4 results on '"Cécile Fruchard"'
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2. Evidence for Dosage Compensation in Coccinia grandis, a Plant With a Highly Heteromorphic XY System
- Author
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Abdelhafid Bendahmane, Susanne S. Renner, Cécile Fruchard, Aline Muyle, Ravi Suresh Devani, Gabriel A. B. Marais, Anjan K. Banerjee, David Latrasse, Bénédicte Rhoné, Hélène Badouin, Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Institut des Sciences des Plantes de Paris-Saclay (IPS2 (UMR_9213 / UMR_1403)), Université d'Évry-Val-d'Essonne (UEVE)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Indian Institute of Science Education and Research Pune (IISER Pune), University of California [Irvine] (UC Irvine), University of California (UC), Institut de Recherche pour le Développement (IRD [France-Sud]), Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), Université d'Évry-Val-d'Essonne (UEVE)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of California [Irvine] (UCI), University of California, and Technical University of Munich (TUM)
- Subjects
0106 biological sciences ,0301 basic medicine ,Coccinia grandis ,food.ingredient ,lcsh:QH426-470 ,Dioecy ,[SDV]Life Sciences [q-bio] ,Single-nucleotide polymorphism ,Flowers ,Biology ,01 natural sciences ,Article ,Chromosomes, Plant ,sex-biased genes ,Evolution, Molecular ,03 medical and health sciences ,food ,cucurbits ,Molecular evolution ,Gene Expression Regulation, Plant ,Dosage Compensation, Genetic ,Gene expression ,Genetics ,Silene latifolia ,Humans ,Gene ,Genetics (clinical) ,Dosage compensation ,sex chromosomes ,Sex Determination Processes ,biology.organism_classification ,Y degeneration ,dioecy ,Cucurbitaceae ,lcsh:Genetics ,030104 developmental biology ,010606 plant biology & botany - Abstract
About 15,000 angiosperms are dioecious, but the mechanisms of sex determination in plants remain poorly understood. In particular, how Y chromosomes evolve and degenerate, and whether dosage compensation evolves as a response, are matters of debate. Here, we focus on Coccinia grandis, a dioecious cucurbit with the highest level of X/Y heteromorphy recorded so far. We identified sex-linked genes using RNA sequences from a cross and a model-based method termed SEX-DETector. Parents and F1 individuals were genotyped, and the transmission patterns of SNPs were then analyzed. In the >, 1300 sex-linked genes studied, maximum X-Y divergence was 0.13&ndash, 0.17, and substantial Y degeneration is implied by an average Y/X expression ratio of 0.63 and an inferred gene loss on the Y of ~40%. We also found reduced Y gene expression being compensated by elevated expression of corresponding genes on the X and an excess of sex-biased genes on the sex chromosomes. Molecular evolution of sex-linked genes in C. grandis is thus comparable to that in Silene latifolia, another dioecious plant with a strongly heteromorphic XY system, and cucurbits are the fourth plant family in which dosage compensation is described, suggesting it might be common in plants.
- Published
- 2020
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3. Evidence for dosage compensation in Coccinia grandis, a plant with a highly heteromorphic XY system
- Author
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Susanne S. Renner, Ravi Suresh Devani, Abdelhafid Bendahmane, Anjan K. Banerjee, Aline Muyle, Bénédicte Rhoné, David Latrasse, Cécile Fruchard, Hélène Badouin, and Gabriel A. B. Marais
- Subjects
Genetics ,Coccinia grandis ,food.ingredient ,food ,Dosage compensation ,Molecular evolution ,Gene expression ,RNA ,Silene latifolia ,Single-nucleotide polymorphism ,Biology ,biology.organism_classification ,Gene - Abstract
Some ~15.000 angiosperms are dioecious, but mechanisms of sex determination in plants remain poorly understood. In particular, how Y chromosomes evolve and degenerate, and whether dosage compensation evolves as a response, are matters of debate. Here we focus on Coccinia grandis, a dioecious cucurbit with the highest level of X/Y heteromorphy recorded so far. We identified sex-linked genes using RNA sequences from a cross and a model-based method termed SEX-DETector. Parents and F1 individuals were genotyped and the transmission patterns of SNPs then analysed. In the >1300 sex-linked genes studied, X-Y divergence was 0.13 - 0.17, and substantial Y degeneration is implied by an average Y/X expression ratio of 0.63 and an inferred gene loss on the Y of ~40%. We also found reduced Y gene expression being compensated by elevated expression of corresponding genes on the X and an excess of sex-biased genes on the sex chromosomes. Molecular evolution of sex-linked genes in C. grandis is thus comparable to that in Silene latifolia, another dioecious plant with a strongly heteromorphic XY system, and cucurbits are the fourth plant family in which dosage compensation is described, suggesting it might be common in plants.
- Published
- 2020
- Full Text
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4. Genomic imprinting mediates dosage compensation in a young plant XY system.: An article peer-reviewed and recommended by Peer Community In Evolutionary Biology (PCI Evol Biol)
- Author
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Nicklaus Zemp, Raquel Tavares, Radim Cegan, Jan Vrána, Aline Muyle, Franck Picard, Alex Widmer, Roman Hobza, Cécile Fruchard, Gabriel A. B. Marais, Clothilde Deschamps, Sexe et évolution, Département PEGASE [LBBE] (PEGASE), Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Genetic Diversity Center [ETH Zurich] (GDC), Department of Environmental Systems Science [ETH Zürich] (D-USYS), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology in Zürich [Zürich] (ETH Zürich)-Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology in Zürich [Zürich] (ETH Zürich), Institute of Biophysics of the Czech Academy of Sciences, Brno, Laboratory of Molecular Cytogenetics and Cytometry, Institute of Experimental Botany of the ASCR, Pôle Rhône-Alpin de BioInformatique [Lyon] (PRABI), Université de Lyon-Université de Lyon, Statistique en grande dimension pour la génomique, Institut de Génomique Fonctionnelle de Lyon (IGFL), École normale supérieure - Lyon (ENS Lyon)-Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich)- Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Institute of Genomics and Integrative Biology, Institute of Biophysics of the Czech Academy of Sciences (IBP / CAS), Czech Academy of Sciences [Prague] (CAS), Centre of the Region Hana for Biotechnological and Agricultural Research, Institute of Experimental Botany of the Czech Academy of Sciences (IEB / CAS), Czech Academy of Sciences [Prague] (CAS)-Czech Academy of Sciences [Prague] (CAS), Centre of the Region Haná for Biotechnological and Agricultural Research [Univ Palacký] (CRH), Faculty of Science [Univ Palacký], Palacky University Olomouc-Palacky University Olomouc-Institute of Experimental Botany of the Czech Academy of Sciences (IEB / CAS), Institute of Integrative Biology (IBZ), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Czech Academy of Sciences [Prague] (CAS)-Czech Academy of Sciences [Prague] (CAS)-Faculty of Science [Univ Palacký], and École normale supérieure de Lyon (ENS de Lyon)-Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL)
- Subjects
0106 biological sciences ,0301 basic medicine ,[SDV]Life Sciences [q-bio] ,Plant Science ,[SDV.BID]Life Sciences [q-bio]/Biodiversity ,Biology ,010603 evolutionary biology ,01 natural sciences ,Genome ,Chromosomes, Plant ,X-inactivation ,[SDV.GEN.GPL]Life Sciences [q-bio]/Genetics/Plants genetics ,Genomic Imprinting ,03 medical and health sciences ,Downregulation and upregulation ,Gene Expression Regulation, Plant ,Dosage Compensation, Genetic ,Silene latifolia ,[SDV.BV]Life Sciences [q-bio]/Vegetal Biology ,Imprinting (psychology) ,Silene ,Animal species ,Gene ,X chromosome ,ComputingMilieux_MISCELLANEOUS ,030304 developmental biology ,Genetics ,0303 health sciences ,[SDV.GEN]Life Sciences [q-bio]/Genetics ,Sex Chromosomes ,Dosage compensation ,Autosome ,[SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] ,XY sex-determination system ,biology.organism_classification ,[SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM] ,030104 developmental biology ,[SDE]Environmental Sciences ,[SDE.BE]Environmental Sciences/Biodiversity and Ecology ,Genomic imprinting ,010606 plant biology & botany - Abstract
This preprint has been reviewed and recommended by Peer Community In Evolutionary Biology (http://dx.doi.org/10.24072/pci.evolbiol.100044).Sex chromosomes have repeatedly evolved from a pair of autosomes1. Consequently, X and Y chromosomes initially have similar gene content, but ongoing Y degeneration leads to reduced Y gene expression and eventual Y gene loss. The resulting imbalance in gene expression between Y genes and the rest of the genome is expected to reduce male fitness, especially when protein networks have components from both autosomes and sex chromosomes. A diverse set of dosage compensating mechanisms that alleviates these negative effects has been described in animals2–4. However, the early steps in the evolution of dosage compensation remain unknown and dosage compensation is poorly understood in plants5. Here we show a novel dosage compensation mechanism in the evolutionarily young XY sex determination system of the plant Silene latifolia. Genomic imprinting results in higher expression from the maternal X chromosome in both males and females. This compensates for reduced Y expression in males but results in X overexpression in females and may be detrimental. It could represent a transient early stage in the evolution of dosage compensation. Our finding has striking resemblance to the first stage proposed by Ohno for the evolution of X inactivation in mammals.
- Published
- 2018
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