268 results on '"C, Massone"'
Search Results
2. Consensus on the place in therapy of biologics in the treatment of patients with chronic plaque psoriasis
- Author
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Andrea Francesco Pestarino, M. Baldari, Martina Burlando, Aurora Parodi, G Cannata, C. Massone, Alexandra M G Brunasso Vernetti, and Daniela Stradini
- Subjects
Plaque psoriasis ,medicine.medical_specialty ,Biological Products ,Infectious Diseases ,Text mining ,Consensus ,business.industry ,Medicine ,Humans ,Psoriasis ,Dermatology ,business - Published
- 2021
3. An expert consensus report on Mycosis fungoides in Italy: epidemiological impact and diagnostic-therapeutic pathway
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Francesco Onida, C. Massone, Mauro Alaibac, Nicola Pimpinelli, Marco Ardigò, Emilio Berti, Iris Zalaudek, Nicola di Meo, Pietro Quaglino, Gabriele Simontacchi, Antonello Baldo, Silvia Alberti Violetti, Alberti Violetti, Silvia, Alaibac, Mauro, Ardigò, Marco, Baldo, Antonello, DI Meo, Nicola, Massone, Cesare, Onida, Francesco, Simontacchi, Gabriele, Zalaudek, Iri, Pimpinelli, Nicola, Quaglino, Pietro, and Berti, Emilio
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medicine.medical_specialty ,Consensus ,Skin Neoplasms ,Lymphoma ,MEDLINE ,Dermatology ,Disease ,Guideline ,Cutaneous lymphoma ,Mycosis Fungoides ,Epidemiology ,medicine ,Humans ,Stage (cooking) ,Intensive care medicine ,Mycosis fungoides ,business.industry ,Incidence (epidemiology) ,medicine.disease ,T-Cell ,Italy ,Lymphoma, T-Cell, Cutaneous ,Treatment ,Infectious Diseases ,Cutaneous ,business - Abstract
Mycosis fungoides (MF) is a rare neoplasm representing the most frequent form of primary cutaneous T-cell lymphoma (CTCL). Diagnosis of MF is generally complex, often requiring integration of clinical, histological, immunophenotypic and molecular data. Currently, there are no epidemiological data supported by registries or local studies on MF in Italy. Moreover, the clinical management of MF in Italy is heterogeneous, and differs according to the geographical area and experience of the physician who manages the disease. Considering the uncertainties in the current scenario for MF in Italy, a consensus project involving experts on CTCL was initiated to define the epidemiological impact of MF and obtain information about the current diagnostic and therapeutic pathway of this disease in Italy. The prevalence of MF in Italy was estimated to be 6,800 patients, 4,900 of whom with early stage of disease; the estimated incidence ranged between 270 and 330 new cases per year. Among the clinical figures involved in the multidisciplinary management of MF, dermatologists were recognised as a reference point for both diagnosis and therapeutic decisions. These findings suggest the importance of monitoring both the disease and its management; it is, therefore, interesting to set up regional registries for monitoring and recognition of rare tumor status for MF. The results further indicate the need to train physicians to favour more rapid diagnosis and simplify the pathway for referring patients to reference centres with adequate diagnostic and treatment standards. In light of the forthcoming introduction of new therapies, the development of a nationwide PDTA (Path of Diagnostic Therapeutic Care, in Italian defined as Percorso Diagnostico-Terapeutico Assistenziale) is also of substantial importance.
- Published
- 2021
4. Leprosy patients in the Emergency Department
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Paolo Cremonesi, Patrizia Forgione, C. Massone, and Gianfranco Barabino
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business.industry ,Medicine ,Emergency department ,Medical emergency ,Leprosy ,business ,medicine.disease - Published
- 2021
5. Psoriasis and palmoplantar pustulosis: an endless debate?
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A.M.G. Brunasso and C. Massone
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medicine.medical_specialty ,Palmoplantar pustulosis ,business.industry ,Dermatology ,medicine.disease ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Infectious Diseases ,Psoriasis ,medicine ,Humans ,030212 general & internal medicine ,business - Published
- 2017
6. Acantosis Nigricans Maligna Acanthosis Nigricans Maligna
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C Vallejo, G Castillo, A Martorano, C Massone, and C Villanueva
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Acantosis nigricans maligna ,Adenocarcinoma gástrico ,Malignant acanthosis nigricans ,Gastric adenocarcinoma ,Medicine ,Dermatology ,RL1-803 - Abstract
Es un síndrome paraneoplásico poco común, que se asocia a tumores gastrointestinales, más frecuentemente a adenocarcinoma gástrico (69%). Afecta a ambos sexos y no tiene prevalencia por grupo étnico alguno. Clínicamente son lesiones hiperpigmentadas, hipertróficas y verrucosas en zonas de flexión y en la mayoría de los casos, las mucosas también resultan afectadas con lesiones papilomatosas. Habitualmente desaparecen con la eliminación del tumor o reaparecen con la recurrencia o metástasis.Acanthosis nigricans malignant is an uncommon paraneoplastic syndrome associated with gastrointestinal tumors, frequently gastric adenocarcinoma, affects both sexes and it has not prevalence by race. Clinically, lesions are hyperpigmented, hypertrophic and verrucous in flexion areas and in most cases the mucous membranes are also affected with papillomatous lesions. Tipically disappears with the removal of the tumor and reappears when recurrence or metastasis occur.
- Published
- 2011
7. Lucio Leprosy with Lucio’s phenomenon, digital gangrene and anticardiolipin antibodies
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F M Macanchi Moncayo, A Clapasson, P F Ortega Espinosa, C Massone, Enrico Nunzie, and L V Ortega Cabrera
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Gangrene ,endocrine system ,Lupus anticoagulant ,Lepromatous leprosy ,Pathology ,medicine.medical_specialty ,business.industry ,Madarosis ,medicine.disease ,Lucio's phenomenon ,medicine ,General Earth and Planetary Sciences ,Histopathology ,Leprosy ,business ,Vasculitis ,hormones, hormone substitutes, and hormone antagonists ,General Environmental Science - Abstract
Lucio's phenomenon (LPh) is considered a necrotizing panvasculitis and a variant of leprosy Type 2 reaction, clinically characterised by necrotic-haemorrhagic lesions on the extremities and trunk. LPh is observed in diffuse lepromatous leprosy (DLL or Lucio-Latapi leprosy). This is a distinct form of lepromatous leprosy (LL) reported mainly in Mexico. Anti-phospholipid antibody syndrome (APS) has been rarely described in LPh. We report a case of Lucio-Latapi leprosy with LPh observed in a patient from the province of El Oro in Ecuador, who presented clinical manifestations of long standing DLL (non-nodular infiltration of the skin, collapse of the nasal pyramid, madarosis, atrophy of the earlobes), of LPh (necrotic-haemorrhagic macules with irregular shapes) and of APS (necrosis of the right big and second toe). Histopathology showed perineural and periadnexal foamy macrophages with numerous bacilli (diagnostic of LL) in the subcutis, a mild lobular panniculitis with a large subcutaneous vessel infiltrated by macrophages in the wall (typical of LPh) and vessels of the superficial and mid dermis occluded by thrombi but without signs of vasculitis (typical of occlusive vasculopathy as in APS). Our observations suggest that some cases of LPh may be associated with APS. Anti-cardiolipin antibodies (aCL) and lupus anticoagulant (LA) should be tested in patients with LPh because this may have therapeutic implications.
- Published
- 2014
8. Papular mycosis fungoides: A new clinical variant of early mycosis fungoides
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Kazuo Kodama, Lorenzo Cerroni, Helmut Kerl, Regina Fink-Puches, and C. Massone
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Adult ,Male ,Mycosis fungoides ,medicine.medical_specialty ,Pathology ,Skin Neoplasms ,CD30 ,business.industry ,Disease progression ,Dermatology ,Middle Aged ,New variant ,medicine.disease ,Peripheral T-cell lymphoma ,Lymphoma ,Mycosis Fungoides ,Disease Progression ,medicine ,Humans ,Immunohistochemistry ,Female ,Lymphomatoid papulosis ,business - Abstract
Background Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma. In early stages of the disease many different clinicopathologic variants have been observed. Observation We report 6 patients with early manifestations of MF characterized by the sole presence of papules which, unlike the papules of lymphomatoid papulosis, did not show a tendency for spontaneous resolution. Histologic examination confirmed the diagnosis of MF in all cases. Immunohistochemical staining for CD30 was negative in all cases. Follow-up data showed the nonaggressive behavior of the disease, confirming that the lesions were not manifestations of advanced MF. Conclusion Papular MF is a new variant of early MF characterized by the presence of papules in the absence of more conventional early lesions (patches) of the disease. This variant should be added to the long list of clinicopathologic subtypes of MF.
- Published
- 2005
9. Cutaneous presentation of recurrence of lymphoepithelioid T-cell lymphoma (Lennert's lymphoma)
- Author
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C. Massone, Matteo Basso, Franco Rongioletti, M. Basso, C. Massone, and Rongioletti, F.
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Pathology ,medicine.medical_specialty ,Skin Neoplasms ,business.industry ,Dermatology ,T lymphocyte ,Middle Aged ,Lymphoma, T-Cell ,medicine.disease ,Lymphoma ,Fatal Outcome ,Recurrence ,hemic and lymphatic diseases ,Abdominal lymph nodes ,medicine ,Humans ,T-cell lymphoma ,Female ,Presentation (obstetrics) ,business ,Lennert lymphoma ,Superficial Lymph Node ,Histiocyte - Abstract
Lennert's lymphoma (LL) is a T-cell lymphoma characterized by the presence of atypical T lymphocytes, admixed with histiocytes and epithelioid granulomas. Patients present with superficial lymph node involvement, mainly in the cervical areas; thoracic adenopathies and involvement of deep abdominal lymph nodes are rare. Cutaneous involvement is infrequent, reported to occur in only 4-11% of patients, and even rarer is the onset of cutaneous lesions as first sign of a recurrence. We report a female patient who presented with papules and nodules on the trunk and upper limbs as the first manifestation of recurrent LL.
- Published
- 2005
10. [Red-orange papule on the cheek of a young woman]
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E, Arzberger, D, Chubisov, C, Massone, and R, Hofmann-Wellenhof
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Adult ,Diagnosis, Differential ,Cheek ,Humans ,Leishmaniasis, Cutaneous ,Female ,Facial Dermatoses - Published
- 2013
11. Clinical and epidemiological comparison of patients affected by palmoplantar plaque psoriasis and palmoplantar pustulosis: a case series study
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A M G, Brunasso, M, Puntoni, W, Aberer, C, Delfino, L, Fancelli, and C, Massone
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Adult ,Male ,Sex Factors ,Arthritis, Psoriatic ,Humans ,Psoriasis ,Female ,Age of Onset ,Middle Aged ,Severity of Illness Index ,Aged ,Retrospective Studies - Abstract
In 2007 the International Psoriasis Council proposed that palmoplantar pustulosis (PPP) should be considered a separate condition from psoriasis, despite the presence of certain phenotypes common in both diseases.To describe and compare demographic and clinical characteristics among patients with PPP and palmoplantar plaque psoriasis.This was a retrospective case series study from 2005 to 2010. The following data were obtained: age, sex, family history, smoking habits, nail involvement, joint involvement, disease duration, lesion morphology (plaque or pustular), histological diagnosis, comorbidities, and Physician's Global Assessment (PGA) score for extrapalmoplantar lesions. The sample size calculation indicated that 80 patients, 40 patients for each group (palmoplantar plaque psoriasis and PPP) were needed to see clinically relevant differences between groups.Ninety patients were selected, 51 with palmoplantar plaque psoriasis and 39 with PPP. No statistically significant differences were registered between patients affected by PPP and palmoplantar plaque psoriasis as regards age at onset of the disease (48 vs. 44 years; P=0·4), disease duration (6 vs. 10 years; P=0·1), family history of psoriasis (28% vs. 33%; P=0·7), concomitant arthritis (26% vs. 25%; P=1·0), or smoking habits (54% vs. 41%; P=0·2). We observed a female predominance (P=0·01) and a lesser frequency of nail involvement (P=0·03) in patients affected by PPP.Our data suggest a close relationship between PPP and psoriasis. The existing data concerning epidemiology, clinical presentation, genetics, histopathology and pathogenesis do not permit a clear distinction between these two entities, which seem to coincide in many aspects. PPP appears to have a marked predilection among female smokers.
- Published
- 2013
12. Drug survival rates of biologic treatments in patients with psoriasis vulgaris
- Author
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A M G, Brunasso, M, Puntoni, and C, Massone
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Male ,Immunoglobulin G ,Anti-Inflammatory Agents ,Antibodies, Monoclonal ,Humans ,Psoriasis ,Female ,Receptors, Tumor Necrosis Factor ,Medication Adherence - Published
- 2011
13. Immunophenotype of skin lymphocytic infiltrate in patients co-infected with Mycobacterium leprae and human immunodeficiency virus: a scenario dependent on CD8+ and/or CD20+ cells
- Author
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C, Massone, C, Talhari, S, Talhari, A M G, Brunasso, T M, Campbell, P, Curcic, L, Cerroni, and R, Ribeiro-Rodrigues
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Adult ,Male ,Granuloma ,Biopsy ,Interleukin-3 Receptor alpha Subunit ,Forkhead Transcription Factors ,HIV Infections ,CD8-Positive T-Lymphocytes ,Middle Aged ,Antigens, CD20 ,Poly(A)-Binding Proteins ,Immunophenotyping ,T-Cell Intracellular Antigen-1 ,Mycobacterium leprae ,Young Adult ,Case-Control Studies ,Leprosy ,Humans ,Female ,Skin Diseases, Infectious ,Skin - Abstract
Leprosy occurs rarely in human immunodeficiency virus (HIV)-positive patients. In contrast to tuberculosis, there has been no report to date of an increase in HIV prevalence among patients with leprosy or of differences in leprosy's clinical spectrum. While several studies describe the systemic immune response profile in patients co-infected with HIV and leprosy, the local immune skin response has been evaluated in only a small number of case reports and limited series of patients.To investigate the interaction between Mycobacterium leprae and HIV infection in the skin.We investigated the presence and frequency of cells positive for CD4, CD8, CD20, TIA-1, FOXP3 and CD123 in lymphocytic infiltrates from 16 skin biopsies taken from 15 patients with HIV-leprosy co-infection.CD4+ cells were absent in infiltrates from 6 (38%) skin biopsies and present in 10 (62%) cases at low levels (1·16%) of the lymphocytic infiltrate. CD8+ was the predominant phenotype in the infiltrate (99·4%), followed by TIA-1, expressed by75% of CD8+ cells. FOXP3+ cells were also present, representing 3·4% of the lymphocytic infiltrate. CD20+ cells were detected in 75% of the cases; however, in two cases (12%) these cells represented 25-50% of the infiltrate, while in the other 10 cases (62%) they were present only focally (25% of the infiltrate). CD123+ cells were not observed in any of the studied specimens.Data presented here suggest that cell-mediated immune responses to M. leprae are preserved at the site of disease and that in the absence of CD4+ cells, CD8+FOXP3+ and CD20+ cells may be involved in granuloma formation.
- Published
- 2011
14. Mobile teledermatology for skin tumour screening: diagnostic accuracy of clinical and dermoscopic image tele-evaluation using cellular phones
- Author
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S, Kroemer, J, Frühauf, T M, Campbell, C, Massone, G, Schwantzer, H P, Soyer, and R, Hofmann-Wellenhof
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Adult ,Aged, 80 and over ,Male ,Skin Neoplasms ,Adolescent ,Decision Making ,Dermoscopy ,Middle Aged ,Telemedicine ,Young Adult ,Child, Preschool ,Humans ,Female ,Child ,Cell Phone ,Mobile Health Units ,Aged - Abstract
The ability to diagnose malignant skin tumours accurately and to distinguish them from benign lesions is vital in ensuring appropriate patient management. Little is known about the effects of mobile teledermatology services on diagnostic accuracy and their appropriateness for skin tumour surveillance.To evaluate the diagnostic accuracy of clinical and dermoscopic image tele-evaluation for mobile skin tumour screening.Over a 3-month period up to three clinical and dermoscopic images were obtained of 113 skin tumours from 88 patients using a mobile phone camera. Dermoscopic images were taken with a dermatoscope applied to the camera lens. Clinical and dermoscopic images of each lesion together with clinical information were separately teletransmitted for decision-making. Results were compared with those obtained by face-to-face examination and histopathology as the gold standard.A total of 322 clinical and 278 dermoscopic images were acquired; two (1%) clinical and 18 (6%) dermoscopic pictures were inadequate for decision-making. After excluding inadequate images, the majority of which were dermoscopic pictures, only 104 of the 113 skin tumours from 80 of 88 patients could be tele-evaluated. Among these 104 lesions, 25 (24%) benign nonmelanocytic, 15 (14%) benign melanocytic, 58 (56%) malignant nonmelanocytic and six (6%) malignant melanocytic lesions were identified. Clinical and dermoscopic tele-evaluations demonstrated strong concordance with the gold standard (κ = 0·84 for each) and similar high sensitivity and specificity for all diagnostic categories. With regard to the detailed diagnoses, clinical image tele-evaluation was superior to teledermoscopy resulting in 16 vs. 22 discordant cases.Clinical image tele-evaluation might be the method of choice for mobile tumour screening.
- Published
- 2011
15. Erythematous macules in a 14-year-old girl
- Author
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C, Massone, D, Kopera, and E, Aberer
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Diagnosis, Differential ,Adolescent ,Erythema ,Humans ,Female ,Telangiectasis ,Skin Diseases, Vascular ,Skin - Published
- 2009
16. Teledermatology
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C, Massone, E M T, Wurm, and H P, Soyer
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Humans ,Telepathology ,Dermoscopy ,Dermatology ,Telemedicine - Abstract
Dermatology is perhaps the most visual specialty in medicine, making it ideally suited for modern telemedicine techniques, as has been shown in a number of recent studies investigating feasibility and reliability of teledermatology. It has generally demonstrated high levels of concordance in diagnosis and management plans compared with face-to-face consultations. Teledermatology has been also used for various purposes, including triage, diagnostic and management services, and second opinion services for primary care practitioners. It has been set up in a number of ways: 1) direct referral for primary care using images and clinical history sent to secondary care dermatology services for second opinion and for triage referrals; and 2) facilitating community-based clinics led by nurses or general practitioners. Moreover, in the last years new fields in teledermatology have grown up. Teledermoscopy is a promising area for melanoma screening as well as for diagnosis and management of equivocal pigmented skin lesions. The feasibility of mobile teledermatology and mobile teledermoscopy has been recently proved and these new facilities have the potential to become an easy applicable tool for everyone and may open the door for a new flexible triage system for detection of skin cancer in general and melanoma in particular. The implementation of virtual slide systems for teledermatopathology has allowed avoiding the limitations imposed by conventional photographs. Finally, web consultations in dermatology are a rather new tool that became available in the last years and teledermatologic services through the Internet offer many possibilities, including continuing medical education, on-line atlases and databases, and specific web application suited for teledermatology (i.e. www.telederm.org).
- Published
- 2008
17. Vicente Huidobro en prosa de combate José De la Fuente A., (2004). Santiago: Ediciones Universidad Católica Silva Henríquez
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C Massone del and Juan Antonio
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Linguistics and Language ,Literature and Literary Theory ,Language and Linguistics - Published
- 2005
18. Contribución bibliográfica sobre el teatro chileno desde 1950 a 2003
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C Massone del and Juan Antonio
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Linguistics and Language ,Literature and Literary Theory ,media_common.quotation_subject ,Art ,Humanities ,Cartography ,Language and Linguistics ,media_common - Abstract
In this work, the author contributes with bibliographical sources, acumulated during half a century on the contemporany chilean theater. Bibliographical pan...
- Published
- 2004
19. Lucio Leprosy with Lucio’s phenomenon, digital gangrene and anticardiolipin antibodies
- Author
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Nunzie, Enrico, primary, Cabrera, Ortega, primary, Moncayo, Macanchi, primary, Espinosa, Ortega, primary, A, Clapasson, primary, and C, Massone, primary
- Published
- 2014
- Full Text
- View/download PDF
20. Ecos y reflejos de nuestra lengua: Discurso con ocasión del Día del Idioma, 23 de abril, 2003
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C Massone del and Juan Antonio
- Subjects
Linguistics and Language ,Literature and Literary Theory ,Language and Linguistics - Abstract
Resumen es: En este discurso conmemorativo de la lengua castellana, el profesor Massone pasa revista a las diversas etapas de la evolucion cultural de nuestro idiom...
- Published
- 2003
21. Allergic contact dermatitis from thiurams with pemphigus-like autoantibodies
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R, Gallo, C, Massone, A, Parodi, and M, Guarrera
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Adult ,Desmoglein 3 ,Emollients ,Desmoglein 1 ,Blotting, Western ,Accidents, Traffic ,Fluorescent Antibody Technique ,Enzyme-Linked Immunosorbent Assay ,Patch Tests ,Thiram ,Cadherins ,Diagnosis, Differential ,Cicatrix ,Thigh ,Latex Hypersensitivity ,Dermatitis, Allergic Contact ,Humans ,Wounds and Injuries ,Female ,Rubber ,Autoantibodies - Published
- 2002
22. Prevalence of stratified epithelium-specific antinuclear antibodies in 138 patients with lichen planus
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Bruno Alibrandi, Alfredo Rebora, G. Ghigliotti, Marina Ciaccio, S. Sorbara, Aurora Parodi, G Cannata, Vittorio Moreno, C. Massone, Gianfranco Muzio, Enrico Scaparro, Paolo Rampini, Giovanni Virno, Pier Mario Isola, Francesco Drago, Giuseppe Santoro, Claudia Micalizzi, Rossella Cestari, Giuseppe Varaldo, Gianfranco Barabino, Luigi Priano, Franco Rongioletti, Luciano Schiazza, Roberto Bandelloni, G. Desirello, Paolo Balbi, Emanuele Cozzani, Stefano Ottoboni, Parodi, A, Cozzani, E, Massone, C, Rebora, A, Priano, L, Ghigliotti, G, Balbi, P, Rongioletti, F, Micalizzi, C, Cestari, R, Varaldo, G, Barabino, G, Cannata, G, Drago, F, Moreno, V, Schiazza, L, Muzio, G, Scaparro, E, Alibrandi, B, Bandelloni, R, Ciaccio, M, Desirello, G, Isola, Pm, Ottoboni, S, Rampini, P, Santoro, G, Sorbara, S, and Virno, G.
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Hepatitis B virus ,Indirect ,Anti-nuclear antibody ,Immunoblotting ,TRIS buffered saline ,Fluorescent Antibody Technique ,Dermatology ,Antibodies ,Epithelium ,Serology ,stomatognathic system ,Antigen ,Antinuclear ,medicine ,Prevalence ,Humans ,Esophagus ,Phosphate-buffered saline ,Fluorescent Antibody Technique, Indirect ,Direct fluorescent antibody ,Sodium dodecyl sulfate ,Antinuclear antibodies directed to stratified epithelia ,biology ,Indirect immunofluorescence ,business.industry ,Hepatitis C virus ,Lichen Planus ,IIf ,Middle Aged ,stomatognathic diseases ,medicine.anatomical_structure ,Antibodies, Antinuclear ,Immunology ,biology.protein ,Female ,Antibody ,business ,Lichen planus - Abstract
Background: Antibodies to stratified epithelia characterize chronic ulcerative stomatitis, an entity that very closely resembles erosive lichen planus both clinically and histologically. These antibodies are directed against a 70-kd antigen. Objective: Our aim was to verify whether antibodies to stratified epithelia are present in patients with common lichen planus. Patients and methods: One hundred thirty-eight patients with various forms of lichen planus were studied. Indirect immunofluorescence was performed on both monkey esophagus and HEp2-2000 cells. Immunoblotting was done with cultured keratinocytes used as the source antigen. Results: Nineteen patients had antibodies to stratified epithelia (in 9 directed against an antigen of 70 kd). Forty-eight patients had circulating antibodies detected by indirect immunofluorescence on both monkey esophagus and HEp2-2000 cells (in 7 directed against an antigen of 70 kd). Indirect immunofluorescence was positive only on HEp2-2000 cells in 21 patients. Indirect immunofluorescence was negative in 50 patients on both HEp2-2000 cells and monkey esophagus. None of the last 71 patients had antibodies directed to an antigen of 70 kd. Limitations: This is a serological study; results from direct immunofluorescence studies would be interesting. Conclusion: Antibodies to stratified epithelia directed to an antigen of 70 kd are not exclusive to chronic ulcerative stomatitis, but are also present in some patients with lichen planus. © 2007 American Academy of Dermatology, Inc.
- Published
- 2002
23. Multiple eruptive dermatofibromas in patients with systemic lupus erythematosus treated with prednisone
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Andrea Parodi, G. Virno, Alfredo Rebora, and C. Massone
- Subjects
medicine.medical_specialty ,Systemic disease ,Pathology ,Benign Fibrous ,Skin Neoplasms ,Anti-nuclear antibody ,Anti-Inflammatory Agents ,Dermatology ,Drug Eruptions ,Female ,Histiocytoma, Benign Fibrous ,Humans ,Lupus Erythematosus, Systemic ,Middle Aged ,Prednisone ,medicine ,skin and connective tissue diseases ,Lupus erythematosus ,Histiocytoma ,medicine.diagnostic_test ,Lupus Erythematosus ,business.industry ,Systemic ,Hydroxychloroquine ,medicine.disease ,Erythrocyte sedimentation rate ,medicine.symptom ,Malar rash ,business ,Anti-SSA/Ro autoantibodies ,medicine.drug - Abstract
Solitary dermatofibromas are a common occurrence, especially on the lower limbs of young women, while multiple dermatofibromas (MDF) are rare, accounting for less than 0.3% of all dermatofibromas and may suddenly develop in immunosuppressed patients. We report a patient with systemic lupus erythematosus (SLE) who developed MDF while she was taking oral prednisone. A 46-year-old woman presented in 1989 complaining of photosensitivity, arthralgias, fatigue, malaise and dyspepsia. The patient denied fever, Raynaud's phenomenon, oral ulcer and hair loss. On examination she presented a typical SLE malar rash. Erythrocyte sedimentation rate (ESR) was elevated (54 mm/h). Speckle patterned IgG/IgM antinuclear antibodies were present at 1/1280 titer. Antibodies anti Ro/SSA were detected by counterimmunelectrophoresis up to 1/8 titer. Other laboratory findings were negative or within normal limits. Systemic lupus erythematosus was diagnosed and the patient given 50 mg/day prednisone. After a few months, both clinical symptoms and immunologic parameters improved. Eighteen months later, prednisone was replaced by 500 mg/day hydroxychloroquine. In 1994, she presented again with malar rash, arthralgias and facial hyperpigmentation. Prednisone 15 mg/day was reintroduced and hydroxychloroquine stopped being a possible cause of the facial hyperpigmented macules. In 1996, while she was taking 5 mg/day prednisone, several nodules developed on her limbs within a few months. On examination we observed 16 firm, slightly elevated 3-15-mm wide brown nodules on her arms, legs and trunk. A biopsy specimen of a lesion of the trunk revealed an epidermal seborrheic-keratosis-like hyperplasia with dermal fibrosis and fibroblastic proliferation (Fig. 1). Dermatofibroma was diagnosed.
- Published
- 2002
24. Erythema Multiforme-like Subacute Cutaneous Lupus Erythematosus: A New Variety?
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Andrea Parodi, Alfredo Rebora, and C. Massone
- Subjects
Erythema Multiforme ,medicine.medical_specialty ,Lupus Erythematosus ,Aged ,Diagnosis, Differential ,Female ,Humans ,Lupus Erythematosus, Cutaneous ,business.industry ,Dermatology ,General Medicine ,medicine.disease ,Subacute cutaneous lupus erythematosus ,Cutaneous ,Diagnosis ,Differential ,medicine ,Erythema multiforme ,business - Published
- 2000
25. Feasibility and diagnostic agreement in teledermatopathology using a virtual slide system
- Author
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Ismini Vassilaki, Lorenzo Cerroni, Masoud Asgari, Shahbaz A. Janjua, Gerardo Ferrara, Alessandro Di Stefani, Bernhard Zelger, H. Peter Soyer, Kazuo Kodama, Gerald Gabler, Borut Žgavec, Gian Piero Lozzi, Darius R. Mehregan, Franco Rongioletti, Vincenzo Canzonieri, Helmut Kerl, Cesare Massone, Bernd Leinweber, Renata Boldrini, Vahid Mashayekhi, Leonardo Bugatti, Massone, C, Soyer, Hp, Lozzi, Gp, Di Stefani, A, Leinweber, B, Gabler, G, Asgari, M, Boldrini, R, Bugatti, L, Canzonieri, V, Ferrara, G, Kodama, K, Mehregan, D, Rongioletti, F, Janjua, Sa, Mashayekhi, V, Vassilakio, I, Zelger, B, Zgavec, B, Cerroni, L, Kerl, H, C, Massone, H, PETER SOYER, Gp, Lozzi, A, DI STEFANI, B, Leinweber, G, Gabler, M, Asgari, R, Boldrini, L, Bugatti, V, Canzonieri, G, Ferrara, K, Kodama, D, Mehregan, Rongioletti, F., Sa, Janjua, V, Mashayekhi, I, Vassilaki, B, Zelger, B, Zgavec, L, Cerroni, and H, Kerl
- Subjects
Adult ,Male ,Teledermatology ,medicine.medical_specialty ,Telemedicine ,Adolescent ,Biopsy ,Concordance ,Telepathology ,Dermatology ,Skin Diseases ,Pathology and Forensic Medicine ,User-Computer Interface ,80 and over ,medicine ,Humans ,Child ,Virtual slide ,Aged ,Aged, 80 and over ,Observer Variation ,business.industry ,Inflammatory skin disease ,Gold standard (test) ,Middle Aged ,Teledermatopathology ,Surgery ,Virtual slide system ,Feasibility Studies ,Female ,Radiology ,business - Abstract
We investigated the feasibility and diagnostic agreement of a virtual slide system (VSS) in teledermatopathology. Forty-six biopsy specimens from inflammatory skin diseases were selected and scanned with a VSS at the Research Unit of Teledermatology, Medical University of Graz, Graz, Austria. Images were stored oil a virtual slide server on which a specific Web application suited for telepathology (http://telederm.org/research/dermatopath/) runs. Twelve teleconsultants from 6 different Countries reviewed the 46 cases, working directly oil the Web application. Telediagnoses agreed with gold standard and conventional diagnosis with an average of 73% and 74%, respectively. Complete concordance among all teleconsultants with gold standard and conventional diagnosis was found in 20% of the cases. In 10 cases in which complete clinical data were missing, the average agreement of telediagnosis with gold standard diagnosis and conventional diagnosis decreased to 65% and 66%, respectively. Only 3 of 4 cases of inflammatory skin diseases were correctly diagnosed remotely with VSS. The system that we have used, despite its usability, is not completely feasible for teledermatopathology of inflammatory skin disease. Moreover, the performance seems to have been influenced by the availability of complete clinical data and by the intrinsic difficulty of the pathology of inflammatory skin diseases. (c) 2007 Elsevier Inc. All rights reserved. RI Soyer, H. Peter/E-6000-2010
- Published
- 2007
26. The multidisciplinary approach in primary cutaneous lymphomas.
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Massone C and Ferrara G
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- 2024
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27. Systemic treatments with monoclonal antibodies in mycosis fungoides and Sézary syndrome.
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Ibatici A, Angelucci E, and Massone C
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Mycosis fungoides (MF) and Sézary syndrome (SS) are the most prevalent non-Hodgkin lymphomas that comprise cutaneous T-cell lymphomas (CTCL), accounting for more than 70% of cases. Following the Tumor Lymph nodes Metastasis Blood system, disease staging is carried out, and within ten years, about thirty percent of patients in the early stages will have advanced disease. Plaques, folliculotropism, and age over 60 are risk factors for progression. A 5-year survival rate of less than 20% is associated with LCT in MF. Treatment requires an interdisciplinary approach; skin-directed therapies are available for early stages of the disease, but there are no curative options for advanced stages of the disease other than allogeneic stem cell transplantation. Because of their severe symptoms and poor treatment efficacy, patients in advanced stages have a lower quality of life and a lower chance of survival. In patients with CD30-expressing CTCL, Brentuximab Vedotin has demonstrated better response rates and progression-free survival (PFS); in advanced SS, mogamulizumab has significantly increased PFS. These findings emphasize the need to standardize prognostic factors and improve CTCL treatment., Competing Interests: Conflict of interest: the authors declare no potential conflict of interest., (Copyright © 2024, the Author(s).)
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- 2024
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28. Effectiveness and tolerability of chlormethine gel for the management of mycosis fungoides: a multicenter real-life evaluation.
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Alberti-Violetti S, Ardigò M, Massone C, Pileri A, Sala R, Teoli M, Grandi V, Quaglino P, Pimpinelli N, and Berti E
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Background: Topical chlormethine (CL) is recommended as a first-line treatment for early-stage mycosis fungoides (MF) and in 2017, the European Medicines Agency approved the CL gel formulation to treat adult patients. More recently, to increase patient compliance and adherence, clinicians have developed flexible protocols that allow the concomitant use of CL gel with topical corticosteroids in daily practice regimens. Therefore, sharing real-life data on CL gel use and side effects management may help improve the use of this agent., Objectives: To expand knowledge about the actual use of CL gel in patients with MF, the present study assessed the improvement of MF skin lesions after CL gel treatment and provided information on the management of cutaneous adverse events (AEs) in a real-life setting., Methods: This was an Italian retrospective study conducted among six dermatology referral centers. Patients ≥18 years affected by MF and in treatment with CL gel (160 µ/g), alone or in combination according to routine clinical practice, between December 2019 and December 2021 were considered. The study's primary aim was to evaluate the effectiveness of CL gel in terms of overall response rate (ORR) after 3 months of treatment., Results: A total of 79 patients (61% male) with different stages of MF (84% early stage) were included. CL gel was prescribed mainly in association with topical corticosteroids (66% of patients). ORR after 3 months of treatment was 42%, with no differences between early- and advanced-stage MF. Response rates improved over time up to 97% after 18 months of treatment. Overall, 66 AEs were reported in 67% of patients; most were hyperpigmentation (45%) and irritant contact dermatitis (37%). Six AEs led to treatment discontinuation, and five out of six (83%) patients who reported these events resumed treatment after interruption. No AEs were classified as severe., Conclusions: Our observations support the use of CL gel in patients with early- and advanced-stage MF, making it a valuable treatment option., Competing Interests: SA-V: advisory board from Takeda, Kyowa Kirin, Helsinn-Recordati; CM: advisory board from Takeda, Kiowa Kirin; PQ: advisory board and speaker fee from Takeda, Kyowa Kirin, Celgene, Helsinn-Recordati, Therakos. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Alberti-Violetti, Ardigò, Massone, Pileri, Sala, Teoli, Grandi, Quaglino, Pimpinelli and Berti.)
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- 2024
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29. A rare and severe lichenoid skin eruption after apalutamide treatment for prostate cancer.
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Guglielmini PF, Massone C, Grasso C, Francese A, Vincenti M, Chiodi S, Rossi M, and Maconi A
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- 2023
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30. Histopathological Markers for Target Therapies in Primary Cutaneous Lymphomas.
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Sonego B, Ibatici A, Rivoli G, Angelucci E, Sola S, and Massone C
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- Humans, Brentuximab Vedotin therapeutic use, Antibodies, Monoclonal therapeutic use, Skin Neoplasms pathology, Mycosis Fungoides pathology, Sezary Syndrome pathology, Antineoplastic Agents therapeutic use
- Abstract
In recent years, targeted (biological) therapies have become available also for primary cutaneous T-cell lymphomas (PCTCLs) including anti-CD30 (brentuximab vedotin) in mycosis fungoides, primary cutaneous anaplastic large T-cell lymphoma, lymphomatoid papulosis; anti-CCR4 (mogamulizumab) in Sezary syndrome; anti-CD123 (tagraxofusp) in blastic plasmocytoid cell neoplasm. Moreover, anti-PD1 (nivolumab), anti-PDL1 (pembrolizumab, atezolizumab), anti-CD52 (alemtuzumab), anti-KIR3DL2-CD158k (lacutamab), and anti-CD70 (cusatuzumab) have been tested or are under investigations in phase II trials. The expression of these epitopes on neoplastic cells in skin biopsies or blood samples plays a central role in the management of PCTCL patients. This narrative review aims to provide readers with an update on the latest advances in the newest therapeutic options for PCTCLs.
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- 2023
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31. Anisakis simplex and urticaria. What we know about its real incidence and management in dermatological settings?
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Javor S, Bignardi D, Borro M, and Massone C
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Acute or chronic infections have been described among causes of chronic urticaria (CU). Anisakidosis is a human disease caused by the ingestion of larval nematodes of the family Anisakidae. The infestation is acquired by eating raw seafood or undercooked fish and squid. There are considerable variations in the frequency of underlying causes in the different studies and in different countries, such as differences in diets and the prevalence of infections. Anisakis simplex has been recognized as a trigger of both acute and CU manifestations. However, there is still a lack of evidence about its management and treatment in dermatology. We, therefore, reviewed some biologic properties of Anisakis simplex in order to understand the relationship between its biology and the mechanism it uses to establish chronic dermatological conditions such as urticaria and cause late complications. In addition, we herein report some concerns about the effectiveness of systemic treatment in preventing complications and management in dermatological settings., Competing Interests: Conflict of interest: the authors declare no potential conflict of interest., (Copyright © 2024, the Author(s).)
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- 2023
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32. Prevalence of pruritus in the elderly in an outpatient dermatologic clinic: a monocentric pilot study.
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Javor S, Priano L, Anonide A, and Massone C
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Few studies have examined pruritus in elderly patients, a common dermatological condition. The study examines pruritus prevalence and characteristics in elderly patients referred to the Dermatology Unit, at Genoa's Galliera Hospital. The demographic characteristics of all Outpatient Clinic patients with any skin condition were examined, focusing on pruritus patients over 65. Pruritus was present in 36/262 patients (14%; M:F =20:16; mean age: 59.55 years). About 14% of 140 patients aged ≥65 years had pruritus, with 20/262 (8%; M:F =14:6; mean age: 74.6 years) exhibiting it. Visual analog score pruritus did not differ between patients aged ≥65 years (20/36) and <65 years (16/36) statistically. In 89% of patients, itch was related to a dermatological condition, mainly psoriasis. Only extracutaneous diseases resulted more frequently in the patients aged >65. No anamnestic link was found between drug use and pruritus in these patients. We confirm that pruritus is a common skin problem that affects both sexes, young and old, and is almost always caused by an underlying skin condition (mainly psoriasis). It is rarely caused by a new drug., Competing Interests: Conflict of interest: the authors declare no potential conflict of interest., (Copyright © 2024, the Author(s).)
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- 2023
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33. Blastic plasmacytoid dendritic cell neoplasm: a short review and update.
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Massone C, Rivoli G, Sola S, and Angelucci E
- Abstract
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic neoplasm (less than 1% of primary cutaneous lymphomas and acute leukemia) with a highly aggressive clinical course and frequent skin, bone marrow and central nervous system involvement. Even though there is often an early response to chemotherapy, leukemic dissemination relapses are very common and result in poor outcomes, with a median overall survival of 8 to 14 months in the first-line setting using standard combination chemotherapy regimens. Almost 90% of patients experience skin involvement as their initial site of infection, where BPDCN may stay restricted for weeks or even months until a swift secondary phase involving multiple organs takes place. Consequently, it is crucial to suspect and identify early skin lesions, as well as to conduct and report a skin biopsy as soon as possible. In order to diagnose and treat BPDCN, a multidisciplinary strategy involving collaboration between pathologists, hematologists, and dermatologists is unquestionably essential., Competing Interests: Conflict of interest: the authors declare no potential conflict of interest., (Copyright © 2024, the Author(s).)
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- 2023
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34. A group of three miRNAs can act as candidate circulating biomarkers in liquid biopsies from melanoma patients.
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De Martino E, Gandin I, Azzalini E, Massone C, Pizzichetta MA, Giulioni E, Javor S, Pinzani C, Conforti C, Zalaudek I, and Bonin S
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Background: Staging of melanoma and follow up after melanoma diagnosis aims at predicting risk and detecting progression or recurrence at early stage, respectively in order to timely start and/or change treatment. Tumor thickness according to Breslow, status of the sentinel node and value of the lactate dehydrogenase (LDH) are well-established prognostic markers for metastatic risk, but reliable biomarkers identifying early recurrence or candidates who may benefit best from medical treatment are still warranted. Liquid biopsy has emerged to be a suitable method for identifying biomarkers for early cancer diagnosis, prognosis, therapeutic response prediction, and patient follow-up. Liquid biopsy is a blood-based non-invasive procedure that allows analyzing circulating analytes, including extracellular vesicles., Methods: In this study we have explored the use of 7 miRNAs, namely hsa-miR-149-3p, hsa-miR-150-5p, hsa-miR-21-5p , hsa-miR-200c-3p, hsa-miR-134-5p, hsa-miR-144-3p and hsa-miR-221-3p in plasma exosomes to discriminate melanoma patients from controls without melanoma in a cohort of 92 individuals., Results and Discussion: Our results showed that three out seven miRNAs, namely hsa-miR-200c-3p, hsa-miR-144-3p and hsa-miR-221-3p were differentially expressed in plasma-derived exosomes from melanoma patients and controls. Furthermore, the expression of the three miRNAs may be a promising ancillary tool as a melanoma biomarker, even for discriminating between nevi and melanoma., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 De Martino, Gandin, Azzalini, Massone, Pizzichetta, Giulioni, Javor, Pinzani, Conforti, Zalaudek and Bonin.)
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- 2023
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35. Two cases of granuloma faciale showing rosettes.
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Sonego B, Sola S, Biondo G, and Massone C
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Granuloma faciale (GF) is a rare benign chronic inflammatory dermatosis often difficult to distinguish clinically from other diseases, both inflammatory and neoplastic. Dermoscopy can be a helpful diagnostic tool and indeed several dermoscopic criteria observed in GF have been described in literature. We present two patients affected by GF in which we have observed rosettes., Competing Interests: Conflict of interest: the authors declare no potential conflict of interest., (Copyright © 2023, the Author(s).)
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- 2023
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36. Hypomelanotyc Basomelanocytic Tumor.
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Massone C, Javor S, Chiodi S, and Sola S
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- 2023
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37. Real-world data on primary cutaneous lymphoproliferative disorders following SARS-CoV-2 vaccination: A multicentre experience from tertiary referral hospitals.
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Avallone G, Maronese CA, Conforti C, Fava P, Gargiulo L, Marzano AV, Massone C, Mastorino L, Paradisi A, Pileri A, Quaglino P, Rizzo N, Ribero S, Roccuzzo G, Tavoletti G, Vignoli CA, Zalaudek I, Berti E, and Alberti-Violetti S
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- Humans, Tertiary Care Centers, SARS-CoV-2, Vaccination, COVID-19 Vaccines adverse effects, COVID-19 epidemiology, COVID-19 prevention & control
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- 2023
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38. Teledermatopathology on the ADOI platform and beyond.
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Massone C, Perasole A, and Naldi L
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- 2023
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39. Clinicopathologic and Dermoscopic Features of 20 Cases of Spark's Nevus, a Dermoscopic Simulator of Melanoma.
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Massone C, Stanganelli I, Ingordo V, Ferrara G, Brunasso AMG, Siri G, Casazza S, Gnone M, Pizzichetta MA, Giovanni B, Chiodi S, and Sola S
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- Young Adult, Humans, Dermoscopy, Skin Neoplasms pathology, Sunburn, Nevus pathology, Nevus, Pigmented pathology, Melanoma diagnosis, Melanoma pathology, Nevus, Epithelioid and Spindle Cell, Hyperpigmentation
- Abstract
Abstract: Spark's nevus is a particular type of melanocytic nevus, with histology that shows features of both Spitz and Clark nevus. Detailed dermoscopic features in a series of Spark nevi have not been described yet. We performed a monocentric retrospective observational study on 20 lesions of Spark nevus excised from 19 patients (M:F = 10:9; mean age: 37,6 years), reviewed by 5 experts in dermoscopy and 2 dermatopathologists. A histologic review confirmed that Spark nevi were mostly symmetric (80%), well circumscribed (100%), mainly compound (65%) melanocytic lesions with either epithelioid (55%) or spitzoid (45%) cell morphology and bridging of the nests (100%). Spark nevi were more frequently found on the trunk (85%) in patients with a history of sunburns in childhood (84%), with skin phototype III (79%), and with high nevus count (>100 nevi, 7 patients (36%)). On dermoscopy, we observed different general patterns: multicomponent (40%), reticular-globular-homogeneous (15%), globular homogeneous (15%), reticular (15%), reticular-globular (5%), homogeneous (5%), and globular (5%). Spark nevi showed frequently dermoscopic asymmetry (63%), brown color (90%) with areas of central hyperpigmentation (41%) and peripheral hypopigmentation (28%), atypical pigment network (48%), irregular globules (42%), irregular dots (31%), irregular blotches (16%), blue-whitish veil (13%), peripheral island (25%), irregular hyperpigmented areas (12%), and regression (33%). BRAF mutation was present in 7 of the 10 analyzed cases (70%); all these cases presented a history of evolution. In conclusion, Spark nevi occur on the trunk of young adults with high nevus count and history of sunburns; dermoscopic features are protean, often atypical and suspicious of melanoma., (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2023
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40. Cutaneous Squamomelanocytic Tumor: An Additional Case Report With Dermoscopic Features.
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Massone C, Chiodi S, Zanette M, and Sola S
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- Humans, Dermoscopy, Skin Neoplasms, Melanoma surgery
- Abstract
Competing Interests: The authors declare no conflicts of interest.
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- 2023
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41. A case of angiomatoid Spitz Nevus in the elderly, with clinical and dermoscopic features.
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Luongo G, De Stefano N, Perasole A, Massone C, and Galdo G
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- 2023
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42. Italian Real-Life Experience on the Use of Mogamulizumab in Patients with Cutaneous T-Cell Lymphomas.
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Caruso L, Castellino A, Dessì D, Flenghi L, Giordano A, Ibatici A, Massone C, Pileri A, Proietti I, Pupo L, Quaglino P, Rupoli S, and Zinzani PL
- Abstract
Mycosis fungoides and Sèzary syndrome are the most studied subtypes common cutaneous T-cell lymphomas. The current treatment objective is to improve the clinical manifestations of the disease in the affected areas, to relieve symptoms and to halt disease progression. Patients with early-stage mycosis fungoides are usually managed with skin-directed therapies, whereas patients with resistant or advanced-stage mycosis fungoides or Sèzary syndrome often require systemic drugs. Over the last decade, new drugs have been developed, increasing the breadth of treatment options for cutaneous T-cell lymphomas patients. Mogamulizumab is a first-in-class defucosylated humanized IgG1 κ monoclonal antibody, which exerts its anti-tumour action by selectively binding to C-C chemokine receptor 4 and increasing antibody-dependent cellular cytotoxicity activity against malignant T-cells. Several clinical trials showed that mogamulizumab is able to effectively control the cutaneous T-cell lymphomas in each site (skin, blood, lymph nodes and viscera), improving patients' symptoms, function and overall quality of life with a manageable safety profile. In this report, we discuss 12 cases of patients with mycosis fungoides or Sèzary syndrome successfully treated with mogamulizumab in real-life clinical practice in Italy., Competing Interests: Pier Luigi Zinzani received consultant fees from MSD, Eusapharma and Novartis; speaker fees from Celltrion, Gilead, Janssen-Cilag, BMS, Servier, MSD, TG Therap, Takeda, Roche, Eusapharma, Kyowa Kirin, Novartis, Incyte and Beigene; Advisory Board fees from Secura-Bio, Celltrion, Gilead, Janssen-Cilag, BMS, Servier, Sandoz, MSD, TG Therap, Takeda, Roche, Eusapharma, Kyowa Kirin, Novartis, ADC Therapy, Incyte and Beigene. Pietro Quaglino received speaker and advisory board fees from Kyowa Kirin, Takeda, Therakos Cellgene, Helsinn, Recordati, 4 SC. Cesare Massone received speaker and advisory board fees from Kyowa Kirin, Takeda. The other authors report no conflicts of interest in this work., (© 2022 Caruso et al.)
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- 2022
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43. Dermoscopic features of Monkeypox virus skin infection.
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Giovanni B and Massone C
- Abstract
Competing Interests: Conflict of interest: The authors declare no potential conflict of interest.
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- 2022
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44. The relevance of complete imaging investigations in lymphomatoid papulosis.
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Chersi F, Sola S, Piccardo A, and Massone C
- Abstract
Competing Interests: Conflict of interest: The authors declare no potential conflict of interest.
- Published
- 2022
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45. A consensus-based approach on the management of patients with both psoriasis and psoriatic arthritis in the dermatological and rheumatological settings in Italy: The ADOI PSO-Amore Project.
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Cusano F, Sampogna F, Brunasso Vernetti AMG, Stisi S, Sandri G, Malara G, Naldi L, Pellegrino M, Tripepi GL, di Luzio Paparatti U, Agnusdei CP, Bonifati C, Celano A, Corazza V, D'Agostino F, De Pasquale R, Filippucci E, Foti R, Galdo G, Gai F, Ganzetti G, Graceffa D, Maccarone M, Mazzotta A, Melchionda G, Molinaro F, Paoletti F, Tonolo S, Vercellone A, Vitetta R, Massone C, and Sebastiani GD
- Abstract
Psoriasis is a complex disease often needing a multidisciplinary approach. In particular, the collaboration between dermatologist and rheumatologist is crucial for the management of patients suffering from both psoriasis (PSO) and psoriatic arthritis (PsA). Here we report a series of recommendations from a group of experts, as a result of a Consensus Conference, defining the circumstances in which it is preferable or even mandatory, depending on the available settings, to rely on the opinion of the two specialists, jointly or in a deferred manner. Indications are given on how to organize a 3
rd level joint Dermatology- Rheumatology care unit, in connection with 1st and 2nd level clinicians of both specialties, GPs, and other specialists involved in the management of psoriasis. A potential patient journey is suggested, that can be used as a basis for future design and validation of national and/or local diagnostic therapeutic and assistance pathways., (©Copyright: the Author(s).)- Published
- 2022
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46. Gingival crevicular fluid from pregnant women impairs trophoblast cell function and trophoblast-neutrophil interaction.
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Hauk V, D'Eramo L, Calo G, Merech F, Doga L, Lara B, Gliosca L, Massone C, Molgatini S, Ramhorst R, Squassi A, and Pérez Leirós C
- Subjects
- Female, Gingival Crevicular Fluid, Glucose, Humans, Neutrophils, Placenta, Pregnancy, Reactive Oxygen Species, Trophoblasts, Pre-Eclampsia, Pregnancy Complications
- Abstract
Problem: A strong association between periodontitis and higher susceptibility to pregnancy complications like preeclampsia has been reported although the mechanisms remain elusive. Trophoblast cells modulate the recruitment and functional shaping of maternal leukocytes at early stages to sustain an antiinflammatory microenvironment and fetal growth. Neutrophil activation with reactive oxygen species (ROS) release is associated with preeclampsia. Our aim was to study the effect of the gingival crevicular fluid (GCF) from pregnant women on trophoblast cell function and trophoblast-neutrophil interaction., Method of Study: Pregnant women at 16-20 weeks of gestation (n = 27) and non-pregnant women (n = 8) as the control group were studied for gingivoperiodontal clinical score evaluation and GCF collection. Total bacteria and common periodontal pathogens were analyzed in GCF samples. The effect of each GCF sample was tested on first trimester trophoblast-derived cells to assess cell migration, cytokine expression and glucose uptake. Also, the effect of GCF on human peripheral neutrophil chemoattraction by trophoblast cells and ROS formation was assessed., Results: Gingival crevicular fluid from pregnant women reduced trophoblast cell migration, increased proinflammatory marker expression and glucose uptake. A significant correlation between gingivoperiodontal score and trophoblast dysfunction was observed. Upon conditioning of trophoblast cells with GCF, only the GCF from pregnant women stimulated neutrophil chemoattraction. Similarly, GCF from pregnant but not from non-pregnant controls stimulated ROS formation in neutrophils., Conclusions: Gingival crevicular fluid from pregnant women is deleterious for first trimester trophoblast cell function. These effects could lead to placental homeostasis disruption underlying a pathogenic mechanism of pregnancy complications associated to periodontal disease., (© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2022
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47. Healthcare and safety of patients with melanoma during the COVID-19 Pandemic in Italy.
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Caini S, Brusasco M, Niero G, De Giorgi V, Lombardo M, Massone C, Medri M, Palmieri G, Pizzichetta MA, Quaglino P, Satta R, Feliciani C, Gandini S, and Stanganelli I
- Subjects
- Delivery of Health Care, Humans, Italy epidemiology, Pandemics, SARS-CoV-2, COVID-19, Melanoma epidemiology
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- 2022
- Full Text
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48. Consensus on the place in therapy of biologics in the treatment of patients with chronic plaque psoriasis.
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Burlando M, Baldari M, Brunasso Vernetti AM, Cannata G, Massone C, Pestarino A, Stradini D, and Parodi A
- Subjects
- Consensus, Humans, Biological Products therapeutic use, Psoriasis drug therapy
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- 2022
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49. Skin manifestations in patients with coronavirus disease 2019.
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Bassetti M, Massone C, Vena A, Dettori S, Conforti C, Giacobbe DR, and Zalaudek I
- Subjects
- Adult, Child, Humans, SARS-CoV-2, Skin pathology, COVID-19 complications
- Abstract
Purpose of Review: Coronavirus disease 2019 (COVID-19) is a well established respiratory tract illness. Recent studies in adults and children have shown an increasing number of patients reporting polymorphic cutaneous manifestations during COVID-19, including different types of rashes, from maculopapular, vascular, vesicular to atypical forms., Recent Findings: Although pathogenesis of skin manifestations is still not fully understood, it has been proposed that cutaneous involvement during COVID-19 may be the results of the activation of the immune response against severe acute respiratory syndrome coronavirus-2, the reactivation or co-infection of herpesviruses or drug hypersensitivity., Summary: According to available literature, skin manifestations in patients with COVID-19 may be categorized on the basis of their clinical presentations as follows: erythematous rashes, lesions of vascular origin, vesicular rash, urticarial rash and acute generalized exanthematous pustulosis (AGEP), erythema multiforme and other polymorphic erythema/atypical reactions. Prompt recognition of these cutaneous manifestations represents a crucial point to facilitate diagnosis and management of COVID-19 patients., (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2022
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50. Fifteen years of melanomatous meetings.
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Perasole A and Massone C
- Published
- 2022
- Full Text
- View/download PDF
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