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1. Pain Management Strategies After Orthopaedic Trauma: A Mixed-Methods Study with a View to Optimizing Practices

Author

Grzelak S, Bérubé M, Gagnon MA, Côté C, Turcotte V, Pelet S, and Belzile É

Subjects
orthopeadic trauma, pain, pharmacological strategies, non-pharmacological strategies, opioids, cannabis., Medicine (General), R5-920
Abstract

Sonia Grzelak,1,2 Mélanie Bérubé,1,2 Marc-Aurèle Gagnon,1 Caroline Côté,1,2 Valérie Turcotte,3 Stéphane Pelet,4 Étienne Belzile4 1Population Health and Optimal Practices Research Unit (Trauma - Emergency - Critical Care Medicine), Laval University Research Center (Hôpital de l’Enfant-Jésus), Quebec City, QC, Canada; 2Faculty of Nursing, Laval University, Quebec City, QC, Canada; 3Nursing Department, CIUSSS du Nord-de-l’Île-de-Montréal, Hôpital du Sacré-Coeur de Montréal, Montréal, QC, Canada; 4Department of Orthopedic Surgery, CHU de Québec-Université Laval (Hôpital de l’Enfant-Jésus), Quebec City, QC, CanadaCorrespondence: Sonia GrzelakPopulation Health and Optimal Practices Research Unit, Laval University Research Center (Hôpital de l’Enfant-Jésus), 1401, 18 e rue, Quebec City, QC, G1V 1Z4, Canada, Tel +1 418 649-0252, ext 66600, Fax +1 418-649-5733, Email sonia.grzelak.1@ulaval.caPurpose: To examine 1) pain management strategies within the care trajectory of orthopaedic trauma patients and patients’ perception of their effectiveness, 2) adverse effects (AEs) associated with pharmacological treatments, particularly opioids and cannabis, and 3) patients’ perceptions of strategies that should be applied after an orthopaedic trauma and support that they should obtain from health professionals for their use.Patients and Methods: This study was conducted with orthopaedic trauma patients in a level 1 trauma center. A convergent mixed-methods design was used. Data on pain experience, pain management strategies used and AEs were collected with self-administered questionnaires at hospital discharge (T1) and at 3 months after injury (T2). Patients’ preferences about the pain management strategies used, the required support and AEs were further examined through semi-structured individual interviews at the same time measures. Descriptive statistics and thematic analyses were performed.Results: Seventy-one patients were recruited and 30 individual interviews were undertaken. Pharmacological pain management strategies used at T1 and T2 were mainly opioids (95.8%; 20.8%) and acetaminophen (91.5%; 37.5%). The most frequently applied non-pharmacological strategies were sleep (95.6%) and physical positioning (89.7%) at T1 and massage (46.3%) and relaxation (32.5%) at T2. Findings from quantitative and qualitative analyses highlighted that non-pharmacological strategies, such as comfort, massage, distraction, and physical therapy, were perceived as the most effective by participants. Most common AEs related to opioids were dry mouth (78.8%) and fatigue (66.1%) at T1 and insomnia (30.0%) and fatigue (20.0%) at T2. Dry mouth (28.6%) and drowsiness (14.3%) were the most reported AEs by patients using recreational cannabis. An important need for information at hospital discharge and for a personalized follow-up was identified by participants during interviews.Conclusion: Despite its AEs, we found that opioids are still the leading pain management strategy after an orthopaedic trauma and that more efforts are needed to implement non-pharmacological strategies. Cannabis was taken for recreational purposes but patients also used it for pain relief. Support from health professionals is needed to promote the adequate use of these strategies.Keywords: orthopaedic trauma, pain, pharmacological strategies, non-pharmacological strategies, opioids, cannabis

Published
2022

3. Petrography, chemical composition, and age constraints of mafic intrusions from the Mesoproterozoic Soisson Intrusive Suite in the southeastern Churchill Province (Canada)

Author

Sappin, A.-A., Houlé, M.G., Corrigan, D., Bédard, M.-P., Rayner, N., Wodicka, N., and Brind'Amour-Côté, C.

Subjects
Olivine -- Composition -- Testing, Intrusions (Geology) -- Natural history, Magmatism -- Environmental aspects, Earth sciences
Abstract

Several kilometre-scale gabbroic intrusions with well-preserved cumulate textures occur over a ~180 km northwest-southeast strike length area in the Core Zone, within the southeastern Churchill Province. These intrusions (1312-1311 Ma) are devoid of structural and metamorphic overprint and are mainly composed of olivine gabbro. Their overlapping petrographic, geochemical, and mineralogical characteristics suggest that all of these gabbroic intrusions are co-genetic and form the Soisson Intrusive Suite. The Soisson intrusions formed from basaltic parental magmas with low MgO (~6-7 wt.%) and high Fe-Ti contents. Overall, they are similarly fractionated at the regional scale and incorporated various amounts of upper crustal material, as indicated by field (e.g., xenoliths, hybrid zones) and geochemical (e.g., high HILE/MILE, depletion in Nb[+ or -]Ta) evidences. The Soisson Intrusive Suite has petrological, geochemical, and mineral chemistry similarities with the troctolite and olivine gabbro cumulates of the Voisey's Bay and Mushuau intrusions from the ca. 1363 to 1289 Ma Nain Plutonic Suite (NPS), and appears to be contemporaneous with its younger gabbroic-troctolitic intrusion phase, suggesting that the Soisson Intrusive Suite and the gabbroic-troctolitic intrusions of the NPS were formed by similar petrological processes. Furthermore, like many gabbroic-troctolitic intrusions of the NPS (e.g., Voisey's Bay intrusion), the Soisson intrusions contain Ni-Cu-Co magmatic sulfide mineralization. Among the Soisson intrusions, the Papavoine intrusion located in the southern part of this intrusive suite may be the most prospective intrusion as a Ni, Cu, and Co exploration target. Overall, the Soisson Intrusive Suite's similarity with the NPS raises questions about their potential genetic link and magmatic connectivity at depth. Key words: olivine gabbro, cumulate, Ni-Cu-Co mineralization, Core Zone, southeastern Churchill Province, Mesoproterozoic. Plusieurs intrusions gabbroïques kilométriques présentant des textures de cumulat bien préservées sont présentes sur un secteur d'environ 180 km dans l'axe NO-SE dans la Zone noyau de la partie sud-est de la province de Churchill. Aucun élément structural ou métamorphique n'est surimposé sur ces intrusions (1312-1311 Ma) principalement constituées de gabbro à olivine. Leurs caractéristiques pétrologiques, géochimiques et minéralogiques communes portent à croire que toutes ces intrusions gabbroïques sont cogénétiques et constituent la Suite intrusive de Soisson. Les intrusions de Soisson se sont formées à partir de magmas parentaux basaltiques pauvres en MgO (~6-7% en poids) et riches en Fe-Ti. En général, elles sont caractérisées par un degré semblable de cristallisation fractionnée à l'échelle régionale et ont incorporé des quantités variables de matériau de la croûte supérieure, comme l'indiquent les observations de terrain (p. ex., xénolithes, zones hybrides) et géochimiques (p. ex., rapport en éléments lithophiles fortement incompatibles sur les éléments lithophiles modérément incompatibles élevé, appauvrissement en Nb[+ or -]Ta). La Suite intrusive de Soisson présente des similitudes pétrologiques, géochimiques et sur le plan de la chimie des minéraux avec les cumulats troctolitiques et de gabbro à olivine des intrusions Voisey's Bay et Mushuau de la Suite plutonique de Nain (SPN) mise en place il y a environ 1363 Ma à 1289 Ma, et semble contemporaine à la phase intrusive à gabbro-troctolite plus récente de cette suite, ce qui donne à penser que la Suite intrusive de Soisson et les intrusions gabbroïques-troctolitiques de la SPN se sont formées par des processus pétrologiques semblables. En outre, à l'instar de nombreuses intrusions gabbroïques-troctolitiques de la SPN (p. ex., l'intrusion Voisey's Bay), les intrusions de Soisson renferment une minéralisation de sulfures magmatiques de Ni-Cu-Co. Parmi les intrusions de Soisson, l'intrusion Papavoine, dans la partie sud de la suite intrusive, pourrait constituer la cible d'exploration la plus intéressante pour les minéralisations en Ni, Cu et Co. Globalement, la similitude de la Suite intrusive de Soisson et de la SPN soulève des questions touchant à leur possible lien génétique et leur connectivité magmatique en profondeur. Mots-clés : gabbro à olivine, cumulat, minéralisation en Ni-Cu-Co, Zone noyau, sud-est de la province de Churchill, Mésoprotérozoïque., Introduction The discovery in the 1990s of the world-class Ni-Cu-Co Voisey's Bay deposit hosted by a gabbroic-troctolitic intrusion, belonging to the Mesoproterozoic Nain Plutonic Suite (NPS), has stimulated exploration for [...]

Published
2022
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12. Investigating the Impact of Stress on Pain: A Scoping Review on Sense of Control, Social-Evaluative Threat, Unpredictability, and Novelty (STUN Model)

Author

Ghoussoub K, Côté CI, Fortier M, Nauche B, Rainville P, and Pagé MG

Subjects
stress, pain, stun, control, unpredictability, threat, novelty, Medicine (General), R5-920
Abstract

Karen Ghoussoub,1,2 Catherine Isadora Côté,2 Maude Fortier,2 Bénédicte Nauche,3 Pierre Rainville,4,5 M Gabrielle Pagé1,2,6 1Department of Psychology, Faculty of Arts and Science, Université de Montréal, Montreal, Quebec, Canada; 2Research Center of the Centre hospitalier de l’Université de Montréal (CRCHUM), Montreal, Quebec, Canada; 3CHUM Library, Centre hospitalier de l’Université de Montreal (CHUM), Montreal, Quebec, Canada; 4Centre de recherche de l’Institut universitaire de gériatrie de Montréal, CIUSSS Centre-sud-de l’île de Montréal, Montreal, Quebec, Canada; 5Department of Stomatology, Université de Montréal, Montreal, Quebec, Canada; 6Department of Anesthesiology and Pain Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, CanadaCorrespondence: M Gabrielle Pagé, Centre de recherche du Centre hospitalier de l’Université de Montréal (CRCHUM), Tour Saint-Antoine, office S03-910, 850 St-Denis, Montreal, QC, H2X 0A9, Canada, Email gabrielle.page@umontreal.caBackground: Stress can have paradoxical effects on pain, namely hyperalgesia and hypoalgesia. Four situational characteristics activate the hypothalamic–pituitary–adrenal axis, leading to a physiological stress response: lacking Sense of control, social-evaluative Threat, Unpredictability and Novelty (STUN). This scoping review reports on the types of evidence published on the effects of STUN characteristics on pain outcomes.Databases/Data Treatment: Searches of primary electronic databases were performed to identify articles published on adults between 1990 and 2021 that contained search terms on pain and stress/STUN characteristics. A total of 329 articles were included in the analysis.Results: Only 3.3% of studies examined simultaneously > 1 STUN component. Almost all observational studies (177/180) examined the association between perceived stress and pain without measuring physiological stress responses. Of the 130 experimental studies, 78 (60.0%) manipulated stressful characteristics through nociception, and only 38.5% assessed if/how stress manipulation impacted perceived stress.Conclusion: There is a clear lack of integration of the characteristics that trigger a physiological stress response in the pain field. Only 3.3% of studies examined simultaneously more than one STUN component and there is an unequal attention given to individual components of the STUN framework. Recommendations for future research include selection of stress manipulations/measurements that are more precisely inducing/reflecting neurobiological mechanisms of stress responses to insure valid integration of scientific knowledge.Keywords: stress, pain, STUN, control, unpredictability, threat, novelty

Published
2024

13. Spartacus attending the 2005 AAAI conference

Author

Michaud, F., Côté, C., Létourneau, D., Brosseau, Y., Valin, J.-M., Beaudry, É., Raïevsky, C., Ponchon, A., Moisan, P., Lepage, P., Morin, Y., Gagnon, F., Giguère, P., Roux, M.-A., Caron, S., Frenette, P., and Kabanza, F.

Published
2007
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14. Non-state actors in international dispute settlement: The case of domestic investment statutes

Author

Kanehara, A, Côté, C-E, Claussen, K, Scott, KN, Hepburn, J, Kanehara, A, Côté, C-E, Claussen, K, Scott, KN, and Hepburn, J

Abstract

Non-state actors are now prominent parties in several fields of international dispute settlement, most notably as foreign investor claimants in disputes under investment treaties. But, alongside treaties, many states have also developed domestic investment statutes. These laws offer protections similar to investment treaties, and are increasingly also relied on by foreign investors to bring claims against states. Unlike investment treaties, however, investment statutes have attracted limited scholarly scrutiny. The burgeoning instances of non-state actor claims under investment statutes have pushed tribunals to clarify the nature of these instruments. The many similarities between investment statutes and investment treaties may have led some to conclude that the former raise no distinct issues; indeed, in two of the cases under investment statutes to date, the tribunal referred to the claims as ‘treaty claims’. But investment statutes are clearly not treaties, and they provoke many questions for observers seeking to understand their place in international law. This Chapter argues that domestic investment statutes can plausibly be characterized as unilateral acts in international law, as well as being characterized as domestic law. The Chapter examines the significant consequences that follow from the differing characterizations of these hybrid statutes, including how or whether the international law of state responsibility will apply where a non-state actor invokes a domestic statute.

Published
2020

15. 10th Annual scientific session September 29–October 2, 2005 Seattle, Washington

Author

Hacker, M, Jakobs, T, Matthiesen, F, Vollmar, C, Nikolaou, K, Becker, C, Knez, A, Pfluger, T, Tiling, R, Hahn, K, Iwanochko, RM, Petrovici, R, Lee, DS, Husain, M, Woo, A, Siu, S, Masry, HZ El, Jaradat, Z, Khan, BR, Kalaria, VG, Mahenthiran, J, Raiesdana, A, Sawada, SG, Shah, DP, Virnich, DE, Ward, RP, Gundeck, EL, Williams, KA, Spencer, KT, Lang, RM, Akutsu, Y, Gewirtz, H, Gregory, SA, Zervos, GD, Thomas, GS, Yasuda, T, Duvall, WL, Croft, LB, Pungoti, C, Henzlova, MJ, Hage, FG, Heo, J, Iskandrian, AE, Johnson, NP, Leonard, SM, Kansal, P, Wu, E, Holly, TA, Michelena, HI, Stepnowski, D, Frain, V, Dempsey, DT, Kowalski, C, Van Decker, WA, Smanio, P, Rodrigues, F, Meneghelo, R, Mastrocolla, L, Thorn, A, Piegas, L, Beraldo, P, Mello, R, Tebexreni, S, ten Cate, TJF, Visser, FC, Panhuyzen-Goedkoop, NM, Verzijlbergen, JF, van Hemel, NM, Thompsen, J, Athar, H, Sainani, V, O’Sullivan, D, Leka, I, Heller, GV, Jansen, M, Grasman, M, Stier, A, Konnann, O, Silva, JA, Vitola, JV, Cunha, C, Cerci, MS, Ribeiro, OF, Jansen, MHA, Grasman, ME, Zukovski, T, Mickevicz, C, Visser, F, Snyder, K, Polepalle, D, Nichols, KJ, Dim, U, Akinboboye, OO, Vijay Anand, D, Lim, E, Nagar, K, Raval, U, Lahiri, A, Elhendy, A, Huurman, A, Schinkel, AF, Bax, JJ, van Domburg, RT, Valkema, R, Poldermans, D, Heiba, SI, Katzel, JA, Altinyay, E, Milarodovic, R, Castellon, I, Raphael, B, Abdel-Dayem, HA, Coppola, J, Heston, TF, Høilund-Carlsen, PF, Johansen, A, Vach, W, Christensen, HW, Møldrup, M, Haghfelt, T, Kumar, A, Stricker, S, Das, MK, Oddis, CV, Byrne, D, Myers, JS, Churchwell, AL, Churchwell, KB, Nichols, KJ, Dim, U, Wang, Y, Akinboboye, OO, Bergmann, SR, Druz, RS, Gopal, AS, Borges, A, Ngai, K, Chen, J, Caputlu-Wilson, SF, Shi, H, Galt, JR, Faber, TL, Garcia, EV, Cole, V, Habtemarkos, R, Sun, L, Lacy, J, Kjaer, A, Cortsen, A, Federspiel, M, Holm, S, O’Connor, M, Hesse, B, Lewin, HC, Hyun, MC, Carboni, GP, Tavolozza, M, Fukuzawa, S, Ozawa, S, Inagaki, M, Sugioka, J, Okino, S, Ichikawa, S, Mohart, JM, Fairlamb, JE, Hutter, AJ, Gutierrez, FR, Zheng, J, Lesniak, DM, Gropler, RJ, Woodard, PK, Santana, C, Esteves, FP, Lerakis, S, Halkar, R, Narla, R, Santana, CA, Alvarez, A, Halkar, RK, Chen, S, Yao, Z, Ramrakhiani, S, Safadi, AH, Foltz, JM, Stricker, SL, Williams, AA, Grewal, KS, George, PB, Richards, DR, Calnon, DA, Bhama, A, Goetze, S, Wahl, RL, Elmquist, T, Mazzara, J, Hsu, BL, Moser, KW, Bateman, TM, Stoner, C, Case, JA, Matsumoto, N, Sato, Y, Yoda, S, Muromoto, M, Nalamolu, VRP, Patel, RN, Dias, JK, Kaminski, RJ, Kersey, TW, Robinson, VJB, Oaknin, JH, Shwartz, SC, Pagnanelli, RA, Coleman, RE, Borges-Neto, S, Cullom, SJ, Noble, GL, Masse, M, McGhie, AI, Friedman, JD, Devabhaktuni, M, Hickey, KT, Sciacca, RR, Giedd, KN, Johnson, U, Bokhari, S, Nemirovsky, D, Machac, J, Almeida, D, Kanayama, S, Satake, O, Kajinami, K, Hertenstein, GK, Volker, LL, Verdes, L, Folks, RD, Clements, IP, Mullan, BP, Breen, JF, McGregor, CG, Côté, C, Dumont, M, Lefebvre, J, Poirier, L, Lacourcière, Y, Gupta, R, Aqel, RA, Mehta, D, Clay, MA, Zoghbi, G, Hwang, K-H, Kim, J-H, Choe, W, Kim, N-B, Khateeb, R, Keefer, PM, Vedala, G, Mahajan, NM, Shetty, VS, Thekkott, DT, Hollander, GH, Greengart, AG, Shani, JS, Lichstein, EL, Raza, M, Panjrath, G, Meesala, M, Ghanbarinia, A, Jain, D, Seo, I, Del Priore, E, Almonte, A, Kappes, R, Fedida, A, Ong, K, Kritzman, JN, Dey, S, Corbett, JR, Ficaro, EP, Stowers, SA, Tomlinson, GC, Cunningham, MS, Guilarte, NM, Carrio, I, Lundbye, JB, Katten, D, Ahlberg, A, Boden, WE, Cyr, G, Paiesdana, A, and Murthy, DR

Published
2005
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16. Poster display II clinical general

Author

Gurgenyan, S. V. Svetlana, Vatinyan, S. K. H., Nikogosyan, K. G., Edilyan, L. B., Chobanyan, B. G., Lacourcière, Y., Marcel Dumont, M., Lefebvre, J., Poirier, L., Côté, C., Peix, A. Amalia, Alonso, O., Chae, I. H., Chung, J. K., Gutierrez, C., Kropp, J., Onsel, C., Silvasi, I., Llerena, L., Padhy, A. K., Garcia-Barreto, D., Trapaga, A., Asen, L., Infante, O., Ponce, F., Cabrera, L. O., Valiente, J., Tornes, F., Guerrero, I., Zayas, R., ones, M. A. Quin, Castro, J., Fayad, Y., Carrillo, R., Paz, A. De, Mehlsen, J. Jesper, Hædersdal, C., Daou, D. Doumit, Benada, A., Lebtahi, R., Idy-Peretti, I., Guludec, D. Le, Coaguila, C., Vilain, D., Leenhardt, A., Heinicke, N. Norbert, Benesch, B., Kaiser, T., Seegmüller, M., Schönberger, J., Eilles, C., Riegger, G. A. J., Holmer, S., Luchner, A., Kouris, N. T. Nikos, Kontogianni, D. D., Goranitou, G. S., Sifaki, M. D., Kalkandi, E. M., Grassos, H. E., Papoulia, E., Babalis, D. K., Moralidis, E. Efstratios, Spyridonidis, T., Arsos, G., Karakatsanis, K., Karatzas, N., Parameswaran, R. V. Ramanathapuram, Sundaram, P. S. Palaniswamy Shanmuga, Padma, S., Haridas, K. K., Zachariah, M., Kumar, S., Feola, M. Mauro, Leonardi, G., Peano, S., Bianchi, A., Dutto, P., Guala, E., Biggi, A., Uslenghi, E., Filardi, P. Pasquale Perrone, Pace, L., Dellegrottaglie, S., Corrado, L., Cafiero, M., Camerino, R., Maglione, A., Polimeno, M., Zarrilli, A., Chiariello, M., Giorgetti, A. Assuero, Gimelli, A., Marini, C., Schluter, M., Kusch, A., D’Aragona, I., Marzullo, P., Gimelli, A. Alessia, Stanislao, M., Zanco, P., Inglese, E., Bertelli, P., Valle, G., Tassone, F., Pepino, R., Francini, A., Garrone, O., Occelli, M., Merlano, M., Florimonte, L. Luigia, Pagani, L., Piatti, L., Butti, I., Maffioli, L. S., Casorelli, E., Dottore, F. Del, Gentili, G., Agostini, M., Pieri, P. L. Pierluigi, Milan, E., Giubbini, R. Raffaele, Mazzanti, M. Marco, Serenelli, M., Perna, G. P., Ferro, A., Duilio, C., Santomauro, M., Salvatore, M., Cuocolo, A. Alberto, Bertagna, F., Bosio, G., Terzi, A., Paghera, B., Kaneta, T. Tomohiro, Otani, H., Hakamatsuka, T., Fukuda, H., Nakazato, R. Ryo, Moroi, M., Kunimasa, T., Furuhashi, T., Sugi, K., Yasuhi, W. Watanabe, Akihiro, S., Yukawa, A., Ryu, K., Kimio, T., Yasuhiko, T., Nariaki, E., Yasunori, W., Akashi, Y. J. Yoshihiro, Musha, H., Kida, K., Itoh, K., Inoue, K., Kawasaki, K., Hashimoto, N., Nakazawa, K., Miyake, F., Fukuzawa, S. Shigeru, Ozawa, S., Inagaki, M., Sugioka, J., Okino, S., Matsuo, S. Shinro, Matsumoto, T., Nakae, I., Masuda, D., Horie, M., Mori, Y. Yoshitomo, Takahashi, K., Masai, M., Kawasaki, D., Kanemori, T., Okuda, S., Tanabe, K., Ohyanagi, M., Takahashi, K. Keiko, Masai, M., Mori, Y., Tanabe, K., OKuda, S., Toyama, T. Takuji, Hoshizaki, H., Seki, R., Isobe, N., Kawaguchi, R., Oshima, S., Taniguchi, K., Nakagawa, K. Keiichi, Sekine, T., Yamazaki, M., Komuro, I., Kim, K. M. Kyeong Min, Teramoto, N., Jino, H., Ohta, Y., Watabe, H., Hayashi, T., Iida, H., Nishimura, T. Tohru, Nagae, A., Morishima, K., Shigeyama, T., Shimoyama, K., Yoshino, H., Kawai, Y. Yuko, Jeong, S. Y., Lee, J. Jae-Tae, Seo, J. H., Bae, J. H., Ahn, B. C., Chae, S. C., Lee, K. B., Cho, I. Ihnho, Chun, K., Won, K., Lee, H., Hong, G., Park, J., Shin, D., Kim, Y., Shim, B., Pavlovic, J. Maksimovic, Peovska, I. Irena, Vavlukis, M., Gorceva, D. Pop, Majstorov, V., Alexanderson, E. Erick, Meave, A., Ricalde, A., Teresinska, A. Anna, Sliwinski, M., Konieczna, S., Szymanska, M., Hendzel, P., Juraszynski, Z., Debski, A., Szumilak, B., Kostkiewicz, M. Magdalena, Wilkolek, P., Pasowicz, M., Klimeczek, P., Pieniazek, P., Przewlocki, T., Pieculewicz, M., Tracz, W., Szot, W., Trebacz, J., Zmudka, K., Podolec, P., Dziuk, M. Miroslaw, Kazmierczak, A., Kot, E., Pietrzykowski, J., Cholewa, M., Coutinho, M. C. Maria Azevedo, Correia, M. J., Cantinho, G., Conceição, I., Bernardes, A., Silva, A., Gaspar, F., Cunha, J. A. Correia da, Lourenço, C. Cândida, Roque, C., Ferrer-Antunes, A., Ferreira, M., Providência, L. A., Lima, J., Abreu, A. Ana, Castillejos, L., Henriksson, I., Oliveira, L., Rosário, L., Geão, A., Pereira, E., Colarinha, P., Romero-Farina, G., Candell-Riera, J., Aguadé-Bruix, S. Santiago, Leon, G. De, Caresia, A. P., Mila-Lopez, M., Garcia-Alonso, C., Pifarre-Montaner, P., Negre-Buso, M., Castell-Conesa, J., Mestre-Fusco, A., Porta-Biosca, F., Aguadé-Bruix, S. Santiago, Muxi, A. Africa, Paredes, P., Ortin, J., Duch, J., Diaz-Infante, E., Fuertes, S., Orus, J., Mont, L. L., Pons, F., Pollack, C., Hellermann, J. P., Namdar, M., Siegrist, P. T. Patrick, Koepfli, P., Bartenstein, N., Schurr, U., Jenni, R., Kaufmann, P. A., Hassad, R. Rim, Hamami, H., Sellem, A., Brahim, H. Ben, Caglar, M. Meltem, Mahmoudian, B., Aytemir, K., Kahraman, S., Arýcý, M., Kabakcý, G., Karabulut, E., Akincioglu, C. Cigdem, Berman, D. S., Nishina, H., Hayes, S. W., Kavanagh, P. B., Friedman, J. D., Slomka, P. J., Germano, G., Entok, E. Emre, Cavusoglu, Y., Vardareli, E., Timuralp, B., Cheetham, A., Naylor, V., Ghiotto, F., McGhie, J., Al-Housni, M. B., Kelion, A. D. Andrew, Hutchings, F., Hinton-Taylor, S., Birkbeck, P., Thatikonda, S., Feldkamp, M., Rosamond, T. Thomas, Raza, M., Panjrath, G. S. Gurusher, Haider, A., Jain, D., Yang, A., Schumacher, R., Reynolds, J., Clark, E., Speiser, D., Schindel, M., Hackney, T., Vacek, J., Jindal, V. Vikas, Dim, U. Uzodinma, Hamburg, L. M., Mouradian, V., Nichols, K. J., Akinboboye, O. O., Snyder, K., Polepalle, D., DePuey, G. Gordon, Khattak, H., Friedman, M., Thompson, L., Thompson, R. C. Randall, McGhie, A. I., Moser, K., O’Keefe, J. H., Fritsch, N., Bateman, T. M., Mut, F., Vidal, I., Rener, A., Nuñez, M., Alvarez, B., and Beretta, M. Mario

Published
2005
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17. Controlled Synthesis of Carbon Nanotubes by Various CVD and PECVD Methods

Author

Ionescu, M. I., primary, Liu, H., additional, Zhong, Y., additional, Zhang, Y., additional, Li, R., additional, Sun, X., additional, Kpetsu, J.-B., additional, Côté, C., additional, Jedrzejowsk, P., additional, Sarkissian, Andranik, additional, Merel, P., additional, Laou, P., additional, Paradis, S., additional, and Désilets, S., additional

Published
2019
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20. Catching Element Formation In The Act - The Case for a New MeV Gamma-Ray Mission: Radionuclide Astronomy in the 2020s

Author

Timmes, Fryer, F., Hungerford, C., Couture, A. L., Adams, A., Aoki, F., Arcones, W., Arnett, A., Auchettl, D., Avila, K., Badenes, M., Baron, C., Bauswein, E., Beacom, A., Blackmon, J., Blondin, J., Bloser, S., Boggs, P., Boss, S., Brandt, A., Bravo, T., Brown, E., Bruenn, P., Budtz-Jørgensen, S., Burns, C., Calder, E., Caputo, A., Champagne, R., Chevalier, A., Chieffi, R., Chipps, A., Cinabro, K., Clarkson, D., Clayton, O., Coc, D., Connolly, A., Conroy, D., Côté, C., Couch, B., Dauphas, S., Boer, N., Deibel, R. J., Denisenkov, C., Desch, P., Dessart, S., Diehl, L., Doherty, R., Domínguez, C., Dong, I., Dwarkadas, S., Fan, V., Fields, D., Fields, B., Filippenko, C., Fisher, A., Foucart, R., Fransson, F., Fröhlich, C., Fuller, C., Gibson, G., Giryanskaya, B., Görres, V., Goriely, J., Grebenev, S., Grefenstette, S., Grohs, B., Guillochon, E., Harpole, J., Harris, A., Harris, C., Harrison, J. A., Hartmann, F., Hashimoto, D., Heger, M., Hernanz, A., Herwig, M., Hirschi, F., Hix, R., Höflich, R. W., Hoffman, P., Holcomb, R., Hsiao, C., Iliadis, E., Janiuk, C., Janka, A., Jerkstrand, T., Johns, A., Jones, L., José, S., Kajino, J., Karakas, T., Karpov, A., Kasen, P., Kierans, D., Kippen, C., Korobkin, M., Kobayashi, O., Kozma, C., Krot, C., Kumar, S., Kuvvetli, P., Laird, I., Laming, A., Larsson, J. M., Lattanzio, J., Lattimer, J., Leising, J., Lennarz, M., Lentz, A., Limongi, E., Lippuner, M., Livne, J., Lloyd-Ronning, E., Longland, N., Lopez, R., Lugaro, L. A., Lutovinov, M., Madsen, A., Malone, K., Matteucci, C., Mcenery, F., Meisel, J., Messer, Z., Metzger, B., Meyer, B., Meynet, B., Mezzacappa, G., Miller, A., Miller, J., Milne, R., Misch, P., Mitchell, W., Mösta, L., Motizuki, P., Müller, Y., Mumpower, B., Murphy, M., Nagataki, J., Nakar, S., Nomoto, E., Nugent, K., Nunes, P., Shea, F. O., Oberlack, B., Pain, U., Parker, S., Perego, L., Pignatari, A., Pinedo, M., Plewa, G. M., Simon Portegies Zwart, Poznanski, S. F., Priedhorsky, D., Pritychenko, W., Radice, B., Ramirez-Ruiz, D., Rauscher, E., Reddy, T., Rehm, S., Reifarth, E., Richman, R., Ricker, D., Rijal, P., Roberts, N., Röpke, L., Rosswog, F., Ruiter, S., Ruiz, A. J., Savin, C., Schatz, D. W., Schneider, H., Schwab, D., Seitenzahl, J., Shen, I., Siegert, K., Sim, T., Smith, S., Smith, D., Smith, K., Sollerman, M., Sprouse, J., Spyrou, T., Starrfield, A., Steiner, S., Strong, A., Sukhbold, A. W., Suntzeff, T., Surman, N., Tanimori, R., The, T., S Thielemann, L., K Tolstov, F., Tominaga, A., Tomsick, N., Townsley, J., Tsintari, D., Tsygankov, P., Vartanyan, S., Venters, D., Vestrand, T., Vink, T., Waldman, J., Wang, R., Wang, L., Warren, X., West, M., Wheeler, C., Wiescher, J. C., Winkler, M., Winter, C., Wolf, L., Woolf, B., Woosley, R., Wu, S., Wrede, J., Yamada, C., Young, S., Zegers, P., and Zingale, R.

Subjects
Physics, education.field_of_study, 010308 nuclear & particles physics, Astrophysics::High Energy Astrophysical Phenomena, Population, Gamma ray, Astronomy, Cosmic ray, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, Galaxy, Interstellar medium, Supernova, Neutron star, Nucleosynthesis, 0103 physical sciences, education, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics
Abstract

Gamma-ray astronomy explores the most energetic photons in nature to address some of the most pressing puzzles in contemporary astrophysics. It encompasses a wide range of objects and phenomena: stars, supernovae, novae, neutron stars, stellar-mass black holes, nucleosynthesis, the interstellar medium, cosmic rays and relativistic-particle acceleration, and the evolution of galaxies. MeV gamma-rays provide a unique probe of nuclear processes in astronomy, directly measuring radioactive decay, nuclear de-excitation, and positron annihilation. The substantial information carried by gamma-ray photons allows us to see deeper into these objects, the bulk of the power is often emitted at gamma-ray energies, and radioactivity provides a natural physical clock that adds unique information. New science will be driven by time-domain population studies at gamma-ray energies. This science is enabled by next-generation gamma-ray instruments with one to two orders of magnitude better sensitivity, larger sky coverage, and faster cadence than all previous gamma-ray instruments. This transformative capability permits: (a) the accurate identification of the gamma-ray emitting objects and correlations with observations taken at other wavelengths and with other messengers; (b) construction of new gamma-ray maps of the Milky Way and other nearby galaxies where extended regions are distinguished from point sources; and (c) considerable serendipitous science of scarce events -- nearby neutron star mergers, for example. Advances in technology push the performance of new gamma-ray instruments to address a wide set of astrophysical questions.

Published
2019

26. Poster display II clinical general

Author

Gurgenyan, S., Vatinyan, S., Nikogosyan, K., Edilyan, L., Chobanyan, B., Lacourcière, Y., Marcel Dumont, M., Lefebvre, J., Poirier, L., Côté, C., Peix, A., Alonso, O., Chae, I., Chung, J., Gutierrez, C., Kropp, J., Onsel, C., Silvasi, I., Llerena, L., Padhy, A., Garcia-Barreto, D., Trapaga, A., Asen, L., Infante, O., Ponce, F., Cabrera, L., Valiente, J., Tornes, F., Guerrero, I., Zayas, R., ones, M., Castro, J., Fayad, Y., Carrillo, R., Paz, A., Mehlsen, J., Hædersdal, C., Daou, D., Benada, A., Lebtahi, R., Idy-Peretti, I., Guludec, D., Coaguila, C., Vilain, D., Leenhardt, A., Heinicke, N., Benesch, B., Kaiser, T., Seegmüller, M., Schönberger, J., Eilles, C., Riegger, G., Holmer, S., Luchner, A., Kouris, N., Kontogianni, D., Goranitou, G., Sifaki, M., Kalkandi, E., Grassos, H., Papoulia, E., Babalis, D., Moralidis, E., Spyridonidis, T., Arsos, G., Karakatsanis, K., Karatzas, N., Parameswaran, R., Sundaram, P., Padma, S., Haridas, K., Zachariah, M., Kumar, S., Feola, M., Leonardi, G., Peano, S., Bianchi, A., Dutto, P., Guala, E., Biggi, A., Uslenghi, E., Filardi, P., Pace, L., Dellegrottaglie, S., Corrado, L., Cafiero, M., Camerino, R., Maglione, A., Polimeno, M., Zarrilli, A., Chiariello, M., Giorgetti, A., Gimelli, A., Marini, C., Schluter, M., Kusch, A., D'Aragona, I., Marzullo, P., Stanislao, M., Zanco, P., Inglese, E., Bertelli, P., Valle, G., Tassone, F., Pepino, R., Francini, A., Garrone, O., Occelli, M., Merlano, M., Florimonte, L., Pagani, L., Piatti, L., Butti, I., Maffioli, L., Casorelli, E., Dottore, F., Gentili, G., Agostini, M., Pieri, P., Milan, E., Giubbini, R., Mazzanti, M., Serenelli, M., Perna, G., Ferro, A., Duilio, C., Santomauro, M., Salvatore, M., Cuocolo, A., Bertagna, F., Bosio, G., Terzi, A., Paghera, B., Kaneta, T., Otani, H., Hakamatsuka, T., Fukuda, H., Nakazato, R., Moroi, M., Kunimasa, T., Furuhashi, T., Sugi, K., Yasuhi, W., Akihiro, S., Yukawa, A., Ryu, K., Kimio, T., Yasuhiko, T., Nariaki, E., Yasunori, W., Akashi, Y., Musha, H., Kida, K., Itoh, K., Inoue, K., Kawasaki, K., Hashimoto, N., Nakazawa, K., Miyake, F., Fukuzawa, S., Ozawa, S., Inagaki, M., Sugioka, J., Okino, S., Matsuo, S., Matsumoto, T., Nakae, I., Masuda, D., Horie, M., Mori, Y., Takahashi, K., Masai, M., Kawasaki, D., Kanemori, T., Okuda, S., Tanabe, K., Ohyanagi, M., OKuda, S., Toyama, T., Hoshizaki, H., Seki, R., Isobe, N., Kawaguchi, R., Oshima, S., Taniguchi, K., Nakagawa, K., Sekine, T., Yamazaki, M., Komuro, I., Kim, K., Teramoto, N., Jino, H., Ohta, Y., Watabe, H., Hayashi, T., Iida, H., Nishimura, T., Nagae, A., Morishima, K., Shigeyama, T., Shimoyama, K., Yoshino, H., Kawai, Y., Jeong, S., Lee, J., Seo, J., Bae, J., Ahn, B., Chae, S., Lee, K., Cho, I., Chun, K., Won, K., Lee, H., Hong, G., Park, J., Shin, D., Kim, Y., Shim, B., Pavlovic, J., Peovska, I., Vavlukis, M., Gorceva, D., Majstorov, V., Alexanderson, E., Meave, A., Ricalde, A., Teresinska, A., Sliwinski, M., Konieczna, S., Szymanska, M., Hendzel, P., Juraszynski, Z., Debski, A., Szumilak, B., Kostkiewicz, M., Wilkolek, P., Pasowicz, M., Klimeczek, P., Pieniazek, P., Przewlocki, T., Pieculewicz, M., Tracz, W., Szot, W., Trebacz, J., Zmudka, K., Podolec, P., Dziuk, M., Kazmierczak, A., Kot, E., Pietrzykowski, J., Cholewa, M., Coutinho, M., Correia, M., Cantinho, G., Conceição, I., Bernardes, A., Silva, A., Gaspar, F., Cunha, J., Lourenço, C., Roque, C., Ferrer-Antunes, A., Ferreira, M., Providência, L., Lima, J., Abreu, A., Castillejos, L., Henriksson, I., Oliveira, L., Rosário, L., Geão, A., Pereira, E., Colarinha, P., Romero-Farina, G., Candell-Riera, J., Aguadé-Bruix, S., Leon, G., Caresia, A., Mila-Lopez, M., Garcia-Alonso, C., Pifarre-Montaner, P., Negre-Buso, M., Castell-Conesa, J., Mestre-Fusco, A., Porta-Biosca, F., Muxi, A., Paredes, P., Ortin, J., Duch, J., Diaz-Infante, E., Fuertes, S., Orus, J., Mont, L., Pons, F., Pollack, C., Hellermann, J., Namdar, M., Siegrist, P., Koepfli, P., Bartenstein, N., Schurr, U., Jenni, R., Kaufmann, P., Hassad, R., Hamami, H., Sellem, A., Brahim, H., Caglar, M., Mahmoudian, B., Aytemir, K., Kahraman, S., Arýcý, M., Kabakcý, G., Karabulut, E., Akincioglu, C., Berman, D., Nishina, H., Hayes, S., Kavanagh, P., Friedman, J., Slomka, P., Germano, G., Entok, E., Cavusoglu, Y., Vardareli, E., Timuralp, B., Cheetham, A., Naylor, V., Ghiotto, F., McGhie, J., Al-Housni, M., Kelion, A., Hutchings, F., Hinton-Taylor, S., Birkbeck, P., Thatikonda, S., Feldkamp, M., Rosamond, T., Raza, M., Panjrath, G., Haider, A., Jain, D., Yang, A., Schumacher, R., Reynolds, J., Clark, E., Speiser, D., Schindel, M., Hackney, T., Vacek, J., Jindal, V., Dim, U., Hamburg, L., Mouradian, V., Nichols, K., Akinboboye, O., Snyder, K., Polepalle, D., DePuey, G., Khattak, H., Friedman, M., Thompson, L., Thompson, R., McGhie, A., Moser, K., O'Keefe, J., Fritsch, N., Bateman, T., Mut, F., Vidal, I., Rener, A., Nuñez, M., Alvarez, B., and Beretta, M.

Published
2018

29. Plasma Physics with Ultra-Short and Ultra-Intense Laser Pulses

Author

Johnston, T. W., primary, Beaudoin, Y., additional, Chaker, M., additional, Côté, C. Y., additional, Kieffer, J. C., additional, Matte, J. P., additional, Pépin, H., additional, Chien, C. Y., additional, Coe, S., additional, Mourou, G., additional, and Umstadter, D., additional

Published
1993
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30. Optical emission spectroscopy of microwave-plasmas at atmospheric pressure applied to the growth of organosilicon and organotitanium nanopowders.

Author

Kilicaslan, A., Levasseur, O., Roy-Garofano, V., Profili, J., Moisan, M., Côté, C., Sarkissian, A., and Stafford, L.

Subjects
ARGON plasmas, EMISSION spectroscopy, ATMOSPHERIC pressure, ORGANOSILICON compounds, ORGANOTITANIUM compounds, ELECTROMAGNETIC surface waves, SPECTRUM analysis
Abstract

An atmospheric-pressure plasma sustained by an electromagnetic surface wave (SW) in the microwave regime combined with a bubbler/flash evaporator for the injection of liquid precursors was used to produce organosilicon and organotitanium nanopowders. Following the addition of hexamethyldisiloxane (HMDSO) vapors in the nominally pure argon plasma, optical emission spectra revealed the apparition of strong C2 molecular bands along with Si and Balmer H emission lines. Such features were not observed in our atmospheric-pressure Ar/HMDSO discharges controlled by dielectric barriers, indicating that microwave plasmas are characterized by much higher fragmentation levels of the precursors due to much higher electron densities. Emission spectra from the Ar/HMDSO SW plasma further showed a high-intensity continuum, the intensity of which decreased with time as powders started to form on the discharge tube walls. In presence of titanium isopropoxide (TTIP) vapors in the nominally pure Ar plasma, the emission was dominated by Ar and Ti lines, with no trace of carbon and no continuum. Fourier-Transform Infrared (FTIR) Spectroscopy of the powders formed in Ar/HMDSO plasmas showed very strong Si-(CH3)x and O-Si-(CH3)x bands, which is consistent with the formation of silicon oxycarbide. Transmission Electron Microscopy (TEM) further showed tube and sheet-like nanofeatures as well as larger structures consisting of agglomerated primary clusters. On the other hand, introduction of O2 in Ar/HMDSO plasmas produced only round-like nanoparticles with strong Si-O-Si bands and no trace of carbon, consistent with the formation of SiOx. The average size of the silica nanoparticles was 50 nm. FTIR spectra of powders formed in Ar/TTIP plasmas showed strong Ti-O signals, even without the addition of O2 in the gas phase. Corresponding TEM analysis showed nano- and agglomerated features comparable to those obtained in Ar/HMDSO although the average size of the titanate nanoparticles was smaller (10 nm). This set of data indicates that SW plasmas represent a promising parametric tool not only to achieve nanopowders with tailored properties for applications, but also for fundamental studies of nanodusty plasmas at atmospheric-pressure. [ABSTRACT FROM AUTHOR]

Published
2014
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38. P003 Implementation of High Throughput Parallel Sequencing in a Diagnostic Setting: Multiplexed Amplicon Sequencing of the Breast Cancer Genes BRCA1 and 2

Author

Zogopoulos G, Tomi Pastinen, Sivanandan K, Vaca F, Kinoshita T, Johannes B, Leguis E, Jansen-van der Weide M, Learn L, Godlewski D, Ed Saunders, Montserrat Rué, Vaisman A, de Bock G, Ángel Segura, Sabbaghian N, Mohammad Amin Kerachian, Pelletier S, Metcalfe K, Lilge L, Stockle E, Cheng S, Burger C, Woike A, Michelle Guy, Ragone A, Y. J. Bignon, Bronkhorst Y, Patricia N. Tonin, Lima M, Mieke Kriege, Karsan A, Zweemer R, Prady C, Beattie M, Panchal S, Kathleen Claes, van Zon P, Diane Provencher, Ummels A, Kang I, Shumak R, Arcusa Â, Yosr Hamdi, Alonso Mc, Dolman L, Houssami N, Olivier Delattre, Yannick Bidet, Claude Houdayer, Mercedes Durán, Ganschow P, Isabel Chirivella, Domingo S, Rebsamen M, Giustina Simone, Orland Diez, Chapman J, An tSaoir C, Jeanna McCuaig, Blayney J, Bosdet I, Treacy R, Esther Darder, Ando J, Luc Dehaspe, García-Casado Z, Duffy J, Harkin D, Z Kote-Jarai, Kasamatsu T, Ulf Kristoffersson, Membrez, Priston M, Noreau-Heisz D, Trivedi A, Begoña Graña, Ghadirian P, Ashuryk O, Consol López, Wenzel L, Vogel R, Joseph G, Poll A, Kennedy R, Patton S, Pérez C, Mónica Cornet, Panighetti A, Cassart P, Burke K, Mes-Masson A, Llacuachaqui M, Marc Tischkowitz, Wong N, Arcand S, Kotsopoulos J, Meschino W, Hall A, Marles S, Docking R, Haroun I, Marie Plante, Rachel Laframboise, Daniel Sinnett, Luce J, Sekiguchi I, Edenir Inêz Palmero, de Winter J, Christopher J. Lord, Hamel N, Pruski-Clark J, Lee D, Rusnak A, Carson N, Marta Santamariña, Knoppers B, Oakhill K, Bruce R. Rosen, Pierre O. Chappuis, Bruce Poppe, Stanislaw C, Catts Z, Brood M, van der Wall E, Yip C, Christine Walsh, Hoodfar E, Pressman A, Andrulis I, Alicia Barroso, D. Leongamornlert, Gillian Mitchell, Akira Hirasawa, Shen Z, Sameer Parpia, Horgan M, van Echtelt J, Chun K, Lubinski J, Rebecca Sutphen, Terespolsky D, Richard D, McDyer F, Floquet A, Lambo R, Bathurst L, Brown G, Kidd M, Nicolas Sevenet, Mourits M, Vencken P, Tatiana Popova, Garcia N, Armel S, van Amstel H, Valentini A, Ellen Warner, Hofland N, Hanna D, Kim J, Osann K, Enmore M, Loranger K, Sulivan I, J. Oliveira, Meijers H, Jansen R, Edmundo Carvalho Mauad, Kirkpatrick R, Danilo V Viana, Ian G. Campbell, Mil S, E J Sawyer, J. Balmaña, Samra Turajlic, Graham G, Alonso C, Inanc Birol, Sinclair F, van Tuil M, Pascual Bolufer, Micheli R, Andrew R. Green, Junyent N, Whittaker J, Monnerat C, Rhéaume J, Livingston D, Chan S, L. Ramadan, Lee R, Katarzyna Durda, De Leeneer K, Grados C, Côté C, Kyle B. Matchett, Robert Winqvist, Bonner D, Brunella Pilato, Mohd Taib N, Judy Garber, Kleiderman E, Murakami S, Sharifi N, Kimberley Hill, Desbiens C, Robert Royer, Jasperson K, Hsieh S, De Summa S, Dominique Stoppa-Lyonnet, de Lima J, Stuart McIntosh, Shakeri M, Wendy Kohlmann, Albert-Green A, de Hullu J, Pasick R, Avard D, Pathania S, van der Groep P, Laura Fachal, Bruno Zeitouni, Susan M. Domchek, Davey S, Richard Marais, Powell C, Hans J. J. P. Gille, Greenberg R, Kamata H, Cina, Gaarenstroom K, Lakhal Chaieb M, Kavanagh L, Gaelle Benais-Pont, Sun P, Jansen L, Matthew Parker, Barjhoux L, Russ H, Simon J. Furney, Willems A, Robb L, David E. Goldgar, Young S, Natalia Campacci, Mark G. Thomas, Doug Easton, Klugman S, Barrault M, Calvo N, Adriana C. Flora, Littell R, Narod S, Fragoso, N. Bosch, Finch A, Paul M. Wilkerson, Teo S, Tomasz Huzarski, Manuel Salto-Tellez, Moseley M, Davis S, Olga M. Sinilnikova, Iturbe A, Joan Brunet, Tierney M, Tsai E, Navarro de Souza A, Leclerc M, Lorenzo Manti, Gutiérrez-Enríquez S, Milewski B, Simon S. McDade, Kaplan C, Buckley N, Eva Esteban-Cardeñosa, Richter S, Shimizu C, Li J, Elena Castro, Iwanka Kozarewa, Harley I, Atocha Romero, Carlos E. Andrade, Carole Verny-Pierre, Barouk E, Vian D, Montserrat Baiget, Chan J, Sandra Bonache, Andrew Y Shuen, van der Merwe N, Kaklewski K, Mohar A, Tamura C, Heale E, Rooyadeh M, van Asperen C, Gemma Llort, Alan Mackay, Denroche R, Seelaus C, Zbuk K, McCluggage W, van der Luijt R, Maaike P.G. Vreeswijk, Edelweiss M, Crossan G, Arseneau J, Ambus I, Verheul H, Rodrigo Augusto Depieri Michelli, Juul T. Wijnen, Gross-Lester J, Britta Weigelt, Pedro Pérez-Segura, Richard A. Moore, Cornelissen C, Larouche G, McAlpine J, Daniel Nava Rodrigues, Trim L, Furnival J, Elser C, Muszyńka M, Adriana Lasa, Tuya Pal, Greuter. M, Ng K, Dorval M, Bresee C, Reimnitz G, Gaëtan MacGrogan, Perry Maxwell, Barnadas A, Hwang E, Powell B, Knapke S, Griskevicius. L, Alvarez R, Mester J, Anne-Bine Skytte, Eladio Velasco, Vidal S, Australie K, Leunen K, Ben-Yishay M, Van Houdt J, Phuah S, Amy E Taylor, Pinto R, Fonseca T, Champine M, Gammon A, Hollema H, Menko F, Feng B, David Olmos, Chong G, Tomasz Byrski, Patrick J. Morrison, Gregoire J, André Lopes Carvalho, Don B. Plewes, Rabeneck L, Carrol J, Alan Ashworth, Terlinge A, A Jakubowska, Odette Mariani, Setareh Moghadasi, Reitsma W, Rothenmund H, Herrera L, Anna Tenés, Angel Izquierdo, Asunción Torres, Stawicka M, Goh C, Hirst M, Drummond J, Osorio A, Ostrovsky R, Jeffrey N. Weitzel, Gareth W. Irwin, Fehniger J, Sugano K, Spriggs E, Dęniak T, Volenik A, Thorne H, Piccinin C, Amie Blanco, Jinno H, Robert A. Holt, Stephen B. Fox, Julia J. Gorski, Gilpin C, Herschorn S, Vega A, E. Page, Hamet P, McKenna D, Fabrice Bonnet, Yoshida T, Kienan I. Savage, Petzel S, Elizabeth Bancroft, Schneider S, Warwick L, Stewart S, William D. Foulkes, Colizza K, Bell K, Demsky R, Malgorzata Tymrakiewicz, Caldés T, Fons G, Bowen D, Côté S, Clouston D, Kitagawa Y, Gordon Glendon, Jenny Lester, Kinney A, Nelson E, Silke Hollants, Macrae L, Cajal T, Andrew J. Mungall, Ferrell B, Creighton B, Bressler L, Uy P, Makishima K, Haffaf Z, Ramūnas Janavičius, Einstein G, Zakalik D, Chiarelli A, Cantu D, Croce S, Kalloger S, Lin F, Ian O. Ellis, Benedito Mauro Rossi, R A Wilkinson, Mulligan J, Murphy J, Vadaparampil S, Smith E, Slangen B, Loiselle C, Iqbal J, Palma L, Cooper K, Jorge S. Reis-Filho, Chen. L, Quinten Waisfisz, Haneda E, Banks P, Vermeulen K, Visser B, Montalbán G, McCabe N, Honeyford J, Naseri S, Ng J, Ali A, Sandrine Viala, Mensa I, Kamarainen O, Guerra C, Mazzola E, David A. Schwartz, Marjanka K. Schmidt, Simon R, Fergus J. Couch, Margreet G. E. M. Ausems, Anne Vincent-Salomon, Olinski R, Zewald R, Moreno R, Semple J, McPherson J, Lamers E, Kharbanda A, Kessler L, Biemans D, Au A, Bordeleau L, Jean Feunteun, Mar Infante, Mullan P, Rudaitis, Molenda A, Rachael Natrajan, Pawar, Boman B, Kok T, Andrew A. Brown, Geller M, Monfared N, Bart J, Murata P, Crawford N, Butterfield Y, Bargalló J, Katherine L. Tucker, Cook-Wiens G, Rhodes A, Elodie Manié, Rubio E, Oram L, Shandiz F, Hayden R, Crawford B, Parmigiani G, Harkin P, Müller C, Grant M, Maryou B. Lambros, Thong M, Grzegorz Sukiennicki, Wouts J, Haddock P, Ramon y Cajal T, Kenneth C. Anderson, Michel Longy, Batiste W, Carroll J, Matte C, Hojyo T, Zhao Y, Caroline Seynaeve, Wai P, Simard J, Hurley K, Bolton D, Karlan B, Javier Benítez, Miriam Masas, Tołczko-Grabarek A, de Dueñas E, Geneviève Michils, Moncoutier, Nancy Uhrhammer, MacDonald D, Keyserlingk J, Osher D, Gilks C, Christopher T. Elliott, Scharf L, Gabram-Mendola S, Grondin K, Dohany L, van Diest P, Joris Vermeesch, Jan C. Oosterwijk, M’Baïlara K, DePuit M, Jacek Gronwald, Stefania Tommasi, de la Hoya M, Bouchard K, Black L, Lui M, Soucy P, Rosalind A. Eeles, Gert Matthijs, Graham T, Andrea Eisen, Bacha O, Alvaro N.A. Monteiro, Yoon S, Caron T, Smith D, Marc-Henri Stern, Hampson E, Kurz R, Gaasbeek W, Mundt E, Angela Velasco, Quinn J, Jocelyne Chiquette, Marquez T, Adam B. Murphy, Bakker J, Neus Gadea, Anita Grigoriadis, Aoki D, Dean S, Looi L, Paradiso A, Agostina Stradella, K. Govindasami, Lovell N, Eva Tomiak, Siesling S, Belanger M, Feilotter H, Knight J, Emmanuel Barillot, Huang M, Raquel Andrés, Kang P, Somerman C, Gackowski D, Rimel B, Nakamura S, McClellan K, Barrros E, Henriette Roed Nielsen, Rui Manuel Reis, Greening S, Ayme A, Carmen Guillen, de Vries E, and Katarzyna Jaworska

Subjects
Oncology, Education and Communication, medicine.medical_specialty, endocrine system diseases, medicine.diagnostic_test, business.industry, Psycho-Oncology, medicine.disease, Meeting Abstracts, Transcriptome, Basic Research, Clinical Management, Germline mutation, Breast cancer, Applied Research, Internal medicine, Mutation (genetic algorithm), medicine, Genetic Counselling, Human genome, skin and connective tissue diseases, business, Ovarian cancer, Comparative genomic hybridization, Fluorescence in situ hybridization
Abstract

Background: Germline mutation screening of BRCA1 and BRCA2 genes is performed in suspected familial breast cancer cases, but a causative mutation is found in only 30% of patients. The development of additional methods to identify good candidates for BRCA1 and BRCA2 analysis would therefore increase the efficacy of diagnostic mutation screening. With this in mind, we developed a study to determine molecular signatures of BRCA1—or BRCA2—mutated breast cancers. Materials and Methods: Array-cgh (comparative genomic hybridization) and transcriptomic analysis were performed on a series of 103 familial breast cancers. The series included 7 breast cancers with a BRCA1 mutation and 5 breast cancers with a BRCA2 mutation. The remaining 91 cases were obtained from 73 families selected on the basis of at least 3 affected first-degree relatives or at least 2 affected first-degree relatives with breast cancer at an average age of 45 years. Array-cgh analyses were performed on a 4407 BAC-array (CIT-V8) manufactured by IntegraGen. Transcriptomic analyses were performed using an Affymetrix Human Genome U133 Plus 2.0 chip. Results: Using supervised clustering analyses we identified two transcriptomic signatures: one for BRCA1-mutated breast cancers consisting of 600 probe sets and another for BRCA2-mutated breast cancers also consisting of 600 probes sets. We also defined cgh-array signatures, based on the presence of specific genomic rearrangements, one for BRCA1-mutated breast cancers and one for BRCA2-mutated breast cancers. Conclusions: This study identified molecular signatures of breast cancers with BRCA1 or BRCA2 germline mutations. Genes present in these signatures could be exploited to find new markers for such breast cancers. We also identified specific genomic rearrangements in these breast cancers, which could be screened for in a diagnostic setting using fluorescence in situ hybridization, thus improving patient selection for BRCA1 and BRCA2 molecular genetic analysis.

Published
2009

46. Abstracts

Author

Bertram, S. G., Koch, J. P., Dubbin, J. D., Maggisano, R., McKenzie, R. N., Thomson, I. R., Hudson, R. J., Torchia, M., Rosenbloom, M., Wynands, J. E., Ansley, D. M., Bent, J. M., Ramsay, J. G., Whalley, D. G., Ralley, F. E., Carli, F., Smedstad, K. G., Morison, D. H., McCanoll, S. M., Cartwright, P., Weeks, S. K., Donati, F., Michoud, M. C., Amyot, R., Jeanneret-Grosjean, A., Couture, J., McDonald, N. J., Lavelle, P., Harpin, R. P., Gallacher, W. N., Baker, J. P., Kitts, J. B., Veilleux, L. J., McBurney, R., Martineau, R., Bissonnette, B., Lerman, J., Lim, G., Chung, D. C., Plourde, G., Hardy, J. F., Bany, P. P., Tardif, L., Labrecque, P., Archer, D. P., Tyler, J., Meyer, E., Trop, D., Brown, S. C., Lam, A. M., Manninen, P. H., Katz, J. M., Abou-Madi, M., Abou-Madi, N., Woodcock, T. E., Murkin, J. M., Farrar, J. K., Tweed, W. A., Guiraudon, G., McKenzie, F. N., Nadeau, S. G., Robblee, J. R., Mensink, F. J., Kozody, R., Kehler, C. H., Wade, J. G., Bevan, D. R., Baxter, M., Bevan, J. C., McCarroll, S. M., Antzaka, C., McCready, D., Lahoud, J., O’Brien, D. J., Moriarty, D. C., Hope, C. E., Liberman, B. A., Skala, R., Lam, A., Gelb, A., Gelb, A. W., Steinberg, G. K., Neto, A. Rassi, Bellefleur, M., Layon, J., Gallagher, T. J., Berman, L. S., Davidson, D. D., Duke, P. C., Parrott, J., Palahniuk, R. J., Cunningham, A. J., Casey, W., Hannon, V., Litak, C., Ansley, D., Fullerton, H., Ripley, A. R., Sami, M. H., Harrison, L., Robbins, G. R., Fullerton, H. A., Nathan, H. J., Arvieux, C. C., Foëx, P., Ryder, W. A., Jones, L. A., Moffitt, E. A., Mclntyre, A. J., Imrie, D. D., Kinley, C. E., Sullivan, J. A., Murphy, D. A., Cannon, J. E., Morris, A., Robbins, R., Ramsay, J. R., Blaise, G., Sill, J. C., Nugent, M., Vanhoutte, P. M., Moote, C. A., Skinner, M. I., Grace, D. M., Knill, R. L., Johnston, R. G., Anderson, B. J., Noseworthy, T. W., Shustack, A., Forbes, R. B., Kumar, V., Mitros, F. A., Johnson, G. M., Coleman, P., Roth, S., Macnab, M. S. P., Gelb, A. W., Fuller, J., Karlik, S., Diamond, C., Hannallah, R. S., Patel, R. I., Ehrenpreis, M. B., Soliman, I. E., Cunliffe, M., Britt, B. A., Kapsten, J. E., Broadman, L. M., Norrie, W. C., Mundy, G. L., Belman, A. B., Anderson, K. D., Guzetta, P. C., Sharpe, T. D., Goresky, G. V., Sabourin, M. A., Ahuja, B., Eustis, S., Smith, D., Lenis, S., Archer, D., Ravussin, P., Bélisle, S., Saint-Germain, J. F., Chung, F., Meier, R., Lebrun, M., Dubé, S., Côté, C., Byrick, R. J., Howie, G., Kay, J. C., Waddell, J. P., and Mullen, B.

Published
1986
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48. Behaviour of enteric micro-organisms in Canadian and French swine manure treatments

Author

Pourcher, A.M., Aktouche, N., Côté, C., Rousseau, Philippe, GODBOUT, STEPHANE, Martinez, José, Irstea Publications, Migration, Gestion environnementale et traitement biologique des déchets (UR GERE), Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF), IRDA QUEBEC CAN, Partenaires IRSTEA, and Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)

Subjects
[SDE] Environmental Sciences, CANADA, [SDE]Environmental Sciences, FRANCE, INDICATEURS, HYGIENISATION
Abstract

Une étude franco canadienne a été menée dans 5 élevages porcins afin de comparer l'efficacité de filières de traitements du lisier sur la survie des germes indicateurs et des pathogènes dans les sous-produits liquides. Trois technologies ont été évaluées au Québec. Le procédé Biofertile comprend une séparation physique du lisier, une digestion aérobie et un traitement électrochimique. Le procédé Biosor consiste en une séparation physique du lisier suivie d'une bio-filtration. La technologie Bioterre correspond à une digestion anaérobie à basse température. Deux technologies ont été évaluées en France. Le procédé Valetec consiste en une séparation physique du lisier, une digestion aérobie et une séparation par sédimentation. La technologie Balcopure correspond à un traitement physico-chimique comprenant une centrifugation et une volatilisation de l'ammoniac par stripping après addition de chaux. Les micro-organismes recherchés sont les entérocoques, Escherichia coli, Salmonella spp, Clostridium perfringens et Cryptosporidium spp. La séparation physique de la phase liquide a eu un impact important sur E. coli pour les procédés Biofertile and Biosor avec un abattement estimé à 1 à 2 unités logarithmiques. L'effet de la centrifugation est plus faible pour les procédés Valetec et Balcopure dont l'abattement est inférieur à 0,5 unités logarithmiques. A l'exception du procédé Bioterre, les concentrations moyennes en E. coli dans les lisiers bruts comprises entre 103 et 105 NPP /g sont inférieures à 30 NPP/g après la dernière étape du traitement. Les digestions aérobies et anaérobies ont entraîné une réduction de 2 unités logarithmiques de E. coli. Le comportement des entérocoques est très proche de celui de E. coli. En revanche, l'effet des traitements est nettement moins marqué pour Clostridium perfringens. Salmonella a été détectée dans l'ensemble des lisiers bruts mais à une fréquence variant de 10 à 100% selon les élevages. Malgré l'obtention d'un abattement des indicateurs de traitement (E. coli et les entérocoques), la présence de Salmonella et de Cryptosporidium dans une partie des lisiers traités indique l'existence d'un risque sanitaire.

Published
2006

50. Total and infectious Cryptosporidium oocyst and total Giardia cyst concentrations from distinct agricultural and urban contamination sources in Eastern Canada

Author

Lalancette, C., Généreux, M., Mailly, J., Servais, Pierre, Côté, C, Michaux, A., Di Giovanni, G., Prévost, Martine, Lalancette, C., Généreux, M., Mailly, J., Servais, Pierre, Côté, C, Michaux, A., Di Giovanni, G., and Prévost, Martine

Abstract

Cryptosporidium and Giardia (oo)cyst concentrations are frequently used for assessing drinking water safety. The widely used USEPA Method 1623 provides total counts of (oo)cysts, but may not be accurate for human health risk characterization, since it does not provide infectivity information. The total counts and infectious fraction of Cryptosporidium oocysts and the total counts of Giardia cysts were assessed in major fecal pollution sources. Fresh calf and cow feces, their manure, and the discharge point were sampled in a small rural sub-watershed (n = 20, 21, 10, 10). Median concentrations for total (oo)cysts were higher in calves (333 oocysts g(-1); 111 cysts g(-1)) than in cows (52 oocysts g(-1); 7 cysts g(-1)). Infectious oocysts were found in 17 (7%) of the samples and none were found in manure or at the discharge point. Urban sources were sampled in the influent and effluent (n = 19, 18) of two wastewater treatment plants. Peak concentrations were 533 oocysts L(-1) and 9,010 cysts L(-1) for influents and 89 oocysts L(-1) and 472 cysts L(-1) for effluents. Infectious oocyst fractions varied from below the detection limit to 7-22% in the effluent and influent respectively. These infectious fractions are significantly lower than those currently used for quantitative microbial risk assessment estimates., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2012

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