1. The effect of indomethacin and reserpine on renal vascular escape
- Author
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M C, Fonteles and C A, de Lima e Forti
- Subjects
Male ,Perfusion ,Norepinephrine ,Reserpine ,Dose-Response Relationship, Drug ,Indomethacin ,Animals ,Female ,Vascular Resistance ,Rabbits ,In Vitro Techniques ,Kidney - Abstract
Isolated rabbit kidneys were perfused with Krebs-Henseleit solution in an open system designed to allow study of dose-response relationships. The effects of the cyclooxygenase inhibitor indomethacin and of reserpine on (norepinephrine) noradrenaline (NOR)-induced renal vascular escape were studied. Indomethacin (50 mg/Kg) was given two hours prior to surgery followed by continuous infusion (0.33 mg/min), and blocked renal vascular escape in all doses of NOR tested (10(-7)-10(-4) M) by 70-80%. Reserpine (10 mg/Kg, given 10-12 hours prior to organ perfusion), also suppressed renal vascular escape significantly by 80-90%. We conclude that there is a participation of prostaglandins in noradrenaline induced escape in the perfused rabbit kidney.
- Published
- 1993