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1. Sources of variation of DNA methylation in rainbow trout: combined effects of temperature and genetic background

Author

Delphine Lallias, Maria Bernard, Céline Ciobotaru, Nicolas Dechamp, Laurent Labbé, Lionel Goardon, Jean-Michel Le Calvez, Marjorie Bideau, Alexandre Fricot, Audrey Prézelin, Mathieu Charles, Marco Moroldo, Xavier Cousin, Olivier Bouchez, Alain Roulet, Edwige Quillet, and Mathilde Dupont-Nivet

Subjects
temperature, epiradseq, dna methylation, dnmt3, rainbow trout, isogenic lines, Genetics, QH426-470
Abstract

Phenotypic plasticity is a key component of the ability of organisms to respond to changing environmental conditions. In this study, we aimed to study the establishment of DNA methylation marks in response to an environmental stress in rainbow trout and to assess whether these marks depend on the genetic background. The environmental stress chosen here was temperature, a known induction factor of epigenetic marks in fish. To disentangle the role of epigenetic mechanisms such as DNA methylation in generating phenotypic variations, nine rainbow trout isogenic lines with no genetic variability within a line were used. For each line, half of the eggs were incubated at standard temperature (11°C) and the other half at high temperature (16°C), from eyed-stage to hatching. In order to gain a first insight into the establishment of DNA methylation marks in response to an early temperature regime (control 11°C vs. heated 16°C), we have studied the expression of 8 dnmt3 (DNA methyltransferase) genes, potentially involved in de novo methylation, and analysed global DNA methylation in the different rainbow trout isogenic lines using LUMA (LUminometric Methylation Assay). Finally, finer investigation of genome-wide methylation patterns was performed using EpiRADseq, a reduced-representation library approach based on the ddRADseq (Double Digest Restriction Associated DNA) protocol, for six rainbow trout isogenic lines. We have demonstrated that thermal history during embryonic development alters patterns of DNA methylation, but to a greater or lesser extent depending on the genetic background.

Published
2021
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2. Genetic determinism of spontaneous masculinisation in XX female rainbow trout: new insights using medium throughput genotyping and whole-genome sequencing

Author

Clémence Fraslin, Florence Phocas, Anastasia Bestin, Mathieu Charles, Maria Bernard, Francine Krieg, Nicolas Dechamp, Céline Ciobotaru, Chris Hozé, Florent Petitprez, Marine Milhes, Jérôme Lluch, Olivier Bouchez, Charles Poncet, Philippe Hocdé, Pierrick Haffray, Yann Guiguen, and Edwige Quillet

Subjects
Medicine, Science
Abstract

Abstract Rainbow trout has a male heterogametic (XY) sex determination system controlled by a major sex-determining gene, sdY. Unexpectedly, a few phenotypically masculinised fish are regularly observed in all-female farmed trout stocks. To better understand the genetic determinism underlying spontaneous maleness in XX-rainbow trout, we recorded the phenotypic sex of 20,210 XX-rainbow trout from a French farm population at 10 and 15 months post-hatching. The overall masculinisation rate was 1.45%. We performed two genome-wide association studies (GWAS) on a subsample of 1139 individuals classified as females, intersex or males using either medium-throughput genotyping (31,811 SNPs) or whole-genome sequencing (WGS, 8.7 million SNPs). The genomic heritability of maleness ranged between 0.48 and 0.62 depending on the method and the number of SNPs used for the estimation. At the 31K SNPs level, we detected four QTL on three chromosomes (Omy1, Omy12 and Omy20). Using WGS information, we narrowed down the positions of the two QTL detected on Omy1 to 96 kb and 347 kb respectively, with the second QTL explaining up to 14% of the total genetic variance of maleness. Within this QTL, we detected three putative candidate genes, fgfa8, cyp17a1 and an uncharacterised protein (LOC110527930), which might be involved in spontaneous maleness of XX-female rainbow trout.

Published
2020
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3. Genetic and transcriptomic analyses provide new insights on the early antiviral response to VHSV in resistant and susceptible rainbow trout

Author

Eloi R. Verrier, Carine Genet, Denis Laloë, Florence Jaffrezic, Andrea Rau, Diane Esquerre, Nicolas Dechamp, Céline Ciobotaru, Caroline Hervet, Francine Krieg, Luc Jouneau, Christophe Klopp, Edwige Quillet, and Pierre Boudinot

Subjects
Rainbow trout, VHSV, Antiviral resistance, Transcriptome deep sequencing, QTL, Biotechnology, TP248.13-248.65, Genetics, QH426-470
Abstract

Abstract Background The viral hemorrhagic septicemia virus (VHSV) is a major threat for salmonid farming and for wild fish populations worldwide. Previous studies have highlighted the importance of innate factors regulated by a major quantitative trait locus (QTL) for the natural resistance to waterborne VHSV infection in rainbow trout. The aim of this study was to analyze the early transcriptomic response to VHSV inoculation in cell lines derived from previously described resistant and susceptible homozygous isogenic lines of rainbow trout to obtain insights into the molecular mechanisms responsible for the resistance to the viral infection. Results We first confirmed the presence of the major QTL in a backcross involving a highly resistant fish isogenic line (B57) and a highly susceptible one (A22), and were able to define the confidence interval of the QTL and to identify its precise position. We extended the definition of the QTL since it controls not only resistance to waterborne infection but also the kinetics of mortality after intra-peritoneal injection. Deep sequencing of the transcriptome of B57 and A22 derived cell lines exposed to inactivated VHSV showed a stronger response to virus inoculation in the resistant background. In line with our previous observations, an early and strong induction of interferon and interferon-stimulated genes was correlated with the resistance to VHSV, highlighting the major role of innate immune factors in natural trout resistance to the virus. Interestingly, major factors of the antiviral innate immunity were much more expressed in naive B57 cells compared to naive A22 cells, which likely contributes to the ability of B57 to mount a fast antiviral response after viral infection. These observations were further extended by the identification of several innate immune-related genes localized close to the QTL area on the rainbow trout genome. Conclusions Taken together, our results improve our knowledge in virus-host interactions in vertebrates and provide novel insights in the molecular mechanisms explaining the resistance to VHSV in rainbow trout. Our data also provide a collection of potential markers for resistance and susceptibility of rainbow trout to VHSV infection.

Published
2018
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4. Resistance to a rhabdovirus (VHSV) in rainbow trout: identification of a major QTL related to innate mechanisms.

Author

Eloi R Verrier, Michel Dorson, Stéphane Mauger, Corinne Torhy, Céline Ciobotaru, Caroline Hervet, Nicolas Dechamp, Carine Genet, Pierre Boudinot, and Edwige Quillet

Subjects
Medicine, Science
Abstract

Health control is a major issue in animal breeding and a better knowledge of the genetic bases of resistance to diseases is needed in farm animals including fish. The detection of quantitative trait loci (QTL) will help uncovering the genetic architecture of important traits and understanding the mechanisms involved in resistance to pathogens. We report here the detection of QTL for resistance to Viral Haemorrhagic Septicaemia Virus (VHSV), a major threat for European aquaculture industry. Two induced mitogynogenetic doubled haploid F2 rainbow trout (Oncorhynchus mykiss) families were used. These families combined the genome of susceptible and resistant F0 breeders and contained only fully homozygous individuals. For phenotyping, fish survival after an immersion challenge with the virus was recorded, as well as in vitro virus replication on fin explants. A bidirectional selective genotyping strategy identified seven QTL associated to survival. One of those QTL was significant at the genome-wide level and largely explained both survival and viral replication in fin explants in the different families of the design (up to 65% and 49% of phenotypic variance explained respectively). These results evidence the key role of innate defence in resistance to the virus and pave the way for the identification of the gene(s) responsible for resistance. The identification of a major QTL also opens appealing perspectives for selective breeding of fish with improved resistance.

Published
2013
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5. Genetic determinism of spontaneous masculinisation in XX female rainbow trout: new insights using medium throughput genotyping and whole-genome sequencing

Author

Charles Poncet, Florent Petitprez, Maria Bernard, Edwige Quillet, Chris Hoze, Nicolas Dechamp, Philippe Hocdé, Anastasia Bestin, Céline Ciobotaru, Yann Guiguen, Pierrick Haffray, Marine Milhes, Florence Phocas, Olivier Bouchez, Jérôme Lluch, Clémence Fraslin, Mathieu Charles, Francine Krieg, Génétique Animale et Biologie Intégrative (GABI), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of Edinburgh, Syndicat des Sélectionneurs Avicoles et Aquacoles Français (SYSAAF), Système d'Information des GENomes des Animaux d'Elevage (SIGENAE), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Allice, Ligue Nationale Contre le Cancer - Paris, Ligue Nationale Contre le Cancer (LNCC), Génome et Transcriptome - Plateforme Génomique ( GeT-PlaGe), Plateforme Génome & Transcriptome (GET), Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Génétique Diversité et Ecophysiologie des Céréales (GDEC), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Pisciculture Charles Murgat, Laboratoire de Physiologie et Génomique des Poissons (LPGP), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), European Maritime and Fisheries Fund and France Agrimer co-funded this work (NeoBio project, n° RFEA470016FA1000008), Ligue Nationnale Contre le Cancer, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Paris-Saclay-AgroParisTech-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse)

Subjects
0106 biological sciences, 0301 basic medicine, Male, Candidate gene, QTL, animal diseases, [SDV]Life Sciences [q-bio], Masculinisation des poissons, Genome-wide association study, heritability, 01 natural sciences, Genome-wide association studies, Genetics, 0303 health sciences, education.field_of_study, Multidisciplinary, biology, Reproduction, 04 agricultural and veterinary sciences, Genomics, Poisson, Trout, Phenotype, Oncorhynchus mykiss, maleness, Medicine, Female, Sex, Maleness, Heterogametic sex, endocrine system, animal structures, Genotype, Science, Population, Quantitative trait locus, Déterminisme génétique du sexe, 010603 evolutionary biology, Article, Heritability, 03 medical and health sciences, Salmonide, Genetic variation, sex, Animals, 14. Life underwater, education, 030304 developmental biology, Genetic association, Animal breeding, fish, Whole Genome Sequencing, urogenital system, Truite arc-en-ciel, 0402 animal and dairy science, Sex Determination Processes, biology.organism_classification, 040201 dairy & animal science, 030104 developmental biology, Fish, Rainbow trout, Sequençage
Abstract

Rainbow trout has a male heterogametic (XY) sex determination system controlled by a major sex-determining gene, sdY. Unexpectedly, a few phenotypically masculinised fish are regularly observed in all-female farmed trout stocks. To better understand the genetic determinism underlying spontaneous maleness in XX-rainbow trout, we recorded the phenotypic sex of 20,210 XX-rainbow trout from a French farm population at 10 and 15 months post-hatching. The overall masculinisation rate was 1.45%. We performed two genome-wide association studies (GWAS) on a subsample of 1139 individuals classified as females, intersex or males using either medium-throughput genotyping (31,811 SNPs) or whole-genome sequencing (WGS, 8.7 million SNPs). The genomic heritability of maleness ranged between 0.48 and 0.62 depending on the method and the number of SNPs used for the estimation. At the 31K SNPs level, we detected four QTL on three chromosomes (Omy1, Omy12 and Omy20). Using WGS information, we narrowed down the positions of the two QTL detected on Omy1 to 96 kb and 347 kb respectively, with the second QTL explaining up to 14% of the total genetic variance of maleness. Within this QTL, we detected three putative candidate genes, fgfa8, cyp17a1 and an uncharacterised protein (LOC110527930), which might be involved in spontaneous maleness of XX-female rainbow trout.

Published
2020
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6. Analysis of genomewide patterns of DNA methylation in response to an early temperature stress in rainbow trout

Author

Delphine Lallias, Edwige Quillet, Maria Bernard, Céline Ciobotaru, Nicolas Dechamp, Jean-Michel Le Calvez, Marjorie Bideau, Lionel Goardon, Laurent Labbé, Mathilde Dupont-Nivet, Génétique Animale et Biologie Intégrative (GABI), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Pisciculture Expérimentale INRA des Monts d'Arrée (PEIMA), and Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2019

7. Rna-seq analysis of transcriptome response to VHS-V infection in two target tissues of resistant vs susceptible trout clonal lines

Author

Carine Genet, Verrier, E. R., Céline Ciobotaru, Christophe Klopp, Diane Esquerre, Denis Laloë, Pierre Boudinot, Edwige Quillet, Génétique Animale et Biologie Intégrative (GABI), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, UMR1110, Institut National de la Santé et de la Recherche Médicale (INSERM), Unité de Biométrie et Intelligence Artificielle (UBIA), Institut National de la Recherche Agronomique (INRA), Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-École nationale supérieure agronomique de Toulouse [ENSAT], Unité de recherche Virologie et Immunologie Moléculaires (VIM), École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, and Unité de recherche Virologie et Immunologie Moléculaires (VIM (UR 0892))

Subjects
resistance, [SDV]Life Sciences [q-bio], identification, virus, gene, vhs-v, transcriptome, infection
Abstract

absent

Published
2014

8. Identification de gènes différentiellement exprimés dans deux tissus cibles de lignées clonales de truite sensibles ou résistantes à la SHV

Author

Carine Genet, Verrier, E. R., Céline Ciobotaru, Christophe Klopp, Diane Esquerre, Denis Laloë, Pierre Boudinot, Edwige Quillet, Génétique Animale et Biologie Intégrative (GABI), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, UMR1110, Institut National de la Santé et de la Recherche Médicale (INSERM), Unité de Biométrie et Intelligence Artificielle (ancêtre de MIAT) (UBIA), Institut National de la Recherche Agronomique (INRA), Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-École nationale supérieure agronomique de Toulouse [ENSAT], Unité de recherche Virologie et Immunologie Moléculaires (VIM (UR 0892)), ProdInra, Archive Ouverte, Unité de Biométrie et Intelligence Artificielle (UBIA), École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Unité de recherche Virologie et Immunologie Moléculaires (VIM), and AgroParisTech-Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio]
Abstract

absent

Published
2014

9. Resistance to a Rhabdovirus (VHSV) in Rainbow Trout: Identification of a Major QTL Related to Innate Mechanisms

Author

M. Dorson, Nicolas Dechamp, Corinne Torhy, Pierre Boudinot, Stéphane Mauger, Caroline Hervet, Carine Genet, Céline Ciobotaru, Edwige Quillet, Eloi R. Verrier, Génétique Animale et Biologie Intégrative (GABI), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Unité de recherche Virologie et Immunologie Moléculaires (VIM), Institut National de la Recherche Agronomique (INRA), European Community (IFOP), French Ministry of Research [2004/190], European Community's SeventhFramework Programme (FP7), Research Infrastructures action [FP7-228394], Animal Genetics and Animal Health Divisions of INRA, Unité de recherche Virologie et Immunologie Moléculaires (VIM (UR 0892)), and Quillet, Edwige

Subjects
Male, Aquaculture, Virus Replication, Tissue Culture Techniques, Hemorrhagic Septicemia, Viral, Animal Breeding, Animal Management, Genetics, 0303 health sciences, Novirhabdovirus, trout, Genome, Multidisciplinary, biology, qtl, Homozygote, Chromosome Mapping, Agriculture, 04 agricultural and veterinary sciences, Sciences du Vivant [q-bio]/Microbiologie et Parasitologie, Survival Rate, Trout, Phenotype, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Veterinary Diseases, Oncorhynchus mykiss, fish, Medicine, Female, Fish Farming, rhabdovirus, Ichthyology, Research Article, Genotype, Science, Quantitative Trait Loci, Quantitative trait locus, Selective breeding, 03 medical and health sciences, Animals, 14. Life underwater, Biology, Gene, 030304 developmental biology, Veterinary Virology, biology.organism_classification, Immunity, Innate, Genetic architecture, Genetics of Disease, 040102 fisheries, Doubled haploidy, 0401 agriculture, forestry, and fisheries, Veterinary Science, Rainbow trout, Animal Genetics, Zoology, truite arc en ciel
Abstract

Chantier qualité GA; Health control is a major issue in animal breeding and a better knowledge of the genetic bases of resistance to diseases is needed in farm animals including fish. The detection of quantitative trait loci (QTL) will help uncovering the genetic architecture of important traits and understanding the mechanisms involved in resistance to pathogens. We report here the detection of QTL for resistance to Viral Haemorrhagic Septicaemia Virus (VHSV), a major threat for European aquaculture industry. Two induced mitogynogenetic doubled haploid F2 rainbow trout (Oncorhynchus mykiss) families were used. These families combined the genome of susceptible and resistant F0 breeders and contained only fully homozygous individuals. For phenotyping, fish survival after an immersion challenge with the virus was recorded, as well as in vitro virus replication on fin explants. A bidirectional selective genotyping strategy identified seven QTL associated to survival. One of those QTL was significant at the genome-wide level and largely explained both survival and viral replication in fin explants in the different families of the design (up to 65% and 49% of phenotypic variance explained respectively). These results evidence the key role of innate defence in resistance to the virus and pave the way for the identification of the gene(s) responsible for resistance. The identification of a major QTL also opens appealing perspectives for selective breeding of fish with improved resistance.

Published
2013
Full Text
View/download PDF

10. Gynogenetic clonal lines of rainbow trout O. mykiss, a model for the identification of new antiviral pathways

Author

Eloi Verrier, Michel Dorson, Nicolas Dechamp, Corinne Torhy, Sandrine Le Guillou, Céline Ciobotaru, Carine Genet, Pierre Boudinot, Edwige Quillet, Génétique Animale et Biologie Intégrative (GABI), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, 0892 Unité de Virologie et Immunologie Moléculaires, Institut National de la Recherche Agronomique (INRA), Unité de recherche Virologie et Immunologie Moléculaires (VIM), Virologie et Immunologie Moléculaires (VIM (UR 0892)), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité de recherche Virologie et Immunologie Moléculaires (VIM (UR 0892)), AgroParisTech-Institut National de la Recherche Agronomique (INRA), and Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
[SDV]Life Sciences [q-bio]
Abstract

absent

Published
2012

11. Gynogenetic clonal lines of rainbow trout[i] O. mykiss[/i], a model for the identification of new antiviral pathways

Author

Eloi Verrier, Michel Dorson, Christelle Langevin, Nicolas Dechamp, Corinne Torhy, Stéphane Mauger, Sandrine Le Guillou, Céline Ciobotaru, Carine Genet, Pierre Boudinot, Edwige Quillet, Génétique Animale et Biologie Intégrative (GABI), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Unité de recherche Virologie et Immunologie Moléculaires (VIM (UR 0892)), Institut National de la Recherche Agronomique (INRA), AgroParisTech-Institut National de la Recherche Agronomique (INRA), and Unité de recherche Virologie et Immunologie Moléculaires (VIM)

Subjects
[SDV.SA]Life Sciences [q-bio]/Agricultural sciences
Abstract

absent

12. Uncovering the genetic architecture of response to VHSV in rainbow trout O. mykiss

Author

Eloi Verrier, Michel Dorson, Nicolas Dechamp, Sandrine Le Guillou, Carine Genet, Céline Ciobotaru, Corinne Torhy, Pierre Boudinot, Edwige Quillet, Génétique Animale et Biologie Intégrative (GABI), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Unité de recherche Virologie et Immunologie Moléculaires (VIM (UR 0892)), Institut National de la Recherche Agronomique (INRA), and Unité de recherche Virologie et Immunologie Moléculaires (VIM)

Subjects
[SDV]Life Sciences [q-bio]
Abstract

absent

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