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Current paper characterizes deaths by accidents with motorcycles and analyzes mortality trends by time series retrieved from data on deaths of motorcycles drivers in traffic accidents in the state of Goiás, Brazil, between 2000 and 2015, provided by the Mortality Information System. Social and demographic variables, data on number of motorcycles and yearly annual death rates were analyzed by descriptive and inferential statistics. There was a 152.27% increase in mortality rates of motorcycles drivers per 100,000 inhabitants during the period, with 3.09 going to 8.30 deaths per 100,000 inhabitants; in the case of females, increase reached 268.84%. However, young men die more frequently in motorcycle accidents in Goiás, with 88.09% of deaths (n=5.417). Further, death rate increased between 2000 and 2015 and death rates increased per motorcycle accident, characterizing the event as an issue of public health which fails in effective measures to reduce harm to the community. [ABSTRACT FROM AUTHOR]