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8 results on '"C. A. Venetis"'

1. What is the optimal GnRH antagonist protocol for ovarian stimulation during ART treatment? A systematic review and network meta-analysis

Author

C A Venetis, A Storr, S J Chua, B W Mol, S Longobardi, X Yin, and T D’Hooghe

Subjects
AGONIST PROTOCOL, Reproductive Biology, Science & Technology, assisted reproductive technologies, FOLLICULAR-GROWTH, IVF CYCLES, CETRORELIX ACETATE, Obstetrics & Gynecology, Obstetrics and Gynecology, controlled ovarian stimulation, live birth, ORAL-CONTRACEPTIVE PRETREATMENT, PREGNANCY RATES, cetrorelix, LONG PROTOCOL, Reproductive Medicine, ganirelix, POOR-RESPONDER PATIENTS, GnRH antagonist, pregnancy, HORMONE ANTAGONIST, IN-VITRO FERTILIZATION, Life Sciences & Biomedicine, ART
Abstract

BACKGROUND Several GnRH antagonist protocols are currently used during COS in the context of ART treatments; however, questions remain regarding whether these protocols are comparable in terms of efficacy and safety. OBJECTIVE AND RATIONALE A systematic review followed by a pairwise and network meta-analyses were performed. The systematic review and pairwise meta-analysis of direct comparative data according to the PRISMA guidelines evaluated the effectiveness of different GnRH antagonist protocols (fixed Day 5/6 versus flexible, ganirelix versus cetrorelix, with or without hormonal pretreatment) on the probability of live birth and ongoing pregnancy after COS during ART treatment. A frequentist network meta-analysis combining direct and indirect comparisons (using the long GnRH agonist protocol as the comparator) was also performed to enhance the precision of the estimates. SEARCH METHODS The systematic literature search was performed using Embase (Ovid), MEDLINE (Ovid), Cochrane Central Register of Trials (CENTRAL), SCOPUS and Web of Science (WOS), from inception until 23 November 2021. The search terms comprised three different MeSH terms that should be present in the identified studies: GnRH antagonist; assisted reproduction treatment; randomized controlled trial (RCT). Only studies published in English were included. OUTCOMES The search strategy resulted in 6738 individual publications, of which 102 were included in the systematic review (corresponding to 75 unique studies) and 73 were included in the meta-analysis. Most studies were of low quality. One study compared a flexible protocol with a fixed Day 5 protocol and the remaining RCTs with a fixed Day 6 protocol. There was a lack of data regarding live birth when comparing the flexible and fixed GnRH antagonist protocols or cetrorelix and ganirelix. No significant difference in live birth rate was observed between the different pretreatment regimens versus no pretreatment or between the different pretreatment protocols. A flexible GnRH antagonist protocol resulted in a significantly lower OPR compared with a fixed Day 5/6 protocol (relative risk (RR) 0.76, 95% CI 0.62 to 0.94, I2 = 0%; 6 RCTs; n = 907 participants; low certainty evidence). There were insufficient data for a comparison of cetrorelix and ganirelix for OPR. OCP pretreatment was associated with a lower OPR compared with no pretreatment intervention (RR 0.79, 95% CI 0.69 to 0.92; I2 = 0%; 5 RCTs, n = 1318 participants; low certainty evidence). Furthermore, in the network meta-analysis, a fixed protocol with OCP resulted in a significantly lower OPR than a fixed protocol with no pretreatment (RR 0.84, 95% CI 0.71 to 0.99; moderate quality evidence). The surface under the cumulative ranking (SUCRA) scores suggested that the fixed protocol with no pretreatment is the antagonist protocol most likely (84%) to result in the highest OPR. There was insufficient evidence of a difference between fixed/flexible or OCP pretreatment/no pretreatment interventions regarding other outcomes, such as ovarian hyperstimulation syndrome and miscarriage rates. WIDER IMPLICATIONS Available evidence, mostly of low quality and certainty, suggests that different antagonist protocols should not be considered as equivalent for clinical decision-making. More trials are required to assess the comparative effectiveness of ganirelix versus cetrorelix, the effect of different pretreatment interventions (e.g. progestins or oestradiol) or the effect of different criteria for initiation of the antagonist in the flexible protocol. Furthermore, more studies are required examining the optimal GnRH antagonist protocol in women with high or low response to ovarian stimulation.

Published
2023
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2. Parity: A key measure of confounding in data-linkage studies of outcomes after medically assisted reproduction

Author

G M, Chambers, C A, Venetis, L R, Jorm, E P, Stavrou, and C M, Vajdic

Subjects
education.field_of_study, Information Systems and Management, Universal health insurance, business.industry, animal diseases, Confounding, Population, Health Informatics, Rurality, lcsh:HB848-3697, lcsh:Demography. Population. Vital events, Medicine, Record Linkage Study, Medical prescription, Parity (mathematics), education, business, Data Linkage, Population Data Science, Information Systems, Demography
Abstract

Parity is a potential confounder of the association between medically assisted reproduction (MAR) and health outcomes. This concept paper describes a population-based record linkage study design for selecting MAR-unexposed women matched to the parity of MAR-exposed women, at the time of the first exposure to MAR. Women exposed to MAR were identified from claims for government subsidies for relevant procedures and prescription medicines, linked to perinatal records. Women unexposed to MAR were identified from linked perinatal and death records, matched to exposed women by age, rurality, age of first child (if any) and parity at the date of first MAR. The availability of a longitudinal, whole-of-population dataset (“population spine”) based on enrolments in Australia’s universal health insurance scheme was a critical design element. The example application examines cancer risk in women after exposure to MAR. Parity is a confounder in this setting because it is associated with MAR and hormone-sensitive cancers.

Published
2020
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3. Are singleton pregnancies after assisted reproduction technology (ART) associated with a higher risk of placental anomalies compared with non-ART singleton pregnancies? A systematic review and meta-analysis

Author

B G, Vermey, A, Buchanan, G M, Chambers, E M, Kolibianakis, J, Bosdou, M G, Chapman, and C A, Venetis

Subjects
Cohort Studies, Observational Studies as Topic, Placenta Diseases, Reproductive Techniques, Assisted, Pregnancy, Odds Ratio, Humans, Female, Risk Assessment
Abstract

Placental anomalies (placenta praevia, placental abruption, morbidly adherent placenta and cord insertion anomalies) are associated with maternal and fetal morbidity and mortality. It has been suggested these might be more prevalent in pregnancies after assisted reproduction technology (ART).To determine whether ART singleton pregnancies are associated with an increased risk of placental anomalies compared with non-ART singleton pregnancies.MEDLINE, EMBASE, CENTRAL, Web of Science and Scopus (January 2018).Cohort studies reporting placental anomalies in ART and non-ART singleton pregnancies.We report pooled odds ratios (OR) for the comparisons: (1) ART versus SC (spontaneously conceived), (2) ART versus non-ART (unspecified), (3) FET-ART (frozen-embryo transfer) versus SC, (4) ART versus non-ART (subfertile patients). Study quality was assessed using a modified Newcastle -Ottawa scale.33 low/moderate quality studies evaluated 124 215 ART and 6 054 729 non-ART singleton pregnancies. Risk of placenta praevia, placental abruption and morbidly adherent placenta was higher in ART than SC pregnancies: odds ratio (OR) (OR 3.76, 95% CI 3.09-4.59); (OR 1.87, 95% CI 1.70-2.06) and (OR 2.27, 95% CI 1.79-2.87) respectively. Risk of placenta praevia and placental abruption was higher in ART than in non-ART (subfertile patients): (OR 2.51, 95% CI 2.12-2.98) and (OR 1.61, 95% CI 1.33-1.95) respectively. Results were similar when comparing ART with unspecified non-ART pregnancies. Risk of placenta praevia was higher, but not significantly so, in FET-ART than in SC pregnancies (OR 2.42, 95% CI 0.63-9.30).Singleton ART pregnancies are associated with an increased risk of placental anomalies compared with non-ART singleton pregnancies.A review of over 6 million singleton pregnancies finds increased risk of placental anomalies after ART.

Published
2018

4. Reproductive endocrinology

Author

A. Nazzaro, A. Salerno, L. Di Iorio, G. Landino, S. Marino, E. Pastore, F. Fabregues, A. Iraola, G. Casals, M. Creus, S. Peralta, J. Penarrubia, D. Manau, S. Civico, J. Balasch, I. Lindgren, Y. L. Giwercman, E. Celik, I. Turkcuoglu, B. Ata, A. Karaer, P. Kirici, B. Berker, J. Park, J. Kim, J. Rhee, M. Krishnan, O. Rustamov, R. Russel, C. Fitzgerald, S. Roberts, S. Hapuarachi, B. K. Tan, R. S. Mathur, A. van de Vijver, C. Blockeel, M. Camus, N. Polyzos, L. Van Landuyt, H. Tournaye, N. O. Turhan, D. Hizli, Z. Kamalak, A. Kosus, N. Kosus, H. Kafali, A. Lukaszuk, M. Kunicki, J. Liss, A. Bednarowska, G. Jakiel, K. Lukaszuk, M. Lukaszuk, B. Olszak-Sokolowska, T. Wasniewski, M. Neuberg, V. Cavalcanti, C. Peluso, B. L. Lechado, E. B. Cordts, D. M. Christofolini, C. P. Barbosa, B. Bianco, C. A. Venetis, E. M. Kolibianakis, J. Bosdou, B. C. Tarlatzis, M. Onal, D. N. Gungor, M. Acet, S. Kahraman, E. Kuijper, J. Twisk, M. Caanen, T. Korsen, P. Hompes, M. Kushnir, A. Rockwood, W. Meikle, C. B. Lambalk, X. Yan, X. Dai, J. Wang, N. Zhao, Y. Cui, J. Liu, F. Yarde, A. H. E. M. Maas, A. Franx, M. J. C. Eijkemans, J. T. Drost, B. B. van Rijn, J. van Eyck, Y. T. van der Schouw, F. J. M. Broekmans, F. Martyn, B. Anglim, M. Wingfield, T. Fang, G. J. Yan, H. X. Sun, Y. L. Hu, J. Chrudimska, P. Krenkova, M. Macek, J. Teixeira da Silva, M. Cunha, J. Silva, P. Viana, A. Goncalves, N. Barros, C. Oliveira, M. Sousa, A. Barros, S. M. Nelson, S. M. Lloyd, A. McConnachie, A. Khader, R. Fleming, D. A. Lawlor, L. Thuesen, A. N. Andersen, A. Loft, J. Smitz, M. Abdel-Rahman, S. Ismail, J. Silk, M. Abdellah, A. H. Abdellah, F. Ruiz, M. Cruz, M. Piro, D. Collado, J. A. Garcia-Velasco, A. Requena, Z. Kollmann, N. A. Bersinger, B. McKinnon, S. Schneider, M. D. Mueller, M. von Wolff, A. Vaucher, B. Weiss, P. Stute, U. Marti, J. Chai, W. Y. T. Yeung, C. Y. V. Lee, W. H. R. Li, P. C. Ho, H. Y. E. Ng, S. M. Kim, S. H. Kim, B. C. Jee, S. Ku, C. S. Suh, Y. M. Choi, J. G. Kim, S. Y. Moon, J. H. Lee, S. G. Kim, Y. Y. Kim, H. J. Kim, K. H. Lee, I. H. Park, H. G. Sun, Y. I. Hwang, N. Y. Sung, M. H. Choi, S. H. Cha, C. W. Park, J. Y. Kim, K. M. Yang, I. O. Song, M. K. Koong, I. S. Kang, H. O. Kim, C. Haines, W. Y. Wong, W. S. Kong, L. P. Cheung, T. K. Choy, P. C. Leung, R. Fadini, G. Coticchio, M. M. Renzini, M. C. Guglielmo, F. Brambillasca, A. Hourvitz, D. F. Albertini, P. Novara, M. Merola, M. Dal Canto, J. A. A. Iza, J. L. DePablo, C. Anarte, A. Domingo, E. Abanto, G. Barrenetxea, R. Kato, S. Kawachiya, D. Bodri, M. Kondo, T. Matsumoto, L. G. L. Maldonado, A. S. Setti, D. P. A. F. Braga, A. Iaconelli, E. Borges, C. Iaconelli, R. C. S. Figueira, K. Kitaya, S. Taguchi, M. Funabiki, Y. Tada, T. Hayashi, Y. Nakamura, M. Snajderova, D. Zemkova, V. Lanska, L. Teslik, R. N. - Calonge, L. Ortega, A. Garcia, S. Cortes, A. Guijarro, P. C. Peregrin, M. Bellavia, M. H. Pesant, D. Wirthner, L. Portman, D. de Ziegler, D. Wunder, X. Chen, S. H. L. Chen, Y. D. Liu, T. Tao, L. J. Xu, X. L. Tian, D. S. H. Ye, Y. X. He, A. Carby, E. Barsoum, S. El-Shawarby, G. Trew, S. Lavery, N. Mishieva, N. Barkalina, I. Korneeva, T. Ivanets, A. Abubakirov, R. Chavoshinejad, G. m. Hartshorne, W. Marei, A. a. Fouladi-nashta, G. Kyrkou, E. Trakakis, C. H. Chrelias, E. Alexiou, K. Lykeridou, G. Mastorakos, N. Bersinger, H. Ferrero, R. Gomez, C. M. Garcia-Pascual, C. Simon, A. Pellicer, A. Turienzo, B. Lledo, J. Guerrero, J. A. Ortiz, R. Morales, J. Ten, J. Llacer, R. Bernabeu, V. De Leo, R. Focarelli, A. Capaldo, A. Stendardi, L. Gambera, A. L. Marca, P. Piomboni, J. J. Kim, J. H. Kang, K. R. Hwang, S. J. Chae, S. H. Yoon, S. Y. Ku, S. Iliodromiti, T. W. Kelsey, R. A. Anderson, H. J. Lee, A. Weghofer, V. A. Kushnir, A. Shohat-Tal, E. Lazzaroni, D. H. Barad, N. N. Gleicher, T. Shavit, E. Shalom-Paz, O. Fainaru, M. Michaeli, E. Kartchovsky, A. Ellenbogen, J. Gerris, F. Vandekerckhove, A. Delvigne, N. Dhont, B. Madoc, J. Neyskens, M. Buyle, E. Vansteenkiste, E. De Schepper, L. Pil, N. Van Keirsbilck, W. Verpoest, D. Debacquer, L. Annemans, P. De Sutter, M. Von Wolff, N. a. Bersinger, F. F. Verit, S. Keskin, A. K. Sargin, S. Karahuseyinoglu, O. Yucel, S. Yalcinkaya, A. N. Comninos, C. N. Jayasena, G. M. K. Nijher, A. Abbara, A. De Silva, J. D. Veldhuis, R. Ratnasabapathy, C. Izzi-Engbeaya, A. Lim, D. A. Patel, M. A. Ghatei, S. R. Bloom, W. S. Dhillo, M. Colodron, J. J. Guillen, D. Garcia, O. Coll, R. Vassena, V. Vernaeve, H. Pazoki, G. Bolouri, F. Farokhi, M. A. Azarbayjani, M. S. Alebic, N. Stojanovic, R. Abali, A. Yuksel, C. Aktas, C. Celik, S. Guzel, G. Erfan, O. Sahin, H. Zhongying, L. Shangwei, M. Qianhong, F. Wei, L. Lei, X. Zhun, W. Yan, A. De Baerdemaeker, K. Tilleman, S. Vansteelandt, J. B. A. Oliveira, R. L. R. Baruffi, C. G. Petersen, A. L. Mauri, A. M. Nascimento, L. Vagnini, J. Ricci, M. Cavagna, F. C. Massaro, A. Pontes, J. G. Franco, W. El-khayat, M. Elsadek, F. Foroozanfard, H. Saberi, A. Moravvegi, M. Kazemi, Y. S. Gidoni, A. Raziel, S. Friedler, D. Strassburger, D. Hadari, E. Kasterstein, I. Ben-Ami, D. Komarovsky, B. Maslansky, O. Bern, R. Ron-El, M. P. Izquierdo, F. Araico, O. Somova, O. Feskov, I. Feskova, I. Bezpechnaya, I. Zhylkova, O. Tishchenko, S. K. Oguic, D. P. Baldani, L. Skrgatic, V. Simunic, H. Vrcic, D. Rogic, J. Juras, M. S. Goldstein, L. Garcia De Miguel, M. C. Campo, A. Gurria, J. Alonso, A. Serrano, E. Marban, L. Shalev, Y. Yung, G. Yerushalmi, C. Giovanni, J. Has, E. Maman, M. Monterde, A. Marzal, O. Vega, J. m. Rubio, C. Diaz-Garcia, A. Eapen, A. Datta, A. Kurinchi-selvan, H. Birch, G. M. Lockwood, M. C. Ornek, U. Ates, T. Usta, C. P. Goksedef, A. Bruszczynska, J. Glowacka, K. Jaguszewska, S. Oehninger, S. Nelson, P. Verweij, B. Stegmann, H. Ando, T. Takayanagi, H. Minamoto, N. Suzuki, N. Rubinshtein, S. Saltek, B. Demir, B. Dilbaz, C. Demirtas, W. Kutteh, B. Shapiro, H. Witjes, K. Gordon, M. P. Lauritsen, A. Pinborg, N. L. Freiesleben, A. L. Mikkelsen, M. R. Bjerge, P. Chakraborty, S. K. Goswami, B. N. Chakravarty, M. Mittal, R. Bajoria, N. Narvekar, R. Chatterjee, J. G. Bentzen, T. H. Johannsen, T. Scheike, L. Friis-Hansen, S. Sunkara, A. Coomarasamy, R. Faris, P. Braude, Y. Khalaf, A. Makedos, S. Masouridou, K. Chatzimeletiou, L. Zepiridis, A. Mitsoli, G. Lainas, I. Sfontouris, A. Tzamtzoglou, D. Kyrou, T. Lainas, A. Fermin, L. Crisol, A. Exposito, B. Prieto, R. Mendoza, R. Matorras, Y. Louwers, O. Lao, M. Kayser, A. Palumbo, V. Sanabria, J. P. Rouleau, M. Puopolo, M. J. Hernandez, J. M. Rubio, S. Ozturk, B. Sozen, A. Yaba-Ucar, D. Mutlu, N. Demir, H. Olsson, R. Sandstrom, L. Grundemar, E. Papaleo, L. Corti, E. Rabellotti, V. S. Vanni, M. Potenza, M. Molgora, P. Vigano, M. Candiani, M. Fernandez-Sanchez, E. Bosch, H. Visnova, P. Barri, B. J. C. M. Fauser, J. C. Arce, P. Peluso, C. M. Trevisan, F. A. Fonseca, P. Bakas, N. Vlahos, D. Hassiakos, D. Tzanakaki, O. Gregoriou, A. Liapis, G. Creatsas, E. Adda-Herzog, J. Steffann, S. Sebag-Peyrelevade, M. Poulain, A. Benachi, R. Fanchin, D. Zhang, F. Aybar, S. Temel, O. Hamdine, N. S. Macklon, J. S. Laven, B. J. Cohlen, A. Verhoeff, P. A. van Dop, R. E. Bernardus, G. J. E. Oosterhuis, C. A. G. Holleboom, G. C. van den Dool-Maasland, H. J. Verburg, P. F. M. van der Heijden, A. Blankhart, B. C. J. M. Fauser, F. J. Broekmans, J. Bhattacharya, A. Mitra, G. B. Dutta, A. Kundu, M. Bhattacharya, S. Kundu, P. Pigny, A. Dassonneville, S. Catteau-Jonard, C. Decanter, D. Dewailly, J. Pouly, F. Olivennes, N. Massin, M. Celle, N. Caizergues, M. Gaudoin, M. Messow, L. Vanhove, M. Peigne, P. Thomas, and G. Robin

Subjects
Gynecology, Gerontology, medicine.medical_specialty, Index (economics), Reproductive Medicine, business.industry, Rehabilitation, Obstetrics and Gynecology, Medicine, Stimulation, business
Abstract

Sao Paulo State Univ UNESP, Ctr Human Reprod Prof Franco Jr, Paulista Ctr Diag Res & Training, Dept Gynecol & Obstet,Botucatu Med Sch, Ribeirao Preto, Brazil

Published
2013
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5. Posters * Reproductive Endocrinology (i.e. PCOS, Menarche, Menopause etc.)

Author

R. Fujii, S. Fujita, T. Waseda, Y. Oka, H. Takagi, H. Tomizawa, T. Sasagawa, S. Makinoda, M. Cavagna, D. P. A. F. Braga, R. C. S. Figueira, T. Aoki, L. G. L. Maldonado, A. Iaconelli, E. Borges, s. Prabhakar, R. Dittrich, M. W. Beckmann, I. Hoffmann, A. Mueller, S. Kjotrod, S. M. Carlsen, P. E. Rasmussen, T. Holst-Larsen, J. Mellembakken, A. Thurin-Kjellberg, K. Haapaniemi Kouru, L. Morin Papunen, P. Humaidan, A. Sunde, V. von During, S. Pappalardo, C. Valeri, F. Crescenzi, C. Manna, H. N. Sallam, A. Polec, M. Raki, T. Tanbo, T. Abyholm, P. Fedorcsak, C. Tabanelli, A. P. Ferraretti, E. Feliciani, M. C. Magli, C. Fasolino, L. Gianaroli, T. Wang, C. Feng, Y. Song, M. Y. Dong, J. Z. Sheng, H. F. Huang, M. Sayyah Melli, M. Kazemi-shishvan, M. Snajderova, D. Zemkova, M. Pechova, L. Teslik, V. Lanska, I. Ketel, E. Serne, C. Stehouwer, T. Korsen, P. Hompes, Y. Smulders, L. Voorstemans, R. Homburg, C. Lambalk, J. Bellver, J. A. Martinez-Conejero, A. Pellicer, E. Labarta, P. Alama, M. A. B. Melo, J. A. Horcajadas, N. Agirregoitia, L. Peralta, R. Mendoza, A. Exposito, R. Matorras, E. Agirregoitia, M. Ajina, N. Chaouache, M. Gaddas, A. Souissi, Z. Tabka, A. Saad, M. Zaouali-Ajina, A. Zbidi, N. Eguchi, M. Jinno, A. Watanabe, J. Hirohama, N. Hatakeyama, Y. M. Choi, J. J. Kim, D. H. Kim, S. H. Yoon, S. Y. Ku, S. H. Kim, J. G. Kim, K. S. Lee, S. Y. Moon, Y. Xiong, X. Liang, Y. Li, X. Yang, L. Wei, T. Utsunomiya, S. Chu, P. Li, S. Akarsu, E. K. Dirican, K. O. Akin, C. Kormaz, U. Goktolga, S. T. Ceyhan, C. Kara, K. Nadamoto, S. Tarui, M. Ida, K. Sugihara, A. Haruki, A. Hukuda, Y. Morimoto, A. Albu, D. Albu, L. Sandu, G. Kong, L. Cheung, I. Lok, A. Pinto, L. Teixeira, H. Figueiredo, I. Pires, J. L. Silva Carvalho, M. L. Pereira, M. Faut, I. de Zuniga, D. Colaci, E. Barrios, A. Oubina, G. Terrado Gil, A. Motta, M. Horton, F. Sobral, M. Gomez Pena, N. Gleicher, D. H. Barad, Y. P. Li, H. C. Zhao, R. Z. Spaczynski, P. Guzik, B. Banaszewska, T. Krauze, A. Wykretowicz, H. Wysocki, L. Pawelczyk, E. Sarikaya, C. Gulerman, N. Cicek, L. Mollamahmutoglu, C. A. Venetis, E. M. Kolibianakis, K. Toulis, D. Goulis, K. Loutradi, K. Chatzimeletiou, I. Papadimas, I. Bontis, B. C. Tarlatzis, A. Schultze-Mosgau, G. Griesinger, B. Schoepper, T. Cordes, K. Diedrich, S. Al-Hasani, R. Gomez, V. Jovanovic, C. M. Sauer, C. J. Shawber, M. V. Sauer, J. Kitajewski, R. C. Zimmermann, L. Bungum, A. K. Jacobsson, F. Rosen, C. Becker, C. Y. Andersen, N. Guner, A. Giwercman, E. Kiapekou, E. Zapanti, D. Boukelatou, T. Mavreli, R. Bletsa, K. Stefanidis, P. Drakakis, G. Mastorakos, D. Loutradis, N. Malhotra, V. Sharma, S. Kumar, K. K. Roy, J. B. Sharma, A. Ferraretti, A. Crippa, I. Stanghellini, F. Robles, M. Serdynska-Szuster, S. L. Kristensen, E. Ernst, G. Toft, S. F. Olsen, J. P. Bonde, A. Vested, C. H. Ramlau-Hansen, F. F. Wang, F. Qu, G. L. Ding, V. Gallot, V. Genro, I. Roux, J. B. Scheffer, R. Frydman, R. Fanchin, S. Kanta Goswami, S. Banerjee, B. N. Chakravarty, S. N. Kabir, B. E. Seeber, E. Morandell, D. Kurzthaler, L. Wildt, H. Dieplinger, L. Tutuncu, S. Bodur, O. Dundar, R. Ron - El, R. Seger, D. Komarovsky, E. Kasterstein, A. Komsky, B. Maslansky, D. Strassburger, I. Ben-Ami, X. M. Zhao, R. M. Ni, L. Lin, M. Dong, C. H. Tu, Z. H. He, D. Z. Yang, C. Karamalegos, N. Polidoropoulos, C. Papanikopoulos, P. Stefanis, M. Argyrou, S. Doriza, V. Sisi, M. Moschopoulou, T. Karagianni, C. Mentorou, K. Economou, S. Davies, M. Mastrominas, A. Gougeon, M. J. De Los Santos, V. Garcia-Laez, F. Esteban, J. Crespo, H. W. R. Li, R. A. Anderson, W. S. B. Yeung, P. C. Ho, E. H. Y. Ng, H. I. Yang, K. E. Lee, S. K. Seo, H. Y. Kim, S. H. Cho, Y. S. Choi, B. S. Lee, K. H. Park, D. J. Cho, R. Hart, D. Doherty, T. Mori, M. Hickey, D. Sloboda, R. Norman, R. C. Huang, L. Beilin, N. Freiesleben, K. Lossl, T. H. Johannsen, A. Loft, S. Bangsboll, D. Hougaard, L. Friis-Hansen, M. Christiansen, A. Nyboe Andersen, M. Y. Thum, H. Abdalla, J. Martinez-Salazar, G. De la Fuente, G. Kohls, J. A. Garcia Velasco, E. Yasmin, S. Kukreja, J. Barth, A. H. Balen, T. Esra, T. Var, A. Citil, M. Dogan, C. I. Messini, K. Dafopoulos, N. Chalvatzas, P. Georgoulias, G. Anifandis, I. E. Messinis, O. Celik, S. Hascalik, N. Celik, I. Sahin, S. Aydin, C. W. Hanna, K. L. Bretherick, C. C. Liu, M. D. Stephenson, W. P. Robinson, Y. V. Louwers, M. O. Goodarzi, K. D. Taylor, M. R. Jones, J. Cui, S. Kwon, Y. D. I. Chen, X. Guo, L. Stolk, A. G. Uitterlinden, J. S. E. Laven, R. Azziz, R. Navaratnarajah, B. Grun, J. Sinclair, D. Dafou, S. Gayther, J. F. Timms, P. J. Hardiman, Y. Ye, R. Wu, J. Ou, S. D. Kim, B. C. Jee, J. Y. Lee, C. S. Suh, J. H. Jung, B. C. Opmeer, K. A. Broeze, S. F. Coppus, J. A. Collins, J. E. Den Hartog, J. A. Land, P. J. Van der Linden, P. Marianowski, E. Ng, J. W. Van der Steeg, P. Steures, A. Strandell, B. W. Mol, T. B. Tarlatzi, D. Kyrou, A. Mertzanidou, H. M. Fatemi, P. Devroey, T. E. Batenburg, T. E. Konig, A. Overbeek, R. Schats, C. B. Lambalk, D. Carone, G. Vizziello, A. Vitti, R. Chiappetta, H. O. Topcu, B. Yuksel, M. Islimye, J. Karakaya, M. ozat, S. Batioglu, W. K. Kuchenbecker, H. Groen, J. H. Bolster, S. van Asselt, B. H. Wolffenbuettel, A. Hoek, Y. Wu, H. Pan, X. Chen, H. Huang, A. Zavos, C. Verikouki, L. Van Os, C. Q. J. Vink-Ranti, P. M. Rijnders, K. E. Tucker, C. A. M. Jansen, F. Lucco, C. Pozzobon, E. Lara, D. Galliano, A. Ballesteros, B. Ghoshdastidar, S. P. Maity, S. Ghoshdastidar, M. Luna, G. Vela, B. Sandler, J. Barritt, E. D. Flisser, A. B. Copperman, D. Nogueira, L. Prat, J. Degoy, F. Bonald, J. Montagut, S. Maity, S. Chen, C. Luo, H. Zhen, X. Shi, F. Wu, Y. Ni, G. Merdassi, A. Chaker, K. Kacem, M. Benmeftah, S. Fourati, D. Wahabi, F. Zhioua, A. Zhioua, P. Saini, A. Saini, R. Sugiyama, K. Nakagawa, Y. Nishi, H. Jyuen, Y. Kuribayashi, M. Inoue, N. Jancar, E. Vrtacnik Bokal, I. Virant-Klun, J. H. Lee, S. G. Kim, E. M. Cha, I. H. Park, K. H. Lee, E. M. Dahdouh, P. Desrosiers, P. St-Michel, M. Villeneuve, J. Y. Fontaine, L. Granger, O. Ramon, J. Burgos, E. Abanto, M. Gonzalez, J. Mugica, B. Corcostegui, J. Tal, G. Ziskind, G. Ohel, Y. Paltieli, G. Paz, N. Lewit, H. Sendel, S. Khouri, I. Calderon, P. van Gelder, H. G. Al-Inany, R. Antaki, N. Dean, L. Lapensee, M. Racicot, S. Menard, I. Kadoch, L. J. Meylaerts, L. Dreesen, M. Vandersteen, C. Neumann, U. Zollner, K. Kato, T. Segawa, S. Kawachiya, T. Okuno, T. Kobayashi, Y. Takehara, O. Kato, K. Jayaprakasan, L. Nardo, J. Hopkisson, B. Campbell, and N. Raine-Fenning

Subjects
Menopause, Gynecology, medicine.medical_specialty, Human reproduction, Reproductive Medicine, business.industry, Rehabilitation, medicine, Menarche, Obstetrics and Gynecology, medicine.disease, business
Abstract

This journal suppl. entitled: Abstracts of the 26th Annual Meeting of the European Society of Human Reproduction and Embryology, Rome, Italy, 27-30 June 2010

Published
2010
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6. Novasure impedance control system versus microwave endometrial ablation for the treatment of dysfunctional uterine bleeding: a double-blind, randomized controlled trial

Author

D, Athanatos, G, Pados, C A, Venetis, P, Stamatopoulos, D, Rousso, D, Tsolakidis, C P, Stamatopoulos, and B C, Tarlatzis

Subjects
Adult, Metrorrhagia, Treatment Outcome, Double-Blind Method, Catheter Ablation, Electric Impedance, Humans, Female, Middle Aged, Microwaves, Amenorrhea, Menorrhagia, Endometrial Ablation Techniques
Abstract

To compare the efficacy and safety of two different second-generation ablation devices, Novasure impedance control system and microwave endometrial ablation (MEA), in cases of abnormal uterine bleeding (AUB).This is a randomized controlled trial that took place in a single Gynecological Department of a University Hospital. Sixty-six women with dysfunctional uterine bleeding (DUB), unresponsive to medical treatment, were included in the trial. The ratio of women allocated to bipolar radio-frequency ablation or MEA was 1:1. Follow-up assessments were carried out at three and 12 months post-ablation. The present main outcome measure was amenorrhea rates 12-months post-treatment.The rate of amenorrhea at 12-months post-ablation was significantly higher in women treated by Novasure (25/33; 75.8%) as compared to those treated by MEA (8/33; 24.2%) (rate difference: +51.5%, 95% CI: +27.8 to +67.7).In women with DUB, endometrial ablation with Novasure bipolar radiofrequency impedance-controlled system is associated with increased rates of amenorrhea at 12-months post-treatment as compared to the MEA method.

Published
2015

7. Iron overload and left ventricular performance in beta thalassemia

Author

D T, Kremastinos, P K, Toutouzas, G P, Vyssoulis, C A, Venetis, and D G, Avgoustakis

Subjects
Adult, Heart Failure, Adolescent, Echocardiography, Child, Preschool, Heart Ventricles, Ferritins, Humans, Thalassemia, Blood Transfusion, Cardiac Output, Child
Abstract

The effect of iron overload on left ventricular (LV) performance was studied in 60 patients with beta-thalassemia. Patients were divided into 3 groups according to the number of blood units (BU) received. Clinically, 14 patients were in advanced classes (III and IV) of congestive heart failure (CHF). LV performance was extensively studied by M-mode echocardiography, and the results were correlated to BU transfused and CHF presence. E point-septal separation, LV systolic and diastolic dimensions had greater values in CHF patients (p less than 0.0001). The percentage shortening of the internal LV diameter and the peak velocity of circumferential fiber shortening were reduced in CHF patients (p less than 0.01 and 0.0001), while the percentage thickening of the LV posterior wall (PW) and interventricular septum (IVS), were independent of CHF presence. LVPW relaxation and indices of the overall diastolic LV function had similar values in all groups. The relation of all systolic and diastolic indices to BU was low (r less than 0,6) and in most cases indifferent (p:NS). A special finding was observed in 4 CHF patients, where segmental IVS dyskinesia contrasted with a satisfactory LVPW motion. The above results indicate that CHF in beta-thalassemia is not the consequence of volume and iron overload, but that these factors are predisposing towards the development of a specific type of cardiomyopathy.

Published
1984

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