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1. Botulinum toxin type A for the treatment of excessive gingival display – A systematic review

Author

Simon Rasteau, Charles Savoldelli, Cécile Winter, Barbara Lerhe, Laurent Castillo, and Philippe Kestemont

Subjects
Otorhinolaryngology, Gingiva, Humans, Facial Muscles, Surgery, Botulinum Toxins, Type A, Esthetics, Dental, Oral Surgery, Smiling
Abstract

Gummy smile has traditionally been treated with invasive or demanding surgical and orthodontic techniques. Several studies have shown that targeted injection of the upper lip elevator muscles with botulinum toxin is an effective treatment for this condition. However, no standardized injection protocol with reproducible results has yet been published. A systematic review of the literature has been performed using Medline, Scopus, and Embase. All articles relevant to the research question were analyzed. After removing duplicates, 162 articles were selected, of which 9 were included in the analysis after applying exclusion and inclusion criteria, for a total of 269 patients. Onabotulinum toxin type A (ONA-BoNTA) was used in 7 studies and abobotulinum toxin type A (ABO- BoNTA) in 2 studies, at various dilutions. The number of sites injected varied from 1 to 3 per side, with variable targeting of the Levator labii superioris alaeque nasalis, Levator labii superioris, Zygomaticus minor, Zygomaticus major and Orbicularis oris. The dose used per side varied from 1.25 to 6 U of ONA-BoNTA and from 2.5 to 7.5 U of ABO- BoNTA. The injection protocol was tailored to the type of gingival smile in one study only, another study compared results of targeting two different muscles, and one study evaluated different dosages of toxin for the same injection site. The average improvement ranged from 24.85% to 99.65% and the effect persisted from 12 to 36 weeks. Very good patient satisfaction was reported in 6 studies. Fourteen adverse events were reported, all of them mild and transient. The treatment of gummy smile by botulinum toxin injection is effective, safe, rapid, minimally invasive and reversible. Protocols vary widely in the literature and no standardized procedure emerges. A patient-specific approach, adapted to their anatomy, type of gummy smile and the severity of the exposure seems to be the most appropriate. Randomized controlled studies are needed to make this approach more systematic.

Published
2022

2. Liquid Spreader Grafts: Internal Nasal Valve Opening with Hyaluronic Acid

Author

Thomas Radulesco, Cécile Winter, Philippe Kestemont, Frédéric Braccini, Laurent Castillo, and Justin Michel

Subjects
Surgery
Abstract

Nasal valve disorders frequently give rise to nasal obstruction. Dermal fillers could be used in the internal valve area to generate valve widening. The goal of this study was to report our "liquid spreader" procedure consisting in the injection of hyaluronic acid (HA) at the internal nasal valve in patients complaining of nasal obstruction.The procedure described in this paper is suitable for patients with unilateral or bilateral nasal obstruction related to architectural features resulting in narrowing of the internal nasal valve. HA is injected along the internal valve from a single entry point located at the anterior part of the internal valve, thus creating a volume which will induce nasal valve widening. Rhinomanometries and visual analog scales (VAS) regarding nasal obstruction were collected before and after the procedure.Sixteen patients were enrolled (7 females). Mean age was 44 years (min=24 y-o, max=65 y-o). Thirteen presented nasal valve narrowing without septal deviation while 3 patients had high septal deviation. Before injection, mean nasal resistances were 3.4±5.6 sPa/mL (min=0.55, max=19.8). One month after injection, mean nasal resistances were 0.38±0.26 sPa/mL (min = 0.20, max = 0.85). The difference was statistically significant (p=0.049). VAS scores were improved with a trend back to baseline after 12 months.The liquid spreader is a useful procedure that can be combined with non-surgical esthetic rhinoplasties. Level of Evidence IV This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Published
2022

3. A Safe Nonsurgical Rhinoplasty Procedure

Author

Thomas Radulesco, Frédéric Braccini, Philippe Kestemont, Cécile Winter, Laurent Castillo, and Justin Michel

Subjects
Cannula, Humans, Surgery, Hyaluronic Acid, Nose, Rhinoplasty, Injections
Abstract

Nonsurgical rhinoplasty procedures are not without risks: although rare, intravascular injections of hyaluronic acid can lead to serious complications. Very few authors have reported using cannulas for filler injection in the nose. The purpose of this article is to describe how the authors perform nonsurgical rhinoplasty using a single entry point and cannulas, significantly reducing vascular and infection risks. The procedure described in this article can be applied to all indications of nonsurgical rhinoplasty. The key point of the authors' procedure is the definition of a single, medial entry point. Using a 5-cm, 25-gauge, dome-shaped cannula, all nasal regions can be reached, from the anterior nasal spine to the nasion. The authors' nonsurgical rhinoplasty procedure using cannulas reduces complications and provides results similar to those achieved with needles.

Published
2022

4. Is Intrapartum Intravenous Zidovudine for Prevention of Mother-to-Child HIV-1 Transmission Still Useful in the Combination Antiretroviral Therapy Era?

Author

Nelly Briand, Josiane Warszawski, Laurent Mandelbrot, Catherine Dollfus, Emmanuelle Pannier, Ludovic Cravello, Rose Nguyen, Isabelle Matheron, Norbert Winer, Roland Tubiana, Christine Rouzioux, Albert Faye, Stéphane Blanche, Françoise Meier, Dominique Duro, Marine Joras, Emmanuel Mortier, Catherine Crenn-Hebert, Corinne Floch-Tudal, Fabienne Mazy, Mariam Bensalah, Agnès Villemant-Uludag, Agnès Lefort, Virginie Zarrouk, Pierre-François Ceccaldi, Gisèle Philip, Gilles Hittinger, Martine Malet, Bruno Bachelard, Marie Medus, Joëlle Dendale-Nguyen, Jean-Pierre Brossier, Olivier Aubry, Jean-Luc Esnault, Sophie Leautez, Philippe Perré, Isabelle Suaud, Sandrine-Anne Martha, Mahfoud Rouha, Pascale Perfezou, Gilles Blondin, Charles Bellot, Séverine Ansart, Philippe Le Moine, Karine Bages-Jaffuel, Jean-Charles Duthé, Michel Garré, Sylvain Jaffuel, Corinne Daniel, Christian Calvez, Claude Beuscart, Emmanuelle Boutaric, Jennifer Rohan, Sylvie Lemoal, Linda Lassel, Ghislaine Cotten, Christelle Dupré, Esther Beauville, Cédric Arvieux, Anabèle Dos Santos, Corinne Cudeville, Yves Poinsignon, Virginie Mouton-Rioux, Gaétane Mousset, Anne Grellier, Philippe Moreau, Philippe Tillaut, Odile Luycx-Vaillant, Philippe de Morel, Marie-Françoise Le Coz, Isabelle Belzic, Mathilde Niault, Anne Vandenbergh, Cécile Janssen, Susanne Braig, Virginie Vitrat, Jacques Gaillat, Gaëlle Clavere, Jean-Pierre Bru, Blandine Peyret, Catherine Mullard, Marie Echard, Philippe Talon, Marion Dehlinger, Cécile Winter, Brigitte Heller-Roussin, Odile Launay, Maria Fouchet, Ghislaine Firtion, Isabelle Goupil, Nora Boudjoudi, Agnès Bourgeois-Moine, Marylène Bodard, Valérie Vivier, Mandovi Rajguru, Virginie Huri, Elie Azria, Sophie Matheron, Neila Elaoun, Philippe Faucher, Valérie Garrait, Christiane Komme, Isabelle Hau, Laurent Richier, Claudine Touboul, Valérie Thoirain, Laurent Cotte, Olivier Tariel, Joseph Koffi, Jean-Marc Labaune, Corinne Brochier, Denis Roux, Christophe Elleau, Camille Runel, Henri Bataille, Marie-Thérèse Sow, Ketty Samar, Blandine Muanza, Marc Duval, Clarisse Kingue-Ekollo, Bénédicte Carpentier, Isabelle Ronda, Jean-Marc Chamouilli, Natacha Entz-Werle, Hervé Seaume, Sarah Ducrocq, Philippe Bailly-Salin, Yvon Lemercier, Joëlle Tricoire, Alain Berrebi, Michèle Antras, Evelyne Armand, Claudine Cayla, François Bonnal, Catherine Chabanier, Anne Chacé, Sophie Couderc, Anne Boutemy, Marie-Christelle Dallot, Alain Al-Issa, Corinne Routier, Ahmed Zakaria, Véronique Favret, Juliette Gerbe, Elisabeth Questiaux, MariaLuisa Partisani, David Rey, Christine Cheneau, Christine Allisy, Dominique Brault, François Hervé, Marie-Gisèle Lebrette, Lise Selleret, Dieudonné Ekoukou, Pascal Bolot, Marie-Aude Khuong-Josses, Marie-Christine Allemon, Nelly Ghibaudo, Pierre Frange, Florence Veber, Delphine Lemercier, Marie-Christine Mourey, Gilles Blasquez, Michèle Granier, Houda Touahri, Alain Devidas, Israël Nisand, Michèle Weil, Christophe Vayssière, Jean-Luc Berger, Martine Munzer, Olivier Graesslin, Anne-Florence Naime-Alix, Frédérique Quetin, Anne Laubies, Manuela Bonmarchand, Jennifer Sommer, Patricia Bourse, Anne Coursol, Michel Youssef, Juliette Laurent, Mariem Raho, Véronique Chambrin, Philippe Labrune, Laure Clech, Alexandra Benachi, Bertrand Le Lorier, Isolde Pauly-Ravelly, Claude Allouche, Ama Johnson, Laurence Benoist, Catherine Delannoy, Eric Lachassine, Stéphanie Bolie, Joël Gaudelus, Vincent Jeantils, Amelie Benabara, Leïla Karaoui, Véronique Lefèvre, André Bongain, Eliane Galiba, Anne Deville, Fabrice Monpoux, Jacques Durant, Christian Aufrant, Jean Furioli, Jean-Louis Salomon, Françoise Granier, Antoine Doumet, Youssef Douadi, Jean Gondry, Jean-Luc Schmit, Brigitte Pautard, Marc Gamerre, Isabelle Thuret, Laurence Neimann, Claire Hubert, Bruno Carbonne, Geneviève Vaudre, Marie-Dominique Tabone, Didier Pinquier, Gaëlle Pinto Cardoso, Brigitte Clavier, Françoise Borsa-Lebas, Agathe De Lauzanne, Constance Borie, Sandrine Leveillé, Erianna Bellaton, Dominique Garion, Martine Levine, Claire Colmant, Cécile Goujard, Marc Tardieu, Florent Fuchs, Ikram Jrad, Delphine Peretti, Katia Bourdic, Corinne Fourcade, Catherine Chirouze, Jean-Marie Estavoyer, Robert Maillet, Véronique Reliquet, Cécile Brunet, Isabelle Reynaud, Claire Briandet, Jacques Brouard, Gaël Beucher, Pascale Goubin, Cécile Lanty, Eric Froguel, Béatrice Gourdel, Arnaud Chalvon Demersay, Gilbert Algava, Véronique Hentgen, Fabienne Messaoudi, Pascale Nau, Jean-Marc Besnier, Jérôme Potin, Nadine Taché, Yves Bertrand, Kamila Kebaïli, Véronique Ronat, Anne Fresard, Kareen Billiemaz, Ramona Abrudan, Alain Fournié, Jean-Marie Chennebault, Philippe Arsac, Nicole Ciraru-Vigneron, Geneviève Mouchnino, Dominique Ayral, Nelly Guigue, Muriel Lalande, Paul Benos, Christiane De Gennes, Sonia Chanzy, Valérie Isart, François Cazassus, Véronique Walter, François Bissuel, Yamina Hammou, Sophie d'Angelo, Faïza Ajana, Françoise Mazingue, Raymond Mezin, Yves Hatchuel, André Cabié, and Narcisse Elenga

Subjects
Adult, Male, Microbiology (medical), medicine.medical_specialty, Anti-HIV Agents, HIV Infections, Zidovudine, Pregnancy, Risk Factors, immune system diseases, medicine, Humans, Prospective Studies, Pregnancy Complications, Infectious, Antibiotic prophylaxis, Prospective cohort study, Chi-Square Distribution, Obstetrics, Transmission (medicine), Vaginal delivery, business.industry, Infant, Newborn, virus diseases, Antibiotic Prophylaxis, Viral Load, medicine.disease, Infectious Disease Transmission, Vertical, Surgery, Infectious Diseases, Cohort, Female, business, Viral load, medicine.drug
Abstract

BACKGROUND: Intrapartum intravenous zidovudine (ZDV) prophylaxis is a long-standing component of prevention of mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) in high-resource countries. In some recent guidelines, intravenous ZDV is no longer systematically recommended for mothers receiving combination antiretroviral therapy (cART) with low viral load. We evaluated the impact of intravenous ZDV according to viral load and obstetrical conditions. METHODS: All HIV-1-infected women delivering between 1 January 1997 and 31 December 2010 in the French Perinatal Cohort (ANRS-EPF) were analyzed if they received ART during pregnancy and did not breastfeed. We identified maternal and obstetrical characteristics related to lack of intravenous ZDV and compared its association with MTCT rate and other infant parameters, according to various risk factors. RESULTS: Intravenous ZDV was used in 95.2% of the 11 538 deliveries. Older age, multiparity, and preterm and vaginal delivery were associated with lack of intravenous ZDV (n = 554). In women who delivered with viral load ≥1000 copies/mL, the overall MTCT rate was higher without than with intravenous ZDV (7.5% vs 2.9%; P = .01); however, there was no such difference when the neonate received postnatal intensification therapy. Among them, 77% of women who had viral load

Published
2013

5. Increased risk of serious bacterial infections due to maternal immunosuppression in HIV-exposed uninfected infants in a European country

Author

Marie Medus, Vincent Gajdos, Laure Clech, Céline Goissen, Arnaud Chalvon Demersay, Virginie Zarouk, Louis Bernard, Pierre-François Ceccaldi, René-Charles Rudigoz, Patricia Murger, Philippe Le Moine, Catherine Chirouze, Mandovi Rajguru, Ludovic Cravello, Véronique Lefevre Elbert, Luminata Shneider, Guy Leverger, Tessa Goetghebuer, Kamila Kebaili, Eliane Galiba, Claudine Touboul, Françoise Meier, Didier Tardif, Dieudoné Ekoukou, Michèle Granier, Ahmed Zakaria, Corinne Cudeville, Laurence Benoist, Emilie Piet, Emmanuelle Vintejoux, Yves Hatchuel, Christophe Michau, Jean-Luc Schmidt, Michel Françoise, Claire Briandet, Stéphane Blanche, Philippe Bailly-Salin, Anne Vanderbergh, Jeanne Sibiude, Christiane Kommé, Benoît Martha, Camille Runel-Belliard, Claire Pluchart, Imad Nahri, Vincent Jeantils, François Hervé, Isabelle Hau, Agnès Lefort, Dominique Ayral, Delphine Peretti, Stéphanie Proust, Marie Belloy, Christine Rouzioux, Arnaud Boutet, Philippe Van de Perre, Elisabeth Broustal, Cécile Hafner Mauvais, Thierry Pistone, Marie-Dominique Tabone, Hélène Dauphin, Laurent Cotte, Clement Taron-Brocard, Jean-Marie Lang, Christine Boissinot, Antoine Doumet, André Bongain, Narcisse Elenga, Geneviève Mouchnino, Anne Boutemy, Christine Cheneau, Pascale Perfezou, Pierre Frange, Mathilde Niault, Christelle Dupre, Anne Chacé, Jean-Paul Teglas, Corinne Daniel, Sophie Matheron, Severine Ansart, Martine Levine, Fabienne Caby, Marc Duval-Arnould, Isabelle Metheron, Kareen Billiemaz, Albert Faye, Didier Armangaud, Yamina Hammou, Neila Elaoun, Anne Deville, Philippe Arsac, Lydie Sanchez, Odile Luycx Vaillant, Philippe Lumbroso, Marie-Gisèle Lebrette, Norbert Winer, Elise Maurel, Ramona Abrudan, Luc De Saint Martin, Françoise Jacquier, Christian Calvez, Fabrice Monpoux, Louis Mesnard, Marie-Aude Khuong-Josses, David Rey, Isabelle Belzic, Christine Allisy, Claire Genet, Hervé Seaume, Roland Tubiana, Jacques Reynes, Pascale Nau, Gilles Blondin, Eric Lachassine, Yves Poinsignon, Cédric Arvieux, Leila Karaoui, Anaïs Perilhou, Amélie Benbara, Marine Joras, Sophie Leautez-Nainville, Sophie Ducroix-Roubert, Raghad Moalim, Pascal Bolot, Jacques Gaillat, Olivier Bollengier Stragier, Alain Devidas, Muriel Lalande, Delphine Lemercier, Jean-Pierre Brossier, Emmanuelle Boutard, Isolde Pauly-Ravelly, Marie-Françoise Le Coz, Anne Grelier, Alain Alissa, Christiane De Gennes, Jean-Luc Delassus, Emmanuel Mortier, Faiza Ajana, Ghislaine Firtion, Alain Berrebi, Rose Nguyen, Sarah Ducrocq, Jean-Marc Chamouilli, Fabienne Mazy, Maïa Banigé, Khaled Mohamed, Natacha Entz-Werle, Jacques Brouard, Germaine Bachelard, Sandrine Delmas, Anne Constanty, Véronique Reliquet, Sophie Couderc, Florence Veber, Lahcene Allal, Catherine Crenn-Hebert, Blandine Muanza, Gaelle Pinto-Cardoso, Laurent Mandelbrot, Ama Johnson, Fabienne Messaoudi, Christian Burle, Josiane Warszawski, Bénédicte Carpentier, Dominique Brault, Suzanne Braig, Pascale Fialaire, Corinne Fourcade, Elisabeth Questiaux, Véronique Chambrin, Alain Lafeuillade, Véronique Hentgen, Yves Aubrard, Anne Borgne, Sandrine-Anne Martha, Evelyne Werner, Corinne Floch-Tudal, Agnès Bourgeois Moine, Corinne Routier, Jérôme Le Chenadec, Anne Coursol, Alain Fisher, Amélie Chabrol, Cécile Winter, Cécile Brunet-Cartier, Philippe Labrune, Claudine Cayla, Françoise Mazingue, Virginie Vitrat, Cyril Clavel, Michel Segondy, Ruxandra-Oana Calin, Lise Selleret, Pierre Weinbreck, Zaitoun Abdallah Moussa, Joël Gaudelus, Gaetane Mousset, Thomas Guimard, Agnès Villemant Uludag, Emmanuelle Pannier, Brigitte Clavier, Nicole Ciraru-Vigneron, Alain Checoury, Christophe Elleau, Manuela Bonmarchand, Catherine Dollfus, Joëlle Dendale-Nguyen, Adrien May, Pierre Chevojon, Claire Hubert, Constance Borie, Marialuisa Partisani, Elie Azria, Edouard Vaucel, Erianna Bellaton Marouts, Philippe Moreau, Jean-Luc Esnault, Mahfoud Rouha, Mary-France Courcoux, Brigitte Heller-Roussin, Gilles Hittinger, Christine Rouger, Lanto Ratsimbazafy, Jean-Marc Labaune, Mohamed Abdelhadi, Brigitte Elharrar, Joëlle Tricoire, Eric David, Hassan Safwan, Karine Guimard, Bruno Carbonne, Muriel Barat, Marion Dehlinger-Paul, Stéphane Bounan, Myriam Costa, Estelle Bauville, Didier Pinquier, Valérie Garrait, Etienne Dienga, Odile Launay, Zoha Maakroun, and Dominique Salmon Ceron

Subjects
Microbiology (medical), Pediatrics, medicine.medical_specialty, medicine.medical_treatment, Human immunodeficiency virus (HIV), HIV Infections, Kaplan-Meier Estimate, medicine.disease_cause, Infant, Newborn, Diseases, Pregnancy, medicine, Humans, Pregnancy Complications, Infectious, Retrospective Studies, business.industry, Proportional hazards model, Risk of infection, Hazard ratio, Infant, Newborn, Infant, Immunosuppression, Bacterial Infections, medicine.disease, Confidence interval, Infectious Disease Transmission, Vertical, CD4 Lymphocyte Count, Infectious Diseases, Immunology, Cohort, Female, France, business, Immunosuppressive Agents
Abstract

BACKGROUND Morbidity and mortality are higher among human immunodeficiency virus (HIV) exposed but uninfected (HEU) infants than unexposed infants, particularly if the mother had a low CD4 count. We investigated the possible association between maternal immune depression during pregnancy and the risk of infection in HEU infants in the national French Perinatal Cohort (EPF). METHODS All neonates, born alive, to HIV-1-infected women enrolled in the EPF between 2002 and 2010 were included. The primary outcome was the first serious (hospitalization or death) infection during the first year of life. The main exposure variable was maternal CD4 cell count near delivery. The Kaplan-Meier method and multivariate Cox models were applied, with the different types of infections managed as competing events. RESULTS Among 7638 HEU neonates, 699 had at least 1 serious infection (of which 159 were bacterial) with a Kaplan-Meier probability of 9.3% (95% confidence interval, 8.7-10.0) at 1 year. The risk of serious bacterial infection during the first year of life significantly increased with lower maternal CD4 cell count, before and after adjustment for maternal CD4 cell count

Published
2014

6. Chirurgie plastique esthétique de la face et du cou - Volume 2

Author

Jean-Pierre Bessède, Eric Baggio, Philippe Boudard, Isabelle Catoni, Jean-Baptiste Charrier, Joseph Château, François Disant, Sarah Dufau-Perry, Joëlle Huth, Philippe Kestemont, Justin MICHEL, Thierry Malet, Francesco Perrone, Sylvie Poignonec, Roberto Polselli, Thomas Radulesco, Jean-Marc Ruban, Yves Saban, José Santini, Jean-Marc Thomassin, Florence Turner, Delphine Vertu-Ciolino, Cécile Winter, Jean-Jacques Pessey, Dominique Stoll, Seli ARSLAN, Jean-Pierre Bessède, Eric Baggio, Philippe Boudard, Isabelle Catoni, Jean-Baptiste Charrier, Joseph Château, François Disant, Sarah Dufau-Perry, Joëlle Huth, Philippe Kestemont, Justin MICHEL, Thierry Malet, Francesco Perrone, Sylvie Poignonec, Roberto Polselli, Thomas Radulesco, Jean-Marc Ruban, Yves Saban, José Santini, Jean-Marc Thomassin, Florence Turner, Delphine Vertu-Ciolino, Cécile Winter, Jean-Jacques Pessey, Dominique Stoll, and Seli ARSLAN

Subjects
Surgery, Plastic, Face--Surgery, Neck--Surgery
Abstract

Après la parution de Chirurgie plastique réparatrice de la face et du cou, ce second volume est consacré exclusivement à la chirurgie plastique esthétique. Il apporte un complément indispensable au praticien soucieux d'approfondir ses connaissances. Sont successivement abordés dans ce volume : – la prise en charge du rajeunissement facial et la chirurgie esthétique des paupières ; – les rhinoplasties esthétiques correctrices et fonctionnelles ; – la chirurgie orthognathique de l'adulte et l'esthétique faciale ; – les aspects médicolégaux en chirurgie plastique et esthétique de la face et du cou. Richement illustré, complété de vidéos opératoires en ligne et de nombreux cas cliniques, l'ouvrage, concis et didactique, offre une vision des connaissances pluridisciplinaires indispensables à une prise en charge et une thérapeutique de qualité. Les collaborateurs, praticiens et enseignants, apportent ici toute leur expérience. L'ouvrage s'adresse aux chirurgiens plasticiens, esthétiques, ORL et cervicofaciaux et à tous les spécialistes de chirurgie plastique et esthétique de la face et du cou. Pour accéder au complément en ligne de cet ouvrage, cliquez ici.

Published
2012

7. There is only one world

Author

Chakib Allaoui, Cécile Winter, and Isabelle Auperin

Subjects
Infectious Diseases, Geography, Immunology, Immunology and Allergy
Published
2008

8. Courrier adressé auxTemps Modernes

Author

Cécile Winter

Subjects
Cultural Studies, History, Literature and Literary Theory, Sociology and Political Science, media_common.quotation_subject, Art, Humanities, media_common
Published
2006

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