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1. On the physicochemical properties, setting chemical reaction, and in vitro bioactivity of aragonite–chitosan composite cement as a bone substitute

Author

E. Toufik, H. Noukrati, C. Rey, O. Marsan, C. Charvillat, S. Cazalbou, H. Ben Youcef, A. Barroug, and C. Combes

Subjects
Materials Chemistry, General Chemistry, Catalysis
Abstract

A chitosan gel additive modulates the initial vaterite dissolution–recrystallisation in injectable aragonite-based composite cement and promotes its in vitro bioactivity.

Published
2023

2. Robocasting of self-setting bioceramics: from paste formulation to 3D part characteristics

Author

A. Paterlini, S. Le Grill, F. Brouillet, C. Combes, D. Grossin, and G. Bertrand

Subjects
Robocasting, Self-setting ceramic, Scaffolds, Calcium sulphate, Apatite, Clay industries. Ceramics. Glass, TP785-869
Abstract

This study aims to investigate the feasibility of generating three-dimensional scaffold structures by robocasting 3D printing for bone tissue engineering and anatomical model applications. Robocasting is an additive manufacturing process that generates parts directly from CAD draws in a layer-wise manner, enabling the construction of complex 3D structures with controlled chemistry and specific interconnected porosity. Our strategy was based on the reactivity of the involved components in mineral bone cement or plaster self-setting pastes, but the simultaneity of manufacturing process and chemical setting reactions required a careful adaptation of paste formulations to secure enough time to fabricate a 3D scaffold under homogeneous extruding conditions at room temperature. The two self-setting pastes reactions studied in the present work were the transformation of calcium sulphate hemi-hydrate into gypsum and a mixture of brushite and vaterite into apatite. Additives such as carboxymethyl cellulose (CMC) or polyvinyl alcohol (PVA) were introduced in limited amounts (2–3% for CMC and 9–13% for PVA) in the self-setting paste formulations to favour extrusion while achieving self-standing brands. To complete the 3D scaffold setting reaction, a post-drying protocol was developed. 3D parts of various sizes and architectures were produced. Their crystalline phase and chemical composition characterisations allowed establishing the progress of the chemical setting reaction for all the pastes. A rheological study allowed defining a common trend for all the extruded pastes. Compression tests presented great mechanical properties of plaster 3D samples, particularly improved by the presence of PVA, while water absorption study presented suitable values for all the compositions, according to their different applications.

Published
2021
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4. Psychiatric and physical outcomes of long-term use of lithium in older adults with bipolar disorder and major depressive disorder: A cross-sectional multicenter study

Author

Elise Morlet, Jean-François Costemale-Lacoste, Emmanuel Poulet, Kibby McMahon, Nicolas Hoertel, Frédéric Limosin, J Adès, C Alezrah, I Amado, G Amar, O Andréi, D Arbault, G Archambault, G Aurifeuille, S Barrière, C Béra-Potelle, Y Blumenstock, H Bardou, M Bareil-Guérin, P Barrau, C Barrouillet, E Baup, N Bazin, B Beaufils, J Ben Ayed, M Benoit, K Benyacoub, T Bichet, F Blanadet, O Blanc, J Blanc-Comiti, D Boussiron, AM Bouysse, A Brochard, O Brochart, B Bucheron, M Cabot, V Camus, JM Chabannes, V Charlot, T Charpeaud, C Clad-Mor, C Combes, M Comisu, B Cordier, F Costi, JP Courcelles, M Creixell, H Cuche, C Cuervo-Lombard, A Dammak, D Da Rin, JB Denis, H Denizot, A Deperthuis, E Diers, S Dirami, D Donneau, P Dreano, C Dubertret, E Duprat, D Duthoit, C Fernandez, P Fonfrede, N Freitas, P Gasnier, J Gauillard, F Getten, F Gierski, F Godart, R Gourevitch, A Grassin Delyle, J Gremion, H Gres, V Griner, C Guerin-Langlois, C Guggiari, O Guillin, H Hadaoui, E Haffen, C Hanon, S Haouzir, C Hazif-Thomas, A Heron, B Hubsch, I Jalenques, D Januel, A Kaladjian, JF Karnycheff, O Kebir, MO Krebs, C Lajugie, M Leboyer, P Legrand, M Lejoyeux, V Lemaire, E Leroy, D Levy-Chavagnat, A Leydier, C Liling, PM Llorca, P Loeffel, P Louville, S Lucas Navarro, N Mages, M Mahi, O Maillet, A Manetti, C Martelli, P Martin, M Masson, I Maurs-Ferrer, J Mauvieux, S Mazmanian, E Mechin, L Mekaoui, M Meniai, A Metton, A Mihoubi, M Miron, G Mora, V Niro Adès, P Nubukpo, C Omnes, S Papin, P Paris, C Passerieux, J Pellerin, J Perlbarg, S Perron, A Petit, F Petitjean, C Portefaix, D Pringuey, A Radtchenko, H Rahiou, D Raucher-Chéné, A Rauzy, L Reinheimer, M Renard, M René, CE Rengade, P Reynaud, D Robin, C Rodrigues, A Rollet, F Rondepierre, B Rousselot, S Rubingher, G Saba, JP Salvarelli, JC Samuelian, C Scemama-Ammar, F Schurhoff, JP Schuster, D Sechter, B Segalas, T Seguret, AS Seigneurie, A Semmak, F Slama, S Taisne, M Taleb, JL Terra, D Thefenne, E Tran, R Tourtauchaux, MN Vacheron, P Vandel, V Vanhoucke, E Venet, H Verdoux, A Viala, G Vidon, M Vitre, JL Vurpas, C Wagermez, M Walter, L Yon, X. Zendjidjian, Service de psychiatrie [Le Kremlin-Bicêtre], Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, Centre Hospitalier le Vinatier [Bron], Institut de psychiatrie et neurosciences (U894 / UMS 1266), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), PELLENC S.A., Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) (FEMTO-ST), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Laboratoire d'Informatique Fondamentale de Lille (LIFL), Université de Lille, Sciences et Technologies-Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lille, Sciences Humaines et Sociales-Centre National de la Recherche Scientifique (CNRS), Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques (GPMCND), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), French Society for Biological Psychiatry and Neuropsychopharmacology, Partenaires INRAE, Centre interuniversitaire de recherche et d'ingenierie des matériaux (CIRIMAT), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT), Département d'Astrophysique (ex SAP) (DAP), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Università degli studi di Genova = University of Genoa (UniGe), Fondation FondaMental [Créteil], Fédération Française de Triathlon (FFTRI), Institut de génétique humaine (IGH), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Cognition, Santé, Société (C2S), Université de Reims Champagne-Ardenne (URCA)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Reims Champagne-Ardenne (URCA)-Maison des Sciences Humaines de Champagne-Ardenne (MSH-URCA), Université de Reims Champagne-Ardenne (URCA), Laboratoire de Neurosciences Intégratives et Cliniques - UFC (UR 481) (NEURO), Université de Franche-Comté (UFC), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service hospitalo-universitaire, centre hospitalier du Rouvray, 4, rue Paul-Eluard, 76300 Sotteville-lès-Rouen, France., CHRU Brest - Psychiatrie Adulte (CHU - Brest- Psychiatrie), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Centre de Physique Théorique [Palaiseau] (CPHT), École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Centres d'addictologies - Région Centre, CHU Clermont-Ferrand, Unité de recherche clinique 93G03, établissement public de santé de Ville Evrard, 93330 Neuilly-sur-Marne, France., Laboratoire de Physique des Lasers (LPL), Université Paris 13 (UP13)-Centre National de la Recherche Scientifique (CNRS), Université Montpellier 1 (UM1), CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Sonatrach Exploration, Monash University [Clayton], Centre de Recherche en Sciences et Technologies de l'Information et de la Communication - EA 3804 (CRESTIC), Clinique de Psychiatrie et de Psychologie Médicale, Hôpital Pasteur, Nice, France, Centre Hospitalier Universitaire de Nice (CHU Nice), Department of Engineering Cybernetics [Trondheim] (ITK NTNU), Norwegian University of Science and Technology [Trondheim] (NTNU), Norwegian University of Science and Technology (NTNU)-Norwegian University of Science and Technology (NTNU), Jeune Equipe Hémopathogènes Vectorisés, VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS), Silicon-on-Insulator Technologies (SOITEC), Parc Technologique des Fontaines, Recherches en Psychopathologie, nouveaux symptômes et lien social (EA 4050), Université de Poitiers-Université de Brest (UBO)-Université Catholique de l'Ouest (UCO)-Université de Rennes 2 (UR2), Agriculture et forêt méditerranéenne (UR AFAX), Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF), Kantar – Health Division, Institut National de Recherche en Génie Rural Eaux et Forêts (INRGREF), Ecole Nationale du Génie Rural, des Eaux et des Forêts (ENGREF)-Institution de la Recherche et de l'Enseignement Supérieur Agricoles [Tunis] (IRESA), Département de psychiatrie [CHRU de Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Institut de biologie et chimie des protéines [Lyon] (IBCP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Pôle Universitaire de Psychiatrie Adulte, Différenciation et communication neuronale et neuroendocrine (DC2N), Centre de Psychiatrie et Neurosciences (U894), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC), Dipartimento di Scienze della Terra, Universita degli studi di Genova, Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Maison des Sciences Humaines de Champagne-Ardenne (MSH-URCA), Laboratoire de Neurosciences Intégratives et Cliniques - UFC (EA 481) (NEURO), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Centre National de la Recherche Scientifique (CNRS)-Université de Technologie de Belfort-Montbeliard (UTBM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), and Université Fédérale Toulouse Midi-Pyrénées

Subjects
Male, Aging, medicine.medical_specialty, Bipolar Disorder, Lithium (medication), Population, [SHS.PSY]Humanities and Social Sciences/Psychology, Comorbidity, [SHS]Humanities and Social Sciences, law.invention, Benzodiazepines, Depressive Disorder, Treatment-Resistant, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, medicine, Humans, Bipolar disorder, education, Psychiatry, ComputingMilieux_MISCELLANEOUS, Aged, Depressive Disorder, Major, education.field_of_study, Depression, business.industry, Middle Aged, medicine.disease, Antidepressive Agents, 3. Good health, 030227 psychiatry, Hospitalization, Psychiatry and Mental health, Clinical Psychology, Cross-Sectional Studies, Mood disorders, Tolerability, Schizophrenia, Lithium Compounds, Major depressive disorder, Female, business, 030217 neurology & neurosurgery, Antipsychotic Agents, medicine.drug
Abstract

Although lithium is widely used in current practice to treat bipolar disorder (BD) and treatment-resistant major depressive disorder (MDD) among older adults, little is known about its efficacy and tolerability in this population, which is generally excluded from randomized clinical trials. The objective of this study was to evaluate the efficacy and tolerability of long-term use of lithium among older adults with BD and MDD.Data from the Cohort of individuals with Schizophrenia and mood disorders Aged 55 years or more (CSA) were used. Two groups of patients with BD and MDD were compared: those who were currently receiving lithium versus those who were not. The effects of lithium on psychiatric (i.e., depressive symptoms severity, perceived clinical severity, rates of psychiatric admissions in the past-year), geriatric (overall and cognitive functioning) and physical outcomes (i.e., rates of non-psychiatric medical comorbidities and general hospital admissions in the past-year) were evaluated. All analyses were adjusted for age, sex, duration of disorder, diagnosis, smoking status, alcohol use, and use of antipsychotics, antiepileptics or antidepressants.Among the 281 older participants with BD or MDD, 15.7% were taking lithium for a mean duration of 12.5(SD = 11.6) years. Lithium use was associated with lower intensity of depressive symptoms, reduced perceived clinical global severity and lower benzodiazepine use (all p 0.05), without being linked to greater rates of medical comorbidities, except for hypothyroidism.Data were cross-sectional and data on lifetime history of psychotropic medications was not assessed.Our results suggest that long-term lithium use may be efficient and relatively well-tolerated in older adults with BD or treatment-resistant MDD.

Published
2019

5. Self-reported mental health symptoms, quality of life and coping strategies in French health sciences students during the early stage of the COVID-19 pandemic: An online survey

Author

Edouard Leaune, M. Marchal, S. Crandall, M. Vieux, Julie Haesebaert, Emmanuel Poulet, and C. Combes

Subjects
Coping (psychology), Population, Context (language use), Anxiety, Quality of life (healthcare), Arts and Humanities (miscellaneous), Surveys and Questionnaires, Adaptation, Psychological, medicine, Humans, education, Students, Suicidal ideation, Pandemics, education.field_of_study, SARS-CoV-2, Depression, Beck Depression Inventory, COVID-19, Mental health, Psychiatry and Mental health, Mental Health, Communicable Disease Control, Quality of Life, Female, Self Report, medicine.symptom, Psychology, Stress, Psychological, Clinical psychology
Abstract

Introduction Health sciences students usually report high rates of mental health problems. The COVID-19 pandemic context may have serious psychological impacts in this at-risk population. We aimed to assess the self-reported mental health status, health-related quality of life and coping strategies of health sciences students during the early stage of the pandemic. Method An online 128-item questionnaire sent to 17,673 health sciences students from the Claude Bernard University Lyon 1 in April 2020 assessed: a) sociodemographic characteristics, b) conditions of lockdown, c) depressive (Beck Depression Inventory- Short Form, BDI-SF), anxiety (State-Trait Anxiety Inventory-A, STAI-A) and traumatic symptoms (Impact of Event Scale -Revised, IES-R), d) health-related quality of life (SF12) and e) coping strategies (Brief Coping Orientation to Problems Experienced, Brief COPE). Results The participation rate was 9.9% (n = 1,765). A total of 19.5% of participants reported an IES-R > 33, 11.6% depressive symptoms, 58.1% anxiety symptoms, and 4.4% suicidal ideation. Their mental health-related quality of life was significantly poorer than for physical health. Female gender, COVID-like symptoms, social isolation due to the lockdown, pandemic-related financial restraint and exams-related stress were significantly associated with poorer self-reported mental health conditions. Volunteering in the healthcare system was significantly associated with lower mental health scores. Coping strategies were mostly oriented toward avoidance and positive appraisal. Conclusion French health sciences students exhibited high levels of self-reported mental health problems and a poor mental health-related quality of life during the early stage of the COVID-19 pandemic. Specific risk factors related to the pandemic partly explain the observed prevalence.

Published
2021

6. Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

Author

Bastard, P. Gervais, A. Voyer, T.L. Rosain, J. Philippot, Q. Manry, J. Michailidis, E. Hoffmann, H.-H. Eto, S. Garcia-Prat, M. Bizien, L. Parra-Martínez, A. Yang, R. Haljasmägi, L. Migaud, M. Särekannu, K. Maslovskaja, J. De Prost, N. Tandjaoui-Lambiotte, Y. Luyt, C.-E. Amador-Borrero, B. Gaudet, A. Poissy, J. Morel, P. Richard, P. Cognasse, F. Troya, J. Trouillet-Assant, S. Belot, A. Saker, K. Garçon, P. Rivière, J.G. Lagier, J.-C. Gentile, S. Rosen, L.B. Shaw, E. Morio, T. Tanaka, J. Dalmau, D. Tharaux, P.-L. Sene, D. Stepanian, A. Megarbane, B. Triantafyllia, V. Fekkar, A. Heath, J.R. Franco, J.L. Anaya, J.-M. Solé-Violán, J. Imberti, L. Biondi, A. Bonfanti, P. Castagnoli, R. Delmonte, O.M. Zhang, Y. Snow, A.L. Holland, S.M. Biggs, C.M. Moncada-Vélez, M. Arias, A.A. Lorenzo, L. Boucherit, S. Coulibaly, B. Anglicheau, D. Planas, A.M. Haerynck, F. Duvlis, S. Nussbaum, R.L. Ozcelik, T. Keles, S. Bousfiha, A.A. El Bakkouri, J. Ramirez-Santana, C. Paul, S. Pan-Hammarström, Q. Hammarström, L. Dupont, A. Kurolap, A. Metz, C.N. Aiuti, A. Casari, G. Lampasona, V. Ciceri, F. Barreiros, L.A. Dominguez-Garrido, E. Vidigal, M. Zatz, M. Van De Beek, D. Sahanic, S. Tancevski, I. Stepanovskyy, Y. Boyarchuk, O. Nukui, Y. Tsumura, M. Vidaur, L. Tangye, S.G. Burrel, S. Duffy, D. Quintana-Murci, L. Klocperk, A. Kann, N.Y. Shcherbina, A. Lau, Y.-L. Leung, D. Coulongeat, M. Marlet, J. Koning, R. Reyes, L.F. Chauvineau-Grenier, A. Venet, F. Monneret, G. Nussenzweig, M.C. Arrestier, R. Boudhabhay, I. Baris-Feldman, H. Hagin, D. Wauters, J. Meyts, I. Dyer, A.H. Kennelly, S.P. Bourke, N.M. Halwani, R. Sharif-Askari, N.S. Dorgham, K. Sallette, J. Sedkaoui, S.M. AlKhater, S. Rigo-Bonnin, R. Morandeira, F. Roussel, L. Vinh, D.C. Ostrowski, S.R. Condino-Neto, A. Prando, C. Bondarenko, A. Spaan, A.N. Gilardin, L. Fellay, J. Lyonnet, S. Bilguvar, K. Lifton, R.P. Mane, S. Anderson, M.S. Boisson, B. Béziat, V. Zhang, S.-Y. Andreakos, E. Hermine, O. Pujol, A. Peterson, P. Mogensen, T.H. Rowen, L. Mond, J. Debette, S. De Lamballerie, X. Duval, X. Mentré, F. Zins, M. Soler-Palacin, P. Colobran, R. Gorochov, G. Solanich, X. Susen, S. Martinez-Picado, J. Raoult, D. Vasse, M. Gregersen, P.K. Piemonti, L. Rodríguez-Gallego, C. Notarangelo, L.D. Su, H.C. Kisand, K. Okada, S. Puel, A. Jouanguy, E. Rice, C.M. Tiberghien, P. Zhang, Q. Cobat, A. Abel, L. Casanova, J.-L. Alavoine, L. Behillil, S. Burdet, C. Charpentier, C. Dechanet, A. Descamps, D. Ecobichon, J.-L. Enouf, V. Frezouls, W. Houhou, N. Kafif, O. Lehacaut, J. Letrou, S. Lina, B. Lucet, J.-C. Manchon, P. Nouroudine, M. Piquard, V. Quintin, C. Thy, M. Tubiana, S. Van Der Werf, S. Vignali, V. Visseaux, B. Yazdanpanah, Y. Chahine, A. Waucquier, N. Migaud, M.-C. Deplanque, D. Djossou, F. Mergeay-Fabre, M. Lucarelli, A. Demar, M. Bruneau, L. Gerardin, P. Maillot, A. Payet, C. Laviolle, B. Laine, F. Paris, C. Desille-Dugast, M. Fouchard, J. Malvy, D. Nguyen, D. Pistone, T. Perreau, P. Gissot, V. Le Goas, C. Montagne, S. Richard, L. Chirouze, C. Bouiller, K. Desmarets, M. Meunier, A. Lefevre, B. Jeulin, H. Legrand, K. Lomazzi, S. Tardy, B. Gagneux-Brunon, A. Bertholon, F. Botelho-Nevers, E. Christelle, K. Nicolas, L. Roufai, L. Amat, K. Couffin-Cadiergues, S. Esperou, H. Hendou, S. Townsend, L. Cheallaigh, C.N. Bergin, C. Martin-Loeches, I. Dunne, J. Conlon, N. O'Farrelly, C. Abad, J. Accordino, G. Achille, C. Aguilera-Albesa, S. Aguilo-Cucurull, A. Ozkan, E.A. Darazam, I.A. Albisures, J.A.R. Aldave, J.C. Ramos, M.A. Khan, T.A. Aliberti, A. Nadji, S.A. Alkan, G. AlKhater, S.A. Allardet-Servent, J. Allende, L.M. Alonso-Arias, R. Alshahrani, M.S. Alsina, L. Alyanakian, M.-A. Borrero, B.A. Amoura, Z. Antoli, A. Aubart, M. Auguet, T. Avramenko, I. Aytekin, G. Azot, A. Bahram, S. Bajolle, F. Baldanti, F. Baldolli, A. Ballester, M. Feldman, H.B. Barrou, B. Barzaghi, F. Basso, S. Bayhan, G.I. Bezrodnik, L. Bilbao, A. Blanchard-Rohner, G. Blanco, I. Blandinieres, A. Blazquez-Gamero, D. Bleibtreu, A. Bloomfield, M. Bolivar-Prados, M. Borghesi, A. Borie, R. Botdhlo-Nevers, E. Bousquet, A. Boutolleau, D. Bouvattier, C. Bravais, J. Briones, M.L. Brunner, M.-E. Bruno, R. Bueno, M.R.P. Bukhari, H. Bustamante, J. Agra, J.J.C. Capra, R. Carapito, R. Carrabba, M. Casasnovas, C. Caseris, M. Cassaniti, I. Castelle, M. Castelli, F. De Vera, M.C. Castro, M.V. Catherinot, E. Celik, J.B. Ceschi, A. Chalumeau, M. Charbit, B. Cheng, M.P. Clave, P. Clotet, B. Codina, A. Cohen, Y. Comarmond, C. Combes, A. Comoli, P. Corsico, A.G. Coşkuner, T. Cvetkovski, A. Cyrus, C. Danion, F. Darley, D.R. Das, V. Dauby, N. Dauger, S. De Munter, P. De Pontual, L. Dehban, A. Delplancq, G. Demoule, A. Desguerre, I. Di Sabatino, A. Diehl, J.-L. Dobbelaere, S. Dubost, C. Ekwall, O. Bozdemir, Ş.E. Elnagdy, M.H. Emiroglu, M. Endo, A. Erdeniz, E.H. Aytekin, S.E. Lasa, M.P.E. Euvrard, R. Fabio, G. Faivre, L. Falck, A. Fartoukh, M. Faure, M. Arquero, M.F. Ferrer, R. Ferreres, J. Flores, C. Francois, B. Fumado, V. Fung, K.S.C. Fusco, F. Gagro, A. Solis, B.G. Gaussem, P. Gayretli, Z. Gil-Herrera, J. Gatineau, A.G. Girona-Alarcon, M. Godinez, K.A.C. Goffard, J.-C. Gonzales, N. Gonzalez-Granado, L.I. Gonzalez-Montelongo, R. Guerder, A. Gulhan, B. Gumucio, V.D. Hanitsch, L.G. Gunst, J. Gut, M. Hadjadj, J. Hancerli, S. Hariyan, T. Hatipoglu, N. Heppekcan, D. Hernandez-Brito, E. Ho, P.-K. Holanda-Pena, M.S. Horcajada, J.P. Hraiech, S. Humbert, L. Hung, I.F.N. Iglesias, A.D. Inigo-Campos, A. Jamme, M. Arranz, M.J. Jimeno, M.-T. Jordan, I. Kanik-Yuksek, S. Kara, Y.B. Karahan, A. Karbuz, A. Yasar, K.K. Kasapcopur, O. Kashimada, K. Demirkol, Y.K. Kido, Y. Kizil, C. Kilic, A.O. Koutsoukou, A. Krol, Z.J. Ksouri, H. Kuentz, P. Kwan, A.M.C. Kwan, Y.W.M. Kwok, J.S.Y. Lam, D.S.Y. Lampropoulou, V. Lanternier, F. Le Bourgeois, F. Leo, Y.-S. Lopez, R.L. Levin, M. Levy, M. Levy, R. Li, Z. Lilleri, D. Lima, E.J.A.B. Linglart, A. Lopez-Collazo, E. Lorenzo-Salazar, J.M. Louapre, C. Lubetzki, C. Lung, K.-C. Lye, D.C. Magnone, C. Mansouri, D. Marchioni, E. Marioli, C. Marjani, M. Marques, L. Pereira, J.M. Martin-Nalda, A. Pueyo, D.M. Marzana, I. Mata-Martinez, C. Mathian, A. Matos, L.R.B. Matthews, G.V. Mayaux, J. McLaughlin-Garcia, R. Meersseman, P. Mege, J.-L. Mekontso-Dessap, A. Melki, I. Meloni, F. Meritet, J.-F. Merlani, P. Akcan, O.M. Mezidi, M. Migeotte, I. Millereux, M. Million, M. Mirault, T. Mircher, C. Mirsaeidi, M. Mizoguchi, Y. Modi, B.P. Mojoli, F. Moncomble, E. Melian, A.M. Martinez, A.M. Morange, P.-E. Mordacq, C. Morelle, G. Mouly, S.J. Munoz-Barrera, A. Nafati, C. Nagashima, S. Nakagama, Y. Neven, B. Neves, J.F. Ng, L.F.P. Ng, Y.-Y. Nielly, H. Medina, Y.N. Cuadros, E.N. Ocejo-Vinyals, J.G. Okamoto, K. Oualha, M. Ouedrani, A. Ozkaya-Parlakay, A. Pagani, M. Papadaki, M. Parizot, C. Parola, P. Pascreau, T. Paz-Artal, E. Pedraza, S. Pellecer, N.C.G. Pellegrini, S. De Diego, R.P. Perez-Fernandez, X.L. Philippe, A. Picod, A. De Chambrun, M.P. Piralla, A. Planas-Serra, L. Ploin, D. Poncelet, G. Poulakou, G. Pouletty, M.S. Pourshahnazari, P. Qiu-Chen, J.L. Quentric, P. Rambaud, T. Raoult, V. Rebillat, A.-S. Redin, C. Resmini, L. Ricart, P. Richard, J.-C. Rivet, N. Rocamora-Blanch, G. Rodero, M.P. Rodrigo, C. Rodriguez, L.A. Rodriguez-Palmero, A. Romero, C.S. Rothenbuhler, A. Roux, D. Rovina, N. Rozenberg, F. Ruch, Y. Ruiz, M. Del Prado, M.Y.R. Ruiz-Rodriguez, J.C. Sabater-Riera, J. Saks, K. Salagianni, M. Sanchez, O. Sanchez-Montalva, A. Sanchez-Ramon, S. Schidlowski, L. Schluter, A. Schmidt, J. Schmidt, M. Schuetz, C. Schweitzer, C.E. Scolari, F. Sediva, A. Seijo, L. Seminario, A.G. Seng, P. Senoglu, S. Seppanen, M. Llovich, A.S. Shahrooei, M. Siguret, V. Siouti, E. Smadja, D.M. Smith, N. Sobh, A. Soler, C. Sozeri, B. Stella, G.M. Stepanovskiy, Y. Stoclin, A. Taccone, F. Taupin, J.-L. Tavernier, S.J. Terrier, B. Thiery, G. Thorball, C. Thorn, K. Thumerelle, C. Tipu, I. Tolstrup, M. Tomasoni, G. Toubiana, J. Alvarez, J.T. Tsang, O.T.Y. Tserel, L. Tso, E.Y.K. Tucci, A. Oz, Ş.K.T. Ursini, M.V. Utsumi, T. Uzunhan, Y. Vabres, P. Valencia-Ramos, J. Van Den Rym, A.M. Vandernoot, I. Velez-Santamaria, V. Veliz, S.P.Z. Vidigal, M.C. Viel, S. Vilain, C. Vilaire-Meunier, M.E. Villar-Garcia, J. Vincent, A. Vogt, G. Voiriot, G. Volokha, A. Vuotto, F. Wauters, E. Wu, A.K.L. Wu, T.-C. Yahşi, A. Yesilbas, O. Yildiz, M. Young, B.E. Yukselmiş, U. Zecca, M. Zuccaro, V. Van Praet, J. Lambrecht, B.N. Van Braeckel, E. Bosteels, C. Hoste, L. Hoste, E. Bauters, F. De Clercq, J. Heijmans, C. Slabbynck, H. Naesens, L. Florkin, B. Boulanger, C. Vanderlinden, D. Allavena, C. Andrejak, C. Angoulvant, F. Azoulay, C. Bachelet, D. Bartoli, M. Basmaci, R. Behillill, S. Beluze, M. Benech, N. Benkerrou, D. Bhavsar, K. Bitker, L. Bouadma, L. Bouscambert-Duchamp, M. Paz, P.C. Cervantes-Gonzalez, M. Chair, A. Coelho, A. Cordel, H. Couffignal, C. D'Ortenzio, E. De Montmollin, E. Debard, A. Debray, M.-P. Desvallee, M. Diallo, A. Diouf, A. Dorival, C. Dubos, F. Eloy, P. Epaulard, O. Esposito-Farase, M. Etienne, M. Garot, D. Gault, N. Gaymard, A. Ghosn, J. Gigante, T. Gilg, M. Goehringer, F. Guedj, J. Hoctin, A. Hoffmann, I. Houas, I. Hulot, J.-S. Jaafoura, S. Kaguelidou, F. Kali, S. Kerroumi, Y. Khalil, A. Khan, C. Kimmoun, A. Laouenan, C. Laribi, S. Le, M. Le Bris, C. Le Gac, S. Le Hingrat, Q. Le Mestre, S. Le Nagard, H. Lemaignen, A. Lemee, V. Lescure, F.-X. Levy, Y. Lingas, G. Lucet, J.C. MacHado, M. Mambert, M. Manuel, A. Meziane, A. Mouquet, H. Mullaert, J. Neant, N. Noret, M. Papadopoulos, A. Paul, C. Peiffer-Smadja, N. Peigne, V. Petrov-Sanchez, V. Peytavin, G. Pham, H. Picone, O. Puechal, O. Rosa-Calatrava, M. Rossignol, B. Rossignol, P. Roy, C. Schneider, M. Su, R. Tardivon, C. Tellier, M.-C. Teoule, F. Terrier, O. Timsit, J.F. Tual, C. Vanel, N. Veislinger, A. Wiedemann, A. Danielson, J.J. Dobbs, K. Kashyap, A. Ding, L. Dalgard, C.L. Sottini, A. Quaresima, V. Quiros-Roldan, E. Rossi, C. Bettini, L.R. D'Angio, M. Beretta, I. Montagna, D. Licari, A. Marseglia, G.L. Storgaard, M. Jorgensen, S. Al-Muhsen, S. Al-Mulla, F. Arias, A.A. Bogunovic, D. Bolze, A. Brodin, P. Bryceson, Y. Bustamante, C.D. Butte, M.J. Chakravorty, S. Christodoulou, J. Constantinescu, S.N. Cooper, M.A. Desai, M. Drolet, B.A. El Baghdadi, J. Espinosa-Padilla, S. Froidure, A. Henrickson, S.E. Hsieh, E.W.Y. Husebye, E.S. Imai, K. Itan, Y. Jarvis, E.D. Karamitros, T. Ku, C.-L. Ling, Y. Lucas, C.L. Maniatis, T. Marodi, L. Milner, J.D. Mironska, K. Novelli, A. Novelli, G. Renia, L. Resnick, I. Sancho-Shimizu, V. Seppanen, M.R.J. Shahrooei, M. Slaby, O. Tayoun, A.A. Ramaswamy, S. Turvey, S.E. Furkan Uddin, K.M. Uddin, M.J. Von Bernuth, H. Zawadzki, P. Bigio, B. De La Chapelle, A. Chen, J. Chrabieh, M. Liu, D. Nemirowskaya, Y. Cruz, I.M. Materna, M. Pelet, S. Seeleuthner, Y. Thibault, C. Liu, Z. Foti, G. Bellani, G. Citerio, G. Contro, E. Pesci, A. Valsecchi, M.G. Cazzaniga, M. Batten, I. Reddy, C. McElheron, M. Noonan, C. Connolly, E. Fallon, A. Erikstrup, C. Pedersen, O.B. Sorensen, E. Mikkelsen, S. Dinh, K.M. Larsen, M.A.H. Paulsen, I.W. Von Stemann, J.H. Hansen, M.B. Annereau, J.-P. Briseno-Roa, L. Gribouval, O. Pelet, A. Alcover, A. Aschard, H. Bousso, P. Bruhns, P. Cerf-Bensussan, N. Cumano, A. D'Enfert, C. Deriano, L. Dillies, M.-A. Di Santo, J. Dromer, F. Eberl, G. Enninga, J. Gomperts-Boneca, I. Hasan, M. Hedestam, G.K. Hercberg, S. Ingersoll, M.A. Lantz, O. Kenny, R.A. Menager, M. Michel, F. Patin, E. Pellegrini, S. Rausell, A. Rieux-Laucat, F. Rogge, L. Fontes, M. Sakuntabhai, A. Schwartz, O. Schwikowski, B. Shorte, S. Tangy, F. Toubert, A. Touvier, M. Ungeheuer, M.-N. Zimmer, C. Albert, M.L. Van Agtmael, M. Algera, A.G. Appelman, B. Van Baarle, F. Bax, D. Beudel, M. Bogaard, H.J. Bomers, M. Bonta, P. Bos, L. Botta, M. De Brabander, J. De Bree, G. De Bruin, S. Buis, D.T.P. Bugiani, M. Bulle, E. Chouchane, O. Cloherty, A. Dijkstra, M. Dongelmans, D.A. Dujardin, R.W.G. Elbers, P. Fleuren, L. Geerlings, S. Geijtenbeek, T. Girbes, A. Goorhuis, B. Grobusch, M.P. Hafkamp, F. Hagens, L. Hamann, J. Harris, V. Hemke, R. Hermans, S.M. Heunks, L. Hollmann, M. Horn, J. Hovius, J.W. De Jong, M.D. Lim, E.H.T. Van Mourik, N. Nellen, J. Nossent, E.J. Paulus, F. Peters, E. Pina-Fuentes, D.A.I. Van Der Poll, T. Preckel, B. Prins, J.M. Raasveld, J. Reijnders, T. De Rotte, M.C.F.J. Schinkel, M. Schultz, M.J. Schrauwen, F.A.P. Schuurman, A. Schuurmans, J. Sigaloff, K. Slim, M.A. Smeele, P. Smit, M. Stijnis, C.S. Stilma, W. Teunissen, C. Thoral, P. Tsonas, A.M. Tuinman, P.R. Van Der Valk, M. Veelo, D. Volleman, C. De Vries, H. Vught, L.A. Van Vugt, M. Wouters, D. Zwinderman, A.H. Brouwer, M.C. Joost Wiersinga, W. Vlaar, A.P.J. Nadif, R. Goldberg, M. Ozguler, A. Henny, J. Lemonnier, S. Coeuret-Pellicer, M. Le Got, S. Tzourio, C. Dufouil, C. Soumare, A. Lachaize, M. Fievet, N. Flaig, A. Martin, F. Bonneaudeau, B. Cannet, D. Gallian, P. Jeanne, M. Perroquin, M. Hamzeh-Cognasse, H. CoV-Contact Cohort St James's Hospital, SARS CoV2 Interest group COVID Clinicians French COVID Cohort Study Group NIAID Immune Response to COVID Group Danish CHGE COVID Human Genetic Effort HGID Lab COVID-STORM Clinicians NH-COVAIR Study Group The Danish Blood Donor Study (DBDS) Imagine COVID-Group The Milieu Interieur Consortium Amsterdam UMC Covid-19 Biobank CONSTANCES cohort 3C-Dijon Study Cerba HealthCare Etablissement du Sang study group

Abstract

Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/ml; in plasma diluted 1:10) of IFN-α and/or IFN-ω are found in about 10% of patients with critical COVID-19 (coronavirus disease 2019) pneumonia but not in individuals with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-α and/or IFN-ω (100 pg/ml; in 1:10 dilutions of plasma) in 13.6% of 3595 patients with critical COVID-19, including 21% of 374 patients >80 years, and 6.5% of 522 patients with severe COVID-19. These antibodies are also detected in 18% of the 1124 deceased patients (aged 20 days to 99 years; mean: 70 years). Moreover, another 1.3% of patients with critical COVID-19 and 0.9% of the deceased patients have auto-Abs neutralizing high concentrations of IFN-β. We also show, in a sample of 34,159 uninfected individuals from the general population, that auto-Abs neutralizing high concentrations of IFN-α and/or IFN-ω are present in 0.18% of individuals between 18 and 69 years, 1.1% between 70 and 79 years, and 3.4% >80 years. Moreover, the proportion of individuals carrying auto-Abs neutralizing lower concentrations is greater in a subsample of 10,778 uninfected individuals: 1% of individuals 80 years. By contrast, auto-Abs neutralizing IFN-β do not become more frequent with age. Auto-Abs neutralizing type I IFNs predate SARS-CoV-2 infection and sharply increase in prevalence after the age of 70 years. They account for about 20% of both critical COVID-19 cases in the over 80s and total fatal COVID-19 cases. © 2021 The Authors, some rights reserved.

Published
2021

7. Modalités de prise en charge des morts inattendues du nourrisson à l’Institut médico-légal et au Centre de référence pour la mort inattendue du nourrisson du CHU de Montpellier et comparaison aux recommandations professionnelles

Author

Eric Baccino, G. Cambonie, C. Combes, M. Lossois, Pierre-Antoine Peyron, and O. Pidoux

Subjects
03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Pathology and Forensic Medicine
Abstract

Resume Introduction La mort inattendue du nourrisson (MIN) est un probleme notable de sante publique ayant fait l’objet de recommandations professionnelles en 2007. L’objectif principal est d’etudier les modalites de prise en charge des MIN a l’Institut medico-legal (IML) et au Centre de reference pour la mort inattendue du nourrisson (CRMIN) de Montpellier et de les comparer aux recommandations. Materiels et methodes Nous avons realise une etude retrospective des MIN prises en charge au CHRU de Montpellier entre janvier 2011 et decembre 2013. Les modalites de prise en charge des deux services ont ete comparees aux recommandations. Resultats Quarante-deux dossiers ont ete inclus (âge median = 9 semaines (0 ; 85) ; sex-ratio = 70 %). Le fond d’œil n’est jamais realise, l’imagerie cerebrale est pratiquee dans 47 % a l’IML et 81 % au CRMIN. A l’IML, les prelevements infectieux sont deux fois moins effectues et les prelevements bacteriologiques, toxicologiques, et histologiques ne sont pas analyses dans trois quarts des cas. Une transmission du dossier a lieu dans 17 % des cas et une cause de deces est trouvee dans respectivement 47 % et 68 % des dossiers. Discussion L’imagerie cerebrale, les prelevements infectieux, et l’analyse des prelevements doivent devenir systematiques a l’IML. Une transmission du dossier au CRMIN est preconisee quand la cause du deces n’est pas identifiee au terme des investigations medico-legales. Conclusion Une prise en charge optimale des MIN necessite une meilleure prise en compte des recommandations actuelles. Une collaboration etroite entre l’IML et le CRMIN et une sensibilisation des magistrats sont indispensables.

Published
2017

8. Comparative allometry growth of some marine fish digenetic trematodes

Author

A. Saad-Fares and C. Combes

Subjects
allometry growth, marine fish, digenetic trematodes, Microbiology, QR1-502, Infectious and parasitic diseases, RC109-216
Abstract

Allometric growth variation was compared for Plagioporus idoneus, Lepocreadium pegorchis, Opecoeloides furcatus, Bacciger israelensis, Aphanurus stossichi and Parahurleytrema trachinoti collected from East Mediterranean fishes. The pharynx, the oral and the ventral sucker diameters always showed a negative allometry. The other parameters tested were variable with the species. We study the effects of some environmental factors: the influence of the host species is analysed in Plagioporus idoneous, wich parasitizes Oblada melanura, Diplodus sargus and D. vulgaris and in Lepocreadium pegorchis, wich parasitizes Pagellus erythrinus, Lithognathus mormyrus and Spicara smaris; the influence of the microhabitat and the intensity of infection is analysed in Bacciger israelensis and Aphanurus stossichi, both parasites of Boops boops. We report significant differences with the host species, for the allometric growth of the testes; the effect of the microhabitat was revealed by the hindbody allometric value; no significant difference was detected in relation with the intensity of infection.

Published
1992
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9. Effects of depression and cognitive impairment on quality of life in older adults with schizophrenia spectrum disorder: Results from a multicenter study

Author

A. Brochard, F. Slama, B. Beaufils, O. Guillin, P. Reynaud, M Masson, E. Duprat, M. Miron, Christine Passerieux, A. Rollet, Isabelle Amado, R. Tourtauchaux, H. Hadaoui, A. Leydier, Vincent Camus, Pierre Lavaud, C.E. Rengade, V. Vanhoucke, Nicolas Hoertel, S. Lucas Navarro, Thomas Charpeaud, C. Rodrigues, L. Yon, J. Adès, E. Venet, M.N. Vacheron, V. Griner, Ghassen Saba, T. Bichet, M. Bareil-Guérin, F. Limosin, C. Hanon, Olivier Blanc, H. Gres, L. Mekaoui, J. Mauvieux, Emmanuel Haffen, A. Radtchenko, Frédéric Limosin, D. Arbault, C. Fernandez, B. Rousselot, I. Maurs-Ferrer, A. Mihoubi, A. Heron, E. Tran, R. Gourevitch, O. Maillet, P. Legrand, S. Rubingher, J. Gremion, Xavier Zendjidjian, F. Getten, A.S. Seigneurie, P. Fonfrede, C. Clad-Mor, N. Freitas, A.M. Bouysse, Dominique Januel, Marion Leboyer, P. Vandel, L. Reinheimer, F. Petitjean, A. Rauzy, V. Niro Adès, V. Lemaire, Fabien Gierski, D. Levy-Chavagnat, C. Guggiari, J.F. Karnycheff, M. Cabot, C. Omnes, M. Mahi, A. Grassin Delyle, Hélène Verdoux, D. Robin, Cédric Lemogne, E. Diers, P. Gasnier, J.L. Vurpas, D. Da Rin, Christine Cuervo-Lombard, F. Blanadet, C. Hazif-Thomas, D. Duthoit, Céline Béra-Potelle, J.M. Chabannes, B. Segalas, Hugo Peyre, Hélène Denizot, J.B. Denis, A. Viala, Didier Boussiron, A. Semmak, P. Martin, C. Lajugie, Sarah Barrière, G. Mora, C. Barrouillet, M. Meniai, Michel Walter, J. Ben Ayed, J.P. Salvarelli, K. Benyacoub, T. Seguret, D. Thefenne, M. Benoit, Isabelle Jalenques, B. Bucheron, S. Papin, B. Cordier, D. Pringuey, E. Baup, M. Renard, A. Deperthuis, S. Haouzir, Pierre-Michel Llorca, Y. Blumenstock, A. Dammak, Bérengère Hübsch, D. Donneau, D. Sechter, E. Mechin, Jean-Pierre Schuster, Yvonne Blumenstock, N. Mages, J.C. Samuelian, J.L. Terra, Carlos Blanco, C. Wagermez, H. Bardou, Christophe Guerin-Langlois, A. Petit, A. Kaladjian, J. Gauillard, M. Taleb, M. Creixell, C. Scemama-Ammar, P. Nubukpo, S. Mazmanian, M. Lejoyeux, J. Perlbarg, F. Schürhoff, O. Kebir, G. Amar, O. Brochart, Christophe Portefaix, Christine-Vanessa Cuervo-Lombard, F. Costi, Rachel Pascal de Raykeer, H. Rahiou, C. Alezrah, J.P. Courcelles, N. Bazin, Delphine Raucher-Chéné, J. Pellerin, H. Cuche, V. Charlot, P. Paris, E. Leroy, M. Comisu, M. René, C. Martelli, Arthur Kaladjian, G. Vidon, C. Combes, O. Andréi, A. Manetti, A. Metton, J. Blanc-Comiti, Caroline Dubertret, S. Taisne, S. Perron, M.O. Krebs, M. Vitre, G. Archambault, P. Barrau, S. Dirami, F. Rondepierre, F. Godart, P. Dreano, N. Hoertel, G. Aurifeuille, P. Loeffel, P. Louville, C. Liling, Université Paris Descartes - Paris 5 (UPD5), Centre d’Etudes et de Recherches en Psychopathologie et Psychologie de la Santé (CERPPS), Université Toulouse - Jean Jaurès (UT2J), Maladies neurodéveloppementales et neurovasculaires (NeuroDiderot (UMR_S_1141 / U1141)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Interactions cellulaires et moléculaires (ICM), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), Service psychiatrique de l'enfant et de l'adolescent [CHU Hôpital Robert Debré], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré, Institut de psychiatrie et neurosciences (U894 / UMS 1266), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), PELLENC S.A., Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) (FEMTO-ST), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Informatique Fondamentale de Lille (LIFL), Université de Lille, Sciences et Technologies-Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lille, Sciences Humaines et Sociales-Centre National de la Recherche Scientifique (CNRS), Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques (GPMCND), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), French Society for Biological Psychiatry and Neuropsychopharmacology, Partenaires INRAE, Centre interuniversitaire de recherche et d'ingenierie des matériaux (CIRIMAT), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées, Département d'Astrophysique (ex SAP) (DAP), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Dipartimento di Scienze della Terra, Universita degli studi di Genova, Unité de recherche Biométrie (UB), Institut National de la Recherche Agronomique (INRA), Fondation FondaMental [Créteil], Fédération Française de Triathlon (FFTRI), Institut de génétique humaine (IGH), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Cognition, Santé, Société (C2S), Université de Reims Champagne-Ardenne (URCA)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Maison des Sciences Humaines de Champagne-Ardenne (MSH-URCA), Université de Reims Champagne-Ardenne (URCA), Laboratoire de Neurosciences Intégratives et Cliniques - UFC (EA 481) (NEURO), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service hospitalo-universitaire, centre hospitalier du Rouvray, 4, rue Paul-Eluard, 76300 Sotteville-lès-Rouen, France., CHRU Brest - Psychiatrie Adulte (CHU - Brest- Psychiatrie), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Centre de Physique Théorique [Palaiseau] (CPHT), École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Centres d'addictologies - Région Centre, CHU Clermont-Ferrand, Unité de recherche clinique 93G03, établissement public de santé de Ville Evrard, 93330 Neuilly-sur-Marne, France., Service de Psychiatrie pour Adultes [CHU Reims], Centre Hospitalier Universitaire de Reims (CHU Reims), Université Montpellier 1 (UM1), CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux (NPsy-Sydo), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-CHU Clermont-Ferrand, Sonatrach Exploration, Monash University [Clayton], Centre de Recherche en Sciences et Technologies de l'Information et de la Communication - EA 3804 (CRESTIC), Clinique de Psychiatrie et de Psychologie Médicale, Hôpital Pasteur, Nice, France, Centre Hospitalier Universitaire de Nice (CHU Nice), Department of Engineering Cybernetics [Trondheim] (ITK NTNU), Norwegian University of Science and Technology [Trondheim] (NTNU), Norwegian University of Science and Technology (NTNU)-Norwegian University of Science and Technology (NTNU), Jeune Equipe Hémopathogènes Vectorisés, VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS), Silicon-on-Insulator Technologies (SOITEC), Parc Technologique des Fontaines, Recherches en Psychopathologie, nouveaux symptômes et lien social (EA 4050), Université de Poitiers-Université de Brest (UBO)-Université Catholique de l'Ouest (UCO)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Agriculture et forêt méditerranéenne (UR AFAX), Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF), Kantar – Health Division, Institut National de Recherche en Génie Rural Eaux et Forêts (INRGREF), Ecole Nationale du Génie Rural, des Eaux et des Forêts (ENGREF)-Institution de la Recherche et de l'Enseignement Supérieur Agricoles [Tunis] (IRESA), Département de psychiatrie [CHU de Besançon], Centre Hospitalier Régional Universitaire [Besançon] (CHRU Besançon), Institut de biologie et chimie des protéines [Lyon] (IBCP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Pôle Universitaire de Psychiatrie Adulte, Différenciation et communication neuronale et neuroendocrine (DC2N), and PHRC 2008-N11-01, Ministère des Affaires Sociales et de la Santé

Subjects
Male, Quality of life, Schizoaffective disorder, [SDV]Life Sciences [q-bio], [SHS.PSY]Humanities and Social Sciences/Psychology, Structural equation modeling, [SHS]Humanities and Social Sciences, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Cognition, Elderly, medicine, Humans, Cognitive Dysfunction, Depression (differential diagnoses), ComputingMilieux_MISCELLANEOUS, Aged, Aged, 80 and over, Psychiatric Status Rating Scales, business.industry, Depression, Middle Aged, medicine.disease, 3. Good health, 030227 psychiatry, Psychiatry and Mental health, Clinical Psychology, Cross-Sectional Studies, Schizophrenia, Older adults, Cohort, Female, Schizophrenic Psychology, business, 030217 neurology & neurosurgery, Clinical psychology, Schizophrenia spectrum
Abstract

Little is known about the respective effects of depression and cognitive impairment on quality of life among older adults with schizophrenia spectrum disorder.We used data from the Cohort of individuals with Schizophrenia Aged 55-years or more (CSA) study, a large multicenter sample of older adults with schizophrenia or schizoaffective disorder (N = 353). Quality of life (QoL), depression and cognitive impairment were assessed using the Quality of Life Scale (QLS), the Center of Epidemiologic Studies Depression scale and the Mini-Mental State Examination, respectively. We used structural equation modeling to examine the shared and specific effects of depression and cognitive impairment on QoL, while adjusting for sociodemographic characteristics, general medical conditions, psychotropic medications and the duration of the disorder.Depression and cognitive impairment were positively associated (r = 0.24, p 0.01) and both independently and negatively impacted on QoL (standardized β = -0.41 and β = -0.32, both p 0.01) and on each QLS quality-of-life domains, except for depression on instrumental role and cognitive impairment on interpersonal relations in the sensitivity analyses excluding respondents with any missing data. Effects of depression and cognitive impairment on QoL were not due to specific depressive symptoms or specific cognitive domains, but rather mediated through two broad dimensions representing the shared effects across all depressive symptoms and all cognitive deficits, respectively.Because of the cross-sectional design of this study, measures of association do not imply causal associations.Mechanisms underlying these two broad dimensions should be considered as important potential targets to improve quality of life of this vulnerable population.

Published
2019

11. Déchirure post-traumatique bilatérale des ischio-jambiers

Author

N. Barthes and C. Combes

Subjects
03 medical and health sciences, 0302 clinical medicine, Rehabilitation, Orthopedics and Sports Medicine, Surgery, 030229 sport sciences, 030218 nuclear medicine & medical imaging
Abstract

Resume Nous rapportons un cas de consultation pour hematome posterieur des deux cuisses survenu lors d’une seance d’entrainement au sprint chez un militaire de 35 ans, ancien athlete espoir. L’imagerie effectuee a revele une dechirure musculaire bilaterale non compliquee, prise en charge de maniere fonctionnelle associee a de la reeducation simple ; la reprise sportive a pu se faire au bout de 6 mois.

Published
2016

12. Anévrisme post-traumatique de l’artère temporale chez un jeune militaire

Author

C. Combes and N. Barthes

Subjects
03 medical and health sciences, 0302 clinical medicine, Rehabilitation, Orthopedics and Sports Medicine, Surgery, 030212 general & internal medicine, 030204 cardiovascular system & hematology
Abstract

Resume Nous rapportons un cas de tumefaction temporale peu douloureuse chez un jeune militaire ayant recu plusieurs coups au visage, une semaine auparavant, lors d’un entrainement au combat rapproche. Il s’agissait d’un anevrisme fusiforme de l’artere temporale superficielle gauche confirme par l’echo-Doppler. Le traitement, outre le repos sportif, a ete l’exclusion-exerese chirurgicale en service d’ORL. Les suites ont ete simples, avec une reprise des activites sportives a j7, sans sequelle.

Published
2016

13. [Anemia, a new severity factor in young infants with acute viral bronchiolitis?]

Author

G, Tourniaire, C, Milési, J, Baleine, J, Crozier, C, Lapeyre, C, Combes, N, Nagot, and G, Cambonie

Subjects
Hospitalization, Male, Hemoglobins, Logistic Models, Continuous Positive Airway Pressure, Infant, Newborn, Bronchiolitis, Viral, Humans, Infant, Anemia, Female, Severity of Illness Index, Retrospective Studies
Abstract

The role of anemia is raised as a risk of low respiratory infection of the child, but there are no data on anemia as a severity factor in acute viral bronchiolitis (AVB) in infants.All infants less than 16 weeks old admitted to Montpellier University Hospital from 2015/10/01 to 2016/04/01 for AVB were included in a retrospective observational study. The primary objective was to determine whether the hemoglobin (Hb) concentration on admission was an independent factor of clinical severity, judged by the modified Wood's clinical asthma score (m-WCAS). The secondary objective was to assess the impact of Hb level on the characteristics of hospitalization, including the type and duration of respiratory support.The m-WCAS was used at least once during hospitalization in 180 out of 220 patients (82%), making it possible to distinguish patients with mild AVB (maximum m-WCAS2, n=81) from patients with severe AVB (maximum m-WCAS2, n=99). A logistic regression model indicated that the Hb concentration, for every 1g/dL decrement, was an independent factor of AVB severity (OR 1.16 [1.03-1.29], P=0.026). A level under 10g/dL on admission was associated with a higher use of continuous positive airway pressure (P0.001), as well as a longer duration of respiratory support (P=0.01).This study suggested that anemia may influence the clinical expression of AVB in young infants.

Published
2016

15. Contributors

Author

J. An, A. Bigi, E. Boanini, F. Buchanan, C.A. Carrera, H. Cölfen, C. Combes, E. Cunningham, Timothy E.L. Douglas, N. Dunne, A. El-Fiqi, M. Gazzano, R.A. Giacaman, F.J. Gil Mur, L.B. Gower, J. Jansen, H.-W. Kim, T. Kokubo, S. Leeuwenburgh, I.B. Leonor, M. Navarro, R. Osorio, V.A. Perez, A. Rao, R.L. Reis, C. Rey, A.I. Rodrigues, P.A. Romero, S.-J. Seo, T. Serra, J. Seto, M. Toledano, G. Walker, J. Wolke, and S. Yamaguchi

Published
2016

16. Observance médicamenteuse et lieu de contrôle de la santé dans la schizophrénie

Author

C. Combes and F. Feral

Subjects
education.field_of_study, medicine.medical_treatment, Population, Compliance (psychology), Internal-External Control, Psychiatry and Mental health, Locus of control, Arts and Humanities (miscellaneous), Rating scale, Cognitive therapy, medicine, Medical prescription, Psychology, education, Clinical psychology, Rank correlation
Abstract

Schizophrenia is a frequent disorder since it affects about 1% of the general population. Drug compliance, that is to say patients' adherence to their treatment, remains rather poor concerning this disease with, on an average, one patient out of two not complying with his/her medication. Among the factors influencing drug compliance, we focused on patients' beliefs in terms of health control, a concept known as health locus of control. This is a concept that originated from social psychology and derived from the Rotters' original concept of locus of control: it corresponds to the type of connexion established by an individual between subsequent events in the history of his/her disease and internal (personal abilities) or external factors (chance, powerful others). Nowadays, the tridimensional structure of this concept is commonly admitted as being in three dimensions: internality, chance externality and powerful others externality, the latter group being divided between doctors and others. We have assumed that there is a correlation between the degree of drug compliance and the internal and/or doctors' external health locus of control. For this purpose, we have determined the quality of drug compliance by using the Medical Adherence Rating Scale (MARS) and the type of health locus of control by using the Multidimensional Health Locus of Control (MHLC) scale among 65 schizophrenic patients. We have also considered it was important to evaluate patients' insight by using the Amador's scale (Scale of Unawareness of Mental Disorder) because many researchers have established a strong correlation between insight and drug compliance in schizophrenia. Associations between the four dimensions of health locus of control ("internal", "chance external", "others external" and "doctors' external") and drug compliance were assessed by estimating Spearman's rank correlation coefficient (r) and its degree of significance (p). These associations were judged significant at an alpha threshold of 5%, which corresponded to a level of p inferior to 0.05. Our results tend to confirm a statistically significant positive correlation between internal (r=0.25; p=0.043) and/or doctors' external (r=0.27; p=0.027) health locus of control and drug compliance. Conversely, there is no correlation between chance external or others' external health locus of control and drug compliance (p>0.05). This means that the more patients believe that their schizophrenia can be controlled by themselves and/or by doctors, the more they follow their prescriptions. Furthermore, the link between health locus of control and drug compliance appears to be confused by two dimensions of insight, namely awareness of the response to the treatment and perceived need for treatment. An application of these results is that, in the case of patients whose health locus of control is chance or others' external, it can be beneficial to attempt to change their beliefs in order to improve drug compliance. These results hold particular interest in the field of psycho-education and can be directly applied to cognitive therapy for beliefs among stabilized schizophrenic patients.

Published
2011

17. Lymphome cérébral primitif de la tige pituitaire

Author

M. Berle, E. Alonso, C. Ajzenberg, C. Combes, Philippe Caillet, Elodie Taillandier-Heriche, Sébastien Krypciak, and Elena Paillaud

Subjects
Gastroenterology, Internal Medicine
Abstract

Resume Introduction Les tumeurs de la tige pituitaire sont rares et de diagnostic parfois difficile. Observation Nous rapportons une observation de lymphome primitif de la tige pituitaire chez une patiente de 78 ans. A notre connaissance, seuls sept cas similaires ont ete publies : les symptomes etaient domines par les cephalees, l’asthenie et la diplopie ; biologiquement, la majorite avait une atteinte antehypophysaire et/ou une hyperprolactinemie ; a l’imagerie, seuls trois patients avaient une atteinte initiale et isolee de la tige ; la preuve histologique etait apportee par une biopsie par voie trans-sphenoidale en cas de lesion hypophysaire ou hypothalamique associee ou par voie endocrânienne en cas de lesion isolee. Une alternative est la realisation d’une ponction lombaire, moins invasive mais moins rentable. Conclusion Le traitement actuel repose sur la chimiotherapie par methotrexate associee a du methotrexate intrathecal en cas de cytologie meningee positive. Malheureusement, les resultats restent decevants avec une mediane de survie a neuf mois.

Published
2010

18. 166 Helichrysum italicum essential oil prevents skin lipids peroxidation caused by pollution and UV

Author

Pascal Portes, M. Legrix, Valerie Cenizo, A. Moga, S. Grasset, V. Rouquet, S. Rivoire, and C. Combes

Subjects
0106 biological sciences, Pollution, biology, Chemistry, media_common.quotation_subject, 04 agricultural and veterinary sciences, Cell Biology, Dermatology, biology.organism_classification, 01 natural sciences, Biochemistry, Helichrysum italicum, law.invention, law, Botany, 040103 agronomy & agriculture, 0401 agriculture, forestry, and fisheries, Molecular Biology, Essential oil, 010606 plant biology & botany, media_common
Published
2017

19. Ram pressure stripping in the Virgo Cluster

Author

Verdugo, C. Combes, F. Dasyra, K. Salomé, P. Braine, J.

Subjects
Astrophysics::Solar and Stellar Astrophysics, Astrophysics::Earth and Planetary Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics::Galaxy Astrophysics
Abstract

Gas can be violently stripped from their galaxy disks in rich clusters, and be dispersed over 100 kpc-scale tails or plumes. Young stars have been observed in these tails, suggesting they are formed in situ. This will contribute to the intracluster light, in addition to tidal stripping of old stars. We want to quantify the efficiency of intracluster star formation. We present CO(1-0) and CO(2-1) observations, made with the IRAM-30 m telescope, towards the ram-pressure stripped tail northeast of NGC 4388 in Virgo. We selected HII regions found all along the tails, together with dust patches, as observing targets. We detect molecular gas in 4 positions along the tail, with masses between 7 × 105 to 2 × 106M⊙. Given the large distance from the NGC 4388 galaxy, the molecular clouds must have formed in situ, from the HI gas plume. We compute the relation between surface densities of star formation and molecular gas in these regions, and find that the star formation has very low efficiency. The corresponding depletion time of the molecular gas can be up to 500 Gyr and more. Since this value exceeds a by far Hubble time, this gas will not be converted into stars, and will stay in a gaseous phase to join the intracluster medium. © ESO, 2015.

Published
2015

20. Exploration de l’hypotension de liquide cérébro-spinal à l’étage rachidien en IRM

Author

A. Gaston, Anne Maraval, P. Brugieres, C. Combes, Raphaël Blanc, and P. Thomas

Subjects
Epidural venous plexus, Radiological and Ultrasound Technology, business.industry, Medicine, Radiology, Nuclear Medicine and imaging, Neurology (clinical), Nuclear medicine, business
Abstract

Resume Nous proposons une methode simple pour mettre en evidence des signes d’hypotension du liquide cerebrospinal a l’etage cervicothoracique haut. La phlebographie cervicale par resonance magnetique et l’association des techniques de presaturation sus- et sous-jacente au plan de coupe a l’exploration axiale en echo de gradient T1 permettent d’affirmer la nature veineuse des epaississements epiduraux. Ces techniques sont interessantes pour le diagnostic differentiel avec une epidurite neoplasique ou infectieuse.

Published
2006

21. Retard diagnostique dans les hémorragies méningées

Author

A. Redondo, J.-L. Berthelot, and C. Combes

Subjects
Emergency Medicine, Critical Care and Intensive Care Medicine
Abstract

Resume Le diagnostic precoce d’hemorragie meningee permet d’en ameliorer une mortalite et une morbidite importantes. L’objectif de cet article est de determiner les causes des retards diagnostiques. Nous avons repris tous les dossiers des hemorragies meningees hospitalisees dans le service de Neurochirurgie entre 2002 et 2003 en selectionnant les cas de retard diagnostique et nous avons trouve un taux de 16 %, qui est conforme aux donnees de la litterature. Dans tous les cas il s’agissait d’hemorragies meningees pauci-symptomatiques dont diagnostic doit etre systematiquement envisage devant une cephalee brutale ou d’intensite inhabituelle qui est le seul signe constant d’hemorragie meningee. Il faut insister sur l’absence de raideur meningee dans deux tiers des cas car elle est a l’origine de la plupart des erreurs diagnostiques. La cephalee en coup de tonnerre (« thunder clap headhache ») qui peut avoir exactement la meme semiologie est le principal diagnostic differentiel. Mais ce diagnostic ne peut etre retenu qu’apres scanner cerebral en urgence et ponction lombaire normaux.

Published
2005

22. CSF Flow Imaging of the Spine

Author

P Brugieres, C Combes, L. Ruel, P. Thomas, and A. Gaston

Subjects
Radiological and Ultrasound Technology, business.industry, Csf flow, Flow imaging, 030218 nuclear medicine & medical imaging, Spine (zoology), 03 medical and health sciences, 0302 clinical medicine, Medicine, Radiology, Nuclear Medicine and imaging, Neurology (clinical), business, Nuclear medicine, 030217 neurology & neurosurgery
Published
2004

23. Pediatric cerebral venous thrombosis: Description and prognosis according to the physiopathological mechanism in a population of 40 cases

Author

Pierre Meyer, Agathe Roubertie, C. Combes, D. Cuntz, Julie Leydet, François Rivier, S. Durand, Ulrike Walther-Louvier, O. Plan, Maryline Carneiro, Nicolas Leboucq, C. Langlois, and Gilles Cambonie

Subjects
education.field_of_study, medicine.medical_specialty, Mechanism (biology), business.industry, Population, General Medicine, medicine.disease, Venous thrombosis, Pediatrics, Perinatology and Child Health, medicine, Neurology (clinical), business, education, Intensive care medicine
Published
2017

24. L’insufflation trachéale de gaz permet d’éviter l’hypercapnie chez le traumatisé crânien grave avec syndrome de détresse respiratoire aiguë

Author

J. M. Yeguiayan, Marc Freysz, J.-C. Combes, and A. Chomel

Subjects
ARDS, Respiratory distress, business.industry, General Medicine, respiratory system, Lung injury, medicine.disease, respiratory tract diseases, Head trauma, Anesthesiology and Pain Medicine, Permissive hypercapnia, Intensive care, Anesthesia, medicine, medicine.symptom, business, Hypercapnia, Tidal volume, circulatory and respiratory physiology
Abstract

Purpose The purpose of the ventilatory management of acute respiratory distress syndrome (ARDS) is to avoid any barotrauma to the lungs by decreasing the tidal volume at the expense of permissive hypercapnia. This hypercapnia is extremely dangerous for severe head trauma patients because it increases intracranial pressure. The solution could be the use of tracheal gas which insufflation (TGI) allows the reduction of arterial carbon dioxide tension (PaCO2) while controlling airway pressures.

Published
2001

25. Aqueduct stenosis due to venous ectasia with a dural arteriovenous fistula

Author

A. Gaston, P. Brugieres, C. Meyrignac, P. Heine, P. Decq, C. Combes, and C. El-Khoury

Subjects
Male, Cerebral veins, medicine.medical_specialty, Fistula, Dura mater, Arteriovenous fistula, Constriction, Pathologic, Ectasia, otorhinolaryngologic diseases, medicine, Humans, Radiology, Nuclear Medicine and imaging, Vein, Aged, business.industry, Cerebral Aqueduct, medicine.disease, Cerebral Veins, Magnetic Resonance Imaging, Surgery, Stenosis, medicine.anatomical_structure, Posterior cranial fossa, Arteriovenous Fistula, Dura Mater, sense organs, Neurology (clinical), Radiology, Cardiology and Cardiovascular Medicine, business, Dilatation, Pathologic
Abstract

We report aqueduct compression by venous ectasia in a 65-year-old man with a dural arteriovenous fistula in the posterior cranial fossa draining into a superior vermian vein. Conventional and phase-contrast MRI showed the aqueduct stenosis and the causative dilated vein.

Published
2000

26. Do parasites live in extreme environments? Constructing hostile niches and living in them

Author

C. Combes and Serge Morand

Subjects
Ecological niche, Genetics, Life Cycle Stages, biology, Niche, Environment, Major histocompatibility complex, Acquired immune system, Adaptation, Physiological, Host-Parasite Interactions, Cold Temperature, Infectious Diseases, Antibody Repertoire, biology.protein, Animals, Extreme environment, Parasites, Animal Science and Zoology, Parasitology, Seasons, Adaptation, Local adaptation
Abstract

SUMMARYWe develop the hypothesis that parasites do not invade extreme environments, i.e. hostile hosts, but rather ‘create’ them. We argue that parasites may have driven the evolution of the constitutive and adaptive immune system. This leads to several implications. First, parasites respond to ‘genes to kill’ by ‘genes to survive’ and this triggers an indefinite selection of measures and counter-measures. Second, these revolutionary arms races may lead to local adaptation, in which parasite populations perform better on local hosts. Third, the evolution of the immune system, whose responses are predictable, may allow parasites to specialize, to evade and even to manipulate. Finally we show that the correlations between the increase in the antibody repertoire, the expansion of MHC loci and parasite pressures support our hypothesis that both host complexity and parasite pressures can be invoked to explain the diversity of antibodies, T-receptors and MHC molecules.

Published
1999

27. Hématome rétropharyngé asphyxiant après tentative de pose d’une voie veineuse jugulaire interne

Author

M. Freysz, C. Duvillard, J.-C. Combes, and Y. Coignet

Subjects
medicine.medical_specialty, Anesthesiology and Pain Medicine, business.industry, Anesthesia, medicine, General Medicine, Airway obstruction, medicine.disease, Complication, business, Airway, Surgery
Abstract

Retropharyngeal haematomas are a rare complication of central venous catheters insertion. A case of a retropharyngeal haematoma in a patient treated by acetylsalicylic acid is reported. This case emphasized the difficulty in diagnosis. Close airway surveillance must be done and can lead to surgery in case of airway obstruction.

Published
2008

28. What makes a fish a suitable host for Monogenea in the Mediterranean?

Author

A. Caro, L. Euzet, and C. Combes

Subjects
Mediterranean climate, Ecology, Fauna, Fish species, Marine fish, General Medicine, Biology, biology.organism_classification, Phylogenetics, Parasite hosting, Animal Science and Zoology, Parasitology, Species richness, Monogenea
Abstract

Monogenean richness of marine fish is highly variable among host families and species. On the basis of 160 fish species selected because their parasite fauna was considered as ‘adequately’ investigated, an attempt was made to find associations between parasite richness and various characters of the hosts. No clear correlation was found with maximal size, although the smallest species (less than 10cm) seem to never harbour monogeneans. Correlations were found with nectonic, migrating and gregarious behaviours. However, taxonomy of fish appears to be extremely important as a determinant of monogenean richness. In the absence of a satisfactory phylogeny of hosts, no attempt was made to control the analysis for phylogeny. However, removing some families characterized by a high parasite richness (sparids, sciaenids, mugilids) shows that the association with gregariousness holds, whereas the others tend to disappear.

Published
1997

29. Utilisation d'une échelle d'hétéroévaluation de la douleur chez le sujet sévérement polyhandicapé

Author

J. C. Combes, Bernard Giusiano, P. Collignon, and A. M. Boutin

Subjects
Gynecology, medicine.medical_specialty, Mental deficiency, Anesthesiology and Pain Medicine, business.industry, Validation test, medicine, Physical handicap, business
Abstract

L'evaluation de la douleur chez le sujet severement polyhandicape est particulierement difficile du fait de la restriction extreme de l'autonomie, des possibilites de perception, d'expression et de relation qui definissent cette pathologie. Nous avons elabore et valide une echelle d'heteroevaluation comportant 10 ITEMS adaptee a ce type de patient. Nous rapportons nos premieres experiences d'utilisation de cette grille sur 25 dossiers tires au sort. Pour apprecier l'impact potentiel de l'utilisation de l'echelle, nous mettons en parallele chaque situation clinique et la decision proposee par l'echelle. L'echelle d'evaluation permet une meilleure sensibilite dans l'approche diagnostique de la douleur puisqu'elle propose une decision binaire avec la necessite de reconsiderer le traitement antalgique dans des situations ou le clinicien ne prend pas spontanement cette option.

Published
1997

30. Embolization of renal arteries before transplantation in patients with polycystic kidney disease: a single institution long-term experience

Author

Nicolas Grenier, F. Petitpierre, Pierre Merville, Y. Le Bras, C. Combes, Lionel Couzi, A. S. Lasserre, Jean-Marie Ferriere, and François Cornelis

Subjects
medicine.medical_specialty, business.industry, medicine.medical_treatment, medicine.disease, Transplantation, Polycystic kidney disease, Medicine, Radiology, Nuclear Medicine and imaging, In patient, Radiology, Embolization, Single institution, Cardiology and Cardiovascular Medicine, business
Published
2016

31. Neonatal mortality and morbidity in preterm infants born from assisted reproductive technologies

Author

J C, Picaud, S, Chalies, C, Combes, G, Mercier, H, Dechaud, and G, Cambonie

Subjects
Male, Reproductive Techniques, Assisted, Infant, Newborn, Gestational Age, Infant, Premature, Diseases, Severity of Illness Index, Survival Rate, Logistic Models, Pregnancy, Infant Mortality, Multivariate Analysis, Humans, Premature Birth, Female, France, Prospective Studies, Infant, Premature
Abstract

Premature birth is frequent in infants conceived with assisted reproductive technologies (ART). We sought to determine whether neonatal outcome in ART preterm infants differs from that of spontaneously conceived (SC) preterm infants.Data were prospectively collected in infants born ≤ 32 weeks after ART or SC. We calculated a composite index of severe morbidity (based on occurrences of severe necrotizing enterocolitis, severe intraventricular haemorrhage, periventricular leukomalacia or bronchopulmonary dysplasia). Survival rate without severe morbidity was compared between the two groups.Six hundred and twelve preterm infants were hospitalized in our tertiary care centre: 81 in ART group and 521 in SC group. In the ART group, twin pregnancy (69.1% vs. 15.9%, p0.001) and inborn delivery (98.8% vs. 90.0%, p0.01) were more frequent. Gestational age (29 vs. 28 weeks, p0.05) and birth weight (1100 vs. 1020 g, p0.001) were also higher. Survival without severe morbidity was significantly higher in ART infants (76.5% vs. 55.2%, p0.001), with the difference mainly observed in infants born ≤ 28 weeks (22.9% vs. 55.7%, p0.001).Assisted reproductive technologies was not associated with adverse neonatal outcome. Differences in pregnancy and neonatal characteristics probably explain the increased survival without severe morbidity in ART infants.

Published
2012

40. Mycosis fungoides

Author

F C, COMBES

Subjects
Mycosis Fungoides, Humans
Published
2010

41. Granuloma inguinale

Author

F C, COMBES

Subjects
Granuloma Inguinale, Granuloma, Humans
Published
2010

42. EFFECT OF DIFFERENT MOLLUSC ASSOCIATIONS ON TARGET MOLLUSC GROWTH AND PARASITE CERCARIAL PRODUCTION IN THE TRIPLE SYSTEM: BULINUS WRIGHTI-SCHISTOSOMA BOVIS AND MELANOPSIS PRAEMORSA

Author

M. Jana, A. Mouahid, H. Mone, C. Combes, and N. Bouhaddioui

Subjects
biology, Ecology, Bulinus wrighti, Zoology, Aquatic Science, biology.organism_classification, Melanopsis praemorsa, Schistosoma bovis, Gastropoda, Parasite hosting, Animal Science and Zoology, Trematoda, Mollusca, Non target organism
Published
1992

43. [Drug compliance and health locus of control in schizophrenia]

Author

C, Combes and F, Feral

Subjects
Adult, Male, Psychiatric Status Rating Scales, Depressive Disorder, Hallucinations, Awareness, Middle Aged, Delusions, Medication Adherence, Patient Education as Topic, Surveys and Questionnaires, Schizophrenia, Humans, Female, Schizophrenic Psychology, Attitude to Health, Internal-External Control, Antipsychotic Agents
Abstract

Schizophrenia is a frequent disorder since it affects about 1% of the general population. Drug compliance, that is to say patients' adherence to their treatment, remains rather poor concerning this disease with, on an average, one patient out of two not complying with his/her medication. Among the factors influencing drug compliance, we focused on patients' beliefs in terms of health control, a concept known as health locus of control. This is a concept that originated from social psychology and derived from the Rotters' original concept of locus of control: it corresponds to the type of connexion established by an individual between subsequent events in the history of his/her disease and internal (personal abilities) or external factors (chance, powerful others). Nowadays, the tridimensional structure of this concept is commonly admitted as being in three dimensions: internality, chance externality and powerful others externality, the latter group being divided between doctors and others. We have assumed that there is a correlation between the degree of drug compliance and the internal and/or doctors' external health locus of control. For this purpose, we have determined the quality of drug compliance by using the Medical Adherence Rating Scale (MARS) and the type of health locus of control by using the Multidimensional Health Locus of Control (MHLC) scale among 65 schizophrenic patients. We have also considered it was important to evaluate patients' insight by using the Amador's scale (Scale of Unawareness of Mental Disorder) because many researchers have established a strong correlation between insight and drug compliance in schizophrenia. Associations between the four dimensions of health locus of control ("internal", "chance external", "others external" and "doctors' external") and drug compliance were assessed by estimating Spearman's rank correlation coefficient (r) and its degree of significance (p). These associations were judged significant at an alpha threshold of 5%, which corresponded to a level of p inferior to 0.05. Our results tend to confirm a statistically significant positive correlation between internal (r=0.25; p=0.043) and/or doctors' external (r=0.27; p=0.027) health locus of control and drug compliance. Conversely, there is no correlation between chance external or others' external health locus of control and drug compliance (p0.05). This means that the more patients believe that their schizophrenia can be controlled by themselves and/or by doctors, the more they follow their prescriptions. Furthermore, the link between health locus of control and drug compliance appears to be confused by two dimensions of insight, namely awareness of the response to the treatment and perceived need for treatment. An application of these results is that, in the case of patients whose health locus of control is chance or others' external, it can be beneficial to attempt to change their beliefs in order to improve drug compliance. These results hold particular interest in the field of psycho-education and can be directly applied to cognitive therapy for beliefs among stabilized schizophrenic patients.

Published
2009

44. [Lymphoma of the pituitary stalk]

Author

S, Krypciak, E, Alonso, M, Berle, C, Ajzenberg, C, Combes, P, Caillet, E, Taillandier-Heriche, and E, Paillaud

Subjects
Central Nervous System Neoplasms, Antimetabolites, Antineoplastic, Methotrexate, Lymphoma, Biopsy, Humans, Female, Pituitary Neoplasms, Tomography, X-Ray Computed, Magnetic Resonance Imaging, Spinal Puncture, Survival Analysis, Aged
Abstract

Tumors of the pituitary stalk are rare and their diagnosis is sometimes difficult.We report a case of a primary lymphoma of the pituitary stalk in a 78-year-old patient. To our knowledge, only seven similar cases have been previously published: prominent symptoms were headache, fatigue and diplopia; biologically, anterior pituitary low secretion or hyperprolactinemia were found in the majority of cases; regarding the imaging, only three patients presented an initial and isolated lesion of the stalk; histological evidence was obtained by a trans-sphenoidal biopsy in case of hypothalamic or pituitary associated lesion or by a trans-cranial biopsy in the event of an isolated lesion. As an alternative, a lumbar puncture could be performed; although less invasive, its diagnostic performance is lower.Current treatment relies on chemotherapy with intravenous methotrexate associated with intrathecal methotrexate infusion if cerebrospinal showed abnormal cells. Unfortunately, the results remain poor with a median survival of 9 months.

Published
2009

46. D’où viennent les parasites de l’homme?

Author

C. Combes

Subjects
Evolutionary biology, Homo sapiens, Parasitism, Parasitology, Biological evolution, Biology, Host specificity
Abstract

Etude historique de l'evolution des parasitoses chez l'homme. En particulier sont etudies le role joue par les comportements humains, les mecanismes des changements de specificite, l'identite des phylums d'hotes originels, les consequences dynamiques et genetiques pour les parasites et les relations avec l'histoire evolutive des ancetres de l'homosapiens sapiens

Published
1990

47. [Upper airway obstruction by retropharyngeal haematoma: a complication of central venous catheter insertion attempt]

Author

Y, Coignet, J-C, Combes, C, Duvillard, and M, Freysz

Subjects
Airway Obstruction, Catheterization, Central Venous, Hematoma, Humans, Female, Pharyngeal Diseases, Aged
Abstract

Retropharyngeal haematomas are a rare complication of central venous catheters insertion. A case of a retropharyngeal haematoma in a patient treated by acetylsalicylic acid is reported. This case emphasized the difficulty in diagnosis. Close airway surveillance must be done and can lead to surgery in case of airway obstruction.

Published
2007

48. [Chikungunya in paediatrics: epidemic of 2005-2006 in Saint-Denis, Reunion Island]

Author

S, Ernould, H, Walters, J-L, Alessandri, B, Llanas, M-C, Jaffar, S, Robin, T, Attali, D, Ramful, and J-C, Combes

Subjects
Hospitalization, Adolescent, Alphavirus Infections, Child, Preschool, Infant, Newborn, Humans, Infant, Child, Chikungunya virus, Reunion, Demography, Retrospective Studies
Abstract

During the southern-hemispheric 2005-2006 summer, Reunion Island was struck by an epidemic of Chikungunya (Chik), which affected more than a third of the overall population.Our objective was to describe pediatric cases of Chick.We conducted a retrospective descriptive monocentric study of confirmed pediatric cases of Chik recruited at Saint-Denis' departmental hospital during the peak of the epidemic (January 1st to April 30th 2006).Eighty-six children aged 10 days to 18 years were included. In addition to the typical clinical presentation, we observed other phenotypes. Well-known complicated forms with neurologic, cardiac, gastro-intestinal (plus dehydration) involvement were thoroughly investigated using modern medical technology. We observed 2 fatal cases of acute disease in 9-year-old children: death resulted from a central nervous system insult in one case, and multisystemic neurological, cardiac, haemorrhagic involvement in another. Severe acute presentations requiring hospital admission involved mainly children aged less than 6 months, and those with cardiac, skin and neurologic impairment. The study identified 3 cases of epidermolysis bullosa, which to our knowledge, have never been described previously.Chik in children warrants further research in order to propose early and appropriate treatments to avoid complications.

Published
2007

49. [MRI evaluation of cervicothoracic CSF hypotension]

Author

A, Maraval, P, Brugieres, C, Combes, P, Thomas, R, Blanc, and A, Gaston

Subjects
Adult, Diagnosis, Differential, Male, Cerebrospinal Fluid Pressure, Intracranial Hypotension, Contrast Media, Humans, Female, Gadolinium, Middle Aged, Magnetic Resonance Imaging, Magnetic Resonance Angiography
Abstract

We propose studying signs of cervicothoracic CSF hypotension by MRI. Axial T1-weighted GRE sequence with and without saturation bands positioned above and below the selected image plane, MR venography and MR Angiography with contrast administration are helpful to confirm the venous nature of the epidural thickening and to make the differential diagnosis with infectious or neoplastic epiduritis.

Published
2006

50. Reliability of computed tomographic angiography in the diagnosis of brain death

Author

J.-C. Combes, A. Chomel, F. Ricolfi, M. Freysz, and P. d’Athis

Subjects
Adult, Male, medicine.medical_specialty, Brain Death, Posterior cerebral artery, medicine.artery, Cause of Death, medicine, Anterior cerebral artery, Humans, Prospective Studies, Cerebral perfusion pressure, Aged, Transplantation, medicine.diagnostic_test, business.industry, Patient Selection, Reproducibility of Results, Electroencephalography, Middle Aged, Internal Cerebral Vein, Cerebral blood flow, Cerebrovascular Circulation, Middle cerebral artery, Angiography, Surgery, Female, Radiology, France, business, Tomography, X-Ray Computed, Cerebral angiography
Abstract

Objective. This study examined the validity of cerebral computed tomographic (CT) angiography in the diagnosis of brain death (BD) compared with conventional cerebral angiography. Methods. This prospective, monocentric study was performed over a 24-month period and included 43 patients, at least 18 years of age, with clinical criteria of BD. All patients underwent cerebral CT angiography and then cerebral angiography. To confirm BD, the CT scan had to show the absence of perfusion of A2 anterior cerebral artery segments (A2-ACA), M4 middle cerebral artery segments (M4-MCA), P2 posterior cerebral artery segments (P2-PCA), basilar artery, internal cerebral veins, and finally the great cerebral vein. Cerebral angiography showed cerebral blood flow arrest at the level of the foramen magnum for posterior circulation and carotid siphon for anterior circulation. Results. For 30 patients, BD was confirmed by both examinations. For 13 patients, cerebral angiography confirmed BD, whereas CT angiography still showed cerebral perfusion; the divergence rate was 30.2%. Conclusions. CT angiography seems to be a promising exam to confirm BD. However, the divergence with cerebral angiography is significant mainly concerning A2-ACA, which are proximal. It may be possible to only use the absence of opacification of M4-MCA, P2-PCA, basilar artery, and venous blood return to remain in conformity with the French law. In all cases, the international medical community should obtain a consensus for the interpretation of CT angiography to use it extensively as a complementary exam for BD.

Published
2006

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