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Students believe mathematics is best learned by memorization; however, endorsing memorization as a study strategy is associated with a decrease in learning (Schoenfeld, 1989). When the world changed with the onset of the COVID-19 global pandemic, instruction transitioned to fully remote instruction where many assignments and examinations became open textbook, open note, and even open Internet. In this new world, did students change their beliefs about the role of memorization in learning? Did academic performance change? And did the relationship between memorization beliefs and academic performance change? The current study takes advantage of data collected in an online interactive statistics textbook used by courses before (in-person) and after (remote) the declaration of the COVID-19 pandemic at three institutions, each representing a part of the California Master Plan for Higher Education (e.g., University of California, California State University, and California Community Colleges). Results from 2668 students who used the textbook showed that the UC institution had lower memorization belief scores compared to both the CSU and CCC institutions. Even when controlling for institution and chapter of the textbook, lower memorization belief scores were related to higher performance. Surprisingly, there were no significant differences in either memorization beliefs nor performance before and after transitioning to online remote instruction due to the pandemic. Although much of educational research is conducted in one institution, this kind of research can identify differences across institutional contexts to understand how learning can be affected by different teaching formats, including in-person and online/distance, brought on by disruptive social changes such as a global pandemic.

Great effort has been invested in increasing STEM achievement among students, but feelings of low status among underrepresented or otherwise vulnerable students may be creating additional challenges. The present study assessed how perceptions of social status within the classroom--termed subjective social status--aligned with objective course performance and differed by sex, first-generation status, work status, and race/ethnicity among 713 students enrolled across three introductory statistics classes. Findings indicated that final exam score was moderately related to ratings of subjective social status, suggesting that factors besides objective course performance may influence classroom subjective social status. When asked to explain how they evaluated their standing in the course, students reported five main themes, including both academic achievement with respect to exam scores and their understanding of course content. When examining differences by status-based identities in subjective social status, we found that female and first-generation students had lower subjective social status compared to their male and continuing-generation peers, although results were less robust for first-generation status. Likewise, working students reported lower subjective social status relative to non-working students, despite showing no difference in final exam score. In contrast, although Asian/Asian American students outperformed Latine students, there were no differences in reports of subjective social status between Asian/Asian American, Latine, and white students. Taken together, results suggest that factors beyond course performance may relate to students' subjective social status, and subjective social status may contribute to disparities in academic performance, especially by sex and work status. [Page range listed on publisher's website incorrect, correct page range is p1921-1946.]

Abstract Dementia and cancer are multifactorial, widely-feared, age-associated clinical syndromes that are increasing in prevalence. There have been major breakthroughs in clinical cancer research leading to some effective treatments, whereas the field of dementia has achieved comparatively limited success in clinical research. The lessons of cancer research may help those in the dementia research field in confronting some of the dilemmas faced when the clinical care regimen is not entirely safe or efficacious. Cancer clinical trials have assumed that untreated individuals with cancer are at high risk for morbidity and mortality after primary diagnoses. Thus, patients deserve a choice of clinical interventions, either standard of care or experimental, even if the benefits are not certain and the therapy’s side effects are potentially severe. The prognosis for many individuals at risk for dementia carries a correspondingly high level of risk for both mortality and severe morbidity, particularly if one focuses on “health-span” rather than lifespan. Caregivers and patients can be strongly impacted by dementia and the many troubling associated symptoms that often go well beyond amnesia. Polls, surveys, and a literature on “dementia worry” strongly underscore that the public fears dementia. While there are institutional and industry hurdles that complicate enrollment in randomized trials, the gravity of the future morbidity and mortality inherent in a dementia diagnosis may require reconsideration of the current protective stance that limits the freedom of at-risk individuals (either symptomatic or asymptomatic) to participate and potentially benefit from ongoing clinical research. There is also evidence from both cancer and dementia research that individuals enrolled in the placebo arms of clinical trials have unexpectedly good outcomes, indicating that participation in clinical trial can have medical benefits to enrollees. To highlight aspects of cancer clinical research that may inform present and future dementia clinical research, this review highlights three main themes: the risk of side effects should be weighed against the often dire consequences of non-treatment; the desirability of long-term incremental (rather than “magic bullet”) clinical advances; and, the eventual importance of combination therapies, reflecting that the dementia clinical syndrome has many underlying biological pathways.

People with developmental disabilities (DD) lack access to many aspects of sexuality education and often experience restrictions in romantic relationships. One factor contributing to this lack of access includes parents feeling uncomfortable providing appropriate sexuality education to their children with DD despite being the primary source of this information. To better understand what supports are available to parents, the current thematic review explored the existing literature on sexuality education for individuals with DD that explicitly includes parent involvement. Resulting literature was thematically clustered into four categories (a) parent opinion on curriculum/program content or delivery; (b) parent participation as a training recipient; (c) parent feedback and post-implementation outcomes, and (d) recommendations from program developers on how to better utilize parents. Current literature highlights how parents can have a meaningful role in the development of sexuality programs, and how individuals with DD can greatly benefit from programs that include parent involvement.

Using data from the first flight of Spider and from the Planck High Frequency Instrument, we probe the properties of polarized emission from interstellar dust in the Spider observing region. Component-separation algorithms operating in both the spatial and harmonic domains are applied to probe their consistency and to quantify modeling errors associated with their assumptions. Analyses of diffuse Galactic dust emission spanning the full Spider region demonstrate (i) a spectral energy distribution that is broadly consistent with a modified-blackbody (MBB) model with a spectral index of β _d = 1.45 ± 0.05 (1.47 ± 0.06) for E ( B )-mode polarization, slightly lower than that reported by Planck for the full sky; (ii) an angular power spectrum broadly consistent with a power law; and (iii) no significant detection of line-of-sight polarization decorrelation. Tests of several modeling uncertainties find only a modest impact (∼10% in σ _r ) on Spider ’s sensitivity to the cosmological tensor-to-scalar ratio. The size of the Spider region further allows for a statistically meaningful analysis of the variation in foreground properties within it. Assuming a fixed dust temperature T _d = 19.6 K, an analysis of two independent subregions of that field results in inferred values of β _d = 1.52 ± 0.06 and β _d = 1.09 ± 0.09, which are inconsistent at the 3.9 σ level. Furthermore, a joint analysis of Spider and Planck 217 and 353 GHz data within one subregion is inconsistent with a simple MBB at more than 3 σ , assuming a common morphology of polarized dust emission over the full range of frequencies. This evidence of variation may inform the component-separation approaches of future cosmic microwave background polarization experiments.

Abstract Introduction The advent of disease‐modifying therapies for Alzheimer's disease (AD) has raised many questions and debates in the field as to the clinical benefits, risks, and costs of such therapies. The controversies have resulted in the perception that many clinicians are apprehensive about prescribing these medications to their patient populations. There also remains widespread uncertainty as to the economic impact, cost benefit ratio, and safety oversight for use of these medications in standard clinical care settings. Methods To contextualize such issues, the present study compared anti‐amyloid biologic therapy (lecanemab) to four commonly used biologic agents in other fields, including trastuzumab for breast cancer, bevacizumab for lung cancer, etanercept for rheumatoid arthritis, and ocrelizumab for multiple sclerosis. Results The data presented demonstrate comparable costs, clinical benefits, and risks for these biologic agents in their disparate disease states. Discussion These results provide context for the costs, clinical benefits, and safety regarding the mainstream use of anti‐amyloid biologic agents for the prevention of cognitive loss. While the era of disease‐modifying therapies for AD is now in its infancy, there is an expectation that these discoveries will be followed by improved therapies and combination treatments leading to greater efficacy in ameliorating the clinical trajectory of AD. Highlights Anti‐amyloid therapy costs are comparable to other commonly used biologics. Anti‐amyloid therapy efficacy is comparable to other commonly used biologics. Anti‐amyloid therapy safety is compatible with other commonly used biologics.

Abstract Monitoring real-world battery degradation is crucial for the widespread application of batteries in different scenarios. However, acquiring quantitative degradation information in operating commercial cells is challenging due to the complex, embedded, and/or qualitative nature of most existing sensing techniques. This process is essentially limited by the type of signals used for detection. Here, we report the use of effective battery thermal conductivity (k eff ) as a quantitative indicator of battery degradation by leveraging the strong dependence of k eff on battery-structure changes. A measurement scheme based on attachable thermal-wave sensors is developed for non-embedded detection and quantitative assessment. A proof-of-concept study of battery degradation during fast charging demonstrates that the amount of lithium plating and electrolyte consumption associated with the side reactions on the graphite anode and deposited lithium can be quantitatively distinguished using our method. Therefore, this work opens the door to the quantitative evaluation of battery degradation using simple non-embedded thermal-wave sensors.

Understanding the composition of disposed municipal solid waste (MSW) and recyclables can lead to better waste management. New York State (United States) has never had a state-wide waste characterization sorting program. In 2021, sampling was conducted at 11 locations, representing 25% of the state population outside of New York City. Twenty-three tonnes from 173 discrete samples were sorted into 41 categories. The resulting data were analyzed by single constituent approaches and more novel multivariate distance techniques. The analyses found that disposed MSW was 22.8% paper, 20.5% food, and 16.8% plastics. Recyclable paper and glass–metal–plastic containers were 18.2% (11.7% paper, 6.5% containers) and yard waste was 6.5%, meaning about 25% of the disposed MSW could have been recovered. Multivariate analysis determined that the disposed MSW was similar to that from other United States jurisdictions such as Wisconsin, Pennsylvania, New York City, and Syracuse (NY), and different from California and United States Environmental Protection Agency model data. Recyclables composition was different from disposed MSW composition. Dual-stream recyclables were sorted better than single-stream recyclables. Corrugated cardboard was the most common paper recyclable and plastics were the most common container recyclable. The data are being used to help guide planning for an expected packaging extended producer responsibility law for the State.

Abstract The mass adoption of electric vehicles is hindered by the inadequate extreme fast charging (XFC) performance (i.e., less than 15 min charging time to reach 80% state of charge) of commercial high-specific-energy (i.e., >200 Wh/kg) lithium-ion batteries (LIBs). Here, to enable the XFC of commercial LIBs, we propose the regulation of the battery’s self-generated heat via active thermal switching. We demonstrate that retaining the heat during XFC with the switch OFF boosts the cell’s kinetics while dissipating the heat after XFC with the switch ON reduces detrimental reactions in the battery. Without modifying cell materials or structures, the proposed XFC approach enables reliable battery operation by applying

ABSTRACTThe COVID-19 pandemic and shift to remote instruction disrupted students’ learning and well-being. This study explored undergraduates’ incoming course concerns and later perceived challenges in an introductory statistics course. We explored how the frequency of concerns changed with the onset of COVID-19 ([Formula: see text]1417) and, during COVID-19, how incoming concerns compared to later perceived challenges ([Formula: see text]524). Students were most concerned about R coding, understanding concepts, workload, prior knowledge, time management, and performance, with each of these concerns mentioned less frequently during than before COVID-19. Concerns most directly related to the pandemic—virtual learning and inaccessibility of resources—showed an increase in frequency. The frequency of concerns differed by gender and URM status. The most frequently mentioned challenges were course workload, virtual learning, R coding, and understanding concepts, with significant differences by URM status. Concerns about understanding concepts, lack of prior knowledge, performance, and time management declined from the beginning to the end of the term. Workload had the highest rate of both consistency and emergence across the term. Because students’ perceptions have an impact on their experiences and expectations, understanding and addressing concerns and challenges could help guide instructional designers and policymakers as they develop interventions.

Abstract Background and Aim This study evaluates whether a stool donor program to supply fecal microbiota transplantation (FMT) product is feasible in the Australian regulatory environment. The primary outcome was capacity to supply FMT product. The secondary outcomes were donor eligibility, retention, and output. Methods Prospective observational cohort study using data collected from the stool donor and FMT production records from BiomeBank, South Australia. Participants were people who engaged with BiomeBank's donor screening and FMT manufacturing process between 01 January 2021 and 31 December 2021. Results In total 176 people registered interest in the program, 74 of 176 (42.0%) proceeded to written questionnaire, 14 of 176 (8.0%) underwent clinical assessment, and 8 of 176 (4.5%) enrolled in the program. Two people were ineligible based on laboratory tests: both had an extended spectrum beta‐lactamase producing organism in stool and one also tested positive for hepatitis B core antibody. Two donors remained eligible from 2020, resulting in 10 enrolled donors in 2021; 5 of 10 (50%) male with a median age of 36.9 years (interquartile range, 30.3–42.7 years). All donors were ineligible to donate at some time point. There were 144 stool donations processed into 1480 50 mL FMT; 413 FMT were shipped to 33 Australian hospitals for treatment, 470 for clinical trials, and 89 were destroyed prior to release from quarantine. Conclusion Recruitment into the program, retention, and maximizing the yield from a donation period was challenging. Despite this, BiomeBank was able to produce and supply FMT to Australian hospitals under the TGA‐regulated Class 2 Biologicals framework.

We developed an interactive online textbook that interleaves R programming activities with text as a way to facilitate students’ understanding of statistical ideas while minimizing the cognitive and emotional burden of learning programming. In this exploratory study, we characterize the attitudes and experiences of 672 undergraduate students as they used our online textbook as part of a 10-week introductory course in statistics. Students expressed negative attitudes and concerns related to R at the beginning of the course, but most developed more positive attitudes after engaging with course materials, regardless of demographic characteristics or prior programming experience. Analysis of a subgroup of students revealed that change in attitudes toward R may be linked to students’ patterns of engagement over time and students’ perceptions of the learning environment.

We present a flare star catalog from 4 yr of nontargeted millimeter-wave survey data from the South Pole Telescope (SPT). The data were taken with the SPT-3G camera and cover a 1500 deg ^2 region of the sky from 20 ^h 40 ^m 0 ^s to 3 ^h 20 ^m 0 ^s in right ascension and from −42° to −70° in declination. This region was observed on a nearly daily cadence from 2019 to 2022 and chosen to avoid the plane of the galaxy. A short-duration transient search of this survey yields 111 flaring events from 66 stars, increasing the number of both flaring events and detected flare stars by an order of magnitude from the previous SPT-3G data release. We provide cross-matching to Gaia DR3, as well as matches to X-ray point sources found in the second ROSAT all-sky survey. We have detected flaring stars across the main sequence, from early-type A stars to M dwarfs, as well as a large population of evolved stars. These stars are mostly nearby, spanning 10–1000 pc in distance. Most of the flare spectral indices are constant or gently rising as a function of frequency at 95/150/220 GHz. The timescale of these events can range from minutes to hours, and the peak ν L _ν luminosities range from 10 ^27 to 10 ^31 erg s ^−1 in the SPT-3G frequency bands.

We forecast constraints on cosmological parameters enabled by three surveys conducted with SPT-3G, the third-generation camera on the South Pole Telescope. The surveys cover separate regions of 1500, 2650, and 6000 deg ^2 to different depths, in total observing 25% of the sky. These regions will be measured to white noise levels of roughly 2.5, 9, and $12\ \mu {\rm{K}}$ -armin, respectively, in cosmic microwave background (CMB) temperature units at 150 GHz by the end of 2024. The survey also includes measurements at 95 and 220 GHz, which have noise levels a factor of ∼1.2 and 3.5 times higher than 150 GHz, respectively, with each band having a polarization noise level $\sim \sqrt{2}$ times higher than the temperature noise. We use a novel approach to obtain the covariance matrices for jointly and optimally estimated gravitational lensing potential band powers and unlensed CMB temperature and polarization band powers. We demonstrate the ability to test the ΛCDM model via the consistency of cosmological parameters constrained independently from SPT-3G and Planck data, and consider the improvement in constraints on ΛCDM extension parameters from a joint analysis of SPT-3G and Planck data. The ΛCDM cosmological parameters are typically constrained with uncertainties up to ∼2 times smaller with SPT-3G data, compared to Planck, with the two data sets measuring significantly different angular scales and polarization levels, providing additional tests of the standard cosmological model.

Abstract Background This study profiles ceramides extracted from visceral and subcutaneous adipose tissue of human subjects by liquid chromatography‐mass spectrometry to determine a correlation with status of diabetes and gender. Methods Samples of visceral and abdominal wall subcutaneous adipose tissue (n = 36 and n = 31, respectively) were taken during laparoscopic surgery from 36 patients (14 nondiabetic, 22 diabetic and prediabetic) undergoing bariatric surgery with a body mass index (BMI) >35 kg/m2 with ≥1 existing comorbidity or BMI ≥40 kg/m2. Sphingolipids were extracted and analyzed using liquid chromatography‐mass spectrometry. Results After logarithm 2 conversion, paired analysis of visceral to subcutaneous tissue showed differential accumulation of Cer(d18:1/16:0), Cer(d18:1/18:0), and Cer(d18:1/24:1) in visceral tissue of prediabetic/diabetic female subjects, but not in males. Within‐tissue analysis showed higher mean levels of ceramide species linked to insulin resistance, such as Cer(d18:1/18:0) and Cer(d18:1/16:0), in visceral tissue of prediabetic/diabetic patients compared with nondiabetic subjects and higher content of Cer(d18:1/14:0) in subcutaneous tissue of insulin‐resistant female patients compared with prediabetic/diabetic males. Statistically significant differences in mean levels of ceramide species between insulin‐resistant African American and insulin‐resistant Caucasian patients were not evident in visceral or subcutaneous tissue. Conclusions Analysis of ceramides is important for developing a better understanding of biological processes underlying type 2 diabetes, metabolic syndrome, and obesity. Knowledge of the accumulated ceramides/dihydroceramides may reflect on the prelipolytic state that leads the lipotoxic phase of insulin resistance and may shed light on the predisposition to insulin resistance by gender.

A small percentage of bladder cancers in the general population have been found to harbor DNA viruses. In contrast, up to 25% of tumors of solid organ transplant recipients, who are at an increased risk of developing bladder cancer and have an overall poorer outcomes, harbor BK polyomavirus (BKPyV). To better understand the biology of the tumors and the mechanisms of carcinogenesis from potential oncoviruses, we performed whole genome and transcriptome sequencing on bladder cancer specimens from 43 transplant patients. Nearly half of the tumors from this patient population contained viral sequences. The most common were from BKPyV (N=9, 21%), JC polyomavirus (N=7, 16%), carcinogenic human papillomaviruses (N=3, 7%), and torque teno viruses (N=5, 12%). Immunohistochemistry revealed variable Large T antigen expression in BKPyV-positive tumors ranging from 100% positive staining of tumor tissue to less than 1%. In most cases of BKPyV-positive tumors, the viral genome appeared to be clonally integrated into the host chromosome consistent with microhomology-mediated end joining and coincided with focal amplifications of the tumor genome similar to other virus-mediated cancers. Significant changes in host gene expression consistent with the functions of BKPyV Large T antigen were also observed in these tumors. Lastly, we identified four mutation signatures in our cases, with those attributable to APOBEC3 and SBS5 being the most abundant. Mutation signatures associated with an antiviral drug, ganciclovir, and aristolochic acid, a nephrotoxic compound found in some herbal medicines, were also observed. The results suggest multiple pathways to carcinogenesis in solid organ transplant recipients with a large fraction being virus-associated.

Including millimeter-wave data in multiwavelength studies of the variability of active galactic nuclei (AGN) can provide insights into AGN physics that are not easily accessible at other wavelengths. We demonstrate in this work the potential of cosmic microwave background (CMB) telescopes to provide long-term, high-cadence millimeter-wave AGN monitoring over large fractions of sky. We report on a pilot study using data from the SPTpol instrument on the South Pole Telescope (SPT), which was designed to observe the CMB at arcminute and larger angular scales. Between 2013 and 2016, SPTpol was used primarily to observe a single 500 deg ^2 field, covering the entire field several times per day with detectors sensitive to radiation in bands centered at 95 and 150 GHz. We use SPT 150 GHz observations to create AGN light curves, and we compare these millimeter-wave light curves to those at other wavelengths, in particular γ -ray and optical. In this Letter, we focus on a single source, PKS 2326-502, which has extensive, day-timescale monitoring data in gamma-ray, optical, and now millimeter-wave between 2013 and 2016. We find PKS 2326-502 to be in a flaring state in the first 2 yr of this monitoring, and we present a search for evidence of correlated variability between millimeter-wave, optical R- band, and γ -ray observations. This pilot study is paving the way for AGN monitoring with current and upcoming CMB experiments such as SPT-3G, Simons Observatory, and CMB-S4, including multiwavelength studies with facilities such as Vera C. Rubin Observatories Large Synoptic Survey Telescope.

In this study, we examined the effect of video-based feedback designed to highlight a peer engaging in effective thinking processes on self-efficacy beliefs and learning outcomes (performance on a delayed quiz). Students in an introductory statistics course participated in an online learning activity where they received feedback in one of three randomly assigned conditions: a video of a peer demonstrating the process of arriving at a correct answer (mastery condition), a peer making mistakes then self-correcting those errors before arriving at a correct answer (coping condition), or a screenshot of a peer’s correct worked example (as a control). Results indicated that students who watched the mastery videos, but not the coping videos, rated their self-efficacy higher and scored higher on a class quiz taken more than a day after the feedback intervention than students who viewed a worked example. However, students in the two video conditions did not significantly differ in terms of either self-efficacy and quiz performance. The results of this study, although modest in scope, illustrate how the design of feedback could lead to noticeable differences in student learning.

Abstract Background and Aim Fecal microbiota transplantation (FMT) is a highly effective therapy for recurrent or refractory Clostridioides difficile infection (rCDI). Despite inclusion in society guidelines, the uptake of FMT therapy has been variable. Physician and patient attitudes may be a barrier to evidence‐based uptake of therapies; however, data assessing attitudes regarding FMT for rCDI are limited. Methods The South Australian FMT for CDI database prospectively recorded patient outcomes of FMT for CDI from August 2013 to January 2019. A total of 93 consecutive patients who underwent FMT for rCDI in South Australia were invited to participate in a 20‐question survey regarding the patient experience of FMT. All gastroenterologists and infectious disease physicians practicing in South Australia were invited to participate in an online survey comprised of 22 questions that addressed referral experience, indications for referral, perceived risks, and regulation and funding. Results Fifty‐four patients (54/93, 58%) returned the survey, of whom 52 (96%) would recommend FMT to others, and 51 (94%) were satisfied with treatment outcome. Fifty physicians returned the online survey (50/100, 50%), of whom 23 (46%) were concerned about disease transmission risk, and 15 (30%) believed that the risk of FMT would outweigh the benefit. Infectious diseases physicians and advanced trainees had significantly greater concern regarding the potential alteration of the microbiome than gastroenterology physicians and advanced trainees (8/17 (47%) vs 6/33 (18%); P = 0.047). Conclusion Despite high levels of patient‐reported satisfaction following FMT, physician‐reported reservations exist and may present a barrier to uptake of this therapy.

Capparis kbangensis Sy & D.V. Hai, a new species from Kbang District, Gia Lai Province, Vietnam, is described and illustrated. The new species is morphologically similar to Capparis versicolor but differs by several characters such as emarginate leaf apex, hairy margin of sepals, smaller fruits, and fewer seeds per fruit. Its ecology and conservation status are provided along with a taxonomic key to the closely allied species.

Abstract Given that adverse remodeling is the leading cause of heart failure and death in the USA, there is an urgent unmet need to develop new methods in dealing with this devastating disease. Here we evaluated the efficacy of a short-course glucagon-like peptide-1 receptor agonist therapy—specifically 2-quinoxalinamine, 6,7-dichloro-N-(1,1-dimethylethyl)-3-(methylsulfonyl)-,6,7-dichloro-2-methylsulfonyl-3-N-tert-butylaminoquinoxaline (DMB; aka Compound 2) – in attenuating adverse LV remodeling. We also examined the role, if any, of mitochondrial turnover in this process. Wild-type, Parkin knockout and MitoTimer-expressing mice were subjected to permanent coronary artery ligation, then treated briefly with DMB. LV remodeling and cardiac function were assessed by histology and echocardiography. Autophagy and mitophagy markers were examined by western blot and mitochondrial biogenesis was inferred from MitoTimer protein fluorescence and qPCR. We found that DMB given post-infarction significantly reduced adverse LV remodeling and the decline of cardiac function. This paralleled an increase in autophagy, mitophagy and mitochondrial biogenesis. The salutary effects of the drug were lost in Parkin knockout mice, implicating Parkin-mediated mitophagy as part of its mechanism of action. Our findings suggest that enhancing Parkin-associated mitophagy and mitochondrial biogenesis after infarction is a viable target for therapeutic mitigation of adverse remodeling.

This procedure describes the setup and testing protocol for metal-supported solid oxide electrolysis cell (MS-SOEC) button cell performance evaluation. It defines a standard testing protocol, describes materials selection, and identifies common pitfalls for testing MS-SOEC button cells.

We characterize Galactic dust filaments by correlating BICEP/Keck and Planck data with polarization templates based on neutral hydrogen (H i ) observations. Dust polarization is important for both our understanding of astrophysical processes in the interstellar medium (ISM) and the search for primordial gravitational waves in the cosmic microwave background (CMB). In the diffuse ISM, H i is strongly correlated with the dust and partly organized into filaments that are aligned with the local magnetic field. We analyze the deep BICEP/Keck data at 95, 150, and 220 GHz, over the low-column-density region of sky where BICEP/Keck has set the best limits on primordial gravitational waves. We separate the H i emission into distinct velocity components and detect dust polarization correlated with the local Galactic H i but not with the H i associated with Magellanic Stream i . We present a robust, multifrequency detection of polarized dust emission correlated with the filamentary H i morphology template down to 95 GHz. For assessing its utility for foreground cleaning, we report that the H i morphology template correlates in B modes at a ∼10%–65% level over the multipole range 20 < ℓ < 200 with the BICEP/Keck maps, which contain contributions from dust, CMB, and noise components. We measure the spectral index of the filamentary dust component spectral energy distribution to be β = 1.54 ± 0.13. We find no evidence for decorrelation in this region between the filaments and the rest of the dust field or from the inclusion of dust associated with the intermediate velocity H i . Finally, we explore the morphological parameter space in the H i -based filamentary model.

We present estimates of line-of-sight distortion fields derived from the 95 and 150 GHz data taken by BICEP2, BICEP3, and the Keck Array up to the 2018 observing season, leading to cosmological constraints and a study of instrumental and astrophysical systematics. Cosmological constraints are derived from three of the distortion fields concerning gravitational lensing from large-scale structure, polarization rotation from magnetic fields or an axion-like field, and the screening effect of patchy reionization. We measure an amplitude of the lensing power spectrum ${A}_{L}^{\phi \phi }=0.95\pm 0.20$ . We constrain polarization rotation, expressed as the coupling constant of a Chern–Simons electromagnetic term g _a _γ ≤ 2.6 × 10 ^−2 / H _I , where H _I is the inflationary Hubble parameter, and an amplitude of primordial magnetic fields smoothed over 1 Mpc B _1Mpc ≤ 6.6 nG at 95 GHz. We constrain the rms of optical depth fluctuations in a simple “crinkly surface” model of patchy reionization, finding A ^τ < 0.19 (2 σ ) for the coherence scale of L _c = 100. We show that all of the distortion fields of the 95 and 150 GHz polarization maps are consistent with simulations including lensed ΛCDM, dust, and noise, with no evidence for instrumental systematics. In some cases, the EB and TB quadratic estimators presented here are more sensitive than our previous map-based null tests at identifying and rejecting spurious B -modes that might arise from instrumental effects. Finally, we verify that the standard deprojection filtering in the BICEP/Keck data processing is effective at removing temperature to polarization leakage.

The availability of automatic data analysis tools and large databases have enabled new ways of studying language and communication that were not possible in the pre-information era. Here we apply a quantitative analysis to a large dataset of USA congressional speeches made over a period of 138 years. The analysis reveals that the readability index of congressional speeches increased consistently until the 96th congress, and then started to decline. Congressional speeches have also become more positive over time, and in general express more sentiments compared to speeches made in the 19th century or early 20th century. The analysis also shows statistically significant differences between Democratic and Republican congressional speeches.

Hospitalization is common among older adults. Prolonged time in bed during hospitalization can lead to deconditioning and functional impairments. Our team is currently working with Department of Veterans Affairs (VA) medical centers across the United States to implement STRIDE (assiSTed eaRly mobIlity for hospitalizeD older vEterans), a hospital-based walking program designed to mitigate the risks of immobility during hospitalization. However, the COVID-19 pandemic made in-person, or face-to-face, walking challenging due to social distancing recommendations and infection control concerns. In response, our team applied principles of implementation science, including stakeholder engagement, prototype development and refinement, and rapid dissemination and feedback, to create STRIDE in Your Room (SiYR). Consisting of self-guided exercises, light exercise equipment (e.g., TheraBands, stress ball, foam blocks, pedometer), the SiYR program provided safe alternative activities when face-to-face walking was not available during the pandemic. We describe the methods used in developing the SiYR program; present feedback from participating sites; and share initial implementation experiences, lessons learned, and future directions.