39 results on '"Cárdenas-Valladolid J"'
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2. Incidence of T2DM and the role of baseline glycaemic status as a determinant in a metropolitan population in northern Madrid (Spain)
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Iriarte-Campo, V., de Burgos-Lunar, C., Mostaza, J., Lahoz, C., Cárdenas-Valladolid, J., Gómez-Campelo, P., Taulero-Escalera, B., San-Andrés-Rebollo, F.J., Rodriguez-Artalejo, F., and Salinero-Fort, M.A.
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- 2024
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3. Factors associated with mortality due to SARS-CoV-2 in the population over 75 years of age in the Community of Madrid
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Mostaza, J.M., Salinero-Fort, M.A., Cardenas-Valladolid, J., Rodríguez-Artalejo, F., Díaz-Almirón, M., Vich-Pérez, P., San Andrés-Rebollo, F.J., Vicente, I., and Lahoz, C.
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- 2022
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4. Factores asociados con la mortalidad por SARS-CoV-2 en la población mayor de 75 años de la Comunidad de Madrid
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Mostaza, J.M., Salinero-Fort, M.A., Cardenas-Valladolid, J., Rodríguez-Artalejo, F., Díaz-Almirón, M., Vich-Pérez, P., San Andrés-Rebollo, F.J., Vicente, I., and Lahoz, C.
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- 2022
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5. All-cause mortality and cardiovascular events in a Spanish nonagenarian cohort according to type 2 diabetes mellitus status and established cardiovascular disease
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Salinero-Fort, MA, Mostaza, J., Lahoz, C., Cárdenas-Valladolid, J., Vicente-Díez, J. I., Gómez-Campelo, P., and de Miguel-Yanes, J. M.
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- 2022
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6. Author Correction: Cardiovascular risk factors associated with acute myocardial infarction and stroke in the MADIABETES cohort
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Salinero-Fort, M. A., Andrés-Rebollo, F. J. San, Cárdenas-Valladolid, J., Méndez-Bailón, M., Chico-Moraleja, R. M., de Santa Pau, E. Carrillo, Jiménez-Trujillo, I., Gómez-Campelo, I., de Burgos Lunar, C., and de Miguel-Yanes, J. M.
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- 2022
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7. Effect of depression on mortality in type 2 diabetes mellitus after 8 years of follow-up. The DIADEMA study
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Salinero-Fort, M.A., Gómez-Campelo, P., Cárdenas-Valladolid, J., San Andrés-Rebollo, F.J., de Miguel-Yanes, J.M., and de Burgos-Lunar, C.
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- 2021
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8. Cardiovascular risk factors associated with acute myocardial infarction and stroke in the MADIABETES cohort
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Salinero-Fort, M. A., Andrés-Rebollo, F. J. San, Cárdenas-Valladolid, J., Méndez-Bailón, M., Chico-Moraleja, R. M., de Santa Pau, E. Carrillo, Jiménez-Trujillo, I., Gómez-Campelo, I., de Burgos Lunar, C., and de Miguel-Yanes, J. M.
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- 2021
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9. Body mass index and all-cause mortality among type 2 diabetes mellitus patients: Findings from the 5-year follow-up of the MADIABETES cohort
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Salinero-Fort, M.A., San Andrés-Rebollo, F.J., Gómez-Campelo, P., de Burgos-Lunar, C., Cárdenas-Valladolid, J., Abánades-Herranz, J.C., Otero-Puime, A., Jiménez-García, R., López-de-Andrés, A., and de Miguel-Yanes, J.M.
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- 2017
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10. Real-world data in primary care: validation of diagnosis of atrial fibrillation in primary care electronic medical records and estimated prevalence
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de Burgos-Lunar, C, primary, Cura-González, I del, additional, Cárdenas-Valladolid, J, additional, Gómez-Campelo, P, additional, Abánades-Herranz, JC, additional, de-Andrés, A López, additional, Sotos-Prieto, M, additional, Iriarte-Campo, V, additional, and Salinero-Fort, MA, additional
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- 2022
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11. Effectiveness of standardized nursing care plans to achieve A1C, blood pressure, and LDL-C goals among people with poorly controlled type 2 diabetes mellitus at baseline: four-year follow-up study
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Cárdenas-Valladolid, J., López-de Andrés, A., Jiménez-García, R., de Dios-Duarte, M. J., Gómez-Campelo, P., de Burgos-Lunar, C., San Andrés-Rebollo, F. J., Abánades-Herranz, J. C., and Salinero-Fort, M. A.
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- 2018
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12. Proyecto de mejora del Proceso de Atención Continuada domiciliaria en Atención Primaria: rediseño y AMFE
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Cañada Dorado, A., Cárdenas Valladolid, J., Espejo Matorrales, F., García Ferradal, I., Sastre Páez, S., and Vicente Martín, I.
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- 2010
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13. All-Cause Mortality And Cardiovascular Events In A Spanish Nonagenarian Cohort According To Type 2 Diabetes Mellitus Status And Established Cardiovascular Disease
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Salinero-Fort, MA, primary, Mostaza-Prieto, J, additional, Lahoz-Rallo, C, additional, Cárdenas-Valladolid, J, additional, Vicente-Díez, JI, additional, Gómez-Campelo, P, additional, and de Miguel-Yanes, JM, additional
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- 2021
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14. Riesgo basal de Diabetes Mellitus en Atención Primaria según cuestionario FINDRISC, factores asociados y evolución clínica tras 18 meses de seguimiento
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Salinero-Fort, M.A., Carrillo-de Santa Pau, E., Abánades-Herranz, J.C., Dujovne-Kohan, I., and Cárdenas-Valladolid, J.
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- 2010
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15. Prevalence of adherence to treatment in homebound elderly people in primary health care: a descriptive, cross-sectional, multicentre study.
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Cárdenas-Valladolid J, Martín-Madrazo C, Salinero-Fort MA, de-Santa Pau EC, Abánades-Herranz JC, and de Burgos-Lunar C
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Background: Adherence to the therapeutic plan is one of the most important health issues in terms of treatment efficacy, healthcare costs and patient safety. Unfortunately, homebound elderly patients are especially vulnerable to nonadherence because they have higher morbidity rates combined with cognitive and social problems that hinder their correct use of drugs. The level of therapeutic adherence in homebound elderly people has not been adequately studied. Objective: To estimate the prevalence of therapeutic adherence, using the Morisky-Green test, in homebound elderly patients taking polypharmacy (defined as use of four or more drugs), and to study the factors associated with adherence. Methods: This was a descriptive, cross-sectional, multicentre study. A total of 327 patients were selected by random start systematic sampling from the total number of homebound patients taking four or more drugs in Healthcare Area 4 of the Madrid Autonomous Region, Spain. Through an in-home survey of patients and their caregivers, information was gathered on sociodemographic data, co-morbidities, number of hospital admissions, responsibility for purchasing and preparation of the medication, level of cognitive impairment (Pfeiffer questionnaire), functional dependence in activities of daily living (Katz Index), knowledge of the disease (Batalla test), adherence to treatment (Morisky-Green test), visual and auditory perception, and caregiver burden (Zarit interview). Results: Of the homebound patients, 65.7% (95% CI 60.6, 70.9) had good adherence to treatment. The variables most negatively associated with therapeutic adherence, after adjustment for age, sex, number of drugs, knowledge of the disease, and cognitive function, were a large caregiver burden (odds ratio [OR] 3.09; 95% CI 1.75, 5.48) and impaired hearing (OR 2.00; 95% CI 1.17, 3.40). There was also a trend toward a positive association between nonadherence and patients aged <85 years (OR 1.57; 95% CI 0.93, 2.65) and patients who had nine or more drug prescriptions (OR 1.59; 95% CI 0.96, 2.65). Conclusions: Poor therapeutic adherence in homebound elderly patients receiving polypharmacy is a serious problem affecting one of every three individuals concerned, and is directly related to caregiver burden, regardless of age, sex, cognitive status or number of drugs administered. [ABSTRACT FROM AUTHOR]
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- 2010
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16. Effect of depression on mortality and cardiovascular morbidity in type 2 diabetes mellitus after 3 years follow up. The DIADEMA study protocol
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de Burgos-Lunar Carmen, Gómez-Campelo Paloma, Cárdenas-Valladolid Juan, Fuentes-Rodríguez Carmen Y, Granados-Menéndez María I, López-López Francisco, and Salinero-Fort Miguel A
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Depression ,Diabetes mellitus ,Type 2 ,Primary health care ,Psychiatry ,RC435-571 - Abstract
Abstract Background Type 2 diabetes mellitus and depression are highly prevalent diseases that are associated with an increased risk of cardiovascular disease and mortality. There is evidence about a bidirectional association between depressive symptoms and type 2 diabetes mellitus. However, prognostic implications of the joint effects of these two diseases on cardiovascular morbidity and mortality are not well-known. Method/design A three-year, observational, prospective, cohort study, carried out in Primary Health Care Centres in Madrid (Spain). The project aims to analyze the effect of depression on cardiovascular events, all-cause and cardiovascular mortality in patients with type 2 diabetes mellitus, and to estimate a clinical predictive model of depression in these patients. The number of patients required is 3255, all them with type 2 diabetes mellitus, older than 18 years, who regularly visit their Primary Health Care Centres and agree to participate. They are chosen by simple random sampling from the list of patients with type 2 diabetes mellitus of each general practitioner. The main outcome measures are all-cause and cardiovascular mortality and cardiovascular morbidity; and exposure variable is the major depressive disorder. There will be a comparison between depressed and not depressed patients in all-cause mortality, cardiovascular mortality, coronary artery disease and stroke using the Chi-squared test. Logistic regression with random effects will be used to adjust for prognostic factors. Confounding factors that might alter the effect recorded will be taken into account in this analysis. To assess the effect of depression on the mortality, a survival analysis will be used comparing the two groups using the log-rank test. The control of potential confounding variables will be performed by the construction of a Cox regression model. Discussion Our study’s main contribution is to evaluate the increase in the risk of cardiovascular morbidity and mortality, in depressed Spanish adults with type 2 diabetes mellitus attended in Primary Health Care Setting. It would also be useful to identify subgroups of patients for which the interventions could be more beneficial.
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- 2012
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17. Validation of diabetes mellitus and hypertension diagnosis in computerized medical records in primary health care
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Abánades-Herranz Juan C, Fuentes-Rodríguez Carmen Y, Soto-Díaz Sonia, Cárdenas-Valladolid Juan, Salinero-Fort Miguel A, de Burgos-Lunar Carmen, and del Cura-González Isabel
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Medicine (General) ,R5-920 - Abstract
Abstract Background Computerized Clinical Records, which are incorporated in primary health care practice, have great potential for research. In order to use this information, data quality and reliability must be assessed to prevent compromising the validity of the results. The aim of this study is to validate the diagnosis of hypertension and diabetes mellitus in the computerized clinical records of primary health care, taking the diagnosis criteria established in the most prominently used clinical guidelines as the gold standard against which what measure the sensitivity, specificity, and determine the predictive values. The gold standard for diabetes mellitus was the diagnostic criteria established in 2003 American Diabetes Association Consensus Statement for diabetic subjects. The gold standard for hypertension was the diagnostic criteria established in the Joint National Committee published in 2003. Methods A cross-sectional multicentre validation study of diabetes mellitus and hypertension diagnoses in computerized clinical records of primary health care was carried out. Diagnostic criteria from the most prominently clinical practice guidelines were considered for standard reference. Sensitivity, specificity, positive and negative predictive values, and global agreement (with kappa index), were calculated. Results were shown overall and stratified by sex and age groups. Results The agreement for diabetes mellitus with the reference standard as determined by the guideline was almost perfect (κ = 0.990), with a sensitivity of 99.53%, a specificity of 99.49%, a positive predictive value of 91.23% and a negative predictive value of 99.98%. Hypertension diagnosis showed substantial agreement with the reference standard as determined by the guideline (κ = 0.778), the sensitivity was 85.22%, the specificity 96.95%, the positive predictive value 85.24%, and the negative predictive value was 96.95%. Sensitivity results were worse in patients who also had diabetes and in those aged 70 years or over. Conclusions Our results substantiate the validity of using diagnoses of diabetes and hypertension found within the computerized clinical records for epidemiologic studies.
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- 2011
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18. Effect of glucose variability on the mortality of adults aged 75 years and over during the first year of the COVID-19 pandemic.
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Salinero-Fort MA, San Andrés-Rebollo FJ, Cárdenas-Valladolid J, Mostaza J, Lahoz C, Rodriguez-Artalejo F, Gómez-Campelo P, Vich-Pérez P, Jiménez-García R, de-Miguel-Yanes JM, Maroto-Rodriguez J, Taulero-Escalera B, and Campo VI
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- Humans, Female, Male, Aged, 80 and over, Aged, Retrospective Studies, Glycated Hemoglobin metabolism, Glycated Hemoglobin analysis, Diabetes Mellitus mortality, Diabetes Mellitus blood, Diabetes Mellitus epidemiology, Pandemics, Spain epidemiology, Mortality trends, SARS-CoV-2, Cause of Death trends, COVID-19 mortality, COVID-19 epidemiology, COVID-19 blood, Blood Glucose metabolism, Blood Glucose analysis
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Background: To our knowledge, only one study has examined the association between glucose variability (GV) and mortality in the elderly population with diabetes. GV was assessed by HbA1c, and a J-shaped curve was observed in the relationship between HbA1c thresholds and mortality. No study of GV was conducted during the COVID-19 pandemic and its lockdown. This study aims to evaluate whether GV is an independent predictor of all-cause mortality in patients aged 75 years or older with and without COVID-19 who were followed during the first year of the COVID-19 pandemic and its lockdown measures., Methods: This was a retrospective cohort study of 407,492 patients from the AGED-MADRID dataset aged 83.5 (SD 5.8) years; 63.2% were women, and 29.3% had diabetes. GV was measured by the coefficient of variation of fasting plasma glucose (CV-FPG) over 6 years of follow-up (2015-2020). The outcome measure was all-cause mortality in 2020. Four models of logistic regression were performed, from simple (age, sex) to fully adjusted, to assess the effect of CV-FPG on all-cause mortality., Results: During follow-up, 34,925 patients died (14,999 women and 19,926 men), with an all-cause mortality rate of 822.3 per 10,000 person-years (95% confidence interval (CI), 813.7 to 822.3) (739 per 10,000; 95% CI 728.7 to 739.0 in women and 967.1 per 10,000; 95% CI 951.7 to 967.2 in men). The highest quartile of CV-FPG was significantly more common in the deceased group (40.1% vs. 23.6%; p < 0.001). In the fully adjusted model including dementia (Alzheimer's disease) and basal FPG, the odds ratio for mortality ranged from 1.88 to 2.06 in patients with T2DM and from 2.30 to 2.61 in patients with normoglycaemia, according to different sensitivity analyses., Conclusions: GV has clear implications for clinical practice, as its assessment as a risk prediction tool should be included in the routine follow-up of the elderly and in a comprehensive geriatric assessment. Electronic health records can incorporate tools that allow its calculation, and with this information, clinicians will have a broader view of the medium- and long-term prognosis of their patients., (© 2024. The Author(s).)
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- 2024
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19. External validation of three diabetes prediction scores in a Spanish cohort: does adding high risk for depression improve the validation of the FINDRISC score (FINDRISC-MOOD)?
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Salinero-Fort M, Mostaza-Prieto JM, Lahoz-Rallo C, Cárdenas-Valladolid J, Iriarte-Campo V, Estirado-Decabo E, Garcia-Iglesias F, Gonzalez-Alegre T, Fernandez-Puntero B, Cornejo-Del Rio VM, Sanchez-Arroyo V, Sabín-Rodríguez C, López-López S, Gómez-Campelo P, Taulero-Escalera B, Rodriguez-Artalejo F, San Andrés-Rebollo FJ, and De Burgos-Lunar C
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- Humans, Female, Spain, Male, Middle Aged, Prospective Studies, Aged, Risk Assessment methods, Risk Factors, Blood Glucose analysis, Blood Glucose metabolism, Diabetes Mellitus epidemiology, Diabetes Mellitus diagnosis, Diabetes Mellitus blood, Diabetes Mellitus, Type 2 diagnosis, Diabetes Mellitus, Type 2 blood, Diabetes Mellitus, Type 2 epidemiology, Surveys and Questionnaires, ROC Curve, Patient Health Questionnaire, Depression diagnosis, Depression epidemiology, Glucose Tolerance Test
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Objectives: To evaluate the external validity of the FINDRISC, DESIR and ADA risk scores for the prediction of diabetes in a Spanish population aged >45 years and to test the possible improvement of FINDRISC by adding a new variable of high risk of depression when Patient Health Questionnaire-9 (PHQ-9) questionnaire score ≥10 (FINDRISC-MOOD)., Design: Prospective population-based cohort study., Setting: 10 primary healthcare centres in the north of the city of Madrid (Spain)., Participants: A total of 1242 participants without a history of diabetes and with 2-hour oral glucose tolerance test (OGTT) plasma glucose <200 mg/dL (<11.1 mmol/L) were followed up for 7.3 years (median) using their electronic health records (EHRs) and telephone contact., Primary and Secondary Outcome Measures: Diabetes risk scores (FINDRISC, DESIR, ADA), PHQ-9 questionnaire and 2-hour-OGTT were measured at baseline. Incident diabetes was defined as treatment for diabetes, fasting plasma glucose ≥126 mg/dL (≥7.0 mmol/L), new EHR diagnosis or self-reported diagnosis. External validation was performed according to optimal cut-off, sensitivity, specificity and Youden Index. Comparison between diabetes risk scores, including FINDRISC-MOOD (original FINDRISC score plus five points if PHQ-9 ≥10), was measured by area under the receiver operating characteristic curve (AUROC)., Results: During follow-up, 104 (8.4%; 95% CI, 6.8 to 9.9) participants developed diabetes and 185 had a PHQ-9 score ≥10. The AUROC values were 0.70 (95% CI, 0.67 to 0.72) for FINDRISC-MOOD and 0.68 (95% CI, 0.65 to 0.71) for the original FINDRISC. The AUROCs for DESIR and ADA were 0.66 (95% CI, 0.63 to 0.68) and 0.66 (95% CI, 0.63 to 0.69), respectively. There were no significant differences in AUROC between FINDRISC-MOOD and the other scores., Conclusions: The results of FINDRISC-MOOD were like those of the other risk scores and do not allow it to be recommended for clinical use., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2024
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20. Cross-sectional Association Between Plasma Biomarkers and Multimorbidity Patterns in Older Adults.
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Vázquez-Fernández A, Lana A, Struijk EA, Vega-Cabello V, Cárdenas-Valladolid J, Salinero-Fort MÁ, Rodríguez-Artalejo F, Lopez-Garcia E, and Caballero FF
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- Humans, Aged, Cross-Sectional Studies, Biomarkers, Amino Acids, Cholesterol, HDL, Multimorbidity, Cardiovascular Diseases
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Multimorbidity is the simultaneous presence of 2 or more chronic conditions. Metabolomics could identify biomarkers potentially related to multimorbidity. We aimed to identify groups of biomarkers and their association with different multimorbidity patterns. Cross-sectional analyses were conducted within the Seniors-ENRICA-2 cohort in Spain, with information from 700 individuals aged ≥65 years. Biological samples were analyzed using high-throughput proton nuclear magnetic resonance metabolomics. Biomarker groups were identified with exploratory factor analysis, and multimorbidity was classified into 3 types: cardiometabolic, neuropsychiatric, and musculoskeletal. Logistic regression was used to estimate the association between biomarker groups and multimorbidity patterns, after adjusting for potential confounders including sociodemographics, lifestyle, and body mass index. Three factors were identified: the "lipid metabolism" mainly reflected biomarkers related to lipid metabolism, such as very-low-density lipoprotein and low-density lipoprotein cholesterol; the "high-density lipoprotein cholesterol" mainly included high-density lipoprotein cholesterol subclasses and other lipids not included in the first factor; and the "amino acid/glycolysis/ketogenesis," composed of some amino acids, glycolysis-related metabolites, and ketone bodies. Higher scores in the "lipid metabolism" factor were associated with a higher likelihood of cardiometabolic multimorbidity, odds ratio for tertile 3 versus tertile 1 was 1.79 (95% confidence interval: 1.17-2.76). The "high-density lipoprotein cholesterol" factor was associated with lower odds of cardiometabolic multimorbidity [0.51 (0.32-0.82)], and the "amino acid/glycolysis/ketogenesis" factor was associated with more frequent cardiometabolic multimorbidity [1.85 (1.18-2.90)]. Different metabolomic biomarkers are associated with different multimorbidity patterns; therefore, multiple biomarker measurements are needed for a complete picture of the molecular mechanisms of multimorbidity., (© The Author(s) 2023. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
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- 2024
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21. Prospective Association Between Plasma Concentrations of Fatty Acids and Other Lipids, and Multimorbidity in Older Adults.
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Caballero FF, Lana A, Struijk EA, Arias-Fernández L, Yévenes-Briones H, Cárdenas-Valladolid J, Salinero-Fort MÁ, Banegas JR, Rodríguez-Artalejo F, and Lopez-Garcia E
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- Humans, Aged, Sphingomyelins, Prospective Studies, Fatty Acids, Omega-6, Glycerophospholipids, Phosphatidylcholines, Chronic Disease, Multimorbidity, Fatty Acids
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Biological mechanisms that lead to multimorbidity are mostly unknown, and metabolomic profiles are promising to explain different pathways in the aging process. The aim of this study was to assess the prospective association between plasma fatty acids and other lipids, and multimorbidity in older adults. Data were obtained from the Spanish Seniors-ENRICA 2 cohort, comprising noninstitutionalized adults ≥65 years old. Blood samples were obtained at baseline and after a 2-year follow-up period for a total of 1 488 subjects. Morbidity was also collected at baseline and end of the follow-up from electronic health records. Multimorbidity was defined as a quantitative score, after weighting morbidities (from a list of 60 mutually exclusive chronic conditions) by their regression coefficients on physical functioning. Generalized estimating equation models were employed to assess the longitudinal association between fatty acids and other lipids, and multimorbidity, and stratified analyses by diet quality, measured with the Alternative Healthy Eating Index-2010, were also conducted. Among study participants, higher concentrations of omega-6 fatty acids [coef. per 1-SD increase (95% CI) = -0.76 (-1.23, -0.30)], phosphoglycerides [-1.26 (-1.77, -0.74)], total cholines [-1.48 (-1.99, -0.96)], phosphatidylcholines [-1.23 (-1.74, -0.71)], and sphingomyelins [-1.65 (-2.12, -1.18)], were associated with lower multimorbidity scores. The strongest associations were observed for those with a higher diet quality. Higher plasma concentrations of omega-6 fatty acids, phosphoglycerides, total cholines, phosphatidylcholines, and sphingomyelins were prospectively associated with lower multimorbidity in older adults, although diet quality could modulate the associations found. These lipids may serve as risk markers for multimorbidity., (© The Author(s) 2023. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
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- 2023
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22. Validation of diagnosis of acute myocardial infarction and stroke in electronic medical records: a primary care cross-sectional study in Madrid, Spain (the e-MADVEVA Study).
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de Burgos-Lunar C, Del Cura-Gonzalez I, Cárdenas-Valladolid J, Gómez-Campelo P, Abánades-Herranz JC, Lopez-de-Andres A, Sotos-Prieto M, Iriarte-Campo V, Fuentes-Rodriguez CY, Gómez-Coronado R, and Salinero-Fort MA
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- Humans, Adult, Middle Aged, Adolescent, Cross-Sectional Studies, Electronic Health Records, Spain, Patient Discharge, Stroke, Myocardial Infarction
- Abstract
Objectives: To validate the diagnoses of acute myocardial infarction (AMI) and stroke recorded in electronic medical records (EMR) and to estimate the population prevalence of both diseases in people aged ≥18 years., Design: Cross-sectional validation study., Setting: 45 primary care centres., Participants: Simple random sampling of diagnoses of AMI and stroke (International Classification of Primary Care-2 codes K75 and K90, respectively) registered by 55 physicians and random age-matched and sex-matched sampling of the records that included in primary care EMRs in Madrid (Spain)., Primary and Secondary Outcome Measures: Sensitivity, specificity, positive and negative predictive values and overall agreement were calculated using the kappa statistic. Applied gold standards were ECGs, brain imaging studies, hospital discharge reports, cardiology reports and neurology reports. In the case of AMI, the ESC/ACCF/AHA/WHF Expert Consensus Document was also used. Secondary outcomes were the estimated prevalence of both diseases considering the sensitivity and specificity obtained (true prevalence)., Results: The sensitivity of a diagnosis of AMI was 98.11% (95% CI, 96.29 to 99.03), and the specificity was 97.42% (95% CI, 95.44 to 98.55). The sensitivity of a diagnosis of stroke was 97.56% (95% CI, 95.56 to 98.68), and the specificity was 94.51% (95% CI, 91.96 to 96.28). No differences in the results were found after stratification by age and sex (both diseases). The prevalence of AMI and stroke was 1.38% and 1.27%, respectively., Conclusion: The validation results show that diagnoses of AMI and stroke in primary care EMRs constitute a helpful tool in epidemiological studies. The prevalence of AMI and stroke was lower than 2% in the population aged over 18 years., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2023
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23. Prospective Association Between Plasma Amino Acids and Multimorbidity in Older Adults.
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Caballero FF, Lana A, Struijk EA, Arias-Fernández L, Yévenes-Briones H, Cárdenas-Valladolid J, Salinero-Fort MÁ, Banegas JR, Rodríguez-Artalejo F, and Lopez-Garcia E
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- Humans, Female, Aged, Male, Glutamine, Multimorbidity, Valine, Chronic Disease, Amino Acids, Isoleucine
- Abstract
Background: Some amino acids have been associated with aging-related disorders and risk of physical impairment. The aim of this study was to assess the association between plasma concentrations of 9 amino acids, including branched-chain and aromatic amino acids, and multimorbidity., Methods: This research uses longitudinal data from the Seniors-ENRICA 2 study, a population-based cohort from Spain that comprises noninstitutionalized adults older than 65. Blood samples were extracted at baseline and after a follow-up period of 2 years for a total of 1 488 subjects. Participants' information was linked with electronic health records. Chronic diseases were grouped into a list of 60 mutually exclusive conditions. A quantitative measure of multimorbidity, weighting morbidities by their regression coefficients on physical functioning, was employed and ranged from 0 to 100. Generalized estimating equation models were used to explore the relationship between plasma amino acids and multimorbidity, adjusting for sociodemographics, socioeconomic status, and lifestyle behaviors., Results: The mean age of participants at baseline was 73.6 (SD = 4.2) years, 49.6% were women. Higher concentrations of glutamine (coef. per mmol/l [95% confidence interval] = 10.1 [3.7, 16.6]), isoleucine (50.3 [21.7, 78.9]), and valine (15.5 [3.1, 28.0]) were significantly associated with higher multimorbidity scores, after adjusting for potential confounders. Body mass index could have influenced the relationship between isoleucine and multimorbidity (p = .016)., Conclusions: Amino acids could play a role in regulating aging-related diseases. Glutamine and branched-chain amino acids as isoleucine and valine are prospectively associated and could serve as risk markers for multimorbidity in older adults., (© The Author(s) 2022. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
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- 2023
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24. Multimorbidity Patterns in Older Adults: the Role of Social Variables and Lifestyle Behaviors.
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Caballero FF, Lana A, Struijk EA, Arias-Fernández L, Cárdenas-Valladolid J, Salinero-Fort MÁ, Banegas JR, Rodríguez-Artalejo F, and Lopez-García E
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- Humans, Male, Female, Aged, Multimorbidity, Cross-Sectional Studies, Life Style, Chronic Disease, Prevalence, Cardiovascular Diseases epidemiology, Musculoskeletal Diseases complications
- Abstract
Introduction: While some condition clusters represent the chance co-occurrence of common individual conditions, others may represent shared causal factors. The aims of this study were to identify multimorbidity patterns in older adults and to explore the relationship between social variables, lifestyle behaviors, and the multimorbidity patterns identified., Methods: This was a cross-sectional design. Data came from 3,273 individuals aged ≥65 from the Seniors-ENRICA-2 cohort; information on 60 chronic disease categories, categorized according to the 2nd edition of the International Classification of Primary Care and the 10th edition of the International Classification of Diseases, was obtained from clinical record linkage. To identify multimorbidity patterns, an exploratory factor analysis was conducted over chronic disease categories with a prevalence >5%, using Oblimin rotation and Kaiser's eigenvalues-greater-than-one rule. The association between multimorbidity patterns and their potential determinants was assessed with multivariable linear regression., Results: The three-factor solution (Musculoskeletal diseases and mental disorders, Cardiometabolic diseases, and Cardiopulmonary diseases) explained 64.5% of the total variance. Being older, lower occupational category, higher levels of loneliness, lower levels of physical activity, and higher body mass index were associated with higher scores in the multimorbidity patterns identified. Female sex was linked to the Musculoskeletal diseases and mental disorders pattern, while being male was revealed to the two remaining multimorbidity patterns. A high diet quality was inversely related to Cardiometabolic diseases, while optimal sleep duration was inversely related to Cardiopulmonary diseases., Conclusion: Three multimorbidity patterns were identified in older adults. Multimorbidity patterns were differently associated with social variables and lifestyles behavioral factors., (© 2023 S. Karger AG, Basel.)
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- 2023
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25. Glycemic variability and all-cause mortality in a large prospective southern European cohort of patients with differences in glycemic status.
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Salinero-Fort MA, San Andrés-Rebollo FJ, Cárdenas-Valladolid J, Mostaza JM, Lahoz C, Rodriguez-Artalejo F, Gómez-Campelo P, Vich-Pérez P, Jiménez-García R, López de Andrés A, and de Miguel-Yanes JM
- Subjects
- Blood Glucose, Cohort Studies, Female, Glycated Hemoglobin analysis, Humans, Male, Prospective Studies, Risk Factors, Diabetes Mellitus, Type 2, Prediabetic State
- Abstract
Background: Few studies have analyzed the relationship between glucose variability (GV) and adverse health outcomes in patients with differences in glycemic status. The present study tests the hypothesis that GV predicts all-cause mortality regardless of glycemic status after simple adjustment (age and sex) and full adjustment (age, sex, cardiovascular disease, hypertension, use of aspirin, statins, GLP-1 receptor agonists, SGLT-2 inhibitors and DPP-4 inhibitors, baseline FPG and average HbA1c)., Methods: Prospective cohort study with 795 normoglycemic patients, 233 patients with prediabetes, and 4,102 patients with type 2 diabetes. GV was measured using the coefficient of variation of fasting plasma glucose (CV-FPG) over 12 years of follow-up. The outcome measure was all-cause mortality., Results: A total of 1,223 patients (657 men, 566 women) died after a median of 9.8 years of follow-up, with an all-cause mortality rate of 23.35/1,000 person-years. In prediabetes or T2DM patients, the fourth quartile of CV-FPG exerted a significant effect on all-cause mortality after simple and full adjustment. A sensitivity analysis excluding participants who died during the first year of follow-up revealed the following results for the highest quartile in the fully adjusted model: overall, HR (95%CI) = 1.54 (1.26-1.89); dysglycemia (prediabetes and T2DM), HR = 1.41 (1.15-1.73); T2DM, HR = 1.36 (1.10-1.67)., Conclusion: We found CV-FPG to be useful for measurement of GV. It could also be used for the prognostic stratification of patients with dysglycemia., Competing Interests: The authors have declared that no competing interests exist.
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- 2022
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26. Use of statins and associated factors in nonagenarians in the Community of Madrid, Spain.
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Lahoz C, Cárdenas-Valladolid J, Salinero-Fort MÁ, and Mostaza JM
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- Aged, 80 and over, Cross-Sectional Studies, Female, Humans, Male, Nonagenarians, Spain epidemiology, Cardiovascular Diseases drug therapy, Cardiovascular Diseases epidemiology, Cardiovascular Diseases prevention & control, Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use
- Abstract
Background: The role of statins in the management of dyslipidemia in elderly patients with different cardiovascular risks remains unclear., Objective: To study use of statins and associated factors in subjects aged 90 or over in the Community of Madrid, Spain., Methods: Observational, cross-sectional study that included all people aged 90 or more residing in the Community of Madrid as of December 31, 2015. The clinical information was obtained from the database that contains the electronic medical records collected by family doctors in primary care. Comorbidity data are collected according to the International Classification of Primary Care, Second Edition (ICPC-2)., Results: The study population comprised 59,423 subjects, with a mean age of 93.3 (2.5) years (25.8% males). Slightly more than one quarter of the population (28.2%) was in treatment with statins, 21.9% were in primary prevention, and 48.1% in secondary prevention. The multivariate analysis revealed the factors independently associated with statin treatment to be younger age, not being institutionalized, a higher Barthel score, a lower Charlson score, a higher body mass index, and a history of diabetes, dyslipidemia, chronic kidney disease, and cardiovascular disease., Conclusions: A significant percentage of nonagenarians-mainly less frail patients with more comorbidities-in the Community of Madrid receive statin treatment. No clear efficacy has been demonstrated in reducing cardiovascular events in an age group with such a short life expectancy., (© 2021. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)
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- 2022
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27. Establishing Technical Values for Nursing Diagnoses in Primary Healthcare.
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Pérez-Rivas FJ, Martín-García Á, Sánz-Bayona MT, Fernández-Díaz MC, Barberá-Martín A, Cárdenas-Valladolid J, López-Palacios S, and Rico-Blázquez M
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- Adult, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Nursing Diagnosis, Primary Health Care
- Abstract
Purpose: To establish technical values for nursing diagnoses in primary healthcare with which to weight the delivery of care based on criteria of complexity and relevance., Methods: A three-phase cross-sectional descriptive study: (1) establishing and weighting of the assessment criteria of technical values, (2) scoring of the assessment criteria per diagnosis, and (3) assigning technical values., Findings: Diagnoses were ordered on the scoring scale obtained and a technical value of 1 to 4 was assigned according to their quartile., Conclusions: Having a technical value for each nursing diagnosis helps to measure the diversity and complexity of care., Implications for Nursing Practice: Technical values may contribute to improving nursing management indicators, as they incorporate a quantitative view into the assessment process., (© 2019 NANDA International, Inc.)
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- 2020
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28. Population-based cross-sectional study of 11 645 Spanish nonagenarians with type 2 diabetes mellitus: cardiovascular profile, cardiovascular preventive therapies, achievement goals and sex differences.
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Salinero-Fort MA, Mostaza-Prieto JM, Lahoz-Rallo C, Vicente Díez JI, and Cárdenas-Valladolid J
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- Aged, 80 and over, Cardiovascular Diseases epidemiology, Cardiovascular Diseases prevention & control, Cross-Sectional Studies, Diabetes Complications epidemiology, Diabetes Complications prevention & control, Female, Goals, Humans, Male, Risk Assessment, Sex Distribution, Sex Factors, Cardiovascular Diseases etiology, Diabetes Complications etiology, Diabetes Mellitus, Type 2 complications
- Abstract
Objectives: To evaluate the risk profile, achievement of cardiometabolic goals, and frequency and optimal use of cardiovascular preventive therapies among nonagenarians with type 2 diabetes mellitus (T2DM). To investigate possible sex differences., Design and Setting: A cross-sectional population study of 11 645 persons aged ≥90 years with T2DM living in Madrid (Spain). Sociodemographic, clinical and therapy profiles were collected through electronic records in primary care. We considered antihypertensive therapy and lipid-lowering therapy to be optimal when known patients with hypertension with albuminuria received renin-angiotensin system blockers and statins had been prescribed for overt cardiovascular disease., Results: The prevalence of coronary artery disease was higher in males than in females (21.5% vs 12.6%, p<0.01), as was that of peripheral artery disease (8.5% vs 2.3%, p<0.01). However, the prevalence of cerebrovascular disease was similar in both sexes (16.5% vs 16%; p=0.44). Haemoglobin A1c was lower than 7% in 64.4% of cases, with female predominance in patients with known dementia (67.1% female vs 59.9% male; p<0.01). Antiplatelet therapy was significantly more frequent in males than in females (48.1% vs 44.3%; p<0.01), as were statins (43.2% vs 40.2%; p<0.01). Both in primary and in secondary prevention, rates for simultaneous achievement of the HbA1c, blood pressure, LDL-C goals were significantly lower among females (p<0.01). For each criterion of optimal use of cardiovascular preventive therapies, adherence was significantly better in males than in females., Conclusion: Our study showed that the risk of cerebrovascular disease was similar in both male and female Spanish nonagenarians. Adherence was poorer in females for all criteria of optimal use of cardiovascular preventive therapies. Our findings indicate that the known sex differences in younger patients with T2DM persist in patients aged ≥90 years. There is considerable room for improvement in standards of preventive care in nonagenarians with T2DM, especially in females., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2019
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29. Prevalence of depression in patients with type 2 diabetes mellitus in Spain (the DIADEMA Study) : results from the MADIABETES cohort.
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Salinero-Fort MA, Gómez-Campelo P, San Andrés-Rebollo FJ, Cárdenas-Valladolid J, Abánades-Herranz JC, Carrillo de Santa Pau E, Chico-Moraleja RM, Beamud-Victoria D, de Miguel-Yanes JM, Jimenez-Garcia R, López-de-Andres A, Ramallo-Fariña Y, and De Burgos-Lunar C
- Subjects
- Aged, Aged, 80 and over, Depression psychology, Diabetes Mellitus, Type 2 drug therapy, Diabetes Mellitus, Type 2 psychology, Diabetic Nephropathies epidemiology, Female, Health Status, Humans, Incidence, Male, Mental Disorders epidemiology, Middle Aged, Prevalence, Prospective Studies, Protective Factors, Risk Factors, Sex Factors, Spain epidemiology, Depression epidemiology, Diabetes Mellitus, Type 2 epidemiology
- Abstract
Objective: To estimate the prevalence of depression in patients diagnosed with type 2 diabetes mellitus (T2DM), and to identify sociodemographic, clinical and psychological factors associated with depression in this population. Additionally, we examine the annual incidence rate of depression among patients with T2DM., Methods: We performed a large prospective cohort study of patients with T2DM from the Madrid Diabetes Study. The first recruitment drive included 3443 patients. The second recruitment drive included 727 new patients. Data have been collected since 2007 (baseline visit) and annually during the follow-up period (since 2008)., Results: Depression was prevalent in 20.03% of patients (n=592; 95% CI 18.6% to 21.5%) and was associated with previous personal history of depression (OR 6.482; 95% CI 5.138 to 8.178), mental health status below mean (OR 1.423; 95% CI 1.452 to 2.577), neuropathy (OR 1.951; 95% CI 1.423 to 2.674), fair or poor self-reported health status (OR 1.509; 95% CI 1.209 to 1.882), treatment with oral antidiabetic agents plus insulin (OR 1.802; 95% CI 1.364 to 2.380), female gender (OR 1.333; 95% CI 1.009 to 1.761) and blood cholesterol level (OR 1.005; 95% CI 1.002 to 1.009). The variables inversely associated with depression were: being in employment (OR 0.595; 95% CI 0.397 to 0.894), low physical activity (OR 0.552; 95% CI 0.408 to 0.746), systolic blood pressure (OR 0.982; 95% CI 0.971 to 0.992) and social support (OR 0.978; 95% CI 0.963 to 0.993). In patients without depression at baseline, the incidence of depression after 1 year of follow-up was 1.20% (95% CI 1.11% to 2.81%)., Conclusions: Depression is very prevalent among patients with T2DM and is associated with several key diabetes-related outcomes. Our results suggest that previous mental status, self-reported health status, gender and several diabetes-related complications are associated with differences in the degree of depression. These findings should alert practitioners to the importance of detecting depression in patients with T2DM., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2018
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30. Influenza vaccination in people with type 2 diabetes, coverage, predictors of uptake, and perceptions. Result of the MADIABETES cohort a 7years follow up study.
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Jiménez-Garcia R, Lopez-de-Andres A, Hernandez-Barrera V, Gómez-Campelo P, San Andrés-Rebollo FJ, de Burgos-Lunar C, Cárdenas-Valladolid J, Abánades-Herranz JC, and Salinero-Fort MA
- Subjects
- Adult, Aged, Aged, 80 and over, Female, Follow-Up Studies, Humans, Male, Middle Aged, Patient Acceptance of Health Care, Retrospective Studies, Diabetes Complications prevention & control, Diabetes Mellitus, Type 2 complications, Health Knowledge, Attitudes, Practice, Influenza Vaccines administration & dosage, Influenza, Human prevention & control, Vaccination psychology, Vaccination statistics & numerical data
- Abstract
Objectives: We aim to determine influenza vaccination uptake among people with diabetes included in the MADIABETES cohort study in order to identify predictors of uptake and to analyze reasons for adherence and non-adherence with vaccination., Methods: Using data from the MADIABETES Study we conducted a retrospective case record form based study without controls. We included outpatients with type 2 diabetes mellitus. Information was obtained from computerized clinical records and by telephone survey. The main dependent variables were influenza vaccination uptake in the year 2013 and the reason for receiving or refusing vaccination., Results: Overall, 65.7% had received the influenza vaccine in 2013. The mean number of influenza vaccines received from 2007 to 2013 was 3.24 (SD1.15), although 19.23% had not received any influenza vaccine and 23.3% had been vaccinated against pneumococcus. The variables that increased the probability of being vaccinated were inclusion in the age-based recommendation (⩾60years), having a chronic respiratory disease, previous pneumococcal vaccination, higher number of visits to the general practitioner, higher number of influenza vaccines, and longer time since diabetes diagnosis. A higher mean glycated haemoglobin value in 2013 was associated with a reduced probability of vaccination. Most patients (90%) agreed to be vaccinated following their physician's advice because of their age or their chronic conditions. The most common reason for refusal among men was the belief that they were not at risk (41.6% vs. 29.79% in women); the most common reason for refusal among women was fear of adverse reactions (32.53% vs. 20.23% in men)., Conclusions: The uptake of influenza vaccination among diabetic patients in the present study was below desirable levels. The main barrier to vaccination was lack of knowledge regarding the need for and risks and advantages of influenza vaccination. Healthcare professionals should educate and encourage influenza vaccination among people with diabetes., (Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.)
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- 2017
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31. Correction: Trends in the Prevalence of Depression in Hospitalized Patients with Type 2 Diabetes in Spain: Analysis of Hospital Discharge Data from 2001 to 2011.
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Lopez-de-Andrés A, Jiménez-Trujillo MI, Hernández-Barrera V, de Miguel-Yanes JM, Méndez-Bailón M, Perez-Farinos N, de Burgos Lunar C, Cárdenas-Valladolid J, Salinero-Fort MÁ, Jiménez-García R, and Carrasco-Garrido P
- Abstract
[This corrects the article DOI: 10.1371/journal.pone.0117346.].
- Published
- 2016
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32. Standardized nursing care plans in patients with type 2 diabetes mellitus: are they effective in the long-term?
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Cárdenas-Valladolid J, Salinero-Fort MA, Gómez-Campelo P, and López-Andrés A
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- Aged, Female, Follow-Up Studies, Humans, Male, Prospective Studies, Time Factors, Treatment Outcome, Diabetes Mellitus, Type 2 nursing, Patient Care Planning standards
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- 2015
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33. Trends in the prevalence of depression in hospitalized patients with type 2 diabetes in Spain: analysis of hospital discharge data from 2001 to 2011.
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Lopez-de-Andrés A, Jiménez-Trujillo MI, Hernández-Barrera V, de Miguel-Yanes JM, Méndez-Bailón M, Perez-Farinos N, de Burgos Lunar C, Cárdenas-Valladolid J, Salinero-Fort MÁ, Jiménez-García R, and Carrasco-Garrido P
- Subjects
- Aged, Aged, 80 and over, Database Management Systems, Depression etiology, Diabetes Mellitus, Type 2 complications, Female, Hospital Mortality trends, Hospitalization, Humans, Male, Middle Aged, Spain, Depression epidemiology, Diabetes Mellitus, Type 2 psychology
- Abstract
Background: This study aims to describe trends in the prevalence of depression among hospitalized patients with type 2 diabetes in Spain, 2001-2011., Methods: We selected patients with a discharge diagnosis of type 2 diabetes using national hospital discharge data. Discharges were grouped by depression status. Prevalence of depression globally and according to primary diagnoses based on the Charlson comorbidity index (CCI) were analyzed. We calculated length of stay (LOHS) and in-hospital mortality (IHM). Multivariate analysis was adjusted by age, year and comorbidity., Results: From 2001 to 2011, 4,723,338 discharges with type 2 diabetes were identified (4.93% with depression). Prevalence of depression in diabetic patients increased from 3.54% in 2001 to 5.80% in 2011 (p<0.05). The prevalence of depression was significantly higher in women than in men in each year studied and increased from 5.22% in 2001 to 9.24% in 2011 (p<0.01). The highest prevalence was observed in the youngest age group (35-59 years). The median LOHS decreased significantly over this period. Men with diabetes and depression had higher IHM than women in all the years studied (p<0.05). Older age and greater comorbidity were significantly associated with a higher risk of dying, among diabetic patients with concomitant depression., Conclusions: Prevalence of depression increased significantly among hospitalized diabetic patients from 2001 to 2011 even if the health profile and LOHS have improved over this period. Programs targeted at preventing depression among persons with diabetes should be reinforced in Spain.
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- 2015
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34. Trends in hypertension prevalence, awareness, treatment and control in an adult type 2 diabetes Spanish population between 2003 and 2009.
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de Burgos-Lunar C, Jiménez-García R, Salinero-Fort MA, Gómez-Campelo P, Gil A, Abánades-Herranz JC, Cárdenas-Valladolid J, and del Cura-González I
- Subjects
- Adult, Age Factors, Aged, Cross-Sectional Studies, Female, Health Knowledge, Attitudes, Practice, Humans, Hypertension etiology, Longitudinal Studies, Male, Middle Aged, Prevalence, Regression Analysis, Sex Factors, Spain epidemiology, Diabetes Mellitus, Type 2 complications, Diabetes Mellitus, Type 2 epidemiology, Hypertension drug therapy, Hypertension epidemiology
- Abstract
In patients with type 2 diabetes, the prevalence of hypertension is higher than in non-diabetic subjects. Despite the high cardiovascular risk involving hypertension in these patients, its prevalence and control are not well known. The aims of this study were: to estimate the hypertension prevalence, awareness, treatment and control in Spanish adults with type 2 diabetes attended in Primary Care; and to analyse its time trend from 2003 to 2009. A serial cross-sectional study from 2003 to 2009 was performed in 21 Primary Care Centres in Madrid. The study population comprised all patients with diagnosed type 2 diabetes in their computerised medical history. Overall annual prevalence during the period 2003-2009 was calculated from and according to sex and age groups. Linear trend tests, regression lines and coefficients of determination were used. In 2003 89.78% (CI 87.92-91.64) of patients with type 2 diabetes suffered hypertension and 94.76% (CI: 92.85-96.67) in 2009. This percentage was greater for women and for patients over 65 years old. 30% of patients suffered previously undiagnosed hypertension in 2003 and 23.1% in 2009. 97% of diagnosed patients received pharmacological treatment and 28.79% reached the blood pressure objective in 2009. The average number of antihypertensive drugs taken was 2.72 in 2003 and 3.27 in 2009. Only 5.2% of patients with type 2 diabetes show blood pressure levels below 130/80 mmHg. Although significant improvements have been achieved in the diagnosis and control of hypertension in people with type 2 diabetes, these continue to remain far from optimum.
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- 2014
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35. Effectiveness of standardized Nursing Care Plans in health outcomes in patients with type 2 Diabetes Mellitus: a two-year prospective follow-up study.
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Cárdenas-Valladolid J, Salinero-Fort MA, Gómez-Campelo P, de Burgos-Lunar C, Abánades-Herranz JC, Arnal-Selfa R, and Andrés AL
- Subjects
- Aged, Blood Pressure, Body Weight, Diabetes Mellitus, Type 2 complications, Diabetes Mellitus, Type 2 metabolism, Diabetes Mellitus, Type 2 physiopathology, Electronic Health Records, Female, Follow-Up Studies, Humans, Male, Prospective Studies, Reference Standards, Risk Factors, Diabetes Mellitus, Type 2 therapy, Outcome Assessment, Health Care statistics & numerical data, Patient Care Planning standards
- Abstract
Background: Implementation of a standardized language in Nursing Care Plans (SNCP) allows for increased efficiency in nursing data management. However, the potential relationship with patientś health outcomes remains uncertain. The aim of this study was to evaluate the effectiveness of SNCP implementation, based on North American Nursing Diagnosis Association (NANDA) and Nursing Interventions Classification (NIC), in the improvement of metabolic, weight, and blood pressure control of Type 2 Diabetes Mellitus (T2DM) patients., Methods: A two-year prospective follow-up study, in routine clinical practice conditions. 31 primary health care centers (Spain) participated with 24,124 T2DM outpatients. Data was collected from Computerized Clinical Records; SNCP were identified using NANDA and NIC taxonomies. Descriptive and ANCOVA analyses were conducted., Results: 18,320 patients were identified in the Usual Nursing Care (UNC) group and 5,168 in the SNCP group. At the two-year follow-up, the SNCP group improved all parameters except LDL cholesterol and diastolic blood pressure. We analyzed data adjustming by the baseline value for these variables and variables with statistically significant differences between groups at baseline visit. Results indicated a lowering of all parameters except HbA1c, but a statistically significant reduction was only observed with diastolic blood pressure results. However, the adjusted reduction of diastolic blood pressure is of little clinical relevance. Greater differences of control values for diastolic blood pressure, HbA1c, LDL-cholesterol and Body Mass Index were found in the SNCP group, but only reached statistical significance for HbA1c. A greater proportion of patients with baseline HbA1c ≥7 decreased to <7% at the two-year follow-up in the SNCP group than in the UNC group (16.9% vs. 15%; respectively; p = 0.01)., Conclusions: Utilization of SNCP was helpful in achieving glycemic control targets in poorly controlled patients with T2DM (HbA1c ≥7%). Diastolic blood pressure results were slightly improved in the SNCP group compared to the UNC group., Trial Registration: ClinicalTrials.gov NCT01482481.
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- 2012
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36. Validation of diabetes mellitus and hypertension diagnosis in computerized medical records in primary health care.
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de Burgos-Lunar C, Salinero-Fort MA, Cárdenas-Valladolid J, Soto-Díaz S, Fuentes-Rodríguez CY, Abánades-Herranz JC, and del Cura-González I
- Subjects
- Adult, Aged, Cross-Sectional Studies, Delayed Diagnosis, Diabetes Mellitus, Type 2 epidemiology, Diagnostic Errors, Female, Humans, Hypertension epidemiology, Male, Middle Aged, Prevalence, Sensitivity and Specificity, Spain epidemiology, Diabetes Mellitus, Type 2 diagnosis, Hypertension diagnosis, Medical Records Systems, Computerized, Primary Health Care
- Abstract
Background: Computerized Clinical Records, which are incorporated in primary health care practice, have great potential for research. In order to use this information, data quality and reliability must be assessed to prevent compromising the validity of the results.The aim of this study is to validate the diagnosis of hypertension and diabetes mellitus in the computerized clinical records of primary health care, taking the diagnosis criteria established in the most prominently used clinical guidelines as the gold standard against which what measure the sensitivity, specificity, and determine the predictive values.The gold standard for diabetes mellitus was the diagnostic criteria established in 2003 American Diabetes Association Consensus Statement for diabetic subjects. The gold standard for hypertension was the diagnostic criteria established in the Joint National Committee published in 2003., Methods: A cross-sectional multicentre validation study of diabetes mellitus and hypertension diagnoses in computerized clinical records of primary health care was carried out. Diagnostic criteria from the most prominently clinical practice guidelines were considered for standard reference.Sensitivity, specificity, positive and negative predictive values, and global agreement (with kappa index), were calculated. Results were shown overall and stratified by sex and age groups., Results: The agreement for diabetes mellitus with the reference standard as determined by the guideline was almost perfect (κ=0.990), with a sensitivity of 99.53%, a specificity of 99.49%, a positive predictive value of 91.23% and a negative predictive value of 99.98%.Hypertension diagnosis showed substantial agreement with the reference standard as determined by the guideline (κ=0.778), the sensitivity was 85.22%, the specificity 96.95%, the positive predictive value 85.24%, and the negative predictive value was 96.95%. Sensitivity results were worse in patients who also had diabetes and in those aged 70 years or over., Conclusions: Our results substantiate the validity of using diagnoses of diabetes and hypertension found within the computerized clinical records for epidemiologic studies.
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- 2011
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37. [Improving the continuous care process in primary care during weekends and holidays: redesigning and FMEA].
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Cañada Dorado A, Cárdenas Valladolid J, Espejo Matorrales F, García Ferradal I, Sastre Páez S, and Vicente Martín I
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- Continuity of Patient Care standards, Humans, Primary Health Care standards, Risk Management, Software, Spain, Continuity of Patient Care organization & administration, Primary Health Care organization & administration
- Abstract
Objective: To describe a project carried out in order to improve the process of Continuous Health Care (CHC) on Saturdays and bank holidays in Primary Care, area number 4, Madrid. The aim of this project was to guarantee a safe and error-free service to patients receiving home health care on weekends., Materials and Method: The urgent need for improving CHC process was identified by the Risk Management Functional Unit (RMFU) of the area. In addition, some complaints had been received from the nurses involved in the process as well as from their patients. A SWOT (Strengths, Weaknesses, Opportunities and Threats) analysis performed in 2009 highlighted a number of problems with the process. As a result, a project for improvement was drawn up, to be implemented in the following stages: 1. Redesigning and improving the existing process. 2. Application of failure mode and effect analysis (FMEA) to the new process. 3. Follow up, managing and leading the project. 4. Nurse training. 5. Implementing the process in the whole area. 6. CHC nurse satisfaction surveys., Results: After carrying out this project, the efficiency and level of automation improved considerably. Since implementation of the process enhancement measures, no complaints have been received from patients and surveys show that CHC nurse satisfaction has improved. By using FMEA, errors were given priority and enhancement steps were taken in order to: Inform professionals, back-up personnel and patients about the process. Improve the specialist follow-up report. Provide training in ulcer patient care., Conclusion: The process enhancement, and especially its automation, has resulted in a significant step forward toward achieving greater patient safety. FMEA was a useful tool, which helped in taking some important actions. Finally, CHC nurse satisfaction has clearly improved., (Copyright © 2009 SECA. Published by Elsevier Espana. All rights reserved.)
- Published
- 2010
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38. [Baseline risk of Diabetes Mellitus in Primary Health Care Services by FINDRISC test, associated factors and clinical outcome after 18 months of follow-up].
- Author
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Salinero-Fort MA, Carrillo-de Santa Pau E, Abánades-Herranz JC, Dujovne-Kohan I, and Cárdenas-Valladolid J
- Subjects
- Cross-Sectional Studies, Female, Follow-Up Studies, Humans, Incidence, Male, Middle Aged, Primary Health Care, Risk Assessment, Risk Factors, Surveys and Questionnaires, Time Factors, Diabetes Mellitus epidemiology
- Abstract
Objective: To estimate the risk of Diabetes Mellitus in Primary Health Care Services and diabetes incidence after 18 months of follow-up., Material and Methods: A multicenter study, with a first cross-sectional phase, to estimate the risk of Diabetes using the FINRISC test in 261 patients without Diabetes Mellitus treated in Primary Health Care Services. A second phase was carried out to assess Diabetes incidence after 18 months of follow-up., Results: 19.5% had an elevated risk of Diabetes Mellitus (FINDRISC score ≥15). The independent variables after adjusting for gender, which are not included in the FINDRISC test and were associated with increased risk of Diabetes, were low educational level and chronic ischemia of lower limbs. After 18 months of follow-up, 7.8% of patients with FINDRISC score ≥15 developed Diabetes versus 1.9% of patients with FINDRISC score <15., Conclusions: One out of five patients without Diabetes who are treated in Primary Care Health Services have a FINDRISC score ≥15, this being associated with low educational level and peripheral vascular disease, regardless of gender. The FINDRISC score ≥15 has a short-term association with a high risk of developing Diabetes Mellitus., (Copyright © 2009 Elsevier España, S.L. All rights reserved.)
- Published
- 2010
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39. [Implementation and improvement in a care program for the elderly on multiple medications in a primary care area].
- Author
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Cárdenas Valladolid J, Mena Mateo J, Cañada Dorado MM, Rodríguez Morales D, and Sánchez Perruca L
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- Aged, 80 and over, Government Programs statistics & numerical data, Health Personnel, Health Promotion organization & administration, Humans, Interdisciplinary Communication, Pharmacists, Program Evaluation, Quality of Life, Spain, Urban Population, Aged, Government Programs organization & administration, Polypharmacy, Primary Health Care organization & administration
- Abstract
Background: The purpose is to describe the introduction of a Care Program for the Elderly on Multiple Medication in a Primary Care area and the complete improvement cycle after evaluating the initial results The Program was instigated by the Community of Madrid Pharmacy Directorate., Methods: The Program was aimed at patients over 75 years who took 6 or more active ingredients (9721 patients in the area at the start of the program) and began in September 2006. It is based on coordinating with pharmacists, systematic review of treatment, health education, and the providing of personal dose dispensing systems for the correct use of the medication. Before its introduction, all the health professionals and pharmacists were jointly trained, a person was assigned as being responsible for the primary care teams (EAP) and support material was handed out. An initial evaluation was performed using computerised sentences from the Program data model in the electronic clinical notes, which showed much improvable results. Using quality tools, the causes of low coverage and insufficient results in the rest of the quality indicators were identified and corrective actions were introduced to subsequently monitor and re-assess the program., Results: Evaluation of the indicators included in the program. Initial data analysis (February 2007): cover, 3.5% (361 users included); treatment review (RT), 2.1%; review of medication use (RU), 51.2%; assessment of knowledge of the medication (CM), 84.8%; Morisky test (TM), 57.6%; offer of personal dispensing system (SPD), 57.1%; treatment evaluation (VT), 50.1%; care plans (PC), 19.2%; beers criteria (CB), 14.9%. After introducing the improvement actions, the following results were obtained in December 2007: cover, 131.8% (12,650 users); RT, 80.6%; RU, 62.7%; CM, 92.4%; TM, 9.3; SPD, 67.3%; VT, 61.6%; PC, 27.59%, and CB, 13.6%., Conclusions: The introduction of an institutional program, the involvement of the management of Area 4, the application of appropriate quality tools, the continuous monitoring of quality indicators and giving this information back to the professionals has enabled, ten months after the corrective measures were introduced, the institutional objectives of coverage to be achieved. It has also significantly improved quality care activities and their recording, achieving the best results for coverage and quality health care in the Community of Madrid program.
- Published
- 2009
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