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Este ensayo es producto de una investigación en el campo de la teoría e historia del arte y se concentra en el análisis de la pintura inédita Escena de dormitorio (c.1985-86) del destacado escritor y pintor chileno Adolfo Couve Rioseco (1940-1998). La obra salió a la luz en 2021, y su estudio no solo permite abordar problemas relativos a autoría, data, técnica y gestos pictóricos, sino también comentar los espacios domésticos y las relaciones familiares del autor. Sobre todo, permite profundizar en sus filiaciones visuales; en este caso puntual, su interés por óleos tales como Jeremías lamentando la destrucción de Jerusalén (1630) de Rembrandt van Rijn; una de las cuatro versiones de El muchacho del chaleco rojo (c.1889-90) de Paul Cézanne, y las naturalezas muertas del italiano Giorgio Morandi, a partir de los cuales probablemente Couve construyó el cuadro hasta ahora no documentado que aquí se somete a escrutinio.

O texto pretende explorar a constituição do sentido de uma obra, relacionando-a com uma noção de vida expandida para além do âmbito pessoal de um artista. Apresentando o paradoxo da liberdade, tal como aparece no texto de Merleau-Ponty dedicado a Cézanne, quero explorar a tensão entre necessidade e liberdade, e a imprevisibilidade nascida nas possibilidades de tal tensão. O sentido de uma vida e de uma obra dela nascida não têm, para Merleau-Ponty, uma explicação causal, nem recorrendo aos dados objetivos da vida de um artista, nem aos dados subjetivos de seu projeto pessoal, porque ambas as esferas fazem parte de uma única vida desenrolando-se dinamicamente em uma liberdade para além de uma noção meramente subjetivista. É na tensão entre projetos pessoais e as contingências da vida que a criação do artista se desenrola, e entre os condicionamentos e possibilidades constantemente abertas, um sentido vai se desvelando, sem rumo certo, discernível apenas em retrospecto. Encerrarei as reflexões com uma abordagem sobre a noção de “repetição criativa” proposta por Landes, tomando a expressão como fenômeno no qual o sentido nasce na tensão entre a pura repetição e a pura criação, tentando mostrar a espontaneidade e a fecundidade dos atos expressivos em suas possibilidades sempre abertas.

Background and Objectives: Psoriasis is an immune-mediated chronic inflammatory skin disorder and commonly associated with highly noticeable erythematous, thickened and scaly plaques. Deubiquitinase genes, such as tumor necrosis factor-alpha protein 3 (TNFAIP3, A20), the cylindromatosis (CYLD) and Cezanne, function as negative regulators of inflammatory response through the Janus kinase/signal transducers and activators of transcription (JAK-STAT) pathways. In this study, polymorphisms and expressions of A20, CYLD and Cezanne genes as well as immunophenotype in psoriatic patients were determined. Materials and Methods: In total, 82 patients with psoriasis and 147 healthy individuals with well-characterized clinical profiles were enrolled. Gene polymorphisms were determined by direct DNA sequencing, gene expression profile by quantitative real time-polymerase chain reaction (PCR), immunophenotype by flow cytometry, and the secretion of cytokines and cancer antigen (CA) 125 by enzyme-linked Immunosorbent assay (ELISA). Results: The inactivation of A20, CYLD and Cezanne and increased levels of TNF-α, IFN-γ and CA 125 was observed in psoriatic patients. Importantly, patients with low A20 expression had significant elevations of triglyceride and total cholesterol concentrations and higher numbers of CD13+CD117− and CD19+CD23+ (activated B) cells than those with high A20 expression. Genetic analysis indicated that all rs4495487 SNPs in the JAK2 gene, rs200878487 SNPs in the A20 gene and four SNPs (c.1584-375, c.1584-374, rs1230581026 and p.W433R) in the Cezanne gene were associated with significant risks, while the rs10974947 variant in the JAK2 gene was at reduced risk of psoriasis. Moreover, in the Cezanne gene, p.W433R was predicted to be probably damaging by the Polyphen-2 prediction tool and an AA/CC haplotype was associated with a high risk of psoriasis. In addition, patients with higher CA 125 levels than the clinical cutoff 35 U/mL showed increased levels of IFN-γ than those with normal CA 125 levels. Conclusions: A20 expression was associated with lipid metabolism and the recruitment of CD13+ CD117− and activated B cells into circulation in psoriatic patients. Besides this, the deleterious effect of the p.W433R variant in the Cezanne gene may contribute to the risk of psoriasis. [ABSTRACT FROM AUTHOR]

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Originally presented as a talk at Turner Contemporary Margate in 2014 in association with the exhibition Making Painting: Helen Frankenthaler and JMW Turner, the article explores the importance of Helen Frankenthaler's exposure to the work of Paul Cézanne in exhibitions in New York in the early 1950s for the making of her breakthrough painting Mountains and Sea in 1952 and speculates about her engagement with the work of Nicolas Poussin in her painting Eden (1956). [ABSTRACT FROM AUTHOR]

In this example of relatively long-form art writing, the writer begins by relaying an anecdote regarding a difficult interaction with an editor. As this rocks the confidence of the writer, they try to rally themselves but seeking out an almost arbitrary receptor for their art writing skills and passions. This turns out to be a concurrent exhibition of the paintings of Giorgio Morandi. The piece describes the writer's feelings, as well as the journey to the gallery, and ultimately creates a form of review or representation of the exhibition. However, the initial impulse for the piece remains and is returned to in a series of analyses of the writer's method. This includes a candid exploration of the writer's considerations of the place of judgement in their own and in contemporary art writing. Ultimately, the piece toys with the idea that, in an age of ambivalence, in which judgements all too easily seem all too harsh, it might just be the use of adjectives that are sufficient to betray an art writer's evaluation of what they are otherwise simply describing. While the initial criticism by an editor involved the concept of transcendence, the art writer takes this accusation on board and tries, again candidly, to judge themselves, and for themselves, with regard to this concept. Ultimately, they find that, far from leaning towards transcendent values in art they are in fact committed to forms of immanence. Along the way other artists, including Cezanne and De Chirico, as well as other thinkers such as Deleuze and Alfred Jarry are utilized to develop the lines of thought. Ultimately, and rather obliquely, the piece becomes a response to the editor's riposte and appears to succeed, to some extent, in re-founding the writer's confidence in their own methods and beliefs, to which they have been led by their own approach to art writing, and of course by the art itself. [ABSTRACT FROM AUTHOR]

Background and Objectives: Psoriasis is an immune-mediated chronic inflammatory skin disorder and commonly associated with highly noticeable erythematous, thickened and scaly plaques. Deubiquitinase genes, such as tumor necrosis factor-alpha protein 3 (TNFAIP3, A20), the cylindromatosis (CYLD) and Cezanne, function as negative regulators of inflammatory response through the Janus kinase/signal transducers and activators of transcription (JAK-STAT) pathways. In this study, polymorphisms and expressions of A20, CYLD and Cezanne genes as well as immunophenotype in psoriatic patients were determined. Materials and Methods: In total, 82 patients with psoriasis and 147 healthy individuals with well-characterized clinical profiles were enrolled. Gene polymorphisms were determined by direct DNA sequencing, gene expression profile by quantitative real time-polymerase chain reaction (PCR), immunophenotype by flow cytometry, and the secretion of cytokines and cancer antigen (CA) 125 by enzyme-linked Immunosorbent assay (ELISA). Results: The inactivation of A20, CYLD and Cezanne and increased levels of TNF-α, IFN-γ and CA 125 was observed in psoriatic patients. Importantly, patients with low A20 expression had significant elevations of triglyceride and total cholesterol concentrations and higher numbers of CD13+CD117− and CD19+CD23+ (activated B) cells than those with high A20 expression. Genetic analysis indicated that all rs4495487 SNPs in the JAK2 gene, rs200878487 SNPs in the A20 gene and four SNPs (c.1584-375, c.1584-374, rs1230581026 and p.W433R) in the Cezanne gene were associated with significant risks, while the rs10974947 variant in the JAK2 gene was at reduced risk of psoriasis. Moreover, in the Cezanne gene, p.W433R was predicted to be probably damaging by the Polyphen-2 prediction tool and an AA/CC haplotype was associated with a high risk of psoriasis. In addition, patients with higher CA 125 levels than the clinical cutoff 35 U/mL showed increased levels of IFN-γ than those with normal CA 125 levels. Conclusions: A20 expression was associated with lipid metabolism and the recruitment of CD13+ CD117− and activated B cells into circulation in psoriatic patients. Besides this, the deleterious effect of the p.W433R variant in the Cezanne gene may contribute to the risk of psoriasis.

Background. Polycythemia vera (PV) is characterized by increased proliferation and accumulation of erythroid and mature myeloid cells and megakaryocyte in the bone marrow and peripheral blood. The JAK2V617F mutation is present in most PV patients. Deubiquitinase (DUB) genes, including TNFAIP3 (A20), CYLD and Cezanne, function as negative regulators of inflammatory reaction through nuclear factor kappa-light-chainenhancer of activated B cells (NF-κB) signaling. Objectives. To determine single nucleotide polymorphisms (SNPs) profiling and gene expression of the DUB genes as well as the immunophenotype of PV cells. Material and methods. Seventy-seven patients with PV and 55 healthy individuals with well-characterized clinical profiles were enrolled. Gene expression profile was determined using quantitative real-time polymerase chain reaction (qRT-PCR), the immunophenotype with flow cytometry, secretion of cytokines using enzyme-linked immunosorbent assay (ELISA), and gene polymorphisms using direct DNA sequencing. Results. Inactivation of A20, CYLD and Cezanne, and increases in interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) levels, as well as the enhanced number of CD25+CD4 T, Th1 and regulatory T cells were observed in PV patients. The genetic analysis of the CYLD gene identified 11 SNPs, in which a novel W736G nsSNP in exon 15 and a SNP c.2483+6 T>G in intron 15 were observed in PV cases with the frequencies of 18.2% and 5.2%, respectively. The W736G non-synonymous SNP (nsSNP) was found to be most likely to exert deleterious effect and the intronic SNP c.2483+6 T>G was identified as aberrant splicing. Sequencing of Cezanne gene identified 7 SNPs in intron 10 and PV carriers of the SNPs had at least 2 SNPs in this gene. Importantly, PV carriers of the W736G nsSNP had multiple SNPs in CYLD, but not in A20 or Cezanne gene. Conclusions. Two identified SNPs, including the W736G nsSNP and the SNP c.2483+6 T>G, in CYLD gene might be associated with a risk of PV disease, in which the deleterious effect of the W736G nsSNP in CYLD gene could contribute to the pathogenesis of PV. [ABSTRACT FROM AUTHOR]

Aims Pathological arterial remodelling including neointimal hyperplasia and atherosclerosis is the main underlying cause for occluding arterial diseases. Cezanne is a novel deubiquitinating enzyme, functioning as a NF-кB negative regulator, and plays a key role in renal inflammatory response and kidney injury induced by ischaemia. Here we attempted to examine its pathological role in vascular smooth muscle cell (VSMC) pathology and arterial remodelling. Methods and results Cezanne expression levels were consistently induced by various atherogenic stimuli in VSMCs, and in remodelled arteries upon injury. Functionally, VSMCs over-expressing wild-type Cezanne, but not the mutated catalytically-inactive Cezanne (C209S), had an increased proliferative ability and mobility, while the opposite was observed in VSMCs with Cezanne knockdown. Surprisingly, we observed no significant effects of Cezanne on VSMC apoptosis, NF-κB signalling, or inflammation. RNA-sequencing and biochemical studies showed that Cezanne drives VSMC proliferation by regulating CCN family member 1 (CCN1) by targeting β-catenin for deubiquitination. Importantly, local correction of Cezanne expression in the injured arteries greatly decreased VSMC proliferation, and prevented arterial inward remodelling. Interestingly, global Cezanne gene deletion in mice led to smaller atherosclerotic plaques, but with a lower level of plaque stability. Translating, we observed a similar role for Cezanne in human VSMCs, and higher expression levels of Cezanne in human atherosclerotic lesions. Conclusion Cezanne is a key regulator of VSMC proliferation and migration in pathological arterial remodelling. Our findings have important implications for therapeutic targeting Cezanne signalling and VSMC pathology in vascular diseases. [ABSTRACT FROM AUTHOR]

O texto visa, contextualmente, situar Nietzsche como um precursor da fenomenologia compreendida por Merleau-Ponty menos a título de uma “doutrina” e mais como um “movimento” incoativo e inacabado. É sob esse prisma que a obra nietzschiana projeta viva audiência a alguns temas caros àquele movimento, entre eles, a interrogação acerca do mundo como mistério. Esse agenciamento encontra na ideia de profundidade um fio condutor decisivo a fim de ressignificar, em termos husserlianos, uma arqueologia da Lebenswelt enquanto regresso a uma Terra originária, algo que, ao que tudo indica, possui importantes ressonâncias não só de matrizes nietzschianas, mas cezannianas. Trata-se, enfim, de examinar em que medida a filosofia de Nietzsche e a pintura de Cézanne perfazem um rico experimento capaz de fulgurar um sentido arquétipo da natureza como abismo ou, no dizer de Merleau-Ponty, o mundo como enigma primordial ou deflagração de um Ser das profundidades.

Modulation is a fundamental concept in Simondon's thinking, directly related to individuation, sensation, perception and which allows to understand other perspectives of the inventive process. Modulation appears as a potential, potential of encounters in technical and/or aesthetic activities, which requires specific studies to understand each case. The purpose of this short essay is to observe how this concept appears in the aesthetic invention, particularly in the cinema of the Straub couple, Jean-Marie Straub and Danièle Huillet, in their meeting with Cézanne, especially in the film A Visit to the Louvre, 2003. [ABSTRACT FROM AUTHOR]

Copyright of Akademik Sanat is the property of Ankara Haci Bayram Veli University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Academic Social Science Studies is the property of Journal of Academic Social Science Studies and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Academic Social Science Studies is the property of Journal of Academic Social Science Studies and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In “Introduction to these paintings” and “Art and Morality,” Lawrence suggests that, when looking at visual art, our tendency to what he calls “kodak-vision” (one indicator of dominant mental consciousness), prevents our appreciation of new perspectives, leading us to condemn the art rather than change our viewpoint. In looking at Lawrence’s response to Cézanne’s apples this paper will consider the role visual art can play in developing a greater reverence towards the non-human, and will also look at some examples of Lawrence’s prose and poetry that shows the same intent. This will lead to the suggestion that Lawrence’s ideas about the non-human can be seen as a prototype for what we now recognise as ecological thinking.

O objetivo do artigo é apresentar uma possibilidade de análise do processo criativo no âmbito artístico sob o ponto de vista do acaso, tendo como ponto de partida as reflexões de Merleau-Ponty em seu texto intitulado A dúvida de Cézanne. Parto da ideia de que há, nesse texto, um interessante esboço da importância do papel do acaso, tanto na constituição de uma vida quanto na criação de uma obra de arte, levando em conta a íntima conexão entre ambas. Dois pensadores foram escolhidos como auxiliares nessa empreitada: Charles Sanders Peirce, no âmbito da filosofia, e Fayga Ostrower, no campo das artes. Não tenho como objetivo estabelecer paralelismos entre seus projetos, mas explorar, a partir de algumas ressonâncias, outra possibilidade de leitura sobre o sentido da obra e da vida do artista, em um acréscimo à análise merleau-pontiana.

Merleau-Ponty’s essay about Cézanne’s doubt from 1946 is still in discussion. Merleau-Ponty tries to explain the peculiarities of Cézanne’s pictorial language, for instance his abandonment of the geometrical perspective, as expression of, what he calls, the “primordial perception”, which is free from the distortions of metaphysical dualism and of modern sciences. There are two main problems here: 1. that primordiality remains an obscure notion, which is more explained by Cézannes work, than it explains it. 2. Merleau-Ponty tends to forget, that Cézanne’s perception is first of all a painters perception, inspired by the idea of what a painting should be and by a conception of the physical performances by which it comes into being. Cézanne tries to liberate painting from the Albertinian idea, that the work is similar to a window, opening the view on a section of reality. Contrary to this he stresses the autonomy of the work, its presence as being painted, without giving up its contact to the reality depicted.

Background: Endometrial cancer is generally one of the most evident malignant tumours of the female reproductive system, and the mechanisms underlying its cell proliferation and apoptosis are key to research in gynaecological oncology. In the paper, the in-depth molecular mechanism by which DJ-1 protein regulates the proliferation and apoptosis of Ishikawa cells was investigated. Methods and results: DJ-1 knockdown and overexpressing Ishikawa stable cell lines were established by lentiviral transduction. The levels of DJ-1 and noncanonical NF-κB signaling key proteins were evaluated by Western blotting. Cell counting kit-8 (CCK-8) and flow cytometry were applied to analyze the cell viability and apoptosis. Co-immunoprecipitation experiment was utilized to assess the DJ-1-Cezanne interaction. The results showed that DJ-1 overexpression conferred apoptosis resistance and high proliferation on Ishikawa cells, while DJ-1 knockdown in Ishikawa cells produced the opposite results. These findings again suggested that DJ-1 inhibits the apoptosis and promotes the proliferation of Ishikawa cells. More crucially, further data showed that the noncanonical NF-κB activation was required for the regulation of Ishikawa cell proliferation and apoptosis by DJ-1. Meanwhile, it was found that noncanonical NF-κB pathway may be activated by DJ-1 interacting with and negatively regulating Cezanne in Ishikawa cells. Conclusions: Overall, this work revealed that DJ-1 associates with and negatively regulates Cezanne and consequently triggers the noncanonical NF-κB activation, thereby regulating Ishikawa cell proliferation and apoptosis. [ABSTRACT FROM AUTHOR]

El objetivo de este artículo es abordar dónde queda la cuestión de la belleza en el panorama del arte abstracto contemporáneo, en qué términos podría determinarse y concretarse, cuál sería su naturaleza y los parámetros marco donde correspondería buscarla. Para ello se realiza un recorrido a lo largo de la historia de esta corriente artística, desde sus comienzos hasta llegar a nuestros días, tanto desde el punto de vista teórico, mediante los presupuestos que lo definen emitidos por los teóricos, críticos de arte y los propios artistas, así como también a la vista de las trayectorias de aquellos entre estos últimos que ejemplifican el origen y evolución del arte abstracto contemporáneo

Resumo O presente trabalho explora o expediente metodológico aplicado por Merleau-Ponty sobre a obra e a vida de Cézanne: a vida como exigência de uma obra. Discutimos como esse expediente oferece uma chave de leitura para as polêmicas relações entre a vida e a obra nietzschiana, tanto no sentido de verificar como Nietzsche se apresenta internamente à sua obra, quanto para analisar como as circunstâncias de sua vida (doença, solidão, amizade, nomadismo, geografia, clima e distrações corporais) podem ser interpretadas como exigências do tipo de obra que ele se propôs a formular. Isso nos leva a uma nova estratégia para interpretar também a própria genealogia da obra nietzschiana e, com ele, de toda a história da filosofia.

O propósito deste artigo é mostrar que a pintura do francês Paul Cézanne possibilitou a Merleau-Ponty uma maneira de ver o mundo em sua origem: um lugar ambíguo, reversível. Ao expressar a natureza na tela, o pintor realizava aquilo que o filósofo queria fazer na filosofia: a reconstituição do mundo como sentido de ser absolutamente diferente do “representado”, a saber, como ser vertical que nenhuma das “representações” esgota e que todas “atingem”, o “Ser selvagem”. É em Cézanne que Merleau-Ponty encontra a crença no mundo da percepção, mundo onde há uma reversibilidade do visível e do invisível, a partir da qual a pintura acontece. Este trabalho trata, pois, da investigação merleau-pontyana das teorias e obras de Cézanne: a concepção de representar os objetos em perspectiva e a busca por cores adequadas e pelo contorno que expressa a profundidade do mundo vivido. Com um olho em Cézanne e outro no mundo da vida, Merleau -Ponty elabora uma teoria onde mostra a origem do sentido e nos faz perceber o “mundo primordial”.

Since its discovery forty years ago, protein ubiquitination has been an ever-expanding field. Virtually all biological processes are controlled by the post-translational conjugation of ubiquitin onto target proteins. In addition, since ubiquitin controls substrate degradation through the action of hundreds of enzymes, many of which represent attractive therapeutic candidates, harnessing the ubiquitin system to reshape proteomes holds great promise for improving disease outcomes. Among the numerous physiological functions controlled by ubiquitin, the cell cycle is among the most critical. Indeed, the discovery that the key drivers of cell cycle progression are regulated by the ubiquitin-proteasome system (UPS) epitomizes the connection between ubiquitin signaling and proliferation. Since cancer is a disease of uncontrolled cell cycle progression and proliferation, targeting the UPS to stop cancer cells from cycling and proliferating holds enormous therapeutic potential. Ubiquitination is reversible, and ubiquitin is removed from substrates by catalytic proteases termed deubiquitinases or DUBs. While ubiquitination is tightly linked to proliferation and cancer, the role of DUBs represents a layer of complexity in this landscape that remains poorly captured. Due to their ability to remodel the proteome by altering protein degradation dynamics, DUBs play an important and underappreciated role in the cell cycle and proliferation of both normal and cancer cells. Moreover, due to their enzymatic protease activity and an open ubiquitin binding pocket, DUBs are likely to be important in the future of cancer treatment, since they are among the most druggable enzymes in the UPS. In this review we summarize new and important findings linking DUBs to cell cycle and proliferation, as well as to the etiology and treatment of cancer. We also highlight new advances in developing pharmacological approaches to attack DUBs for therapeutic benefit. [ABSTRACT FROM AUTHOR]

In many ways, Paul Cézanne was considered an anti-classical painter. However, through some of his works, we can notice the influence of Greek imagery, which was exerted on him when he was a young copyist at the Louvre. In the painting Bathers at Rest (Barnes Foundation, Philadelphia), the posture of the lying bather offers a prime example. This posture on the ground, knee erected, arm wound around the head, is well known in Greek art, and mainly used to show a fighter fatally struck during a battle. This stance seems affected and almost absurd for a dying man, intensifying the battle’s drama. But how to explain Hector adopting the same stance in the Priam embassy representations? What is the narrative intent behind this choice of body position outside of a battle scene? Evidence supports that this particular posture, some details of which are reminiscent of the Homeric literature, is a reflection of a school of thought deeply rooted in the Greek imagination.

Can concepts or artistic practices be transferred from one culture, one region, one land to another; and how much can another cultural context modify the meaning and function of a given artistic language, in the present case a language of painters? We can move nearer to an understanding of the problem if we bear in mind that cultural transfer differs essentially from comparison since it builds on the premise that there are no national cultures that have developed in an autochthonous way. These cultures have formed in the wake of influences, co-habitation, and motif adoption of many different kinds. Investigation of cultural transfers, then, emphasises similarities existing in social memory and not on differences. The art history of the time around 1900 has been recorded by way of the narrative of progressivism, in the paradigm of the centre and the periphery. The model itself is historical. We can and should remark upon on the material of past in its capacity as such and we may emphasise different aspects of it. Nevertheless, the material of the past is malleable only up to a certain limit. The historical marker of the art of the era under discussion is progressivism: we would be ahistorical were we to divest it of this tag. This paper presents the problems of cultural transfer on the example of Hungarian and French fauvism, involving the reception of renowned art historians and thinkers such as Adolf Hildebrand, Julius Meier-Graefe or Georg Lukacs.

Cysteine oxidation occurs at the active site of deubiquitinases (DUBs) during many biologic signaling cascades. Here we report that hepatocellular carcinoma cells (HCCs) generated higher levels of endogenous reactive oxygen species (ROS). This elevated ROS production was inhibited by NADPH oxidase inhibitor diphenylene iodonium (DPI) and mitochondria electron chain inhibitor rotenone in HCC cells. Moreover, we found that H2O2 could activate NF-kB-dependent inflammatory effect through increased induction of matrix metalloproteinase 2 (MMP2), MMP9, and intercellular adhesion molecule 1 (ICAM1) expression levels. In addition, we found that H2O2 could prolong NF-kB activation by suppressing the negative regulatory functions of Cezanne in HCC cells. Ubiquitin-derived thiol-reactive probe (HA-UbVME) assay and biotin-tagged 1,3- cyclohexadione derivative (DCP-Bio1) assay showed that H2O2 has the capacity to inhibit the catalytic activity of Cezanne, and the reducing agent, DTT, could reactivate the Cezanne deubiquitinating enzyme activity. Taken all together, these findings demonstrated an important role for oxidation of Cezanne by ROS in regulation of the inflammatory effect of hepatocellular carcinoma. [ABSTRACT FROM AUTHOR]

Cezanne is the father of modern art. His place in the history of art is solid and contemporary art is also oriented in the direction of the art he has transformed. This article is the first integrated paper to attempt to explain Cezanne from an unconscious point of view and a basic study informing the beginning of the paper to be carried forward. I briefly describe Cezanne’s life, the change of his style of art, important concepts that Cezanne thinks of such as nature, sensation, color and how he works. On the basis of this, I reveal how that the art form of Cezanne changed through his relationship with Pissarro was related to the function of the ego, and the incompatible task Cezanne sought to pursue ‘eternal life in a changing landscape’ and ‘expressing living life within a solid structure’ can be explained as a structural model of the unconscious. This study forms a significant basis for explaining my papers on Cezanne in the future. The study of Cezanne will hold a meaningful position in the art history from the unconscious perspective. [ABSTRACT FROM AUTHOR]

A turning point in Peter Handke's career following a deep crisis of writing, the text Die Lehre der Sainte‐Victoire () represents a fundamental transformation of the writer's poetological project and material practice of writing. The poetry of Friedrich Hölderlin, the paintings of Paul Cézanne, and the patchwork method of clothing designer Domenika Kaesdorf emerge as key influences within this transformation. Hölderlin's idealization of the poet's task and Cézanne's and Kaesdorf's physical methods, however, are no mere metaphors for Handke's process of writing; rather, Handke takes up and translates these modes into his material practice. This essay thus models a particular kind of reception history, one in which textual thematics are actualized in physical practice and semantic content is entangled in the material and visual dimensions of texts. Such an approach exemplifies the potential of incorporating materiality and meaning to expand the field of textual interpretation. [ABSTRACT FROM AUTHOR]

The Anaphase-Promoting Complex/Cyclosome (APC/C) is an E3 ubiquitin ligase and a key regulator of cell cycle progression. By triggering the degradation of mitotic cyclins, APC/C controls cell cycle-dependent oscillations in cyclin-dependent kinase (CDK) activity. Thus, the dynamic activities of both APC/C and CDK sit at the core of the cell cycle oscillator. The APC/C controls a large number of substrates and is regulated through multiple mechanisms, including cofactor-dependent activation. These cofactors, Cdc20 and Cdh1, recognize substrates, while the specific E2 enzymes UBE2C/UbcH10 and UBE2S cooperate with APC/C to build K11-linked ubiquitin chains on substrates to target them for proteasomal degradation. However, whether deubiquitinating enzymes (DUBs) can antagonize APC/C substrate ubiquitination during mitosis has remained largely unknown. We recently demonstrated that Cezanne/OTUD7B is a cell cycle-regulated DUB that opposes the ubiquitination of APC/C substrates. Cezanne binds APC/C substrates, reverses their ubiquitination and protects them from degradation. Accordingly, Cezanne depletion accelerates APC/C substrate degradation, leading to errors in mitotic progression and formation of micronuclei. Moreover, Cezanne is significantly amplified and overexpressed in breast cancers. This suggests a potential role for APC/C antagonism in the pathogenesis of disease. APC/C contributes to chromosome segregation fidelity in mitosis raising the possibility that copy-number and expression changes in Cezanne observed in cancer contribute to the etiology of disease. Collectively, these observations identify a new player in cell cycle progression, define mechanisms of tempered APC/C substrate destruction and highlight the importance of this regulation in maintaining chromosome stability. [ABSTRACT FROM AUTHOR]

Joan Vinyoli, aquest treball aprofundeix en l’interès que el poeta txec li va traslladar per la pintura de Cézanne i per la seua doctrina de la composició artística. L’aprofundiment d’aquesta relació interdiscursiva entre pintura i poesia s’exemplifica en la hipertextualitat que hi ha en dos poemes primerencs de Vinyoli, provinents dels seus dos primers poemaris, basats cadascun en dos quadres del pintor francès i elaborats des de la transformació seriosa o transposició en paraules. Paraules clau: Cézanne, Vinyoli, quadres, poemes.

Nas reflexões de Merleau-Ponty, presentes em seu texto sobre A dúvida de Cézanne, podemos ressaltar duas maneiras de abordar a criação pictórica: uma dando maior peso às determinações, às influências, à personalidade, às experiências de vida do pintor; e outra que se desenvolve a partir de uma reflexão sobre a liberdade que caracteriza o processo criativo. A primeira via atribui a peculiaridade da pintura de Cézanne à sua esquizoidia, ao seu temperamento difícil, ao seu isolamento. A segunda aponta esses elementos também como consequências e não apenas como causas do projeto do pintor, resguardando a liberdade do artista. Merleau-Ponty pretende mostrar que a vida e a obra do pintor estão emaranhadas, mas também que a obra não é pura consequência dos dados da vida, nem fruto de um total desprendimento com relação a eles. O filósofo pretende fugir de concepções tendenciosas que explicam a obra ou como uma necessidade imposta pelos dados da vida, ou como fruto de uma capacidade de transcendê-los totalmente. Vejamos como Merleau-Ponty lida com esse problema e qual é o caminho por ele proposto para pensar o sentido da obra.

This paper claims to reflect upon some critical essays in which Gianni Celati deals with the issues of vision, perception, and literary description of the space. Through the analysis of some texts where Celati refers to painting and sculpture (particularly Alberto Giacometti's works), it will emerge the author's thought about art and the characteristics of his non-fiction writing will be highlighted as well. [ABSTRACT FROM AUTHOR]

Starting with a review of Rilke's literary influence on the early poetic writings of JoanVinyoli, this paper goes on to delve more deeply into how the Czech poet shared with Vinyoli his interest in Cézanne's paintings and in the French artist's doctrine of artístic composition. The interdisciplinary relationship between painting and poetry can be deeply appreciated in the hypertextuality between two early poems by Vinyoli, one from each of his first two books, both poems based on paintings by the French artist and both featuring greatly transformed or transposed words. [ABSTRACT FROM AUTHOR]

This well-organized collection invites us to engage Poteat's post-critical understanding of personhood. The essays on philosophical anthropology call us to responsible personhood as they focus on various topics, including Poteat's teaching, the meaning of post-critical and how and when we should think critically, and the importance of place. The three essays engaging theology share a theme of our grounding through our embodiment in a relational, incarnational world. The final two essays, the last by Poteat, focus on Cézanne's paintings as a thick material and mental enactive mindbodily process, in which the paintings "think themselves" in Cézanne and in the viewer. [ABSTRACT FROM AUTHOR]

The overall aim of this paper is to defend the value of the arts as uniquely instructive regarding philosophical questions. Specifically, I aim to achieve two things: firstly, to show that through the phenomenological challenge to dualist and monist ontologies the key debate in aesthetics regarding subjective response and objective judgment is reconfigured and resolved. I argue that Merleau-Ponty's analyses complement and complete Kant's project. Secondly, I propose that through Merleau-Ponty's phenomenological interrogations of the creative process the broader issue of the viability of his relational nondualist ontology is defended against accusations that it has not gone beyond dualism or that it has collapsed into a monism. [ABSTRACT FROM AUTHOR]

Immune system activation is essential to thwart the invasion of pathogens and respond appropriately to tissue damage. However, uncontrolled inflammation can result in extensive collateral damage underlying a diverse range of auto-inflammatory, hyper-inflammatory, and neoplastic diseases. The NF-kB signaling pathway lies at the heart of the immune system and functions as a master regulator of gene transcription. Thus, this signaling cascade is heavily targeted by mechanisms designed to attenuate overzealous inflammation and promote resolution. Mechanisms associated with the negative regulation of NF-kB signaling are currently under intense investigation and have yet to be fully elucidated. Here, we provide an overview of mechanisms that negatively regulate NF-kB signaling through either attenuation of signal transduction, inhibition of posttranscriptional signaling, or interference with posttranslational modifications of key pathway components. While the regulators discussed for each group are far from comprehensive, they exemplify common mechanistic approaches that inhibit this critical biochemical signaling cascade. Despite their diversity, a commonality among these regulators is their selection of specific targets at key inflection points in the pathway, such as TNF-receptor-associated factor family members or essential kinases. A better understanding of these negative regulatory mechanisms will be essential to gain greater insight related to the maintenance of immune system homeostasis and inflammation resolution. These processes are vital elements of disease pathology and have important implications for targeted therapeutic strategies. [ABSTRACT FROM AUTHOR]

Este artigo pretende demonstrar que aquilo que é conhecido como percepção delirante na esquizofrenia é uma experiência que os artistas geniais experimentaram e expressaram em seu trabalho. A conclusão do autor é a de que tanto a esquizofrenia quanto a genialidade artística são estados espirituais nos quais a essência de algo é percebida em sua forma mais paradigmática.