis-Keller, Kenneth K. Kidd, J.A. Rogers, D.T. Bishop, S. Povey, S.L. Naylor, J.M. Puck, K.K. Kidd, K. Kubzdela, M.E. Hawley, T.A. Donlon, J.C. Murray, and J.-C. Kaplan

Subjects
Information retrieval, Genetics, Biology, Bioinformatics, Molecular Biology, Genetics (clinical)
Published
1989
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40. Summary of Human Gene Map, New Haven, HGM – 1, 1973, ‘Data 1'

Author

J.C. Murray, J.-C. Kaplan, K. Kubzdela, M.E. Hawley, T.A. Donlon, J. Weissenbach, M. Farrall, F. Ricciuti, M.T. Davisson, T.G. Berent, M.A. Spence, C. Junien, L.-C. Tsui, J.A.M. Graves, A.L. Hillyard, P.J. McAlpine, Frank H. Ruddle, P. Pearson, S. Povey, D.R. Cox, J.A. Rogers, F. Lewitter, W.P. Alles, D.W. Cox, P. Cartwright, S.J. O'Brien, S.L. Naylor, K.E. Davies, A. Schinzel, L.L. Field, F.H. Ruddle, A.M. Bowcock, C.E. Hildebrand, G.L. Schiff, G.R. Sutherland, D.C. Wallace, D. Ryan, R.E. Ferrell, J.J. Wasmuth, L. Giuffra, G. Hutchings, D.F. Barker, C. Park, J.M. Trent, H.-H. Ropers, H. Donis-Keller, D.T. Bishop, H.S. Chan, S.L. Sherman, M. Conneally, J.E. Womack, N.E. Simpson, J. Frézal, Kenneth K. Kidd, R.L. Miller, B.S. Emanuel, J.M. Puck, L.C. Stranc, K.K. Kidd, J. Gelernter, K.D. Smith, M.L. Cavanaugh, A.J. Pakstis, M.A. Pericak-Vance, M.L. Mador, R.K. Track, D.H. Ledbetter, B. Carritt, G.A.P Bruns, M. Smith, B. Keats, D.P. Doolittle, Y. Kaneko, C.T. Falk, J. Schmidtke, K.H. Buetow, O.W. McBride, P.S. Harper, S.T. Reeders, M. Litt, N.K. Spurr, R.C. Douté, M M Le Beau, H.F. Willard, C. Boucheix, A. Bale, E. Solomon, I.W. Craig, G. Romeo, P.N. Goodfellow, J. Ott, P.A. Lalley, N. Creau-Goldberg, M.A. FergusonSmith, R.L. Nussbaum, F. Mitelman, J.-L. Mandel, T.B. Shows, and T.H. Roderick

Subjects
Genetics, Gene map, Computational biology, Biology, Molecular Biology, Genetics (clinical), Haven
Published
1989
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41. Guidelines for interpreting abbreviations and specialized phrases in committee text and tables

Author

K. Kubzdela, M.E. Hawley, T.A. Donlon, I.W. Craig, B.S. Emanuel, N.E. Simpson, A.M. Bowcock, G.R. Sutherland, J.M. Puck, J.E. Womack, C. Park, K.K. Kidd, J.A. Rogers, W.P. Alles, H.S. Chan, J.J. Wasmuth, J. Frézal, J. Weissenbach, M.A. Pericak-Vance, P.S. Harper, L. Giuffra, M. Farrall, M.L. Mador, A.J. Pakstis, J. Gelernter, K.D. Smith, H. Donis-Keller, J. Ott, L.L. Field, R.K. Track, D.P. Doolittle, G.A.P Bruns, C.E. Hildebrand, Y. Kaneko, M. Litt, N.K. Spurr, O.W. McBride, T.H. Roderick, T.B. Shows, R.E. Ferrell, J.M. Trent, D.H. Ledbetter, F.H. Ruddle, B. Carritt, S.T. Reeders, R.C. Douté, P.A. Lalley, M M Le Beau, D. Ryan, C.T. Falk, J.A.M. Graves, M. Conneally, K.E. Davies, A. Schinzel, D.R. Cox, P. Pearson, Frank H. Ruddle, R.L. Miller, G.L. Schiff, F. Lewitter, F. Ricciuti, J. Schmidtke, T.G. Berent, H.F. Willard, J.C. Murray, J.-C. Kaplan, C. Boucheix, A. Bale, E. Solomon, M.T. Davisson, G. Hutchings, G. Romeo, C. Junien, P.N. Goodfellow, L.-C. Tsui, A.L. Hillyard, P.J. McAlpine, P. Cartwright, S.J. O'Brien, M.A. Spence, M.L. Cavanaugh, S.L. Sherman, D.W. Cox, D.C. Wallace, L.C. Stranc, K.H. Buetow, D.F. Barker, D.T. Bishop, H.-H. Ropers, M. Smith, B. Keats, S. Povey, S.L. Naylor, Kenneth K. Kidd, R.L. Nussbaum, N. Creau-Goldberg, M.A. FergusonSmith, J.-L. Mandel, and F. Mitelman

Subjects
Genetics, Biology, Molecular Biology, Genetics (clinical), Linguistics
Published
1989
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42. The Tetraspanin Tspan8 Associates with Endothelin Converting Enzyme ECE1 and Regulates Its Activity.

Author

Zhu Y, Saint-Pol J, Nguyen V, Rubinstein E, Boucheix C, and Greco C

Abstract

Tspan8 is a member of the tetraspanins family of cell surface molecules. The ability of tetraspanins to organize membrane microdomains with other membrane molecules and interfere with their function suggests that they could act as surface integrators of external or internal signals. Among the first identified tetraspanins, Tspan8 promotes tumor progression and metastasis, presumably by stimulating angiogenesis and cell motility. In patients, its expression on digestive tract tumors seems to be associated with a bad prognosis. We showed previously that Tspan8 associates with E-cadherin and EGFR and modulates their effects on cell motility. Using Mass spectrometry and western blot, we found a new partner, the endothelin converting enzyme ECE1, and showed that Tspan8 amplifies its activity of conversion of the endothelin-1 precursor bigET1 to endothelin. This was observed by transduction of the colon carcinoma cell line Isreco1, which does not express Tspan8, and on ileum tissue fragments of tspan8ko mice versus wild type mice. Given these results, Tspan8 appears to be a modulator of the endothelin axis, which could possibly be targeted in case of over-activity of endothelins in biological processes of tissues expressing Tspan8.

Published
2023
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43. Pharmacologic modulation of 5-fluorouracil by folinic acid and pyridoxine for treatment of patients with advanced breast carcinoma.

Author

Machover D, Goldschmidt E, Almohamad W, Castagné V, Dairou J, Desterke C, Gomez L, Gaston-Mathé Y, and Boucheix C

Subjects
Antineoplastic Combined Chemotherapy Protocols, Doxorubicin, Female, Humans, Pilot Projects, Breast Neoplasms pathology, Fluorouracil therapeutic use, Leucovorin therapeutic use, Pyridoxine therapeutic use
Abstract

High concentration pyridoxal 5'-phosphate, the cofactor of vitamin B6, potentiates cytotoxicity in cancer cells exposed to 5-fluorouracil (FUra) and folinic acid (FA). We studied the effect of high-dose pyridoxine on antitumor activity of regimens comprising FUra and FA in 27 advanced breast carcinoma patients. Of 18 previously untreated patients, 12 had tumors that did not overexpress HER2 (Group I), and 6 that overexpressed HER2 (Group II). Nine patients (Group III) had prior chemotherapy. Group I received AVCF (doxorubicin, vinorelbine, cyclophosphamide, FUra, FA) or FAC (doxorubicin, cyclophosphamide, FUra, FA) followed by TCbF (paclitaxel carboplatin, FUra, FA). Groups II, and III received TCbF. Pyridoxine iv (1000-3000 mg/day) preceded each FA and FUra. Group II also received trastuzumab and pertuzumab. 26 patients responded. Three patients in Group I had CRs and 9 had PRs with 62-98% reduction rates; 4 patients in Group II had CRs and 2 had PRs with 98% reduction. Of 7 measurable patients in Group III, 2 attained CRs, and 5 had PRs with 81-94% reduction rates. Median time to response was 3.4 months. Unexpected toxicity did not occur. This pilot study suggests that high-dose vitamin B6 enhances antitumor potency of regimens comprising FUra and FA., (© 2022. The Author(s).)

Published
2022
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44. Treatment of Painful Palmoplantar Keratoderma Related to Pachyonychia Congenita Using EGFR Inhibitors.

Author

Greco C, Ponsen AC, Leclerc-Mercier S, Schlatter J, Cisternino S, Boucheix C, and Bodemer C

Abstract

Pachyonychia congenita (PC) is a genodermatosis associated with severe painful palmoplantar keratoderma (PPK) and thickened dystrophic nails caused by autosomal dominant-negative mutations in five genes encoding keratins 6A-B-C, 16, and 17. The mechanical, surgical, or medical options for painful PC are inefficient. Given ErbB/Her family members' role in epidermal homeostasis, this study sought to investigate the possibility of treating PC patients with PPK by blocking signaling either with EGFR (Her1) inhibitor erlotinib or lapatinib, a dual EGFR(Her1)/Her2. After 1 month of therapy with oral erlotinib treatment at 75 mg/day, the pain disappeared for patient #1, with partially reduced hyperkeratosis, while increasing the dose to 100 mg/day resulted in painful skin fissures. Therapy replacement with erlotinib cream at 0.2% was inconclusive, and substitution with oral lapatinib at alternating doses of 500 and 750 mg/day achieved a good compromise between pain reduction, symptom improvements, and side effects. Patient #2's treatment with erlotinib cream failed to display significant improvements. Oral erlotinib started at 75 mg/day then reduced to 25 mg/day because of the formation of an acneiform rash. Treatment considerably improved the patient's condition, with an almost complete disappearance of pain. Oral Her1 or 1/2 inhibitors reduced pain, improved two PC patients' quality of life, and offered promising therapeutic perspectives.

Published
2022
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45. Pharmacologic modulation of 5-fluorouracil by folinic acid and high-dose pyridoxine for treatment of patients with digestive tract carcinomas.

Author

Machover D, Almohamad W, Castagné V, Desterke C, Gomez L, Gaston-Mathé Y, Boucheix C, and Goldschmidt E

Subjects
Adenocarcinoma drug therapy, Adult, Aged, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Colorectal Neoplasms drug therapy, Drug Combinations, Female, Fluorouracil therapeutic use, Gastrointestinal Tract pathology, Humans, Leucovorin therapeutic use, Male, Middle Aged, Pilot Projects, Pyridoxine therapeutic use, Gastrointestinal Neoplasms drug therapy, Vitamin B Complex therapeutic use
Abstract

Supplementation of cancer cells exposed to 5-fluorouracil (FUra) and folinic acid (FA) with high concentration pyridoxal 5'-phosphate, the cofactor of vitamin B6, potentiates the cytotoxicity of FUra in a synergistic interaction mode. We report a pilot study in 13 patients with previously untreated advanced carcinoma of the digestive tract to assess the impact of high-dose pyridoxine (PN) on the antitumor activity of regimens comprising FUra and FA. Five patients had colorectal adenocarcinoma (CRC); 5 had pancreas adenocarcinoma (PC); and 3 had squamous cell carcinoma of the esophagus (EC). Patients with CRC and with PC received oxaliplatin, irinotecan, FUra and FA, and patients with EC had paclitaxel, carboplatin, FUra and FA. PN iv from 1000 to 3000 mg/day preceded each administration of FA and FUra. Eleven patients responded. Two patients with CRC attained CRs and 3 had PRs with reduction rates ≥ 78%. Two patients with PC attained CRs, and 2 had PRs with reduction rates ≥ 79%. Responders experienced disappearance of most metastases. Of 3 patients with EC, 2 attained CRs. Median time to attain a response was 3 months. Unexpected toxicity did not occur. Results suggest that high-dose vitamin B6 enhances antitumor potency of regimens comprising FUra and FA.

Published
2021
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46. Endothelin-1 Exhibiting Pro-Nociceptive and Pro-Peristaltic Activities Is Increased in Peritoneal Carcinomatosis.

Author

Greco C, Basso L, Désormeaux C, Fournel A, Demuynck B, Lafendi L, Chapiro S, Lemoine A, Zhu YY, Knauf C, Cenac N, Boucheix C, and Dietrich G

Abstract

Background: Peritoneal carcinomatosis often results in alterations in intestinal peristalsis and recurrent abdominal pain. Pain management in these patients is often unsatisfactory. This study aimed to investigate whether endothelin-1 (EDN1) was involved in pain mediation in peritoneal carcinomatosis, and thus whether the EDN1 pathway could be a new therapeutic target for peritoneal carcinomatosis-associated pain. Methods: EDN1 plasma levels and abdominal pain severity were assessed in patients with abdominal tumors, with or without peritoneal carcinomatosis, and in healthy donors. The effects of EDN1 on the visceromotor response to colorectal distension, and on colonic contractions were then examined in mice, and the mechanism of action of EDN1 was then investigated by measuring the impact of EDN1 exposure on calcium mobilization in cultured neurons. Inhibition studies were also performed to determine if the effects of EDN1 exposure could be reversed by EDN1-specific receptor antagonists. Results: A positive correlation between EDN1 plasma levels and abdominal pain was identified in patients with peritoneal carcinomatosis. EDN1 exposure increased visceral sensitivity and the amplitude of colonic contractions in mice and induced calcium mobilization by direct binding to its receptors on sensory neurons. The effects of EDN1 were inhibited by antagonists of the EDN1 receptors. Conclusions: This preliminary study, using data from patients with peritoneal carcinomatosis combined with data from experiments performed in mice, suggests that EDN1 may play a key role mediating pain in peritoneal carcinomatosis. Our findings suggest that antagonists of the EDN1 receptors might be beneficial in the management of pain in patients with peritoneal carcinomatosis., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Greco, Basso, Désormeaux, Fournel, Demuynck, Lafendi, Chapiro, Lemoine, Zhu, Knauf, Cenac, Boucheix and Dietrich.)

Published
2021
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47. [De novo expression of tetraspanin CD9 in parietal epithelial cells promotes extracapillary glomerulonephritis].

Author

Lazareth H, Lenoir O, Hénique C, Bouzigues C, Boucheix C, and Tharaux PL

Subjects
Animals, Disease Models, Animal, Glomerulonephritis metabolism, Glomerulonephritis pathology, Humans, Mice, Mice, Transgenic, Tetraspanin 29 metabolism, Epithelial Cells metabolism, Glomerulonephritis genetics, Kidney Glomerulus metabolism, Tetraspanin 29 genetics
Published
2020
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48. Optimization of IEDDA bioorthogonal system: Efficient process to improve trans-cyclooctene/tetrazine interaction.

Author

Béquignat JB, Ty N, Rondon A, Taiariol L, Degoul F, Canitrot D, Quintana M, Navarro-Teulon I, Miot-Noirault E, Boucheix C, Chezal JM, and Moreau E

Subjects
Cycloaddition Reaction, Isomerism, Polyethylene Glycols chemistry, Cyclooctanes chemistry, Heterocyclic Compounds, 1-Ring chemistry
Abstract

The antibody pretargeting approach for radioimmunotherapy (RIT) using inverse electron demand Diels-Alder cycloaddition (IEDDA) constitutes an emerging theranostic approach for solid cancers. However, IEDDA pretargeting has not reached clinical trial. The major limitation of the IEDDA strategy depends largely on trans-cyclooctene (TCO) stability. Indeed, TCO may isomerize into the more stable but unreactive cis-cyclooctene (CCO), leading to a drastic decrease of IEDDA efficiency. We have thus developed both efficient and reproducible synthetic pathways and analytical follow up for (PEGylated) TCO derivatives, providing high TCO isomeric purity for antibody modification. We have set up an original process to limit the isomerization of TCO to CCO before the mAbs' functionalization to allow high TCO/tetrazine cycloaddition., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 Elsevier Masson SAS. All rights reserved.)

Published
2020
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49. Rapid Isolation of Rare Isotype-Switched Hybridoma Variants: Application to the Generation of IgG2a and IgG2b MAb to CD63, a Late Endosome and Exosome Marker.

Author

Charrin S, Palmulli R, Billard M, Clay D, Boucheix C, Van Niel G, and Rubinstein E

Abstract

CD63, a member of the tetraspanin superfamily, is used as a marker of late endosomes and lysosome-related organelles, as well as a marker of exosomes. Here, we selected rare isotype variants of TS63 by sorting hybridoma cells on the basis of their high expression of surface immunoglobulins of the IgG2a and IgG2b subclass. Pure populations of cells secreting IgG2a and IgG2b variants of TS63 (referred to as TS63a and TS63b) were obtained using two rounds of cell sorting and one limited dilution cloning step. We validate that these new TS63 variants are suitable for co-labeling with mAb of the IgG1 subclass directed to other molecules, using anti mouse subclass antibodies, and for the labeling of exosomes through direct binding to protein A-coated gold particles. These mAbs will be useful to study the intracellular localization of various proteins and facilitate electron microscopy analysis of CD63 localization.

Published
2020
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50. Tspan8 Drives Melanoma Dermal Invasion by Promoting ProMMP-9 Activation and Basement Membrane Proteolysis in a Keratinocyte-Dependent Manner.

Author

El Kharbili M, Cario M, Béchetoille N, Pain C, Boucheix C, Degoul F, Masse I, and Berthier-Vergnes O

Abstract

Melanoma is the most aggressive skin cancer with an extremely challenging therapy. The dermal-epidermal junction (DEJ) degradation and subsequent dermal invasion are the earliest steps of melanoma dissemination, but the mechanisms remain elusive. We previously identified Tspan8 as a key actor in melanoma invasiveness. Here, we investigated Tspan8 mechanisms of action during dermal invasion, using a validated skin-reconstruct-model that recapitulates melanoma dermal penetration through an authentic DEJ. We demonstrate that Tspan8 is sufficient to induce melanoma cells' translocation to the dermis. Mechanistically, Tspan8 + melanoma cells cooperate with surrounding keratinocytes within the epidermis to promote keratinocyte-originated proMMP-9 activation process, collagen IV degradation and dermal colonization. This concurs with elevated active MMP-3 and low TIMP-1 levels, known to promote MMP-9 activity. Finally, a specific Tspan8-antibody reduces proMMP-9 activation and dermal invasion. Overall, our results provide new insights into the role of keratinocytes in melanoma dermal colonization through a cooperative mechanism never reported before, and establish for the first time the pro-invasive role of a tetraspanin family member in a cell non-autonomous manner. This work also displays solid arguments for the use of Tspan8-blocking antibodies to impede early melanoma spreading and therefore metastasis.

Published
2020
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